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150 results on '"Loizaga-Iriarte, Ana"'

1. MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics

Author

Gil-Redondo, Rubén, Conde, Ricardo, Bruzzone, Chiara, Seco, Maria Luisa, Bizkarguenaga, Maider, González-Valle, Beatriz, de Diego, Angela, Laín, Ana, Habisch, Hansjörg, Haudum, Christoph, Verheyen, Nicolas, Obermayer-Pietsch, Barbara, Margarita, Sara, Pelusi, Serena, Verde, Ignacio, Oliveira, Nádia, Sousa, Adriana, Zabala-Letona, Amaia, Santos-Martin, Aida, Loizaga-Iriarte, Ana, Unda-Urzaiz, Miguel, Kazenwadel, Jasmin, Berezhnoy, Georgy, Geisler, Tobias, Gawaz, Meinrad, Cannet, Claire, Schäfer, Hartmut, Diercks, Tammo, Trautwein, Christoph, Carracedo, Arkaitz, Madl, Tobias, Valenti, Luca, Spraul, Manfred, Lu, Shelly C., Embade, Nieves, Mato, José M., and Millet, Oscar

Published
2024
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3. METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Author

García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D’Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizabal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023
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4. PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer

Author

Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Fernandez-Ruiz, Sonia, Viera, Cristina, Carlevaris, Onintza, Ercilla, Amaia, Mendizabal, Isabel, Martin, Teresa, Macchia, Alice, Camacho, Laura, Pujana-Vaquerizo, Mikel, Sanchez-Mosquera, Pilar, Torrano, Verónica, Martin-Martin, Natalia, Zuniga-Garcia, Patricia, Castillo-Martin, Mireia, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Unda, Miguel, Mato, Jose M., Berra, Edurne, Martinez-Chantar, Maria L., and Carracedo, Arkaitz

Published
2022
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5. The transcriptional landscape of metastatic hormone-naive prostate cancer

Author

Martin-Martin, Natalia, primary, Garcia-Longarte, Saioa, additional, Corres-Mendizabal, Jon, additional, Lazcano, Uxue, additional, Astobiza, Ianire, additional, Bozal-Basterra, Laura, additional, Herranz, Nicolas, additional, van Splunder, Hielke, additional, Carlevaris, Onintza, additional, Pujana-Vaquerizo, Mikel, additional, Blasco, María Teresa, additional, Aransay, Ana M., additional, Rosino, Antonio, additional, Tudela, Julian, additional, Jimenez, Daniel, additional, Martinez, Alberto, additional, Salca, Andrei, additional, Santos-Martín, Aida, additional, Rey, Sofía, additional, Ugalde-Olano, Aitziber, additional, Gonzalo, David, additional, Graupera, Mariona, additional, Gomis, Roger R., additional, Mateo, Joaquin, additional, Unda, Miguel, additional, Gonzalez-Billalabeitia, Enrique, additional, Loizaga-Iriarte, Ana, additional, Mendizabal, Isabel, additional, and Carracedo, Arkaitz, additional

Published
2024
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6. The Expression of Alamandine Receptor MrgD in Clear Cell Renal Cell Carcinoma Is Associated with a Worse Prognosis and Unfavorable Response to Antiangiogenic Therapy

Author

Enfermería, Fisiología, Biología celular e histología, Erizaintza, Fisiologia, Zelulen biologia eta histologia, Larrinaga Embeita, Gorka, Valdivia Palacin, Asier, Arrieta Aguirre, Inés, Solano Iturri, Jon Danel, Ugalde Olano, Aitziber, Loizaga Iriarte, Ana, Santos Martín, Aida, Pérez Fernández, Amparo, Angulo, Javier C., López Fernández de Villaverde, José Ignacio, Enfermería, Fisiología, Biología celular e histología, Erizaintza, Fisiologia, Zelulen biologia eta histologia, Larrinaga Embeita, Gorka, Valdivia Palacin, Asier, Arrieta Aguirre, Inés, Solano Iturri, Jon Danel, Ugalde Olano, Aitziber, Loizaga Iriarte, Ana, Santos Martín, Aida, Pérez Fernández, Amparo, Angulo, Javier C., and López Fernández de Villaverde, José Ignacio

