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1. Knowledge, awareness, and risk practices related to bacterial contamination of antiseptics, disinfectants, and hand hygiene products among healthcare workers in sub-saharan Africa: a cross-sectional survey in three tertiary care hospitals (Benin, Burkina Faso, and DR Congo)

Author

Lompo, Palpouguini, Heroes, Anne-Sophie, Ouédraogo, Kadija, Okitale, Patient, Wakpo, Abel, Kalema, Jocelyne, Lunguya, Octavie, Tinto, Halidou, Affolabi, Dissou, Sangaré, Lassana, and Jacobs, Jan

Published
2024
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3. A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa

Author

Van Puyvelde, Sandra, de Block, Tessa, Sridhar, Sushmita, Bawn, Matt, Kingsley, Robert A., Ingelbeen, Brecht, Beale, Mathew A., Barbé, Barbara, Jeon, Hyon Jin, Mbuyi-Kalonji, Lisette, Phoba, Marie-France, Falay, Dadi, Martiny, Delphine, Vandenberg, Olivier, Affolabi, Dissou, Rutanga, Jean Pierre, Ceyssens, Pieter-Jan, Mattheus, Wesley, Cuypers, Wim L., van der Sande, Marianne A. B., Park, Se Eun, Kariuki, Simon, Otieno, Kephas, Lusingu, John P. A., Mbwana, Joyce R., Adjei, Samuel, Sarfo, Anima, Agyei, Seth O., Asante, Kwaku P., Otieno, Walter, Otieno, Lucas, Tahita, Marc C., Lompo, Palpouguini, Hoffman, Irving F., Mvalo, Tisungane, Msefula, Chisomo, Hassan-Hanga, Fatimah, Obaro, Stephen, Mackenzie, Grant, Deborggraeve, Stijn, Feasey, Nicholas, Marks, Florian, MacLennan, Calman A., Thomson, Nicholas R., Jacobs, Jan, Dougan, Gordon, Kariuki, Samuel, and Lunguya, Octavie

Published
2023
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4. Epidemiological cut-off value and antibiotic susceptibility test methods for azithromycin in a collection of multi-country invasive non-typhoidal Salmonella

Author

Tack, Bieke, Phoba, Marie-France, Thong, Phe, Lompo, Palpouguini, Hupko, Charlien, Desmet, Stefanie, Martiny, Delphine, Mattheus, Wesley, Pardos de la Gandara, Maria, Mbuyi-Kalonji, Lisette, Kuijpers, Laura, Prevost, Benoit, Barbé, Barbara, Vandenberg, Olivier, Lunguya, Octavie, Ruiz, Joaquim, Jacobs, Jan, and Hardy, Liselotte

Published
2022
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5. Impact and operational feasibility of adding malaria infection screening using an ultrasensitive RDT for placental and fetal outcomes in an area of high IPTP-SP coverage in Burkina Faso: the ASSER MALARIA pilot study protocol

Author

Tahita, Marc Christian, Sondo, Paul, Kabore, Berenger, Ilboudo, Hamidou, Rouamba, Toussaint, Sanou, Hyacinthe, Ouédraogo, Kadija, Compaoré, Adélaïde, Lompo, Palpouguini, Ouedraogo, Florence, Sawadogo, Seydou, Derra, Karim, Sawadogo, Yabré Edmond, Somé, Athanase M., Nana, Macaire, Sorgho, Hermann, Traore-Coulibaly, Maminata, Bassat, Quique, and Tinto, Halidou

Published
2022
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8. Immunological and Haematological Relevance of Helminths and Mycobacterium tuberculosis Complex Coinfection among Newly Diagnosed Pulmonary Tuberculosis Patients from Bobo-Dioulasso, Burkina Faso.

Author

Djibougou, Diakourga Arthur, Mensah, Gloria Ivy, Kaboré, Achille, Toé, Inoussa, Sawadogo, Leon Tinnoga, Lompo, Palpouguini Felix, Kone, Amariane M. M., Hien, Hervé, Meda, Clement Ziemlé, Combary, Adjima, Bonfoh, Bassirou, Addo, Kennedy Kwasi, Belem, Adrien Marie-Gaston, Dabiré, Roch Konbobr, Hoffmann, Jonathan, Perreau, Matthieu, and Diagbouga, Potiandi Serge

Subjects
MYCOBACTERIUM tuberculosis, HELMINTHIASIS, TUBERCULOSIS patients, TUBERCULOSIS, CD4 lymphocyte count
Abstract

The effect of helminthiasis on host immunity is a neglected area of research, particularly in tuberculosis (TB) infection. This study aimed to evaluate the effect of helminthiasis on immunological and haematological parameters in newly diagnosed TB patients in Bobo-Dioulasso. After all biological analyses, we formed three subpopulations: group 1 (n = 82), as control, were participants without helminthic or Mycobacterium tuberculosis complex infection (Mtb−/Helm−), group 2 (n = 73) were TB patients without helminthic infection (Mtb+/Helm−), and group 3 (n = 22) were TB patients with helminthic infection (Mtb+/Helm+). The proportion of helminth coinfection was 23.16% (22/95) in TB patients, and Schistosoma mansoni infection was found in 77.3% (17/22) cases of helminthiasis observed in this study. A low CD4 T cell count and a low CD4:CD8 ratio were significantly associated with concomitant infection with helminths and the Mtb complex (Mtb+/Helm+) compared to the other groups (p < 0.05). However, there was no statistically significant difference in the CD8 median among the three participating groups (p > 0.05). Lymphopenia, monocytosis, thrombocytosis, and hypochromic microcytic anaemia were the haematological defects observed in the Mtb+/Helm+ and Mtb+/Helm− patients. Exploring these types of immune–haematological biomarkers would be a valuable aid in diagnosing and a better follow-up and monitoring of the tuberculosis–helminthiasis coinfection. [ABSTRACT FROM AUTHOR]

Published
2024
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9. PA-730 Impact of additional screening using highly-sensitive rapid diagnostic tests and treatment combined with monthly Sulfadoxine-Pyrimethamine on LBW and peripheral malaria infection: asser malaria study

