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23. Programmability of dual-color DNA-templated silver nanoclusters for modular design of FRET aptasensors toward multiplexed detection.

Author

Hussain, Mustafa, Liu, Yue, Wang, Chengquan, Yang, Huiyuan, Ettayri, Kawtar, Chen, Yu, Wang, Kun, Long, Lingliang, and Qian, Jing

Subjects
MODULAR design, FLUORESCENT probes, APTAMERS, SILVER, DNA
Abstract

By exploiting the programmability of DNA, dual-color DNA-templated silver nanoclusters have been synthesized to serve as a label-free fluorescent probe with a G5-linker at the 3′ end. This advancement facilitates the modular design of universal FRET-based aptasensors using aptamers with a C5-linker at the 3′ end for multiplexed detection, making them easily switch their applications. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Ultrastable NAC-Capped CdZnTe Quantum Dots Encapsulated within Dendritic Mesoporous Silica As an Exceptional Tag for Anti-Interference Fluorescence Aptasensor with Signal Amplification

Author

Yang, Huiyuan, Liu, Yue, Wang, Chengquan, Hussain, Mustafa, Ettayri, Kawtar, Chen, Yu, Wang, Kun, Long, Lingliang, and Qian, Jing

Abstract

In this work, we explored the potential of thiol-capped CdZnTe quantum dots (QDs) as an exceptional signal tag for fluorescence aptasensing applications. Employing a one-pot hydrothermal approach, we modulated the terminal functional groups of CdZnTe QDs using l-cysteine (Lcys), 3-mercaptopropionic acid (MPA), and N-acetyl-l-cysteine (NAC) as ligands. Our comparative analysis revealed that NAC-capped CdZnTe QDs (NAC-CdZnTe QDs) exhibited superior anti-interference capabilities and storage stability across various temperatures, pH levels, and storage durations. Encouraged by these promising results, we further optimized the use of ultrastable NAC-CdZnTe QDs encapsulated in dendritic mesoporous silica nanoparticles (DMSN@QDs) as an exceptional tag for the development of an advanced anti-interference fluorescence aptasensor for aflatoxin B1 (AFB1) detection. The developed aptasensor using DMSN@QDs as signal tags achieved a remarkable signal amplification of approximately 10.2 fold compared to the NAC-CdZnTe QDs coated silica (SiO2@QDs) labeled fluorescence aptasensor. This aptasensor was able to detect AFB1 within a wide range of 1 pg mL–1to 200 ng mL–1, achieving a limit of detection as low as 0.41 pg mL–1(S/N = 3). Crucially, the specific binding affinity between the aptamer and the target enabled the aptasensor to be easily customized for various targets by simply replacing the aptamer sequence with the desired one. The exceptional potential of NAC-CdZnTe QDs, particularly when encapsulated in DMSNs, leads to the development of highly sensitive and selective anti-interference fluorescence aptasensors for various targets, thereby, paving the way for advancements in a diverse range of applications.

Published
2024
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46. Double layer 3D codes: fluorescent supramolecular polymeric gels allowing direct recognition of the chloride anion using a smart phone† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03463j

Author

Ji, Xiaofan, Chen, Wei, Long, Lingliang, Huang, Feihe, and Sessler, Jonathan L.

Subjects
Chemistry
Abstract

The top layer of a two-layer 3D code can be delaminated and removed by exposure to a chloride anion source., Reported here is a two-layer gel construct that permits the on-site detection of the chloride anion by means of a hand-held UV-vis lamp and a smart phone “app”. To prepare this system, eight fluorescent polymeric gels G1–G8 were synthesized. Gels G1–G4 containing C4P/imidazolium-F– anion recognition motifs were used to construct a fluorescent pattern (Code A) that may be read out by a smart phone as a 3D color code (Info A). Gels G5–G8, which are based on C4P/imidazolium-Br– anion interactions, were used to construct an array (Code B) that may be read as Info B. Code B was then adhered to the surface of Code A to produce an adhered double layer code system stabilized by interfacial C4P/imidazolium-Br– anion interactions. Readout of the top layer (Code B) could be achieved without interference from Code A. Treatment with a Cl– anion source was found to delaminate the top layer and leave intact the more robust bottom layer, allowing the bottom layer (Code A) to be read out. The disparate information content associated with Codes A and B thus permits the on-site recognition of Cl–. The present sensing strategy does not rely on elaborate instrumentation and could provide a new application for elaborated soft materials.

Published
2018

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