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1. Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial

Author

Conen, David, Devereaux, PJ, Vincent, Jessica, Wang, Michael Ke, Wells, Jennifer R., Healey, Jeff S., Landoni, Giovanni, McIntyre, William F., Popova, Ekaterine, Sessler, Daniel I., Srinathan, Sadeesh K., Amir, Mohammed, Bangdiwala, Shrikant I., Bossard, Matthias, Chan, Matthew TV, Eikelboom, John W., Fleischmann, Edith, Jolly, Sanjit, Montes, Felix Ramón, Reimer, Cara, Schmartz, Denis, Wang, Chew Yin, Ofori, Sandra N., Blum, Steffen, Alvarez-Garcia, Jesus, Lo Bianco, Giuliana, Traquair, Hugh, Guerrero-Pinedo, Fernando Andres, Oleynick, Christopher, Meyre, Pascal B., Méndez-Zurita, Francisco, Chiarella-Redfern, Helene, Marcucci, Maura, Donati, Francesco, Gonzalez-Osuna, Aranzazu, Minervini, Fabrizio, Moreno Weidmann, Zoraida, Guerra-Ramos, Jose M., Dion, Gabriel, Ramos-Pachón, Anna, Borges, Flavia K., de Sa Boasquevisque, Danielle, Mosconi, Maria Giulia, Amarenco, Pierre, Mitchell, L. Brent, Wyse, George, Cheng, Davy, McAlister, Finlay A., Wells, George A., Baskaran, Geethan, Burns, Andrew T., Gennaccaro, Julia, Howe, Rosemary, Mastrangelo, Louise, Pettit, Shirley, Popovic, Michelle, Shahbaz, Subana, Tosh, Makayla, Zucchetto, Simona J., Heenan, Laura, Lee, Shun Fu, Li, Zhuoru, Xu, Lizhen, Kabon, Barbara, Hoetzenecker, Konrad, Schweiger, Thomas, Reiterer, Christian, Zotti, Oliver, Bsuchner, Paul, Hochreiter, Beatrix, Taschner, Alexander, Adamowitsch, Nikolas, Horvath, Katharina, Hantáková, Nicole, Bidgoli, Javad, Huybrechts, Isabelle, Cappeliez, Serge, Neary, John D., Shargall, Yaron, Tandon, Vikas, Finley, Christian, Agzarian, John, Hanna, Waël, Abdulrahman, Muammar, Lawrence, Kelly, Gregus, Krysten, Quraishi, Faraaz, Wikkerink, Spencer, Wallace, Christine, Prine, Merissa, Gregus, Emily, Hare, Jacqueline, Lombardo, Kristen, Fezia, Behashta, Columbus, Teresa, Rushton, Jacob, DuMerton, Deborah, Reid, Ken, Parlow, Joel, Chung, Wiley, Karizhenskaia, Maria, Malik, Aftab, Tanzola, Rob, Giles, Andrew, McLean, Sean R., McGuire, Anna, Lohser, Jens, Lim, Shirley, Grey, Rebecca, Yee, John, Grant, Kyle, Lee, Alex L., Choi, James J., Dewar, Leith R., Durkin, Christopher, Schisler, Travis, Hecht, Patrick, Hughes, Bevan, Kidane, Biniam, Liu, Richard, Tan, Lawrence, Gowing, Stephen, Buduhan, Gordon, Enns, Stephanie, Poole, Emma, Graham, Kristin, Dubik, Niina, Chin, Alex, Maziak, Donna E., Seely, Andrew JE, Gilbert, Sebastien, Villeneuve, P. James, Sundaresan, Sudhir, Gingrich, Molly, Fazekas, Anna, Bucciero, Kirby, Malthaner, Richard A., Lewis, Deb, Fortin, Dalilah, Qiabi, Mehdi, Nayak, Rahul, Plourde, Madelaine Marie, Haider, Tehmina, Murphy, Rowan, Sellers, Daniel, Donahoe, Laura, Lefebvre, Marco, Lanthier, Luc, Ko, Michael Augustine, Parente, David, Cheung, Victoria, Schieman, Colin, Bessissow, Amal, Wong, Randolph HL, Joynt, Gavin M., Lam, Carmen KM, Lau, Rainbow WH, Wan, Innes YP, Underwood, Malcolm J., Wu, William KK, Wong, Wai Tat, Choi, Gordon YS, Lee, Eva, Hui, Ka Yan, Fung, Beaker, Chan, Chee Sam, Ng, Fung Kei, Thung, Kin Hoi, Gutiérrez-Soriano, Laura, Castañeda, Laura Carmenza, Téllez, Luis Jaime, Ortiz-Ramirez, Lina Marcela, Baiardo-Redaelli, Martina, Belletti, Alessandro, Dieci, Elisa, Monaco, Fabrizio, Muriana, Piergiorgio, Nakhnoukh, Cristina, Novellis, Pierluigi, Turi, Stefano, Viscardi, Stefano, Veronesi, Giulia, Voltolini, Luca, Bongiolatti, Stefano, Salvicchi, Alberto, Gatteschi, Lavinia, Indino, Rossella, Tombelli, Simone, Ravasin, Alice, Salimbene, Ottavia, Rosboch, Giulio Luca, Balzani, Eleonora, Ceraolo, Edoardo, Neitzert, Luca, Brazzi, Luca, Londero, Francesco, Grossi, William, Massullo, Domenico, Fiorelli, Silvia, Margaritora, Stefano, Hashim, Shahrul Amry, Krishnasamy, Sivakumar, See, Woan Shiang, Nawaz, Mohammed Asghar, Bilal, Haris, Trujillo Reyes, Juan Carlos, Martínez-Téllez, Elisabeth, Belda Sanchis, Josep, Planas Canovas, Georgina, Libreros Niño, Alejandra, Parera Ruiz, Ana, Cladellas Gutierrez, Esther, Guarino, Mauro, Urrutia Cuchi, Gerard, Argilaga Nogues, Marta, Rovira Juan, Anna, Medina-Aedo, Melixa, Turró Castillejo, Mª Asunción, Gil Sanchez, Josep Mª, Araúz-Sarmiento, Ibell, Herranz Perez, Gracia, Chavarria Murillo, Stephania, Garcia-Osuna, Alvaro, Rodriguez-Arias, Ainhoa, Berga Garrote, Nuria, Martín Grande, Ascension, Parise Roux, Diego, Gajate Martín, Luis, De Pablo Pajares, Angélica, Candela Toha, Angel Manuel, Moreno Mata, Nicolás, Muñoz Molina, Gema, Caballero Silva, Usue, Cabañero, Alberto, Fra Fernandez, Sara, Cavestany García-Matres, Cristina, Simón, Luisa, Montenegro, Cristina, Pozo, Sergio, Gonzàlez-Tallada, Anna, González Suarez, Susana, Ribas Ball, Montserrat, De Nadal Clanchet, Miriam, Pérez Vélez, Javier, Cruz, Patrícia, Sánchez-Pedrosa, Guillermo, Duque, Patricia, González, Guillermo, Huerta, Luis, Rodríguez, Laura, Garutti, Ignacio, Ruiz-Villa, Laura, Martí-Ejarque, Maria del Mar, Gili-Bueno, Mireia, Maddio Vieyra, Ricardo Matias, Fibla, Juan J., Durán, Núria, de Temple Pla, Marina, Rodríguez-Fuster, Alberto, Bermejo-Martínez, Silvia, Carramiñana, Albert, Opitz, Isabelle, Etienne, Harry, Cata, Juan P., Guerra-Londono, Juan Jose, Rajaram, Ravi, Corrales, German, Vaporciyan, Ara, Mehran, Reza, Sepesi, Boris, Walsh, Garrett, Rice, David, Cukierman, Daniel S., Swisher, Stephen, Marchant, Bryan E., Harris, Lynne C., Cusson, Bruce D., Miller, Scott A., Ayad, Sabry, Araujo, Jorge, Marquez-Roa, Leonardo, Hofstra, Richard L., Wudel, Jr., Leonard J., Minear, Steven C., Teixeira, Camila, Pimentel, Mario, Popoff, Andrew M., Marsack, Kelly, Meehan, Sarah, Chen, Tzonghuei H., Essandoh, Michael, Poppers, Jeremy S., Ke Wang, Michael, Chan, Matthew T V, Cata, Juan P, McLean, Sean R, Srinathan, Sadeesh K, Reyes, Juan Carlos Trujillo, Grande, Ascension Martín, Tallada, Anna Gonzalez, Sessler, Daniel I, Maziak, Donna E, McIntyre, William F, Wong, Randolph H L, McGuire, Anna L, Roux, Diego Parise, Wells, Jennifer R, Ofori, Sandra N, Eikelboom, John W, Jolly, Sanjit S, Healey, Jeff S, and Devereaux, P J

