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1. Combining Particle Tracking with Electromagnetic Radiation Showers: Merging GPT and Geant4 with Visualization

Author

Dowell, David H., Hindi, Munther, van der Geer, S. B., and de Loos, M. J.

Subjects
Physics - Accelerator Physics
Abstract

Field emitted electrons can seriously affect the operation of high-field, high-duty factor electron accelerators. Accelerated field emission can result in high average power beams which can radiation damage beamline components. In addition, localized losses generate thermal hot spots whose outgassing degrades the ultra-high vacuum required in photoinjectors and cryomodules. However, despite their importance, the effects of field emission are rarely included in the design and engineering of electron injectors. This work attempts to remedy this situation by combining two well-known and well-documented programs, GPT and Geant4, to track electrons and their losses in an injector beamline. This paper describes a system of programs which simulates electron paths and losses along the beamline. In addition, the tracking results can be zoomed and panned along and about the beampipe envelope using an open-source 3D CAD program. The scattering albedo calculations of the combined program, GPT-Geant4, are shown to be in good agreement with the literature albedos. The paper concludes with a dark current simulation for the LCLS-II injector from the cathode to the collimator at 1.5 m from the cathode.

Published
2022

5. Beyond the Limits of 1D Coherent Synchrotron Radiation

Author

Brynes, A. D., Smorenburg, P., Akkermans, I., Allaria, E., Badano, L., Brussaard, S., Danailov, M., Demidovich, A., De Ninno, G., Gauthier, D., Gaio, G., van der Geer, S. B., Giannessi, L., de Loos, M. J., Mirian, N. S., Penco, G., Rebernik, P., Rossi, F., Setija, I., Spampinati, S., Spezzani, C., Trovò, M., Williams, P. H., and DiMitri, S.

Subjects
Physics - Accelerator Physics
Abstract

An understanding of collective effects is of fundamental importance for the design and optimisation of the performance of modern accelerators. In particular, the design of an accelerator with strict requirements on the beam quality, such as a free electron laser (FEL), is highly dependent on a correspondence between simulation, theory and experiments in order to correctly account for the effect of coherent synchrotron radiation (CSR), and other collective effects. A traditional approach in accelerator simulation codes is to utilise an analytic one-dimensional approximation to the CSR force. We present an extension of the 1D CSR theory in order to correctly account for the CSR force at the entrance and exit of a bending magnet. A limited range of applicability to this solution, in particular in bunches with a large transverse spot size or offset from the nominal axis, is recognised. More recently developed codes calculate the CSR effect in dispersive regions directly from the Lienard-Wiechert potentials, albeit with approximations to improve the computational time. A new module of the General Particle Tracer (GPT) code was developed for simulating the effects of CSR, and benchmarked against other codes. We experimentally demonstrate departure from the commonly used 1D CSR theory for more extreme bunch length compression scenarios at the FERMI FEL facility. Better agreement is found between experimental data and the codes which account for the transverse extent of the bunch, particularly in more extreme compression scenarios., Comment: 33 pages, 19 figures, submitted to New J. Phys

Published
2018
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6. Buikwandbreuken

Author

de Vries Reilingh, T. S., van den Heuvel, B., Loos, M. J. A., Heineman, E., editor, Heineman, D.J., editor, Lange jr., J.F.M., editor, Blankensteijn, J.D., editor, Boermeester, M.A., editor, Borel Rinkes, I.H.M., editor, Klaase, J.M., editor, Schipper, I.B., editor, Schreurs, W.H., editor, and Wijnen, R.M.H., editor

Published
2021
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14. Compression of sub-relativistic space-charge-dominated electron bunches for single-shot femtosecond electron diffraction

Author

van Oudheusden, T., Pasmans, P. L. E. M., van der Geer, S. B., de Loos, M. J., van der Wiel, M. J., and Luiten, O. J.

Subjects
Physics - Accelerator Physics
Abstract

We demonstrate compression of 95 keV, space-charge-dominated electron bunches to sub-100 fs durations. These bunches have sufficient charge (200 fC) and are of sufficient quality to capture a diffraction pattern with a single shot, which we demonstrate by a diffraction experiment on a polycrystalline gold foil. Compression is realized by means of velocity bunching as a result of a velocity chirp, induced by the oscillatory longitudinal electric field of a 3 GHz radio-frequency cavity. The arrival time jitter is measured to be 80 fs.

