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238 results on '"Lombardini, L."'

7. Organ donation from patients with a rare disease is often safe: the italian guidelines

Author

Dallapiccola, B, Moriconi, S, Rugge, M, Cardillo, M, Carcassi, C, Colledan, M, Strologo, L, Vici, C, Facchin, P, Gridelli, B, La Rocca, V, Lombardini, L, Mazzucato, M, Peritore, D, Amoroso, A, Dallapiccola B., Moriconi S., Rugge M., Cardillo M., Carcassi C., Colledan M., Strologo L. D., Vici C. D., Facchin P., Gridelli B., La Rocca V., Lombardini L., Mazzucato M., Peritore D., Amoroso A., Dallapiccola, B, Moriconi, S, Rugge, M, Cardillo, M, Carcassi, C, Colledan, M, Strologo, L, Vici, C, Facchin, P, Gridelli, B, La Rocca, V, Lombardini, L, Mazzucato, M, Peritore, D, Amoroso, A, Dallapiccola B., Moriconi S., Rugge M., Cardillo M., Carcassi C., Colledan M., Strologo L. D., Vici C. D., Facchin P., Gridelli B., La Rocca V., Lombardini L., Mazzucato M., Peritore D., and Amoroso A.

Abstract

Although a disease is defined as rare when it has a prevalence of less than 1:2000, the overall prevalence of rare diseases in the population is greater than 1%. Among potential organ donors, a similar frequency is observed. To date, guidelines have not been established, and operational decisions have been made empirically, case- by-case, based on the experience and expertise of clinicians. For this reason, the Italian Superior Health Council (CSS) has appointed a working Group to address “patients with a rare disease as potential organ donors,” with the aim of devising recommendations for the management of transplant cases in which the donors have a rare disease. This group evaluated 493 diseases (10% of all rare diseases, including over 95% of patients with a rare disease) to deliver a technical report dealing with the suitability of organ donation and transplantation, with a focus on the organs most frequently used, including kidney, liver, heart, lung, and pancreas. This work has made it clear that a rare disease “per se” does not contraindicate organ donation at all. Indeed, in donors affected by a rare disease, almost 80% of the organs are suitable for transplantation, approximately 7% are unsuitable, and approximately 14% are suitable as non-standard with an acceptable risk.

Published
2022

8. The frequency of rare and monogenic diseases in pediatric organ transplant recipients in Italy

Author

Vaisitti T., Peritore D., Magistroni P., Ricci A., Lombardini L., Gringeri E., Catalano S., Spada M., Sciveres M., Di Giorgio A., Limongelli G., Varrenti M., Gerosa G., Terzi A., Napoleone C. P., Amodeo A., Ragni L., Strologo L., Benetti E., Fontana I., Testa S., Peruzzi L., Mitrotti A., Abbate S., Comai G., Gotti E., Schiavon M., Boffini M., De Angelis D., Bertani A., Pinelli D., Torre M., Poggi C., Deaglio S., Cardillo M., Amoroso A., Serena A., Giorgia C., Vaisitti, T., Peritore, D., Magistroni, P., Ricci, A., Lombardini, L., Gringeri, E., Catalano, S., Spada, M., Sciveres, M., Di Giorgio, A., Limongelli, G., Varrenti, M., Gerosa, G., Terzi, A., Napoleone, C. P., Amodeo, A., Ragni, L., Strologo, L., Benetti, E., Fontana, I., Testa, S., Peruzzi, L., Mitrotti, A., Abbate, S., Comai, G., Gotti, E., Schiavon, M., Boffini, M., De Angelis, D., Bertani, A., Pinelli, D., Torre, M., Poggi, C., Deaglio, S., Cardillo, M., Amoroso, A., Serena, A., and Giorgia, C.

Subjects
Registrie, Pediatrics, medicine.medical_specialty, Transplant outcome, Transplant Recipient, Monogenic diseases, Organ transplantation, Rare diseases, Child, Humans, Italy, Quality of Life, Registries, Transplant Recipients, Kidney Transplantation, Organ Transplantation, Disease, Quality of life, medicine, Pharmacology (medical), Monogenic disease, Genetics (clinical), Lung, business.industry, Research, Liver and kidney, General Medicine, Transplantation, medicine.anatomical_structure, Cohort, Medicine, business, Rare disease, Human
Abstract