Published
2023
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2. Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial

Author

Devereaux, Vincent, Jessica, Wang, Michael Ke, Wells, Jennifer R., Conen, David, Devereaux, PJ, Healey, Jeff S., Landoni, Giovanni, McIntyre, William F., Popova, Ekaterine, Sessler, Daniel I., Srinathan, Sadeesh K., Amir, Mohammed, Bangdiwala, Shrikant I., Bossard, Matthias, Chan, Matthew T.V., Eikelboom, John W., Fleischmann, Edith, Jolly, Sanjit S., Montes, Felix Ramón, Reimer, Cara, Schmartz, Denis, Wang, Chew Yin, Alvarez-Garcia, Jesus, Bianco, Giuliana Lo, Blum, Steffen, Boasquevisque, Danielle de Sa, Borges, Flavia K., Chiarella-Redfern, Helene, Gonzalez-Osuna, Aranzazu, Guerra-Ramos, Jose M., Marcucci, Maura, Meyre, Pascal B., Ofori, Sandra N., Oleynick, Christopher, Ramos-Pachón, Anna, Traquair, Hugh, Mitchell, L. Brent, Wyse, George, Cheng, Davy, McAlister, Finlay A., Wells, George A., Baskaran, Geethan, Gennaccaro, Julia, Howe, Rosemary, Mastrangelo, Louise, Pettit, Shirley, Shahbaz, Subana, Tosh, Makayla, Zucchetto, Simona J., Heenan, Laura, Lee, Shun Fu, Li, Zhuoru, Xu, Lizhen, Kabon, Barbara, Reiterer, Christian, Taschner, Alexander, Horvath, Katharina, Adamowitsch, Nikolas, Zotti, Oliver, Hantáková, Nicole, Hochreiter, Beatrix, Huybrechts, Isabelle, Cappeliez, Serge, Neary, John D., Shargall, Yaron, Tandon, Vikas, Finley, Christian, Agzarian, John, Hanna, Waël, Abdulrahman, Muammar, Lawrence, Kelly, Gregus, Krysten, Quraishi, Faraaz, Wikkerink, Spencer, Wallace, Christine, Prine, Merissa, Gregus, Emily, Hare, Jacqueline, Lombardo, Kristen, Fezia, Behashta, Columbus, Teresa, DuMerton, Deborah, Reid, Ken, Parlow, Joel, Chung, Wiley, Karizhenskaia, Maria, Malik, Aftab, Kidane, Biniam, Liu, Richard, Tan, Lawrence, Gowing, Stephen, Buduhan, Gordon, Enns, Stephanie, Poole, Emma, Graham, Kristin, McLean, Sean R., McGuire, Anna, Lohser, Jens, Lim, Shirley, Grey, Rebecca, Grant, Kyle, Lee, Alex L., Choi, James J., Dewar, Leith R., Yee, John, Maziak, Donna E., Seely, Andrew J.E., Gilbert, Sebastien, Villeneuve, P. James, Sundaresan, Sudhir, Moffatt-Bruce, Susan D., Gingrich, Molly, Fazekas, Anna, Bucciero, Kirby, Malthaner, Richard A., Lewis, Deb, Fortin, Dalilah, Qiabi, Mehdi, Nayak, Rahul, Plourde, Madelaine Marie, Sellers, Daniel, Donahoe, Laura, Lefebvre, Marco, Lanthier, Luc, Schieman, Colin, Bessissow, Amal, Joynt, Gavin M., Wong, Randolph H.L., Lau, Rainbow W.H., Wong, Wai Tat, Choi, Gordon Y.S., Lee, Eva, Hui, Ka Yan, Fung, Beaker, Chan, Chee Sam, Gutiérrez-Soriano, Laura, Castañeda, Laura Carmenza, Téllez, Luis Jaime, Ortiz-Ramirez, Lina Marcela, De Santis, Simona, Favaro, Giovanni, Muriana, Piergiorgio, Nakhnoukh, Cristina, Novellis, Pierluigi, Turi, Stefano, Veronesi, Giulia, Angelini, Matteo, Voltolini, Luca, Bongiolatti, Stefano, Salvicchi, Alberto, Gatteschi, Lavinia, Indino, Rossella, Tombelli, Simone, Ravasin, Alice, Salimbene, Ottavia, Rosboch, Giulio Luca, Balzani, Eleonora, Massullo, Domenico, Fiorelli, Silvia, Londero, Francesco, Grossi, William, Ng, Tyng Yan, See, Woan Shiang, Nawaz, Mohammed Asghar, Reyes, Juan Carlos Trujillo, Tellez, Elisabeth Martinez, Sanchis, Josep Belda, Cánovas, Georgina Planas, Ruiz, Ana Parera, Gutierrez, Esther Cladellas, Guarino, Mauro, Cuchi, Gerard Urrutia, Nogues, Marta Argilaga, Juan, Anna Rovira, Medina-Aedo, Melixa, Grande, Ascensión Martín, Roux, Diego Parise, Martín, Luis Gajate, Pajares, Angélica De Pablo, Toha, Angel Manuel Candela, Mata, Nicolás Moreno, Molina, Gema Muñoz, Silva, Usue Caballero, Cabañero, Alberto, Fernandez, Sara Fra, Tallada, Anna Gonzàlez, Suarez, Susana González, Ball, Montserrat Ribas, Clanchet, Miriam De Nadal, Ruiz-Villa, Laura, Martí-Ejarque, M.M., Gili-Bueno, Mireia, Ferrández, Jorge Hernández, Llobet, Neus Pons, Cruz, Patricia, Sánchez-Pedrosa, Guillermo, Duque, Patricia, Azcárate, Leire, Martín-Albo, Lorena, Rodríguez-Fuster, Alberto, Bermejo-Martínez, Silvia, Carramiñana, Albert, Minervini, Fabrizio, Cata, Juan P., Rajaram, Ravi, Corrales, German, Guerra-Londono, Juan Jose, Mehran, Reza, Sepesi, Boris, Walsh, Garrett, Cukierman, Daniel S., Marchant, Bryan E., Harris, Lynne C., Cusson, Bruce D., Miller, Scott A., Minear, Steven C., Teixeira, Camila, Pimentel, Mario, Popoff, Andrew M., Cheung, Wing Lee, Marsack, Kelly, Ayad, Sabry, Araujo, Jorge, Chen, Tzonghuei H., Essandoh, Michael, Poppers, Jeremy S., Trujillo Reyes, Juan Carlos, Gonzalez Tallada, Anna, and Garg, Amit X.

Published
2023
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3. The Overweight Paradox: Impact of Body Mass Index on Patients Undergoing VATS Lobectomy or Segmentectomy

Author

Parini, Sara, Azzolina, Danila, Massera, Fabio, Mastromarino, Maria Giovanna, Papalia, Esther, Baietto, Guido, Curcio, Carlo, Crisci, Roberto, Rena, Ottavio, Alloisio, Marco, Amore, Dario, Ampollini, Luca, Ardò, Nicoletta, Argnani, Desideria, Baisi, Alessandro, Bandiera, Alessandro, Benato, Cristiano, Benvenuti, Mauro Roberto, Bertani, Alessandro, Bortolotti, Luigi, Bottoni, Edoardo, Breda, Cristiano, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Carleo, Francesco, Cavallesco, Giorgio, Cherchi, Roberto, De Palma, Angela, Dell'Amore, Andrea, Della Beffa, Vittorio, Divisi, Duilio, Dolci, Giampiero, Droghetti, Andrea, Ferrari, Paolo, Fontana, Diego, Gasparri, Roberto, Gavezzoli, Diego, Ghisalberti, Marco, Giovanardi, Michele, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Lausi, Paolo, Lo Giudice, Fabio, Londero, Francesco, Lopez, Camillo, Mancuso, Maurizio, Maniscalco, Pio, Margaritora, Stefano, Marulli, Giuseppe, Mazza, Federico, Meacci, Elisa, Melloni, Giulio, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Paladini, Piero, Pariscenti, Gianluca, Perkmann, Reinhold, Pernazza, Fausto, Pirondini, Emanuele, Puma, Francesco, Raveglia, Federico, Refai, Majed, Rinaldo, Alessandro, Risso, Carlo, Rizzardi, Giovanna, Rotolo, Nicola, Scarci, Marco, Solli, Piergiorgio, Sollitto, Francesco, Spaggiari, Lorenzo, Stefani, Alessandro, Stella, Franco, Surrente, Corrado, Tancredi, Giorgia, Terzi, Alberto, Torre, Massimo, Tosi, Davide, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, and Zaraca, Francesco

