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Background Objectives Methods Results Conclusions Studies on wet work and hand eczema (HE) frequently rely solely on self‐reports regarding wet work.To assess the association between wet work and moderate‐to‐very‐severe HE, within the Dutch general population, by using a (sex‐specific) job exposure matrix (JEM).Within the Lifelines Cohort Study, participants with self‐reported moderate‐to‐very‐severe HE at worst in the past year were linked to data from the Danish (sex‐specific) wet work JEM, a tool that links occupations with wet work indices (including duration and probability of glove use, wet hands and total wet work for at least 2 and 4 h/working day).In total, 56 978 (41.9%) participants were included. The multivariate binary logistic regression analyses showed significant associations between all facets of wet work and moderate‐to‐very‐severe HE. When using the sex‐specific JEM, significant associations were found in females, but not in males.This study is the first to use a wet work‐specific JEM in a general population sample, and found positive associations between wet work and HE. The sex‐specific findings should be interpreted with caution, due to limitations inherent in using a JEM, and should be further explored with observational studies, with a focus on duration, frequency, and exposure type. [ABSTRACT FROM AUTHOR]

Background: Twin studies revealed that genetic effects play a role in hand eczema (HE), but the responsible genetic factors are unknown. Objectives: To identify and characterise genetic loci associated with HE and to provide insight into the genetic overlap between HE and atopic dermatitis (AD). Methods: We used questionnaire‐derived and genotype data from the European population‐based Lifelines cohort and biobank. We performed a discovery genome‐wide association study (GWAS) of HE (2879 cases and 16 249 controls) and of AD (1706 cases and 17 190 controls). We replicated our findings in an independent Lifelines sample for HE (1188 cases and 6431 controls) and AD (757 cases and 6747 controls). We conducted several post‐GWAS analyses and performed genetic correlation analyses between our HE results and independent AD data. Results: The two‐step GWAS of HE, regardless of adjusting for AD, identified one independent locus 20q13.33, likely driven by a number of causal single‐nucleotide polymorphisms. For the AD GWAS, we replicated a known stop‐gained rs61816761 at locus 1q21.3 (FLG, FLGAS1). We found a strong genetic correlation (p < 0.01) between HE and AD (rg = 0.65), regardless of adjusting for AD (rg = 0.63). Conclusions: Locus 20q13.33 is associated with HE, and there is a large genetic overlap between HE and AD. [ABSTRACT FROM AUTHOR]

Hintergrund: Das chronische Handekzem (CHE) ist eine sehr häufige Hauterkrankung in der europäischen Bevölkerung. Es verursacht Juckreiz und Schmerzen und beeinträchtigt in schwereren Fällen die Funktion der Hände bei der Arbeit und im Privatleben erheblich. Ziele: Perspektiven von Menschen zu erforschen, die mit CHE leben, und deren Probleme, Wünsche und Ziele zu verstehen. Methoden: Wir folgten einem qualitativen Ansatz und führten themengeführte Interviews in fünf europäischen Ländern durch. Wir verwendeten eine Template-Analyse, um wiederkehrende Themen bei Patienten mit CHE zu identifizieren. Ergebnisse: Wir befragten 60 Patienten in sieben ambulanten dermatologischen und arbeitsmedizinischen Kliniken in Kroatien, Dänemark, Deutschland, den Niederlanden und Spanien. Es wurden fünf Hauptthemen identifiziert: (1) Wissen über die Krankheit und ihren Verlauf, (2) präventives Verhalten, (3) Therapie des Handekzems, (4) Auswirkungen auf den Alltag und (5) Einstellungen gegenüber dem CHE und der Gesundheitsversorgung. Die Teilnehmer fühlten sich nicht gut über CHE informiert, insbesondere über die Ursachen, Auslöser und Behandlungsmöglichkeiten. Vorbeugende Maßnahmen wurden als mehr oder weniger wirksam, aber auch als umständlich empfunden. Die Erfahrungen mit der Therapie waren vielfältig. Die Behandlungszufriedenheit hing von den erreichten Ergebnissen und der wahrgenommenen Unterstützung durch die Behandlungsteams ab. Die Teilnehmer fanden es wichtig, ernst genommen zu werden, praktische Ratschläge zu erhalten, zusätzliche Behandlungen oder Untersuchungen auszuprobieren, neue Hoffnung zu schöpfen und berufliche Perspektiven zu haben. Sie wünschten sich, dass andere die körperliche und emotionale Belastung durch das CHE besser verstehen könnten. Patientenunterstützungsgruppen wurden nicht erwähnt. Die Teilnehmer fanden es wichtig, zu lernen, mit dem Ekzem umzugehen, und das Leben mit CHE zu akzeptieren. Schlussfolgerungen: Aufgrund der lästigen Symptome, der hohen Sichtbarkeit und der Beeinträchtigung der Hände bei der Arbeit und im Privatleben hat das CHE eine hohe emotionale und soziale Wirkung. Manche Menschen benötigen möglicherweise Unterstützung, um den Umgang mit dem CHE und dessen Prävention zu erlernen. Patienten wünschen sich Informationen über Ursachen und Auslöser. Sie schätzen Ärzte, die ihnen zuhören und immer wieder nach Lösungen suchen. © 2023 Die Autoren. Journal of the European Academy of Dermatology and Venereology, veröffentlicht von John Wiley & Sons Ltd im Auftrag der European Academy of Dermatology and Venereology. [ABSTRACT FROM AUTHOR]