Background Rare diseases are chronic and life-threatening disorders affecting Results To the purpose of our analysis, we considered heart, lung, liver and kidney transplants included in the Transplant Registry (TR) of the Italian National Transplantation Center in the 2002–2019 timeframe. Overall, 49,404 recipients were enrolled in the cohort, 5.1% of whom in the pediatric age. For 40,909 (82.8%) transplant recipients, a disease diagnosis was available, of which 38,615 in the adult cohort, while 8,495 patients (17.2%) were undiagnosed. There were 128 disease categories, and of these, 117 were listed in the main rare disease databases. In the pediatric cohort, 2,294 (5.6%) patients had a disease diagnosis: of the 2,126 (92.7%) patients affected by a rare disease, 1,402 (61.1%) presented with a monogenic condition. As expected, the frequencies of pathologies leading to organ failure were different between the pediatric and the adult cohort. Moreover, the pediatric group was characterized, compared to the adult one, by an overall better survival of the graft at ten years after transplant, with the only exception of lung transplants. When comparing survival considering rare vs non-rare diseases or rare and monogenic vs rare non-monogenic conditions, no differences were highlighted for kidney and lung transplants, while rare diseases had a better survival in liver as opposed to heart transplants. Conclusions This work represents the first national survey analyzing the main genetic causes and frequencies of rare and/or monogenic diseases leading to organ failure and requiring transplantation both in adults and children.

Published
2021

16. Outcome of patients activating an unrelated donor search: the impact of transplant with reduced intensity conditioning in a large cohort of consecutive high-risk patients

Author

Rambaldi, A, Bacigalupo, A, Fanin, R, Ciceri, F, Bonifazi, F, Falda, M, Lambertenghi-Deliliers, G, Benedetti, F, Bruno, B, Corradini, P, Alessandrino, P E, Iacopino, P, Arcese, W, Scimè, R, Raimondi, R, Sica, S, Castagna, L, Lamparelli, T, Oneto, R, Lombardini, L, Pollichieni, S, Algarotti, A, Carobbio, A, Sacchi, N, and Bosi, A

Published
2012
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21. Cord blood banking

Author

Brand, A., Rebulla, P., Engelfriet, C. P., Reesink, H. W., Beguin, Y., Baudoux, E., Kögler, G., Ebrahimi, M., Grazzini, G., Costa, A. Nanni, Bosi, A., Sacchi, N., Lombardini, L., Pupella, S., Lecchi, L., Calderón Garcidueñas, E. D., van Beckhoven, J. M., de Wit, H. J. C., Fibbe, W. E., Zhiburt, E. B., Bart, T., Beksaç, M., Navarrete, C., and Regan, F.

Published
2008

29. Social and labor market reintegration of the transplanted patient

Author

Bellis, L., primary, Carella, C., additional, Trerotola, M., additional, Lombardini, L., additional, Sorrentino, E., additional, Melloni, R., additional, Mosconi, G., additional, Sella, G., additional, Mosconi, S., additional, Sangiorgi, G., additional, De Cillia, C., additional, Totti, V., additional, Morelli, M.C., additional, Vero, V., additional, Ermolao, A., additional, Canali, C., additional, Papaleo, B., additional, Costa, A. Nanni, additional, and Cardillo, M., additional

Published
2019
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31. A cost analysis of public cord blood banks belonging to the Italian cord blood network

Author

Pupella, S., Bianchi, M., Ceccarelli, A., Calteri, D., Lombardini, L., Giornetti, A., Marano, G., Franchini, M., Grazzini, G., and Liumbruno, G. M.

Subjects
banking, cord blood, cost analysis, costs, stem cell transplantation, blood banks, blood preservation, costs and cost analysis, cryopreservation, humans, Italy, blood donors, fetal blood
Published
2018

33. West Nile virus transmission: results from the integrated surveillance system in Italy, 2008 to 2015

Author

Rizzo, Caterina, Napoli, Christian, Venturi, G., Pupella, S., Lombardini, L., Calistri, P., Monaco, F., Cagarelli, R., Angelini, P., Bellini, R., Tamba, M., Piatti, A., Russo, F., Palú, G., Chiari, M., Lavazza, A., Bella, A., Maraglino, Francesco, Parodi, Patrizia, Cenci, Corrado, Costa, Nanni, Liumbruno, Giancarlo Maria, Pezzotti, Patrizio, Fortuna, Claudia, Fiorentini, Cristiano, Remoli, Maria Elena, Benedetti, Eleonora, Boccolini, Daniela, di Luca, Marco, Romi, Roberto, Severini, Francesco, Toma, Luciano, Busani, Luca, Declich, Silvia, Rezza, Gianni, Landini, Maria Paola, Bedeschi, Emanuela, Dottori, Michele, Gualanduzzi, Claudio, Lombardini, Annalisa, Mattivi, Andrea, Natalini, Silvano, Squintani, Gabriele, Gismondo, Mariarita, Rovida, Francesca, Zanchetta, Nadia, Rossi, Davide, Baldanti, Fausto, Gramegna, Maria, Farioli, Marco, Lelli, Davide, Prosperi, Alice, Faccin, Francesca, and Zanella, Francesca

