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6 results on '"Longo, FJL"'

1. LAUDES Study: impact of digital ulcers on hand functional limitation, work productivity and daily activities, in systemic sclerosis patients

Author

Castellvi, I, Eguiluz, S, Escudero-Contreras, A, Rios, JJ, Calvo-Alen, J, Callejas-Rubio, JL, De la Puente, C, Simeon, CP, Narvaez, FJ, Espinosa, G, Carreira, PE, Rubio-Rivas, M, Alegre, JJ, Roman-Ivorra, JA, Fonollosa, V, de la Iglesia, BA, Ajo, JB, Perdomo, DB, Catalan, EB, Otano, JB, Rodriguez, JSB, Freire, MC, Alutiz, C, Montes, IC, Lecumberri, MC, Monsalvo, RD, Alvarez, ED, Dubuc, CAE, Arberas, MVE, Mateo, PF, Dapena, FDF, Gonzalez, MF, Aparicio, AG, Hernandez, FJG, de Salazar, JG, Nieto, JAG, Gil, JG, Guillen-Del-Castillo, A, Hidalgo, JI, Mas, TJ, Pineiro, MCL, Longo, FJL, Nunez, LML, Ballve, AM, Fernandez-Cid, CM, Miguelez, R, Rodriguez, MAM, Morales, JM, Morla, RM, Bruno, SO, Marques, AO, Laraundogoitia, EO, Ortego, N, Santamaria, VO, Conesa, MPP, Sandoval, TP, Simon, AP, Lozano, BR, Cid, AR, Comet, LS, Osorio, JS, Lopez, AS, Soler, GS, Guevara, MS, Parra, JAT, Ramos, CT, Beltran, JT, Montanez, JMU, and Rabaneda, EV

Subjects
Quality of life, Scleroderma and related disorders, Disability evaluation, Human activities, Hand
Abstract

The objective of this study was to evaluate the impact of digital ulcers (DUs) in daily life of systemic sclerosis (SSc) Spanish patients. We developed a multicenter observational study to compare functional disability in SSc patients with active DUs vs. those without DUs. An additional correlation between perception of patients and physicians on disability due to DUs was performed. A total of 199 patients were enrolled, 70 (35%) with DUs. Patients with DUs were younger (48 vs. 58 years; p < 0.001) and had more frequently the diffuse subtype of SSc (45 vs. 24%; p = 0.004) than patients without DUs. Patients with DUs showed significantly higher scores in the Cochin Hand Function Scale overall (p < 0.002) and for each of its five dimensions. They also showed higher scores in the Systemic Sclerosis Health Assessment Questionnaire items related to hand function such as, dress and self-care (p < 0.013), eat (p < 0.013) and grip (p < 0.03), and higher Visual Analogic Scale scores for pain (p < 0.013), trouble related with Raynaud's Phenomenon (p < 0.001) and sense of severity (p < 0.004). Impact on daily activities was significantly higher in patients with DUs (p = 0.002), with a non-significant trend to experience higher impact on work productivity (p = 0.07). A high correlation was found between DUs patients and physicians opinion on the impact of DUs (daily life: Pearson R = 0.86; work productivity: Pearson R = 0.87). Study findings show an impaired hand function and increased disability for daily life activities and work productivity in SSc patients with DUs compared with patients without DUs in Spanish population.

Published
2019

2. NAILFOLD CAPILLAROSCOPY IN ANTISYNTHETASE SYNDROME (NASCAR): RESULTS OF A MULTICENTER, INTERNATIONAL STUDY OF THE AMERICAN AND EUROPEAN NETWORK OF ANTISYNTHETASE SYNDROME (AENEAS)

Author

Sebastiani, M, Triantafyllias, K, Manfredi, A, Gonzalez-Gay, Ma, Palmou-Fontana, N, Cassone, G, Drott, U, Delbruck, C, Rojas-Serrano, J, Bertolazzi, C, Nuno, L, Giannini, M, Iannone, F, Vicente, Ef, Castaneda, S, Selva-O'Callaghan, A, Araguas, Et, Emmi, G, Iuliano, A, Bauhammer, J, Miehle, N, Parisi, S, Cavagna, L, Codullo, V, Montecucco, Cm, Longo, Fjl, Martinez-Barrio, J, Nieto-Gonzalez, Jc, Vichi, S, Confalonieri, M, Bergner, R, Sulli, A, Bonella, F, Furini, F, Scire, Ca, Specker, C, Barsotti, S, Neri, R, Weinmann-Menke, J, Schwarting, A, Smith, V, and Cutolo, M