Author

Tahita, Marc Christian, primary, Sondo, Paul, additional, Kabore, Berenger, additional, Ilboudo, Hamidou, additional, Rouamba, Toussaint, additional, Sanou, Hyacinthe, additional, Ouedraogo, Kadija, additional, Lompo, Palpouguini, additional, Ouedraogo, Florence, additional, Sawadogo, Seydou, additional, Derra, Karim, additional, Some, Athanase M, additional, Sorgho, Hermann, additional, Bassat, Quique, additional, and Tinto, Halidou, additional

Published
2023
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10. Clinical bacteriology in low-resource settings: today's solutions

Author

LUNGUYA, Octavie, PHOBA, Marie-France, LOMPO, Palpouguini, PHE, Thong, KARIUKI, Samuel, NEWTON, Paul N, DANCE, David A B, MUVUNYI, Claude, EL SAFI, Sayda, BARBE, Barbara, FALAY, Dadi, AFFOLABI, Dissou, PAGE, Maurice, LANGENDORF, Céline, GILLE, Yves, LEENSTRA, Tjalling, STELLING, John, NAAS, Thierry, KESTEMAN, Thomas, SEIFU, Daniel, DELAROCQUE-ASTAGNEAU, Elisabeth, SCHULTSZ, Constance, SCHUTT-GEROWITT, Heidi, LETCHFORD, Joanne, WERTHEIM, Heiman, KAHLMETER, Gunnar, AIDARA KANE, Awa, Ombelet, Sien, Ronat, Jean-Baptiste, Walsh, Timothy, Yansouni, Cedric P, Cox, Janneke, Vlieghe, Erika, Martiny, Delphine, Semret, Makeda, Vandenberg, Olivier, and Jacobs, Jan

Published
2018
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13. A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa

Author

Infection & Immunity, Epi Infectieziekten Team 1, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Van Puyvelde, Sandra, de Block, Tessa, Sridhar, Sushmita, Bawn, Matt, Kingsley, Robert A., Ingelbeen, Brecht, Beale, Mathew A., Barbé, Barbara, Jeon, Hyon Jin, Mbuyi-Kalonji, Lisette, Phoba, Marie France, Falay, Dadi, Martiny, Delphine, Vandenberg, Olivier, Affolabi, Dissou, Rutanga, Jean Pierre, Ceyssens, Pieter Jan, Mattheus, Wesley, Cuypers, Wim L., van der Sande, Marianne A.B., Park, Se Eun, Kariuki, Simon, Otieno, Kephas, Lusingu, John P.A., Mbwana, Joyce R., Adjei, Samuel, Sarfo, Anima, Agyei, Seth O., Asante, Kwaku P., Otieno, Walter, Otieno, Lucas, Tahita, Marc C., Lompo, Palpouguini, Hoffman, Irving F., Mvalo, Tisungane, Msefula, Chisomo, Hassan-Hanga, Fatimah, Obaro, Stephen, Mackenzie, Grant, Deborggraeve, Stijn, Feasey, Nicholas, Marks, Florian, MacLennan, Calman A., Thomson, Nicholas R., Jacobs, Jan, Dougan, Gordon, Kariuki, Samuel, Lunguya, Octavie, Infection & Immunity, Epi Infectieziekten Team 1, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Van Puyvelde, Sandra, de Block, Tessa, Sridhar, Sushmita, Bawn, Matt, Kingsley, Robert A., Ingelbeen, Brecht, Beale, Mathew A., Barbé, Barbara, Jeon, Hyon Jin, Mbuyi-Kalonji, Lisette, Phoba, Marie France, Falay, Dadi, Martiny, Delphine, Vandenberg, Olivier, Affolabi, Dissou, Rutanga, Jean Pierre, Ceyssens, Pieter Jan, Mattheus, Wesley, Cuypers, Wim L., van der Sande, Marianne A.B., Park, Se Eun, Kariuki, Simon, Otieno, Kephas, Lusingu, John P.A., Mbwana, Joyce R., Adjei, Samuel, Sarfo, Anima, Agyei, Seth O., Asante, Kwaku P., Otieno, Walter, Otieno, Lucas, Tahita, Marc C., Lompo, Palpouguini, Hoffman, Irving F., Mvalo, Tisungane, Msefula, Chisomo, Hassan-Hanga, Fatimah, Obaro, Stephen, Mackenzie, Grant, Deborggraeve, Stijn, Feasey, Nicholas, Marks, Florian, MacLennan, Calman A., Thomson, Nicholas R., Jacobs, Jan, Dougan, Gordon, Kariuki, Samuel, and Lunguya, Octavie

Published
2023

15. Bacterial Contamination of Antiseptics, Disinfectants, and Hand Hygiene Products Used in Healthcare Settings in Low- and Middle-Income Countries—A Systematic Review

Author

Lompo, Palpouguini, primary, Agbobli, Esenam, additional, Heroes, Anne-Sophie, additional, Van den Poel, Bea, additional, Kühne, Vera, additional, Kpossou, Cyprien M. Gutemberg, additional, Zida, Adama, additional, Tinto, Halidou, additional, Affolabi, Dissou, additional, and Jacobs, Jan, additional

Published
2023
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19. Growth of Gram-Negative Bacteria in Antiseptics, Disinfectants and Hand Hygiene Products in Two Tertiary Care Hospitals in West Africa—A Cross-Sectional Survey.

