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2. Characteristics and outcomes of patients with tricuspid regurgitation and advanced heart failure

Author

Pagnesi, Matteo, Riccardi, Mauro, Chiarito, Mauro, Stolfo, Davide, Baldetti, Luca, Lombardi, Carlo Mario, Colombo, Giada, Inciardi, Riccardo Maria, Tomasoni, Daniela, Loiacono, Ferdinando, Maccallini, Marta, Villaschi, Alessandro, Gasparini, Gaia, Montella, Marco, Contessi, Stefano, Cocianni, Daniele, Perotto, Maria, Barone, Giuseppe, Merlo, Marco, Cappelletti, Alberto Maria, Sinagra, Gianfranco, Pini, Daniela, Metra, Marco, and Adamo, Marianna

Published
2024
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4. Clinical and prognostic implications of heart failure hospitalization in patients with advanced heart failure

Author

Pagnesi, Matteo, Sammartino, Antonio Maria, Chiarito, Mauro, Stolfo, Davide, Baldetti, Luca, Adamo, Marianna, Maggi, Giuseppe, Inciardi, Riccardo Maria, Tomasoni, Daniela, Loiacono, Ferdinando, Maccallini, Marta, Villaschi, Alessandro, Gasparini, Gaia, Montella, Marco, Contessi, Stefano, Cocianni, Daniele, Perotto, Maria, Barone, Giuseppe, Merlo, Marco, Cappelletti, Alberto Maria, Sinagra, Gianfranco, Pini, Daniela, Metra, Marco, and Lombardi, Carlo Mario

Published
2024
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5. Detailed Assessment of the “I Need Help” Criteria in Patients With Heart Failure: Insights From the HELP-HF Registry

Author

Pagnesi, Matteo, Ghiraldin, Daniele, Vizzardi, Enrico, Chiarito, Mauro, Stolfo, Davide, Baldetti, Luca, Adamo, Marianna, Lombardi, Carlo Mario, Inciardi, Riccardo Maria, Tomasoni, Daniela, Loiacono, Ferdinando, Maccallini, Marta, Villaschi, Alessandro, Gasparini, Gaia, Montella, Marco, Contessi, Stefano, Cocianni, Daniele, Perotto, Maria, Barone, Giuseppe, Sartori, Samantha, Davison, Beth A., Merlo, Marco, Cappelletti, Alberto Maria, Sinagra, Gianfranco, Pini, Daniela, and Metra, Marco

Published
2023
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6. Ischemic Etiology in Advanced Heart Failure: Insight from the HELP-HF Registry

Author

Villaschi, Alessandro, Pagnesi, Matteo, Stolfo, Davide, Baldetti, Luca, Lombardi, Carlo Mario, Adamo, Marianna, Loiacono, Ferdinando, Sammartino, Antonio Maria, Colombo, Giada, Tomasoni, Daniela, Inciardi, Riccardo Maria, Maccallini, Marta, Gasparini, Gaia, Montella, Marco, Contessi, Stefano, Cocianni, Daniele, Perotto, Maria, Barone, Giuseppe, Merlo, Marco, Cappelletti, Alberto Maria, Sinagra, Gianfranco, Pini, Daniela, Metra, Marco, and Chiarito, Mauro

Published
2023
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7. Performance of risk stratification scores and role of comorbidities in older vs younger patients with pulmonary arterial hypertension

Author

Stolfo, Davide, Barbisan, Davide, Ameri, Pietro, Lombardi, Carlo Mario, Monti, Simonetta, Driussi, Mauro, Zovatto, Isabella Carlotta, Gentile, Piero, Howard, Luke, Toma, Matteo, Pagnesi, Matteo, Collini, Valentino, Bauleo, Carolina, Guglielmi, Giulia, Adamo, Marianna, D'Angelo, Luciana, Nalli, Chiara, Sciarrone, Paolo, Moschella, Martina, Zorzi, Barbara, Vecchiato, Veronica, Milani, Martina, Di Poi, Emma, Airò, Edoardo, Metra, Marco, Garascia, Andrea, Sinagra, Gianfranco, and Lo Giudice, Francesco

Published
2023
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11. 2024 update in heart failure

Author

Beghini, Alberto, primary, Sammartino, Antonio Maria, additional, Papp, Zoltán, additional, von Haehling, Stephan, additional, Biegus, Jan, additional, Ponikowski, Piotr, additional, Adamo, Marianna, additional, Falco, Luigi, additional, Lombardi, Carlo Mario, additional, Pagnesi, Matteo, additional, Savarese, Gianluigi, additional, Metra, Marco, additional, and Tomasoni, Daniela, additional