Abstract

Renal cell carcinoma (RCC) ranks among the most prevalent malignancies in Western countries, marked by its notable heterogeneity, which contributes to an unpredictable clinical trajectory. The insufficiency of dependable biomarkers adds complexity to assessing this tumor progression. Imbalances of several components of the intrarenal renin–angiotensin system (iRAS) significantly impact patient prognoses and responses to first-line immunotherapies. In this study, we analyzed the immunohistochemical expression of the Mas-related G-protein-coupled receptor D (MrgD), which recognizes the novel RAS peptide alamandine (ALA), in a series of 87 clear cell renal cell (CCRCCs), 19 papillary (PRCC), 7 chromophobe (ChRCC) renal cell carcinomas, and 11 renal oncocytomas (RO). MrgD was expressed in all the renal tumor subtypes, with a higher mean staining intensity in the PRCCs, ChRCCs, and ROs. A high expression of MrgD at the tumor center and at the infiltrative front of CCRCC tissues was significantly associated with a high histological grade, large tumor diameter, local invasion, and locoregional node and distant metastasis. Patients with worse 5-year cancer-specific survival and a poorer response to antiangiogenic tyrosine-kinase inhibitors (TKIs) showed higher MrgD expression at the center of their primary tumors. These findings suggest a possible role of MrgD in renal carcinogenetic processes. Further studies are necessary to unveil its potential as a novel biomarker for CCRCC prognosis and response to frontline therapies.

Published
2024

7. The Expression of Alamandine Receptor MrgD in Clear Cell Renal Cell Carcinoma Is Associated with a Worse Prognosis and Unfavorable Response to Antiangiogenic Therapy

Author

Larrinaga, Gorka, primary, Valdivia, Asier, additional, Arrieta-Aguirre, Inés, additional, Solano-Iturri, Jon Danel, additional, Ugalde-Olano, Aitziber, additional, Loizaga-Iriarte, Ana, additional, Santos-Martín, Aida, additional, Pérez-Fernández, Amparo, additional, Angulo, Javier C., additional, and López, José I., additional

Published
2024
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9. METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Author

Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Castilla y León, Universidad de Salamanca, Banco Santander, Asociación Española Contra el Cáncer, Fundación CRIS contra el Cáncer, Fundación la Caixa, European Research Council, European Commission, García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Castilla y León, Universidad de Salamanca, Banco Santander, Asociación Española Contra el Cáncer, Fundación CRIS contra el Cáncer, Fundación la Caixa, European Research Council, European Commission, García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Abstract

Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show that the transfer RNA N7-methylguanosine (m7G) transferase METTL1 is highly expressed in primary and advanced prostate tumours. Mechanistically, we find that METTL1 depletion causes the loss of m7G tRNA methylation and promotes the biogenesis of a novel class of small non-coding RNAs derived from 5'tRNA fragments. 5'tRNA-derived small RNAs steer translation control to favour the synthesis of key regulators of tumour growth suppression, interferon pathway, and immune effectors. Knockdown of Mettl1 in prostate cancer preclinical models increases intratumoural infiltration of pro-inflammatory immune cells and enhances responses to immunotherapy. Collectively, our findings reveal a therapeutically actionable role of METTL1-directed m7G tRNA methylation in cancer cell translation control and tumour biology.

Published
2023

10. Additional file 10 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

11. Additional file 7 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

12. Additional file 8 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

13. Additional file 9 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

14. Additional file 2 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

15. Additional file 3 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

16. Additional file 4 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

17. Additional file 6 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

18. Additional file 5 of METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer [Dataset]

Author

Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, Blanco, Sandra, Consejo Superior de Investigaciones Científicas (España), García-Vílchez, Raquel, Añazco-Guenkova, Ana M., Dietmann, Sabine, López, Judith, Morón-Calvente, Virginia, D'Ambrosi, Silvia, Nombela, Paz, Zamacola, Kepa, Mendizábal, Isabel, García-Longarte, Saioa, Zabala-Letona, Amaia, Astobiza, Ianire, Fernández, Sonia, Paniagua, Alejandro, Miguel-López, Borja, Marchand, Virginie, Alonso-López, Diego, Merkel, Angelika, García-Tuñón, Ignacio, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Azkargorta, Mikel, Elortza, Félix, Bárcena, Laura, Gonzalez-Lopez, Monika, Aransay, Ana M., Di Domenico, Tomás, Sánchez-Martín, Manuel A., De Las Rivas, Javier, Guil, Sònia, Motorin, Yuri, Helm, Mark, Pandolfi, Pier Paolo, Carracedo, Arkaitz, and Blanco, Sandra

Published
2023

19. Data from PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth

Author

Martín-Martín, Natalia, primary, Zabala-Letona, Amaia, primary, Fernández-Ruiz, Sonia, primary, Arreal, Leire, primary, Camacho, Laura, primary, Castillo-Martin, Mireia, primary, Cortazar, Ana R., primary, Torrano, Verónica, primary, Astobiza, Ianire, primary, Zúñiga-García, Patricia, primary, Ugalde-Olano, Aitziber, primary, Loizaga-Iriarte, Ana, primary, Unda, Miguel, primary, Valcárcel-Jiménez, Lorea, primary, Arruabarrena-Aristorena, Amaia, primary, Piva, Marco, primary, Sánchez-Mosquera, Pilar, primary, Aransay, Ana M., primary, Gomez-Muñoz, Antonio, primary, Barrio, Rosa, primary, Sutherland, James D., primary, and Carracedo, Arkaitz, primary

