28 results on '"Lombard, CB"'
Search Results
2. A lifestyle intervention programme for the prevention of Type 2 diabetes mellitus among South Asian women with gestational diabetes mellitus [LIVING study]: protocol for a randomized trial
- Author
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Gupta, Y, Kapoor, D, Josyula, LK, Praveen, D, Naheed, A, Desai, AK, Pathmeswaran, A, de Silva, HA, Lombard, CB, Shamsul Alam, D, Prabhakaran, D, Teede, HJ, Billot, L, Bhatla, N, Joshi, R, Zoungas, S, Jan, S, Patel, A, Tandon, N, Gupta, Y, Kapoor, D, Josyula, LK, Praveen, D, Naheed, A, Desai, AK, Pathmeswaran, A, de Silva, HA, Lombard, CB, Shamsul Alam, D, Prabhakaran, D, Teede, HJ, Billot, L, Bhatla, N, Joshi, R, Zoungas, S, Jan, S, Patel, A, and Tandon, N
- Abstract
Aim: This study aims to determine whether a resource- and culturally appropriate lifestyle intervention programme in South Asian countries, provided to women with gestational diabetes (GDM) after childbirth, will reduce the incidence of worsening of glycaemic status in a manner that is affordable, acceptable and scalable. Methods: Women with GDM (diagnosed by oral glucose tolerance test using the International Association of the Diabetes and Pregnancy Study Groups criteria) will be recruited from 16 hospitals in India, Sri Lanka and Bangladesh. Participants will undergo a repeat oral glucose tolerance test at 6 ± 3 months postpartum and those without Type 2 diabetes, a total sample size of 1414, will be randomly allocated to the intervention or usual care. The intervention will consist of four group sessions, 84 SMS or voice messages and review phone calls over the first year. Participants requiring intensification of the intervention will receive two additional individual sessions over the latter half of the first year. Median follow-up will be 2 years. The primary outcome is the proportion of women with a change in glycaemic category, using the American Diabetes Association criteria: (i) normal glucose tolerance to impaired fasting glucose, or impaired glucose tolerance, or Type 2 diabetes; or (ii) impaired fasting glucose or impaired glucose tolerance to Type 2 diabetes. Process evaluation will explore barriers and facilitators of implementation of the intervention in each local context, while trial-based and modelled economic evaluations will assess cost-effectiveness. Discussion: The study will generate important new evidence about a potential strategy to address the long-term sequelae of GDM, a major and growing problem among women in South Asia. (Clinical Trials Registry of India No: CTRI/2017/06/008744; Sri Lanka Clinical Trials Registry No: SLCTR/2017/001; and ClinicalTrials.gov Identifier No: NCT03305939).
- Published
- 2019
3. Exercise therapy in polycystic ovary syndrome: a systematic review.
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Harrison CL, Lombard CB, Moran LJ, and Teede HJ
- Published
- 2011
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4. A systematic review of interventions aimed at the prevention of weight gain in adults.
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Lombard CB, Deeks AA, Teede HJ, Lombard, Catherine B, Deeks, Amanda A, and Teede, Helena J
- Abstract
Objective: The WHO has recommended that prevention of overweight and obesity should begin early and target adults, including those with an acceptable BMI. The aim of the present paper was to systematically review published interventions with a specific stated aim to prevent weight gain.Design: Five databases were searched to July 2008. The reference lists of review articles and obesity society meetings abstracts were hand searched. Interventions were included if the primary aim was to prevent weight gain and they included a comparison group.Results: Ten publications were included, describing nine separate interventions in adults of various ages and target populations. All interventions incorporated diet and physical activity with behaviour change strategies. Most studies were between 1 and 3 years in duration. Five studies reported a significant difference in weight between intervention and control subjects of between 1.0 and 3.5 kg, due largely to an increase in weight in the control group. However, there was a lack of consistent, clear, psychological models and a failure to identify successful components. More intensive interventions were not always successful, nor were mail-only or clinic-based interventions. In contrast, interventions that included mixed modes of delivery with some personal contact were successful.Conclusions: There were relatively few trials aimed at the prevention of weight gain. Existing trials varied by intensity, delivery methods, target groups and study components, and therefore provide limited opportunities for comparison of effect size. Further large, effective, evidence-based programmes are urgently needed in the general population as well as high-risk groups. [ABSTRACT FROM AUTHOR]- Published
- 2009
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5. Congenital adrenal hyperplasia with associated giant adrenal myelolipoma, testicular adrenal rest tumors and primary pigmented nodular adrenocortical disease: A case report and brief review of the literature.
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Jacobson A, Koberlein E, Thomay A, Lombard CB, Adelanwa A, Lakhani DA, and Smith KT
- Abstract
Congenital adrenal hyperplasia is an autosomal recessive disease most commonly associated with 21-hydroxylase deficiency, an enzyme integral in the biosynthesis of mineralocorticoids and glucocorticoids. We present a case of a 49-year-old male with congenital adrenal hyperplasia and commonly associated findings of adrenal myelolipoma, testicular adrenal rest tumors, as well as primary pigmented nodular adrenocortical disease. Adrenal myelolipoma is a rare, benign disease process associated with exogenous steroid treatment noncompliance in the setting of congenital adrenal hyperplasia. Testicular adrenal rest tumors are benign testicular tumors associated with congenital adrenal hyperplasia. Primary pigmented nodular adrenocortical disease is an ACTH-independent cortisol producing lesion. Our case emphasizes the association of congenital adrenal hyperplasia with adrenal myelolipoma and testicular adrenal rest tumors as well as the importance of familiarity with these associations to guide patient management., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
- Published
- 2021
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6. Testicular cancer metastasis to the soft tissue: A case report and review of the literature.
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Crain MA, Lakhani DA, Balar AB, Martin D, Lombard CB, and Nguyen TP
- Abstract
While germ cell testicular cancer is rare and only accounts for 1% of cancers in males, it is the most common solid malignancy among men between 14 and 44 years of age. Testicular cancer can be surgically excised by orchiectomy and is highly responsive to both chemotherapy and radiation therapy. Therefore, testicular tumors generally have the best cancer prognoses, especially since the majority are localized in the initial stage. However, long-term outcome depends on the potential for germ cell testicular cancer to metastasize, both proximal to the testicles and distally throughout the body. Germ cell testicular cancer metastasis to soft tissue, including the trunk, and extremities, appears to be exceedingly rare, as reflected in the extremely limited number of published cases (total of seven patients reported in literature). Vague symptomatology, delayed medical attention, and inconsistent treatment compliance may contribute to testicular soft tissue metastasis and underreporting of these tumors. Here, we report a case of metastatic non-seminomatous germ cell testicular cancer with a large necrotizing, ulcerative mass in the left Iliopsoas muscle and posterior abdominal wall., (© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.)
