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2. An expanded universe of cancer targets

Author

Hahn, William C, Bader, Joel S, Braun, Theodore P, Califano, Andrea, Clemons, Paul A, Druker, Brian J, Ewald, Andrew J, Fu, Haian, Jagu, Subhashini, Kemp, Christopher J, Kim, William, Kuo, Calvin J, McManus, Michael T, B. Mills, Gordon, Mo, Xiulei, Sahni, Nidhi, Schreiber, Stuart L, Talamas, Jessica A, Tamayo, Pablo, Tyner, Jeffrey W, Wagner, Bridget K, Weiss, William A, Gerhard, Daniela S, Dancik, Vlado, Gill, Shubhroz, Hua, Bruce, Sharifnia, Tanaz, Viswanathan, Vasanthi, Zou, Yilong, Dela Cruz, Filemon, Kung, Andrew, Stockwell, Brent, Boehm, Jesse, Dempster, Josh, Manguso, Robert, Vazquez, Francisca, Cooper, Lee AD, Du, Yuhong, Ivanov, Andrey, Lonial, Sagar, Moreno, Carlos S, Niu, Qiankun, Owonikoko, Taofeek, Ramalingam, Suresh, Reyna, Matthew, Zhou, Wei, Grandori, Carla, Shmulevich, Ilya, Swisher, Elizabeth, Cai, Jitong, Chan, Issac S, Dunworth, Matthew, Ge, Yuchen, Georgess, Dan, Grasset, Eloïse M, Henriet, Elodie, Knútsdóttir, Hildur, Lerner, Michael G, Padmanaban, Veena, Perrone, Matthew C, Suhail, Yasir, Tsehay, Yohannes, Warrier, Manisha, Morrow, Quin, Nechiporuk, Tamilla, Long, Nicola, Saultz, Jennifer, Kaempf, Andy, Minnier, Jessica, Tognon, Cristina E, Kurtz, Stephen E, Agarwal, Anupriya, Brown, Jordana, Watanabe-Smith, Kevin, Vu, Tania Q, Jacob, Thomas, Yan, Yunqi, Robinson, Bridget, Lind, Evan F, Kosaka, Yoko, Demir, Emek, Estabrook, Joseph, Grzadkowski, Michael, Nikolova, Olga, Chen, Ken, Deneen, Ben, Liang, Han, Bassik, Michael C, Bhattacharya, Asmita, Brennan, Kevin, Curtis, Christina, Gevaert, Olivier, Ji, Hanlee P, Karlsson, Kasper AJ, Karagyozova, Kremena, Lo, Yuan-Hung, Liu, Katherine, Nakano, Michitaka, Sathe, Anuja, and Smith, Amber R

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Biotechnology, Genetics, Orphan Drug, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Animals, Clinical Trials as Topic, Disease Models, Animal, Drug Delivery Systems, Genomics, Humans, Neoplasms, Tumor Escape, Tumor Microenvironment, Cancer Target Discovery and Development Network, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation.

Published
2021

5. Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML

Author

Yang, Fei, Long, Nicola, Anekpuritanang, Tauangtham, Bottomly, Daniel, Savage, Jonathan C., Lee, Tiffany, Solis-Ruiz, Jose, Borate, Uma, Wilmot, Beth, Tognon, Cristina, Bock, Allison M., Pollyea, Daniel A., Radhakrishnan, Saikripa, Radhakrishnan, Srinidhi, Patel, Prapti, Collins, Robert H., Tantravahi, Srinivas, Deininger, Michael W., Fan, Guang, Druker, Brian, Shinde, Ujwal, Tyner, Jeffrey W., Press, Richard D., McWeeney, Shannon, and Agarwal, Anupriya

Published
2022
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8. Mapping the proteogenomic landscape enables prediction of drug response in acute myeloid leukemia

Author

Pino, James C., primary, Posso, Camilo, additional, Joshi, Sunil K., additional, Nestor, Michael, additional, Moon, Jamie, additional, Hansen, Joshua R., additional, Hutchinson-Bunch, Chelsea, additional, Gritsenko, Marina A., additional, Weitz, Karl K., additional, Watanabe-Smith, Kevin, additional, Long, Nicola, additional, McDermott, Jason E., additional, Druker, Brian J., additional, Liu, Tao, additional, Tyner, Jeffrey W., additional, Agarwal, Anupriya, additional, Traer, Elie, additional, Piehowski, Paul D., additional, Tognon, Cristina E., additional, Rodland, Karin D., additional, and Gosline, Sara J.C., additional

Published
2024
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9. Table S4 from Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy

