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1. An Efficient Black-Box Support of Advanced Coverage Criteria for Klee

Author

Berthier, Nicolas, De Oliveira, Steven, Kosmatov, Nikolai, Longuet, Delphine, and Soulat, Romain

Subjects
Computer Science - Software Engineering, 68M15
Abstract

Dynamic symbolic execution (DSE) is a powerful test generation approach based on an exploration of the path space of the program under test. Well-adapted for path coverage, this approach is however less efficient for conditions, decisions, advanced coverage criteria (such as multiple conditions, weak mutations, boundary testing) or user-provided test objectives. While theoretical solutions to adapt DSE to a large set of criteria have been proposed, they have never been integrated into publicly available testing tools. This paper presents a first integration of an optimized test generation strategy for advanced coverage criteria into a popular open-source testing tool based on DSE, namely, Klee. The integration is performed in a fully black-box manner, and can therefore inspire an easy integration into other similar tools. The resulting version of the tool, named Klee4labels, is publicly available. We present the design of the proposed technique and evaluate it on several benchmarks. Our results confirm the benefits of the proposed tool for advanced coverage criteria., Comment: 15 pages

Published
2022
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4. Use of a Belatacept-based Immunosuppression for Kidney Transplantation From Donors After Circulatory Death: A Paired Kidney Analysis

Author

Rita Eid, MD, Anne Scemla, MD, Magali Giral, MD, PhD, Nadia Arzouk, MD, Dominique Bertrand, MD, Marie-Noëlle Peraldi, MD, PhD, Laurent Mesnard, MD, PhD, Helene Longuet, MD, Mehdi Maanaoui, MD, PhD, Geoffroy Desbuissons, MD, Edouard Lefevre, MD, and Renaud Snanoudj, MD, PhD

Subjects
Surgery, RD1-811
Abstract

Background. Efficacy and safety of belatacept have not been specifically reported for kidney transplantations from donors after circulatory death. Methods. In this retrospective multicenter paired kidney study, we compared the outcome of kidney transplantations with a belatacept-based to a calcineurin inhibitor (CNI)-based immunosuppression. We included all kidney transplant recipients from donors after uncontrolled or controlled circulatory death performed in our center between February 2015 and October 2020 and treated with belatacept (n = 31). The control group included the recipients of the contralateral kidney that were treated with CNI in 8 other centers (tacrolimus n = 29, cyclosporine n = 2). Results. There was no difference in the rate of delayed graft function. A higher incidence of biopsy-proven rejections was noted in the belatacept group (24 versus 6 episodes). Estimated glomerular filtration rate (eGFR) was significantly higher in the belatacept group at 3-, 12-, and 36-mo posttransplant, but the slope of eGFR was similar in the 2 groups. During a mean follow-up of 4.1 y, 12 patients discontinued belatacept and 2 patients were switched from CNI to belatacept. For patients who remained on belatacept, eGFR mean value and slope were significantly higher during the whole follow-up. At 5 y, eGFR was 80.7 ± 18.5 with belatacept versus 56.3 ± 22.0 mL/min/1.73 m2 with CNI (P = 0.003). No significant difference in graft and patient survival was observed. Conclusions. The use of belatacept for kidney transplants from either uncontrolled or controlled donors after circulatory death resulted in a better medium-term renal function for patients remaining on belatacept despite similar rates of delayed graft function and higher rates of cellular rejection.

Published
2024
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5. Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trialsResearch in context