Published
2010
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18. PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer

Author

Su, Y, Loos, M, Giese, N, Hines, OJ, Diebold, I, Görlach, A, Metzen, E, Pastorekova, S, Friess, H, and Büchler, P

Subjects
Digestive Diseases, Cancer, Aetiology, 2.1 Biological and endogenous factors, Adenocarcinoma, Animals, Annexin A5, Apoptosis, Carcinoma, Pancreatic Ductal, Caspase 3, Cell Differentiation, Cell Line, Tumor, Dioxygenases, Enzyme-Linked Immunosorbent Assay, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Hypoxia-Inducible Factor-Proline Dioxygenases, Mice, Neoplasm Invasiveness, Neovascularization, Pathologic, Pancreatic Neoplasms, Polymerase Chain Reaction, RNA, Messenger, RNA, Neoplasm, Reverse Transcriptase Polymerase Chain Reaction, Transplantation, Heterologous, Up-Regulation, Vascular Endothelial Growth Factor A, angiogenesis, HIF-1, hypoxia, pancreatic cancer, PHD3, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

PurposeTumour hypoxia activates hypoxia-inducible factor-1 (HIF-1) and indluences angiogenesis, cell survival and invasion. Prolyl hydroxylase-3 (PHD3) regulates degradation of HIF-1α. The effects of PHD3 in tumour growth are largely unknown.Experimental designPHD3 expression was analysed in human pancreatic cancer tissues and cancer cell lines by real-time quantitative PCR and immunohistochemistry. PHD3 overexpression was established by stable transfection and downregulation by short interfering RNA technology. VEGF was quantified by enzyme-linked immunosorbent assay. Matrigel invasion assays were performed to examine tumour cell invasion. Apoptosis was measured by annexin-V staining and caspase-3 assays. The effect of PHD3 on tumour growth in vivo was evaluated in an established orthotopic murine model.ResultsPHD3 was upregulated in well-differentiated human tumours and cell lines, and regulated hypoxic VEGF secretion. PHD3 overexpression mediated tumour cell growth and invasion by induction of apoptosis in a nerve growth factor-dependent manner by the activation of caspase-3 and phosphorylation of focal adhesion kinase HIF-1 independently. In vivo, PHD3 inhibited tumour growth by abrogation of tumour angiogenesis.ConclusionOur results indicate essential functions of PHD3 in tumour growth, apoptosis and angiogenesis and through HIF-1-dependent and HIF-1-independent pathways.

Published
2010

19. Development of biotissue training models for anastomotic suturing in pancreatic surgery

Author

Karadza, E., primary, Haney, C.M., additional, Limen, E.F., additional, Müller, P.C., additional, Kowalewski, K.F., additional, Sandini, M., additional, Wennberg, E., additional, Schmidt, M.W., additional, Felinska, E.A., additional, Lang, F., additional, Salg, G., additional, Kenngott, H.G., additional, Rangelova, E., additional, Mieog, S., additional, Vissers, F., additional, Korrel, M., additional, Zwart, M., additional, Sauvanet, A., additional, Loos, M., additional, Mehrabi, A., additional, de Santibanes, M., additional, Shrikhande, S.V., additional, Abu Hilal, M., additional, Besselink, M.G., additional, Müller-Stich, B.P., additional, Hackert, T., additional, and Nickel, F., additional

Published
2023
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22. Association of Hospital Volume with Perioperative Mortality of Endovascular Repair of Complex Aortic Aneurysms: A Nationwide Cohort Study