Author

Eide, Christopher A., primary, Kurtz, Stephen E., primary, Kaempf, Andy, primary, Long, Nicola, primary, Joshi, Sunil Kumar, primary, Nechiporuk, Tamilla, primary, Huang, Ariane, primary, Dibb, Charles A., primary, Taylor, Akosha, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Minnier, Jessica, primary, Lachowiez, Curtis A., primary, Saultz, Jennifer N., primary, Swords, Ronan T., primary, Agarwal, Anupriya, primary, Chang, Bill H., primary, Druker, Brian J., primary, and Tyner, Jeffrey W., primary

Published
2023
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10. Supplementary Figure S2 from Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy

Author

Eide, Christopher A., primary, Kurtz, Stephen E., primary, Kaempf, Andy, primary, Long, Nicola, primary, Joshi, Sunil Kumar, primary, Nechiporuk, Tamilla, primary, Huang, Ariane, primary, Dibb, Charles A., primary, Taylor, Akosha, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Minnier, Jessica, primary, Lachowiez, Curtis A., primary, Saultz, Jennifer N., primary, Swords, Ronan T., primary, Agarwal, Anupriya, primary, Chang, Bill H., primary, Druker, Brian J., primary, and Tyner, Jeffrey W., primary

Published
2023
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11. Data from Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy

Author

Eide, Christopher A., primary, Kurtz, Stephen E., primary, Kaempf, Andy, primary, Long, Nicola, primary, Joshi, Sunil Kumar, primary, Nechiporuk, Tamilla, primary, Huang, Ariane, primary, Dibb, Charles A., primary, Taylor, Akosha, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Minnier, Jessica, primary, Lachowiez, Curtis A., primary, Saultz, Jennifer N., primary, Swords, Ronan T., primary, Agarwal, Anupriya, primary, Chang, Bill H., primary, Druker, Brian J., primary, and Tyner, Jeffrey W., primary

Published
2023
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13. Genomic landscape of neutrophilic leukemias of ambiguous diagnosis

Author

Zhang, Haijiao, Wilmot, Beth, Bottomly, Daniel, Dao, Kim-Hien T., Stevens, Emily, Eide, Christopher A., Khanna, Vishesh, Rofelty, Angela, Savage, Samantha, Reister Schultz, Anna, Long, Nicola, White, Libbey, Carlos, Amy, Henson, Rachel, Lin, Chenwei, Searles, Robert, Collins, Robert H., DeAngelo, Daniel J., Deininger, Michael W., Dunn, Tamara, Hein, Than, Luskin, Marlise R., Medeiros, Bruno C., Oh, Stephen T., Pollyea, Daniel A., Steensma, David P., Stone, Richard M., Druker, Brian J., McWeeney, Shannon K., Maxson, Julia E., Gotlib, Jason R., and Tyner, Jeffrey W.

Published
2019
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15. Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy

Author

Eide, Christopher A., primary, Kurtz, Stephen E., additional, Kaempf, Andy, additional, Long, Nicola, additional, Joshi, Sunil Kumar, additional, Nechiporuk, Tamilla, additional, Huang, Ariane, additional, Dibb, Charles A., additional, Taylor, Akosha, additional, Bottomly, Daniel, additional, McWeeney, Shannon K., additional, Minnier, Jessica, additional, Lachowiez, Curtis A., additional, Saultz, Jennifer N., additional, Swords, Ronan T., additional, Agarwal, Anupriya, additional, Chang, Bill H., additional, Druker, Brian J., additional, and Tyner, Jeffrey W., additional

Published
2023
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18. Functional genomic landscape of acute myeloid leukaemia