Published
2023
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20. Suppl Figures 1, 2, 3, 4, 5, 6 and legends from PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth

Author

Martín-Martín, Natalia, primary, Zabala-Letona, Amaia, primary, Fernández-Ruiz, Sonia, primary, Arreal, Leire, primary, Camacho, Laura, primary, Castillo-Martin, Mireia, primary, Cortazar, Ana R., primary, Torrano, Verónica, primary, Astobiza, Ianire, primary, Zúñiga-García, Patricia, primary, Ugalde-Olano, Aitziber, primary, Loizaga-Iriarte, Ana, primary, Unda, Miguel, primary, Valcárcel-Jiménez, Lorea, primary, Arruabarrena-Aristorena, Amaia, primary, Piva, Marco, primary, Sánchez-Mosquera, Pilar, primary, Aransay, Ana M., primary, Gomez-Muñoz, Antonio, primary, Barrio, Rosa, primary, Sutherland, James D., primary, and Carracedo, Arkaitz, primary

Published
2023
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21. Suppl Table S1 from PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth

Author

Martín-Martín, Natalia, primary, Zabala-Letona, Amaia, primary, Fernández-Ruiz, Sonia, primary, Arreal, Leire, primary, Camacho, Laura, primary, Castillo-Martin, Mireia, primary, Cortazar, Ana R., primary, Torrano, Verónica, primary, Astobiza, Ianire, primary, Zúñiga-García, Patricia, primary, Ugalde-Olano, Aitziber, primary, Loizaga-Iriarte, Ana, primary, Unda, Miguel, primary, Valcárcel-Jiménez, Lorea, primary, Arruabarrena-Aristorena, Amaia, primary, Piva, Marco, primary, Sánchez-Mosquera, Pilar, primary, Aransay, Ana M., primary, Gomez-Muñoz, Antonio, primary, Barrio, Rosa, primary, Sutherland, James D., primary, and Carracedo, Arkaitz, primary

Published
2023
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22. Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN

Author

Ugalde-Olano, Aitziber, Egia, Ainara, Fernández-Ruiz, Sonia, Loizaga-Iriarte, Ana, Zuñiga-García, Patricia, Garcia, Stephane, Royo, Félix, Lacasa-Viscasillas, Isabel, Castro, Erika, Cortazar, Ana R., Zabala-Letona, Amaia, Martín-Martín, Natalia, Arruabarrena-Aristorena, Amaia, Torrano-Moya, Verónica, Valcárcel-Jiménez, Lorea, Sánchez-Mosquera, Pilar, Caro-Maldonado, Alfredo, González-Tampan, Jorge, Cachi-Fuentes, Guido, Bilbao, Elena, Montero, Rocío, Fernández, Sara, Arrieta, Edurne, Zorroza, Kerman, Castillo-Martín, Mireia, Serra, Violeta, Salazar, Eider, Macías-Cámara, Nuria, Tabernero, Jose, Baselga, Jose, Cordón-Cardo, Carlos, Aransay, Ana M., Villar, Amaia Del, Iovanna, Juan L., Falcón-Pérez, Juan M., Unda, Miguel, Bilbao, Roberto, and Carracedo, Arkaitz

Published
2015
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23. MetSCORE: A Molecular Metric to Evaluate the Risk of Metabolic Syndrome Based on Serum NMR Metabolomics

Author

Gil-Redondo, Rubén, primary, Conde, Ricardo, additional, Bruzzone, Chiara, additional, Seco, Marisa, additional, Bizkarguenaga, Maider, additional, González-Valle, Beatriz, additional, de Diego, Angela, additional, Laín, Ana, additional, Habisch, Hansjörg, additional, Haudum, Christoph, additional, Verheyen, Nicolas, additional, Obermayer-Pietsch, Barbara, additional, Margarita, Sara, additional, Pelusi, Serena, additional, Verde, Ignacio, additional, Oliveira, Nádia, additional, Sousa, Adriana, additional, Zabala-Letona, Amaia, additional, Santos-Martin, Aida, additional, Loizaga-Iriarte, Ana, additional, Unda-Urzaiz, Miguel, additional, Kazenwadel, Jasmin, additional, Bereznoy, Georgy, additional, Geisler, Tobias, additional, Gawaz, Meinrad, additional, Cannet, Claire, additional, Schäfer, Hartmut, additional, Diercks, Tammo, additional, Trautwein, Christoph, additional, Carracedo, Arkaitz, additional, Madl, Tobias, additional, Valenti, Luca, additional, Spraul, Manfred, additional, Lu, Shelly C., additional, Embade, Nieves, additional, Mato, José M., additional, and Millet, Oscar, additional

