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1. Teacher Training for Social Sciences Education and a Democratic Citizenship in a Post-Conflict Society. The Case of the Basque Country

Author

Aritza Sáenz del Castillo Velasco, Joseba Iñaki Arregi-Orue, Leire Agirreazkuenaga Onaidia, and Joseba Jon Longarte Arriola

Abstract

Purpose: The Basque Country has been suffering political conflict and human rights´ violation for decades, tearing the social fabric. Human rights and peace education carried out through the testimony of the victims and their memory about this recent violent past can play an essential role in reestablishing the social understanding. This article aims to make known the experience of Adi-Adian initiative developed with the victims of the politic violence in the Teacher Training School of the University of Basque Country and asses its effectiveness in terms of critical thinking and empathy. Design/methodology/approach: This research is based on group discussion and personal surveys focused on students' feedback as a suitable method to analyze the way of thinking of students, their feelings and opinions about the violence. Findings: The results indicate that these initiatives implemented at school might be suitable to achieve the goals of human rights and peace education and deepen on democratic citizenship.

Published
2023

2. The PP2A regulator IER5L supports prostate cancer progression

Author

Jana R. Crespo, Natalia Martín-Martín, Saioa Garcia-Longarte, Jon Corres-Mendizabal, Onintza Carlevaris, Ianire Astobiza, Amaia Zabala-Letona, Marc Guiu, Mikel Azkargorta, Monika Gonzalez-Lopez, Nuria Macías-Cámara, Phuong Doan, Félix Elortza, Isabel Mendizabal, Jukka Westermack, Roger R. Gomis, Amaia Ercilla, and Arkaitz Carracedo

Subjects
Cytology, QH573-671
Abstract

Abstract Prostate cancer exhibits high prevalence and accounts for a high number of cancer-related deaths. The discovery and characterization of molecular determinants of aggressive prostate cancer represents an active area of research. The Immediate Early Response (IER) family of genes, which regulate Protein Phosphatase 2A (PP2A) activity, has emerged among the factors that influence cancer biology. Here, we show that the less studied member of this family, Immediate Early Response 5 like (IER5L), is upregulated in aggressive prostate cancer. Interestingly, the upregulation of IER5L expression exhibits a robust association with metastatic disease in prostate and is recapitulated in other cancer types. In line with this observation, IER5L silencing reduces foci formation, migration and invasion ability in a variety of human and murine prostate cancer cell lines. In vivo, using zebrafish and immunocompromised mouse models, we demonstrate that IER5L-silencing reduces prostate cancer tumor growth, dissemination, and metastasis. Mechanistically, we characterize the transcriptomic and proteomic landscapes of IER5L-silenced cells. This approach allowed us to identify DNA replication and monomeric G protein regulators as downstream programs of IER5L through a pathway that is consistent with the regulation of PP2A. In sum, we report the alteration of IER5L in prostate cancer and beyond and provide biological and molecular evidence of its contribution to tumor aggressiveness.

Published
2024
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3. METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Author

García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D’Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizabal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023
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4. METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Author

Raquel García-Vílchez, Ana M. Añazco-Guenkova, Sabine Dietmann, Judith López, Virginia Morón-Calvente, Silvia D’Ambrosi, Paz Nombela, Kepa Zamacola, Isabel Mendizabal, Saioa García-Longarte, Amaia Zabala-Letona, Ianire Astobiza, Sonia Fernández, Alejandro Paniagua, Borja Miguel-López, Virginie Marchand, Diego Alonso-López, Angelika Merkel, Ignacio García-Tuñón, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Mikel Azkargorta, Félix Elortza, Laura Bárcena, Monika Gonzalez-Lopez, Ana M. Aransay, Tomás Di Domenico, Manuel A. Sánchez-Martín, Javier De Las Rivas, Sònia Guil, Yuri Motorin, Mark Helm, Pier Paolo Pandolfi, Arkaitz Carracedo, and Sandra Blanco

Subjects
Epitranscriptome, RNA modifications, Prostate cancer, 7-methylguanosine, tRNA fragments, Tumour microenvironment (TME), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show that the transfer RNA N7-methylguanosine (m7G) transferase METTL1 is highly expressed in primary and advanced prostate tumours. Mechanistically, we find that METTL1 depletion causes the loss of m7G tRNA methylation and promotes the biogenesis of a novel class of small non-coding RNAs derived from 5'tRNA fragments. 5'tRNA-derived small RNAs steer translation control to favour the synthesis of key regulators of tumour growth suppression, interferon pathway, and immune effectors. Knockdown of Mettl1 in prostate cancer preclinical models increases intratumoural infiltration of pro-inflammatory immune cells and enhances responses to immunotherapy. Collectively, our findings reveal a therapeutically actionable role of METTL1-directed m7G tRNA methylation in cancer cell translation control and tumour biology.