Subjects
0301 basic medicine, Zika virus disease, medicine.medical_specialty, Epidemiology, viruses, 030106 microbiology, 030231 tropical medicine, Disease, medicine.disease_cause, Surveillance and Outbreak Report, Dengue fever, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Virology, Environmental health, medicine, Animals, Humans, Organ donation, Chikungunya, Horses, environmental and occupational health, Transmission (medicine), Incidence, public health, Public Health, Environmental and Occupational Health, italy, west nile virus, incidence, integrated surveillance, epidemiology, virology, medicine.disease, Insect Vectors, Geography, Italy, Vector (epidemiology), Population Surveillance, Horse Diseases, Seasons, West Nile virus, Sentinel Surveillance, West Nile Fever
Abstract

In Italy a national Plan for the surveillance of imported and autochthonous human vector-borne diseases (chikungunya, dengue, Zika virus disease and West Nile virus (WNV) disease) that integrates human and veterinary (animals and vectors) surveillance, is issued and revised annually according with the observed epidemiological changes. Here we describe results of the WNV integrated veterinary and human surveillance systems in Italy from 2008 to 2015. A real time data exchange protocol is in place between the surveillance systems to rapidly identify occurrence of human and animal cases and to define and update the map of affected areas i.e. provinces during the vector activity period from June to October. WNV continues to cause severe illnesses in Italy during every transmission season, albeit cases are sporadic and the epidemiology varies by virus lineage and geographic area. The integration of surveillance activities and a multidisciplinary approach made it possible and have been fundamental in supporting implementation of and/or strengthening preventive measures aimed at reducing the risk of transmission of WNV trough blood, tissues and organ donation and to implementing further measures for vector control.

Published
2016

36. Evidence of DMSO-Induced Protein Aggregation in Cells

Author

Giugliarelli, A., primary, Urbanelli, L., additional, Ricci, M., additional, Paolantoni, M., additional, Emiliani, C., additional, Saccardi, R., additional, Mazzanti, B., additional, Lombardini, L., additional, Morresi, A., additional, and Sassi, P., additional

Published
2016
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37. Management of carbapenem resistant Klebsiella pneumoniae infections in stem cell transplant recipients: An italian multidisciplinary consensus statement

Author

Girmenia, C., Viscoli, C., Piciocchi, A., Cudillo, L., Botti, S., Errico, A., Sarmati, L., Ciceri, F., Locatelli, Franco, Giannella, M., Bassetti, M., Tascini, C., Lombardini, L., Majolino, I., Farina, C., Luzzaro, F., Rossolini, G. M., Rambaldi, A., Locatelli F. (ORCID:0000-0002-7976-3654), Girmenia, C., Viscoli, C., Piciocchi, A., Cudillo, L., Botti, S., Errico, A., Sarmati, L., Ciceri, F., Locatelli, Franco, Giannella, M., Bassetti, M., Tascini, C., Lombardini, L., Majolino, I., Farina, C., Luzzaro, F., Rossolini, G. M., Rambaldi, A., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

NO ABSTRACT

Published
2015

38. Management of carbapenem resistant Klebsiella pneumoniae infections in stem cell transplant recipients: an Italian multidisciplinary consensus statement

Author

Girmenia, C., primary, Viscoli, C., additional, Piciocchi, A., additional, Cudillo, L., additional, Botti, S., additional, Errico, A., additional, Sarmati, L., additional, Ciceri, F., additional, Locatelli, F., additional, Giannella, M., additional, Bassetti, M., additional, Tascini, C., additional, Lombardini, L., additional, Majolino, I., additional, Farina, C., additional, Luzzaro, F., additional, Rossolini, G. M., additional, and Rambaldi, A., additional

Published
2015
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43. Fetal striatal grafting slows motor and cognitive decline of Huntington's disease

Author

Paganini, M., primary, Biggeri, A., additional, Romoli, A. M., additional, Mechi, C., additional, Ghelli, E., additional, Berti, V., additional, Pradella, S., additional, Bucciantini, S., additional, Catelan, D., additional, Saccardi, R., additional, Lombardini, L., additional, Mascalchi, M., additional, Massacesi, L., additional, Porfirio, B., additional, Di Lorenzo, N., additional, Vannelli, G. B., additional, and Gallina, P., additional

Published
2013
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