Author

Tyner, Jeffrey W., Tognon, Cristina E., Bottomly, Daniel, Wilmot, Beth, Kurtz, Stephen E., Savage, Samantha L., Long, Nicola, Schultz, Anna Reister, Traer, Elie, Abel, Melissa, Agarwal, Anupriya, Blucher, Aurora, Borate, Uma, Bryant, Jade, Burke, Russell, Carlos, Amy, Carpenter, Richie, Carroll, Joseph, Chang, Bill H., Coblentz, Cody, d’Almeida, Amanda, Cook, Rachel, Danilov, Alexey, Dao, Kim-Hien T., Degnin, Michie, Devine, Deirdre, Dibb, James, Edwards, V, David K., Eide, Christopher A., English, Isabel, Glover, Jason, Henson, Rachel, Ho, Hibery, Jemal, Abdusebur, Johnson, Kara, Johnson, Ryan, Junio, Brian, Kaempf, Andy, Leonard, Jessica, Lin, Chenwei, Liu, Selina Qiuying, Lo, Pierrette, Loriaux, Marc M., Luty, Samuel, Macey, Tara, MacManiman, Jason, Martinez, Jacqueline, Mori, Motomi, Nelson, Dylan, Nichols, Ceilidh, Peters, Jill, Ramsdill, Justin, Rofelty, Angela, Schuff, Robert, Searles, Robert, Segerdell, Erik, Smith, Rebecca L., Spurgeon, Stephen E., Sweeney, Tyler, Thapa, Aashis, Visser, Corinne, Wagner, Jake, Watanabe-Smith, Kevin, Werth, Kristen, Wolf, Joelle, White, Libbey, Yates, Amy, Zhang, Haijiao, Cogle, Christopher R., Collins, Robert H., Connolly, Denise C., Deininger, Michael W., Drusbosky, Leylah, Hourigan, Christopher S., Jordan, Craig T., Kropf, Patricia, Lin, Tara L., Martinez, Micaela E., Medeiros, Bruno C., Pallapati, Rachel R., Pollyea, Daniel A., Swords, Ronan T., Watts, Justin M., Weir, Scott J., Wiest, David L., Winters, Ryan M., McWeeney, Shannon K., and Druker, Brian J.

Published
2018
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19. Supplementary Table 5 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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20. Supplementary Table 4 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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21. Supplementary Table 9 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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22. Supplementary Table 2 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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23. Supplementary Fig. 11 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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24. Supplementary Table 7 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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25. Supplementary Table 11 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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26. Supplementary Fig. 3 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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27. Supplementary Fig. 6 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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28. Data from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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29. Supplementary Fig. 5 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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30. Supplementary Table 6 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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31. Supplementary Fig. 7 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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32. Supplementary Table 8 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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33. Supplementary Fig. 4 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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34. Supplementary Materials and Methods from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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35. Supplementary Table 3 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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36. Supplementary Fig. 2 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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37. Supplementary Fig. 9 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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38. Supplementary Fig. 8 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., primary, Coleman, Daniel J., primary, VanCampen, Jake, primary, Kong, Garth, primary, Macaraeg, Jommel, primary, Estabrook, Joseph, primary, Demir, Emek, primary, Long, Nicola, primary, Bottomly, Daniel, primary, McWeeney, Shannon K., primary, Tyner, Jeffrey W., primary, Druker, Brian J., primary, Maxson, Julia E., primary, and Braun, Theodore P., primary

Published
2023
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39. Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., additional, Coleman, Daniel J., additional, VanCampen, Jake, additional, Kong, Garth, additional, Macaraeg, Jommel, additional, Estabrook, Joseph, additional, Demir, Emek, additional, Long, Nicola, additional, Bottomly, Daniel, additional, McWeeney, Shannon K., additional, Tyner, Jeffrey W., additional, Druker, Brian J., additional, Maxson, Julia E., additional, and Braun, Theodore P., additional

Published
2023
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41. Defining Clinical and Molecular Biomarkers for Venetoclax-Based Drug Combinations to Augment AML Therapy

Author

Eide, Christopher A., primary, Kurtz, Stephen E., additional, Kaempf, Andy, additional, Long, Nicola, additional, Joshi, Sunil K, additional, Nechiporuk, Tamilla, additional, Huang, Ariane, additional, Dibb, Charles, additional, Bottomly, Daniel, additional, McWeeney, Shannon K., additional, Chang, Bill H., additional, Druker, Brian J., additional, and Tyner, Jeffrey W., additional

Published
2022
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42. Integrative analysis of drug response and clinical outcome in acute myeloid leukemia