Published
2023
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6. Teacher training for social sciences education and a democratic citizenship in a postconflict society: The case of the Basque Country

Author

Aritza Saenz del Castillo Velasco, Joseba Iñaki Arregi-Orue, Leire Agirreazkuenaga Onaidia, and Joseba Jon Longarte Arriola

Subjects
human rights and peace education, victims´ testimonies, memory and history, Basque Country, democratic citizenship, Special aspects of education, LC8-6691, Social sciences (General), H1-99
Abstract

Highlights: • Adi-Adian is an initiative of human rights and peace education implemented at the schools of the Basque Country and related to the experience of victims of political violence • This Adi-Adian initiative has been applied at Teacher Training School upon future teachers of Primary School • The testimony of victims has proven to be effective at rising the empathy and the comprehension of other point of views Purpose: The Basque Country has been suffering political conflict and human rights´ violation for decades, tearing the social fabric. Human rights and peace education carried out through the testimony of the victims and their memory about this recent violent past can play an essential role in reestablishing the social understanding. This article aims to make known the experience of Adi-Adian initiative developed with the victims of the politic violence in the Teacher Training School of the University of Basque Country and asses its effectiveness in terms of critical thinking and empathy. Design/methodology/approach: This research is based on group discussion and personal surveys focused on students´ feedback as a suitable method to analyze the way of thinking of students, their feelings and opinions about the violence. Findings: The results indicate that these initiatives implemented at school might be suitable to achieve the goals of human rights and peace education and deepen on democratic citizenship.

Published
2023
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7. The transcriptional landscape of metastatic hormone-naive prostate cancer

Author

Martin-Martin, Natalia, primary, Garcia-Longarte, Saioa, additional, Corres-Mendizabal, Jon, additional, Lazcano, Uxue, additional, Astobiza, Ianire, additional, Bozal-Basterra, Laura, additional, Herranz, Nicolas, additional, van Splunder, Hielke, additional, Carlevaris, Onintza, additional, Pujana-Vaquerizo, Mikel, additional, Blasco, María Teresa, additional, Aransay, Ana M., additional, Rosino, Antonio, additional, Tudela, Julian, additional, Jimenez, Daniel, additional, Martinez, Alberto, additional, Salca, Andrei, additional, Santos-Martín, Aida, additional, Rey, Sofía, additional, Ugalde-Olano, Aitziber, additional, Gonzalo, David, additional, Graupera, Mariona, additional, Gomis, Roger R., additional, Mateo, Joaquin, additional, Unda, Miguel, additional, Gonzalez-Billalabeitia, Enrique, additional, Loizaga-Iriarte, Ana, additional, Mendizabal, Isabel, additional, and Carracedo, Arkaitz, additional

Published
2024
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8. Influence of coherent adiabatic excitation on femtosecond transient signals

Author

Conde, A. Peralta, Montero, R., and Longarte, A.

Subjects
Physics - Atomic Physics
Abstract

The transient signals derived from femtosecond pump-probe experiments are analyzed in terms of the coherent evolution of the energy levels perturbed by the excitation pulse. The model system is treated as the sum of independent two-level subsystems that evolve adiabatically or are permanently excited, depending on the detuning from the central wavelength of the excitation laser. This approach will allow us to explain numerically and analytically the convergence between the coherent and incoherent (rate equations) treatments for complex multi-level systems. It will be also shown that the parameter that determines the validity of the incoherent treatment is the distribution of states outside and inside the laser bandwidth, rather than the density of states as it is commonly accepted., Comment: 11 pages. 8 Figures

Published
2016

9. Influence of H-bonds on the photoionization of aromatic chromophores in water: The aniline molecule.

Author

Lamas, Iker, González, Jorge, Longarte, Asier, and Montero, Raúl

Subjects
ELECTRONIC excitation, SOLVATED electrons, ANILINE, CHROMOPHORES, PHOTOIONIZATION
Abstract