Author

Alberga, Anna J., von Meijenfeldt, Gerdine C. I., Rastogi, Vinamr, de Bruin, Jorg L., Wever, Jan J., van Herwaarden, Joost A., Hamming, Jaap F., Hazenberg, Constantijn E. V. B., van Schaik, Jan, Mees, Barend M. E., van der Laan, Maarten J., Zeebregts, Clark J., Schurink, Geert W. H., Verhagen, Hence J. M., van den Akker, P. J., Akkersdijk, G. P., Akkersdijk, W. L., van Andringa de Kempenaer, M. G., Arts, C. H. P., Avontuur, A. M., Bakker, O. J., Balm, R., Barendregt, W. B., Bekken, J. A., Bender, M. H. M., Bendermacher, B. L. W., van den Berg, M., Beuk, R. J., Blankensteijn, J. D., Bode, A. S., Bodegom, M. E., van der Bogt, K. E. A., Boll, A. P. M., Booster, M. H., Borger van der Burg, B. L. S., de Borst, G. J., Bos-van Rossum, W. T. G. J., Bosma, J., Botman, J. M. J., Bouwman, L. H., Brehm, V., de Bruijn, M. T., de Bruin, J. L., Brummel, P., van Brussel, J. P., Buijk, S. E., Buimer, M. G., Buscher, H. C. J. L., Cancrinus, E., Castenmiller, P. H., Cazander, G., Cuypers, P. W. M., Daemen, J. H. C., Dawson, I., Dierikx, J. E., Dijkstra, M. L., Diks, J., Dinkelman, M. K., Dirven, M., Dolmans, D. E. J. G. J., van Dortmont, L. M. C., Drouven, J. W., van der Eb, M. M., Eefting, D., van Eijck, G. J. W. M., Elshof, J. W. M., Elsman, A. H. P., van der Elst, A., van Engeland, M. I. A., van Eps, G. S., Faber, M. J., de Fijter, W. M., Fioole, B., Fritschy, W. M., Fung Kon Jin, P. H. P., Geelkerken, R. H., van Gent, W. B., Glade, G. J., Govaert, B., Groenendijk, R. P. R., de Groot, H. G. W., van den Haak, R. F. F., de Haan, E. F. A., Hajer, G. F., Hamming, J. F., van Hattum, E. S., Hazenberg, C. E. V. B., Hedeman Joosten, P. P. A., Helleman, J. N., van der Hem, L. G., Hendriks, J. M., van Herwaarden, J. A., Heyligers, J. M. M., Hinnen, J. W., Hissink, R. J., Ho, G. H., den Hoed, P. T., Hoedt, M. T. C., van Hoek, F., Hoencamp, R., Hoffmann, W. H., Hoksbergen, A. W. J., Hollander, E. J. F., Huisman, L. C., Hulsebos, R. G., Huntjens, K. M. B., Idu, M. M., Jacobs, M. J. H. M., van der Jagt, M. F. P., Jansbeken, J. R. H., Janssen, R. J. L., Jiang, H. H. L., de Jong, S. C., Jongbloed-Winkel, T. A., Jongkind, V., Kapma, M. R., Keller, B. P. J. A., Jahrome, A. Khodadade, Kievit, J. K., Klemm, P. L., Klinkert, P., Koedam, N. A., Koelemaij, M. J. W., Kolkert, J. L. P., Koning, G. G., Koning, O. H. J., Konings, R., Krasznai, A. G., Kropman, R. H. J., Kruse, R. R., van der Laan, L., van der Laan, M. J., van Laanen, J. H. H., van Lammeren, G. W., Lamprou, D. A. A., Lardenoije, J. H. P., Lauret, G. J., Leenders, B. J. M., Legemate, D. A., Leij-Dekkers, V. J., Lemson, M. S., Lensvelt, M. M. A., Lijkwan, M. A., van der Linden, F. T. P. M., Lung, P. F. L., Loos, M. J. A., Loubert, M. C., van de Luijtgaarden, K. M., Mahmoud, D. E. A. K., Manshanden, C. G., Mat-Tens, E. C. J. L., Meerwaldt, R., Mees, B. M. E., Menting, T. P., Metz, R., de Mol van Otterloo, J. C. A., Molegraaf, M. J., Montauban van Swijn-Dregt, Y. C. A., Morak, M. J. M., van de Mortel, R. H. W., Mulder, W., Nagesser, S. K., Naves, C. C. L. M., Nederhoed, J. H., Nevenzel, A. M., de Nie, A. J., Nieuwenhuis, D. H., van Nieuwenhuizen, R. C., Nieuwenhui-Zen, J., Nio, D., Oomen, A. P. A., Oranen, B. I., Oskam, J., Palamba, H. W., Peppelenbosch, A. G., van Petersen, A. S., Petri, B. J., Pierie, M. E. N., Ploeg, A. J., Pol, R. A., Ponfoort, E. D., Poyck, P. P. C., Prent, A., ten Raa, S., Raymakers, J. T. F. J., Reichmann, B. L., Reijnen, M. M. P. J., de Ridder, J. A. M., Rijbroek, A., van Rijn, M. J. E., de Roo, R. A., Rouwet, E. V., Saleem, B. R., van Sambeek, M. R. H. M., Samyn, M. G., van't Sant, H. P., van Schaik, J., van Schaik, P. M., Scharn, D. M., Scheltinga, M. R. M., Schepers, A., Schlejen, P. M., Schlösser, F. J. V., Schol, F. P. G., Scholtes, V. P. W., Schouten, O., Schreve, M. A., Schurink, G. W. H., Sikkink, C. J. J. M., te Slaa, A., Smeets, H. J., Smeets, L., Smeets, R. R., de Smet, A. A. E. A., Smit, P. C., Smits, T. M., Snoeijs, M. G. J., Sondakh, A. O., Speijers, M. J., van der Steenhoven, T. J., van Sterkenburg, S. M. M., Stigter, D. A. A., Stokmans, R. A., Strating, R. P., Stultiëns, G. N. M., Sybrandy, J. E. M., Teijink, J. A. W., Telgenkamp, B. J., Testroote, M. J. G., Tha-in, T., The, R. M., Thijsse, W. J., Thomassen, I., Tielliu, I. F. J., van Tongeren, R. B. M., Toorop, R. J., Tournoij, E., Truijers, M., Türkcan, K., Nolthenius, R. P. Tutein, Ünlü, C., Vaes, R. H. D., Vahl, A. C., Veen, E. J., Veger, H. T. C., Veldman, M. G., Verhagen, H. J. M., Verhoeven, B. A. N., Vermeulen, C. F. W., Vermeulen, E. G. J., Vierhout, B. P., van der Vijver-Coppen, R. J., Visser, M. J. T., van der Vliet, J. A., van Vlijmen-van Keulen, C. J., van der Vorst, J. R., Vos, A. W. F., Vos, C. G., Vos, G. A., de Vos, B., Voûte, M. T., Vriens, B. H. R., Vriens, P. W. H. E., de Vries, D. K., de Vries, J. P. P. M., de Vries, M., de Vries, A. C., van der Waal, C., Waasdorp, E. J., de Vries, B. M. Wallis, van Walraven, L. A., van Wanroi, J. L., Warlé, M. C., van Weel, V., van Well, A. M. E., Welten, G. M. J. M., Wever, J. J., Wiersema, A. M., Wikkeling, O. R. M., Willaert, W. I. M., Wille, J., Willems, M. C. M., Willigendael, E. M., Wilschut, E. D., Wisselink, W., Witte, M. E., Wittens, C. H. A., Wong, C. Y., Yazar, O., Yeung, K. K., Zeebregts, C. J. A. M., van Zeeland, M. L. P., Physiology, ACS - Pulmonary hypertension & thrombosis, Surgery, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, VU University medical center, AII - Inflammatory diseases, APH - Digital Health, Medical Biochemistry, ACS - Diabetes & metabolism, AII - Infectious diseases, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
volume-outcome, complex AAA, endovascular, mortality
Abstract