Author

Lompo, Palpouguini, Heroes, Anne-Sophie, Agbobli, Esenam, Kazienga, Adama, Peeters, Marjan, Tinto, Halidou, Lagrou, Katrien, Sangaré, Lassana, Affolabi, Dissou, and Jacobs, Jan

Subjects
HAND care & hygiene, GRAM-negative bacteria, HYGIENE products, DISINFECTION & disinfectants, ACINETOBACTER baumannii, CARBAPENEMS
Abstract

Antiseptics, disinfectants, and hand hygiene products can act as reservoirs of Gram-negative bacteria causing healthcare-associated infections. This problem is rarely documented in low- and middle-income countries, particularly in sub-Saharan Africa. In a cross-sectional survey, we assessed the bacterial contamination of antiseptics, disinfectants, and hand hygiene products in two university hospitals in Burkina Faso and Benin. During ward visits and staff interviews, in-use products were cultured for the presence of Gram-negative bacteria. The growth of Gram-negative bacteria was absent or rare in alcohol-based products, povidone iodine, and Dakin solution. Contamination was highest (73.9% (51/69)) for liquid soap products (versus antiseptic/disinfectants (4.5%, 7/157) (p < 0.0001)), mostly used in high-risk areas and associated with high total bacterial counts (>10,000 colony-forming units/mL). Contaminating flora (105 isolates) included Enterobacterales and the Vibrio non-cholerae/Aeromonas group (17.1%) and non-fermentative Gram-negative rods (82.8%). Multidrug resistance was present among 9/16 Enterobacterales (Klebsiella and Enterobacter spp.) and 3/12 Acinetobacter spp., including carbapenem resistance (Acinetobacter baumannii: NDM, Pseudomonas stutzeri: VIM). The risk factors for contamination included the type of product (cleaning grade and in-house prepared liquid soap), use of recycled disposable containers and soft drink bottles, absence of labeling, topping-up of containers, dilution with tap water (pharmacy and ward), and poor-quality management (procurement, stock management, expiry dates, and period after opening). [ABSTRACT FROM AUTHOR]

Published
2023
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20. Use of WATCH antibiotics prior to presentation to the hospital in rural Burkina Faso

Author

Communicatie, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Valia, Daniel, Ingelbeen, Brecht, Kaboré, Bérenger, Karama, Ibrahima, Peeters, Marjan, Lompo, Palpouguini, Vlieghe, Erika, Post, Annelies, Cox, Janneke, de Mast, Quirijn, Robert, Annie, van der Sande, Marianne A.B., Villalobos, Hector Rodriguez, van der Ven, Andre, Tinto, Halidou, Jacobs, Jan, Communicatie, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Valia, Daniel, Ingelbeen, Brecht, Kaboré, Bérenger, Karama, Ibrahima, Peeters, Marjan, Lompo, Palpouguini, Vlieghe, Erika, Post, Annelies, Cox, Janneke, de Mast, Quirijn, Robert, Annie, van der Sande, Marianne A.B., Villalobos, Hector Rodriguez, van der Ven, Andre, Tinto, Halidou, and Jacobs, Jan

Published
2022

21. Use of WATCH antibiotics prior to presentation to the hospital in rural Burkina Faso

Author

UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - SSS/IREC/EPID - Pôle d'épidémiologie et biostatistique, Valia, Daniel, Ingelbeen, Brecht, Kaboré, Bérenger, Karama, Ibrahima, Peeters, Marjan, Lompo, Palpouguini, Vlieghe, Erika, Post, Annelies, Cox, Janneke, de Mast, Quirijn, Robert, Annie, van der Sande, Marianne A. B., Rodriguez-Villalobos, Hector, van der Ven, Andre, Tinto, Halidou, Jacobs, Jan, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - SSS/IREC/EPID - Pôle d'épidémiologie et biostatistique, Valia, Daniel, Ingelbeen, Brecht, Kaboré, Bérenger, Karama, Ibrahima, Peeters, Marjan, Lompo, Palpouguini, Vlieghe, Erika, Post, Annelies, Cox, Janneke, de Mast, Quirijn, Robert, Annie, van der Sande, Marianne A. B., Rodriguez-Villalobos, Hector, van der Ven, Andre, Tinto, Halidou, and Jacobs, Jan

Abstract

BACKGROUND: In low- and middle-income countries, the prevalence of antimicrobial resistance (AMR) is increasing. To control AMR, WHO recommends monitoring antibiotic use, in particular Watch antibiotics. These are critically important antibiotics, with restricted use because at risk of becoming ineffective due to increasing AMR. We investigated pre-hospital antibiotic use in rural Burkina Faso. METHODS: During 2016–2017, we collected data from patients aged > 3 months presenting with severe acute fever to the rural hospital of Nanoro Health District, Burkina Faso, including antibiotic use in the two weeks prior to consultation or hospitalization. We analysed reported antibiotic use by applying the WHO Access, Watch, Reserve classification. RESULTS: Of 920 febrile participants (63.0% ≤ 14 years), pre-hospital antibiotic use was reported by 363 (39.5%).Among these 363, microbiological diagnoses were available for 275 (75.8%) patients, of whom 162 (58.9%) were non-bacterial infections. Use of more than one antibiotic was reported by 58/363 (16.0%) participants. Of 491 selfreferred patients who did not previously visit a primary health care center, 131 (26.7%) reported antibiotic use. Of 424 antibiotics reported, 265 (62.5%) were Access and 159 (37.5%) Watch antibiotics. Watch antibiotic use was more frequent among patients > 14 year olds (51.1%) compared to those 0–14 year old (30.7%, p < 0.001) and among referrals from the primary health care centers (42.2%) compared to self-referred patients (28.1%, p = 0.004). Most frequently reported Watch antibiotics were ceftriaxone (114, 71.7%) and ciprofloxacin (32, 20.1%). CONCLUSION: The reported frequent use of Watch group antibiotics among febrile patients prior to presentation to the hospital in rural Burkina Faso highlights the need to develop targeted interventions to improve antibiotic use in community settings as part of strengthening antibiotic stewardship in low- and middle-income countries. This should include facil

Published
2022

22. Diagnosis of Bacterial Bloodstream Infections: A 16S Metagenomics Approach.

Author

Saskia Decuypere, Conor J Meehan, Sandra Van Puyvelde, Tessa De Block, Jessica Maltha, Lompo Palpouguini, Marc Tahita, Halidou Tinto, Jan Jacobs, and Stijn Deborggraeve