Author

Ilias I. Siempos, Andre C. Kalil, Drifa Belhadi, Viviane Cordeiro Veiga, Alexandre Biasi Cavalcanti, Westyn Branch-Elliman, Eleni Papoutsi, Konstantinos Gkirgkiris, Nikoleta A. Xixi, Anastasia Kotanidou, Olivier Hermine, Raphaël Porcher, Xavier Mariette, Philippe Ravaud, Serge Bureau, Maxime Dougados, Matthieu Resche-Rigon, Pierre-Louis Tharaux, Annick Tibi, Elie Azoulay, Jacques Cadranel, Joseph Emmerich, Muriel Fartoukh, Bertrand Guidet, Marc Humbert, Karine Lacombe, Matthieu Mahevas, Frédéric Pene, Valerie Pourchet-Martinez, Frédéric Schlemmer, Yazdan Yazdanpanah, Gabriel Baron, Elodie Perrodeau, Damien Vanhoye, Cécile Kedzia, Lauren Demerville, Anne Gysembergh-Houal, Alexandre Bourgoin, Nabil Raked, Lakhdar Mameri, Claire Montlahuc, Lucie Biard, St.phanie Alary, Samir Hamiria, Thinhinane Bariz, Hala Semri, Dhiaa Meriem Hai, Moustafa Benafla, Mohamed Belloul, Pernelle Vauboin, Saskia Flamand, Claire Pacheco, Anouk Walter-Petrich, Emilia Stan, Souad Benarab, Corine Nyanou, Robin Charreteur, Céline Dupre, Kévin Cardet, Blandine Lehmann, Kamyl Baghli, Claire Madelaine, Eric D'Ortenzio, Oriane Puéchal, Caroline Semaille, Laurent Savale, Anatole Harrois, Samy Figueiredo, Jacques Duranteau, Nadia Anguel, Arthur Pavot, Xavier Monnet, Christian Richard, Jean-Louis Teboul, Philippe Durand, Pierre Tissieres, Mitja Jevnikar, David Montani, Stephan Pavy, Gaétane Nocturne, Samuel Bitoun, Nicolas Noel, Olivier Lambotte, Lelia Escaut, Stephane Jauréguiberry, Elodie Baudry, Christiane Verny, Edouard Lefevre, Mohamad Zaidan, Domitille Molinari, Gaël Leprun, Alain Fourreau, Laurent Cylly, Lamiae Grimaldi, Myriam Virlouvet, Ramdane Meftali, Soléne Fabre, Marion Licois, Asmaa Mamoune, Yacine Boudali, Clotilde Le Tiec, Céline Verstuyft, Anne-Marie Roques, Sophie Georgin-Lavialle, Patricia Senet, Gilles Pialoux, Angele Soria, Antoine Parrot, Helene François, Nathalie Rozensztajn, Emmanuelle Blin, Pascaline Choinier, Juliette Camuset, Jean-Simon Rech, Antony Canellas, Camille Rolland-Debord, Nadege Lemarié, Nicolas Belaube, Marine Nadal, Martin Siguier, Camille Petit-Hoang, Julie Chas, Elodie Drouet, Matthieu Lemoine, Audrey Phibel, Lucie Aunay, Eliane Bertrand, Sylviane Ravato, Marie Vayssettes, Anne Adda, Celine Wilpotte, Pélagie Thibaut, Julie Fillon, Isabelle Debrix, Soraya Fellahi, Jean-Philippe Bastard, Guillaume Lefévre, Jacques-Eric Gottenberg, Yves Hansmann, Frédéric Blanc, Sophie Ohlmann-Caillard, Vincent Castelain, Emmanuel Chatelus, Eva Chatron, Olivier Collange, François Danion, Frédéric De Blay, Pierre Diemunsch, Sophie Diemunsch, Renaud Felten, Bernard Goichot, Valentin Greigert, Aurelien Guffroy, Bob Heger, Charlotte Kaeuffer, Loic Kassegne, Anne Sophie Korganow, Pierrick Le Borgne, Nicolas Lefebvre, Paul-Michel Mertes, Eric Noll, Mathieu Oberlin, Vincent Poindron, Julien Pottecher, Yvon Ruch, François Weill, Nicolas Meyer, Emmanuel Andres, Eric Demonsant, Hakim Tayebi, Gabriel Nisand, Stéphane Brin, Cédric Sublon, Guillaume Becker, Anne Hutt, Tristan Martin, Sophie Bayer, Catherine Metzger, Arsene Mekinian, Noémie Abisror, Amir Adedjouma, Diane Bollens, Marion Bonneton, Nathalie Bourcicaux, Anne Bourrier, Maria Chauchard Thibault Chiarabiani, Doroth.e Chopin, Jonathan Cohen, Ines Devred, Bruno Donadille, Olivier Fain, Geoffrey Hariri, Vincent Jachiet, Patrick Ingliz, Marc Garnier, Marc Gatfosse, Etienne Ghrenassia, Delphine Gobert, Jessica Krause le Garrec, Cecilia Landman, Jean Remy Lavillegrand, Benedicte Lefebvre, Thibault Mahevas, Sandie Mazerand, Jean Luc Meynard, Marjolaine Morgand, Zineb Ouaz.ne, Jerome Pacanowski, S.bastien Riviere, Philippe Seksik, Harry Sokol, Heithem Soliman, Nadia Valin, Thomas Urbina, Chloé McAvoy, Maria Pereira Miranda, Gladys Aratus, Laurence Berard, Tabassome Simon, Anne Daguenel Nguyen, Elise Girault, Cl.mentine Mayala-Kanda, Marie Antignac, Céline Leplay, Jean-Benoit Arlet, Jean-Luc Diehl, Florence Bellenfant, Anne Blanchard, Alexandre Buffet, Bernard Cholley, Antoine Fayol, Edouard Flamarion, Anne Godier, Thomas Gorget, Sophie-Rym Hamada, Caroline Hauw-Berlemont, Jean-Sébastien Hulot, David Lebeaux, Marine Livrozet, Adrien Michon, Arthur Neuschwander, Marie-Aude Pennet, Benjamin Planquette, Brigitte Ranque, Olivier Sanchez, Geoffroy Volle, Sandrine Briois, Mathias Cornic, Virginie Elisee, Jesuthasan Denis, Juliette Djadi-Prat, Pauline Jouany, Ramon Junquera, Mickael Henriques, Amina Kebir, Isabelle Lehir, Jeanne Meunier, Florence Patin, Val.rie Paquet, Anne Tréhan, Véronique Vigna, Brigitte Sabatier, Damien Bergerot, Charléne Jouve, Camille Knosp, Olivia Lenoir, Nassim Mahtal, Léa Resmini, Xavier Lescure, Jade Ghosn, Antoine Bachelard, Anne Rachline, Valentina Isernia, Bao-chau, Phung, Dorothée Vallois, Aurelie Sautereau, Catherine Neukrich, Antoine Dossier, Raphaël Borie, Bruno Crestani, Gregory Ducrocq, Philippe Gabriel Steg, Philippe Dieude, Thomas Papo, Estelle Marcault, Marhaba Chaudhry, Charléne Da Silveira, Annabelle Metois, Ismahan Mahenni, Meriam Meziani, Cyndie Nilusmas, Sylvie Le Gac, Awa Ndiaye, Fran.oise Louni, Malikhone Chansombat, Zelie Julia, Solaya Chalal, Lynda Chalal, Laura Kramer, Jeniffer Le Grand, Kafif Ouifiya, Valentine Piquard, Sarah Tubiana, Yann Nguyen, Vasco Honsel, Emmanuel Weiss, Anais Codorniu, Virginie Zarrouk, Victoire de Lastours, Matthieu Uzzan, Naura Gamany, Agathe Claveirole, Alexandre Navid, Tiffanie Fouque, Yonathan Cohen, Maya Lupo, Constance Gilles, Roza Rahli, Zeina Louis, David Boutboul, Lionel Galicier, Yaël Amara, Gabrielle Archer, Amira Benattia, Anne Bergeron, Louise Bondeelle, Nathalie de Castro, Melissa Clément, Michaël Darmon, Blandine Denis, Clairelyne Dupin, Elsa Feredj, Delphine Feyeux, Adrien Joseph, Etienne Lenglin, Pierre Le Guen, Geoffroy Liégeon, Gwenaël Lorillon, Asma Mabrouki, Eric Mariotte, Grégoire Martin de Frémont, Adrien Mirouse, Jean-Michel Molina, Régis Peffault de Latour, Eric Oksenhendler, Julien Saussereau, Abdellatif Tazi, Jean-Jacques Tudesq, Lara Zafrani, Isabelle Brindele, Emmanuelle Bugnet, Karine Celli Lebras, Julien Chabert, Lamia Djaghout, Catherine Fauvaux, Anne Lise Jegu, Ewa Kozakiewicz, Martine Meunier, Marie-Thérèse Tremorin, Claire Davoine, Isabelle Madelaine, Sophie Caillat-Zucman, Constance Delaugerre, Florence Morin, Damien Sène, Ruxandra Burlacu, Benjamin Chousterman, Bruno Mégarbanne, Pascal Richette, Jean-Pierre Riveline, Aline Frazier, Eric Vicaut, Laure Berton, Tassadit Hadjam, Miguel Alejandro Vazquez-Ibarra, Clément Jourdaine, Olivia Tran, Véronique Jouis, Aude Jacob, Julie Smati, Stéphane Renaud, Claire Pernin, Lydia Suarez, Luca Semerano, Sébastien Abad, Ruben B. nainous, Nicolas Bonnet, Celine Comparon, Yves Cohen, Hugues Cordel, Robin Dhote, Nathalie Dournon, Boris Duchemann, Nathan Ebstein, Thomas Gille, Benedicte Giroux-Leprieur, Jeanne Goupil de Bouille, Hilario Nunes, Johanna Oziel, Dominique Roulot, Lucile Sese, ClaireTantet, Yurdagul Uzunhan, Coralie Bloch-Queyrat, Vincent Levy, Fadhila Messani, Mohammed Rahaoui, Myléne Petit, Sabrina Brahmi, Vanessa Rathoin, Marthe Rigal, Nathalie Costedoat-Chalumeau, Liem Binh Luong, Zakaria Ait Hamou, Sarah Benghanem, Philippe Blanche, Nicolas Carlier, Benjamin Chaigne, Remy Gauzit, Hassan Joumaa, Mathieu Jozwiak, Marie Lachétre, Hélène Lafoeste, Odie Launay, Paul Legendre, Jonathan Marey, Caroline Morbieu, Lola-Jade Palmieri, Tali-Anne Szwebel, Hendy Abdoul, Alexandra Bruneau, Audrey Beclin-Clabaux, Charly Larrieu, Pierre Montanari, Eric Dufour, Ada Clarke, Catherine Le Bourlout, Nathalie Marin, Nathalie Menage, Samira Saleh-Mghir, Mamadou Salif Cisse, Kahina Cheref, Corinne Guerin, Jérémie Zerbit, Marc Michel, Sébastien Gallien, Etienne Crickx, Benjamin Le Vavasseur, Emmanuelle Kempf, Karim Jaffal, William Vindrios, Julie Oniszczuk, Constance Guillaud, Pascal Lim, Elena Fois, Giovanna Melica, Marie Matignon, Maud Jalabert, Jean-Daniel Lelièvre, David Schmitz, Marion Bourhis, Sylia Belazouz, Laetitia Languille, Caroline Boucle, Nelly Cita, Agnés Didier, Fahem Froura, Katia Ledudal, Thiziri Sadaoui, Alaki Thiemele, Delphine Le Febvre De Bailly, Muriel Carvhalo Verlinde, Julien Mayaux, Patrice Cacoub, David Saadoun, Mathieu Vautier, Héléne Bugaut, Olivier Benveniste, Yves Allenbach, Gaëlle Leroux, Aude Rigolet, Perrine Guillaume-Jugnot, Fanny Domont, Anne Claire Desbois, Chloé Comarmond, Nicolas Champtiaux, Segolene Toquet, Amine Ghembaza, Matheus Vieira, Georgina Maalouf, Goncalo Boleto, Yasmina Ferfar, Jean-Christophe Corvol, C.line Louapre, Sara Sambin, Louise-Laure Mariani, Carine Karachi, Florence Tubach, Candice Estellat, Linda Gimeno, Karine Martin, Aicha Bah, Vixra Keo, Sabrine Ouamri, Yasmine Messaoudi, Nessima Yelles, Pierre Faye, Sebastien Cavelot, Cecile Larcheveque, Laurence Annonay, Jaouad Benhida, Aida Zahrate-Ghoul, Soumeya Hammal, Ridha Belilita, Fanny Charbonnier, Claire Aguilar, Fanny Alby-Laurent, Carole