Objective: We evaluate nationwide perioperative outcomes of complex EVAR and assess the volume-outcome association of complex EVAR. Summary of Background Data: Endovascular treatment with fenestrated (FEVAR) or branched (BEVAR) endografts is progressively used for excluding complex aortic aneurysms (complex AAs). It is unclear if a volumeoutcome association exists in endovascular treatment of complex AAs (complex EVAR). Methods: All patients prospectively registered in the Dutch Surgical Aneurysm Audit who underwent complex EVAR (FEVAR or BEVAR) between January 2016 and January 2020 were included. The effect of annual hospital volume on perioperative mortality was examined using multivariable logistic regression analyses. Patients were stratified into quartiles based on annual hospital volume to determine hospital volume categories. Results: We included 694 patients (539 FEVAR patients, 155 BEVAR patients). Perioperative mortality following FEVAR was 4.5% and 5.2% following BEVAR. Postoperative complication rates were 30.1% and 48.7%, respectively. The first quartile hospitals performed

Published
2023

23. Laser-Free RF-Gun as a Combined Source of Thz and Ps-Sub-Ps X-Rays

Author

Agustsson, R., Boucher, S., Finn, O., Hartzell, J., Ruelas, M., Smirnov, A.V., Storms, S., Ning, Z., Murokh, A., Campese, T., Faillace, L., Verma, A., Kim, Y., Buaphad, P., Andrews, A., Berls, B., Eckman, C., Folkman, K., Knowles-Swingle, A., O’Neill, C., Smith, M., Grandsaert, T., van der Geer, B., de Loos, M., Berg, W.J., Sereno, N.S., Sun, Y., and Zholents, A.A.

Published
2015
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33. Treatment Outcome Trends for Non-Ruptured Abdominal Aortic Aneurysms: A Nationwide Prospective Cohort Study