We have conducted time-resolved experiments (pump–probe and pump–repump–probe) on a model aromatic chromophore, aniline, after excitation in water at 267 nm. In the initial spectra recorded, in addition to the absorption corresponding to the bright ππ* excitation, the fingerprint of a transient state with the electron located on the solvent molecule is identified. We postulate that the latter corresponds to the πσ* state along the N–H bond, whose complete relaxation with a ∼500 ps lifetime results in the formation of the fully solvated electron and cation. This ionization process occurs in parallel with the ππ* photophysical channel that yields the characteristic ∼1 ns fluorescence lifetime. The observed branched pathway is rationalized in terms of the different H-bonds that the water establishes with the amino group. The proposed mechanism could be common for aromatics in water containing N–H or O–H bonds and would allow the formation of separated charges after excitation at the threshold of their electronic absorptions. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Solar Gas-Phase CO2 Hydrogenation by Multifunctional UiO-66 Photocatalysts

Author

Rueda-Navarro, Celia M., primary, Abou Khalil, Zahraa, additional, Melillo, Arianna, additional, Ferrer, Belén, additional, Montero, Raúl, additional, Longarte, Asier, additional, Daturi, Marco, additional, Vayá, Ignacio, additional, El-Roz, Mohamad, additional, Martínez-Martínez, Virginia, additional, Baldoví, Herme G., additional, and Navalón, Sergio, additional

Published
2024
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11. Femtosecond time-resolved photophysics and photodissociation dynamics of 1-iodonaphthalene

Author

Montero Gilete, Raul, Peralta Conde, Alvaro, Longarte Aldama, Asier, Almendral Castaño, Fernando, Corrales Castellanos, María Eugenia, Nalda Míguez, Rebeca de, Bañares Morcillo, Luis, Montero Gilete, Raul, Peralta Conde, Alvaro, Longarte Aldama, Asier, Almendral Castaño, Fernando, Corrales Castellanos, María Eugenia, Nalda Míguez, Rebeca de, and Bañares Morcillo, Luis

Abstract

Depto. de Química Física, Fac. de Ciencias Químicas, TRUE, pub

Published
2024

13. The PP2A regulator IER5L supports prostate cancer progression.

Author

Crespo, Jana R., Martín-Martín, Natalia, Garcia-Longarte, Saioa, Corres-Mendizabal, Jon, Carlevaris, Onintza, Astobiza, Ianire, Zabala-Letona, Amaia, Guiu, Marc, Azkargorta, Mikel, Gonzalez-Lopez, Monika, Macías-Cámara, Nuria, Doan, Phuong, Elortza, Félix, Mendizabal, Isabel, Westermack, Jukka, Gomis, Roger R., Ercilla, Amaia, and Carracedo, Arkaitz

Published
2024
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15. Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer

Author

Santasusagna, Sandra, primary, Zhu, Shijia, additional, Jawalagatti, Vijayakumar, additional, Carceles-Cordon, Marc, additional, Ertel, Adam, additional, Garcia-Longarte, Saioa, additional, Song, Won-Min, additional, Fujiwara, Naoto, additional, Li, Peiyao, additional, Mendizabal, Isabel, additional, Petrylak, Daniel P., additional, Kelly, William Kevin, additional, Reddy, E. Premkumar, additional, Wang, Liguo, additional, Schiewer, Matthew J., additional, Lujambio, Amaia, additional, Karnes, Jeffrey, additional, Knudsen, Karen E., additional, Cordon-Cardo, Carlos, additional, Dong, Haidong, additional, Huang, Haojie, additional, Carracedo, Arkaitz, additional, Hoshida, Yujin, additional, Rodriguez-Bravo, Veronica, additional, and Domingo-Domenech, Josep, additional

Published
2023
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17. Halogen-free photosensitizers based on meso-enamine-BODIPYs for bioimaging and photodynamic therapy

Author

Ruth Prieto-Montero, Aitor Díaz Andres, Alejandro Prieto-Castañeda, Andrea Tabero, Asier Longarte, Antonia R. Agarrabeitia, Angeles Villanueva, María J. Ortiz, Raúl Montero, David Casanova, and Virginia Martínez-Martínez

Subjects
Biomedical Engineering, General Materials Science, General Chemistry, General Medicine
Abstract

By the straightforward incorporation of an enamine group as an electron-donor moiety at meso position of BODIPY core, a halogen-free theragnostic photosensitizer for PDT with ability of bio staining lipid droplets is achieved.