Burger, Clara Campos-Vega, Nathalie Chavarot, Benjamin Fournier, Claire Rouzaud, Damien Vimpére, Caroline Elie, Prissile Bakouboula, Laure Choupeaux, Sophie Granville, Elodie Issorat, Christine Broissand, Marie-Alexandra Alyanakian, Guillaume Geri, Nawal Derridj, Naima Sguiouar, Hakim Meddah, Mourad Djadel, Héléne Chambrin-Lauvray, Jean-Charles Duclos-vallée, Faouzi Saliba, Sophie-Caroline Sacleux, Ilias Kounis, Sonia Tamazirt, Eric Rudant, Jean-Marie Michot, Annabelle Stoclin, Emeline Colomba, Fanny Pommeret, Christophe Willekens, Rosa Da Silva, Valérie Dejean, Yasmina Mekid, Ines Ben-Mabrouk, Florence Netzer, Caroline Pradon, Laurence Drouard, Valérie Camara-Clayette, Alexandre Morel, Gilles Garcia, Abolfazl Mohebbi, Férial Berbour, Mélanie Dehais, Anne-Lise Pouliquen, Alison Klasen, Loren Soyez-Herkert, Jonathan London, Younes Keroumi, Emmanuelle Guillot, Guillaume Grailles, Younes El amine, Fanny Defrancq, Hanane Fodil, Chaouki Bouras, Dominique Dautel, Nicolas Gambier, Thierno Dieye, Boris Bienvenu, Victor Lancon, Laurence Lecomte, Kristina Beziriganyan, Belkacem Asselate, Laure Allanic, Elena Kiouris, Marie-Héléne Legros, Christine Lemagner, Pascal Martel, Vincent Provitolo, Félix Ackermann, Mathilde Le Marchand, Aurélie Chan Hew Wai, Dimitri Fremont, Elisabeth Coupez, Mireille Adda, Frédéric Duée, Lise Bernard, Antoine Gros, Estelle Henry, Claire Courtin, Anne Pattyn, Pierre-Grégoire Guinot, Marc Bardou, Agnes Maurer, Julie Jambon, Amélie Cransac, Corinne Pernot, Bruno Mourvillier, Eric Marquis, Philippe Benoit, Damien Roux, Coralie Gernez, Cécile Yelnik, Julien Poissy, Mandy Nizard, Fanette Denies, Helene Gros, Jean-Jacques Mourad, Emmanuelle Sacco, Sophie Renet, F. Ader, Y. Yazdanpanah, F. Mentre, N. Peiffer-Smadja, F.X. Lescure, J. Poissy, L. Bouadma, J.F. Timsit, B. Lina, F. Morfin-Sherpa, M. Bouscambert, A. Gaymard, G. Peytavin, L. Abel, J. Guedj, C. Andrejak, C. Burdet, C. Laouenan, D. Belhadi, A. Dupont, T. Alfaiate, B. Basli, A. Chair, S. Laribi, J. Level, M. Schneider, M.C. Tellier, A. Dechanet, D. Costagliola, B. Terrier, M. Ohana, S. Couffin-Cadiergues, H. Esperou, C. Delmas, J. Saillard, C. Fougerou, L. Moinot, L. Wittkop, C. Cagnot, S. Le Mestre, D. Lebrasseur-Longuet, V. Petrov-Sanchez, A. Diallo, N. Mercier, V. Icard, B. Leveau, S. Tubiana, B. Hamze, A. Gelley, M. Noret, E. D’Ortenzio, O. Puechal, C. Semaille, T. Welte, J.A. Paiva, M. Halanova, M.P. Kieny, E. Balssa, C. Birkle, S. Gibowski, E. Landry, A. Le Goff, L. Moachon, C. Moins, L. Wadouachi, C. Paul, A. Levier, D. Bougon, F. Djossou, L. Epelboin, J. Dellamonica, C.H. Marquette, C. Robert, S. Gibot, E. Senneville, V. Jean-Michel, Y. Zerbib, C. Chirouze, A. Boyer, C. Cazanave, D. Gruson, D. Malvy, P. Andreu, J.P. Quenot, N. Terzi, K. Faure, C. Chabartier, V. Le Moing, K. Klouche, T. Ferry, F, Valour, B. Gaborit, E. Canet, P. Le Turnier, D. Boutoille, F. Bani-Sadr, F. Benezit, M. Revest, C. Cameli, A. Caro, MJ Ngo Um Tegue, Y. Le Tulzo, B. Laviolle, F. Laine, G. Thiery, F. Meziani, Y. Hansmann, W. Oulehri, C. Tacquard, F. Vardon-Bounes, B. Riu-Poulenc, M. Murris-Espin, L. Bernard, D. Garot, O. Hinschberger, M. Martinot, C. Bruel, B. Pilmis, O. Bouchaud, P. Loubet, C. Roger, X. Monnet, S. Figueiredo, V. Godard, J.P. Mira, M. Lachatre, S. Kerneis, J. Aboab, N. Sayre, F. Crockett, D. Lebeaux, A. Buffet, J.L. Diehl, A. Fayol, J.S. Hulot, M. Livrozet, A Mekontso- Dessap, C. Ficko, F. Stefan, J. Le Pavec, J. Mayaux, H. Ait-Oufella, J.M. Molina, G. Pialoux, M. Fartoukh, J. Textoris, M. Brossard, A. Essat, E. Netzer, Y. Riault, M. Ghislain, L. Beniguel, M. Genin, L. Gouichiche, C. Betard, L. Belkhir, A. Altdorfer, V Fraipont Centro, S. Braz, JM Ferreira Ribeiro, R Roncon Alburqueque, M. Berna, M. Alexandre, B. Lamprecht, A. Egle, R. Greil, M. Joannidis, Thomas F. Patterson, Philip O. Ponce, Barbara S. Taylor, Jan E. Patterson, Jason E. Bowling, Heta Javeri, LuAnn Larson, Angela Hewlett, Aneesh K. Mehta, Nadine G. Rouphael, Youssef Saklawi, Nicholas Scanlon, Jessica J. Traenkner, Ronald P. Trible, Jr., Emmanuel B. Walter, Noel Ivey, Thomas L. Holland, Guillermo M. Ruiz-Palacios, Alfredo Ponce de León, Sandra Rajme, Lanny Hsieh, Alpesh N. Amin, Miki Watanabe, Helen S. Lee, Susan Kline, Joanne Billings, Brooke Noren, Hyun Kim, Tyler D. Bold, Victor Tapson, Jonathan Grein, Fayyaz Sutterwala, Nicole Iovine, Lars K. Beattie, Rebecca Murray Wakeman, Matthew Shaw, Mamta K. Jain, Satish Mocherla, Jessica Meisner, Amneris Luque, Daniel A. Sweeney, Constance A. Benson, Farhana Ali, Robert L. Atmar, Hana M. El Sahly, Jennifer Whitaker, Ann R. Falsey, Angela R. Branche, Cheryl Rozario, Justino Regalado Pineda, José Arturo Martinez-Orozco, David Chien Lye, Sean WX. Ong, Po Ying Chia, Barnaby E. Young, Uriel Sandkovsky, Mezgebe Berhe, Clinton Haley, Emma Dishner, Valeria D. Cantos, Colleen F. Kelley, Paulina A. Rebolledo Esteinou, Sheetal Kandiah, Sarah B. Doernberg, Pierre-Cedric B. Crouch, Hannah Jang, Anne F. Luetkemeyer, Jay Dwyer, Stuart H. Cohen, George R. Thompson, 3rd, Hien H. Nguyen, Robert W. Finberg, Jennifer P. Wang, Juan Perez-Velazquez, Mireya Wessolossky, Patrick E.H. Jackson, Taison D. Bell, Miranda J. West, Babafemi Taiwo, Karen Krueger, Johnny Perez, Triniece Pearson, Catharine I. Paules, Kathleen G. Julian, Danish Ahmad, Alexander G. Hajduczok, Henry Arguinchona, Christa Arguinchona, Nathaniel Erdmann, Paul Goepfert, Neera Ahuja, Maria G. Frank, David Wyles, Heather Young, Myoung-don Oh, Wan Beom Park, Chang Kyung Kang, Vincent Marconi, Abeer Moanna, Sushma Cribbs, Telisha Harrison, Eu Suk Kim, Jongtak Jung, Kyoung-Ho Song, Hong Bin Kim, Seow Yen Tan, Humaira Shafi, MF Jaime Chien, Raymond KC. Fong, Daniel D. Murray, Jens Lundgren, Henrik Nielsen, Tomas Jensen, Barry S. Zingman, Robert Grossberg, Paul F. Riska, Otto O. Yang, Jenny Ahn, Rubi Arias, Rekha R. Rapaka, Naomi Hauser, James D. Campbell, William R. Short, Pablo Tebas, Jillian T. Baron, Susan L.F. McLellan, Lucas S. Blanton, Justin B. Seashore, C. Buddy Creech, Todd W. Rice, Shannon Walker, Isaac P. Thomsen, Diego Lopez de Castilla, Jason W. Van Winkle, Francis X. Riedo, Surinder Kaur Pada, Alvin DY. Wang, Li Lin, Michelle Harkins, Gregory Mertz, Nestor Sosa, Louis Yi Ann Chai, Paul Anantharajah Tambyah, Sai Meng Tham, Sophia Archuleta, Gabriel Yan, David A. Lindholm, Ana Elizabeth Markelz, Katrin Mende, Richard Mularski, Elizabeth Hohmann, Mariam Torres-Soto, Nikolaus Jilg, Ryan C. Maves, Gregory C. Utz, Sarah L. George, Daniel F. Hoft, James D. Brien, Roger Paredes, Lourdes Mateu, Cora Loste, Princy Kumar, Sarah Thornton, Sharmila Mohanraj, Noreen A. Hynes, Lauren M. Sauer, Christopher J. Colombo, Christina Schofield, Rhonda E. Colombo, Susan E. Chambers, Richard M. Novak, Andrea Wendrow, Samir K. Gupta, Tida Lee, Tahaniyat Lalani, Mark Holodniy, Aarthi Chary, Nikhil Huprikar, Anuradha Ganesan, Norio Ohmagari, Ayako Mikami, D. Ashley Price, Christopher J.A. Duncan, Kerry Dierberg, Henry J. Neumann, Stephanie N. Taylor, Alisha Lacour, Najy Masri, Edwin Swiatlo, Kyle Widmer, James D. Neaton, Mary Bessesen, David S. Stephens, Timothy H. Burgess, Timothy M. Uyeki, Robert Walker, G. Lynn Marks, Anu Osinusi, Huyen Cao, Anabela Cardoso, Stephanie de Bono, Douglas E. Schlichting, Kevin K. Chung, Jennifer L. Ferreira, Michelle Green, Mat Makowski, Michael R. Wierzbicki, Tom M. Conrad, Jill Ann El-Khorazaty, Heather Hill, Tyler Bonnett, Nikki Gettinger, Theresa Engel, Teri Lewis, Jing Wang, John H. Beigel, Kay M. Tomashek, Varduhi Ghazaryan, Tatiana Beresnev, Seema Nayak, Lori E. Dodd, Walla Dempsey, Effie Nomicos, Marina Lee, Rhonda Pikaart-Tautges, Mohamed Elsafy, Robert Jurao, Hyung Koo, Michael Proschan, Tammy Yokum, Janice Arega, Ruth Florese, Jocelyn D. Voell, Richard Davey, Ruth C. Serrano, Zanthia Wiley, Varun K. Phadke, Paul A. Goepfert, Carlos A. Gomez, Theresa A. Sofarelli, Laura Certain, Hannah N. Imlay, Cameron R. Wolfe, Emily R. Ko, John J. Engemann, Nora Bautista Felix, Claire R. Wan, Sammy T. Elmor, Laurel R. Bristow, Michelle S. Harkins, Nicole M. Iovine, Marie-Carmelle Elie-Turenne, Victor F. Tapson, Pyoeng Gyun Choe, Richard A. Mularski, Kevin S. Rhie, Rezhan H. Hussein, Dilek Ince, Patricia L. Winokur, Jin Takasaki, Sho Saito, Kimberly McConnell, PharmD, David L. Wyles, Ellen Sarcone, Kevin A. Grimes, Katherine Perez, Charles Janak, Jennifer A. Whitaker, Paulina A. Rebolledo, John Gharbin, Allison A. Lambert, Diego F. Zea, Emma Bainbridge, David C. Hostler, Jordanna M. Hostler, Brian T. Shahan, Evelyn Ling, Minjoung Go, Fleesie A. Hubbard, Melony Chakrabarty, Maryrose Laguio-Vila, Edward E. Walsh, Faheem Guirgis, Vincent C. Marconi, Christian Madar, Scott A. Borgetti, Corri Levine, Joy Nock, Keith Candiotti, Julia Rozman, Fernando Dangond, Yann Hyvert, Andrea Seitzinger, Kaitlyn Cross, Stephanie Pettibone, Seema U. Nayak, and Gregory A. Deye