Published
2023
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4. Post-operative outcomes and quality of life assessment after thoracoscopic lobectomy for Non-small-cell lung cancer in octogenarians: Analysis from a national database

Author

Alloisio, Marco, Amore, Dario, Ampollini, Luca, Andreetti, Claudio, Argnani, Desideria, Baietto, Guido, Bandiera, Alessandro, Benato, Cristiano, Benvenuti, Mauro Roberto, Bertani, Alessandro, Bertolaccini, Luca, Bortolotti, Luigi, Bottoni, Edoardo, Breda, Cristiano, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Casadio, Caterina, Cavallesco, Giorgio, Cherchi, Roberto, Crisci, Roberto, Curcio, Carlo, Dell’Amore, Andrea, Della Beffa, Vittorio, Dolci, Giampiero, Droghetti, Andrea, Ferrari, Paolo A., Fontana, Diego, Gargiulo, Gaetano, Gasparri, Roberto, Gavezzoli, Diego, Ghisalberti, Marco, Giovanardi, Michele, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Iurilli, Luciano, Lausi, Paolo, Lo Giudice, Fabio, Londero, Francesco, Luzzi, Luca, Lopez, Camillo, Mancuso, Maurizio, Maniscalco, Pio, Margaritora, Stefano, Meacci, Elisa, Melloni, Giulio, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Pariscenti, Gianluca, Perkmann, Reinhold, Pernazza, Fausto, Pirondini, Emanuele, Poggi, Camilla, Puma, Francesco, Refai, Majed, Rinaldo, Alessandro, Rizzardi, Giovanna, Rosso, Lorenzo, Rotolo, Nicola, Russo, Emanuele, Sabbatini, Armando, Scarci, Marco, Spaggiari, Lorenzo, Stefani, Alessandro, Solli, Piergiorgio, Surrente, Corrado, Terzi, Alberto, Torre, Massimo, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, Zaccagna, Gino, Zaraca, Francesco, Bongiolatti, Stefano, and Borgianni, Sara

Published
2021
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6. Conversion due to vascular injury during video-assisted thoracic surgery lobectomy: A multicentre retrospective analysis from the Italian video-assisted thoracic surgery group registry

Author

Bertolaccini, Luca, Davoli, Fabio, Pardolesi, Alessandro, Brandolini, Jury, Argnani, Desideria, Bertani, Alessandro, Droghetti, Andrea, Gonfiotti, Alessandro, Divisi, Duilio, Crisci, Roberto, Solli, Piergiorgio, Nosotti, Mario, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, di Rienzo, Gaetano, Lopez, Camillo, Morelli, Angelo, Londero, Francesco, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Andretti, Claudio, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Benvenuti, Mauro Roberto, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, and Guerrera, Francesco

Published
2019
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7. Lung oligometastatic disease: redefining cancer pathogenesis from a surgical perspective

Author

Londero, Francesco, Londero, Francesco, Londero, Francesco, and Londero, Francesco

Abstract

Cancer is one of the leading causes of death worldwide. In more than 90% of cases, patients die as a consequence of development of metastases, the diffusion of cancer cells in distant organs from the primary tumor site. This process, which accounts for the high mortality of patients with this condition, is one of the less understood steps of cancer behaviour. In a minority of cases, metastases occur with a limited pattern, rendering them amenable of surgical resection. The lung is a frequent site of metastases and surgical metastasectomy turns out curative in almost 50% of patients. This thesis investigated many aspects concerning the practice of pulmonary metastasectomy, with a peculiar focus on the relationship between cancer, the nutritional status and the immune function of the patients. Indeed, the practice of metastasectomy offers an ideal model to understand some aspects of cancer pathogenesis.

Published
2022

9. Unexpected Cause of Pericarditis: Chest Teratoma

Author

Negri, Francesco, primary, De Biasio, Marzia, additional, Burelli, Massimo, additional, Favaretto, Virginia, additional, Londero, Francesco, additional, De Pellegrin, Alessandro, additional, Sponza, Massimo, additional, Sinagra, Gianfranco, additional, and Imazio, Massimo, additional

Published
2022
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10. The Overweight Paradox: Impact of Body Mass Index on Patients Undergoing VATS Lobectomy or Segmentectomy

Author

Parini, Sara, primary, Azzolina, Danila, additional, Massera, Fabio, additional, Mastromarino, Maria Giovanna, additional, Papalia, Esther, additional, Baietto, Guido, additional, Curcio, Carlo, additional, Crisci, Roberto, additional, Rena, Ottavio, additional, Alloisio, Marco, additional, Amore, Dario, additional, Ampollini, Luca, additional, Ardò, Nicoletta, additional, Argnani, Desideria, additional, Baisi, Alessandro, additional, Bandiera, Alessandro, additional, Benato, Cristiano, additional, Benvenuti, Mauro Roberto, additional, Bertani, Alessandro, additional, Bortolotti, Luigi, additional, Bottoni, Edoardo, additional, Breda, Cristiano, additional, Camplese, Pierpaolo, additional, Carbognani, Paolo, additional, Cardillo, Giuseppe, additional, Carleo, Francesco, additional, Cavallesco, Giorgio, additional, Cherchi, Roberto, additional, De Palma, Angela, additional, Dell'Amore, Andrea, additional, Della Beffa, Vittorio, additional, Divisi, Duilio, additional, Dolci, Giampiero, additional, Droghetti, Andrea, additional, Ferrari, Paolo, additional, Fontana, Diego, additional, Gasparri, Roberto, additional, Gavezzoli, Diego, additional, Ghisalberti, Marco, additional, Giovanardi, Michele, additional, Gonfiotti, Alessandro, additional, Guerrera, Francesco, additional, Imperatori, Andrea, additional, Infante, Maurizio, additional, Lausi, Paolo, additional, Lo Giudice, Fabio, additional, Londero, Francesco, additional, Lopez, Camillo, additional, Mancuso, Maurizio, additional, Maniscalco, Pio, additional, Margaritora, Stefano, additional, Marulli, Giuseppe, additional, Mazza, Federico, additional, Meacci, Elisa, additional, Melloni, Giulio, additional, Morelli, Angelo, additional, Mucilli, Felice, additional, Natali, Pamela, additional, Negri, Giampiero, additional, Nicotra, Samuele, additional, Nosotti, Mario, additional, Paladini, Piero, additional, Pariscenti, Gianluca, additional, Perkmann, Reinhold, additional, Pernazza, Fausto, additional, Pirondini, Emanuele, additional, Puma, Francesco, additional, Raveglia, Federico, additional, Refai, Majed, additional, Rinaldo, Alessandro, additional, Risso, Carlo, additional, Rizzardi, Giovanna, additional, Rotolo, Nicola, additional, Scarci, Marco, additional, Solli, Piergiorgio, additional, Sollitto, Francesco, additional, Spaggiari, Lorenzo, additional, Stefani, Alessandro, additional, Stella, Franco, additional, Surrente, Corrado, additional, Tancredi, Giorgia, additional, Terzi, Alberto, additional, Torre, Massimo, additional, Tosi, Davide, additional, Vinci, Damiano, additional, Viti, Andrea, additional, Voltolini, Luca, additional, and Zaraca, Francesco, additional

Published
2022
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12. Chemosensitivity of Lung Metastatic High-Grade Synovial Sarcoma

Author

Tetta, Cecilia, primary, Montrone, Grazia, additional, Longhi, Alessandra, additional, Rocca, Michele, additional, Londero, Francesco, additional, Parise, Gianmarco, additional, Parise, Orlando, additional, Maessen, Jos G., additional, Miceli, Marco, additional, and Gelsomino, Sandro, additional

Published
2021
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14. Corrigendum to ‘Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study’