Published
2023
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19. Teacher training for social sciences education and a democratic citizenship in a postconflict society: The case of the Basque Country

Author

SAENZ, ARITZA, Arregi-Orue, Joseba Iñaki, Agirreazkuenaga Onaidia, Leire, and Longarte Arriola, Joseba Jon

Abstract

Highlights: • Adi-Adian is an initiative of human rights and peace education implemented at the schools of the Basque Country and related to the experience of victims of political violence • This Adi-Adian initiative has been applied at Teacher Training School upon future teachers of Primary School • The testimony of victims has proven to be effective at rising the empathy and the comprehension of other point of views Purpose: The Basque Country has been suffering political conflict and human rights´ violation for decades, tearing the social fabric. Human rights and peace education carried out through the testimony of the victims and their memory about this recent violent past can play an essential role in reestablishing the social understanding. This article aims to make known the experience of Adi-Adian initiative developed with the victims of the politic violence in the Teacher Training School of the University of Basque Country and asses its effectiveness in terms of critical thinking and empathy. Design/methodology/approach: This research is based on group discussion and personal surveys focused on students´ feedback as a suitable method to analyze the way of thinking of students, their feelings and opinions about the violence. Findings: The results indicate that these initiatives implemented at school might be suitable to achieve the goals of human rights and peace education and deepen on democratic citizenship., JSSE - Journal of Social Science Education, Bd. 22 (2023): Advance Access Articles

Published
2023
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20. Influence of H-bonds on the photoionization of aromatic chromophores in water: The aniline molecule

Author

Iker Lamas, Jorge González, Asier Longarte, and Raúl Montero

Subjects
General Physics and Astronomy, Physical and Theoretical Chemistry
Abstract

We have conducted time-resolved experiments (pump–probe and pump–repump–probe) on a model aromatic chromophore, aniline, after excitation in water at 267 nm. In the initial spectra recorded, in addition to the absorption corresponding to the bright ππ* excitation, the fingerprint of a transient state with the electron located on the solvent molecule is identified. We postulate that the latter corresponds to the πσ* state along the N–H bond, whose complete relaxation with a ∼500 ps lifetime results in the formation of the fully solvated electron and cation. This ionization process occurs in parallel with the ππ* photophysical channel that yields the characteristic ∼1 ns fluorescence lifetime. The observed branched pathway is rationalized in terms of the different H-bonds that the water establishes with the amino group. The proposed mechanism could be common for aromatics in water containing N–H or O–H bonds and would allow the formation of separated charges after excitation at the threshold of their electronic absorptions.

Published
2023
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22. Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer

Author

Santasusagna, Sandra, Zhu, Shijia, Jawalagatti, Vijayakumar, Carceles-Cordon, Marc, Ertel, Adam, Garcia-Longarte, Saioa, Song, Won-Min, Fujiwara, Naoto, Li, Peiyao, Mendizabal, Isabel, Petrylak, Daniel P., Kelly, William Kevin, Reddy, E. Premkumar, Wang, Liguo, Schiewer, Matthew J., Lujambio, Amaia, Karnes, Jeffrey, Knudsen, Karen E., Cordon-Cardo, Carlos, Dong, Haidong, Huang, Haojie, Carracedo, Arkaitz, Hoshida, Yujin, Rodriguez-Bravo, Veronica, Domingo-Domenech, Josep, Santasusagna, Sandra, Zhu, Shijia, Jawalagatti, Vijayakumar, Carceles-Cordon, Marc, Ertel, Adam, Garcia-Longarte, Saioa, Song, Won-Min, Fujiwara, Naoto, Li, Peiyao, Mendizabal, Isabel, Petrylak, Daniel P., Kelly, William Kevin, Reddy, E. Premkumar, Wang, Liguo, Schiewer, Matthew J., Lujambio, Amaia, Karnes, Jeffrey, Knudsen, Karen E., Cordon-Cardo, Carlos, Dong, Haidong, Huang, Haojie, Carracedo, Arkaitz, Hoshida, Yujin, Rodriguez-Bravo, Veronica, and Domingo-Domenech, Josep