- Published
- 2021
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7. A lifestyle intervention programme for the prevention of Type 2 diabetes mellitus among South Asian women with gestational diabetes mellitus [LIVING study]: protocol for a randomized trial.
- Author
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Gupta Y, Kapoor D, Josyula LK, Praveen D, Naheed A, Desai AK, Pathmeswaran A, de Silva HA, Lombard CB, Shamsul Alam D, Prabhakaran D, Teede HJ, Billot L, Bhatla N, Joshi R, Zoungas S, Jan S, Patel A, and Tandon N
- Subjects
- Bangladesh ethnology, Data Collection methods, Diabetes Mellitus, Type 2 ethnology, Diabetes, Gestational ethnology, Ethics, Research, Female, Humans, Multicenter Studies as Topic, Patient Selection, Pregnancy, Randomized Controlled Trials as Topic, Sample Size, Sri Lanka ethnology, Statistics as Topic, Treatment Outcome, Diabetes Mellitus, Type 2 prevention & control, Diabetes, Gestational prevention & control, Healthy Lifestyle
- Abstract
Aim: This study aims to determine whether a resource- and culturally appropriate lifestyle intervention programme in South Asian countries, provided to women with gestational diabetes (GDM) after childbirth, will reduce the incidence of worsening of glycaemic status in a manner that is affordable, acceptable and scalable., Methods: Women with GDM (diagnosed by oral glucose tolerance test using the International Association of the Diabetes and Pregnancy Study Groups criteria) will be recruited from 16 hospitals in India, Sri Lanka and Bangladesh. Participants will undergo a repeat oral glucose tolerance test at 6 ± 3 months postpartum and those without Type 2 diabetes, a total sample size of 1414, will be randomly allocated to the intervention or usual care. The intervention will consist of four group sessions, 84 SMS or voice messages and review phone calls over the first year. Participants requiring intensification of the intervention will receive two additional individual sessions over the latter half of the first year. Median follow-up will be 2 years. The primary outcome is the proportion of women with a change in glycaemic category, using the American Diabetes Association criteria: (i) normal glucose tolerance to impaired fasting glucose, or impaired glucose tolerance, or Type 2 diabetes; or (ii) impaired fasting glucose or impaired glucose tolerance to Type 2 diabetes. Process evaluation will explore barriers and facilitators of implementation of the intervention in each local context, while trial-based and modelled economic evaluations will assess cost-effectiveness., Discussion: The study will generate important new evidence about a potential strategy to address the long-term sequelae of GDM, a major and growing problem among women in South Asia. (Clinical Trials Registry of India No: CTRI/2017/06/008744; Sri Lanka Clinical Trials Registry No: SLCTR/2017/001; and ClinicalTrials.gov Identifier No: NCT03305939)., (© 2018 Diabetes UK.)
- Published
- 2019
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8. Diet Quality in a Weight Gain Prevention Trial of Reproductive Aged Women: A Secondary Analysis of a Cluster Randomized Controlled Trial.
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Martin JC, Moran LJ, Teede HJ, Ranasinha S, Lombard CB, and Harrison CL
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- Adolescent, Adult, Age Factors, Cluster Analysis, Female, Humans, Middle Aged, Young Adult, Diet standards, Obesity prevention & control, Weight Gain
- Abstract
Reproductive-aged women are at high risk for obesity development. Limited research exploring weight gain prevention initiatives and associated modifiable risk factors, including diet quality exists. In a secondary analysis of a 12 month, cluster randomized controlled trial for weight gain prevention in reproductive-aged women, we evaluated change in diet quality, macronutrient and micronutrient intake, predictors of change and associations with weight change at follow-up. Forty-one rural towns in Victoria, Australia were randomized to a healthy lifestyle intervention ( n = 21) or control ( n = 20). Women aged 18⁻50, of any body mass index and without conditions known to affect weight, were recruited. Diet quality was assessed by the Dietary Guideline Index (DGI) and energy, macronutrient, and micronutrient intake as well as anthropometrics (weight; kg) were measured at baseline and 12 months. Results were adjusted for group (intervention/control), town cluster, and baseline values of interest. Of 409 women with matched data at baseline and follow-up, 220 women were included for final analysis after accounting for plausible energy intake. At 12 months, diet quality had improved by 6.2% following the intervention, compared to no change observed in the controls ( p < 0.001). Significant association was found between a change in weight and a change in diet quality score over time β -0.66 (95%CI -1.2, -0.12) p = 0.02. The percentage of energy from protein (%) 0.009 (95%CI 0.002, 0.15) p = 0.01 and glycemic index -1.2 (95%CI -2.1, -0.24) p = 0.02 were also improved following the intervention, compared to the control group. Overall, a low-intensity lifestyle intervention effectively improves diet quality, with associated weight gain preventions, in women of reproductive age.
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- 2018
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9. Optimising the effectiveness of diabetes education in an East Asian population.
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Choi TST, Walker KZ, Lombard CB, and Palermo C
- Abstract
Aim: To explore the collective patterns of learning behaviours and preferences of Chinese people during diabetes education. The study was carried out across three countries and aimed to identify strategies that could be used to tailor diabetes education to Chinese people., Methods: A case study approach was undertaken in three countries (Australia, China and Singapore) using participant observations and qualitative interviews. Purposive sampling was used to select field sites before a snowball technique was employed to identify relevant interviewees. Thematic analysis with pattern matching was used for data analysis., Results: A total of 39 participant observations and 22 interviews were conducted. Chinese people with diabetes were observed seeking advice and recommendations from health professionals. When told clearly what to do, they strived for full compliance. They tended to be submissive during diabetes education and were not likely to raise concerns, negotiate or participate in making medical decisions. They appeared to prefer prescriptive concrete instructions rather than more flexible conceptual education and to believe that behavioural change should be achieved by individual willpower and determination, resulting in an 'all-or-nothing' approach. Regular repeated information sessions were reported to establish rapport and trust., Conclusions: For diabetes education to be culturally modified for Chinese people, there is a need to consider their unique philosophies and behaviours during education to support lifestyle changes. Building trust from the early stages of education was achieved by encouraging rapport through the provision of clear and precise instructions. This should be done before engaging in an open discussion of implementation strategies. Once the trust is built, healthy behaviour change may follow., (© 2017 Dietitians Association of Australia.)