Published
2024
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12. Frailty according to the 2019 HFA‐ESC definition in patients at risk for advanced heart failure: Insights from the HELP‐HF registry

Author

Villaschi, Alessandro, primary, Chiarito, Mauro, additional, Pagnesi, Matteo, additional, Stolfo, Davide, additional, Baldetti, Luca, additional, Lombardi, Carlo Mario, additional, Adamo, Marianna, additional, Loiacono, Ferdinando, additional, Sammartino, Antonio Maria, additional, Colombo, Giada, additional, Tomasoni, Daniela, additional, Inciardi, Riccardo Maria, additional, Maccallini, Marta, additional, Gasparini, Gaia, additional, Montella, Marco, additional, Contessi, Stefano, additional, Cocianni, Daniele, additional, Perotto, Maria, additional, Barone, Giuseppe, additional, Merlo, Marco, additional, Vitale, Cristiana, additional, Rosano, Giuseppe Massimo Claudio, additional, Cappelletti, Alberto Maria, additional, Sinagra, Gianfranco, additional, Metra, Marco, additional, and Pini, Daniela, additional

Published
2024
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13. Prevalence and clinical outcomes of isolated or combined moderate to severe mitral and tricuspid regurgitation in patients with cardiac amyloidosis.

Author

Tomasoni, Daniela, Aimo, Alberto, Porcari, Aldostefano, Bonfioli, Giovanni Battista, Castiglione, Vincenzo, Saro, Riccardo, Pasquale, Mattia Di, Franzini, Maria, Fabiani, Iacopo, Lombardi, Carlo Mario, Lupi, Laura, Mazzotta, Marta, Nardi, Matilde, Pagnesi, Matteo, Panichella, Giorgia, Rossi, Maddalena, Vergaro, Giuseppe, Merlo, Marco, Sinagra, Gianfranco, and Emdin, Michele

Subjects
CARDIOMYOPATHIES, AMYLOIDOSIS, TREATMENT effectiveness, HEART valve diseases, DESCRIPTIVE statistics, MITRAL valve insufficiency, COMPARATIVE studies, TRICUSPID valve diseases, ECHOCARDIOGRAPHY, EVALUATION
Abstract

Aims Evidence on the epidemiology and prognostic significance of mitral regurgitation (MR) and tricuspid regurgitation (TR) in patients with cardiac amyloidosis (CA) is scarce. Methods and results Overall, 538 patients with either transthyretin (ATTR, n = 359) or immunoglobulin light-chain (AL, n = 179) CA were included at three Italian referral centres. Patients were stratified according to isolated or combined moderate/severe MR and TR. Overall, 240 patients (44.6%) had no significant MR/TR, 112 (20.8%) isolated MR, 66 (12.3%) isolated TR, and 120 (22.3%) combined MR/TR. The most common aetiologies were atrial functional MR, followed by primary infiltrative MR, and secondary TR due to right ventricular (RV) overload followed by atrial functional TR. Patients with isolated or combined MR/TR had a more frequent history of heart failure (HF) hospitalization and atrial fibrillation, worse symptoms, and higher levels of NT-proBNP as compared to those without MR/TR. They also presented more severe atrial enlargement, atrial peak longitudinal strain impairment, left ventricular (LV) and RV systolic dysfunction, and higher pulmonary artery systolic pressures. TR carried the most advanced features. After adjustment for age, sex, CA subtypes, laboratory, and echocardiographic markers of CA severity, isolated TR and combined MR/TR were independently associated with an increased risk of all-cause death or worsening HF events, compared to no significant MR/TR [adjusted HR 2.75 (1.78–4.24) and 2.31 (1.44–3.70), respectively]. Conclusion In a large cohort of patients with CA, MR, and TR were common. Isolated TR and combined MR/TR were associated with worse prognosis regardless of CA aetiology, LV, and RV function, with TR carrying the highest risk. [ABSTRACT FROM AUTHOR]

Published
2024
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16. CARDIAC BIOMARKERS AND MORTALITY IN COVID-19 INFECTION: A REVIEW

Author

Cersosimo, Angelica, primary, Cimino, Giuliana, additional, Pascariello, Greta, additional, amore, ludovica, additional, alghisi, fabio, additional, Pancaldi, Edoardo, additional, Bernardi, Nicola, additional, Inciardi, Riccardo, additional, vizzardi, enrico, additional, lombardi, carlo mario, additional, and metra, marco, additional

Published
2024
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18. Pulmonary embolism in patients with COVID-19: characteristics and outcomes in the Cardio-COVID Italy multicenter study