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

BACKGROUND:Bacterial bloodstream infection (bBSI) is one of the leading causes of death in critically ill patients and accurate diagnosis is therefore crucial. We here report a 16S metagenomics approach for diagnosing and understanding bBSI. METHODOLOGY/PRINCIPAL FINDINGS:The proof-of-concept was delivered in 75 children (median age 15 months) with severe febrile illness in Burkina Faso. Standard blood culture and malaria testing were conducted at the time of hospital admission. 16S metagenomics testing was done retrospectively and in duplicate on the blood of all patients. Total DNA was extracted from the blood and the V3-V4 regions of the bacterial 16S rRNA genes were amplified by PCR and deep sequenced on an Illumina MiSeq sequencer. Paired reads were curated, taxonomically labeled, and filtered. Blood culture diagnosed bBSI in 12 patients, but this number increased to 22 patients when combining blood culture and 16S metagenomics results. In addition to superior sensitivity compared to standard blood culture, 16S metagenomics revealed important novel insights into the nature of bBSI. Patients with acute malaria or recovering from malaria had a 7-fold higher risk of presenting polymicrobial bloodstream infections compared to patients with no recent malaria diagnosis (p-value = 0.046). Malaria is known to affect epithelial gut function and may thus facilitate bacterial translocation from the intestinal lumen to the blood. Importantly, patients with such polymicrobial blood infections showed a 9-fold higher risk factor for not surviving their febrile illness (p-value = 0.030). CONCLUSIONS/SIGNIFICANCE:Our data demonstrate that 16S metagenomics is a powerful approach for the diagnosis and understanding of bBSI. This proof-of-concept study also showed that appropriate control samples are crucial to detect background signals due to environmental contamination.

Published
2016
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23. Etiology of severe invasive infections in young infants in rural settings in sub-Saharan Africa

Author

Mduma, Estomih, primary, Halidou, Tinto, additional, Kaboré, Berenger, additional, Walongo, Thomas, additional, Lompo, Palpouguini, additional, Museveni, Justine, additional, Gidabayda, Joshua, additional, Gratz, Jean, additional, Guga, Godfrey, additional, Kimathi, Caroline, additional, Liu, Jie, additional, Mdoe, Paschal, additional, Moshiro, Robert, additional, Petzold, Max, additional, Singlovic, Jan, additional, Guillerm, Martine, additional, Gomes, Melba F., additional, Houpt, Eric R., additional, and Halleux, Christine M., additional

Published
2022
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24. Use of WATCH antibiotics prior to presentation to the hospital in rural Burkina Faso

Author

VALIA, Daniel, primary, Ingelbeen, Brecht, additional, Kaboré, Bérenger, additional, Karama, Ibrahima, additional, Peeters, Marjan, additional, Lompo, Palpouguini, additional, Vlieghe, Erika, additional, Post, Annelies, additional, Cox, Janneke, additional, de Mast, Quirijn, additional, Robert, Annie, additional, Sande, Marianne A.B. van der, additional, Villalobos, Hector Rodriguez, additional, Ven, Andre van der, additional, Tinto, Halidou, additional, and Jacobs, Jan, additional

Published
2021
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26. Antibiotic Susceptibility of Staphylococcus aureus and Streptococcus pneumoniae Isolates from the Nasopharynx of Febrile Children under 5 Years in Nanoro, Burkina Faso

Author

Bonko, Massa dit Achille, primary, Lompo, Palpouguini, additional, Tahita, Marc Christian, additional, Kiemde, Francois, additional, Karama, Ibrahima, additional, Somé, Athanase M., additional, Mens, Petra F., additional, Menting, Sandra, additional, Tinto, Halidou, additional, and D. F. H. Schallig, Henk, additional

Published
2021
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27. Infection Manager System (IMS) as a new hemocytometry-based bacteremia detection tool: A diagnostic accuracy study in a malaria-endemic area of Burkina Faso

Author

Post, Annelies, primary, Kaboré, Berenger, additional, Bognini, Joel, additional, Diallo, Salou, additional, Lompo, Palpouguini, additional, Kam, Basile, additional, Herssens, Natacha, additional, van Opzeeland, Fred, additional, van der Gaast-de Jongh, Christa E., additional, Langereis, Jeroen D., additional, de Jonge, Marien I., additional, Rahamat-Langendoen, Janette, additional, Bousema, Teun, additional, Wertheim, Heiman, additional, Sauerwein, Robert W., additional, Tinto, Halidou, additional, Jacobs, Jan, additional, de Mast, Quirijn, additional, and van der Ven, Andre J., additional

Published
2021
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28. Pathogens associated with acute diarrhea, and comorbidity with malaria among children under five years old in rural Burkina Faso

Author

Lompo, Palpouguini, primary, Tahita, Marc Christian, additional, Sorgho, Hermann, additional, Kaboré, William Christian, additional, Kazienga, Adama, additional, Nana, Ashmed Cheick Bachirou, additional, Natama, Hamtandi Magloire, additional, Ouindgueta Bonkoungou, Isidore Juste, additional, Barro, Nicolas, additional, and Tinto, Halidou, additional

Published
2021
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30. Antibiotic susceptibility profile of bacterial pathogens isolated from febrile children under 5 years of age in Nanoro, Burkina Faso

Author

BONKO, Massa dit Achille, primary, Tahita, Marc Christian, additional, Kiemde, Francois, additional, Lompo, Palpouguini, additional, Yougbaré, Sibidou, additional, Some, Athanase M., additional, Tinto, Halidou, additional, Mens, Petra F., additional, Menting, Sandra, additional, and Schallig, Henk D. F. H., additional

Published
2020
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31. Long-term immunogenicity and immune memory response to the hepatitis B antigen in the RTS,S/AS01E malaria vaccine in African children: a randomized trial

