Search

Your search keyword '"Lok, A. S. F."' showing total 504 results
Start Over Author "Lok, A. S. F."
504 results on '"Lok, A. S. F."'

3. Toward a Functional Cure for Hepatitis B.

Author

Lok, Anna S. F.

Subjects
*CHRONIC hepatitis B, *HEPATITIS associated antigen, *HEPATITIS B virus, *HEPATIC fibrosis, *HEPATITIS, *ANTIVIRAL agents
Abstract

Current treatment of chronic hepatitis B virus (HBV) infection, pegylated interferon-α (pegIFN-α) and nucleos(t)ide analogue (NA), can suppress HBV replication, reverse liver inflammation and fibrosis, and decrease risks of cirrhosis and hepatocellular carcinoma, but hepatitis B surface antigen (HBsAg) loss is rare. Functional HBV cure is defined as undetectable HBsAg and unquantifiable serum HBV DNA for at least 24 weeks after a finite course of therapy. This requires suppression of HBV replication and viral protein production as well as restoration of immune response to HBV. Direct-acting antivirals targeting virus entry, capsid assembly, viral protein production and secretion are in clinical trials. In parallel, immune modulatory therapies to stimulate HBV-specific immune response and to remove immune blockade are being tested. Clinical trials of direct-acting antivirals alone or immune modulatory therapies alone have not been successful in achieving HBV cure. Recent combinations of direct-acting antivirals and immune modulatory therapies have shown promising results particularly with combinations that included pegIFN-α. These results need to be confirmed in larger studies with longer follow-up, and further work is needed to develop simpler regimens with fewer drugs that can be administered orally and safely. While there is a strong desire to develop finite therapies that can achieve HBV cure, safety is paramount and new therapies must provide incremental value compared to standard of care, which is predominantly long-term NA therapy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Hepatitis B

Author

Jeng, Wen-Juei, primary, Papatheodoridis, George V, additional, and Lok, Anna S F, additional

Published
2023
Full Text
View/download PDF

22. Reply

Author

Ghany, Marc G., primary, King, Wendy C., additional, Lisker‐Melman, Mauricio, additional, Lok, Anna S. F., additional, Terrault, Norah, additional, Janssen, Harry L. A., additional, Khalili, Mandana, additional, Chung, Raymond T., additional, Lee, William M., additional, Lau, Daryl T. Y., additional, Cloherty, Gavin A., additional, and Sterling, Richard K., additional

Published
2021
Full Text
View/download PDF

26. Beyond Utilitarianism: A Method for Analyzing Competing Ethical Principles in a Decision Analysis of Liver Transplantation

Author

Volk, Michael L., Lok, Anna S. F., Ubel, Peter A., and Vijan, Sandeep

Subjects
Care and treatment, Analysis, Research, Ethical aspects, Methods, Liver failure -- Care and treatment -- Research, Decision making -- Ethical aspects -- Analysis -- Methods -- Research, Liver transplantation -- Methods -- Ethical aspects -- Analysis -- Research, Decision-making -- Ethical aspects -- Analysis -- Methods -- Research, Liver -- Transplantation
Published
2008
Full Text
View/download PDF

38. The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference*

Author

Hatzakis, A., Wait, S., Bruix, J., Buti, M., Carballo, M., Cavaleri, M., Colombo, M., Delarocque-Astagneau, E., Dusheiko, G., Esmat, G., Esteban, R., Goldberg, D., Gore, C., Lok, A. S. F., Manns, M., Marcellin, P., Papatheodoridis, G., Peterle, A., Prati, D., Piorkowsky, N., Rizzetto, M., Roudot-Thoraval, F., Soriano, V., Thomas, H. C., Thursz, M., Valla, D., van Damme, P., Veldhuijzen, I. K., Wedemeyer, H., Wiessing, L., Zanetti, A. R., and Janssen, H. L. A.

Published
2011
Full Text
View/download PDF

45. Introduction

Author

Lok, Anna S. F. and Schiff, Eugene R.

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results