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Herpes simplex virus encephalitis （HSE）， also known as acute necrotizing encephalitis， is an inflammation of brain parenchyma caused by herpes virus infection. CT perfusion （CTP） imaging， can quickly display abnormal brain tissue perfusion and brain tissue damage， which is commonly used for the diagnosis of stroke. Use of CTP in the auxiliary diagnosis of encephalitis has been rarely reported. Here，a 59-year-old male case of HSE-1 encephalitis diagnosed by CTP was reported. The patient had acute onset of right limb twitching complicated with fever， and mental symptoms. He failed to cooperate with MRI. Therefore， CTP was performed urgently. The results showed that the perfusion of the left temporal lobe was higher than that of the right side. The diagnosis of viral encephalitis could not be excluded. Therefore， acyclovir was pumped for antiviral therapy and other symptomatic treatment was delivered within 12 h after admission， and the conditions were gradually improved. At 3 d after admission， the diagnosis of HSE-1 encephalitis was confirmed by the next-generation sequencing of cerebrospinal fluid pathogens.

Survivors of ischemic stroke are still at a significant risk for recurrence. Antiplatelet agents are the treatment of first choice for long-term secondary prevention of vascular events. This study aims to assess a health promotion program on medication adherence to antiplatelet therapy among ischemic stroke patients in Hainan province, China. In five hospitals from the intervention group, four highly experienced physicians trained 62 neurologists, who in turn trained 613 stroke patients to improve their awareness and adherence to antiplatelet therapy. Physicians and patients of the control group received usual stroke management programs. After one-year follow-up, the proportion of patients who took the antiplatelet therapy increased significantly in the intervention group, reaching 73.2%, with a pre-post difference between two arms of 22.9% ( P < 0.01). There was also a significant net increase in the proportion of patients with awareness of antiplatelet therapy (24.4%, P < 0.01). Multivariate analysis illustrated health promotion program, higher education, annual household income, insurance, and medical status affected antiplatelet drug use in stroke patients. In conclusion, the health promotion program, based on a train-the-trainer approach, showed positive effects on awareness of and adherence to antiplatelet therapy, which has the potential to be scaled up to other resource-limited areas. [ABSTRACT FROM AUTHOR]