Author

Alberga, Anna J., Karthaus, Eleonora G., Wilschut, Janneke A., de Bruin, Jorg L., Akkersdijk, George P., Geelkerken, Robert H., Hamming, Jaap F., Wever, Jan J., Verhagen, Hence J. M., van den Akker, P. J., Akkersdijk, G. P., Akkersdijk, W. L., van Andringa de Kempenaer, M. G., Arts, C. H. P., Avontuur, A. M., Bakker, O. J., Balm, R., Barendregt, W. B., Bekken, J. A., Bender, M. H. M., Bendermacher, B. L. W., van den Berg, M., Beuk, R. J., Blankensteijn, J. D., Bode, A. S., Bodegom, M. E., van der Bogt, K. E. A., Boll, A. P. M., Booster, M. H., Borger van der Burg, B. L. S., de Borst, G. J., Bos-van Rossum, W. T. G. J., Bosma, J., Botman, J. M. J., Bouwman, L. H., Brehm, V., de Bruijn, M. T., de Bruin, J. L., Brummel, P., van Brussel, J. P., Buijk, S. E., Buimer, M. G., Buscher, H. C. J. L., Cancrinus, E., Castenmiller, P. H., Cazander, G., Cuypers, P. H. W. M., Daemen, J. H. C., Dawson, I., Dierikx, J. E., Dijkstra, M. L., Diks, J., Dinkelman, M. K., Dirven, M., Dolmans, D. E. J. G. J., van Dortmont, L. M. C., Drouven, J. W., van der Eb, M. M., Eefting, D., van Eijck, G. J. W. M., Elshof, J. W. M., Elsman, B. H. P., van der Elst, A., van Engeland, M. I. A., van Eps, G. S., Faber, M. J., de Fijter, W. M., Fioole, B., Fritschy, W. M., Jin, P. H. P. F. K., Geelkerken, R. H., van Gent, W. B., Glade, G. J., Govaert, B., Groenendijk, R. P. R., de Groot, H. G. W., van den Haak, R. F. F., de Haan, E. F. A., Hajer, G. F., Hamming, J. F., van Hattum, E. S., Hazenberg, C. E. V. B., Hedeman Joosten, P. P. H. A., Helleman, J. N., van der Hem, L. G., Hendriks, J. M., van Herwaarden, J. A., Heyligers, J. M. M., Hinnen, J. W., Hissink, R. J., Ho, G. H., den Hoed, P. T., Hoedt, M. T. C., van Hoek, F., Hoencamp, R., Hoffmann, W. H., Hoksbergen, A. W. J., Hollander, E. J. F., Huisman, L. C., Hulsebos, R. G., Huntjens, K. M. B., Idu, M. M., Jacobs, M. J. H. M., van der Jagt, M. F. P., Jansbeken, J. R. H., Janssen, R. J. L., Jiang, H. H. L., de Jong, S. C., Jongbloed-Winkel, T. A., Jongkind, V., Kapma, M. R., Keller, B. P. J. A., Jahrome, A. K., Kievit, J. K., Klemm, P. L., Klinkert, P., Koedam, N. A., Koelemaij, M. J. W., Kolkert, J. L. P., Koning, G. G., Koning, O. H. J., Konings, R., Krasznai, A. G., Kropman, R. H. J., Kruse, R. R., van der Laan, L., van der Laan, M. J., van Laanen, J. H. H., van Lammeren, G. W., Lamprou, D. A. A., Lardenoije, J. H. P., Lauret, G. J., Leenders, B. J. M., Legemate, D. A., Leijdekkers, V. J., Lemson, M. S., Lensvelt, M. M. A., Lijkwan, M. A., van der Linden, F. T. H. P. M., Lung, P. F. Liqui, Loos, M. J. A., Loubert, M. C., van de Luijtgaarden, K. M., Mahmoud, D. E. A. K., Manshanden, C. G., Mattens, E. C. J. L., Meerwaldt, R., Mees, B. M. E., Menting, T. P., Metz, R., de Mol van Otterloo, J. C. A., Molegraaf, M. J., Montauban van Swijndregt, Y. C. A., Morak, M. J. M., van de Mortel, R. H. W., Mulder, W., Nagesser, S. K., Naves, C. C. L. M., Nederhoed, J. H., Nevenzel, A. M., de Nie, A. J., Nieuwenhuis, D. H., van Nieuwenhuizen, R. C., Nieuwenhuizen, J., Nio, D., Oomen, A. P. A., Oranen, B. I., Oskam, J., Palamba, H. W., Peppelenbosch, A. G., van Petersen, A. S., Petri, B. J., Pierie, M. E. N., Ploeg, A. J., Pol, R. A., Ponfoort, E. D., Poyck, P. P. C., Prent, A., Raa, S. ten, Raymakers, J. T. F. J., Reichmann, B. L., Reijnen, M. M. P. J., de Ridder, J. A. M., Rijbroek, A., van Rijn, M. J. E., de Roo, R. A., Rouwet, E. V., Saleem, B. R., van Sambeek, M. R. H. M., Samyn, M. G., van ’t Sant, H. P., van Schaik, J., van Schaik, P. M., Scharn, D. M., Scheltinga, M. R. M., Schepers, A., Schlejen, P. M., Schlösser, F. J. V., Schol, F. P. G., Scholtes, V. P. W., Schouten, O., Schreve, M. A., Schurink, G. W. H., Sikkink, C. J. J. M., Slaa, A. te, Smeets, H. J., Smeets, L., Smeets, R. R., de Smet, A. A. E. A., Smit, P. C., Smits, T. M., Snoeijs, M. G. J., Sondakh, A. O., Speijers, M. J., van der Steenhoven, T. J., van Sterkenburg, S. M. M., Stigter, D. A. A., Stokmans, R. A., Strating, R. P., Stultiëns, G. N. M., Sybrandy, J. E. M., Teijink, J. A. W., Telgenkamp, B. J., Testroote, M. J. G., Tha-in, T., The, R. M., Thijsse, W. J., Thomassen, I., Tielliu, I. F. J., van Tongeren, R. B. M., Toorop, R. J., Tournoij, E., Truijers, M., Türkcan, K., Tutein Nolthenius, R. P., Ünlü, C., Vaes, R. H. D., Vahl, A. C., Veen, E. J., Veger, H. T. C., Veldman, M. G., Verhagen, H. J. M., Verhoeven, B. A. N., Vermeulen, C. F. W., Vermeulen, E. G. J., Vierhout, B. P., van der Vijver-Coppen, R. J., Visser, M. J. T., van der Vliet, J. A., van Vlijmen - van Keulen, C. J., van der Vorst, J. R., Vos, A. W. F., Vos, C. G., Vos, G. A., de Vos, B., Voûte, M. T., Vriens, B. H. R., Vriens, P. W. H. E., de Vries, D. K., de Vries, J. P. P. M., de Vries, M., de Vries, A. C., van der Waal, C., Waasdorp, E. J., Wallis de Vries, B. M., van Walraven, L. A., van Wanroi, J. L., Warlé, M. C., van Weel, V., van Well, A. M. E., Welten, G. M. J. M., Wever, J. J., Wiersema, A. M., Wikkeling, O. R. M., Willaert, W. I. M., Wille, J., Willems, M. C. M., Willigendael, E. M., Wilschut, E. D., Wisselink, W., Witte, M. E., Wittens, C. H. A., Wong, C. Y., Yazar, O., Yeung, K. K., Zeebregts, C. J. A. M., van Zeeland, M. L. P., ACS - Microcirculation, Anesthesiology, Physiology, ACS - Pulmonary hypertension & thrombosis, Surgery, ACS - Atherosclerosis & ischemic syndromes, VU University medical center, ACS - Diabetes & metabolism, TechMed Centre, Multi-Modality Medical Imaging, Medical Biochemistry, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Male, Time Factors, Operative procedure, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Risk Assessment, Blood Vessel Prosthesis Implantation, Postoperative Complications, Risk Factors, Humans, Hospital Mortality, Prospective Studies, Registries, Treatment outcome, Aged, Netherlands, Retrospective Studies, Aged, 80 and over, Endovascular Procedures, Quality of care, Middle Aged, Endovascular procedure, Abdominal aortic aneurysm, Surgery, Female, Trends, Cardiology and Cardiovascular Medicine, Aortic Aneurysm, Abdominal
Abstract