Author

Valéa, Innocent, primary, Adjei, Samuel, additional, Usuf, Effua, additional, Traore, Ousmane, additional, Ansong, Daniel, additional, Tinto, Halidou, additional, Owusu Boateng, Harry, additional, Some, Athanase Mwinessobaonfou, additional, Buabeng, Patrick, additional, Vekemans, Johan, additional, Kotey, Amos, additional, Vandoolaeghe, Pascale, additional, Cullinane, Mark, additional, Traskine, Magali, additional, Ouedraogo, Florence, additional, Sambian, David, additional, Lievens, Marc, additional, Tahita, Marc Christian, additional, Jongert, Erik, additional, Lompo, Palpouguini, additional, Idriss, Ali, additional, Borys, Dorota, additional, Ouedraogo, Sayouba, additional, Prempeh, Frank, additional, Schuerman, Lode, additional, Sorgho, Hermann, additional, and Agbenyega, Tsiri, additional

Published
2020
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32. Supporting evidence for a human reservoir of invasive non-Typhoidal Salmonella from household samples in Burkina Faso

Author

Post, Annelies S., primary, Diallo, Seydou Nakanabo, additional, Guiraud, Issa, additional, Lompo, Palpouguini, additional, Tahita, Marc Christian, additional, Maltha, Jessica, additional, Van Puyvelde, Sandra, additional, Mattheus, Wesley, additional, Ley, Benedikt, additional, Thriemer, Kamala, additional, Rouamba, Eli, additional, Derra, Karim, additional, Deborggraeve, Stijn, additional, Tinto, Halidou, additional, and Jacobs, Jan, additional

Published
2019
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34. Supporting evidence for a human reservoir of invasive non-Typhoidal Salmonella from household samples in Burkina Faso

Author

Post, A.S., Diallo, Seydou Nakanabo, Guiraud, Issa, Lompo, Palpouguini, Tahita, Marc Christian, Maltha, Jessica, Tinto, Halidou, Jacobs, Jan, Post, A.S., Diallo, Seydou Nakanabo, Guiraud, Issa, Lompo, Palpouguini, Tahita, Marc Christian, Maltha, Jessica, Tinto, Halidou, and Jacobs, Jan

Abstract

Contains fulltext : 210099.pdf (publisher's version ) (Open Access)

Published
2019

35. Long-term immunogenicity and immune memory response to the hepatitis B antigen in the RTS,S/AS01E malaria vaccine in African children: a randomized trial.

Author

Valéa, Innocent, Adjei, Samuel, Usuf, Effua, Traore, Ousmane, Ansong, Daniel, Tinto, Halidou, Owusu Boateng, Harry, Some, Athanase Mwinessobaonfou, Buabeng, Patrick, Vekemans, Johan, Kotey, Amos, Vandoolaeghe, Pascale, Cullinane, Mark, Traskine, Magali, Ouedraogo, Florence, Sambian, David, Lievens, Marc, Tahita, Marc Christian, Jongert, Erik, and Lompo, Palpouguini

Published
2020
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36. Clinical bacteriology in low-resource settings: today's solutions

Author

Ombelet, Sien, primary, Ronat, Jean-Baptiste, additional, Walsh, Timothy, additional, Yansouni, Cedric P, additional, Cox, Janneke, additional, Vlieghe, Erika, additional, Martiny, Delphine, additional, Semret, Makeda, additional, Vandenberg, Olivier, additional, Jacobs, Jan, additional, LUNGUYA, Octavie, additional, PHOBA, Marie-France, additional, LOMPO, Palpouguini, additional, PHE, Thong, additional, KARIUKI, Samuel, additional, NEWTON, Paul N, additional, DANCE, David A B, additional, MUVUNYI, Claude, additional, EL SAFI, Sayda, additional, BARBE, Barbara, additional, FALAY, Dadi, additional, AFFOLABI, Dissou, additional, PAGE, Maurice, additional, LANGENDORF, Céline, additional, GILLE, Yves, additional, LEENSTRA, Tjalling, additional, STELLING, John, additional, NAAS, Thierry, additional, KESTEMAN, Thomas, additional, SEIFU, Daniel, additional, DELAROCQUE-ASTAGNEAU, Elisabeth, additional, SCHULTSZ, Constance, additional, SCHUTT-GEROWITT, Heidi, additional, LETCHFORD, Joanne, additional, WERTHEIM, Heiman, additional, KAHLMETER, Gunnar, additional, and AIDARA KANE, Awa, additional

Published
2018
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37. Immune response to the hepatitis B antigen in the RTS,S/AS01 malaria vaccine, and co-administration with pneumococcal conjugate and rotavirus vaccines in African children: A randomized controlled trial

Author

Valéa, Innocent, primary, Adjei, Samuel, additional, Usuf, Effua, additional, Traore, Ousmane, additional, Ansong, Daniel, additional, Tinto, Halidou, additional, Owusu Boateng, Harry, additional, Leach, Amanda, additional, Mwinessobaonfou Some, Athanase, additional, Buabeng, Patrick, additional, Vekemans, Johan, additional, Nana, Louis Arnaud, additional, Kotey, Amos, additional, Vandoolaeghe, Pascale, additional, Ouedraogo, Florence, additional, Sambian, David, additional, Lievens, Marc, additional, Tahita, Marc Christian, additional, Rettig, Theresa, additional, Jongert, Erik, additional, Lompo, Palpouguini, additional, Idriss, Ali, additional, Borys, Dorota, additional, Ouedraogo, Sayouba, additional, Prempeh, Frank, additional, Habib, Md Ahsan, additional, Schuerman, Lode, additional, Sorgho, Hermann, additional, and Agbenyega, Tsiri, additional

Published
2018
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38. Clinical bacteriology in low-resource settings: today's solutions