Subjects
Acute respiratory distress syndrome, Acute hypoxemic respiratory failure, Pneumonia, Critically ill, Cancer, Medicine (General), R5-920
Abstract

Summary: Background: Although immunomodulators have established benefit against the new coronavirus disease (COVID-19) in general, it is uncertain whether such agents improve outcomes without increasing the risk of secondary infections in the specific subgroup of previously immunocompromised patients. We assessed the effect of immunomodulators on outcomes of immunocompromised patients hospitalized for COVID-19. Methods: The protocol was prospectively registered with PROSPERO (CRD42022335397). MEDLINE, Cochrane Central Register of Controlled Trials and references of relevant articles were searched up to 01-06-2022. Authors of potentially eligible randomized controlled trials were contacted to provide data on immunocompromised patients randomized to immunomodulators vs control (i.e., placebo or standard-of-care). Findings: Eleven randomized controlled trials involving 397 immunocompromised patients hospitalized for COVID-19 were included. Ten trials had low risk of bias. There was no difference between immunocompromised patients randomized to immunomodulators vs control regarding mortality [30/182 (16.5%) vs 41/215 (19.1%); RR 0.93, 95% CI 0.61–1.41; p = 0.74], secondary infections (RR 1.00, 95% CI 0.64–1.58; p = 0.99) and change in World Health Organization ordinal scale from baseline to day 15 (weighed mean difference 0.27, 95% CI -0.09–0.63; p = 0.15). In subgroup analyses including only patients with hematologic malignancy, only trials with low risk of bias, only trials administering IL-6 inhibitors, or only trials administering immunosuppressants, there was no difference between comparators regarding mortality. Interpretation: Immunomodulators, compared to control, were not associated with harmful or beneficial outcomes, including mortality, secondary infections, and change in ordinal scale, when administered to immunocompromised patients hospitalized for COVID-19. Funding: Hellenic Foundation for Research and Innovation.

Published
2024
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6. Thrombotic microangiopathies after kidney transplantation in modern era: nosology based on chronology

Author

Florent Von Tokarski, Alexandre Fillon, Valentin Maisons, Benjamin Thoreau, Guillaume Bayer, Philippe Gatault, Hélène Longuet, Bénédicte Sautenet, Matthias Buchler, Cécile Vigneau, Fadi Fakhouri, and Jean-Michel Halimi

Subjects
Kidney transplantation, Malignant hypertension, Hemolytic uremic syndrome, Infection, Outcomes, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Thrombotic microangiopathies (TMAs) are rare but can be severe in kidney transplant. recipients (KTR). Methods We analysed the epidemiology of adjudicated TMA in consecutive KTR during the. 2009–2021 period. Results TMA was found in 77/1644 (4.7%) KTR. Early TMA (n = 24/77 (31.2%); 1.5% of all KTR) occurred during the first two weeks ((median, IQR) 3 [1–8] days). Triggers included acute antibody-mediated rejection (ABMR, n = 4) and bacterial infections (n = 6). Graft survival (GS) was 100% and recurrence rate (RR) was 8%. Unexpected TMA (n = 31/77 (40.2%); 1.5/1000 patient-years) occurred anytime during follow-up (3.0 (0.5–6.2) years). Triggers included infections (EBV/CMV: n = 10; bacterial: n = 6) and chronic active ABMR (n = 5). GS was 81% and RR was 16%. Graft-failure associated TMA (n = 22/77 (28.6%); 2.2% of graft losses) occurred after 8.8 (4.9–15.5) years). Triggers included acute (n = 4) or chronic active (n = 14) ABMR, infections (viral: n = 6; bacterial: n = 5) and cancer (n = 6). 15 patients underwent transplantectomy. RR was 27%. Atypical (n = 6) and typical (n = 2) haemolytic and uremic syndrome, and isolated CNI toxicity (n = 4) were rare. Two-third of biopsies presented TMA features. Conclusions TMA are mostly due to ABMR and infections; causes of TMA are frequently combined. Management often is heterogenous. Our nosology based on TMA timing identifies situations with distinct incidence, causes and prognosis.

Published
2023
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7. Effect of Bubbling on Ignition of PMMA Slab: Change in Thermo-Physical and Thermo-Radiative Properties

Author

Chloë Vincent, Claire Longuet, Laurent Aprin, Pierre Slangen, Guillaume Rambaud, and Laurent Ferry

Subjects
bubbling, PMMA, ignition, combustion, thermo-physical properties, thermo-radiative properties, Physics, QC1-999
Abstract

In semi-transparent polymers, ignition is not only dependent on conductive thermal transfer into the material but also on in-depth absorption of the radiation. The aim of this work was to investigate the influence of bubbling on the thermo-physical and thermo-radiative properties of PMMA and how it may affect its ignition. PMMA plates of varying thickness were exposed to the heat flux of two radiative sources with different emission spectra. Exposure was stopped after different periods of time to study bubbling kinetics and bubble size distribution by optical microscopy. Front and back surface temperatures of samples were recorded during heat exposure. The results indicate that the bubble size distribution is closely related to the temperature gradient within the sample. Steep thermal gradients lead to small-sized bubbles underneath the exposed surface, while weak thermal gradients generate a wider size distribution with in-depth bubbling. All thermo-physical quantities k, ρ and Cp were shown to decrease with increasing bubbling degree. Likewise, it was highlighted that bubbling modifies the thermo-radiative properties of PMMA, especially in the near-infrared range. Transmittance decreases while absorbance increases with a bubbling degree. The increase in the absorption coefficient was attributed to multiple scattering by bubbles that expand the pathway of radiation into the materials. It was concluded that changes in both the thermo-physical and thermo-radiative properties with bubbling were likely to account for the delay in ignition observed when using the near-infrared heating source.

