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14 results on '"Long, Zhisheng"'

4. Chestnut-Inspired Hollow Hydroxyapatite 3D Printing Scaffolds Accelerate Bone Regeneration by Recruiting Calcium Ions and Regulating Inflammation

Author

Wei, Peng, primary, Zhou, Jingyu, additional, Xiong, Shilang, additional, Yi, Feng, additional, Xu, Kejun, additional, Liu, Min, additional, Xi, Hanrui, additional, Zhou, Zhigang, additional, Qiu, Zhiqiang, additional, Liu, Hantian, additional, Zeng, Jianhua, additional, Liu, Yayun, additional, Qiu, Peng, additional, Zhou, Jianguo, additional, Liu, Shiwei, additional, Long, Zhisheng, additional, Li, Jingtang, additional, and Xiong, Long, additional

Published
2024
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5. pH-Responsive nanoplatform synergistic gas/photothermal therapy to eliminate biofilms in poly(L-lactic acid) scaffolds.

Author

Qian, Guowen, Mao, Yuqian, Zhao, Huihui, Zhang, Lemin, Xiong, Long, and Long, Zhisheng

Abstract

To date, implant-associated infection is still a significant clinical challenge, which cannot be effectively eliminated by single therapies due to the formation of microbial biofilms. Herein, a pH-responsive nanoplatform was constructed via the in situ growth of zinc sulfide (ZnS) nanoparticles on the surface of Ti3C2 MXene nanosheets, which was subsequently introduced in poly(L -lactic acid) (PLLA) to prepare a composite bone scaffold via selective laser sintering technology. In the acidic biofilm microenvironment, the degradation of ZnS released hydrogen sulfide (H2S) gas to eliminate the biofilm extracellular DNA (eDNA), thus destroying the compactness of the biofilm. Then, the bacterial biofilm became sensitive to hyperthermia, which could be further destroyed under near-infrared light irradiation due to the excellent photothermal property of MXene, finally achieving gas/photothermal synergistic antibiofilm and efficient sterilization. The results showed that the synergistic gas/photothermal therapy for the composite scaffold not only evidently inhibited the formation of biofilms, but also effectively eradicated the eDNA of the already-formed biofilms and killed 90.4% of E. coli and 84.2% of S. aureus under near infrared light irradiation compared with single gas or photothermal therapy. In addition, the composite scaffold promoted the proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells. Thus, the designed scaffold with excellent biofilm elimination and osteogenesis ability has great potential as an alternative treatment for implant-associated bone infections. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Hollow Hydroxyapatite Microspheres Loaded with rhCXCL13 to Recruit BMSC for Osteogenesis and Synergetic Angiogenesis to Promote Bone Regeneration in Bone Defects

Author

Zeng, Jianhua, primary, Xiong, Shilang, additional, Zhou, Jingyu, additional, Wei, Peng, additional, Guo, Kai, additional, Wang, Feng, additional, Ouyang, Min, additional, Long, Zhisheng, additional, Yao, Aihua, additional, Li, Jingtang, additional, Xiong, Long, additional, and Wu, Desheng, additional

Published
2023
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10. Hollow Hydroxyapatite Microspheres Loaded with rhCXCL13 to Recruit BMSC for Osteogenesis and Synergetic Angiogenesis to Promote Bone Regeneration in Bone Defects

Author

Zeng,Jianhua, Xiong,Shilang, Zhou,Jingyu, Wei,Peng, Guo,Kai, Wang,Feng, Ouyang,Min, Long,Zhisheng, Yao,Aihua, Li,Jingtang, Xiong,Long, Wu,Desheng, Zeng,Jianhua, Xiong,Shilang, Zhou,Jingyu, Wei,Peng, Guo,Kai, Wang,Feng, Ouyang,Min, Long,Zhisheng, Yao,Aihua, Li,Jingtang, Xiong,Long, and Wu,Desheng

Abstract

Jianhua Zeng,1,2,* Shilang Xiong,3,* Jingyu Zhou,4 Peng Wei,4 Kai Guo,1 Feng Wang,1 Min Ouyang,4 Zhisheng Long,5 Aihua Yao,6 Jingtang Li,7 Long Xiong,4 Desheng Wu1 1Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China; 2Department of Spine Surgery, People’s Hospital of Ganxian District, Ganzhou, Jiangxi, 341100, China; 3Department of Orthopedics, the First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, Jiangxi, 330006, China; 4Department of Orthopedics, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China; 5Department of Spine Surgery, Jiangxi Provincial People’s Hospital the First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, China; 6School of Materials Science and Engineering, Tongji University, Shanghai, 201804, China; 7Department of Traumatology, Jiangxi provincial People’s Hospital the First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, China*These authors contributed equally to this workCorrespondence: Desheng Wu; Long Xiong, Email 1300116@tongji.edu.cn; ncxionglong2@126.comIntroduction: Bone tissue engineering is a promising method to treat bone defects. However, the current methods of preparing composite materials that mimic the complex structure and biological activity of natural bone are challenging for recruitment of bone marrow mesenchymal stem cells (BMSCs), which affects the application of these materials in situ bone regeneration. Hollow hydroxyapatite microspheres (HHMs) possess a natural porous bone structure, good adsorption, and slow release of chemokines, but have low ability to recruit BMSCs and induce osteogenesis. In this study, The HHM/chitosan (CS) and recombinant human C-X-C motif chemokine ligand 13 (rhCXCL13)-HHM/CS biomimetic scaffolds that optimize bone regeneration an

Published
2023

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