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129 results on '"Lomet, D."'

11. The kisspeptin analog C6 triggers ovulation in non-breeding ewe in the absence of progestogen priming

Author

Decourt, C., Robert, V., Lomet, D., Aucagne, V., Beltramo, M., Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

Subjects
[CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

12. Rational design of kisspeptin analogs for the control of the reproductive system

Author

Vishwanatha, T.M., Decourt, C., Terrier, V.P., Robert, V., Madinier, J.-B., Marceau, P., Dardente, Hugues, Lomet, D., Delmas, A.F., Caraty, A., Beltramo, Massimiliano, Aucagne, V., Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Recherches Cunicoles (SRC), Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Frapart, Isabelle

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

13. Rational design of kisspeptin analogs for the control of reproduction

Author

Vishwanatha, T.M., Decourt, C., Terrier, V.P., Robert, V., Galibert, M., Madinier, J.-B., Marceau, P., Dardente, Hugues, Lomet, D., Delmas, A.F., Caraty, A., Beltramo, Massimiliano, Aucagne, V., Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Surgery, Faculty of Medicine, Laval University, Québec, Canada, Université Laval [Québec] (ULaval), Recherches Cunicoles (SRC), Institut National de la Recherche Agronomique (INRA), Frapart, Isabelle, Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

14. Long-lasting increase of gonadotropins by rational design of lipophilic kisspeptin analogs

Author

Vishwanatha, T.M., Decourt C, C., Robert, V., Galibert, M., Madinier, J.-B., Marceau, P., Dardente, Hugues, Lomet, D., Delmas, A.F., Caraty, A., Beltramo, Massimiliano, Aucagne, V., Frapart, Isabelle, Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

15. Pattern of LH secretion after repeated treatment with kisspeptin analog C6 reveals differential sensitivity between mice and ewes

Author

Decourt, C., Robert, V., Lomet, D., Anderson, G., Aucagne, Vincent, Beltramo, M., Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Frapart, Isabelle, and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

Modulation of kisspeptin system could be beneficial to treat human infertility as well as to manage reproduction in domestic animals. We developed a series of kisspeptin analogs with improved pharmacological features. The lead compound, C6, triggers fertile ovulation in ewes in both breeding and non-breeding seasons. In addition daily injection of C6 (5X0.15 nmol) in prepubertal female mice from post-natal day 26 to 30 significantly advanced puberty. In thisexperimental setting following 5 daily injection, C6 effect on LH secretion was reduced suggesting a possible desensitization. Desensitization of gonadotrophe cells by continuous stimulation is a feature utilized to treat somehormone dependent cancers such as prostate cancer. Therefore, for field and therapeutic applications it is of paramount importance to identify the dosing regimen necessary to obtained continuous stimulation versus inhibition. We performed an initial experiment in adult mice ovariectomized (OVX) or OVX and replaced with estradiol (+E) to control for E feedback. In OVX+E mice daily injections of C6 (0.1 or 0.4 nmol/mouse ip) for 4 days produced no evidenttachyphylaxis on LH plasma concentration increase. In the OVX mice the basal LH level was already high and C6 injection had minimal if any effect on LH plasma concentration. In both OVX and OVX+E mice, administration of GnRHat the end of the experiment induced a robust LH increase. To evaluate possible difference in species sensibility to repeated treatment we performed a similar experiment in OVX+E ewes. Intramuscular C6 injections were performed at12 or 24-hour intervals (15 nmol/ewe/injection; 6 injections/ewe for the 12 hours and 4 injections/ewe for the 24 hours dosing regimen). Regardless to dosing regimen, the first injection induced an LH increase. However, subsequentinjections had modest or no effect on LH plasma concentration. Injection of GnRH (5 μg) at the end of the 12 hours dosing regimen significantly increased LH. Ongoing experiments aim at evaluating the effect of injections every 36 or48 hours to establish the minimal interval required to obtain repeated stimulation. These results suggest two main conclusions: i) under our experimental conditions the capacity for increased GnRH secretion is the potential limitingrequirement for efficacious repeated C6 treatments; ii) a differential sensitivity to repeated treatment exists between species. Identification of the limiting conditions for sustained LH increase or desensitization will provide relevantinformation for developing field and therapeutic applications but caution should be used in translating information from one species to another.

Published
2017

17. A synthetic kisspeptin analog that triggers ovulation and advances puberty

Author

Decourt, C., primary, Robert, V., additional, Anger, K., additional, Galibert, M., additional, Madinier, J.-B., additional, Liu, X., additional, Dardente, H., additional, Lomet, D., additional, Delmas, A. F., additional, Caraty, A., additional, Herbison, A. E., additional, Anderson, G. M, additional, Aucagne, V., additional, and Beltramo, M., additional

Published
2016
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18. Seasonnality et polymorphism of oMT1 melatonin receptor: Causal relation or simple marker?

Author

Trécherel, E., Collet, A., CHESNEAU, D., Lomet, D., Batailler, M., Duittoz, Anne, Duittoz, A.H., Malpaux, B., Chemineau, Philippe, Migaud, Martine, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), and ProdInra, Migration

Subjects
Genetics, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.SA] Life Sciences [q-bio]/Agricultural sciences, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Endocrine and Autonomic Systems, Causal relations, [SDV]Life Sciences [q-bio], 030209 endocrinology & metabolism, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, Biology, Melatonin receptor, 03 medical and health sciences, 0302 clinical medicine, VATIATION SAISONNIERE, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 10. No inequality, 030217 neurology & neurosurgery, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

19. Using the Lock Manager to Choose Timestamps

Author

Lomet, D., Snodgrass, R.T., and Jensen, Christian Søndergaard

Abstract

Our goal is to support transaction-time functionality that enables the coexistence of ordinary, non-temporal tables with transaction-time tables. In such a system, each transaction updating a transaction-time or snapshot table must include a timestamp for its updated data that correctly reflects the serialization order of the transactions, including transactions on ordinary tables. A serious issue is coping with SQL CURRENT_TIME functions, which should return a time consistent with a transaction's timestamp and serialization order. Prior timestamping techniques cannot support such functions with this desired semantics. We show how to compatibly extend conventional database functionality for transactiontime support by exploiting the database system lock manager and by utilizing a spectrum of optimizations. Our goal is to support transaction-time functionality that enables the coexistence of ordinary, non-temporal tables with transaction-time tables. In such a system, each transaction updating a transaction-time or snapshot table must include a timestamp for its updated data that correctly reflects the serialization order of the transactions, including transactions on ordinary tables. A serious issue is coping with SQL CURRENT_TIME functions, which should return a time consistent with a transaction's timestamp and serialization order. Prior timestamping techniques cannot support such functions with this desired semantics. We show how to compatibly extend conventional database functionality for transactiontime support by exploiting the database system lock manager and by utilizing a spectrum of optimizations.

Published
2005

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