- Published
- 2017
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10. Exploring Diet Quality between Urban and Rural Dwelling Women of Reproductive Age.
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Martin JC, Moran LJ, Teede HJ, Ranasinha S, Lombard CB, and Harrison CL
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- Adult, Australia, Feeding Behavior, Female, Humans, Nutrition Assessment, Socioeconomic Factors, Diet standards, Diet Surveys, Rural Population, Urban Population
- Abstract
Health disparities, including weight gain and obesity exist between urban and rural dwelling women. The primary aim was to compare diet quality in urban and rural women of reproductive age, and secondary analyses of the difference in macronutrient and micronutrient intake in urban and rural women, and the predictors of diet quality. Diet quality was assessed in urban ( n = 149) and rural ( n = 394) women by a modified version of the Dietary Guideline Index (DGI) energy, macronutrient and micronutrient intake from a food frequency questionnaire (FFQ) and predictors of diet quality. Diet quality did not significantly differ between urban and rural women (mean ± standard deviation (SD), 84.8 ± 15.9 vs. 83.9 ± 16.5, p = 0.264). Rural women reported a significantly higher intake of protein, fat, saturated fat, monounsaturated fat, cholesterol and iron and a higher score in the meat and meat alternatives component of the diet quality tool in comparison to urban women. In all women, a higher diet quality was associated with higher annual household income (>$Australian dollar (AUD) 80,000 vs. <$AUD80,000 p = 0.013) and working status (working fulltime/part-time vs. unemployed p = 0.043). Total diet quality did not differ in urban and rural women; however, a higher macronutrient consumption pattern was potentially related to a higher lean meat intake in rural women. Women who are unemployed and on a lower income are an important target group for future dietary interventions aiming to improve diet quality.
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- 2017
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11. Individual, social and environmental factors and their association with weight in rural-dwelling women.
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Harrison CL, Teede HJ, Kozica S, Zoungas S, and Lombard CB
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- Adolescent, Adult, Australia, Body Mass Index, Body Weight, Diet, Reducing, Environment, Female, Health Promotion, Humans, Middle Aged, Obesity epidemiology, Rural Health, Exercise physiology, Health Behavior, Rural Population, Social Environment, Social Support
- Abstract
Objective: Obesity is a major public health concern and women living in rural settings present a high-risk group. With contributing factors poorly explored, we evaluated their association with weight in rural Australian women., Methods: Women aged 18-50 years of any body mass index (BMI) were recruited between October 2012 and April 2013 as part of a larger, randomised controlled trial within 42 rural towns. Measured weight and height as well as self-reported measures of individual health, physical activity, dietary intake, self-management, social support and environmental perception were collected. Statistical analysis included linear regression for continuous variables as well as chi-squared and logistic regression for categorical variables with all results adjusted for clustering., Results: 649 women with a mean baseline age and BMI of 39.6±6.7 years and 28.8±6.9 kg/m
2 respectively, were studied. Overall, 65% were overweight or obese and 60% overall reported recent weight gain. There was a high intention to self-manage weight, with 68% attempting to lose weight recently, compared to 20% of women reporting health professional engagement for weight management. Obese women reported increased weight gain, energy intake, sitting time and prevalence of pre-existing health conditions. There was an inverse relationship between increased weight and scores for self-management, social support and health environment perception., Conclusions: Many women in rural communities reported recent weight gain and were attempting to self-manage their weight with little external support. Implications for public health: Initiatives to prevent weight gain require a multifaceted approach, with self-management strategies and social support in tandem with building a positive local environmental perception., (© 2016 Public Health Association of Australia.)- Published
- 2017
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12. Optimizing Implementation of Obesity Prevention Programs: A Qualitative Investigation Within a Large-Scale Randomized Controlled Trial.
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Kozica SL, Teede HJ, Harrison CL, Klein R, and Lombard CB
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- Adult, Australia, Counseling organization & administration, Female, Humans, Male, Program Evaluation, Surveys and Questionnaires, Health Education organization & administration, Health Promotion methods, Obesity epidemiology, Obesity prevention & control, Rural Health Services organization & administration, Rural Population statistics & numerical data
- Abstract
Purpose: The prevalence of obesity in rural and remote areas is elevated in comparison to urban populations, highlighting the need for interventions targeting obesity prevention in these settings. Implementing evidence-based obesity prevention programs is challenging. This study aimed to investigate factors influencing the implementation of obesity prevention programs, including adoption, program delivery, community uptake, and continuation, specifically within rural settings., Methods: Nested within a large-scale randomized controlled trial, a qualitative exploratory approach was adopted, with purposive sampling techniques utilized, to recruit stakeholders from 41 small rural towns in Australia. In-depth semistructured interviews were conducted with clinical health professionals, health service managers, and local government employees. Open coding was completed independently by 2 investigators and thematic analysis undertaken., Findings: In-depth interviews revealed that obesity prevention programs were valued by the rural workforce. Program implementation is influenced by interrelated factors across: (1) contextual factors and (2) organizational capacity. Key recommendations to manage the challenges of implementing evidence-based programs focused on reducing program delivery costs, aided by the provision of a suite of implementation and evaluation resources. Informing the scale-up of future prevention programs, stakeholders highlighted the need to build local rural capacity through developing supportive university partnerships, generating local program ownership and promoting active feedback to all program partners., Conclusion: We demonstrate that the rural workforce places a high value on obesity prevention programs. Our results inform the future scale-up of obesity prevention programs, providing an improved understanding of strategies to optimize implementation of evidence-based prevention programs., (© 2015 National Rural Health Association.)
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- 2016
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13. Evaluation of a large healthy lifestyle program: informing program implementation and scale-up in the prevention of obesity.