Author

Ameri, Pietro, Inciardi, Riccardo M., Di Pasquale, Mattia, Agostoni, Piergiuseppe, Bellasi, Antonio, Camporotondo, Rita, Canale, Claudia, Carubelli, Valentina, Carugo, Stefano, Catagnano, Francesco, Danzi, Giambattista, Dalla Vecchia, Laura, Giovinazzo, Stefano, Gnecchi, Massimiliano, Guazzi, Marco, Iorio, Anita, La Rovere, Maria Teresa, Leonardi, Sergio, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Merlo, Marco, Monzo, Luca, Mortara, Andrea, Nuzzi, Vincenzo, Piepoli, Massimo, Porto, Italo, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Sinagra, Gianfranco, Tedino, Chiara, Tomasoni, Daniela, Volterrani, Maurizio, Zaccone, Gregorio, Lombardi, Carlo Mario, Senni, Michele, and Metra, Marco

Published
2021
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20. Machine learning for prediction of in-hospital mortality in coronavirus disease 2019 patients: results from an Italian multicenter study

Author

Vezzoli, Marika, Inciardi, Riccardo Maria, Oriecuia, Chiara, Paris, Sara, Murillo, Natalia Herrera, Agostoni, Piergiuseppe, Ameri, Pietro, Bellasi, Antonio, Camporotondo, Rita, Canale, Claudia, Carubelli, Valentina, Carugo, Stefano, Catagnano, Francesco, Danzi, Giambattista, Dalla Vecchia, Laura, Giovinazzo, Stefano, Gnecchi, Massimiliano, Guazzi, Marco, Iorio, Anita, La Rovere, Maria Teresa, Leonardi, Sergio, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Merlo, Marco, Monzo, Luca, Mortara, Andrea, Nuzzi, Vincenzo, Pagnesi, Matteo, Piepoli, Massimo, Porto, Italo, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Senni, Michele, Sinagra, Gianfranco, Tomasoni, Daniela, Adamo, Marianna, Volterrani, Maurizio, Maroldi, Roberto, Metra, Marco, Lombardi, Carlo Mario, and Specchia, Claudia

Published
2022
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21. Sex-related differences in patients with coronavirus disease 2019: results of the Cardio-COVID-Italy multicentre study

Author

Lombardi, Carlo Mario, Specchia, Claudia, Conforti, Fabio, Rovere, Maria Teresa La, Carubelli, Valentina, Agostoni, Piergiuseppe, Carugo, Stefano, Danzi, Gian Battista, Guazzi, Marco, Mortara, Andrea, Piepoli, Massimo, Porto, Italo, Sinagra, Gianfranco, Volterrani, Maurizio, Ameri, Pietro, Gnecchi, Massimiliano, Leonardi, Sergio, Merlo, Marco, Iorio, Annamaria, Bellasi, Antonio, Canale, Claudia, Camporotondo, Rita, Catagnano, Francesco, Dalla Vecchia, Laura Adelaide, Di Pasquale, Mattia, Giovinazzo, Stefano, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Monzo, Luca, Nuzzi, Vincenzo, Oriecuia, Chiara, Pala, Laura, Peveri, Giulia, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Adamo, Marianna, Tomasoni, Daniela, Inciardi, Riccardo Maria, Senni, Michele, and Metra, Marco

Published
2022
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22. Clinical and prognostic implications of heart failure hospitalization in patients with advanced heart failure

Author

Pagnesi, Matteo, primary, Sammartino, Antonio Maria, additional, Chiarito, Mauro, additional, Stolfo, Davide, additional, Baldetti, Luca, additional, Adamo, Marianna, additional, Maggi, Giuseppe, additional, Inciardi, Riccardo Maria, additional, Tomasoni, Daniela, additional, Loiacono, Ferdinando, additional, Maccallini, Marta, additional, Villaschi, Alessandro, additional, Gasparini, Gaia, additional, Montella, Marco, additional, Contessi, Stefano, additional, Cocianni, Daniele, additional, Perotto, Maria, additional, Barone, Giuseppe, additional, Merlo, Marco, additional, Cappelletti, Alberto Maria, additional, Sinagra, Gianfranco, additional, Pini, Daniela, additional, Metra, Marco, additional, and Lombardi, Carlo Mario, additional

Published
2023
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23. Guideline‐directed medical therapy in severe heart failure with reduced ejection fraction: an analysis from the HELP‐HF registry