Contains fulltext : 251573.pdf (Publisher’s version ) (Open Access) OBJECTIVE: The Dutch Surgical Aneurysm Audit (DSAA) initiative was established in 2013 to monitor and improve nationwide outcomes of aortic aneurysm surgery. The objective of this study was to examine whether outcomes of surgery for intact abdominal aortic aneurysms (iAAA) have improved over time. METHODS: Patients who underwent primary repair of an iAAA by standard endovascular (EVAR) or open surgical repair (OSR) between 2014 and 2019 were selected from the DSAA for inclusion. The primary outcome was peri-operative mortality trend per year, stratified by OSR and EVAR. Secondary outcomes were trends per year in major complications, textbook outcome (TbO), and characteristics of treated patients. The trends per year were evaluated and reported in odds ratios per year. RESULTS: In this study, 11 624 patients (74.8%) underwent EVAR and 3 908 patients (25.2%) underwent OSR. For EVAR, after adjustment for confounding factors, there was no improvement in peri-operative mortality (aOR [adjusted odds ratio] 1.06, 95% CI 0.94 - 1.20), while major complications decreased (2014: 10.1%, 2019: 7.0%; aOR 0.91, 95% CI 0.88 - 0.95) and the TbO rate increased (2014: 68.1%, 2019: 80.9%; aOR 1.13, 95% CI 1.10 - 1.16). For OSR, the peri-operative mortality decreased (2014: 6.1%, 2019: 4.6%; aOR 0.89, 95% CI 0.82 - 0.98), as well as major complications (2014: 28.6%, 2019: 23.3%; aOR 0.95, 95% CI 0.91 - 0.99). Furthermore, the proportion of TbO increased (2014: 49.1%, 2019: 58.3%; aOR 1.05, 95% CI 1.01 - 1.10). In both the EVAR and OSR group, the proportion of patients with cardiac comorbidity increased. CONCLUSION: Since the establishment of this nationwide quality improvement initiative (DSAA), all outcomes of iAAA repair following EVAR and OSR have improved, except for peri-operative mortality following EVAR which remained unchanged.

Published
2022

34. Huurverhogingen, algemene voorwaarden en wijzigingsbedingen: Maakt het Hof van Justitie een einde aan oneerlijke huurverhogingen?