Author

Guerrera, Francesco, primary, Falcoz, Pierre Emmanuel, additional, Moser, Bernhard, additional, van Raemdonck, Dirk, additional, Bille, Andrea, additional, Toker, Alper, additional, Spaggiari, Lorenzo, additional, Ampollini, Luca, additional, Filippini, Claudia, additional, Thomas, Pascal Alexandre, additional, Verdonck, Bram, additional, Mendogni, Paolo, additional, Aigner, Clemens, additional, Voltolini, Luca, additional, Novoa, Nuria, additional, Patella, Miriam, additional, Mantovani, Sara, additional, Bravio, Ivan Gomes, additional, Zisis, Charalambos, additional, Guirao, Angela, additional, Londero, Francesco, additional, Congregado, Miguel, additional, Rocco, Gaetano, additional, Pont, Bert Du, additional, Martucci, Nicola, additional, Esch, Matthias, additional, Brunelli, Alessandro, additional, Detterbeck, Frank C, additional, Venuta, Federico, additional, Weder, Walter, additional, Ruffini, Enrico, additional, Klepetko, Walter, additional, Olland, Anne, additional, DuPont, Bert, additional, Nonaka, Daisuke, additional, Ozkan, Berker, additional, Lo Iacono, Giorgio, additional, Braggio, Cesare, additional, Filosso, Pier Luigi, additional, Brioude, Geoffrey, additional, van Schil, Paul, additional, Nosotti, Mario, additional, Valdivia, Daniel, additional, Bongiolatti, Stefano, additional, Inci, Ilhan, additional, Dimitra, Rontogianni, additional, Sànchez, David, additional, Grossi, William, additional, Moreno-Merino, Sergio, additional, and Teschner, Martin, additional

Published
2021
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15. Post-operative outcomes and quality of life assessment after thoracoscopic lobectomy for Non-small-cell lung cancer in octogenarians: Analysis from a national database

Author

Bongiolatti, Stefano, primary, Gonfiotti, Alessandro, additional, Borgianni, Sara, additional, Crisci, Roberto, additional, Curcio, Carlo, additional, Voltolini, Luca, additional, Alloisio, Marco, additional, Amore, Dario, additional, Ampollini, Luca, additional, Andreetti, Claudio, additional, Argnani, Desideria, additional, Baietto, Guido, additional, Bandiera, Alessandro, additional, Benato, Cristiano, additional, Benvenuti, Mauro Roberto, additional, Bertani, Alessandro, additional, Bertolaccini, Luca, additional, Bortolotti, Luigi, additional, Bottoni, Edoardo, additional, Breda, Cristiano, additional, Camplese, Pierpaolo, additional, Carbognani, Paolo, additional, Cardillo, Giuseppe, additional, Casadio, Caterina, additional, Cavallesco, Giorgio, additional, Cherchi, Roberto, additional, Dell’Amore, Andrea, additional, Della Beffa, Vittorio, additional, Dolci, Giampiero, additional, Droghetti, Andrea, additional, Ferrari, Paolo A., additional, Fontana, Diego, additional, Gargiulo, Gaetano, additional, Gasparri, Roberto, additional, Gavezzoli, Diego, additional, Ghisalberti, Marco, additional, Giovanardi, Michele, additional, Guerrera, Francesco, additional, Imperatori, Andrea, additional, Infante, Maurizio, additional, Iurilli, Luciano, additional, Lausi, Paolo, additional, Lo Giudice, Fabio, additional, Londero, Francesco, additional, Luzzi, Luca, additional, Lopez, Camillo, additional, Mancuso, Maurizio, additional, Maniscalco, Pio, additional, Margaritora, Stefano, additional, Meacci, Elisa, additional, Melloni, Giulio, additional, Morelli, Angelo, additional, Mucilli, Felice, additional, Natali, Pamela, additional, Negri, Giampiero, additional, Nicotra, Samuele, additional, Nosotti, Mario, additional, Pariscenti, Gianluca, additional, Perkmann, Reinhold, additional, Pernazza, Fausto, additional, Pirondini, Emanuele, additional, Poggi, Camilla, additional, Puma, Francesco, additional, Refai, Majed, additional, Rinaldo, Alessandro, additional, Rizzardi, Giovanna, additional, Rosso, Lorenzo, additional, Rotolo, Nicola, additional, Russo, Emanuele, additional, Sabbatini, Armando, additional, Scarci, Marco, additional, Spaggiari, Lorenzo, additional, Stefani, Alessandro, additional, Solli, Piergiorgio, additional, Surrente, Corrado, additional, Terzi, Alberto, additional, Torre, Massimo, additional, Vinci, Damiano, additional, Viti, Andrea, additional, Zaccagna, Gino, additional, and Zaraca, Francesco, additional

Published
2021
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18. Standardized uptake value and radiological density attenuation as predictive and prognostic factors in patients with solitary pulmonary nodules: our experience on 1,592 patients

Author

Divisi, Duilio, Barone, Mirko, Bertolaccini, Luca, Rocco, Gaetano, Solli, Piergiorgio, Crisci, Roberto, Italian Vats Group, Ampollini, Luca, Alloisio, Marco, Andreetti, Claudio, Amore, Dario, Baietto, Guido, Bandiera, Alessandro, Benato, Cristiano, Benetti, Diego, Benvenuti, Mauro, Bertani, Alessandro, Bortolotti, Luigi, Bottoni, Edoardo, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Carleo, Francesco, Casadio, Caterina, Cavallesco, Giorgio, Curcio, Carlo, Denegri, Andrea, Di Rienzo, Gaetano, Dolci, Giampiero, Droghetti, Andrea, Gasparri, Roberto, Ghisalberti, Marco, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Lausi, Paolo, Londero, Francesco, Lopez, Camillo, Luzzi, Luca, Maineri, Paola, Maniscalco, Pio, Marulli, Giuseppe, Monteverde, Marco, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Perkmann, Reinhold, Poggi, Camilla, Puma, Francesco, Refai, Mayed, Rinaldo, Alessandro, Rizzardi, Giovanna, Rosso, Lorenzo, Rotolo, Nicola, Russo, Emanuele, Sabatini, Armando, Spaggiari, Lorenzo, Stefani, Alessandro, Stella, Franco, Terzi, Alberto, Torre, Massimo, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, Zaraca, Francesco, Divisi, Duilio, Barone, Mirko, Bertolaccini, Luca, Rocco, Gaetano, Solli, Piergiorgio, Crisci, Roberto, Italian VATS, Group, Negri, G, Ampollini, Luca, Alloisio, Marco, Andreetti, Claudio, Amore, Dario, Baietto, Guido, Bandiera, Alessandro, Benato, Cristiano, Benetti, Diego, Benvenuti, Mauro, Bertani, Alessandro, Bortolotti, Luigi, Bottoni, Edoardo, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Carleo, Francesco, Casadio, Caterina, Cavallesco, Giorgio, Curcio, Carlo, Denegri, Andrea, Di Rienzo, Gaetano, Dolci, Giampiero, Droghetti, Andrea, Gasparri, Roberto, Ghisalberti, Marco, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Lausi, Paolo, Londero, Francesco, Lopez, Camillo, Luzzi, Luca, Maineri, Paola, Maniscalco, Pio, Marulli, Giuseppe, Monteverde, Marco, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Perkmann, Reinhold, Poggi, Camilla, Puma, Francesco, Refai, Mayed, Rinaldo, Alessandro, Rizzardi, Giovanna, Rosso, Lorenzo, Rotolo, Nicola, Russo, Emanuele, Sabatini, Armando, Spaggiari, Lorenzo, Stefani, Alessandro, Stella, Franco, Terzi, Alberto, Torre, Massimo, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, and Zaraca, Francesco

Subjects
Lung adenocarcinoma, Pulmonary and Respiratory Medicine, medicine.medical_specialty, VATS lobectomy, Standardized uptake value, Malignancy, Ground-glass opacity, NO, 030218 nuclear medicine & medical imaging, Maximum standardized uptake value, 03 medical and health sciences, 0302 clinical medicine, ground glass opacities, Solitary pulmonary nodule (SPN), maximum standardized uptake value, lymph node metastases, lung adenocarcinoma, Lymph node metastase, medicine, Ground glass opacities, Lymph node metastases, Lung cancer, Lymph node, business.industry, Ground glass opacitie, Nodule (medicine), medicine.disease, Primary tumor, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Original Article, Radiology, medicine.symptom, business
Abstract

Background: Multislice computed tomography (MSCT) increased detection of solitary pulmonary nodules (SPNs), changing the management based on radiological and clinical factors. When 18-fluorine fluorodeoxyglucose positron emission tomography combined with computed tomography ( 18 F-FDG-PET/CT) was considered for the evaluation of nodules, the maximum standardized uptake value (SUVmax) more than 2.5 is used frequently as a cut off for malignancy. The purpose of this study is to evaluate SUVmax PET/CT and pulmonary attenuation patterns at MSCT in patients with SPN according to morphological and pathological characteristics of the lesion. Methods: A retrospective study on 1,592 SPN patients was carried out following approval by the Italian Registry of VATS Lobectomies. Results: All patients underwent VATS lobectomy. On histologic examination, 98.1% had primary or second metachronous primary lung cancers. In addition, 10.7% presented occult lymph node metastases (pN1 or pN2) on histological examination. Nodule attenuation on CT was associated with the histology of the lesion (p= 0.030); in particular, pure ground glass opacities (pGGOs) and partially solid nodules were related to adenocarcinomatous histotypes. Conversely, a significant relationship between SUVmax and age, nodule size, pathological node status (pN) was found (P=0.007, P=0.000 and P=0.002 respectively). Conclusions: Nodule attenuation can predict the histology of the lesion whereas SUVmax may relate to the propensity to lymph node metastases.

