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3. Regionalanästhesie und Immunologie.

Author

Semmelmann, A. and Loop, T.

Subjects
INFECTION risk factors, CONTINUING education units, HOMEOSTASIS, IMMUNOLOGY, SYMPATHETIC nervous system, ANALGESIA, GENERAL anesthesia, IMMUNOCOMPETENCE
Abstract

Copyright of Anaesthesiologie & Intensivmedizin is the property of DGAI e.V. - Deutsche Gesellschaft fur Anasthesiologie und Intensivmedizin e.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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7. Correction to: Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial

Author

Kiss, T., Wittenstein, J., Becker, C., Birr, K., Cinnella, G., Cohen, E., El Tahan, M. R., Falcão, L. F., Gregoretti, C., Granell, M., Hachenberg, T., Hollmann, M. W., Jankovic, R., Karzai, W., Krassler, J., Loop, T., Licker, M. J., Marczin, N., Mills, G. H., Murrell, M. T., Neskovic, V., Nisnevitch-Savarese, Z., Pelosi, P., Rossaint, R., Schultz, M. J., Neto, A. Serpa, Severgnini, P., Szegedi, L., Vegh, T., Voyagis, G., Zhong, J., de Abreu, M. Gama, Senturk, M., and for the PROTHOR investigators and the Research Workgroup PROtective VEntilation Network (PROVEnet) of the European Society of Anaesthesiology (ESA)

Published
2019
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8. Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial

Author

Kiss, T., Wittenstein, J., Becker, C., Birr, K., Cinnella, G., Cohen, E., El Tahan, M. R., Falcão, L. F., Gregoretti, C., Granell, M., Hachenberg, T., Hollmann, M. W., Jankovic, R., Karzai, W., Krassler, J., Loop, T., Licker, M. J., Marczin, N., Mills, G. H., Murrell, M. T., Neskovic, V., Nisnevitch-Savarese, Z., Pelosi, P., Rossaint, R., Schultz, M. J., Serpa Neto, A., Severgnini, P., Szegedi, L., Vegh, T., Voyagis, G., Zhong, J., Gama de Abreu, M., Senturk, M., for the PROTHOR investigators, and the Research Workgroup PROtective VEntilation Network (PROVEnet) of the European Society of Anaesthesiology (ESA)

Published
2019
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9. S1-Leitlinie Atemwegsmanagement 2023.

Author

Piepho, T., Kriege, M., Byhahn, C., Cavus, E., Dörges, V., Ilper, H., Kehl, F., Loop, T., Raymondos, K., Sujatta, S., Timmermann, A., Zwißler, B., and Noppens, R.

Subjects
MEDICAL masks, INTENSIVE care units, ANESTHESIOLOGY, AIRWAY (Anatomy), CRITICALLY ill, PATIENTS, MEDICAL protocols, RESPIRATORY therapy, DECISION making in clinical medicine, RESUSCITATION, LARYNGOSCOPY, TRACHEA intubation, CAPNOGRAPHY
Abstract

Copyright of Anaesthesiologie & Intensivmedizin is the property of DGAI e.V. - Deutsche Gesellschaft fur Anasthesiologie und Intensivmedizin e.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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22. Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial

Author

Kiss T., Wittenstein J., Becker C., Birr K., Cinnella G., Cohen E., El Tahan M. R., Falcao L. F., Gregoretti C., Granell M., Hachenberg T., Hollmann M. W., Jankovic R., Karzai W., Krassler J., Loop T., Licker M. J., Marczin N., Mills G. H., Murrell M. T., Neskovic V., Nisnevitch-Savarese Z., Pelosi P., Rossaint R., Schultz M. J., Serpa Neto A., Severgnini P., Szegedi L., Vegh T., Voyagis G., Zhong J., Gama De Abreu M., Senturk M., Anesthesiology, ACS - Heart failure & arrhythmias, Intensive Care Medicine, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, Kiss T., Wittenstein J., Becker C., Birr K., Cinnella G., Cohen E., El Tahan M.R., Falcao L.F., Gregoretti C., Granell M., Hachenberg T., Hollmann M.W., Jankovic R., Karzai W., Krassler J., Loop T., Licker M.J., Marczin N., Mills G.H., Murrell M.T., Neskovic V., Nisnevitch-Savarese Z., Pelosi P., Rossaint R., Schultz M.J., Serpa Neto A., Severgnini P., Szegedi L., Vegh T., Voyagis G., Zhong J., Gama De Abreu M., and Senturk M.