Abstract

Signaling rewiring allows tumors to survive therapy. Here we show that the decrease of the master regulator microphthalmia transcription factor (MITF) in lethal prostate cancer unleashes eukaryotic initiation factor 3B (eIF3B)-dependent translation reprogramming of key mRNAs conferring resistance to androgen deprivation therapy (ADT) and promoting immune evasion. Mechanistically, MITF represses through direct promoter binding eIF3B, which in turn regulates the translation of specific mRNAs. Genome-wide eIF3B enhanced cross-linking immunoprecipitation sequencing (eCLIP-seq) showed specialized binding to a UC-rich motif present in subsets of 5' untranslated regions. Indeed, translation of the androgen receptor and major histocompatibility complex I (MHC-I) through this motif is sensitive to eIF3B amount. Notably, pharmacologic targeting of eIF3B-dependent translation in preclinical models sensitizes prostate cancer to ADT and anti-PD-1 therapy. These findings uncover a hidden connection between transcriptional and translational rewiring promoting therapy-refractory lethal prostate cancer and provide a druggable mechanism that may transcend into effective combined therapeutic strategies. SIGNIFICANCE: Our study shows that specialized eIF3B-dependent translation of specific mRNAs released upon downregulation of the master transcription factor MITF confers castration resistance and immune evasion in lethal prostate cancer. Pharmacologic targeting of this mechanism delays castration resistance and increases immune-checkpoint efficacy. This article is featured in Selected Articles from This Issue, p. 2489.

Published
2023

23. Tracking ultrafast dynamics by sub-20-fs UV pulses generated in the lab open atmosphere

Author

Química física, Kimika fisikoa, Peralta Conde, Álvaro, Lamas Frejo, Iker, Sánchez Albaneda, Marina, Méndez, Cruz, Longarte Aldama, Asier, Montero Santos, Raúl, Química física, Kimika fisikoa, Peralta Conde, Álvaro, Lamas Frejo, Iker, Sánchez Albaneda, Marina, Méndez, Cruz, Longarte Aldama, Asier, and Montero Santos, Raúl

Abstract

This study describes a simple method to generate sub-20 fs UV-pulses (264 nm) by third-harmonic generation, in an air-plasma filament formed after focusing the fundamental 800 nm beam directly in the lab open-atmosphere. The generated pulses are applied to track the relaxation through the conical intersection that couples the S2 and S1 states, in the benchmark molecule of naphthalene. The transients, with a resolution of about 25 fs, show two differentiate patterns of quantum beats. The assignation of these oscillations to specific modes in the lower S1 state and to electronic coherence between the two coupled states is discussed.

Published
2023

24. METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Author

Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Castilla y León, Universidad de Salamanca, Banco Santander, Asociación Española Contra el Cáncer, Fundación CRIS contra el Cáncer, Fundación la Caixa, European Research Council, European Commission, García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Castilla y León, Universidad de Salamanca, Banco Santander, Asociación Española Contra el Cáncer, Fundación CRIS contra el Cáncer, Fundación la Caixa, European Research Council, European Commission, García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Abstract

Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show that the transfer RNA N7-methylguanosine (m7G) transferase METTL1 is highly expressed in primary and advanced prostate tumours. Mechanistically, we find that METTL1 depletion causes the loss of m7G tRNA methylation and promotes the biogenesis of a novel class of small non-coding RNAs derived from 5'tRNA fragments. 5'tRNA-derived small RNAs steer translation control to favour the synthesis of key regulators of tumour growth suppression, interferon pathway, and immune effectors. Knockdown of Mettl1 in prostate cancer preclinical models increases intratumoural infiltration of pro-inflammatory immune cells and enhances responses to immunotherapy. Collectively, our findings reveal a therapeutically actionable role of METTL1-directed m7G tRNA methylation in cancer cell translation control and tumour biology.

Published
2023

25. Additional file 10 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

26. Additional file 7 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

27. Additional file 8 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

28. Additional file 9 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

29. Additional file 2 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

30. Additional file 3 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

31. Additional file 4 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

32. Additional file 6 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

33. Additional file 5 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

34. Halogen-free photosensitizers based on meso-enamine-BODIPYs for bioimaging and photodynamic therapy

Author

Prieto-Montero, Ruth, primary, Díaz Andres, Aitor, additional, Prieto-Castañeda, Alejandro, additional, Tabero, Andrea, additional, Longarte, Asier, additional, Agarrabeitia, Antonia R., additional, Villanueva, Angeles, additional, Ortiz, María J., additional, Montero, Raúl, additional, Casanova, David, additional, and Martínez-Martínez, Virginia, additional

Published
2023
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35. Halogen-free photosensitizers based on

Author

Ruth, Prieto-Montero, Aitor, Díaz Andres, Alejandro, Prieto-Castañeda, Andrea, Tabero, Asier, Longarte, Antonia R, Agarrabeitia, Angeles, Villanueva, María J, Ortiz, Raúl, Montero, David, Casanova, and Virginia, Martínez-Martínez