Published
2024
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8. A One-Step Approach for a Durable and Highly Hydrophobic Coating for Flax Fabrics for Self-Cleaning Application

Author

Antoine Ishak, Rodolphe Sonnier, Belkacem Otazaghine, and Claire Longuet

Subjects
flax fabric, hydrophobisation, self-cleaning, PDMS, hydrosilylation, coating, Organic chemistry, QD241-441
Abstract

Highly hydrophobic flax fabrics with durable properties were prepared using the “dip-coating” method for self-cleaning application. Flax fabrics were coated with a polysiloxane coating via a hydrosilylation reaction with a Karstedt catalyst at room temperature. The coated fabrics displayed highly and durable hydrophobic properties (contact angle and sliding angle of about 145° and 23°, respectively) with good self-cleaning ability for certain pollutants and excellent durability. Moreover, the influence of the coating process on the mechanical properties of fabrics was investigated. A decrease in E modulus and an increase in tensile stress at maximum force and elongation at maximum force has been observed. Furthermore, this influence of the coating process can be easily controlled by adjusting the proportion of curing agent in the treatment solution.

Published
2024
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10. 40-tesla pulsed-field cryomagnet for single crystal neutron diffraction

Author

Duc, Fabienne, Tonon, Xavier, Billette, Julien, Rollet, Bertrand, Knafo, William, Bourdarot, Frédéric, Béard, Jérome, Mantegazza, Frédéric, Longuet, Benjamin, Lorenzo, Jose-Emilio, Lelièvre-Berna, Eddy, Frings, Paul, and Regnault, Louis-Pierre

Subjects
Physics - Instrumentation and Detectors, Condensed Matter - Strongly Correlated Electrons
Abstract

We present the first long-duration and high duty cycle 40-tesla pulsed-field cryomagnet addressed to single crystal neutron diffraction experiments at temperatures down to 2 K. The magnet produces a horizontal field in a bi-conical geometry, $\pm$15 and $\pm$30{\deg} upstream and downstream of the sample, respectively. Using a 1.15MJ mobile generator, magnetic field pulses of 100 ms length are generated in the magnet, with a rise time of 23 ms and a repetition rate of 6-7 pulses per hour at 40 T. The setup was validated for neutron diffraction on the CEA-CRG three-axis spectrometer IN22 at the ILL., Comment: 7 pages, 8 figures

Published
2018
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11. Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic

Author

Phimpha Paboriboune, Keokedthong Phongsavan, Phetsamone Arounlangsy, Bruno Flaissier, Oukham Aphayarath, Prasit Phimmasone, Ketmala Banchongphanith, Mixi Xayaovong, Gonzague Jourdain, Anne‐Marie Schott, Mitra Saadatian‐Elahi, Laurent Magaud, Amna Klich, Nicole Ngo‐Giang‐Huong, Isabelle Heard, Muriel Rabilloud, Valentina Sanchez Picot, and Christophe Longuet

Subjects
careHPV™, cervical cancer, HIV‐1, Lao PDR, liquid‐based cytology, Papanicolaou test, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background In the Lao People's Democratic Republic (Lao PDR), cervical cancer is the third leading cause of women cancer. Aims The objective of this cross‐sectional study was to compare the efficacy of careHPV™ test versus conventional Pap smear or Siriraj liquid‐based cytology in the detection of cervical cancer in women living with human immunodeficiency virus type 1 (HIV‐1). Materials & Methods Overall, 631 women consented to participate. Four cervical specimens were taken for the purpose of conventional Pap smear, Siriraj liquid‐based cytology, careHPV™ test, and HPV‐16 genotyping. The exact McNemar test was used to compare the efficacy and diagnostic performance of the tests. Results Of the 631 women with follow‐up, 331 were human papillomavirus (HPV) negative. High‐grade squamous intraepithelial lesions were found in 37 women, biopsy‐proven high‐grade cervical intraepithelial neoplasia in 50 women, and invasive carcinoma in seven women. The proportion of women with high‐grade cervical lesion or carcinoma detected after abnormal careHPV™ test was higher (6.02%; 95% confidence interval [CI]: 4.4–8.1) than that detected by conventional Pap smear (4.59%; 95% CI: 3.2–6.5). careHPV™ and HPV‐16 genotyping had, respectively, the highest sensitivity (80.8%; 95% CI: 67.4–89.5) and specificity (92.2%; 95% CI: 89.8–94.2). HPV‐16 was the most frequently detected genotype. Conclusions careHPV™ test represents a screening option in Lao PDR, particularly in women living with HIV‐1 because of higher prevalence of chronic HPV in this population.

Published
2022
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13. Outcomes of kidney‐transplanted patients with history of intestinal reconstruction of the urinary tract

Author

Juliette Gueguen, Marc‐Olivier Timsit, Anne Scemla, Jean‐Michel Boutin, Franck Bruyere, Hélène Longuet, Rebecca Sberro‐Soussan, Christophe Legendre, Dany Anglicheau, and Matthias Büchler

Subjects
kidney allograft survival, kidney failure, kidney transplantation, surgical complications, urinary tract deviation, urinary tract dysfunctions, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Due to increased risk of pyelonephritis, patients with intestinal reconstruction of the lower urinary tract (IRLUT) have long been advised against kidney transplantation. The aim of this study was to compare the outcomes of transplantation between patients with IRLUT and patients with normal LUT (NLUT) using propensity score matching method. Methods The study included 23 kidney recipients with IRLUT matched to 46 kidney recipients with NLUT using known allograft survival and pyelonephritis risk factors as covariates. One‐, 5‐, and 10‐year graft survival, pyelonephritis, and surgical complications occurrence and graft function were compared. Results One‐, 5‐, and 10‐year graft survival were 96%, 91%, and 63% in the IRLUT group and 96%, 88%, and 70% in the NLUT group, respectively (p = 0.72). Patients with IRLUT had increased cumulative risk of pyelonephritis at 10 years (70% vs. 19%; log‐rank

Published
2022
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16. Au sujet du « pluriel » : Une « didactique de la Relation » à la lumière de Jean-Luc Nancy (Être singulier pluriel, 1996).

Author

SPRINGER Claude and LONGUET Frédérique

Subjects
Ontology, plurilingualism, plural being, Relation, languaging, Autonomy, Special aspects of education, LC8-6691, Theory and practice of education, LB5-3640
Abstract

Following the publication of their last work on the “didactics of Relation”, the authors offer additional insight from the book by Jean-Luc Nancy, Être singulier pluriel. The aim of this article is to clarify the term “plural” which characterizes the didactics of “pluri”lingualism by extending it to the ontological question of “being plural”. The language-culture didactics is thus invited to make its “Copernican revolution” by explicitly subscribing to social approaches based on collaboration and reticulated mediations.

Published
2022
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17. Early changes in renal resistive index and mortality in diabetic and nondiabetic kidney transplant recipients: a cohort study

Author

Jean-Baptiste de Freminville, Louis-Marie Vernier, Jérome Roumy, Frédéric Patat, Philippe Gatault, Bénédicte Sautenet, Christelle Barbet, Hélène Longuet, Elodie Merieau, Matthias Buchler, and Jean-Michel Halimi

Subjects
Renal resistive index, Diabetes mellitus, Ultrasonography, Kidney transplantation, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Renal resistive index (RI) predicts mortality in renal transplant recipients (RTR). However, its predictive value may be different according to the time of measurement. We analysed RI changes between 1 month and 3 months after transplantation and its predictive value for death with a functioning graft (DWFG). Methods We conducted a retrospective study in 1685 RTR between 1985 and 2017. The long-term predictive value of changes in RI value from 1 month to 3 months was assessed in diabetic and non-diabetic RTR. Results Best survival was observed in RTR with RI

Published
2021
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19. Consciousness and the Physical World

Author

Josephson, B. D., Ramachandran, V. S., Dyson, F. J., Vesey, G., Gregory, R. L., Longuet-Higgins, H. C., Humphrey, N. K., Barlow, H. B., MacKay, D. M., Roth, M., and Padfield, S.

