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1. Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

Author

Dalvie, Neil C., Rodriguez-Aponte, Sergio A., Hartwell, Brittany L., Tostanoski, Lisa H., Biedermann, Andrew M., Crowell, Laura E., Kaur, Kawaljit, Kumru, Ozan S., Carter, Lauren, Yu, Jingyou, Chang, Aiquan, McMahan, Katherine, Courant, Thomas, Lebas, Celia, Lemnios, Ashley A., Rodrigues, Kristen A., Silva, Murillo, Johnston, Ryan S., Naranjo, Christopher A., Tracey, Mary Kate, Brady, Joseph R., Whittaker, Charles A., Yun, Dongsoo, Brunette, Natalie, Wang, Jing Yang, Walkey, Carl, Fiala, Brooke, Kar, Swagata, Porto, Maciel, Lok, Megan, Andersen, Hanne, Lewis, Mark G., Love, Kerry R., Camp, Danielle L., Silverman, Judith Maxwell, Kleanthous, Harry, Joshi, Sangeeta B., Volkin, David B., Dubois, Patrice M., Collin, Nicolas, King, Neil P., Barouch, Dan H., Irvine, Darrell J., and Love, J. Christopher

Published
2021

2. Passive transfer of Ad26.COV2.S-elicited IgG from humans attenuates SARS-CoV-2 disease in hamsters

Author

Tostanoski, Lisa H., Chandrashekar, Abishek, Patel, Shivani, Yu, Jingyou, Jacob-Dolan, Catherine, Chang, Aiquan, Powers, Olivia C., Sellers, Daniel, Gardner, Sarah, Barrett, Julia, Sanborn, Owen, Stephenson, Kathryn E., Ansel, Jessica L., Jaegle, Kate, Seaman, Michael S., Porto, Maciel, Lok, Megan, Spence, Brittany, Cayer, Kathleen, Nase, Danielle, Holman, Shaikim, Bradette, Heath, Kar, Swagata, Andersen, Hanne, Lewis, Mark G., Cox, Freek, Tolboom, Jeroen T. B. M., de Groot, Anne Marit, Heerwegh, Dirk, Le Gars, Mathieu, Sadoff, Jerald, Wegmann, Frank, Zahn, Roland C., Schuitemaker, Hanneke, and Barouch, Dan H.

Published
2022
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3. Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19

Author

Brumeanu, Teodor-D., primary, Vir, Pooja, additional, Karim, Ahmad Faisal, additional, Kar, Swagata, additional, Benetiene, Dalia, additional, Lok, Megan, additional, Greenhouse, Jack, additional, Putmon-Taylor, Tammy, additional, Kitajewski, Christopher, additional, Chung, Kevin K., additional, Pratt, Kathleen P., additional, and Casares, Sofia A., additional

Published
2022
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4. Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

Author

Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Department of Biological Engineering, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Dalvie, Neil C., Rodriguez-Aponte, Sergio A., Hartwell, Brittany L., Tostanoski, Lisa H., Biedermann, Andrew M., Crowell, Laura E, Kaur, Kawaljit, Kumru, Ozan S., Carter, Lauren, Yu, Jingyou, Chang, Aiquan, McMahan, Katherine, Courant, Thomas, Lebas, Celia, Lemnios, Ashley A., Rodrigues, Kristen A., Silva, Murillo, Johnston, Ryan S., Naranjo, Christopher, Tracey, Mary Kate, Brady, Joseph R., Whittaker, Charles A., Yun, Dongsoo, Brunette, Natalie, Wang, Jing Yang, Walkey, Carl, Fiala, Brooke, Kar, Swagata, Porto, Maciel, Lok, Megan, Andersen, Hanne, Lewis, Mark G., Love, Kerry R., Camp, Danielle L., Silverman, Judith Maxwell, Kleanthous, Harry, Joshi, Sangeeta B., Volkin, David B., Dubois, Patrice M., Collin, Nicolas, King, Neil P., Barouch, Dan H., Irvine, Darrell J, Love, Christopher J., Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology. Department of Biological Engineering, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Dalvie, Neil C., Rodriguez-Aponte, Sergio A., Hartwell, Brittany L., Tostanoski, Lisa H., Biedermann, Andrew M., Crowell, Laura E, Kaur, Kawaljit, Kumru, Ozan S., Carter, Lauren, Yu, Jingyou, Chang, Aiquan, McMahan, Katherine, Courant, Thomas, Lebas, Celia, Lemnios, Ashley A., Rodrigues, Kristen A., Silva, Murillo, Johnston, Ryan S., Naranjo, Christopher, Tracey, Mary Kate, Brady, Joseph R., Whittaker, Charles A., Yun, Dongsoo, Brunette, Natalie, Wang, Jing Yang, Walkey, Carl, Fiala, Brooke, Kar, Swagata, Porto, Maciel, Lok, Megan, Andersen, Hanne, Lewis, Mark G., Love, Kerry R., Camp, Danielle L., Silverman, Judith Maxwell, Kleanthous, Harry, Joshi, Sangeeta B., Volkin, David B., Dubois, Patrice M., Collin, Nicolas, King, Neil P., Barouch, Dan H., Irvine, Darrell J, and Love, Christopher J.