Subjects
Photosensitizing Agents, Halogens, Photochemotherapy, Humans, HeLa Cells
Abstract

The search for efficient heavy atom free photosensitizers (PSs) for photodynamic therapy (PDT) is a very active field. We describe herein a simple and easily accessible molecular design based on the attachment of an enamine group as an electron-donor moiety at the

Published
2022

36. Giza eskubideetarako hezkuntza gatazka osteko gizartean. Teoriatik praktikara

Author

Joseba Jon Longarte Arriola, Ana Isabel Ugalde Gorostiza, Joseba Iñaki Arregi Orue, and Aritza Saenz del Castillo

Abstract

EnglishThe educational community is aware of the importance of Human Rights Education for an inclusive society. Thus, the knowledge of theses inviolable rights is essential, and students should be aware of their violation. Starting from the objective of a true democratic society, we must avoid such attitudes, denouncing them and looking for possible solutions. In summary, Human Rights Education seeks to create critical human groups and individuals by making our students active, participatory and transformative citizens, in order to facilitate civic coexistence. For this end, the students of the Faculty of Education of Vitoria-Gasteiz carried out an introductory analytical task within Adi-Adian module, where they put in contact the different civil, social, cultural and political Human Rights and the reality, developing part of the objectives and contents of the Social and Civic Competence satisfactorily. Furthermore, the students will reflect about this learning process through a co-assessment task, which shows positive results euskaraAspalditik Giza Eskubideetarako Hezkuntzaren garrantziaz jabetu gara hezkuntza-komunitatean. Hori horrela, pertsona orori gizaki izateagatik dagozkion eskubide bortxaezinen ezagutza ezinbestekoa da, eta ikasleei gizartean gertatzen diren eskubideen urraketez ohartarazi behar zaie. Benetako berdintasunean oinarritutako gizarte demokratikoa helburutzat izanda, horrelako jarrerak ekidin beharrean gaude, horiek salatuz eta horiei aurre egiteko irtenbideak bilaraziz. Azken finean, Giza Eskubideetarako Hezkuntzaren bidez gizabanako eta gizatalde kritikoak sortu nahian gaude, gure ikasleak herritar aktiboak, parte-hartzaileak eta eraldatzaileak bilakatuz eta bizikidetza erraztuko duten subjektuak sorraraziz. Horretarako, Gasteizko Hezkuntza Fakultateko ikasleekin hasierako praktika analitiko bat egin da Adi-Adian moduluaren barnean, non Giza Eskubideen Aldarrikapen Unibertsalaren eskubide zibil, politiko, sozial eta kulturalak egungo berriekin harremanetan jarri diren; bide batez, Konpetentzia Sozial eta Zibikoa garatu eta ikasleak Giza Eskubideetarako Hezkuntzaren praktikotasunaz jabetu dira. Bestalde, koebaluazio-ariketa baten bidez, ikasleek ikaskuntza-prozesu honi buruzko hausnarketa egin dute, eta emaitza positiboak lortu.

Published
2021
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37. Revisiting the Spectroscopy of Water Dimer in Jets

Author

Asier Longarte, Raúl Montero, José A. Fernández, and Iker León

Subjects
Water dimer, Materials science, 010304 chemical physics, Chemical physics, 0103 physical sciences, General Materials Science, Physical and Theoretical Chemistry, 010402 general chemistry, Spectroscopy, 01 natural sciences, 0104 chemical sciences
Abstract

Laser spectroscopy in jets is one of the main sources of structural data from molecular aggregates. Consequently, numerous and sophisticated experimental systems have been developed to extract precise information, which is usually interpreted in the light of quantum mechanical calculations. However, even with the most sophisticated experiments, it is sometimes difficult to interpret the experimental results. We present here the example of water dimer and how after almost 70 years, the assignment of its mass-resolved IR spectrum still generates controversy that extends toward the mechanism of ionization of water aggregates.

Published
2021
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39. Teacher training for social sciences education and a democratic citizenship in a postconflict society. The case of the Basque Country.

