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Pregnancy is associated with multiple physiological changes; vascular, endocrine, metabolic and immunological, that can lead to a wide variety of dermatological manifestations. These manifestations can be classified into physiological of pregnancy, exacerbated dermatoses during pregnancy and dermatoses specific to pregnancy or the immediate puerperium. Over the years, the classifications have changed considerably due to the polymorphism of the lesions, but criteria such as the time of onset of the lesions, the presence of maternal fetal risk, and histopathological or immunofluorescence findings have made it possible to simplify the classification. It is very important to recognize and treat early those dermatoses related to maternalfetal risk, that is why we will describe them below, dividing them into dermatoses of pregnancy associated and not associated with fetal compromise and physiological changes in skin and appendages of pregnancy. [ABSTRACT FROM AUTHOR]

The incidence of malignant skin neoplasms of the head and neck has been increasing in recent years, since many of these will require surgical management, dermatologists should be familiar with facial reconstruction techniques using skin flaps. The V-Y flap is a type of advancement flap, its purpose is to replace a rectangular defect by executing a triangular island adjacent to the defect while maintaining established measures to conserve the vascular supply. Finally, a secondary V-shaped defect is formed that will close forming a Y-shape, hence its name "V-Y flap". Knowledge of this technique is useful for facial reconstruction since it allows to achieve oncological, functional, and aesthetic criteria. The objective of this article is to discuss the different uses of the V-Y flap and its variants for the reconstruction of localized defects in the lips, cheeks, and nose. [ABSTRACT FROM AUTHOR]

BACKGROUND: Immune checkpoint inhibitors represent therapies through which it has been possible to significantly impact on the survival of patients with different malignancies such as metastatic melanoma. However, these drugs are associated with adverse events, which are mostly immune-related and can affect any organ, mainly the skin. Most patients present with mild reactions, but occasionally severe adverse events occur, leading to suspension of immunotherapy. CLINICAL CASE: A 37-year-old female patient with stage IIIC melanoma under adjuvant treatment with nivolumab, who developed immune-mediated adverse reactions, including exacerbation of her underlying psoriasis, leading to definitive suspension of this therapy. CONCLUSIONS: It is important to know the adverse effects of prescribed drugs and paying special attention to those patients with a history of immune diseases, since they are at greater risk of presenting these reactions. [ABSTRACT FROM AUTHOR]

BACKGROUND: Vitiligo is the main worldwide acquired skin depigmentation disorder and although it does not cause direct physical discomfort, its presence can be psychologically distressing in patients who suffer from it, affecting their quality of life. OBJECTIVE: To evaluate the quality of life of adult patients with vitiligo from a dermatological Colombian center of reference. MATERIAL AND METHOD: A cross-sectional study with analytical intent was carried out from June to December 2018 at the IPS CES Sabaneta dermatology center, Colombia, where adult patients with vitiligo were included. All patients answered the DLQI and VitiQoL questionnaires to assess quality of life. RESULTS: One hundred and ten patients older than 18 years with vitiligo were evaluated, 56.4% (62) women and 43.6% (48) men, with an average age of 46 ± 12.8 years. 71% (79%) of the patients obtained slight scores in the DLQI and the average of VitiQoL was 31.29 ± 23, with a higher score in the questions of behavior sphere (mean 3.96). According to the VitiQoL, the patients with high school and university education showed a minor alteration of the quality of life with a coefficient of -14.88 and -16.17, respectively (p < 0.018 and 0.031, respectively). CONCLUSION: The affectation of the quality of life in our patients with vitiligo was slight with greater alteration in the sphere of behavior and with less impact in those who have secondary and higher levels of schooling. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To provide evidence in local practice conditions about the adherence and quality of life of patients with hidradenitis suppurativa under biological therapy. MATERIALS AND METHODS: A descriptive observational study was carried out evaluating the records of patients with hidradenitis suppurativa treated with biological therapy between 2019-2020 from a dermatological center in the city of Medellin, Colombia. Sociodemographic and clinical variables were analyzed as well as the association between adherence and changes in quality of life. RESULTS: A total of 83 patients (51 women and 32 men) with a mean age of 32 years were studied. The armpits and groin were the most affected areas; 35% were classified as Hurley III, 33% as Hurley II, and only 11% as Hurley I; 9.6% had a diagnosis of depression and 7.3% were taking antidepressant medications for other reasons; 67.8% were adherent and 18.8% were not. Factors related to greater adherence were female gender, single or separated patients, and groin involvement. The relationship between Hurley classification and adherence was inversely proportional with a p value of 0.092. CONCLUSIONS: This study shows a tendency for patients with adherence problems to have a greater affectation in the quality of life given by the Dermatology Life Quality Index (DLQI). [ABSTRACT FROM AUTHOR]