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2. Genetic characterization of Angiostrongylus cantonensis isolates from different regions of Ecuador

Author

Solórzano Alava, Luis, primary, Bedoya Pilozo, Cesar, additional, Hernández Alvarez, Hilda, additional, Rodriguez, Misladys, additional, Rojas Rivero, Lazara, additional, Sánchez Amador, Francisco, additional, Muñoz Naranjo, Marcelo, additional, Ramirez, Cecibel, additional, Loja Chango, Rita, additional, Pizarro Velastegui, José, additional, and Loureiro Morasutti, Alessandra, additional

Published
2021
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4. Polymorphism of the THOC5 of the transcription/export multiprotein complex and its correlation with the lipid and metabolic profile in middle-aged women

Author

Loja-Chango, Rita, primary, Salazar-Pousada, Danny, additional, Escobar-Valdivieso, Gustavo S., additional, Ramírez-Morán, Cecibel, additional, Espinoza-Caicedo, Jasson, additional, Pérez-López, Faustino R., additional, Gavilanes, Antonio W. D., additional, and Chedraui, Peter, additional

Published
2019
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6. Polymorphism of the THOC5 of the transcription/export multiprotein complex and its correlation with the lipid and metabolic profile in middle-aged women.

Author

Loja-Chango, Rita, Salazar-Pousada, Danny, Escobar-Valdivieso, Gustavo S., Ramírez-Morán, Cecibel, Espinoza-Caicedo, Jasson, Pérez-López, Faustino R., Gavilanes, Antonio W. D., and Chedraui, Peter

Subjects
*MIDDLE-aged women, *LIPIDS, *MESSENGER RNA, *BLOOD lipids, *METABOLIC syndrome, *TRANSGENIC organisms
Abstract

The transcription/export complex (TREX) is formed by a core called THO. These are necessary for the transcription and packaging of messenger RNA and its subsequent nuclear exportation. Studies have correlated THO-specific polymorphisms with abnormalities of HDL-C metabolism. To correlate lipid and metabolic parameters with the genetic variants of the rs8135828 polymorphism of the THOC5 gene in middle-aged women. DNA was extracted from the whole blood of 183 women aged 40–65 and tested for the rs8135828 polymorphism of the THOC5 gene using real-time PCR. HDL-C, LDL-C, triglyceride, and total cholesterol levels, as well as other metabolic parameters, were correlated with the polymorphism genotypes: GG, AG, and AA. Mean age of women was 50.6 ± 6.3 years, 54.6% were postmenopausal and 16.4% had the metabolic syndrome. GG was the most frequently determined genotype (62.3%). There were no differences in lipid levels according to genotypes; although there was a trend for lower HDL-C levels for the AA and AG + AA genotypes. Those with the AG and AG + AA genotypes displayed significantly higher glucose levels (p =.02 and p =.002, respectively); with a trend toward a higher metabolic syndrome prevalence and increased abdominal perimeters in both variants (AG and AG + AA). The AG genotype was related to higher glucose levels but not with abnormal lipid parameters. There is a need for more research in this regard. [ABSTRACT FROM AUTHOR]

Published
2020
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7. Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador

Author

Bedoya-Pilozo, Cesar H., primary, Medina Magües, Lex G., additional, Espinosa-García, Maylen, additional, Sánchez, Martha, additional, Parrales Valdiviezo, Johanna V., additional, Molina, Denisse, additional, Ibarra, María A., additional, Quimis-Ponce, María, additional, España, Karool, additional, Párraga Macias, Karla E., additional, Cajas Flores, Nancy V., additional, Orlando, Solon A., additional, Robalino Penaherrera, Jorge A., additional, Chedraui, Peter, additional, Escobar, Saul, additional, Loja Chango, Rita D., additional, Ramirez-Morán, Cecibel, additional, Espinoza-Caicedo, Jasson, additional, Sánchez-Giler, Sunny, additional, Limia, Celia M., additional, Alemán, Yoan, additional, Soto, Yudira, additional, Kouri, Vivian, additional, Culasso, Andrés C.A., additional, and Badano, Inés, additional

Published
2018
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