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Kozica SL, Lombard CB, Harrison CL, and Teede HJ
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- Adult, Australia, Female, Humans, Surveys and Questionnaires, Health Behavior, Health Promotion methods, Life Style, Obesity prevention & control, Program Evaluation methods, Rural Population statistics & numerical data
- Abstract
Background: The Healthy Lifestyle Program for women (HeLP-her) is a low-intensity, self-management program which has demonstrated efficacy in preventing excess weight gain in women. However, little is known about the implementation, reach, and sustainability of low-intensity prevention programs in rural settings, where risk for obesity in women is higher than urban settings. We aimed to evaluate a low-intensity healthy lifestyle program delivered to women in a rural setting to inform development of effective community prevention programs., Methods: A mixed method hybrid implementation and evaluation study, guided by the RE-AIM framework (addressing the Reach, Effectiveness, Adoption, Implementation, and Maintenance), was undertaken. Data collection tools included anthropometric measures, program checklists, questionnaires, and semi-structured interviews with participants and local stakeholders. The RE-AIM self-audit tool was applied to assess evaluation rigor., Results: Six hundred and forty-nine women from 41 relatively socio-economic disadvantaged communities in Australia participated: mean age 39.6 years (±SD 6.7) and body mass index of 28.8 kg/m
2 (±SD 6.9). A between-group weight difference of -0.92 kg (95% CI -1.67 to -0.16) showed program effectiveness. Reach was broad across 41 towns with 62% of participants reporting influencing some of the health behaviors of their families. Strong implementation fidelity was achieved with good retention rates at 1 year (76%) and high participant satisfaction (82% of participants willing to recommend this program). Over 300 multi-level community partnerships were established supporting high adoption. Stakeholders reported potential capacity to implement and sustain the prevention program in resource poor rural settings, due to the low-intensity design and minimal resources required., Conclusions: Our comprehensive RE-AIM evaluation demonstrates that an evidence-based obesity prevention program can be successfully implemented in real-world settings. The program achieved broad reach, effectiveness, and satisfaction at the community and stakeholder level, revealing potential for program sustainability. The evaluation addressed implementation knowledge gaps to support future obesity prevention program scale-up., Trial Registration: Australian and New Zealand Clinical Trial Registry ACTRN 12612000115831 [ http://www.anzctr.org.au/ ].- Published
- 2016
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14. Weight satisfaction, management strategies and health beliefs in knee osteoarthritis patients attending an outpatient clinic.
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Ekram AR, Cicuttini FM, Teichtahl AJ, Crammond BR, Lombard CB, Liew SM, Urquhart DM, and Wluka AE
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- Aged, Female, Humans, Life Style, Male, Middle Aged, Osteoarthritis, Knee epidemiology, Osteoarthritis, Knee therapy, Overweight epidemiology, Overweight therapy, Personal Satisfaction, Weight Loss physiology, Body Weight physiology, Disease Management, Health Knowledge, Attitudes, Practice, Osteoarthritis, Knee psychology, Outpatient Clinics, Hospital, Overweight psychology
- Abstract
Background: Although weight control is important in managing knee osteoarthritis (OA), it is difficult to achieve. Understanding beliefs regarding weight management in people with knee OA may improve weight control., Aims: To examine differences in bodyweight satisfaction, weight management strategies and weight-related health-beliefs in obese, overweight and normal weight people with knee OA., Methods: The beliefs and attitudes to weight in 102 people with symptomatic knee OA were ascertained. Participants were classified as being obese, overweight or of normal weight., Results: Although obese and overweight participants were less satisfied with their bodyweight, they were more likely to want to lose weight and to report dieting compared with normal weight participants(P < 0.001 for all) and also more likely to report weight gain in the past 6 months (P < 0.001). While most participants rated food intake to be a main determinant of health, this belief was more common in normal weight participants (P = 0.04). When asked about their own weight gain, obese participants more frequently believed genetic and metabolic factors to be important than normal and overweight participants (P = 0.01). While 51 (53%) believed that increasing activity was more important than dietary change to avoid weight gain, this was more commonly believed by obese and overweight participants (P < 0.05)., Conclusions: Despite desiring and attempting to lose weight, obese people with symptomatic knee OA more commonly reported weight gain. Overweight and obese participants attributed weight gain to non-modifiable factors but believed physical activity is more important than dietary change in weight management. Thus, education regarding the importance of diet as compared with non-modifiable factors and physical activity may improve weight management in obese people with knee OA., (© 2016 Royal Australasian College of Physicians.)
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- 2016
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15. Erratum: Optimizing healthy gestational weight gain in women at high risk of gestational diabetes: A randomized controlled trial.
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Harrison CL, Lombard CB, Strauss BJ, and Teede HJ
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- 2016
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16. Engaging rural women in healthy lifestyle programs: insights from a randomized controlled trial.
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Kozica SL, Harrison CL, Teede HJ, Ng S, Moran LJ, and Lombard CB
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- Adolescent, Adult, Australia epidemiology, Female, Humans, Interviews as Topic, Life Style, Middle Aged, Motivation, Obesity diagnosis, Obesity epidemiology, Obesity physiopathology, Obesity psychology, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Time Factors, Treatment Outcome, Weight Loss, Young Adult, Health Knowledge, Attitudes, Practice, Obesity prevention & control, Patient Acceptance of Health Care, Patient Selection, Research Subjects psychology, Risk Reduction Behavior, Rural Health, Women's Health
- Abstract
Background: The obesity epidemic is well established, particularly in rural settings. Programs promoting healthy lifestyles for rural women are urgently needed; however, participant engagement is challenging. In the context of a large randomized controlled trial targeting the prevention of weight gain in rural women, we explored successful recruitment strategies and aimed to understand participants' barriers, enablers and reasons for program participation., Methods: We recruited women (aged 18-55 years) from the general rural Australian population. A mixed-methods approach was applied to explore factors that influenced program participation, including quantitative questionnaires for all participants (n = 649) and qualitative semi-structured interviews conducted for a subgroup of participants (n = 45). Data were collected at three time points: baseline, 6 and 12 months post program commencement., Results: We recruited 649 rural women through a community communication and partnering strategy, a program marketing campaign and mobilization of social networks. Program participants were diverse across education and income levels and were representative of the wider Australian regional population. Factors that influenced program engagement were divided into personal (perceived program benefits and program accessibility) and social (peer persuasion and support). Identified enablers included convenience of the program location, perceived program utility, such as weight management and optimization of lifestyle choices, as well as attending the program with peer support. Barriers to engagement, which are likely exacerbated in rural communities included lack of anonymity, self-consciousness and segregated social networks in rural settings. Participants reported that eliciting local support and maximizing publicity is fundamental to improving future program engagement., Conclusion: Multiple program promotion strategies including communication, marketing and partnering, as well as mobilization of social networks and peer persuasion, enabled engagement of rural women into a healthy lifestyle program. These recruitment strategies are consistent with successful strategies utilized previously to recruit urban-dwelling women into lifestyle programs. Future engagement efforts in rural settings could be enhanced by hosting multiple sessions within existing socio-cultural networks and assuring participants that they will not need to share their personal health information with others in their community., Trial Registration: Australia & New Zealand Clinical Trial Registry. Trial number ACTRN12612000115831. Date of registration 24 January 2012.