Published
2017

19. A risk stratification scheme for synchronous oligometastatic non-small cell lung cancer developed by a multicentre analysis

Author

Spaggiari, Lorenzo, primary, Bertolaccini, Luca, additional, Facciolo, Francesco, additional, Gallina, Filippo Tommaso, additional, Rea, Federico, additional, Schiavon, Marco, additional, Margaritora, Stefano, additional, Congedo, Maria Teresa, additional, Lucchi, Marco, additional, Ceccarelli, Ilaria, additional, Alloisio, Marco, additional, Bottoni, Edoardo, additional, Negri, Giampiero, additional, Carretta, Angelo, additional, Cardillo, Giuseppe, additional, Ricciardi, Sara, additional, Ruffini, Enrico, additional, Costardi, Lorena, additional, Muriana, Giovanni, additional, Viggiano, Domenico, additional, Rusca, Michele, additional, Ventura, Luigi, additional, Marulli, Giuseppe, additional, De Palma, Angela, additional, Rosso, Lorenzo, additional, Mendogni, Paolo, additional, Crisci, Roberto, additional, De Vico, Andrea, additional, Maniscalco, Pio, additional, Tamburini, Nicola, additional, Puma, Francesco, additional, Ceccarelli, Silvia, additional, Voltolini, Luca, additional, Bongiolatti, Stefano, additional, Morelli, Angelo, additional, and Londero, Francesco, additional

Published
2021
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22. A Preoperative Risk Classification for Synchronous Oligometastatic Non-Small Cell Lung Cancer

Author

Bertolaccini, Luca, primary, Spaggiari, Lorenzo, additional, Facciolo, Francesco, additional, Gallina, Filippo Tommaso, additional, Rea, Federico, additional, Schiavon, Marco, additional, Margaritora, Stefano, additional, Congedo, Maria Teresa, additional, Lucchi, Marco, additional, Ceccarelli, Ilaria, additional, Alloisio, Marco, additional, Bottoni, Edoardo, additional, Negri, Giampiero, additional, Carretta, Angelo, additional, Cardillo, Giuseppe, additional, Ricciardi, Sara, additional, Ruffini, Enrico, additional, Costardi, Lorena, additional, Muriana, Giovanni, additional, Viggiano, Domenico, additional, Rusca, Michele, additional, Ventura, Luigi, additional, Marulli, Giuseppe, additional, De Palma, Angela, additional, Rosso, Lorenzo, additional, Mendogni, Paolo, additional, Crisci, Roberto, additional, De Vico, Andrea, additional, Maniscalco, Pio, additional, Tamburini, Nicola, additional, Puma, Francesco, additional, Ceccarelli, Silvia, additional, Voltolini, Luca, additional, Bongiolatti, Stefano, additional, Morelli, Angelo, additional, and Londero, Francesco, additional

Published
2021
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24. The Impact of Preoperative Inflammatory Markers on the Prognosis of Patients Undergoing Surgical Resection of Pulmonary Oligometastases

Author

Londero, Francesco, primary, Grossi, William, additional, Parise, Orlando, additional, Cinel, Jacqueline, additional, Parise, Gianmarco, additional, Masullo, Gianluca, additional, Tetta, Cecilia, additional, Micali, Linda Renata, additional, Mauro, Emanuela, additional, Morelli, Angelo, additional, Maessen, Jos G., additional, and Gelsomino, Sandro, additional

Published
2020
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27. Clinical and Radiologic Features Together Better Predict Lung Nodule Malignancy in Patients with Soft-Tissue Sarcoma

Author

Tetta, Cecilia, primary, Giugliano, Antonio, additional, Tonetti, Laura, additional, Rocca, Michele, additional, Longhi, Alessandra, additional, Londero, Francesco, additional, Parise, Gianmarco, additional, Parise, Orlando, additional, Micali, Linda Renata, additional, La Meir, Mark, additional, Maessen, Jos G., additional, and Gelsomino, Sandro, additional

Published
2020
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29. Safety of lymphadenectomy during video-assisted thoracic surgery lobectomy. Analysis from a national database

Author

Gonfiotti, Alessandro, Bertani, Alessandro, Nosotti, Mario, Viggiano, Domenico, Bongiolatti, Stefano, Bertolaccini, Luca, Droghetti, Andrea, Solli, Piergiorgio, Crisci, Roberto, Voltolini, Luca, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, Di Rienzo, Gaetano, Lopez, Camillo, Divisi, Duilio, Morelli, Angelo, Russo, Emanuele, Londero, Francesco, Rosso, Lorenzo, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Giovanardi, Andrea, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Argnani, Desideria, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Ibrahim, Mohsen, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Benvenuti, Mauro Roberto, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, Guerrera, Francesco, Gonfiotti, Alessandro, Bertani, Alessandro, Nosotti, Mario, Viggiano, Domenico, Bongiolatti, Stefano, Bertolaccini, Luca, Droghetti, Andrea, Solli, Piergiorgio, Crisci, Roberto, Voltolini, Luca, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, Di Rienzo, Gaetano, Lopez, Camillo, Divisi, Duilio, Morelli, Angelo, Russo, Emanuele, Londero, Francesco, Rosso, Lorenzo, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Giovanardi, Andrea, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Argnani, Desideria, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Ibrahim, Mohsen, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Benvenuti, Mauro Roberto, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, and Guerrera, Francesco

Subjects
Male, Lung Neoplasms, Time Factors, medicine.medical_treatment, 030204 cardiovascular system & hematology, Logistic regression, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, 80 and over, Prospective Studies, Lobectomy, Lung cancer, Video-assisted thoracic surgery, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Lymph Node Excision, Lymphatic Metastasis, Mediastinum, Middle Aged, Neoplasm Staging, Pneumonectomy, Thoracic Surgery, Video-Assisted, Treatment Outcome, Prospective cohort study, Non-Small-Cell Lung, Thoracic Surgery, General Medicine, medicine.anatomical_structure, Cardiothoracic surgery, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Video-Assisted, NO, 03 medical and health sciences, medicine, Rank correlation, business.industry, Carcinoma, medicine.disease, Surgery, 030228 respiratory system, Lymphadenectomy, business, Lobectomy, Lung cancer, Video-assisted thoracic surgery
Abstract

OBJECTIVES The Italian VATS Group database was accessed to evaluate whether preoperative and intraoperative factors may affect the safety of lymphadenectomy (LA) during video-assisted thoracic surgery lobectomy. METHODS All video-assisted thoracic surgery lobectomy procedures performed between 1 January 2014 and 30 March 2017 for non-small-cell lung cancer with cN0 or cN1 disease were identified in the database. LA safety was evaluated based on intraoperative (operative time, bleeding and conversion rate) and postoperative (30-day morbidity and mortality, chest drain duration and length of stay) outcomes and was correlated with the number of resected lymph nodes and the rates of nodal upstaging. Continuous variables were presented as mean ± standard deviation and compared using the unpaired t-test; the X2 test was used for categorical variables. Univariable analysis was performed on selected variables. Significant variables (P < 0.30) were entered into a Cox multivariable logistic regression model, using the overall and specific occurrence of complications as dependent variables. The Spearman's rank correlation coefficient was applied as needed. RESULTS A total of 3181 cases (2077 men, 65.3%; mean age of 69 years) met the enrolment criteria. Final pathology was consistent with adenocarcinoma (n = 2262, 67.5%), squamous cell (n = 520, 15.5%), typical (n = 184, 5.5%) and atypical carcinoid (n = 48, 1.4%) and other (n = 335, 10%). The mean number of resected lymph nodes was 13.42 ± 8.24; nodal upstaging occurred in 308 of 3181 (9.68%) cases. Six hundred and fifty-five complications were recorded in 404 (12.7%) patients; in this series, no mortality was observed. Univariable and multivariable analyses did not show any association between the extension of LA and intraoperative or postoperative outcomes. The number of resected lymph nodes and nodal upstagings showed a minimal correlation with intraoperative outcomes and a moderate correlation with postoperative air leak (p = 0.35 and p = 0.48, respectively), arrhythmia (p = 0.29 and p = 0.35, respectively), chest drain duration (p = 0.35 and p = 0.51, respectively) and length of stay (p = 0.35). CONCLUSIONS Based on the VATS Group data, video-assisted thoracic surgery LA proved to be safe and displayed good outcomes even when performed with an extended approach.