Author

Ombelet, Sien, Ronat, Jean Baptiste, Walsh, Timothy T.S., Yansouni, Cedric C.P., Cox, Janneke, Vlieghe, Erika, Martiny, Delphine, Semret, Makeda, Vandenberg, Olivier, Jacobs, Jan Adriaan J., Lunguya, Octavie, Phoba, Marie France, Lompo, Palpouguini, PHE, Thong, KARIUKI, Samuel, NEWTON, Paul P.N., Dance, David Allan Brett, MUVUNYI, Claude, EL SAFI, Sayda, BARBE, Barbara, Falay, Dadi, AFFOLABI, Dissou, PAGE, Maurice, LANGENDORF, Céline, GILLE, Yves, LEENSTRA, Tjalling, STELLING, John, Naas, Thierry, KESTEMAN, Thomas, SEIFU, Daniel, DELAROCQUE-ASTAGNEAU, Elisabeth, SCHULTSZ, Constance, SCHUTT-GEROWITT, Heidi, LETCHFORD, Joanne, WERTHEIM, Heiman, Kahlmeter, Gunnar, AIDARA KANE, Awa, Ombelet, Sien, Ronat, Jean Baptiste, Walsh, Timothy T.S., Yansouni, Cedric C.P., Cox, Janneke, Vlieghe, Erika, Martiny, Delphine, Semret, Makeda, Vandenberg, Olivier, Jacobs, Jan Adriaan J., Lunguya, Octavie, Phoba, Marie France, Lompo, Palpouguini, PHE, Thong, KARIUKI, Samuel, NEWTON, Paul P.N., Dance, David Allan Brett, MUVUNYI, Claude, EL SAFI, Sayda, BARBE, Barbara, Falay, Dadi, AFFOLABI, Dissou, PAGE, Maurice, LANGENDORF, Céline, GILLE, Yves, LEENSTRA, Tjalling, STELLING, John, Naas, Thierry, KESTEMAN, Thomas, SEIFU, Daniel, DELAROCQUE-ASTAGNEAU, Elisabeth, SCHULTSZ, Constance, SCHUTT-GEROWITT, Heidi, LETCHFORD, Joanne, WERTHEIM, Heiman, Kahlmeter, Gunnar, and AIDARA KANE, Awa

Abstract

Low-resource settings are disproportionately burdened by infectious diseases and antimicrobial resistance. Good quality clinical bacteriology through a well functioning reference laboratory network is necessary for effective resistance control, but low-resource settings face infrastructural, technical, and behavioural challenges in the implementation of clinical bacteriology. In this Personal View, we explore what constitutes successful implementation of clinical bacteriology in low-resource settings and describe a framework for implementation that is suitable for general referral hospitals in low-income and middle-income countries with a moderate infrastructure. Most microbiological techniques and equipment are not developed for the specific needs of such settings. Pending the arrival of a new generation diagnostics for these settings, we suggest focus on improving, adapting, and implementing conventional, culture-based techniques. Priorities in low-resource settings include harmonised, quality assured, and tropicalised equipment, consumables, and techniques, and rationalised bacterial identification and testing for antimicrobial resistance. Diagnostics should be integrated into clinical care and patient management; clinically relevant specimens must be appropriately selected and prioritised. Open-access training materials and information management tools should be developed. Also important is the need for onsite validation and field adoption of diagnostics in low-resource settings, with considerable shortening of the time between development and implementation of diagnostics. We argue that the implementation of clinical bacteriology in low-resource settings improves patient management, provides valuable surveillance for local antibiotic treatment guidelines and national policies, and supports containment of antimicrobial resistance and the prevention and control of hospital-acquired infections., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2018

39. The XN-30 Haematology Analyser for Rapid Sensitive Detection of Malaria: A Diagnostic Accuracy Study

Author

Post, Annelies, primary, Kaboré, Berenger, additional, Reuling, Isaie J., additional, Bognini, Joel, additional, van der Heijden, Wouter, additional, Diallo, Salou, additional, Lompo, Palpouguini, additional, Kam, Basile, additional, Herssens, Natacha, additional, Lanke, Kjerstin, additional, Bousema, Teun, additional, Sauerwein, Robert W., additional, Tinto, Halidou, additional, Jacobs, Jan, additional, de Mast, Quirijn, additional, and van der Ven Prof, Andre J., additional

Published
2018
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40. Diagnosis of Bacterial Bloodstream Infections: A 16S Metagenomics Approach

Author

Jessica Maltha, Stijn Deborggraeve, Halidou Tinto, Sandra Van Puyvelde, Conor J. Meehan, Marc Christian Tahita, Tessa De Block, Saskia Decuypere, Jan Jacobs, and Lompo Palpouguini

Subjects
Male, 0301 basic medicine, Bacterial Diseases, Physiology, Bacteremia, Pathology and Laboratory Medicine, Salmonella, RNA, Ribosomal, 16S, Bloodstream infection, Medicine and Health Sciences, RNA RIBOSOMAL 16S, Escherichia Coli, lcsh:Public aspects of medicine, Bacterial Infections, Hematology, Genomics, Body Fluids, Bacterial Pathogens, Blood, Infectious Diseases, Salmonella Enterica, Medical Microbiology, Child, Preschool, Prokaryotic Models, Female, Anatomy, Pathogens, Research Article, DNA, Bacterial, Escherichia, medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, 030106 microbiology, Enterobacter, Biology, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Model Organisms, Enterobacteriaceae, medicine, Genetics, Parasitic Diseases, Humans, Intensive care medicine, Microbial Pathogens, Bacteria, Critically ill, Gut Bacteria, Public Health, Environmental and Occupational Health, Organisms, Infant, Correction, Biology and Life Sciences, Bloodstream Infections, lcsh:RA1-1270, medicine.disease, Tropical Diseases, Malaria, 030104 developmental biology, Metagenomics, Immunology
Abstract