- Published
- 2015
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17. Acceptability of delivery modes for lifestyle advice in a large scale randomised controlled obesity prevention trial.
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Kozica SL, Lombard CB, Ilic D, Ng S, Harrison CL, and Teede HJ
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- Adult, Female, Humans, Middle Aged, Program Evaluation, Research Design, Rural Population, Socioeconomic Factors, Surveys and Questionnaires, Text Messaging, Victoria, Weight Gain, Health Behavior, Health Promotion methods, Life Style, Obesity prevention & control
- Abstract
Background: Preventing obesity is an international health priority and women living in rural communities are at an increased risk of weight gain. Lifestyle programs are needed as part of a comprehensive approach to prevent obesity. Evaluation provides a unique opportunity to investigate and inform improvements in lifestyle program implementation strategies. The Healthy Lifestyle Program for rural women (HeLP-her Rural) is a large scale, cluster randomized control trial, targeting the prevention of weight gain. This program utilises multiple delivery modes for simple lifestyle advice (group sessions, phone coaching, text messages, and an interactive program manual). Here, we describe the acceptability of these various delivery modes., Methods: A mixed-method process evaluation was undertaken measuring program fidelity, recruitment strategies, dose delivered, program acceptability and contextual factors influencing program implementation. Data collection methodologies included qualitative semi-structured interviews for a sub-group of intervention participants [n = 28] via thematic analysis and quantitative methods (program checklists and questionnaires [n = 190]) analysed via chi square and t-tests., Results: We recruited 649 women from 41 rural townships into the HeLP-her Rural program with high levels of program fidelity, dose delivered and acceptability. Participants were from low socioeconomic townships and no differences were detected between socioeconomic characteristics and the number of participants recruited across the towns (p = 0.15). A face-to-face group session was the most commonly reported preferred delivery mode for receiving lifestyle advice, followed by text messages and phone coaching. Multiple sub-themes emerged to support the value of group sessions which included: promoting of a sense of belonging, mutual support and a forum to share ideas. The value of various delivery modes was influenced by participant's various needs and learning styles., Conclusion: This comprehensive evaluation reveals strong implementation fidelity and high levels of dose delivery. We demonstrate reach to women from relatively low income rural townships and highlight the acceptability of low intensity healthy lifestyle programs with mixed face-to-face and remote delivery modes in this population. Group education sessions were the most highly valued component of the intervention, with at least one face-to-face session critical to successful program implementation. However, lifestyle advice via multiple delivery modes is recommended to optimise program acceptability and ultimately effectiveness., Trial Registry: Australia & New Zealand Clinical Trial Registry. Trial number ACTRN12612000115831, date of registration 24/01/2012.
- Published
- 2015
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18. Risk stratification in early pregnancy for women at increased risk of gestational diabetes.
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Harrison CL, Lombard CB, East C, Boyle J, and Teede HJ
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- Adult, Blood Glucose metabolism, Cholesterol blood, Cholesterol, HDL blood, Cohort Studies, Diabetes, Gestational diagnosis, Female, Humans, Logistic Models, Predictive Value of Tests, Randomized Controlled Trials as Topic methods, Retrospective Studies, Risk, Triglycerides blood, Diabetes, Gestational blood, Pregnancy blood
- Abstract
Aim: To evaluate the addition of fasting glucose and lipids to a simple, validated risk prediction tool for gestational diabetes (GDM) applied in early pregnancy., Methods: Women at risk of developing GDM on a validated risk prediction tool were recruited in early pregnancy into a large randomised controlled trial. Outcome measures included fasting biochemical markers (glucose, lipids) at 12-15 weeks gestation and GDM diagnosis (28 weeks gestation). Multivariable logistic regression was used to identify additional predictive biochemical variables for GDM, with corresponding receiver operator characteristic (ROC) curves generated. Unadjusted and adjusted models were derived for both the Australasian Diabetes in Pregnancy (ADIPS) and the International Association for Diabetes in Pregnancy Study Group (IADPSG) GDM diagnostic criteria., Results: 51 (23%) Women were diagnosed with GDM based on ADIPS criteria, with 60 (30%) diagnosed based on IADPSG criteria. In all four regression models, fasting glucose was the strongest predictor for GDM development with an odds ratio range of 4.7-6.3 (ADIPS) and 8.8-10 (IADPSG). ROC curves revealed an area under the curve of 0.79 (95% CI: 0.72-0.86) for ADIPS criteria and 0.83 (95% CI: 0.77-0.90) for IADPSG criteria for adjusted models., Conclusions: In a two-step approach, when applied with a validated risk prediction tool, fasting glucose in early pregnancy was predictive of GDM and incrementally improved risk identification, presenting potential for an early pregnancy, GDM risk screening strategy for streamlining of pregnancy care and opportunity for preventive intervention., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
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19. Limiting postpartum weight retention through early antenatal intervention: the HeLP-her randomised controlled trial.