Author

Tomasoni, Daniela, primary, Pagnesi, Matteo, additional, Colombo, Giada, additional, Chiarito, Mauro, additional, Stolfo, Davide, additional, Baldetti, Luca, additional, Lombardi, Carlo Mario, additional, Adamo, Marianna, additional, Maggi, Giuseppe, additional, Inciardi, Riccardo Maria, additional, Loiacono, Ferdinando, additional, Maccallini, Marta, additional, Villaschi, Alessandro, additional, Gasparini, Gaia, additional, Montella, Marco, additional, Contessi, Stefano, additional, Cocianni, Daniele, additional, Perotto, Maria, additional, Barone, Giuseppe, additional, Merlo, Marco, additional, Cappelletti, Alberto Maria, additional, Rosano, Giuseppe, additional, Sinagra, Gianfranco, additional, Pini, Daniela, additional, Savarese, Gianluigi, additional, and Metra, Marco, additional

Published
2023
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24. Sodium glucose co-transporter 2 inhibitors and quality of life in patients with heart failure: a comprehensive systematic review and meta-analysis of randomized controlled trials

Author

Oriecuia, Chiara, primary, Tomasoni, Daniela, additional, Sala, Isabella, additional, Bonfioli, Giovanni Battista, additional, Adamo, Marianna, additional, Gussago, Cristina, additional, Lombardi, Carlo Mario, additional, Pagnesi, Matteo, additional, Savarese, Gianluigi, additional, Metra, Marco, additional, and Specchia, Claudia, additional

Published
2023
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25. Clinical burden and predictors of non-cardiovascular mortality and morbidity in advanced heart failure

Author

Stolfo, Davide, primary, Pagnesi, Matteo, additional, Chiarito, Mauro, additional, Baldetti, Luca, additional, Merlo, Marco, additional, Lombardi, Carlo Mario, additional, Loiacono, Ferdinando, additional, Cappelletti, Alberto Maria, additional, Contessi, Stefano, additional, Cocianni, Daniele, additional, Perotto, Maria, additional, Adamo, Marianna, additional, Calì, Filippo, additional, Inciardi, Riccardo Maria, additional, Tomasoni, Daniela, additional, Maccallini, Marta, additional, Villaschi, Alessandro, additional, Gasparini, Gaia, additional, Montella, Marco, additional, Barone, Giuseppe, additional, Pini, Daniela, additional, Metra, Marco, additional, and Sinagra, Gianfranco, additional

Published
2023
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26. Role of ejection fraction in patients at risk for advanced heart failure: insights from the HELP‐HF registry

Author

Pagnesi, Matteo, primary, Lombardi, Carlo Mario, additional, Tedino, Chiara, additional, Chiarito, Mauro, additional, Stolfo, Davide, additional, Baldetti, Luca, additional, Adamo, Marianna, additional, Calì, Filippo, additional, Inciardi, Riccardo Maria, additional, Tomasoni, Daniela, additional, Loiacono, Ferdinando, additional, Maccallini, Marta, additional, Villaschi, Alessandro, additional, Gasparini, Gaia, additional, Montella, Marco, additional, Contessi, Stefano, additional, Cocianni, Daniele, additional, Perotto, Maria, additional, Barone, Giuseppe, additional, Merlo, Marco, additional, Cappelletti, Alberto Maria, additional, Sinagra, Gianfranco, additional, Pini, Daniela, additional, and Metra, Marco, additional

Published
2023
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29. Role of ejection fraction in patients at risk for advanced heart failure: insights from the HELP‐HF registry.

Author

Pagnesi, Matteo, Lombardi, Carlo Mario, Tedino, Chiara, Chiarito, Mauro, Stolfo, Davide, Baldetti, Luca, Adamo, Marianna, Calì, Filippo, Inciardi, Riccardo Maria, Tomasoni, Daniela, Loiacono, Ferdinando, Maccallini, Marta, Villaschi, Alessandro, Gasparini, Gaia, Montella, Marco, Contessi, Stefano, Cocianni, Daniele, Perotto, Maria, Barone, Giuseppe, and Merlo, Marco

Subjects
VENTRICULAR ejection fraction, HEART failure, HEART failure patients, RENIN-angiotensin system, CARDIOVASCULAR disease related mortality
Abstract