Subjects
Physics - General Physics, Physics - History and Philosophy of Physics
Abstract

Edited proceedings of an interdisciplinary symposium on consciousness held at the University of Cambridge in January 1978. The purpose of the Cambridge conference was to encourage distinguished scientists to express their views on the relationship of conscious experience to the physical world., Comment: The text was prepared using OCR software, and in consequence some errors are present. An error-free version obtained by scanning can be found at https://www.repository.cam.ac.uk/handle/1810/245189

Published
2014

20. Bacterial and viral co-infections in patients with severe SARS-CoV-2 pneumonia admitted to a French ICU

Author

Damien Contou, Aurore Claudinon, Olivier Pajot, Maïté Micaëlo, Pascale Longuet Flandre, Marie Dubert, Radj Cally, Elsa Logre, Megan Fraissé, Hervé Mentec, and Gaëtan Plantefève

Subjects
COVID-19, SARS-CoV-2, Bacteria, Co-infection, Staphylococcus aureus, Streptococcus pneumoniae, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Data on the prevalence of bacterial and viral co-infections among patients admitted to the ICU for acute respiratory failure related to SARS-CoV-2 pneumonia are lacking. We aimed to assess the rate of bacterial and viral co-infections, as well as to report the most common micro-organisms involved in patients admitted to the ICU for severe SARS-CoV-2 pneumonia. Patients and methods In this monocenter retrospective study, we reviewed all the respiratory microbiological investigations performed within the first 48 h of ICU admission of COVID-19 patients (RT-PCR positive for SARS-CoV-2) admitted for acute respiratory failure. Results From March 13th to April 16th 2020, a total of 92 adult patients (median age: 61 years, 1st–3rd quartiles [55–70]; males: n = 73/92, 79%; baseline SOFA: 4 [3–7] and SAPS II: 31 [21–40]; invasive mechanical ventilation: n = 83/92, 90%; ICU mortality: n = 45/92, 49%) were admitted to our 40-bed ICU for acute respiratory failure due to SARS-CoV-2 pneumonia. Among them, 26 (28%) were considered as co-infected with a pathogenic bacterium at ICU admission with no co-infection related to atypical bacteria or viruses. The distribution of the 32 bacteria isolated from culture and/or respiratory PCRs was as follows: methicillin-sensitive Staphylococcus aureus (n = 10/32, 31%), Haemophilus influenzae (n = 7/32, 22%), Streptococcus pneumoniae (n = 6/32, 19%), Enterobacteriaceae (n = 5/32, 16%), Pseudomonas aeruginosa (n = 2/32, 6%), Moraxella catarrhalis (n = 1/32, 3%) and Acinetobacter baumannii (n = 1/32, 3%). Among the 24 pathogenic bacteria isolated from culture, 2 (8%) and 5 (21%) were resistant to 3rd generation cephalosporin and to amoxicillin–clavulanate combination, respectively. Conclusions We report on a 28% rate of bacterial co-infection at ICU admission of patients with severe SARSCoV-2 pneumonia, mostly related to Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae and Enterobacteriaceae. In French patients with confirmed severe SARSCoV-2 pneumonia requiring ICU admission, our results encourage the systematic administration of an empiric antibiotic monotherapy with a 3rd generation cephalosporin, with a prompt de-escalation as soon as possible. Further larger studies are needed to assess the real prevalence and the predictors of co-infection together with its prognostic impact on critically ill patients with severe SARS-CoV-2 pneumonia.

Published
2020
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21. Make science evolve into a One Health approach to improve health and security: a white paper

Author

Albert D. M. E. Osterhaus, Chris Vanlangendonck, Maurizio Barbeschi, Christianne J. M. Bruschke, Renee Christensen, Peter Daszak, Frouke de Groot, Peter Doherty, Patrick Drury, Sabri Gmacz, Keith Hamilton, John Hart, Rebecca Katz, Christophe Longuet, Jesse McLeay, Gaetano Morelli, Joergen Schlundt, Trevor Smith, Sameera Suri, Khristeen Umali, Jan van Aken, and Jaap A. Wagenaar

Subjects
Environmental sciences, GE1-350, Public aspects of medicine, RA1-1270
Abstract

Abstract The World One Health Congresses are biennial gatherings of approximately 1500 professionals from relevant international organisations, OIE, FAO, WHO, World Bank, leading scientific experts and researchers in the field of One Health, animal production and trade, food safety, animal health, human health and environmentology/ecology, government representatives in public health, human health, food safety, environmental health and global health security. The Congress is organized by the One Health Platform. This white paper summarizes highlights of the 5th International One Health Congress in Saskatoon, Canada, June 2018 and serves as a roadmap for the future, detailing several concrete action points to be carried out in the run-up to the 6th World One Health Congress in Edinburgh, Scotland, June 2020.

Published
2020
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24. Exploration of fruit parameters for non-destructive identification of calyx cavity in ‘Fuyu’ persimmon (Diospyros kakiL.)

Author

Longuet-Higgins, Josephine M., Rivera, Sebastian A., Woolf, Allan B., and Li, Mo

Abstract

ABSTRACTCalyx cavity is a common physiological disorder in many persimmon cultivars. It is characterised by a separation between the calyx and the surrounding flesh. The presence of calyx cavity in export fruit can lead to phytosanitary risks and reduced storage potential due to more rapid softening and increased chilling injury. Manual detection of calyx cavity at packing is very time-consuming and uneconomic. This work investigated the ability of non-destructive evaluation, combined with modelling, to identify calyx cavity in ‘Fuyu’ persimmons. Fruit were evaluated at harvest, followed by a period of nine-week storage in modified atmosphere packaging at 0°C. The presence and severity of calyx cavity was related with higher red colouration and fresh weight before storage. Using colour index data and weight data, binary classification of calyx cavity by linear discriminant analysis (LDA) resulted 74.1% correct segregation. The model correctly identified 70.5% of calyx cavity fruit (29.5% false negatives) and 77.4% of no cavity fruit (22.6% false positives). The use of non-destructive calyx cavity classification based on the evaluation of quality parameters is a starting point in providing the ability to segregate healthy fruit before packaging and storage. Further work is necessary to improve model performance before implementation is viable.

Published
2024
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27. Place du pharmacien d'officine en soins palliatifs.

Author

Longuet, Vinciane

Abstract

Copyright of Actualités Pharmaceutiques is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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28. Sex differences in mandibular repositioning device therapy effectiveness in patients with obstructive sleep apnea syndrome

Author

Vecchierini, Marie-Françoise, Attali, Valérie, Collet, Jean-Marc, d’Ortho, Marie-Pia, Goutorbe, Frederic, Kerbrat, Jean-Baptiste, Leger, Damien, Lavergne, Florent, Monaca, Christelle, Monteyrol, Pierre-Jean, Morin, Laurent, Mullens, Eric, Pigearias, Bernard, Martin, Francis, Khemliche, Hauria, Lerousseau, Lionel, Meurice, Jean-Claude, on behalf of the ORCADES investigators, Abedipour, Darius, Allard-Redon, Aurélie, Aranda, Alexandre, Attali, Valérie, Bavozet, Frédérique, Becu, Martine, Beruben, Wally, Bessard, Jerome, Bonafe, Isabelle, Boukhana, Mohammed, Chabrol, Bruno, Chatte, Gérard, Lebret, Chauvel, Collet, Jean-Marc, Coste, Olivier, Dumont, Nathalie, Durand-Amat, Sophie, D’ortho, Marie-Pia, Elbaum, Jean Marc, De Santerre, Olivier Gallet, Goutorbes, Frédéric, Grandjean, Thierry, Guyot, Wilma, Hammer, Doniphan, Havasi, Carmen, Huet, Pascal, Kerbrat, Jean Baptiste, Khemliche, Hauria, Koltes, Christian, Leger, Damien, Lacassagne, Laurent, Laur, Xavier, Lerousseau, Lionel, Liard, Olivier, Loisel, Christophe, Longuet, Matthieu, Mallart, Anne, Martin, Francis, Merle Beral, Frédéric, Meurice, Jean Claude, Mokhtari, Zoubida, Monaca, Christelle, Monteyrol, Pierre Jean, Muir, Jean-François, Mullens, Eric, Muller, Dominique, Paoli, Charles, Petit, François Xavier, Pigearias, Bernard, Pradines, Marc, Prigent, Arnauld, Putterman, Gil, Rey, Marc, Samama, Mickael, Tamisier, Renaud, Tiberge, Michel, Tison, Cyrille, Tordjman, Fabienne, Triolet, Bernard, Vacher, Christian, Vecchierini, Marie-Françoise, and Verain, Alain