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Harrison CL, Lombard CB, and Teede HJ
- Subjects
- Adult, Body Mass Index, Diabetes, Gestational, Diet, Female, Humans, Life Style, Motor Activity, Obesity prevention & control, Overweight prevention & control, Pregnancy, Prenatal Care, Risk Factors, Surveys and Questionnaires, Treatment Outcome, Health Behavior, Postpartum Period, Weight Gain
- Abstract
Background: Pregnancy is a recognised high risk period for excessive weight gain, contributing to postpartum weight retention and obesity development long-term. We aimed to reduce postpartum weight retention following a low-intensity, self-management intervention integrated with routine antenatal care during pregnancy., Methods: 228 women at increased risk of gestational diabetes, <15 weeks gestation were randomised to intervention (4 self-management sessions) or control (generic health information). Outcomes, collected at baseline and 6 weeks postpartum, included anthropometrics (weight and height), physical activity (pedometer) and questionnaires (health behaviours)., Results: Mean age (32.3 ± 4.7 and 31.7 ± 4.4 years) and body mass index (30.4 ± 5.6 and 30.3 ± 5.9 kg/m2) were similar between intervention and control groups, respectively at baseline. By 6 weeks postpartum, weight change in the control group was significantly higher than the intervention group with a between group difference of 1.45 ± 5.1 kg (95% CI: -2.86,-0.02; p < 0.05) overall, with a greater difference in weight found in overweight, but not obese women. Intervention group allocation, higher baseline BMI, GDM diagnosis, country of birth and higher age were all independent predictors of lower weight retention at 6 weeks postpartum on multivariable linear regression. Other factors related to weight including physical activity, did not differ between groups., Conclusions: A low intensity intervention, integrated with standard antenatal care is effective in limiting postpartum weight retention. Implementation research is now required for scale-up to optimise antenatal health care., Trial Registration: Australian New Zealand Clinical Trial Registry Number: ACTRN12608000233325. Registered 7/5/2008.
- Published
- 2014
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20. How effective is self-weighing in the setting of a lifestyle intervention to reduce gestational weight gain and postpartum weight retention?
- Author
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Harrison CL, Teede HJ, and Lombard CB
- Subjects
- Adult, Behavior Therapy, Female, Humans, Obesity therapy, Postnatal Care, Pregnancy, Prenatal Care, Weight Reduction Programs, Life Style, Self Care, Weight Gain, Weight Loss
- Abstract
Self-weighing is important for weight management in general populations; however its role in optimising gestational weight gain is less clear. Our randomised trial in early pregnancy found regular self-weighing when combined with a self-management intervention, optimised weight gain at 28 weeks gestation (5.66 ± 2.6 kg vs 7.03 ± 3.56 kg, P = 0.02) and reduced postpartum weight retention (-0.57 ± 3.94 kg vs 1.48 ± 5.49 kg, P < 0.05) compared with control participants. Results highlight the importance of self-monitoring strategies during pregnancy., (© 2014 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.)
- Published
- 2014
- Full Text
- View/download PDF
21. Effectiveness and implementation of an obesity prevention intervention: the HeLP-her Rural cluster randomised controlled trial.
- Author
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Lombard CB, Harrison CL, Kozica SL, Zoungas S, Keating C, and Teede HJ
- Subjects
- Adolescent, Adult, Female, Humans, Middle Aged, Obesity prevention & control, Program Development, Research Design, Rural Population, Victoria epidemiology, Women's Health, Health Behavior, Health Promotion methods, Obesity epidemiology
- Abstract
Background: To impact on the obesity epidemic, interventions that prevent weight gain across populations are urgently needed. However, even the most efficacious interventions will have little impact on obesity prevention unless they are successfully implemented in diverse populations and settings. Implementation research takes isolated efficacy studies into practice and policy and is particularly important in obesity prevention where there is an urgent need to accelerate the evidence to practice cycle. Despite the recognised need, few obesity prevention interventions have been implemented in real life settings and to our knowledge rarely target rural communities., Methods: Here we describe the rationale, design and implementation of a Healthy Lifestyle Program for women living in small rural communities (HeLP-her Rural). The primary goal of HeLP-her Rural is to prevent weight gain using a low intensity, self-management intervention. Six hundred women from 42 small rural communities in Australia will be randomised as clusters (n-21 control towns and n = 21 intervention towns). A pragmatic randomised controlled trial methodology will test efficacy and a comprehensive mixed methods community evaluation and cost analysis will inform effectiveness and implementation of this novel prevention program., Discussion: Implementing population interventions to prevent obesity is complex, costly and challenging. To address these barriers, evidence based interventions need to move beyond isolated efficacy trials and report outcomes related to effectiveness and implementation. Large pragmatic trials provide an opportunity to inform both effectiveness and implementation leading to potential for greater impact at the population level. Pragmatic trials should incorporate both effectiveness and implementation outcomes and a multidimensional methodology to inform scale-up to population level. The learnings from this trial will impact on the design and implementation of population obesity prevention strategies nationally and internationally., Trial Registration: ANZ clinical trial registry ACTRN12612000115831. Date of registration 24/01/2012.
- Published
- 2014
- Full Text
- View/download PDF
22. Optimizing healthy gestational weight gain in women at high risk of gestational diabetes: a randomized controlled trial.
- Author
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Harrison CL, Lombard CB, Strauss BJ, and Teede HJ
- Subjects
- Adult, Diabetes, Gestational epidemiology, Female, Humans, Motor Activity, Obesity complications, Obesity therapy, Pregnancy, Prenatal Care, Risk Factors, Body Mass Index, Diabetes, Gestational prevention & control, Life Style, Walking, Weight Gain
- Abstract
Objective: Optimizing gestational weight gain (GWG) in early pregnancy is of clinical and public health importance, especially in higher risk pregnancies., Design and Methods: In a robustly designed, randomized controlled trial, 228 pregnant women at risk of developing gestational diabetes mellitus (GDM) were allocated to either control (written health information only) or intervention (four-session lifestyle program). All women received standard maternal care. Measures were completed at 12-15 and 26-28 weeks gestation. Measures included anthropometrics (weight and height), physical activity (pedometer and International Physical Activity Questionnaire), questionnaires (risk perception), and GDM screening., Results: The mean (SD) age [31.7 (4.5) and 32.4 (4.7) years] and body mass index [BMI; 30.3 (5.9) and 30.4 (5.6) kg/m(2) ] were similar between control and intervention groups, respectively. By 28 weeks, GWG was significantly different between control and intervention groups [6.9 (3.3) vs. 6.0 (2.8) kg, P < 0.05]. When stratified according to baseline BMI, overweight women in the control group gained significantly more weight compared to overweight women in the intervention group [7.8 (3.4) vs. 6.0 (2.2) kg, P < 0.05], yet in obese women, GWG was similar in both groups. Physical activity levels declined by 28 weeks gestation overall (P < 0.01); however, the intervention group retained a 20% higher step count compared to controls [5,203 (3,368) vs. 4,140 (2,420) steps/day, P < 0.05]. Overall, GDM prevalence was 22.8% [Corrected], with a trend toward less cases in the intervention group (P = 0.1)., Conclusions: Results indicate that a low-intensity lifestyle intervention, integrated with antenatal care, optimizes healthy GWG and attenuates physical activity decline in early pregnancy. Efficacy in limiting weight gain was greatest in overweight women and in high-risk ethnically diverse women., (Copyright © 2013 The Obesity Society.)