Published
2018

30. Nodal management and upstaging of disease: Initial results from the Italian VATS Lobectomy Registry

Author

Bertani, Alessandro, Gonfiotti, Alessandro, Nosotti, Mario, Ferrari, Paolo Albino, De Monte, Lavinia, Russo, Emanuele, Di Paola, Gioacchino, Solli, Piero, Droghetti, Andrea, Bertolaccini, Luca, Crisci, Roberto, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, di Rienzo, Gaetano, Lopez, Camillo, Morelli, Angelo, Londero, Francesco, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Andretti, Claudio, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Benvenuti, Mauro Roberto, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, Guerrera, Francesco, Bertani, A, Gonfiotti, A, Nosotti, M, Ferrari, Pa, De Monte, L, Russo, E, Di Paola, G, Solli, P, Droghetti, A, Bertolaccini, L, Crisci, R, Italian VATS, Group, Negri, G, Bertani, Alessandro, Gonfiotti, Alessandro, Nosotti, Mario, Ferrari, Paolo Albino, De Monte, Lavinia, Russo, Emanuele, Di Paola, Gioacchino, Solli, Piero, Droghetti, Andrea, Bertolaccini, Luca, Crisci, Roberto, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, di Rienzo, Gaetano, Lopez, Camillo, Morelli, Angelo, Londero, Francesco, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Andretti, Claudio, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Benvenuti, Mauro Roberto, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, and Guerrera, Francesco

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Lymph node (LN), VATS lobectomy, Nodal upstaging, 030204 cardiovascular system & hematology, Resection, NO, 03 medical and health sciences, 0302 clinical medicine, medicine, Quantitative assessment, Lymph node, Surgical approach, Receiver operating characteristic, business.industry, lymph node (LN), nodal upstaging, Surgery, Dissection, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Original Article, Radiology, business
Abstract

Background: VATS lobectomy is an established option for the treatment of early-stage NSCLC. Complete lymph node dissection (CD), systematic sampling (SS) or resecting a specific number of lymph nodes (LNs) and stations are possible intra-operative LN management strategies. Methods: All VATS lobectomies from the “Italian VATS Group” prospective database were retrospectively reviewed. The type of surgical approach (CD or SS), number of LN resected (RN), the positive/resected LN ratio (LNR) and the number and types of positive LN stations were recorded. The rates of nodal upstaging were assessed based on different LN management strategies. Results: CD was the most frequent approach (72.3%). Nodal upstaging rates were 6.03% (N0-to-N1), 5.45% (N0-to-N2), and 0.58% (N1-to-N2). There was no difference in N1 or N2 upstaging rates between CD and SS. The number of resected nodes was correlated with both N1 (OR =1.02; CI, 1.01–1.04; P=0.03) and N2 (OR =1.02; CI, 1.01–1.05; P=0.001) upstaging. Resecting 12 nodes had the best ability to predict upstaging (6 N1 LN or 7 N2 LN). The finding of two positive LN stations best predicted N2 upstaging [area under the curve (AUC) of receiver operating characteristic (ROC) =0.98]. Conclusions: Nodal upstaging (and, indirectly, the effectiveness of intra-operative nodal management) cannot be predicted based on the surgical technique (CD or SS). A quantitative assessment of intra-operative LN management may be a more appropriate and measurable approach to justify the extension of LN resection during VATS lobectomy.

Published
2017

32. Chest wall reconstruction using a new titanium mesh: a multicenters experience

Author

Tamburini, Nicola, primary, Grossi, William, additional, Sanna, Stefano, additional, Campisi, Alessio, additional, Londero, Francesco, additional, Maniscalco, Pio, additional, Dolci, Giampiero, additional, Quarantotto, Francesco, additional, Daddi, Niccolò, additional, Morelli, Angelo, additional, Cavallesco, Giorgio, additional, and Dell’Amore, Andrea, additional

Published
2019
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35. Erratum: Nodal management and upstaging of disease: Initial results from the Italian VATS Lobectomy Registry [J Thorac Dis, 9, (2017), (2061-2070)] DOI: 10.21037/jtd.2017.06.12

Author

Bertani, Alessandro, Gonfiotti, Alessandro, Nosotti, Mario, Ferrari, Paolo Albino, De Monte, Lavinia, Russo, Emanuele, Di Paola, Gioacchino, Solli, Piero, Droghetti, Andrea, Bertolaccini, Luca, Crisci, Roberto, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, di Rienzo, Gaetano, Lopez, Camillo, Morelli, Angelo, Londero, Francesco, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Andretti, Claudio, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Benvenuti, Mauro Roberto, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, and Guerrera, Francesco

Subjects
Pulmonary and Respiratory Medicine, NO
Published
2017

41. Hemiarch Versus Arch Replacement in Acute Type A Aortic Dissection: Is the Occam's Razor Principle Applicable?

Author

Vendramin, Igor, Piani, Daniela, Lechiancole, Andrea, Sponga, Sandro, Di Nora, Concetta, Londero, Francesco, Muser, Daniele, Onorati, Francesco, Bortolotti, Uberto, and Livi, Ugolino

Subjects
AORTIC dissection, THORACIC aorta, HOSPITAL mortality, REOPERATION, AORTA
Abstract

Background and aim of the study: In patients with acute Type A aortic dissection (A-AAD) whether repair should be limited to ascending aorta/hemiarch replacement or extended to include the aortic arch is still debated. We have analyzed our experience to compare outcomes of patients with A-AAD treated with these 2 different surgical strategies. Methods: From 2006 to 2020, a total of 213 patients have undergone repair of A-AAD at our Center; in 163 of them ascending aorta/hemiarch replacement (Group 1) and in 75 ascending aorta and arch replacement (Group 2) were performed. The primary endpoint was early survival and secondary endpoints late survival, freedom from late complications and reoperations. Patients were compared according to era of operation: 2006 to 2013 (Era 1) and 2014 to 2020 (Era 2). Results: Overall hospital mortality was 12% and 5% in Group 1 and 2; mortality remained stable in Era 1 and 2 for Group 1 (15%), while it decreased from 8% to 1% in Group 2 patients (p = 0.24). Actuarial survival at 5 and 10 years is 72 ± 4% and 49 ± 5% in Group 1 and 77 ± 6% and 66 ± 9% in Group 2 (p = 0.073). Actuarial freedom from reoperation in the entire series is 94 ± 2% and 92 ± 3% at 5 and 10 years. Freedom from reoperation at 5 and 10 years is 92 ± 2% and 89 ± 3% in Group 1 and 98 ± 1% at all intervals in Group 2 (p = 0.068). Conclusions: An aggressive approach to A-AAD provides superior long-term results without increasing mortality. Furthermore, arch replacement during A-AAD repair represents a more stable solution with lower incidence of late aortic-related complications. Immediate aortic arch replacement should be considered in the treatment of A-AAD especially in experienced centers. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Lymphadenectomy during pulmonary metastasectomy: Impact on survival and recurrence

Author

Londero, Francesco, Morelli, Angelo, Parise, Orlando, Grossi, William, Crestale, Sara, Tetta, Cecilia, Johnson, Daniel M., Livi, Ugolino, Maessen, Jos G., Gelsomino, Sandro, Londero, Francesco, Morelli, Angelo, Parise, Orlando, Grossi, William, Crestale, Sara, Tetta, Cecilia, Johnson, Daniel M., Livi, Ugolino, Maessen, Jos G., and Gelsomino, Sandro

Abstract

Background and Objectives: Lymphadenectomy during pulmonary metastasectomy (PM) is widely carried out. We assessed the potential benefit on patient survival and tumor recurrence of this practice. Methods: One hundred eighty‐one patients undergoing a first PM were studied. Eighty‐six patients (47.5%) underwent lymphadenectomy (L+ group) whereas 95 (52.5%) did not undergo nodal harvesting (L−group). Main outcomes were overall survival (OS) and disease‐free survival (DFS). Median follow‐up was 25 months (interquartile range [IQR], 13‐49). Results: At follow‐up 84 patients (46.4%) died, whereas 97 (53.6%) were still alive with recurrence in 78 patients (43%). There was no difference in 5‐year survival (L+ 30.0% vs L− 43.2%; P = .87) or in the 5‐year cumulative incidence of recurrence (L + 63.2% vs L−80%; P = .07) between the two groups. Multivariable analysis indicated that disease‐free interval (DFI) less than 29 months (P < .001) and lung comorbidities (P = .003) were significant predictors of death. Metastases from non‐small–cell lung cancer increased the risk of lung comorbidities by a factor of 19.8, whereas the risk of DFI less than 29 months was increased nearly 11‐fold. Competing risk regression identified multiple metastases (P = .004), head/neck primary tumor (P = .009), and age less than 67 years (P = .024) as independent risk factors for recurrence. Conclusion: Associated lymphadenectomy showed not to give any additional advantage in terms of survival and recurrence after PM.