Background Bacterial bloodstream infection (bBSI) is one of the leading causes of death in critically ill patients and accurate diagnosis is therefore crucial. We here report a 16S metagenomics approach for diagnosing and understanding bBSI. Methodology/Principal Findings The proof-of-concept was delivered in 75 children (median age 15 months) with severe febrile illness in Burkina Faso. Standard blood culture and malaria testing were conducted at the time of hospital admission. 16S metagenomics testing was done retrospectively and in duplicate on the blood of all patients. Total DNA was extracted from the blood and the V3–V4 regions of the bacterial 16S rRNA genes were amplified by PCR and deep sequenced on an Illumina MiSeq sequencer. Paired reads were curated, taxonomically labeled, and filtered. Blood culture diagnosed bBSI in 12 patients, but this number increased to 22 patients when combining blood culture and 16S metagenomics results. In addition to superior sensitivity compared to standard blood culture, 16S metagenomics revealed important novel insights into the nature of bBSI. Patients with acute malaria or recovering from malaria had a 7-fold higher risk of presenting polymicrobial bloodstream infections compared to patients with no recent malaria diagnosis (p-value = 0.046). Malaria is known to affect epithelial gut function and may thus facilitate bacterial translocation from the intestinal lumen to the blood. Importantly, patients with such polymicrobial blood infections showed a 9-fold higher risk factor for not surviving their febrile illness (p-value = 0.030). Conclusions/Significance Our data demonstrate that 16S metagenomics is a powerful approach for the diagnosis and understanding of bBSI. This proof-of-concept study also showed that appropriate control samples are crucial to detect background signals due to environmental contamination., Author Summary Bacterial bloodstream infection (bBSI) is one of the biggest causes of mortality in critically ill patients and standard diagnosis is still done by blood culture methods. Parallel deep sequencing of the 16S ribosomal RNA genes (16S metagenomics) is a new and rapidly evolving research field for profiling bacterial communities. We designed a 16S metagenomics approach for the identification of bacteria in the blood of patients with a bBSI, and evaluated its performance in 75 children with severe febrile illness in Burkina Faso. In addition to superior sensitivity compared to standard blood culture, 16S metagenomics revealed important novel insights into the nature of bBSI. Patients with acute malaria or recently recovered from acute malaria are at increased risk of presenting polymicrobial bloodstream infection, which was in itself a significant risk for non-survival. This proof-of-concept study shows that 16S metagenomics is a powerful approach to diagnose and understand bBSI but also that appropriate control samples are crucial for correct data interpretation.

Published
2016

41. Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries

Author

Drakeley, Chris, primary, Abdulla, Salim, additional, Agnandji, Selidji Todagbe, additional, Fernandes, José Francisco, additional, Kremsner, Peter, additional, Lell, Bertrand, additional, Mewono, Ludovic, additional, Bache, Bache Emmanuel, additional, Mihayo, Michael Gabriel, additional, Juma, Omar, additional, Tanner, Marcel, additional, Tahita, Marc Christian, additional, Tinto, Halidou, additional, Diallo, Salou, additional, Lompo, Palpouguini, additional, D’Alessandro, Umberto, additional, Ogutu, Bernhards, additional, Otieno, Lucas, additional, Otieno, Solomon, additional, Otieno, Walter, additional, Oyieko, Janet, additional, Asante, Kwaku Poku, additional, Dery, Dominic Bon-Ereme, additional, Adjei, George, additional, Adeniji, Elisha, additional, Atibilla, Dorcas, additional, Owusu-Agyei, Seth, additional, Greenwood, Brian, additional, Gesase, Samwel, additional, Lusingu, John, additional, Mahende, Coline, additional, Mongi, Robert, additional, Segeja, Method, additional, Adjei, Samuel, additional, Agbenyega, Tsiri, additional, Agyekum, Alex, additional, Ansong, Daniel, additional, Bawa, John Tanko, additional, Boateng, Harry Owusu, additional, Dandalo, Léonard, additional, Escamilla, Veronica, additional, Hoffman, Irving, additional, Maenje, Peter, additional, Martinson, Francis, additional, Carter, Terrell, additional, Leboulleux, Didier, additional, Kaslow, David C., additional, Usuf, Effua, additional, Pirçon, Jean-Yves, additional, and Bahmanyar, Edith Roset, additional

Published
2017
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42. Evaluation of Malaria Screening during Pregnancy with Rapid Diagnostic Tests Performed by Community Health Workers in Burkina Faso

Author

Ruizendaal, Esmée, primary, Scott, Susana, additional, Natama, Hamtandi M., additional, Traore-Coulibaly, Maminata, additional, Valea, Innocent, additional, Bradley, John, additional, Tinto, Halidou, additional, Dierickx, Susan, additional, Mens, Petra F., additional, Drabo, Koiné M., additional, Traore, Ousmane, additional, Pagnoni, Franco, additional, Alessandro, Umberto d’, additional, Schallig, Henk D. F. H., additional, and Lompo, Palpouguini, additional

Published
2017
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43. Accuracy of a Plasmodium falciparum specific histidine-rich protein 2 rapid diagnostic test in the context of the presence of non-malaria fevers, prior anti-malarial use and seasonal malaria transmission

Author

Kiemde, Francois, primary, Bonko, Massa dit Achille, additional, Tahita, Marc Christian, additional, Lompo, Palpouguini, additional, Rouamba, Toussaint, additional, Tinto, Halidou, additional, van Hensbroek, Michael Boele, additional, Mens, Petra F., additional, and Schallig, Henk D. F. H., additional

Published
2017
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44. Population-based incidence, seasonality and serotype distribution of invasive salmonellosis among children in Nanoro, rural Burkina Faso

Author

Guiraud, Issa, primary, Post, Annelies, additional, Diallo, Seydou Nakanabo, additional, Lompo, Palpouguini, additional, Maltha, Jessica, additional, Thriemer, Kamala, additional, Tahita, Christian Marc, additional, Ley, Benedikt, additional, Derra, Karim, additional, Bottieau, Emmanuel, additional, Kazienga, Adama, additional, Schurmans, Céline, additional, Ravinetto, Raffaella, additional, Rouamba, Eli, additional, Van Griensven, Johan, additional, Bertrand, Sophie, additional, Tinto, Halidou, additional, and Jacobs, Jan, additional

Published
2017
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45. Increase in the prevalence of mutations associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates collected from early to late pregnancy in Nanoro, Burkina Faso

Author

Ruizendaal, Esmée, primary, Tahita, Marc C., additional, Geskus, Ronald B., additional, Versteeg, Inge, additional, Scott, Susana, additional, d’Alessandro, Umberto, additional, Lompo, Palpouguini, additional, Derra, Karim, additional, Traore-Coulibaly, Maminata, additional, de Jong, Menno D., additional, Schallig, Henk D. F. H., additional, Tinto, Halidou, additional, and Mens, Petra F., additional