Aims: Patients with heart failure (HF) with reduced ejection fraction (EF) (HFrEF), mildly reduced EF (HFmrEF), and preserved EF (HFpEF) may all progress to advanced HF, but the impact of EF in the advanced setting is not well established. Our aim was to assess the prognostic impact of EF in patients with at least one 'I NEED HELP' marker for advanced HF. Methods and results: Patients with HF and at least one high‐risk 'I NEED HELP' criterion from four centres were included in this analysis. Outcomes were assessed in patients with HFrEF (EF ≤ 40%), HFmrEF (EF 41–49%), and HFpEF (EF ≥ 50%) and with EF analysed as a continuous variable. The prognostic impact of medical therapy for HF in patients with EF < 50% and EF > 50% was also evaluated. All‐cause death was the primary endpoint, and cardiovascular death was a secondary endpoint. Among 1149 patients enrolled [mean age 75.1 ± 11.5 years, 67.3% males, 67.6% hospitalized, median follow‐up 260 days (inter‐quartile range 105–390 days)], HFrEF, HFmrEF, and HFpEF were observed in 699 (60.8%), 122 (10.6%), and 328 (28.6%) patients, and 1 year mortality was 28.3%, 26.2%, and 20.1, respectively (log‐rank P = 0.036). As compared with HFrEF patients, HFpEF patients had a lower risk of all‐cause death [adjusted hazard ratio (HRadj) 0.67, 95% confidence interval (CI) 0.48–0.94, P = 0.022], whereas no difference was noted for HFmrEF patients. After multivariable adjustment, a lower risk of all‐cause death (HRadj for 5% increase 0.94, 95% CI 0.89–0.99, P = 0.017) and cardiovascular death (HRadj for 5% increase 0.94, 95% CI 0.88–1.00, P = 0.049) was observed at higher EF values. Beta‐blockers and renin–angiotensin system inhibitors or sacubitril/valsartan were associated with lower mortality in both EF < 50% and EF ≥ 50% groups. Conclusions: Among patients with HF and at least one 'I NEED HELP' marker for advanced HF, left ventricular EF is still of prognostic value. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Guideline‐directed medical therapy in severe heart failure with reduced ejection fraction: An analysis from the HELP‐HF registry.

Author

Tomasoni, Daniela, Pagnesi, Matteo, Colombo, Giada, Chiarito, Mauro, Stolfo, Davide, Baldetti, Luca, Lombardi, Carlo Mario, Adamo, Marianna, Maggi, Giuseppe, Inciardi, Riccardo Maria, Loiacono, Ferdinando, Maccallini, Marta, Villaschi, Alessandro, Gasparini, Gaia, Montella, Marco, Contessi, Stefano, Cocianni, Daniele, Perotto, Maria, Barone, Giuseppe, and Merlo, Marco

Subjects
HEART failure, VENTRICULAR ejection fraction, ANGIOTENSIN receptors, ACE inhibitors, ANGIOTENSIN-receptor blockers, HEART failure patients
Abstract

Aim: Persistent symptoms despite guideline‐directed medical therapy (GDMT) and poor tolerance of GDMT are hallmarks of patients with advanced heart failure (HF) with reduced ejection fraction (HFrEF). However, real‐world data on GDMT use, dose, and prognostic implications are lacking. Methods and results: We included 699 consecutive patients with HFrEF and at least one 'I NEED HELP' marker for advanced HF enrolled in a multicentre registry. Beta‐blockers (BB) were administered to 574 (82%) patients, angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers or angiotensin receptor–neprilysin inhibitors (ACEi/ARB/ARNI) were administered to 381 (55%) patients and 416 (60%) received mineralocorticoid receptor antagonists (MRA). Overall, ≥50% of target doses were reached in 41%, 22%, and 56% of the patients on BB, ACEi/ARB/ARNI and MRA, respectively. Hypotension, bradycardia, kidney dysfunction and hyperkalaemia were the main causes of underprescription and/or underdosing, but up to a half of the patients did not receive target doses for unknown causes (51%, 41%, and 55% for BB, ACEi/ARB/ARNI and MRA, respectively). The proportions of patients receiving BB and ACEi/ARB/ARNI were lower among those fulfilling the 2018 HFA‐ESC criteria for advanced HF. Treatment with BB and ACEi/ARB/ARNI were associated with a lower risk of death or HF hospitalizations (adjusted hazard ratio [HR] 0.63, 95% confidence interval [CI] 0.48–0.84, and HR 0.74, 95% CI 0.58–0.95, respectively). Conclusions: In a large, real‐world, contemporary cohort of patients with severe HFrEF, with at least one marker for advanced HF, prescription and uptitration of GDMT remained limited. A significant proportion of patients were undertreated due to unknown reasons suggesting a potential role of clinical inertia either by the prescribing healthcare professional or by the patient. Treatment with BB and ACEi/ARB/ARNI was associated with lower mortality/morbidity. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Haemodynamic forces predicting remodelling and outcome in patients with heart failure treated with sacubitril/valsartan