There is a lack of knowledge concerning loneliness and psychiatric disorders other than anxiety and depression in patients with atopic dermatitis. This cross-sectional study was conducted within the Lifelines Cohort Study, in the Netherlands, by sending an atopic dermatitis questionnaire to adult participants (n=135,950) in 2020. Psychiatric disorders were measured with a self-reported question and validated instrument (Mini International Neuropsychiatric Interview; M.I.N.I.), and loneliness was assessed with the validated 6-item De Jong Gierveld Loneliness Scale. In total, 56,896 subjects (mean age 55.8 years, 39.7% males) were included. Atopic dermatitis showed positive associations with self-reported chronic fatigue syndrome, burnout, depression, social phobia, panic disorder, attention deficit hyperactivity disorder, and eating disorder in the participants’ lifetimes. Based on the M.I.N.I., atopic dermatitis was positively associated with panic disorder and at least 1 anxiety disorder. In addition, subjects with atopic dermatitis were more likely to experience loneliness compared with those without atopic dermatitis. These associations were observed only in the moderate-to-severe, but not mild, atopic dermatitis group. This study raises awareness that a significant proportion of adults with atopic dermatitis feel lonely and are affected by several psychiatric disorders, especially those severely affected by atopic dermatitis. Further studies are required to evaluate if interdisciplinary care, such as the collaboration between dermatologists and psychiatrists, could optimize medical care for this vulnerable patient group. [ABSTRACT FROM AUTHOR]

Background: Several risk factors, among other lifestyle factors, have been suggested for hand eczema (HE). Objectives: To investigate a possible association between HE and lifestyle factors, including smoking, alcohol consumption, stress, body mass index (BMI), waist circumference, physical activity, diet, and amount of sleep in the Dutch general population. Methods: Data from the large population‐based LifeLines Cohort Study was used. Individuals with HE in the past year were identified by a cross‐sectional questionnaire in 2020. At baseline, information on lifestyle factors was collected. Results: In total 57 046 individuals were included in the present analysis. Smoking ≥8 cigarettes/day, and smoking ≥15 pack years showed a positive association with HE in the past year. In addition, chronic stress, a BMI >30 kg/m2, and a waist circumference of >90 cm were positively associated with HE in the past year. Conclusions: The current study indicates that lifestyle factors are associated with HE. Advice regarding lifestyle factors might contribute to enhance overall health, of which HE might possibly benefit in conjunction. Further studies should also focus on the association between lifestyle factors and the severity and prognosis of HE rather than on occurrence alone. [ABSTRACT FROM AUTHOR]

Keywords: dupilumab; hand dermatitis; hand eczema; hyperkeratotic hand eczema; treatment EN dupilumab hand dermatitis hand eczema hyperkeratotic hand eczema treatment 124 127 4 01/28/21 20210201 NES 210201 Dupilumab, a monoclonal antibody inhibiting interleukin (IL)-4 and IL-13 signaling, is currently approved for the treatment of atopic dermatitis (AD). Effective treatment of hand eczema with dupilumab has been reported previously in case series, two small retrospective cohorts, and one prospective observational study including atopic, irritant and vesicular hand eczema subgroups.1-4 However, the effect of dupilumab on isolated hyperkeratotic hand eczema (HHE) has not yet been described. Hand eczema guidelines based on the Danish guidelines for the diagnosis and treatment of hand eczema. [Extracted from the article]