Subjects
one-lung ventilation, Intraoperative Complication, Medicine (miscellaneous), Thoracic Surgical Procedure, recruitment maneuver, Orvostudományok, respiratory system, Thoracic Surgical Procedures, Klinikai orvostudományok, thoracic surgery, respiratory tract diseases, Positive-Pressure Respiration, Mechanical ventilation, positive end-expiratory pressure, postoperative pulmonary complication, Humans, Intraoperative Complications, One-Lung Ventilation, Research Design, Sample Size, Randomized Controlled Trials as Topic, Pharmacology (medical), Human
Abstract

Background: Postoperative pulmonary complications (PPC) may result in longer duration of in-hospital stay and even mortality. Both thoracic surgery and intraoperative mechanical ventilation settings add considerably to the risk of PPC. It is unclear if one-lung ventilation (OLV) for thoracic surgery with a strategy of intraoperative high positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) reduces PPC, compared to low PEEP without RM. Methods: PROTHOR is an international, multicenter, randomized, controlled, assessor-blinded, two-arm trial initiated by investigators of the PROtective VEntilation NETwork. In total, 2378 patients will be randomly assigned to one of two different intraoperative mechanical ventilation strategies. Investigators screen patients aged 18 years or older, scheduled for open thoracic or video-assisted thoracoscopic surgery under general anesthesia requiring OLV, with a maximal body mass index of 35 kg/m 2 , and a planned duration of surgery of more than 60 min. Further, the expected duration of OLV shall be longer than two-lung ventilation, and lung separation is planned with a double lumen tube. Patients will be randomly assigned to PEEP of 10 cmH 2 O with lung RM, or PEEP of 5 cmH 2 O without RM. During two-lung ventilation tidal volume is set at 7 mL/kg predicted body weight and, during OLV, it will be decreased to 5 mL/kg. The occurrence of PPC will be recorded as a collapsed composite of single adverse pulmonary events and represents the primary endpoint. Discussion: PROTHOR is the first randomized controlled trial in patients undergoing thoracic surgery with OLV that is adequately powered to compare the effects of intraoperative high PEEP with RM versus low PEEP without RM on PPC. The results of the PROTHOR trial will support anesthesiologists in their decision to set intraoperative PEEP during protective ventilation for OLV in thoracic surgery. Trial registration: The trial was registered in clinicaltrials.gov (NCT02963025) on 15 November 2016.

Published
2019

23. Correction to: Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): Study protocol for a randomized controlled trial (Trials (2019) 20: 213 DOI: 10.1186/s13063-019-3208-8)

Author

Kiss T., Wittenstein J., Becker C., Birr K., Cinnella G., Cohen E., El Tahan M. R., Falcao L. F., Gregoretti C., Granell M., Hachenberg T., Hollmann M. W., Jankovic R., Karzai W., Krassler J., Loop T., Licker M. J., Marczin N., Mills G. H., Murrell M. T., Neskovic V., Nisnevitch-Savarese Z., Pelosi P., Rossaint R., Schultz M. J., Neto A. S., Severgnini P., Szegedi L., Vegh T., Voyagis G., Zhong J., De Abreu M. G., Senturk M., Kiss T., Wittenstein J., Becker C., Birr K., Cinnella G., Cohen E., El Tahan M.R., Falcao L.F., Gregoretti C., Granell M., Hachenberg T., Hollmann M.W., Jankovic R., Karzai W., Krassler J., Loop T., Licker M.J., Marczin N., Mills G.H., Murrell M.T., Neskovic V., Nisnevitch-Savarese Z., Pelosi P., Rossaint R., Schultz M.J., Neto A.S., Severgnini P., Szegedi L., Vegh T., Voyagis G., Zhong J., De Abreu M.G., and Senturk M.

Subjects
protective ventilation, Medicine (miscellaneous), Pharmacology (medical)
Abstract

After publication of the original article [1], the authors have notified us that two of the collaborator first and last names have been inverted in the "PROTHOR Investigators" table. The correct information is: Surname: Spadaro Name: Savino Surname Vitali Name Costanza The original article has been corrected.

Published
2019

24. The effects of personality on the appraisal of technology related stressors as techno-distress and techno-eustress

Author

van der Loop, T. (Tim)

Subjects
Technostress, Technology, Stressor, Distress, Eustress, Appraisal, Personality
Abstract

In this age of increasing digitalization and rapid changes in technology, ICT professionals who find it difficult to cope with these changes experience the effects as technostress. A common assumption of technostress studies is that technostress has predominantly negative effects on the individuals experiencing it. However, in psychological stress literature it is argued that individuals can cognitively appraise stressful situations in a positively and negatively way. This study draws on this dualistic view of stress and aims to identify which individual level characteristics impact an individual’s appraisal of technology related stressors as either eustress or distress. The results of this study indicate that individual level characteristics by themselves do not impact an individual’s appraisal of technology related stressors and calls for deeper examining the role of other contextual external factors that impact an individual’s appraisal of technology related stressors as either eustress or distress.

