380 results on '"Lombard, David B."'
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2. Correction: Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemia
3. Pan-cancer Genomic Analysis of AXL Mutations Reveals a Novel, Recurrent, Functionally Activating AXL W451C Alteration Specific to Myxofibrosarcoma
4. Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice
5. Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
6. Melanoma models for the next generation of therapies
7. Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors
8. Epigenetic mechanisms of cadmium-induced nephrotoxicity
9. Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors
10. Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload
11. SIRT5 variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology
12. List of contributors
13. Sirtuins, healthspan, and longevity in mammals
14. Pan-cancer Genomic Analysis of AXLMutations Reveals a Novel, Recurrent, Functionally Activating AXLW451C Alteration Specific to Myxofibrosarcoma
15. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
16. Abstract P3131: SIRTUIN5 Modulates Na + /Ca 2+ Handling Through Oxidative Stress Dependent Mechanism In Mouse Heart
17. Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation
18. PTEN is both an activator and a substrate of chaperone-mediated autophagy
19. Diverse Roles for SIRT6 in Mammalian Healthspan and Longevity
20. An optimized desuccinylase activity assay reveals a difference in desuccinylation activity between proliferative and differentiated cells
21. Nucleolar Localization of the Werner Syndrome Protein in Human Cells
22. Biallelic variants in COQ7 cause distal hereditary motor neuropathy with upper motor neuron signs
23. Familial Clonal Hematopoiesis in a Long Telomere Syndrome
24. The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease
25. Roles for Sirtuins in Cardiovascular Biology
26. List of Contributors
27. Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
28. Nijmegen Breakage Syndrome disease protein and Mre11 at PML Nuclear Bodies and meiotic telomeres
29. Targeting the WRN Locus in the mouse
30. Interaction of the BLM protein with Topo III alpha in Somatic and meiotic cells
31. The RecQ-family helicases
32. Mitochondrial Sirtuins in the Regulation of Mitochondrial Activity and Metabolic Adaptation
33. Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5
34. Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice
35. Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5
36. Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples
37. Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context
38. Author response: Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context
39. SIRT3 as a regulator of hepatic autophagy
40. Acetyl‐ed question in mitochondrial biology?
41. Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein
42. Sirtuins, Healthspan, and Longevity in Mammals
43. List of Contributors
44. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
45. A Role for the NAD-Dependent Deacetylase Sirt1 in the Regulation of Autophagy
46. ACSF3 and Mal(onate)-Adapted Mitochondria
47. SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production
48. SIRT5’s GOT1 up on PDAC
49. Assessment of Cellular Bioenergetics in Mouse Hematopoietic Stem and Primitive Progenitor Cells using the Extracellular Flux Analyzer
50. Abstract P511: Sirtuin 5 Overexpression Protects Against Pressure Overload-Induced Ventricular Dysfunction
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