Author

Fabiani, Iacopo, primary, Pugliese, Nicola Riccardo, additional, Pedrizzetti, Gianni, additional, Tonti, Giovanni, additional, Castiglione, Vincenzo, additional, Chubuchny, Vladislav, additional, Taddei, Claudia, additional, Gimelli, Alessia, additional, Del Punta, Lavinia, additional, Balletti, Alessio, additional, Del Franco, Annamaria, additional, Masi, Stefano, additional, Lombardi, Carlo Mario, additional, Cameli, Matteo, additional, Emdin, Michele, additional, and Giannoni, Alberto, additional

Published
2023
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32. Echocardiographic findings in subjects with an amyloidogenic apolipoprotein A1 pathogenic variant

Author

Tomasoni, Daniela, Aimo, Alberto, Adamo, Marianna, Nardi, Matilde, Lombardi, Carlo Mario, Regazzoni, Valentina, De Angelis, Maria Grazia, Fabiani, Iacopo, Merlini, Giampaolo, Mussinelli, Roberta, Obici, Laura, Panichella, Giorgia, Vergaro, Giuseppe, Passino, Claudio, Scolari, Francesco, Perlini, Stefano, Emdin, Michele, and Metra, Marco

Subjects
cardiac disease, ApoA1, Amyloidosis, apolipoprotein, echocardiography, Internal Medicine
Abstract

Very small case series of patients with apolipoprotein A1 (ApoA1) amyloidosis are available. We described the clinical and echocardiographic characteristics of individuals with the pathogenic APOA1 variant Leu75Pro (p. Leu99Pro), referred for cardiac screening. We enrolled 189 subjects, 54% men, median age 55 years (interquartile range 42–67), 39% with concomitant renal disease and 31% with liver disease. Median left ventricular ejection fraction was 60% (55–66). Overall, these subjects did not show overt diastolic dysfunction nor left ventricular (LV) hypertrophy. Age correlated with interventricular septal (IVS) thickness (r = 0.484), LV mass index (r = 0.459), E/e’ (r = 0.501), and right ventricular free wall thickness (r = 0.594) (all p < 0.001). Some individuals displayed red flags for cardiac amyloidosis (CA), and 14% met non-invasive criteria for CA. Twenty-nine subjects died over 5.8 years (4.1–8.0), with 10 deaths for cardiovascular causes. Individuals meeting echocardiographic criteria for CA had a much higher risk of all-cause death (p = 0.009), cardiovascular death (p = 0.001), cardiovascular death or heart failure (HF) hospitalisation (p < 0.001). Subjects with both renal and liver involvement had a more prominent cardiac involvement, and shortest survival. Subjects with the APOA1 Leu75Pro variant displayed minor echocardiographic signs of cardiac involvement, but 14% met echocardiographic criteria for CA. Subjects with suspected CA had a worse outcome.

Published
2023

33. Left ventricular wall thickness and severity of cardiac disease in women and men with transthyretin amyloidosis

Author

Aimo, Alberto, Tomasoni, Daniela, Porcari, Aldostefano, Vergaro, Giuseppe, Castiglione, Vincenzo, Passino, Claudio, Adamo, Marianna, Bellicini, Maria Giulia, Lombardi, Carlo Mario, Nardi, Matilde, Palamara, Gloria, Varrà, Guerino Giuseppe, Saro, Riccardo, Allegro, Valentina, Merlo, Marco, Sinagra, Gianfranco, Metra, Marco, Emdin, Michele, Rapezzi, Claudio, Aimo, Alberto, Tomasoni, Daniela, Porcari, Aldostefano, Vergaro, Giuseppe, Castiglione, Vincenzo, Passino, Claudio, Adamo, Marianna, Bellicini, Maria Giulia, Lombardi, Carlo Mario, Nardi, Matilde, Palamara, Gloria, Varrà, Guerino Giuseppe, Saro, Riccardo, Allegro, Valentina, Merlo, Marco, Sinagra, Gianfranco, Metra, Marco, Emdin, Michele, and Rapezzi, Claudio

Subjects
Wall thickness, Diagnosis, Amyloidosi, Gender difference, Cut-off, Gender differences, Amyloidosis, Transthyretin, Cardiology and Cardiovascular Medicine, Diagnosi
Abstract