43. Lymphadenectomy during pulmonary metastasectomy: Impact on survival and recurrence

Author

Londero, Francesco, Morelli, Angelo, Parise, Orlando, Grossi, William, Crestale, Sara, Tetta, Cecilia, Johnson, Daniel M., Livi, Ugolino, Maessen, Jos G., Gelsomino, Sandro, Londero, Francesco, Morelli, Angelo, Parise, Orlando, Grossi, William, Crestale, Sara, Tetta, Cecilia, Johnson, Daniel M., Livi, Ugolino, Maessen, Jos G., and Gelsomino, Sandro

Abstract

Background and Objectives: Lymphadenectomy during pulmonary metastasectomy (PM) is widely carried out. We assessed the potential benefit on patient survival and tumor recurrence of this practice. Methods: One hundred eighty‐one patients undergoing a first PM were studied. Eighty‐six patients (47.5%) underwent lymphadenectomy (L+ group) whereas 95 (52.5%) did not undergo nodal harvesting (L−group). Main outcomes were overall survival (OS) and disease‐free survival (DFS). Median follow‐up was 25 months (interquartile range [IQR], 13‐49). Results: At follow‐up 84 patients (46.4%) died, whereas 97 (53.6%) were still alive with recurrence in 78 patients (43%). There was no difference in 5‐year survival (L+ 30.0% vs L− 43.2%; P = .87) or in the 5‐year cumulative incidence of recurrence (L + 63.2% vs L−80%; P = .07) between the two groups. Multivariable analysis indicated that disease‐free interval (DFI) less than 29 months (P < .001) and lung comorbidities (P = .003) were significant predictors of death. Metastases from non‐small–cell lung cancer increased the risk of lung comorbidities by a factor of 19.8, whereas the risk of DFI less than 29 months was increased nearly 11‐fold. Competing risk regression identified multiple metastases (P = .004), head/neck primary tumor (P = .009), and age less than 67 years (P = .024) as independent risk factors for recurrence. Conclusion: Associated lymphadenectomy showed not to give any additional advantage in terms of survival and recurrence after PM.

44. A risk stratification scheme for synchronous oligometastatic non-small cell lung cancer developed by a multicentre analysis

Author

Marco Lucchi, Lorena Costardi, Angelo Morelli, Domenico Viggiano, Angela De Palma, Filippo Tommaso Gallina, Michele Rusca, Giovanni Muriana, Silvia Ceccarelli, Andrea De Vico, Lorenzo Spaggiari, Giuseppe Marulli, Roberto Crisci, Angelo Carretta, Lorenzo Rosso, Enrico Ruffini, Paolo Mendogni, Francesco Puma, Luigi Ventura, Francesco Londero, Luca Bertolaccini, Edoardo Bottoni, Federico Rea, Marco Alloisio, Giuseppe Cardillo, Marco Schiavon, Maria Teresa Congedo, Nicola Tamburini, Pio Maniscalco, Giampiero Negri, Francesco Facciolo, Sara Ricciardi, Stefano Margaritora, Stefano Bongiolatti, Ilaria Ceccarelli, Luca Voltolini, Spaggiari, Lorenzo, Bertolaccini, Luca, Facciolo, Francesco, Tommaso Gallina, Filippo, Rea, Federico, Schiavon, Marco, Margaritora, Stefano, Congedo, Mariateresa, Lucchi, Marco, Ceccarelli, Ilaria, Alloisio, Marco, Bottoni, Edoardo, Negri, Giampiero, Carretta, Angelo, Cardillo, Giuseppe, Ricciardi, Sara, Ruffini, Enrico, Costardi, Lorena, Muriana, Giovanni, Viggiano, Domenico, Rusca, Michele, Ventura, Luigi, Marulli, Giuseppe, De Palma, Angela, Rosso, Lorenzo, Mendogni, Paolo, Crisci, Roberto, De Vico, Andrea, Maniscalco, Pio, Tamburini, Nicola, Puma, Francesco, Ceccarelli, Silvia, Voltolini Stefano Bongiolatti, Luca, Morelli, Angelo, and Londero, Francesco

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Risk classification, Kaplan-Meier Estimate, Biostatistics, Risk Assessment, Metastasis, Oligometastatic, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Settore MED/21 - CHIRURGIA TORACICA, Internal medicine, medicine, Adjuvant therapy, Humans, Radical surgery, Non-Small-Cell Lung, Lung cancer, Aged, Retrospective Studies, Thoracic surgery, Prognosis, Treatment Outcome, Proportional hazards model, business.industry, Medical record, Carcinoma, Retrospective cohort study, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, business, Risk assessment
Abstract

Backgrounds Oligometastatic Non-Small Cell Lung Cancer (NSCLC) patients represent a category without a standard therapeutic approach. However, in selected oligometastatic NSCLC, radical surgery seems to offer a good prognosis. This retrospective study aimed to analyse the long-term outcomes of synchronous oligometastatic patients treated with curative intent and identify the factors associated with better results and the proposal of a risk stratification system for classifying the synchronous oligometastatic NSCLC. Methods The medical records of patients from 18 centres with pathologically diagnosed synchronous oligometastatic NSCLC were retrospectively reviewed. The inclusion criteria were synchronous oligometastatic NSCLC, radical surgical treatment of the primary tumour with or without neoadjuvant/adjuvant therapy and radical treatment of all metastatic sites. The Kaplan – Meier method estimated survivals. A stratified backward stepwise Cox regression model was assessed for multivariable survival analyses. Results 281 patients were included. The most common site of metastasis was the brain, in 50.89 % patients. Median overall survival was 40 months (95 % CI: 29–53). Age ≤65 years (HR = 1.02, 95 % CI: 1.00–1.05; p = 0.019), single metastasis (HR = 0.71, 95 % CI: 0.45–1.13; p = 0.15) and presence of contralateral lung metastases (HR = 0.30, 95 % CI: 0.15 – 0.62; p = 0.001) were associated with a good prognosis. The presence of pathological N2 metastases negatively affected survival (HR = 2.00, 95 % CI: 1.21–3.32; p = 0.0065). These prognostic factors were used to build a simple risk classification scheme. Conclusions Treatment of selected synchronous oligometastatic NSCLC with curative purpose could be conducted safely and at acceptable 5-year survival levels, especially in younger patients with pN0 disease.

Published
2021

45. Conversion due to vascular injury during video-assisted thoracic surgery lobectomy: A multicentre retrospective analysis from the Italian video-assisted thoracic surgery group registry

Author

Luca Bertolaccini, Fabio Davoli, Alessandro Pardolesi, Jury Brandolini, Desideria Argnani, Alessandro Bertani, Andrea Droghetti, Alessandro Gonfiotti, Duilio Divisi, Roberto Crisci, Piergiorgio Solli, Mario Nosotti, Carlo Curcio, Dario Amore, Giuseppe Marulli, Samuele Nicotra, Andrea De Negri, Paola Maineri, Gaetano di Rienzo, Camillo Lopez, Angelo Morelli, Francesco Londero, Lorenzo Spaggiari, Roberto Gasparri, Guido Baietto, Caterina Casadio, Maurizio Infante, Cristiano Benato, Marco Alloisio, Edoardo Bottoni, Giuseppe Cardillo, Francesco Carleo, Franco Stella, Giampiero Dolci, Francesco Puma, Damiano Vinci, Giorgio Cavallesco, Pio Maniscalco, Luca Ampollini, Paolo Carbognani, Alberto Terzi, Andrea Viti, Giampiero Negri, Alessandro Bandiera, Reinhold Perkmann, Francesco Zaraca, Claudio Andretti, Camilla Poggi, Felice Mucilli, Pierpaolo Camplese, Luca Luzzi, Marco Ghisalberti, Andrea Imperatori, Nicola Rotolo, Luigi Bortolotti, Giovanna Rizzardi, Massimo Torre, Alessandro Rinaldo, Armando Sabbatini, Majed Refai, Mauro Roberto Benvenuti, Diego Benetti, Alessandro Stefani, Pamela Natali, Paolo Lausi, Francesco Guerrera, Bertolaccini, Luca, Davoli, Fabio, Pardolesi, Alessandro, Brandolini, Jury, Argnani, Desideria, Bertani, Alessandro, Droghetti, Andrea, Gonfiotti, Alessandro, Divisi, Duilio, Crisci, Roberto, Solli, Piergiorgio, Nosotti, Mario, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, di Rienzo, Gaetano, Lopez, Camillo, Morelli, Angelo, Londero, Francesco, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Andretti, Claudio, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Benvenuti, Mauro Roberto, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, Guerrera, Francesco, Bertolaccini L., Davoli F., Pardolesi A., Brandolini J., Argnani D., Bertani A., Droghetti A., Gonfiotti A., Divisi D., Crisci R., Solli P., Nosotti M., Curcio C., Amore D., Marulli G., Nicotra S., De Negri A., Maineri P., di Rienzo G., Lopez C., Morelli A., Londero F., Spaggiari L., Gasparri R., Baietto G., Casadio C., Infante M., Benato C., Alloisio M., Bottoni E., Cardillo G., Carleo F., Stella F., Dolci G., Puma F., Vinci D., Cavallesco G., Maniscalco P., Ampollini L., Carbognani P., Terzi A., Viti A., Negri G., Bandiera A., Perkmann R., Zaraca F., Andretti C., Poggi C., Mucilli F., Camplese P., Luzzi L., Ghisalberti M., Imperatori A., Rotolo N., Bortolotti L., Rizzardi G., Torre M., Rinaldo A., Sabbatini A., Refai M., Benvenuti M.R., Benetti D., Stefani A., Natali P., Lausi P., and Guerrera F.