Author

Bottomly, Daniel, primary, Long, Nicola, additional, Schultz, Anna Reister, additional, Kurtz, Stephen E., additional, Tognon, Cristina E., additional, Johnson, Kara, additional, Abel, Melissa, additional, Agarwal, Anupriya, additional, Avaylon, Sammantha, additional, Benton, Erik, additional, Blucher, Aurora, additional, Borate, Uma, additional, Braun, Theodore P., additional, Brown, Jordana, additional, Bryant, Jade, additional, Burke, Russell, additional, Carlos, Amy, additional, Chang, Bill H., additional, Cho, Hyun Jun, additional, Christy, Stephen, additional, Coblentz, Cody, additional, Cohen, Aaron M., additional, d’Almeida, Amanda, additional, Cook, Rachel, additional, Danilov, Alexey, additional, Dao, Kim-Hien T., additional, Degnin, Michie, additional, Dibb, James, additional, Eide, Christopher A., additional, English, Isabel, additional, Hagler, Stuart, additional, Harrelson, Heath, additional, Henson, Rachel, additional, Ho, Hibery, additional, Joshi, Sunil K., additional, Junio, Brian, additional, Kaempf, Andy, additional, Kosaka, Yoko, additional, Laderas, Ted, additional, Lawhead, Matt, additional, Lee, Hyunjung, additional, Leonard, Jessica T., additional, Lin, Chenwei, additional, Lind, Evan F., additional, Liu, Selina Qiuying, additional, Lo, Pierrette, additional, Loriaux, Marc M., additional, Luty, Samuel, additional, Maxson, Julia E., additional, Macey, Tara, additional, Martinez, Jacqueline, additional, Minnier, Jessica, additional, Monteblanco, Andrea, additional, Mori, Motomi, additional, Morrow, Quinlan, additional, Nelson, Dylan, additional, Ramsdill, Justin, additional, Rofelty, Angela, additional, Rogers, Alexandra, additional, Romine, Kyle A., additional, Ryabinin, Peter, additional, Saultz, Jennifer N., additional, Sampson, David A., additional, Savage, Samantha L., additional, Schuff, Robert, additional, Searles, Robert, additional, Smith, Rebecca L., additional, Spurgeon, Stephen E., additional, Sweeney, Tyler, additional, Swords, Ronan T., additional, Thapa, Aashis, additional, Thiel-Klare, Karina, additional, Traer, Elie, additional, Wagner, Jake, additional, Wilmot, Beth, additional, Wolf, Joelle, additional, Wu, Guanming, additional, Yates, Amy, additional, Zhang, Haijiao, additional, Cogle, Christopher R., additional, Collins, Robert H., additional, Deininger, Michael W., additional, Hourigan, Christopher S., additional, Jordan, Craig T., additional, Lin, Tara L., additional, Martinez, Micaela E., additional, Pallapati, Rachel R., additional, Pollyea, Daniel A., additional, Pomicter, Anthony D., additional, Watts, Justin M., additional, Weir, Scott J., additional, Druker, Brian J., additional, McWeeney, Shannon K., additional, and Tyner, Jeffrey W., additional

Published
2022
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43. CDK12/13 dual inhibitors are potential therapeutics for acute myeloid leukemia.

Author

Savoy, Lindsey, Long, Nicola, Lee, Hyunjung, Chen, Reid, Allen, Basil, Lin, Hsin‐Yun, Tognon, Cristina, V. Malhotra, Sanjay, Tyner, Jeffrey W., and Zhang, Haijiao

Subjects
*ACUTE myeloid leukemia, *THERAPEUTICS, *GENE expression, *DNA repair, *OVARIAN cancer, *PROTEIN kinases, *CYCLIN-dependent kinases, *SERINE/THREONINE kinases, *PROSTATE cancer
Abstract

Interestingly, THZ531 area under the curve (AUC) values exhibited a strong negative correlation with Venetoclax (Figure 1C), suggesting that CDK12/CDK13 inhibitors may be effective in the cases refractory/resistant to Venetoclax-based treatments. Strikingly, THZ531 and SR-4835 were sensitive in all three samples tested (Figure 1F), further validating that CDK12/CDK13 inhibitors can overcome Venetoclax resistance. The presented data highlights the contrasting sensitivities of THZ531 and Venetoclax in leukaemia samples and proposes the potential of THZ531 to overcome drug resistance associated with Venetoclax-based therapy. [Extracted from the article]

Published
2023
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44. Disruption of the MYC Super-Enhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia

Author

Yashar, William M., primary, Curtiss, Brittany M., additional, Coleman, Daniel J., additional, Van-Campen, Jake, additional, Kong, Garth, additional, Macaraeg, Jommel, additional, Estabrook, Joseph, additional, Demir, Emek, additional, Long, Nicola, additional, Bottomly, Dan, additional, McWeeney, Shannon K., additional, Tyner, Jeffrey W., additional, Druker, Brian J., additional, Maxson, Julia E., additional, and Braun, Theodore P., additional

Published
2022
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48. Acute Myeloid Leukemia Differentiation State and Genotype Influence Anti-Apoptotic Protein Expression, Venetoclax Sensitivity, and Survival in AML

Author

Lachowiez, Curtis A., Eide, Christopher A., Kurtz, Stephen E., Long, Nicola, Rai, Manoj, Xie, Wei, Kaempf, Andy, Bottomly, Daniel, Cook, Rachel, Meyers, Gabrielle, Gandhi, Arpita, Leonard, Jessica T., Hayes-Lattin, Brandon, Newell, Laura F., Maziarz, Richard T, Saultz, Jennifer N., Traer, Elie, Braun, Theodore P, Swords, Ronan T., McWeeney, Shannon K, and Tyner, Jeffrey W

Published
2023
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