Aims: Cardiac amyloidosis (CA) is due to a deposition of amyloid fibrils in the heart causing an increase in wall thickness. A left ventricular (LV) wall thickness ≥12 mm plus at least one red flag should raise the suspicion of CA. As normal values of LV wall thickness are lower in women, the adoption or the same cut-off values for men and women could lead to underdiagnosis or delayed diagnosis in women. We investigated the relationship between LV wall thickness and the severity of cardiac involvement in women and men with transthyretin (ATTR) CA. Methods and results: We evaluated 330 consecutive patients diagnosed with ATTR-CA at three centres (Pisa, n = 232; Brescia, n = 69; Trieste, n = 29). Interventricular septum (IVS) and posterior wall (PW) thickness values were lower in women (n = 53, 16%) than men, but most differences were abolished when indexing by body surface area (BSA), height, or height, suggesting similar disease severity when accounting for the smaller body size of women. PW thickness indexed for height was even higher in women. We also searched for correlations between IVS and PW thickness and other indicators of the severity of cardiac disease. IVS values indexed by height displayed tighter associations with N-terminal pro-B-type natriuretic peptide values than non-indexed IVS values. Similarly, indexed values displayed closer relationships with relative wall thickness, E/e' ratio, and tricuspid annular plane systolic excursion. Conclusions: Indexed LV wall thickness values, particularly by height, reflect more accurately the severity of cardiac involvement than non-indexed values.

Published
2023

34. Right ventricular to pulmonary artery coupling and outcome in patients with cardiac amyloidosis

Author

Tomasoni, Daniela, primary, Adamo, Marianna, additional, Porcari, Aldostefano, additional, Aimo, Alberto, additional, Bonfioli, Giovanni Battista, additional, Castiglione, Vincenzo, additional, Franzini, Maria, additional, Inciardi, Riccardo Maria, additional, Khalil, Anas, additional, Lombardi, Carlo Mario, additional, Lupi, Laura, additional, Nardi, Matilde, additional, Oriecuia, Chiara, additional, Pagnesi, Matteo, additional, Panichella, Giorgia, additional, Rossi, Maddalena, additional, Saccani, Nicola, additional, Specchia, Claudia, additional, Vergaro, Giuseppe, additional, Merlo, Marco, additional, Sinagra, Gianfranco, additional, Emdin, Michele, additional, and Metra, Marco, additional

Published
2023
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35. Treating amyloid transthyretin cardiomyopathy: lessons learned from clinical trials

Author

Tomasoni, Daniela, primary, Bonfioli, Giovanni Battista, additional, Aimo, Alberto, additional, Adamo, Marianna, additional, Canepa, Marco, additional, Inciardi, Riccardo M., additional, Lombardi, Carlo Mario, additional, Nardi, Matilde, additional, Pagnesi, Matteo, additional, Riccardi, Mauro, additional, Vergaro, Giuseppe, additional, Vizzardi, Enrico, additional, Emdin, Michele, additional, and Metra, Marco, additional

Published
2023
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36. Prognostic value of right ventricular longitudinal strain in patients with secondary mitral regurgitation undergoing transcatheter edge-to-edge mitral valve repair

Author

Lupi, Laura, primary, Italia, Leonardo, additional, Pagnesi, Matteo, additional, Pancaldi, Edoardo, additional, Ancona, Francesco, additional, Stella, Stefano, additional, Pezzola, Elisa, additional, Cimino, Giuliana, additional, Saccani, Nicola, additional, Ingallina, Giacomo, additional, Margonato, Davide, additional, Inciardi, Riccardo Maria, additional, Lombardi, Carlo Mario, additional, Tomasoni, Daniela, additional, Agricola, Eustachio, additional, Metra, Marco, additional, and Adamo, Marianna, additional

Published
2023
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40. Left ventricular wall thickness and severity of cardiac disease in women and men with transthyretin amyloidosis

Author

Aimo, Alberto, primary, Tomasoni, Daniela, additional, Porcari, Aldostefano, additional, Vergaro, Giuseppe, additional, Castiglione, Vincenzo, additional, Passino, Claudio, additional, Adamo, Marianna, additional, Bellicini, Maria Giulia, additional, Lombardi, Carlo Mario, additional, Nardi, Matilde, additional, Palamara, Gloria, additional, Varrà, Guerino Giuseppe, additional, Saro, Riccardo, additional, Allegro, Valentina, additional, Merlo, Marco, additional, Sinagra, Gianfranco, additional, Metra, Marco, additional, Emdin, Michele, additional, and Rapezzi, Claudio, additional

Published
2023
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41. Right ventricular to pulmonary artery coupling and outcome in patients with cardiac amyloidosis

Author

Tomasoni, Daniela, Adamo, Marianna, Porcari, Aldostefano, Aimo, Alberto, Bonfioli, Giovanni Battista, Castiglione, Vincenzo, Franzini, Maria, Inciardi, Riccardo Maria, Khalil, Anas, Lombardi, Carlo Mario, Lupi, Laura, Nardi, Matilde, Oriecuia, Chiara, Pagnesi, Matteo, Panichella, Giorgia, Rossi, Maddalena, Saccani, Nicola, Specchia, Claudia, Vergaro, Giuseppe, Merlo, Marco, Sinagra, Gianfranco, Emdin, Michele, and Metra, Marco