Published
2018

3. Mycobacterial Infection in Systemic Lupus Erythematosus: Clinical Significance and Associated Factors. Data from the Registry of Patients with SLE of the Spanish Society of Rheumatology (RELESSER)

Author

Lois-Iglesias, A, del Campo-Perez, V, Rua-Figueroa, I, Mourino-Rodriguez, C, Longo, FJL, Galindo, M, Calvo-Alen, J, Ruan, JI, Olive, A, Gonzalez, RBM, Fernandez-Nebro, A, Bernal, JA, Erausquin, C, Tomero, E, Horcada, ML, Uriarte, E, Freire, M, Montilla-Morales, CA, Atrio, AS, Boteanu, A, Alvarez, ED, Narvaez, J, Taboada, VM, Fernandez, LS, Lucea, ER, Andreu, JL, Beirain, JH, Gantes, M, Hernandez-Cruz, B, Venegas, JJP, Espanol, AP, Lozano-Rivas, N, Barcelo, MI, Bonilla, G, Torrente, V, Castellvi, I, Alegre, JJ, Moreno, M, de la Fuente, JLM, Magro-Checa, C, Rodriguez, TV, Quevedo, V, Richi, P, Sanchez, MTO, and Pego-Reigosa, JM

Published
2017

6. Clinical Spectrum Time Course in Anti Jo-1 Positive Antisynthetase Syndrome: Results From an International Retrospective Multicenter Study.

Author

Cavagna L, Nuño L, Scirè CA, Govoni M, Longo FJL, Franceschini F, Neri R, Castañeda S, Giraldo WAS, Caporali R, Iannone F, Fusaro E, Paolazzi G, Pellerito R, Schwarting A, Saketkoo LA, Ortego-Centeno N, Quartuccio L, Bartoloni E, Specker C, Murcia TP, La Corte R, Furini F, Foschi V, Corral JB, Airò P, Cavazzana I, Martínez-Barrio J, Hinojosa M, Giannini M, Barsotti S, Menke J, Triantafyllias K, Vitetta R, Russo A, Bajocchi G, Bravi E, Barausse G, Bortolotti R, Selmi C, Parisi S, Montecucco C, and González-Gay MA

Subjects
Adult, Aged, Antibodies, Antinuclear analysis, Arthritis immunology, Female, Humans, Male, Middle Aged, Myositis diagnosis, Retrospective Studies, Antibodies, Antinuclear immunology, Myositis immunology
Abstract

Anti Jo-1 antibodies are the main markers of the antisynthetase syndrome (ASSD), an autoimmune disease clinically characterized by the occurrence of arthritis, myositis, and interstitial lung disease (ILD). These manifestations usually co-occur (for practical purpose complete forms) in the same patient, but cases with only 1 or 2 of these findings (for practical purpose incomplete forms) have been described. In incomplete forms, the ex novo occurrence of further manifestations is possible, although with frequencies and timing not still defined. The aim of this international, multicenter, retrospective study was to characterize the clinical time course of anti Jo-1 positive ASSD in a large cohort of patients. Included patients should be anti Jo-1 positive and with at least 1 feature between arthritis, myositis, and ILD. We evaluated the differences between complete and incomplete forms, timing of clinical picture appearance and analyzed factors predicting the appearance of further manifestations in incomplete ASSD. Finally, we collected 225 patients (58 males and 167 females) with a median follow-up of 80 months. At the onset, complete ASSD were 44 and incomplete 181. Patients with incomplete ASSD had frequently only 1 of the classic triad findings (110 cases), in particular, isolated arthritis in 54 cases, isolated myositis in 28 cases, and isolated ILD in 28 cases. At the end of follow-up, complete ASSD were 113, incomplete 112. Only 5 patients had an isolated arthritis, only 5 an isolated myositis, and 15 an isolated ILD. During the follow-up, 108 patients with incomplete forms developed further manifestations. Single main feature onset was the main risk factor for the ex novo appearance of further manifestation. ILD was the prevalent ex novo manifestation (74 cases). In conclusion, ASSD is a condition that should be carefully considered in all patients presenting with arthritis, myositis, and ILD, even when isolated. The ex novo appearance of further manifestations in patients with incomplete forms is common, thus indicating the need for an adequate clinical and instrumental follow-up. Furthermore, the study clearly suggested that in ASSD multidisciplinary approach involving Rheumatology, Neurology, Pneumology, and Internal Medicine specialists is mandatory.

Published
2015
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