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Since the Covid-19 Pandemic, growth in the sale/interaction of/with digital games has been recorded. This study analyzed the contributions of digital games that bring information linked to Health in their narratives, in this case, to the epidemiological aspects of a Pandemic. To this end, based on a survey of the literature, referring to the relationship between digital games and digital teaching spaces, the Pandemic game was chosen as the object of study due to its hybrid characteristic (Analogical/Digital), being analyzed through the principles of Heuristic Assessment of Gameplay. After analysis, the potential of this digital artifact for discussing the Biology curriculum was highlighted, in addition to the specific development of a didactic sequence linked to the contents of the area. It was possible to see that games, like Pandemic, are capable of contributing to the development of pedagogical interventions that directly and indirectly deal with health issues involving a health crisis, such as a Pandemic. [ABSTRACT FROM AUTHOR]

Musculoskeletal models and forward dynamics simulations of human movement often include foot–ground interactions, with the foot–ground contact forces often determined using a constitutive model that depends on material properties and contact kinematics. When using soft constraints to model the foot–ground interactions, the kinematics of the minimum distance between the foot and planar ground needs to be computed. Due to their geometric simplicity, a considerable number of studies have used point–plane elements to represent these interacting bodies, but few studies have provided comparisons between point contact elements and other geometrically based analytical solutions. The objective of this work was to develop a more general-purpose superellipsoid–plane contact model that can be used to determine the three-dimensional foot–ground contact forces. As an example application, the model was used in a forward dynamics simulation of human walking. Simulation results and execution times were compared with a point-like viscoelastic contact model. Both models produced realistic ground reaction forces and kinematics with similar computational efficiency. However, solving the equations of motion with the surface contact model was found to be more efficient (~18% faster), and on average numerically ~37% less stiff. The superellipsoid–plane elements are also more versatile than point-like elements in that they allow for volumetric contact during three-dimensional motions (e.g. rotating, rolling, and sliding). In addition, the superellipsoid–plane element is geometrically accurate and easily integrated within multibody simulation code. These advantages make the use of superellipsoid–plane contact models in musculoskeletal simulations an appealing alternative to point-like elements. [ABSTRACT FROM AUTHOR]

The response of bovine bone to the presence of an implant is analysed with the aim of simulating bone remodelling in a developing model of a polymeric intramedullary interlocking nail for veterinary use. A 3-D finite element model of the femur diaphysis is built based on computed tomography images and using a CAD-based modelling pipeline. The bone remodelling process after the surgery is analysed and compared with the healthy bone. The remodelling law assumes that bone adapts to the mechanical environment. For the analyses a consistent set of loads is determined for the bovine walk cycle. The remodelling results reproduce the morphologic features of bone and provide evidence of the difference on the bone behaviour when comparing metallic and polymeric nails. Our findings indicate that an intramedullary polymeric nail has the advantage over the metallic one of improving long-term bone healing and possibly avoiding the need of the implant removal. [ABSTRACT FROM AUTHOR]

Viruses are associated with several human diseases that infect a large number of individuals, hence directly affecting global health and economy. Owing to the lack of efficient vaccines, antiviral therapy and emerging resistance strains, many viruses are considered as a potential threat to public health. Therefore, researches have been developed to identify new drug candidates for future treatments. Among them, antiviral research based on natural molecules is a promising approach. Phospholipases A 2 (PLA 2 s) isolated from snake venom have shown significant antiviral activity against some viruses such as Dengue virus, Human Immunodeficiency virus, Hepatitis C virus and Yellow fever virus, and have emerged as an attractive alternative strategy for the development of novel antiviral therapy. Thus, this review provides an overview of remarkable findings involving PLA 2 s from snake venom that possess antiviral activity, and discusses the mechanisms of action mediated by PLA 2 s against different stages of virus replication cycle. Additionally, molecular docking simulations were performed by interacting between phospholipids from Dengue virus envelope and PLA 2 s from Bothrops asper snake venom. Studies on snake venom PLA 2 s highlight the potential use of these proteins for the development of broad-spectrum antiviral drugs., (Copyright © 2020. Published by Elsevier B.V.)

In this study, a three-dimensional finite element (FE) model based on the specific anatomy of a patient presenting a femoroacetabular impingement of the 'cam'-type is developed. The FE meshes of the structures of interest are obtained from arthrographic magnetic resonance images. All soft tissues are considered linear elastic and isotropic, and the bones were assumed rigid. A compression of the femur on the acetabular cavity as well as flexural movements and internal rotations are applied. Stresses and contact pressures are evaluated in this patient-specific model in order to better interpret the mechanism of aggression of the femoral and acetabular cartilages. The corresponding results are presented and discussed. The values obtained for the contact pressures are similar to those reported by other models based on idealised geometries. An FE analysis of a non-cam hip is also performed for comparison with the pathological case.