Published
2020

26. Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial

Author

Kiss, T., Wittenstein, J., Becker, C., Birr, K., Cinnella, G., Cohen, E., El Tahan, M. R., Falcao, L. F., Gregoretti, C., Granell, M., Hachenberg, T., Hollmann, M. W., Jankovic, R., Karzai, W., Krassler, J., Loop, T., Licker, M. J., Marczin, N., Mills, G. H., Murrell, M. T., Neskovic, V., Nisnevitch-Savarese, Z., Pelosi, P., Rossaint, R., Schultz, M. J., Serpa Neto, A., Severgnini, P., Szegedi, L., Vegh, T., Voyagis, G., Zhong, J., Gama De Abreu, M., Senturk, M., and Noto, Alberto

Subjects
Positive-Pressure Respiration, Mechanical ventilation, one-lung ventilation, positive end-expiratory pressure, postoperative pulmonary complication, recruitment maneuver, thoracic surgery, Humans, Intraoperative Complications, One-Lung Ventilation, Research Design, Sample Size, Thoracic Surgical Procedures, Randomized Controlled Trials as Topic, Correction
Abstract

Postoperative pulmonary complications (PPC) may result in longer duration of in-hospital stay and even mortality. Both thoracic surgery and intraoperative mechanical ventilation settings add considerably to the risk of PPC. It is unclear if one-lung ventilation (OLV) for thoracic surgery with a strategy of intraoperative high positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) reduces PPC, compared to low PEEP without RM.PROTHOR is an international, multicenter, randomized, controlled, assessor-blinded, two-arm trial initiated by investigators of the PROtective VEntilation NETwork. In total, 2378 patients will be randomly assigned to one of two different intraoperative mechanical ventilation strategies. Investigators screen patients aged 18 years or older, scheduled for open thoracic or video-assisted thoracoscopic surgery under general anesthesia requiring OLV, with a maximal body mass index of 35 kg/mPROTHOR is the first randomized controlled trial in patients undergoing thoracic surgery with OLV that is adequately powered to compare the effects of intraoperative high PEEP with RM versus low PEEP without RM on PPC. The results of the PROTHOR trial will support anesthesiologists in their decision to set intraoperative PEEP during protective ventilation for OLV in thoracic surgery.The trial was registered in clinicaltrials.gov ( NCT02963025 ) on 15 November 2016.

Published
2018

32. Einlungenventilation.

Author

Loop, T.

Abstract

Copyright of Anaesthesiologie & Intensivmedizin is the property of DGAI e.V. - Deutsche Gesellschaft fur Anasthesiologie und Intensivmedizin e.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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33. Rapid sequence induction and intubation in patients with risk of aspiration. Recommendations for action for practical management of anesthesia

Author

Eichelsbacher, C., Ilper, H., Noppens, R., Hinkelbein, J., Loop, T., Eichelsbacher, C., Ilper, H., Noppens, R., Hinkelbein, J., and Loop, T.

Abstract

Induction of general anesthesia in patients with risk for aspiration needs special considerations to avoid the incidence and severity of complications. Since no evidence-based guidelines support the challenge for anesthesiologists various practical recommendations exist in clinical practice for rapid sequence induction and intubation (RSI). The aim of this systematic review is, to summarize the evidence and recommend a decision making process. Multilevel RAND-delphi-method (RAND: Research and Development) combined with systematic literature research, individual assessment and evaluation, consensus conferences and final common sequence. The consideration of all practical, clinical procedures in patients at risk for aspiration represents an effective prevention of pulmonary aspiration during the induction of anesthesia. These include the optimal drug pre-treatment with antacids (e.g. sodium citrate) for highly aspiration-endangered and proton pump inhibitors or H2 blockers in other patients the evening before. Each patient should be examined and explained prior to RSI according to the recommendations of the National German Society of Anesthesiology for preoperative evaluation. A RSI should be performed in patients with no 2h liquid and no 6h food fasting or acute vomiting, sub-ileus or ileus, or no protective reflexes or a gastrointestinal passenger disorder. In addition, RSI should be performed in pregnant women after the 3rd trimester and during birth. The expertise and competence of the physician before and during rapid sequence induction and intubation about the respective task distribution minimizes the risk of aspiration, as does the adequate equipment, as well as an optimized upper body elevation of the patient. Consistent pre-oxygenation with an FIO2 of 1.0 (FetO2-concentration 0.9) and an oxygen flow 10 l/min using a completely sealing respiratory mask with capnography should take 3-5 minutes. Fast enough deep anesthesia and muscle relaxation to avoid coughin

Published
2018

34. Anaesthesia management for bronchoscopic and surgical lung volume reduction

Author

Grande, Bastian, Loop, T, Grande, Bastian, and Loop, T

Abstract

Optimizing the patient’s condition before the lung volume reduction (LVR) according to recommendations by American College of Cardiology/American Heart Association (ACC/AHA) guideline on perioperative cardiovascular evaluation is mandatory. Implementation of a multimodal analgesia concept and the use short-acting anaesthetics enhances recovery and avoids postoperative pulmonary complications. Normovolemia, normothermia, lung protective ventilation and an evidence-based concept of airway management (i.e., double-lumen tube, bronchus blocker) are suggested for intraoperative management of surgical lung volume reduction (SLVR). General anaesthesia (using remifentanil, propofol and mivacurium) with an i-gel® supraglottic airway device should be used for bronchoscopic lung volume reduction (BLVR). Jet ventilation through rigid bronchoscopy or with a jet catheter may be an alternative concept. Experienced consultants should perform anaesthesia for LVR.

Published
2018

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