Author

del Castillo Velasco, Aritza Sáenz, Arregi-Orue, Joseba Iñaki, Onaidia, Leire Agirreazkuenaga, and Arriola, Joseba Jon Longarte

Subjects
TEACHER training, SOCIAL sciences, CITIZENSHIP
Abstract

Highlights: -Adi-Adian is an initiative of human rights and peace education implemented at the schools of the Basque Country and related to the experience of victims of political violence -This Adi-Adian initiative has been applied at Teacher Training School upon future teachers of Primary School -The testimony of victims has proven to be effective at rising the empathy and the comprehension of other point of views Purpose: The Basque Country has been suffering political conflict and human rights' violation for decades, tearing the social fabric. Human rights and peace education carried out through the testimony of the victims and their memory about this recent violent past can play an essential role in reestablishing the social understanding. This article aims to make known the experience of Adi-Adian initiative developed with the victims of the politic violence in the Teacher Training School of the University of Basque Country and asses its effectiveness in terms of critical thinking and empathy. Design/methodology/approach: This research is based on group discussion and personal surveys focused on students' feedback as a suitable method to analyze the way of thinking of students, their feelings and opinions about the violence. Findings: The results indicate that these initiatives implemented at school might be suitable to achieve the goals of human rights and peace education and deepen on democratic citizenship. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Tracking ultrafast dynamics by sub-20-fs UV pulses generated in the lab open atmosphere

Author

Álvaro Peralta Conde, Iker Lamas, Marina Sánchez Albaneda, Cruz Méndez, Asier Longarte, and Raúl Montero

Subjects
electronic coherence, conical intersection, General Physics and Astronomy, wavepacket, Physical and Theoretical Chemistry, sub-20 fs UV pulses, electronic relaxation, non-adiabatic coupling
Abstract

This study describes a simple method to generate sub-20 fs UV-pulses (264 nm) by third-harmonic generation, in an air-plasma filament formed after focusing the fundamental 800 nm beam directly in the lab open-atmosphere. The generated pulses are applied to track the relaxation through the conical intersection that couples the S2 and S1 states, in the benchmark molecule of naphthalene. The transients, with a resolution of about 25 fs, show two differentiate patterns of quantum beats. The assignation of these oscillations to specific modes in the lower S1 state and to electronic coherence between the two coupled states is discussed. All the experiments were carried out at the CLPU facility. The authors acknowledge the assistance from the CLPU technical and administrative personnel. They also thank the financial support from the Spanish MINECO through the grant: PGC2018-098561-B-C21. The work was also funded by the Basque Government (IT1162-19 and IT1491-22). I. Lamas thanks the UPV/EHU for his predoctoral fellowship. Technical and human support provided by SGIker (UPV/EHU, MICINN, GV/EJ, ESF) is also gratefully acknowledged. The authors greatly appreciate the Open Access funding provided by University of Basque Country.

Published
2023
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45. Halogen-free photosensitizers based on meso-enamine-BODIPYs for bioimaging and photodynamic therapy

Author

Prieto Montero, Ruth, Díaz Andrés, Aitor, Prieto Castañeda, Alejandro, Tabero Truchado, Andrea, Longarte Aldama, Asier, Rodríguez Agarrabeitia, Antonia, Villanueva Oroquieta, Ángeles, Ortíz García, María Josefa, Montero Santos, Raul, Casanova, David, Martínez Martínez, Virginia, Prieto Montero, Ruth, Díaz Andrés, Aitor, Prieto Castañeda, Alejandro, Tabero Truchado, Andrea, Longarte Aldama, Asier, Rodríguez Agarrabeitia, Antonia, Villanueva Oroquieta, Ángeles, Ortíz García, María Josefa, Montero Santos, Raul, Casanova, David, and Martínez Martínez, Virginia

Abstract

Received 18th July 2022, Accepted 23rd November 2022, The search for efficient heavy atom free photosensitizers (PSs) for photodynamic therapy (PDT) is a very active field. We describe herein a simple and easily accessible molecular design based on the attachment of an enamine group as an electron-donor moiety at the meso position of the BODIPY core with different alkylation patterns. The effect of the alkylation degree and solvent polarity on the photophysical properties in terms of splitting absorption bands, fluorescence efficiencies and singlet oxygen production is analyzed in depth experimentally using spectroscopic techniques, including femtosecond and nanosecond transient absorption (fs- and ns-TA) and using computational simulations based on time-dependent density functional theory. The correlation between the theoretical/experimental results permits the rationalization of the observed photophysical behavior exhibited by meso-enamine-BODIPY compounds and the determination of mechanistic details, which rule the population of the triplet state manifold. The potential applicability as a theragnostic agent for the most promising compound is demonstrated through in vitro assays in HeLa cells by analyzing the internalization, localization and phototoxic action., MCIN/AEI/10.13039/501100011033, Gobierno vasco (España), Sección Deptal. de Química Orgánica (Óptica y Optometría), Fac. de Óptica y Optometría, TRUE, pub