Published
2019
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29. “You helped me keep my head above water”—experience of bereavement research after loss of a loved one in the ICU: insights from the ARREVE study

Author

Laurent, Alexandra, Reignier, Jean, Le Gouge, Amélie, Cottereau, Alice, Adda, Mélanie, Annane, Djillali, Audibert, Juliette, Barbier, François, Bardou, Patrick, Bourcier, Simon, Bourenne, Jeremy, Boyer, Alexandre, Brenas, François, Das, Vincent, Desachy, Arnaud, Devaquet, Jérôme, Feissel, Marc, Ganster, Frédérique, Garrouste-Orgeas, Maïté, Grillet, Guillaume, Guisset, Olivier, Hamidfar-Roy, Rebecca, Hyacinthe, Anne-Claire, Jochmans, Sebastien, Jourdain, Mercé, Lautrette, Alexandre, Lerolle, Nicolas, Lesieur, Olivier, Lion, Fabien, Mateu, Philippe, Megarbane, Bruno, Merceron, Sybille, Mercier, Emmanuelle, Messika, Jonathan, Morin-Longuet, Paul, Philippon-Jouve, Bénédicte, Quenot, Jean-Pierre, Renault, Anne, Repesse, Xavier, Rigaud, Jean-Philippe, Robin, Ségolène, Roquilly, Antoine, Seguin, Amélie, Thevenin, Didier, Tirot, Patrice, Vinatier, Isabelle, Azoulay, Elie, Robert, René, and Kentish-Barnes, Nancy

Published
2019
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30. Protocol for the DisCoVeRy trial: multicentre, adaptive, randomised trial of the safety and efficacy of treatments for COVID-19 in hospitalised adults

Author

Florence Ader, François-Xavier Lescure, Laetitia Moinot, Christelle Delmas, Hélène Espérou, Laurent Abel, Benjamin Leveau, Vinca Icard, Toni Alfaiate, Charles Burdet, France Mentré, Marion Schneider, Nathan Peiffer-Smadja, Julien Poissy, Lila Bouadma, Bruno Lina, Florence Morfin-Sherpa, Maude Bouscambert, Alexandre Gaymard, Gilles Peytavin, Jeremie Guedj, Cedric Laouenan, Drifa Belhadi, Axelle Dupont, Basma Basli, Anissa Chair, Samira Laribi, Julie Level, Marie-Capucine Tellier, Aline Dechanet, Dominique Costagliola, Sandrine Couffin-Cadiergues, Juliette Saillard, Claire Fougerou, Carole Cagnot, Soizic Le Mestre, Delphine Lebrasseur-Longuet, Ventzislava Petrov-Sanchez, Alpha Diallo, NoéMie Mercier, Sarah Tubiana, Benjamin Hamze, Ambre Gelley, Marion Noret, Eric D’Ortenzio, Oriane Puechal, and Caroline Semaille

Subjects
Medicine
Published
2020
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31. A study to better understand under-utilization of laboratory tests for antenatal care in Senegal.

Author

Anna Helena Van't Hoog, Aicha Sarr, Winny Koster, Louis Delorme, Souleymane Diallo, Jean Sakande, Constance Schultsz, Christophe Longuet, Ahmad Iyane Sow, and Pascale Ondoa

Subjects
Medicine, Science
Abstract

OBJECTIVE:To better understand factors contributing to underutilization of laboratory services for health care delivery in sub-Saharan Africa, we conducted a study in Senegalese Antenatal Care clinics (ANC) and laboratories to determine the extent of underutilization, contributing factors, and bottlenecks in the cascade of care from first ANC visit, test uptake, to availability of test results and appropriate clinical management. METHODS:At 16 health facilities, pregnant women attending for their first ANC visit were consecutively recruited and information was prospectively collected on the request, execution, results and clinical management of seven nationally recommended laboratory screening tests for normal pregnancy: hemoglobin concentration (Hb), syphilis serology, HIV serology, determination of proteinuria (PU), determination of blood group and Rhesus factor, Emmel test to detect sickle cell disease, and glycaemia. Health facility staff were interviewed on human resource capacity, management of the ANC and the laboratory, and availability and use of guidelines. RESULTS:Of 1246 ANC attendants, 400 (32%) had complete results. Completeness varied between facilities from 0-99%. In multilevel logistic regression analysis of women nested in facilities, complete uptake was lower if women started ANC later in pregnancy; very low in rural ANC attendants who ever delivered compared to urban primigravidae (OR 0.064; 95%CI 0.00-0.52); and higher if the facility routinely recommended all seven tests. In the cascade from test request to clinical management, the most frequent bottleneck was non-execution of requested tests, while unavailability of results for executed test was uncommon (

Published
2020
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33. Make science evolve into a One Health approach to improve health and security: a white paper

Author

Osterhaus, Albert D. M. E., Vanlangendonck, Chris, Barbeschi, Maurizio, Bruschke, Christianne J. M., Christensen, Renee, Daszak, Peter, de Groot, Frouke, Doherty, Peter, Drury, Patrick, Gmacz, Sabri, Hamilton, Keith, Hart, John, Katz, Rebecca, Longuet, Christophe, McLeay, Jesse, Morelli, Gaetano, Schlundt, Joergen, Smith, Trevor, Suri, Sameera, Umali, Khristeen, van Aken, Jan, and Wagenaar, Jaap A.

Published
2020
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34. Evaluation of Optical and Acoustical Properties of Ba1−xSrxTiO3 Thin Film Material Library via Conjugation of Picosecond Laser Ultrasonics with X-ray Diffraction, Energy Dispersive Spectroscopy, Electron Probe Micro Analysis, Scanning Electron and Atomic Force Microscopies

Author

Sathyan Sandeep, Samuel Raetz, Jerome Wolfman, Beatrice Negulescu, Guozhen Liu, Jean-Louis Longuet, Théo Thréard, and Vitalyi E. Gusev

Subjects
picosecond laser ultrasonics, time-domain Brillouin scattering, optoacoustics, acousto-optics, nanoascale imaging, nanomaterials, Chemistry, QD1-999
Abstract

Wide-range continuous spatial variation of the film composition in lateral compositionally graded epitaxial films requires the development of high throughput measurement techniques for their local and non-destructive characterization with the highest possible spatial resolution. Here we report on the first application of the picosecond laser ultrasonics (PLU) technique for the evaluation of acoustical and optical parameters of lateral compositionally graded film, the Ba1−xSrxTiO3 (0 ≤ x ≤ 1) material library. The film was not dedicatedly prepared for its opto-acousto-optic evaluation by PLU, exhibiting significant lateral variations in thickness and surface roughness. Therefore, the achieved measurements of the sound velocity and of the optical refractive index, and characterization of the surface roughness confirm the robustness of the PLU technique for thin film evaluation. We hope that the first measurements of the acoustical and optical properties of epitaxial grown Ba1−xSrxTiO3 (0 ≤ x ≤ 1) by PLU technique accomplished here provide the parameters required for more extended predictive design of the phononic, photonic and phoxonic mirrors and cavities with superior properties/functionalities for novel multifunctional nanodevices.

Published
2021
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35. Antibody Responses after a Third Dose of COVID-19 Vaccine in Kidney Transplant Recipients and Patients Treated for Chronic Lymphocytic Leukemia

Author

Julien Marlet, Philippe Gatault, Zoha Maakaroun, Hélène Longuet, Karl Stefic, Lynda Handala, Sébastien Eymieux, Emmanuel Gyan, Caroline Dartigeas, and Catherine Gaudy-Graffin

Subjects
COVID-19, vaccine, kidney transplant, chronic lymphocytic leukemia, antibody, Medicine
Abstract

The impact of a third dose of COVID-19 vaccine on antibody responses is unclear in immunocompromised patients. The objective of this retrospective study was to characterize antibody responses induced by a third dose of mRNA COVID-19 vaccine in 160 kidney transplant recipients and 20 patients treated for chronic lymphocytic leukemia (CLL). Prevalence of anti-spike IgG ≥ 7.1 and ≥ 30 BAU/mL after the third dose were 47% (75/160) and 39% (63/160) in kidney transplant recipients, and 57% (29/51) and 50% (10/20) in patients treated for CLL. Longitudinal follow-up identified a moderate increase in SARS-CoV-2 anti-spike IgG levels after a third dose of vaccine in kidney transplant recipients (0.19 vs. 5.28 BAU/mL, p = 0.03) and in patients treated for CLL (0.63 vs. 10.7 BAU/mL, p = 0.0002). This increase in IgG levels had a limited impact on prevalence of anti-spike IgG ≥ 30 BAU/mL in kidney transplant recipients (17%, 2/12 vs. 33%, 4/12, p = 0.64) and in patients treated for CLL (5%, 1/20 vs. 45%, 9/20, p = 0.008). These results highlight the need for vaccination of the general population and the importance of non-medical preventive measures to protect immunocompromised patients.