Subjects
Registrie, Male, Complications, Lung Neoplasms, medicine.medical_treatment, Iatrogenic Disease, 030204 cardiovascular system & hematology, 0302 clinical medicine, Retrospective Studie, Risk Factors, Thoracotomy, Registries, Pneumonectomy, Video-assisted thoracic surgery lobectomy, Univariate analysis, Thoracic Surgery, Video-Assisted, Thoracic Surgery, General Medicine, Treatment Outcome, Oncology, Italy, Cardiothoracic surgery, Female, Lung cancer, Human, medicine.medical_specialty, Complications, Conversion, Lung cancer, Lymph nodes dissection, Vascular injury, Video-assisted thoracic surgery lobectomy, VATS lobectomy, Video-Assisted, Vascular injury, NO, 03 medical and health sciences, medicine, Conversion, Lymph nodes dissection, Aged, Humans, Retrospective Studies, Vascular System Injuries, business.industry, Risk Factor, nutritional and metabolic diseases, Retrospective cohort study, medicine.disease, Surgery, Lung Neoplasm, 030228 respiratory system, business, Complication
Abstract

Objectives Vascular injuries are among the most severe causes of unplanned conversion during VATS lobectomies. The study aimed to analyse the incidence of vascular injuries and their risk factors during VATS lobectomy. Methods The Italian VATS lobectomy Registry was used to collect data from 66 Thoracic Surgery Units. From 2013 to October 2016 (out of more than 3,700 patients enrolled) only information from Units with an enrollment >100 VATS lobectomies were retrospectively analysed. Logistic regression analysis was performed on selected variables of the univariate analysis. Results Ten institutions contributed a total of 1,679 patients. Vascular injuries leading to conversion occurred in 44 (2.6%) patients. Years of experiences were inversely related to the risk of vascular injuries. Univariate analysis showed age, gender, surgical activity, Charlson Index Score and number of resected lymph nodes like significantly associated variables. Multivariate analysis revealed that number of resected lymph nodes, VATS experience ratio (number of VATS lobectomies/total lobectomies performed in the same year at same centre), and surgical activity of the centre were significantly associated with the risk of conversion. Unplanned thoracotomy was correlated with postoperative morbidity. Conclusion Vascular injuries in VATS lobectomies represented a rare complication which could directly affect the postoperative outcomes. The predictive factors for conversion were multifactorial and depended on characteristics of centres and surgeons’ seniority. Minimally invasive VATS lobectomy approaches did not influence the risk of vascular damages.

Published
2019

46. Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study.

Author

Guerrera F, Falcoz PE, Moser B, van Raemdonck D, Bille' A, Toker A, Spaggiari L, Ampollini L, Filippini C, Thomas PA, Verdonck B, Mendogni P, Aigner C, Voltolini L, Novoa N, Patella M, Mantovani S, Bravio IG, Zisis C, Guirao A, Londero F, Congregado M, Rocco G, Du Pont B, Martucci N, Esch M, Brunelli A, Detterbeck FC, Venuta F, Weder W, Ruffini E, Klepetko W, Olland A, Du Pont B, Nonaka D, Ozkan B, Lo Iacono G, Braggio C, Filosso PL, Brioude G, van Schil P, Nosotti M, Valdivia D, Bongiolatti S, Inci I, Dimitra R, Sànchez D, Grossi W, Moreno-Merino S, and Teschner M

Subjects
Humans, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Retrospective Studies, Thymectomy adverse effects, Thymus Gland pathology, Thymus Gland surgery, Myasthenia Gravis epidemiology, Myasthenia Gravis pathology, Myasthenia Gravis surgery, Surgeons, Thymoma pathology, Thymoma surgery, Thymus Neoplasms pathology, Thymus Neoplasms surgery
Abstract

Objectives: Resection of thymic tumours including the removal of both the tumour and the thymus gland (thymothymectomy; TT) is the procedure of choice and is recommended in most relevant articles in the literature. Nevertheless, in recent years, some authors have suggested that resection of the tumour (simple thymomectomy; ST) may suffice from an oncological standpoint in patients with early-stage thymoma who do not have myasthenia gravis (MG) (non-MG). The goal of our study was to compare the short- and long-term outcomes of ST versus TT in non-MG early-stage thymomas using the European Society of Thoracic Surgeons thymic database., Methods: A total of 498 non-MG patients with pathological stage I thymoma were included in the study. TT was performed in 466 (93.6%) of 498 patients who had surgery with curative intent; ST was done in 32 (6.4%). The completeness of resection, the rate of complications, the 30-day mortality, the overall recurrence and the freedom from recurrence were compared. We performed crude and propensity score-adjusted comparisons by surgical approach (ST vs TT)., Results: TT showed the same rate of postoperative complications, 30-day mortality and postoperative length of stay as ST. The 5-year overall survival rate was 89% in the TT group and 55% in the ST group. The 5-year freedom from recurrence was 96% in the TT group and 79% in the ST group., Conclusion: Patients with early-stage thymoma without MG who have a TT show significantly better freedom from recurrence than those who have an ST, without an increase in postoperative morbidity rate., (© The Author(s) 2021. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)

Published
2021
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47. Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern.

Author

Bresadola V, Adani GL, Londero F, Leo CA, Cherchi V, Lorenzin D, Rossetto A, Vit G, Baccarani U, Terrosu G, and Anna DD

Abstract

Aim: To investigate differences in the physiopathological findings (manometry and pH monitoring) and symptoms between cases of non-erosive reflux disease (NERD) and erosive reflux disease (ERD) found positive at 24 h pH monitoring., Methods: For a total of 670 patients who underwent 24 h pH monitoring, esophageal manometry and upper endoscopy were retrospectively evaluated, assessing the reflux symptoms, manometric characteristics of the lower esophageal sphincter (LES) and esophageal body and the presence or absence of esophagitis and hiatal hernia. Typical and atypical symptoms were also evaluated. For inclusion in the study, patients had to have NERD or ERD and be found positive on pH monitoring (NERD+). Patients with Gastroesophageal reflux disease (GERD) complicated by stenosis, ulcers or Barrett's esophagus were ruled out., Results: 214 patients were involved in the study, i.e. 107 cases of NERD+ and 107 of ERD. There were no significant gender- or age-related differences between the two groups. The ERD group had more cases of hiatal hernia (P = 0.02) and more acid reflux, both in terms of number of reflux episodes (P = 0.01) and as a percentage of the total time with a pH < 4 (P = 0.00), when upright (P = 0.007) and supine (P = 0.00). The NERD+ cases had more reflux episodes while upright (P = 0.02) and the ERD cases while supine (P = 0.01). The LES pressure was higher in cases of NERD+ (P = 0.03) while the amplitude and duration of their esophageal peristaltic waves tended to be better than in the ERD group (P >0.05). The NERD+ patients presented more often with atypical symptoms (P = 0.01)., Conclusion: The NERD+ patients' fewer reflux episodes and the fact that they occurred mainly while in the upright position (unlike the cases of ERD) may be two factors that do not favor the onset of esophagitis. The frequently atypical symptoms seen in patients with NERD+ need to be accurately evaluated for therapeutic purposes because patients with GERD and atypical symptoms generally respond only partially to medical and surgical treatments.

Published
2011
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