Abstract

Global containment of COVID-19 still requires accessible and affordable vaccines for low- and middle-income countries (LMICs). Recently approved vaccines provide needed interventions, albeit at prices that may limit their global access. Subunit vaccines based on recombinant proteins are suited for large-volume microbial manufacturing to yield billions of doses annually, minimizing their manufacturing cost. These types of vaccines are well-established, proven interventions with multiple safe and efficacious commercial examples. Many vaccine candidates of this type for SARS-CoV-2 rely on sequences containing the receptor-binding domain (RBD), which mediates viral entry to cells via ACE2. Here we report an engineered sequence variant of RBD that exhibits high-yield manufacturability, high-affinity binding to ACE2, and enhanced immunogenicity after a single dose in mice compared to the Wuhan-Hu-1 variant used in current vaccines. Antibodies raised against the engineered protein exhibited heterotypic binding to the RBD from two recently reported SARS-CoV-2 variants of concern (501Y.V1/V2). Presentation of the engineered RBD on a designed virus-like particle (VLP) also reduced weight loss in hamsters upon viral challenge.

Published
2021

5. Design, immunogenicity and efficacy of a Pan-SARS-CoV-2 synthetic DNA vaccine

Author

Reed, Charles C., primary, Schultheis, Katherine, additional, Andrade, Viviane M., additional, Kalia, Richa, additional, Tur, Jared, additional, Schouest, Blake, additional, Elwood, Dustin, additional, Walters, Jewell N., additional, Maricic, Igor, additional, Doan, Arthur, additional, Vazquez, Miguel, additional, Eblimit, Zeena, additional, Pezzoli, Patrick, additional, Amante, Dinah, additional, Porto, Maciel, additional, Narvaez, Brandon, additional, Lok, Megan, additional, Spence, Brittany, additional, Bradette, Heath, additional, Horn, Heather, additional, Yang, Maria, additional, Fader, Joseph, additional, Ferrer, Roi, additional, Weiner, David B., additional, Kar, Swagata, additional, Kim, J. Joseph, additional, Humeau, Laurent M., additional, Ramos, Stephanie J., additional, Smith, Trevor R.F., additional, and Broderick, Kate E., additional

Published
2021
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6. A Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO.IL-2Rγc KO. NOD) for COVID-19

Author

Brumeanu, Teodor-Doru, primary, Vir, Pooja, additional, Karim, Ahmad Faisal, additional, Kar, Swagata, additional, Benetiene, Dalia, additional, Lok, Megan, additional, Greenhouse, Jack, additional, Putmon-Taylor, Tammy, additional, Kitajewski, Christopher, additional, Chung, Kevin K., additional, Pratt, Kathleen P., additional, and Casares, Sofia A., additional

Published
2021
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7. Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters

Author

Dalvie, Neil C., primary, Rodriguez-Aponte, Sergio A., additional, Hartwell, Brittany L., additional, Tostanoski, Lisa H., additional, Biedermann, Andrew M., additional, Crowell, Laura E., additional, Kaur, Kawaljit, additional, Kumru, Ozan, additional, Carter, Lauren, additional, Yu, Jingyou, additional, Chang, Aiquan, additional, McMahan, Katherine, additional, Courant, Thomas, additional, Lebas, Celia, additional, Lemnios, Ashley A., additional, Rodrigues, Kristen A., additional, Silva, Murillo, additional, Johnston, Ryan S., additional, Naranjo, Christopher A., additional, Tracey, Mary Kate, additional, Brady, Joseph R., additional, Whittaker, Charles A., additional, Yun, Dongsoo, additional, Kar, Swagata, additional, Porto, Maciel, additional, Lok, Megan, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Love, Kerry R., additional, Camp, Danielle L., additional, Silverman, Judith Maxwell, additional, Kleanthous, Harry, additional, Joshi, Sangeeta B., additional, Volkin, David B., additional, Dubois, Patrice M., additional, Collin, Nicolas, additional, King, Neil P., additional, Barouch, Dan H., additional, Irvine, Darrell J., additional, and Love, J. Christopher, additional

Published
2021
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8. A Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO.IL-2Rγc KO. NOD) for COVID-19

Author

Brumeanu, Teodor-D., primary, Vir, Pooja, additional, Karim, Ahmad Faisal, additional, Kar, Swagata, additional, Benetiene, Dalia, additional, Lok, Megan, additional, Greenhouse, Jack, additional, Putmon-Taylor, Tammy, additional, Kitajewski, Christopher, additional, Chung, Kevin K., additional, Pratt, Kathleen P., additional, and Casares, Sofia A., additional

Published
2020
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