- Published
- 2013
- Full Text
- View/download PDF
23. Tackling obesity in knee osteoarthritis.
- Author
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Wluka AE, Lombard CB, and Cicuttini FM
- Subjects
- Aged, Aged, 80 and over, Bariatric Surgery methods, Body Composition, Body Mass Index, Comorbidity, Diet, Fat-Restricted, Exercise physiology, Female, Humans, Male, Middle Aged, Obesity therapy, Overweight epidemiology, Overweight prevention & control, Overweight therapy, Prognosis, Randomized Controlled Trials as Topic, Risk Assessment, Severity of Illness Index, Stress, Mechanical, Weight Loss, Weight-Bearing, Life Style, Obesity epidemiology, Obesity prevention & control, Osteoarthritis, Knee epidemiology, Osteoarthritis, Knee physiopathology
- Abstract
Obesity and knee osteoarthritis (OA), two of the most common chronic diseases, are often comorbid. Obesity increases the risk of knee OA by a variety of mechanisms, such as increased joint loading and changes in body composition, with detrimental effects related to metainflammation and behavioural factors, including diminished physical activity and subsequent loss of protective muscle strength. These complex interactions present a challenge to the managing physician. The risk of knee OA related to weight gain and obesity begins from an early age. Weight loss reduces the risk of incident knee OA, and, in established disease, reduces symptoms, improves function and is likely to reduce disease progression. We review strategies to facilitate weight loss, with particular reference to their application in people with knee OA. Although knee OA presents intrinsic barriers to weight management, weight loss is possible at all stages of disease. Exercise or muscle strengthening are desirable for general health and to improve function, but are not essential to achieve weight loss and a successful symptomatic result. The degree of weight loss required to achieve benefit might be greater with increasing disease severity. Finally, we outline the need for a societal approach to tackle obesity-related OA.
- Published
- 2013
- Full Text
- View/download PDF
24. Understanding health behaviours in a cohort of pregnant women at risk of gestational diabetes mellitus: an observational study.
- Author
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Harrison CL, Lombard CB, and Teede HJ
- Subjects
- Adolescent, Adult, Female, Humans, Pregnancy, Pregnancy Trimester, First, Pregnancy Trimester, Second, Risk Factors, Young Adult, Diabetes, Gestational epidemiology, Exercise, Health Behavior, Health Knowledge, Attitudes, Practice, Weight Gain
- Abstract
Objective: To assess health behaviours, physical activity levels, weight gain and development of gestational diabetes mellitus (GDM) in high-risk women., Design: An observational sub-study of a larger randomised controlled trial., Setting: A large tertiary hospital in Australia., Population: Ninety-seven women (mean age 31.7 ± 4.5 years; body mass index 30.3 ± 5.9 kg/m(2) ) at risk of developing GDM., Methods: Women were identified as at risk of GDM based on a validated screening tool. Baseline measures were completed at 12-15 weeks of gestation and repeated at 26-28 weeks of gestation., Main Outcome Measures: Anthropometric (weight and height) and physical activity assessment (Yamax pedometer and International physical activity questionnaire), questionnaires (self-efficacy) and GDM screening., Results: By 28 weeks of gestation, there was a high GDM prevalence of 26% using the recent International Association of Diabetes and Pregnancy Study Group criteria. Weight gain in overweight (body mass index 25-29.9 kg/m(2)) and obese (body mass index >30.0 kg/m(2)) women exceeded minimum total weight gain recommendations set by the Institute of Medicine (P < 0.01). Physical activity levels were low and declined during pregnancy (5437 ± 2951 steps/day to 4096 ± 2438 steps/day, respectively, P < 0.001). Despite reduced activity levels, increased weight gain and high GDM incidence many women did not accurately perceive GDM risk and were confident in their ability to control weight. A significant association with physical activity, weight and GDM outcome was not observed., Conclusions: Overweight and obese pregnant women at risk for developing GDM demonstrate excessive weight gain and a reduced level of physical activity observed from early pregnancy to 28 weeks of gestation. Results highlight the need for targeted intervention in women at risk for developing GDM., (© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.)
- Published
- 2012
- Full Text
- View/download PDF
25. Measuring physical activity during pregnancy.
- Author
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Harrison CL, Thompson RG, Teede HJ, and Lombard CB
- Subjects
- Female, Humans, Monitoring, Ambulatory instrumentation, Motor Activity, Reproducibility of Results, Surveys and Questionnaires, Actigraphy methods, Energy Metabolism, Exercise, Monitoring, Ambulatory methods, Pregnancy, Self Report, Walking
- Abstract
Background: Currently, little is known about physical activity patterns in pregnancy with prior estimates predominantly based on subjective assessment measures that are prone to error. Given the increasing obesity rates and the importance of physical activity in pregnancy, we evaluated the relationship and agreement between subjective and objective physical activity assessment tools to inform researchers and clinicians on optimal assessment of physical activity in pregnancy., Methods: 48 pregnant women between 26-28 weeks gestation were recruited. The Yamax pedometer and Actigraph accelerometer were worn for 5-7 days under free living conditions and thereafter the International Physical Activity Questionnaire (IPAQ) was completed. IPAQ and pedometer estimates of activity were compared to the more robust and accurate accelerometer data., Results: Of 48 women recruited, 30 women completed the study (mean age: 33.6 ± 4.7 years; mean BMI: 31.2 ± 5.1 kg/m(2)) and 18 were excluded (failure to wear [n = 8] and incomplete data [n = 10]). The accelerometer and pedometer correlated significantly on estimation of daily steps (ρ = 0.69, p < 0.01) and had good absolute agreement with low systematic error (mean difference: 505 ± 1498 steps/day). Accelerometer and IPAQ estimates of total, light and moderate Metabolic Equivalent minutes/day (MET min(-1) day(-1)) were not significantly correlated and there was poor absolute agreement. Relative to the accelerometer, the IPAQ under predicted daily total METs (105.76 ± 259.13 min(-1) day(-1)) and light METs (255.55 ± 128.41 min(-1) day(-1)) and over predicted moderate METs (-112.25 ± 166.41 min(-1) day(-1))., Conclusion: Compared with the accelerometer, the pedometer appears to provide a reliable estimate of physical activity in pregnancy, whereas the subjective IPAQ measure performed less accurately in this setting. Future research measuring activity in pregnancy should optimally encompass objective measures of physical activity., Trial Registration: Australian New Zealand Clinical Trial Registry Number: ACTRN12608000233325. Registered 7/5/2008.