Author

Loos, M., Private and Public European Law, and CSECL (FdR)

Abstract

Het Nederlandse huurprijzenrecht voor de huur van woonruimte combineert wettelijke regels over de hoogte van de huurprijs en van de wettelijke huurverhoging voor sociale (en tijdelijk ook voor geliberaliseerde) woonruimte met de mogelijkheid van huurprijsverhoging op basis van een contractueel huurprijswijzigingsbeding bij zowel sociale als geliberaliseerde woonruimte. In dit artikel wordt onderzocht of dit systeem verenigbaar is met de rechtspraak van het Hof van Justitie over prijswijzigingsbedingen in algemene voorwaarden.

Published
2022

36. Inguinal Hernia: Post OP Chronic Pain

Author

Sevonius, D., Montgomery, A., Smedberg, S., Sandblom, G., Zwaans, W., Perquin, C., Roumen, R., Scheltinga, M., Verhagen, T., Loos, M. J. A., Scheltinga, M. R. M., Roumen, R. M. H., Bökkerink, W., Van Laarhoven, C. J. H. M., Koning, G. G., Yang, Z. F., Shen, W. Z., Lu, C., Zheng, W. H., Xiao, W. F., Li, X. R., Narita, M., Matsusue, R., Hata, H., Yamaguchi, T., Otani, T., Ikai, I., Karampinis, I., Weiss, J., Pilz, L., Post, S., Herrle, F., Murphy, J., Yang, F., Meng, L. Q., Meng, X. Z., Chong, Y. Z., Zhao, H. Y., Liu, J. G., van Assen, T., Brouns, J. A. G. M., Scheltinga, M. R., and Roumen, R. M.

Published
2015
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37. Inguinal Hernia: Mesh Fixation

Author

Sun, P., Hu, S. B., Cheng, X., Li, M., Guo, B., Song, Z. F., Zhang, Y., Zheng, Q. C., Hoyuela, C., Vega, L., Carvajal, F., Blay, L., Juvany, M., Camps, J., Veres, A., Besora, P., Trias, M., Feliu, X., Bellanova, G., Viel, G., Fabris, L., Valduga, P., Ciarleglio, F. A., Beltempo, P., Prezzi, C., Berlanda, G., Marcucci, S., Bondioli, P., Brolese, A., Agresta, F., Verza, L. A., Azabdaftari, A., Prando, D., Roveran, M. A., Rubinato, L., Vacca, U., Cesana, G., Ciccarese, F., Uccelli, M., Carrieri, D., Castello, G., Grava, G., Bonfanti, G., Legnani, G., Olmi, S., Chiaretti, M., Martinelli, A., Carru, G. A., Fegatelli, D. Alunni, Chiaretti, A. M., Consentino, P., Chiaretti, A. I., Procacciante, F., Blair, L., Huntington, C., Cox, T., Lincourt, A., Prasad, T., Matthews, B., Augenstein, V., Heniford, B. T., Verhagen, T., Loos, M. J. A., Scheltinga, M. R. M., Roumen, R. M. H., Magalhães, C., Pereira, S., Cardoso, G., Flores, A., Marcos, M., Lionetti, R., Cesaro, A., Napolitano, E., Caruso, L., Neola, B., Rutigliano, M., Ferulano, G. P., Pecic, V., Jovanovic, S., Filipovic, N., Trenkic, M., Pavlovic, A., Jovanovc, B., Tatic, M., Jovanovic, A., Khan, A., Tansawet, A., Lerdsirisopon, S., Techapongsatorn, S., Kasetsermwirija, W., Srimontayamas, S., Loapeamthong, C. U. S., Teawprasert, P., Bellomo, M. P., Bona, A., Borasi, A., Borreca, D., Filippa, C., Manfredi, S., De Paolis, P., Teng, A., Yu, J. W., Hu, Y., Sun, C. L., Zhou, J., Zha, X. G., Li, Y., Wu, J. Z., Abbonante, F., Kosai, N., Yussra, Y., Sutton, P. A., Shabbar, H. F., Razrim, R., Mustaffa, T., Tamil, A., Reynu, R., Abusalih, A., Shen, Y., Chen, J., Yang, S., Wang, M. G., Chen, F. Q., Fenger, A., Helvind, N. M., Pommergaard, H.-C., Burcharth, J., and Rosenberg, J.

Published
2015
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38. Rectum Diastasis, Post Partum Floppy Wall & Obscure Groin Pain in Women

Author

Hu, J., Lomanto, D., Dumanian, G., Cheesborough, J., Ponten, J., Hameeteman, M., Nienhuijs, S., Zahiri, H., Benenati, M., Sibia, U., Sivak, B., Park, A., Belyansky, I., Huang, C. S., Verhagen, T., Loos, M. J. A., Scheltinga, M. R. M., Roumen, R. M. H., Morfesis, F., Rose, B., Zarrinkhoo, E., Towfigh, S., Miller, J., Campanella, A. Messina, Licheri, S., Barbarossa, M., Porceddu, G., Ferraro, G., Virdis, F., Reccia, I., Aresu, S., and Pisanu, A.

