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22 results on '"Long, W.M."'

17. Environmental lead-210 and bismuth-210 accrue selectively in the brain proteins in Alzheimer disease and brain lipids in Parkinson disease

Author

Momčilović, Berislav, AlKhatib, H.A, Duerre, J.A, Cooley, M.A, Long, W.M, Harris, R.T, and Lykken, G.I

Subjects
environmental radon daughters, Parkinson disease, cigarette smoking, brain proteins and lipids, radiochemical injury, respiratory tract diseases
Abstract

We studied the occurrence of the environmental radon daughters, Po-210 (alpha particles), and Bi-210 (beta particles), in the protein and lipid fractions of cortical gray and subcortical white matter from the frontal and temporal lobes of human brains of persons with Alzheimer disease (AD), persons with Parkinson disease (PD), smokers, or persons with no previous evidence of clinical neurologic disease (controls). We found a 10-fold increase in Po-210 and Pb-210 radioactivity in the protein fraction from both the cortical gray and subcortical white matter in AD and smokers, and a similar increase in the lipid fraction in PD. The pathognomonic distribution of the radon daughters to the lipids in PD and to the proteins in AD was inferred to reflect the increase of local chlorine availability to which radon daughters bound selectively. Cigarette smoking strongly increases radon daughter retention in the central nervous system.

Published
2001

18. Environmental radon daughters reveal pathognomonic changes in the brain proteins and lipids in patients with Alzheimer's Disease and Parkinson's Disease, and cigarette smokers

Author

Momčilović, Berislav, AlKhatib, H.A, Duerre, J.A, Cooley, M.A, Long, W.M, Harris R.T, and Lykken G.I.

Subjects
cell membrane impairment, chlorine hypothesis, radiochemical injury, systemic brain disease, respiratory tract diseases
Abstract

This paper presents an investigation of the retention of environmental radon daughters 210Po (alpha particle emitting radio-nuclide), and 210Bi (beta particle emitting radio-nuclide), in lipid and protein fractions of the cortical grey and subcortical white matter from the frontal and temporal brain lobes of patients who suffered from Alzheimer's disease and Parkinson's disease, of cigarette smokers, and of control subjects. 210Po and 210Bi radioactivity increased tenfold in the cortical grey and subcortical white protein fraction in patients with Alzheimer's disease and smokers, and tenfold in the cortical grey and subcortical white lipid frcation in patients with Parkinson's disese. Free radicals generated by radon daughtersmay add to the severity of the radio-chemical injury to the brain astrocytes. The pathognomonic distribution of radon daughters to čipids in patients with Parkinson's disese and to proteins in patients with Alzheimer's disease was attributed to high chlorine affinity of radon daughters. The changes in the membrane protein pores, channels, and gates in patients with Alzheimer's disease and in the lipid bilayer in patients with Parkinson's disease are at the core of what the authors think are two systemic brain diseases

Published
1999

19. Development of the Nontechnical Skills for Officers of the Deck (NTSOD) Rating Form

Author

NAVAL POSTGRADUATE SCHOOL MONTEREY CA, Long, W.M., NAVAL POSTGRADUATE SCHOOL MONTEREY CA, and Long, W.M.

Abstract

This thesis describes the need for and development of the Nontechnical Skills for Officers of the Deck rating form. The purpose of the NTSOD rating system is to provide a framework for evaluating the nontechnical skills of U.S. Navy Surface Warfare Officers of the Deck (OOD). Nontechnical skills are the cognitive, social, and personal skills that complement technical skills. The NTSOD system supplements the current OOD qualification process by providing an objective and documented assessment of the nontechnical skills of OOD candidates. The system consists of four categories of behavior (leadership, communication, situational awareness, and decision making), which are subdivided into 10 more specific, and observable, elements of behavior. The framework was developed through the analysis of data collected from qualified OODs. When properly utilized, the authors believe that the NTSOD system can improve the skills of OODs, and increase the overall mission effectiveness and safety of the surface fleet by providing feedback on a crucial aspect of OOD performance that is not consistently evaluated across the Surface Fleet., The original document contains color images.

Published
2010

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