Published
2017
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46. Long-term immunogenicity and immune memory response to the hepatitis B antigen in the RTS,S/AS01Emalaria vaccine in African children: a randomized trial

Author

Valéa, Innocent, Adjei, Samuel, Usuf, Effua, Traore, Ousmane, Ansong, Daniel, Tinto, Halidou, Owusu Boateng, Harry, Some, Athanase Mwinessobaonfou, Buabeng, Patrick, Vekemans, Johan, Kotey, Amos, Vandoolaeghe, Pascale, Cullinane, Mark, Traskine, Magali, Ouedraogo, Florence, Sambian, David, Lievens, Marc, Tahita, Marc Christian, Jongert, Erik, Lompo, Palpouguini, Idriss, Ali, Borys, Dorota, Ouedraogo, Sayouba, Prempeh, Frank, Schuerman, Lode, Sorgho, Hermann, and Agbenyega, Tsiri

Abstract

ABSTRACTRTS,S/AS01Emalaria vaccine contains the hepatitis B virus surface antigen and may thus serve as a potential hepatitis B vaccine. To evaluate the impact of RTS,S/AS01Ewhen implemented in the Expanded Program of Immunization, infants 8–12 weeks old were randomized to receive either RTS,S/AS01Eor a licensed hepatitis B control vaccine (HepB), both co-administered with various combinations of the following childhood vaccines: diphtheria-tetanus-acellular pertussis-Haemophilus influenzaetype b, trivalent oral poliovirus, pneumococcal non-typeable Haemophilus influenzaeprotein D conjugate and human rotavirus vaccine. Long-term persistence of antibodies against the circumsporozoite (CS) protein and hepatitis B surface antigen (HBsAg) were assessed, together with the immune memory response to the HB antigen following a booster dose of HepB vaccine. Subgroups receiving RTS,S or the HepB control vaccine were pooled into RTS,S groups and HepB groups, respectively. One month post-HepB booster vaccination, 100% of participants in the RTS,S groups and 98.3% in the control groups had anti-HBs antibody concentrations ≥10 mIU/mL with the geometric mean concentrations (GMCs) at 46634.7 mIU/mL (95% CI: 40561.3; 53617.6) and 9258.2 mIU/mL (95% CI: 6925.3; 12377.0), respectively. Forty-eight months post-primary vaccination anti-CS antibody GMCs ranged from 2.3 EU/mL to 2.7 EU/mL in the RTS,S groups compared to 1.1 EU/mL in the control groups. Hepatitis B priming with the RTS,S/AS01Evaccine was effective and resulted in a memory response to HBsAg as shown by the robust booster response following an additional dose of HepB vaccine. RTS,S/AS01E when co-administered with PHiD-CV, HRV and other childhood vaccines, had an acceptable safety profile.

Published
2020
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47. Low Birth Weight and Prematurity in Teenage Mothers in Rural Areas of Burkina Faso

Author

UCL - SSS/IREC/EPID - Pôle d'épidémiologie et biostatistique, Bihoun, Biebo, Zango, Serge Henri, Coulibaly, Maminata Traorw, Rouamba, Toussaint, Zemba, Daniel, Tahita, Marc Christian, Yarga, Sibiri, Kabore, Benjamin, Lompo, Palpouguini, Valea, Innocent, Samadoulougou, Sekou Ouindpanga, Ravinetto, Raffaella, Van Geertruyden, Jean Pierre, D Alessandro, Umberto, Tinto, Halidou, Robert , Annie, UCL - SSS/IREC/EPID - Pôle d'épidémiologie et biostatistique, Bihoun, Biebo, Zango, Serge Henri, Coulibaly, Maminata Traorw, Rouamba, Toussaint, Zemba, Daniel, Tahita, Marc Christian, Yarga, Sibiri, Kabore, Benjamin, Lompo, Palpouguini, Valea, Innocent, Samadoulougou, Sekou Ouindpanga, Ravinetto, Raffaella, Van Geertruyden, Jean Pierre, D Alessandro, Umberto, Tinto, Halidou, and Robert , Annie

Published
2017

48. Accuracy of a Plasmodium falciparum specific histidine-rich protein 2 rapid diagnostic test in the context of the presence of non-malaria fevers, prior anti-malarial use and seasonal malaria transmission.

Author

Kiemde, Francois, Bonko, Massa Dit Achille, Tahita, Marc Christian, Lompo, Palpouguini, Rouamba, Toussaint, Tinto, Halidou, van Hensbroek, Michaël Boele, Mens, Petra F, Schallig, Henk HDFH, Kiemde, Francois, Bonko, Massa Dit Achille, Tahita, Marc Christian, Lompo, Palpouguini, Rouamba, Toussaint, Tinto, Halidou, van Hensbroek, Michaël Boele, Mens, Petra F, and Schallig, Henk HDFH

Abstract

It remains challenging to distinguish malaria from other fever causing infections, as a positive rapid diagnostic test does not always signify a true active malaria infection. This study was designed to determine the influence of other causes of fever, prior anti-malarial treatment, and a possible seasonality of the performance of a PfHRP2 RDT for the diagnosis of malaria in children under-5 years of age living in a malaria endemic area., info:eu-repo/semantics/published

Published
2017

49. Low Birth Weight and Prematurity in Teenage Mothers in Rural Areas of Burkina Faso

Author

Bihoun, Biebo, primary, Zango, Serge Henri, additional, Coulibaly, Maminata Traorw, additional, Rouamba, Toussaint, additional, Zemba, Daniel, additional, Tahita, Marc Christian, additional, Yarga, Sibiri, additional, Kabore, Benjamin, additional, Lompo, Palpouguini, additional, Valea, Innocent, additional, Samadoulougou, Sekou Ouindpanga, additional, Ravinetto, Raffaella, additional, Van Geertruyden, Jean Pierre, additional, D Alessandro, Umberto, additional, Tinto, Halidou, additional, and Robert, Annie, additional

Published
2017
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