Published
2015
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40. Validation of the ISGLS Classification of Bile Leakage after Pancreatic Surgery: A Rare but Severe Complication

Author

Abbasi Dezfouli, S., primary, Mehrabi, A., additional, Schlosser, F., additional, Ramouz, A., additional, Khajeh, E., additional, Al-Saegh, S.A., additional, Loos, M., additional, Strobel, O., additional, Müller-Stich, B., additional, Ünal, U. Kaan, additional, Mieth, M., additional, Klauss, M., additional, Chang, D.-H., additional, Wielpütz, M.O., additional, Büchler, M., additional, and Hackert, T., additional

Published
2022
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41. Consensus on international guidelines for management of groin hernias

Author

van Veenendaal, N., Simons, M., Hope, W., Tumtavitikul, S., Bonjer, J., Aufenacker, T., Berrevoet, F., Bingener, J., Bisgaard, T., Bittner, R., Bury, K., Campanelli, G., Chen, D., Chowbey, P., Conze, J., Cuccurullo, D., De Beaux, A., Eker, H., Fitzgibbons, R., Fortelny, R., Gillion, J. F., Van den Heuvel, B., Jorgensen, L., Klinge, U., Kockerling, F., Kukleta, J., Konate, I., Liem, L., Lomanto, D., Loos, M., Lopez-Cano, M., Miserez, M., Misra, M., Montgomery, A., Morales-Conde, S., Muysoms, F., Niebuhr, H., Nordin, P., Pawlak, M., Van Ramshorst, G., Reinpold, W., Sanders, D., Sani, R., Schouten, N., Smedberg, S., Smietanski, M., Simmermacher, R., Tran, H., Wijsmuller, A., and Surgery

Subjects
Femoral, medicine.medical_specialty, Consensus, Hernia, media_common.quotation_subject, medicine.medical_treatment, Postoperative pain, education, Inguinal hernias, Groin, 03 medical and health sciences, 0302 clinical medicine, Consensus conferences, International guidelines, Hernia, Femoral, Hernia, Inguinal, Herniorrhaphy, Humans, Practice Guidelines as Topic, Voting, Health care, medicine, health care economics and organizations, media_common, business.industry, General surgery, Hernia repair, medicine.disease, surgical procedures, operative, medicine.anatomical_structure, Regional anesthesia, Inguinal, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, business, Abdominal surgery
Abstract

Background: Groin hernia management has a significant worldwide diversity with multiple surgical techniques and variable outcomes. The International guidelines for groin hernia management serve to help in groin hernia management, but the acceptance among general surgeons remains unknown. The aim of our study was to gauge the degree of agreement with the guidelines among health care professionals worldwide. Methods: Forty-six key statements and recommendations of the International guidelines for groin hernia management were selected and presented at plenary consensus conferences at four international congresses in Europe, the America’s and Asia. Participants could cast their votes through live voting. Additionally, a web survey was sent out to all society members allowing online voting after each congress. Consensus was defined as > 70% agreement among all participants. Results: In total 822 surgeons cast their vote on the key statements and recommendations during the four plenary consensus meetings or via the web survey. Consensus was reached on 34 out of 39 (87%) recommendations, and on six out of seven (86%) statements. No consensus was reached on the use of light versus heavy-weight meshes (69%), superior cost-effectiveness of day-case laparo-endoscopic repair (69%), omitting prophylactic antibiotics in hernia repair, general or local versus regional anesthesia in elderly patients (55%) and re-operation in case of immediate postoperative pain (59%). Conclusion: Globally, there is 87% consensus regarding the diagnosis and management of groin hernias. This provides a solid basis for standardizing the care path of patients with groin hernias.

Published
2020

49. Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival

Author

Corradi, C., primary, Gentiluomo, M., additional, Vanella, G., additional, Johansen, A.Z., additional, Loos, M., additional, Szentesi, A., additional, Milanetto, A.C., additional, Hegyi, P., additional, Kupcinskas, J., additional, Tavano, F., additional, Schneider, M., additional, Bozzato, D., additional, Neoptolemos, J.P., additional, Hackert, T., additional, Pezzilli, R., additional, Johansen, J.S., additional, Costello, E., additional, Mohelnikova-Duchonova, B., additional, van Eijck, C.H.J., additional, Talar-Wojnarowska, R., additional, Hansen, C. Palnæs, additional, Darvasi, E., additional, Chen, I.M., additional, Cavestro, G.M., additional, Soucek, P., additional, Piredda, L., additional, Vodicka, P., additional, Gazouli, M., additional, Arcidiacono, P.G., additional, Canzian, F., additional, Campa, D., additional, and Capurso, G., additional

Published
2021
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