- Published
- 2011
- Full Text
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26. Polycystic ovary syndrome and weight management.
- Author
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Moran LJ, Lombard CB, Lim S, Noakes M, and Teede HJ
- Subjects
- Adult, Behavior Therapy methods, Body Mass Index, Comorbidity, Exercise, Female, Health Behavior, Humans, Middle Aged, Overweight epidemiology, Overweight prevention & control, Polycystic Ovary Syndrome epidemiology, Polycystic Ovary Syndrome prevention & control, Stress, Psychological epidemiology, Stress, Psychological prevention & control, Women's Health, Attitude to Health, Health Education methods, Life Style, Overweight therapy, Polycystic Ovary Syndrome therapy, Weight Loss
- Abstract
Polycystic ovary syndrome (PCOS) is a common condition in women of reproductive age, and has reproductive, metabolic and psychological implications. Weight gain and obesity worsen the features of PCOS, while weight loss improves the features of PCOS. While there are potential barriers to successful weight management in young women who do not suffer from PCOS, women with PCOS may experience additional barriers. Weight management strategies in younger women with or without PCOS should encompass both the prevention of excess weight gain and achieving and maintaining a reduced weight through multidisciplinary lifestyle management, comprising dietary, exercise and behavioral therapy, as well as attention to psychosocial stress and practical and physiological barriers to weight management. Further research is warranted in the examination of specific barriers to weight management in women with PCOS, as well as in the determination of optimal components of lifestyle weight management interventions in young women in order to facilitate long-term compliance.
- Published
- 2010
- Full Text
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27. Weight, physical activity and dietary behavior change in young mothers: short term results of the HeLP-her cluster randomized controlled trial.
- Author
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Lombard CB, Deeks AA, Ball K, Jolley D, and Teede HJ
- Subjects
- Adult, Australia, Cluster Analysis, Dietary Fats administration & dosage, Exercise psychology, Female, Fruit, Health Behavior, Health Education, Humans, Life Style, Mothers education, Obesity psychology, Primary Prevention methods, Social Support, Vegetables, Weight Gain, Weight Loss, Women's Health, Diet, Exercise physiology, Mothers psychology, Obesity prevention & control, Self Efficacy
- Abstract
Background: Preventing weight gain rather than treating established obesity is an important economic and public health response to the rapidly increasing rates of obesity worldwide. Treatment of established obesity is complex and costly requiring multiple resources. Preventing weight gain potentially requires fewer resources to reach broad population groups, yet there is little evidence for successful interventions to prevent weight gain in the community. Women with children are an important target group because of high rates of weight gain and the potential to influence the health behaviors in family members., Methods: The aim of this cluster randomized controlled trial was to evaluate the short term effect of a community-based self-management intervention to prevent weight gain. Two hundred and fifty mothers of young children (mean age 40 years +/- 4.5, BMI 27.9 kg/m2 +/- 5.6) were recruited from the community in Melbourne, Australia. The intervention group (n = 127) attended four interactive group sessions over 4 months, held in 12 local primary schools in 2006, and was compared to a group (n = 123) receiving a single, non-interactive, health education session. Data collection included self-reported weight (both groups), measured weight (intervention only), self-efficacy, dietary intake and physical activity., Results: Mean measured weight decreased significantly in the intervention group (-0.78 kg 95% CI; -1.22 to -0.34, p < 0.001). Comparing groups using self-reported weight, both the intervention and comparison groups decreased weight, -0.75 kg (95% CI; -1.57 to 0.07, p = 0.07) and -0.72 kg (95% CI; -1.59 to 0.14 p = 0.10) respectively with no significant difference between groups (-0.03 kg, 95% CI; -1.32 to 1.26, p = 0.95). More women lost or maintained weight in the intervention group. The intervention group tended to have the greatest effect in those who were overweight at baseline and in those who weighed themselves regularly. Intervention women who rarely self-weighed gained weight (+0.07 kg) and regular self-weighers lost weight (-1.66 kg) a difference of -1.73 kg (95% CI; -3.35 to -0.11 p = 0.04). The intervention reported increased physical activity although the difference between groups did not reach significance. Both groups reported replacing high fat foods with low fat alternatives and self-efficacy deteriorated in the comparison group only., Conclusion: Both a single health education session and interactive behavioral intervention will result in a similar weight loss in the short term, although more participants in the interactive intervention lost or maintained weight. There were small non-significant changes to physical activity and changes to fat intake specifically replacing high fat foods with low fat alternatives such as fruit and vegetables. Self-monitoring appears to enhance weight loss when part of an intervention., Trial Registration: ACTRN12608000110381.
- Published
- 2009
- Full Text
- View/download PDF
28. What is the role of food in preventing depression and improving mood, performance and cognitive function?
- Author
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Lombard CB
- Subjects
- Affect, Cognition drug effects, Cognition physiology, Female, Humans, Pyridoxine pharmacology, Depression prevention & control, Diet, Nutritional Physiological Phenomena, Women's Health
- Abstract
Slow weight reduction in overweight women can help to elevate mood. Omega 3 polyunsaturated fatty acids may play a role in mental wellbeing. Eating breakfast regularly leads to improved mood, better memory, more energy and feelings of calmness. Eating regular meals and nutritious afternoon snacks may improve cognitive performance.
- Published
- 2000
- Full Text
- View/download PDF
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