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Your search keyword '"London, N.J."' showing total 27 results
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27 results on '"London, N.J."'

11. Endovascular abdominal aortic aneurysm repair

Author

Norwood, M.G.A., Lloyd, G.M., Bown, M.J., Fishwick, G., London, N.J., and Sayers, R.D.

Subjects
Abdominal aneurysm -- Research, Abdominal aneurysm -- Diagnosis, Abdominal aneurysm -- Care and treatment, Outcome and process assessment (Health Care) -- Evaluation, Mortality -- Research, Health
Published
2007

20. P38

Author

Yeluri, S., primary, Muthukumar, N., additional, and London, N.J., additional

Published
2007
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22. Moynihan 05

Author

Payne, D.A., primary, Hayes, P.D., additional, Jones, C.I., additional, Goodall, A.H., additional, Thompson, M.T., additional, London, N.J., additional, Bell, P.R.F., additional, and Naylor, A.R., additional

Published
2002
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25. Clopidogrel reduces thromboembolism after carotid endarterectomy: a randomized trial.

Author

Payne, D.A, Hayes, P.D, Jones, C.I, Goodall, A.H, Thompson, M.T, London, N.J, Bell, P.R.F, and Naylor, A.R

Subjects
ADENOSINE diphosphate, THROMBOEMBOLISM prevention, ENDARTERECTOMY
Abstract

Aims: Postoperative thromboembolic stroke affects 2–3 per cent of patients undergoing carotid endarterectomy (CEA) and is preceded by 1–2 h of increasing embolization. The hypothesis underlying the current study was that preoperative administration of a platelet ADP antagonist (clopidogrel) would reduce embolization and was based on previous studies showing that the platelets of patients with the highest rates of postoperative embolization had increased platelet reactivity to ADP. Methods: Total 100 CEA patients on routine aspirin therapy (75 mg) with an accessible TCD window were randomized to 75 mg clopidogrel (n = 47) or placebo (n = 53) the night before surgery. Platelet function was assessed by flow cytometry. The number of emboli detected by transcranial Doppler within 3 h of CEA was independently quantified. Time taken from restoration of flow to skin closure was used as an indirect measure of the time to secure haemostasis. Results: Clopidogrel significantly reduced platelet activation in response to ADP (P < 0.05) whilst conferring a fourfold reduction in the number of patients with >10 emboli in the postoperative period (OR 4.4, 95 per cent CI: 1.4–14.4; P < 0.008). However, the time from flow restoration to skin closure was >40 min in 30 per cent of clopidogrel patients compared with 8 per cent of controls (P < 0.004). Conclusions: This is the first study to show that a CEA patient's postoperative thromboembolic potential can be significantly reduced by preoperative pharmacotherapy. It remains to be seen whether a lower dose of clopidogrel will confer a similar reduction in embolization whilst reducing the time to achieve haemostasis. [ABSTRACT FROM AUTHOR]

Published
2002
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