Published
2021
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36. Cationic Polymerization of Hexamethylcyclotrisiloxane in Excess Water

Author

Quentin Barnes, Claire Longuet, and François Ganachaud

Subjects
Piers-Rubinsztajn catalyst, surfactant-free polymerization, polydimethylsiloxane, Organic chemistry, QD241-441
Abstract

Ring-opening ionic polymerization of cyclosiloxanes in dispersed media has long been discovered, and is nowadays both fundamentally studied and practically used. In this short communication, we show some preliminary results on the cationic ring-opening polymerization of hexamethylcyclotrisiloxane (D3), a crystalline strained cycle, in water. Depending on the catalyst or/and surfactants used, polymers of various molar masses are prepared in a straightforward way. Emphasis is given here on experiments conducted with tris(pentafluorophenyl)borane (BCF), where high-molar polymers were generated at room temperature. In surfactant-free conditions, µm-sized droplets are stabilized by silanol end-groups of thus generated amphiphilic polymers, the latter of which precipitate in the course of reaction through chain extension. Introducing various surfactants in the recipe allows generating smaller emulsions in size with close polymerization ability, but better final colloidal stability, at the expense of low small cycles’ content. A tentative mechanism is finally proposed.

Published
2021
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39. Influence of Density on Foam Collapse under Burning

Author

Abdoul Fayçal Baguian, Salifou Koucka Ouiminga, Claire Longuet, Anne-Sophie Caro-Bretelle, Stéphane Corn, Antoine Bere, and Rodolphe Sonnier

Subjects
polyurethane foam, fire behaviour, collapse, Organic chemistry, QD241-441
Abstract

The fire behaviour of flexible polyurethane foams was studied using a cone calorimeter, with a special emphasis on the collapse step. Only one peak of heat release rate, ranging from 200 to 450 kW/m2, is observed for thin foams, depending on the foam density and the heat flux. On the contrary, heat release rate (HRR) curves exhibit two peaks for 10 cm-thick foams, the second one corresponding to the pool fire formed after foam collapse. In all cases, the collapse occurs at a constant rate through the whole thickness. The rate of the recession of the front was calculated using digital and infrared cameras. Interestingly, its value is relatively constant whatever the heat flux (especially between 25 and 35 kW/m2), probably because of the very low heat conductivity preventing heat transfer through the thickness. The rate increases for the lightest foam but the fraction of burnt polymer during collapse is constant. Therefore, the pool fire is more intense for the densest foam. A simple macroscopic model taking into account only the heat transfer into the foam leads to much lower front recession rates, evidencing that the collapse is piloted by the cell walls’ rigidity.

Published
2020
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44. Antibiotic prescription behaviours in Lao People's Democratic Republic: a knowledge, attitude and practice survey

Author

Fabrice Quet, Erika Vlieghe, Caroline Leyer, Yves Buisson, Paul N Newton, Philaysak Naphayvong, Valy Keoluangkhot, Monique Chomarat, Christophe Longuet, Nicolas Steenkeste, and Jan Jacobs

Subjects
Public aspects of medicine, RA1-1270
Abstract

Objective To assess the antibiotic prescribing practices of doctors working in the Lao People's Democratic Republic and their knowledge of local antibiotic resistance patterns. Methods Doctors attending morning meetings in 25 public hospitals in four provinces were asked to complete a knowledge, attitude and practice survey. The questionnaire contained 43 multiple choice questions that the doctor answered at the time of the meeting. Findings The response rate was 83.4% (386/463). Two hundred and seventy doctors (59.8%) declared that they had insufficient information about antibiotics. Only 14.0% (54/386) recognized the possibility of cephalosporin cross-resistance in methicillin-resistant Staphylococcus aureus. Most participants had no information about local antibiotic resistance for Salmonella Typhi (211/385, 54.8%) and hospital-acquired pneumonia (253/384, 65.9%). Unnecessary antibiotic prescriptions were considered as harmless by 115 participants and 148 considered locally-available generic antibiotics to be of poor quality. Nearly three-quarters (280/386) of participants agreed that it was difficult to select the correct antibiotics. Most participants (373/386) welcomed educational programmes on antibiotic prescribing and 65.0% (249/383) preferred local over international antibiotic guidelines. Conclusion Doctors in the Lao People's Democratic Republic seem to favour antibiotic prescribing interventions. Health authorities should consider a capacity building programme that incorporates antibiotic prescribing and hospital infection control.

Published
2015
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46. Former les enseignants de français par l’activité de création numérique dialoguée

Author

Frédérique Longuet

Subjects
formation professionnelle, web 2.0, créativité, compétence, Language and Literature, Romanic languages, PC1-5498
Abstract

L’objectif de cet article consiste à montrer qu’il est possible et souhaitable d’organiser une approche «actionnelle» de la formation des enseignants de Français Langue Étrangère. Notre réflexion s’appuie sur une expérimentation auprès d’étudiants du master Enseignement-Éducation-Médiation 1er degré (IUFM Paris Sorbonne). Après un rapide rappel de l’optique institutionnelle en formation initiale (autour de l’approche par tâche scolaire), nous présenterons le construit théorique qui sous-tend l’approche alternative que nous proposons. Nous verrons, à partir de quelques extraits de corpus, comment les étudiants construisent ensemble de nouvelles compétences professionnelles. Nous présenterons aussi les effets produits sur les élèves. Cette approche se situe dans la perspective d’une éducation plurilingue et interculturelle qui s’ouvre sur la nécessité de prendre en compte le développement de la personne et de l’acteur social pour une meilleure citoyenneté.

Published
2014

48. ICU physicians’ and nurses’ perceptions of terminal extubation and terminal weaning: a self-questionnaire study

Author

Cottereau, Alice, Robert, René, le Gouge, Amélie, Adda, Mélanie, Audibert, Juliette, Barbier, François, Bardou, Patrick, Bourcier, Simon, Boyer, Alexandre, Brenas, François, Canet, Emmanuel, Da Silva, Daniel, Das, Vincent, Desachy, Arnaud, Devaquet, Jérôme, Embriaco, Nathalie, Eon, Beatrice, Feissel, Marc, Friedman, Diane, Ganster, Frédérique, Garrouste-Orgeas, Maïté, Grillet, Guillaume, Guisset, Olivier, Guitton, Christophe, Hamidfar-Roy, Rebecca, Hyacinthe, Anne-Claire, Jochmans, Sebastien, Lion, Fabien, Jourdain, Mercé, Lautrette, Alexandre, Lerolle, Nicolas, Lesieur, Olivier, Mateu, Philippe, Megarbane, Bruno, Mercier, Emmanuelle, Messika, Jonathan, Morin-Longuet, Paul, Philippon-Jouve, Bénédicte, Quenot, Jean-Pierre, Renault, Anne, Repesse, Xavier, Rigaud, Jean-Philippe, Robin, Ségolène, Roquilly, Antoine, Seguin, Amélie, Thevenin, Didier, Tirot, Patrice, Contentin, Laetitia, Kentish-Barnes, Nancy, and Reignier, Jean

Published
2016
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50. Emotion, Intent and Voluntary Movement in Children with Autism. an Example: The Goal Directed Locomotion

Author

Longuet, Sophie, Ferrel-Chapus, Carole, and Oreve, Marie-Joelle

Abstract

This article focuses on the impact of intentionality on goal directed locomotion in healthy and autistic children. Closely linked with emotions and motivation, it is directly connected with movement planning. Is planning only preserved when the goal of the action appears motivating for healthy and autistic children? Is movement programming similar for autistic and healthy children, and does it vary according to the emotional valence of the object? Moving in a straight line, twenty autistic and healthy children had to retrieve a positive or aversive emotional valence object. The results suggest planning and programming are preserved in an emotionally positive situation. However, in an aversive situation, autistic children appear to have a deficit in terms of planning and sometimes programming.

Published
2012
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