Published
2022

46. Ultrafast Dynamics in Isolated Molecules, Molecular Clusters and Solutions: Filling the Gap between the Gas- and Condensed-Phases

Author

Montero Santos, Raúl, Longarte Aldama, Asier, Química física, Kimika fisikoa, Lamas Frejo, Iker, Montero Santos, Raúl, Longarte Aldama, Asier, Química física, Kimika fisikoa, and Lamas Frejo, Iker

Abstract

222 p.(eng.) 133 p. (eusk.), El objetivo fundamental de la presente Tesis Doctoral reside en entender cuáles son los principales caminos de relajación fotofísicos y fotoquímicos disponibles en moléculas biológicamente relevantes, además de evaluar como los cambios estructurales y/o las interacciones intermoleculares son capaces de alterar la fotoestabilidad de estas especies. Para ello, se ha investigado la dinámica de relajación de diferentes sistemas moleculares, tanto en fase gas como en fase condensada, mediante técnicas espectroscópicas resueltas en el tiempo con resolución de femtosegundos. La primera parte de la memoria, se centra en explicar brevemente los conceptos fundamentales asociados a la dinámica molecular y en describir los distintos sistemas experimentales y métodos computacionales empleados. El primer sistema estudiado ha sido la familia de los azaindoles debido a que están considerados como precursores estructurales de las bases purínicas del ADN. Así mismo, también se ha investigado la influencia de las interacciones intermoleculares en cromóforos aromáticos como el pirrol o la anilina. Finalmente, se ha explorado experimentalmente y mediante cálculos computacionales la influencia de los sustituyentes en la fotoestabilidad de cuatro fotoprotectores sintécticos.

Published
2022

49. An nπ* gated decay mediates excited-state lifetimes of isolated azaindoles

Author

Iker Lamas, Lluís Blancafort, Raúl Montero, Virginia Martínez-Martínez, and Asier Longarte

Subjects
Physics, 010405 organic chemistry, Relaxation (NMR), General Physics and Astronomy, Conical intersection, 010402 general chemistry, 01 natural sciences, Molecular physics, Spectral line, 0104 chemical sciences, Excited state, Ionization, Femtosecond, Physical and Theoretical Chemistry, Ground state, Excitation
Abstract

Aiming to serve as a guide to understand the relaxation mechanisms of more complex aza-aromatic compounds, such as purine bases, we have studied the non-radiative channels of a set of azaindole structural isomers: 4-, 5-, 6- and 7-azaindole (AI). The relaxation of the isolated molecules, after excitation at the low energy portion of their spectra, has been tracked by femtosecond time-resolved ionization, and the decay paths have been obtained with MS-CASPT2//TD-DFT calculations. Although the ultrashort measured lifetimes for 5- and 6-AI are in contrast to the long-living excited state found in 7-AI, the calculations describe a common relaxation pathway. Along it, the initially excited ππ* states decay to the ground state through a conical intersection accessed through an nπ* state that functions as a gate state. The work reveals that the position of the nitrogen atoms in the purine ring determines the barrier to access the gate state and therefore, the rate of the non-radiative relaxation.

Published
2020
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50. Dynamics of Pyrroles Excited to the 3s/πσ* State

Author

Raúl Montero, Alvaro Peralta Conde, Iker Lamas, Dave Townsend, Gonzalo Muga, and Asier Longarte

Subjects
Valence (chemistry), 010304 chemical physics, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, symbols.namesake, chemistry, Chemical physics, Excited state, 0103 physical sciences, Physics::Atomic and Molecular Clusters, Rydberg formula, symbols, Physical and Theoretical Chemistry, Pyrrole
Abstract

The available experimental data provided by ultrafast dynamics studies of pyrrole and its derivatives in excited states of mixed Rydberg/valence 3s/πσ* character are strongly affected by the interaction with the laser pulses. Understanding these data has constituted an endeavor for several groups during the past few years. Here we apply a simple theoretical model that, including the interaction with the laser pulses, allows one to clarify some aspects of the discrepancies between measurements monitoring different experimental observables. New experimental data on pyrrole, 2,4-dimethylpyrrole, and 2,5-dimethylpyrrole are also provided to check the validity of the model and to gain more insight into the excited state dynamics of pyrrole systems.

Published
2019
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