Subjects
right ventricular function, TAPSE/PASP, cardiac amyloidosis, heart failure, prognosis, right ventricular to pulmonary artery coupling
Published
2023

42. 152 PERFORMANCE OF RISK STRATIFICATION SCORES AND ROLE OF COMORBIDITIES IN OLDER VS YOUNGER PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION

Author

Stolfo, Davide, primary, Barbisan, Davide, additional, Ameri, Pietro, additional, Lombardi, Carlo Mario, additional, Monti, Simonetta, additional, Driussi, Mauro, additional, Zovatto, Isabella Carlotta, additional, Gentile, Piero, additional, Howard, Luke, additional, Toma, Matteo, additional, Pagnesi, Matteo, additional, Collini, Valentino, additional, Bauleo, Carolina, additional, Guglielmi, Giulia, additional, Adamo, Marianna, additional, D´angelo, Luciana, additional, Nalli, Chiara, additional, Sciarrone, Paolo, additional, Moschella, Martina, additional, Zorzi, Barbara, additional, Vecchiato, Veronica, additional, Milani, Martina, additional, Poi, Emma Di, additional, Airò, Edoardo, additional, Metra, Marco, additional, Garascia, Andrea, additional, Sinagra, Gianfranco, additional, and Giudice, Francesco Lo, additional

Published
2022
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43. 226 ECHOCARDIOGRAPHIC AND INVASIVE EVALUATION OF LEFT ATRIAL PRESSURE IN PATIENTS UNDERGOING CATHETER ABLATION FOR ATRIAL FIBRILLATION

Author

Bonelli, Andrea, primary, Inciardi, Riccardo Maria, additional, Cersosimo, Angelica, additional, Dell´era, Gabriele, additional, Degiovanni, Anna, additional, Spinoni, Enrico, additional, Bosco, Manuel, additional, Arabia, Gianmarco, additional, Salghetti, Francesca, additional, Bellicini, Mariagiulia, additional, Brangi, Elisa, additional, Legati, Michele, additional, Pagnesi, Matteo, additional, Lombardi, Carlo Mario, additional, Curnis, Antonio, additional, Patti, Giuseppe, additional, and Metra, Marco, additional

Published
2022
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44. 247 HEPATIC T1-TIME, CARDIAC STRUCTURE, FUNCTION AND CARDIOVASCULAR OTUCOMES IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION UNDERGOING CARDIAC MAGNETIC RESONANCE IMAGING

Author

Bellicini, Mariagiulia, primary, Inciardi, Riccardo Maria, additional, Di Meo, Nunzia, additional, Rondi, Paolo, additional, Cersosimo, Angelica, additional, Lupi, Laura, additional, Pagnesi, Matteo, additional, Gavazzi, Emanuele, additional, Lombardi, Carlo Mario, additional, Targher, Giovanni, additional, Farina, Davide, additional, and Metra, Marco, additional

Published
2022
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47. Value of the HFA‐PEFF andH 2 FPEFscores in patients with heart failure and preserved ejection fraction caused by cardiac amyloidosis

Author

Tomasoni, Daniela, primary, Aimo, Alberto, additional, Merlo, Marco, additional, Nardi, Matilde, additional, Adamo, Marianna, additional, Bellicini, Maria Giulia, additional, Cani, Dario, additional, Franzini, Maria, additional, Khalil, Anas, additional, Pancaldi, Edoardo, additional, Panichella, Giorgia, additional, Porcari, Aldostefano, additional, Rossi, Maddalena, additional, Vergaro, Giuseppe, additional, Lombardi, Carlo Mario, additional, Sinagra, Gianfranco, additional, Rapezzi, Claudio, additional, Emdin, Michele, additional, and Metra, Marco, additional

Published
2022
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49. Impact of Continuous Flow Left Ventricular Assist Device on Heart Transplant Candidates: A Multi-State Survival Analysis

Author

Carrozzini, Massimiliano, primary, Bottio, Tomaso, additional, Caraffa, Raphael, additional, Bejko, Jonida, additional, Bifulco, Olimpia, additional, Guariento, Alvise, additional, Lombardi, Carlo Mario, additional, Metra, Marco, additional, Azzolina, Danila, additional, Gregori, Dario, additional, Fedrigo, Marny, additional, Castellani, Chiara, additional, Tarzia, Vincenzo, additional, Toscano, Giuseppe, additional, Gambino, Antonio, additional, Jorgji, Vjola, additional, Ferrari, Enrico, additional, Angelini, Annalisa, additional, and Gerosa, Gino, additional

Published
2022
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