Published
2023
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24. Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer

Author

Valcarcel-Jimenez, Lorea, Macchia, Alice, Martín-Martín, Natalia, Cortazar, Ana Rosa, Schaub-Clerigué, Ariane, Pujana-Vaquerizo, Mikel, Fernández-Ruiz, Sonia, Lacasa-Viscasillas, Isabel, Santos-Martin, Aida, Loizaga-Iriarte, Ana, Unda-Urzaiz, Miguel, Hermanova, Ivana, Astobiza, Ianire, Graupera, Mariona, Starkova, Julia, Sutherland, James, Barrio, Rosa, Aransay, Ana M., Carracedo, Arkaitz, and Torrano, Verónica

Published
2018
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25. The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Author

Torrano, Veronica, Valcarcel-Jimenez, Lorea, Cortazar, Ana Rosa, Liu, Xiaojing, Urosevic, Jelena, Castillo-Martin, Mireia, Fernández-Ruiz, Sonia, Morciano, Giampaolo, Caro-Maldonado, Alfredo, Guiu, Marc, Zúñiga-García, Patricia, Graupera, Mariona, Bellmunt, Anna, Pandya, Pahini, Lorente, Mar, Martín-Martín, Natalia, Sutherland, James David, Sanchez-Mosquera, Pilar, Bozal-Basterra, Laura, Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Berenguer, Antonio, Embade, Nieves, Ugalde-Olano, Aitziber, Lacasa-Viscasillas, Isabel, Loizaga-Iriarte, Ana, Unda-Urzaiz, Miguel, Schultz, Nikolaus, Aransay, Ana Maria, Sanz-Moreno, Victoria, Barrio, Rosa, Velasco, Guillermo, Pinton, Paolo, Cordon-Cardo, Carlos, Locasale, Jason W., Gomis, Roger R., and Carracedo, Arkaitz

Published
2016
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26. PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer

Author

Bioquímica y biología molecular, Cirugía, radiología y medicina física, Biokimika eta biologia molekularra, Kirurgia,erradiologia eta medikuntza fisikoa, Zabala Letona, Amaia, Arruabarrena Aristorena, Amaia, Fernández Ruiz, Sonia, Viera, Cristina, Carlevaris, Onintza, Ercilla Eguiarte, Amaia, Mendizabal, Isabel, Martín Mateos, Teresa, Macchia, Alice, Camacho Soguero, Laura, Pujana Vaquerizo, Mikel, Sánchez Mosquera, Pilar, Torrano Moya, Verónica, Martín Martín, Natalia, Zuñiga García, Patricia, Castillo Martín, Mireia, Ugalde Olano, Aitziber, Loizaga Iriarte, Ana, Unda Urzaiz, Jesús Miguel, Mato, José M., Berra Ramírez, Miren Edurne, Martínez Chantar, María Luz, Carracedo Pérez, Arkaitz, Bioquímica y biología molecular, Cirugía, radiología y medicina física, Biokimika eta biologia molekularra, Kirurgia,erradiologia eta medikuntza fisikoa, Zabala Letona, Amaia, Arruabarrena Aristorena, Amaia, Fernández Ruiz, Sonia, Viera, Cristina, Carlevaris, Onintza, Ercilla Eguiarte, Amaia, Mendizabal, Isabel, Martín Mateos, Teresa, Macchia, Alice, Camacho Soguero, Laura, Pujana Vaquerizo, Mikel, Sánchez Mosquera, Pilar, Torrano Moya, Verónica, Martín Martín, Natalia, Zuñiga García, Patricia, Castillo Martín, Mireia, Ugalde Olano, Aitziber, Loizaga Iriarte, Ana, Unda Urzaiz, Jesús Miguel, Mato, José M., Berra Ramírez, Miren Edurne, Martínez Chantar, María Luz, and Carracedo Pérez, Arkaitz

Abstract

[EN] Glycine N-Methyltransferase (GNMT) is a metabolic enzyme that integrates metabolism and epigenetic regulation. The product of GNMT, sarcosine, has been proposed as a prostate cancer biomarker. This enzyme is predominantly expressed in the liver, brain, pancreas, and prostate tissue, where it exhibits distinct regulation. Whereas genetic alterations in GNMT have been associated to prostate cancer risk, its causal contribution to the development of this disease is limited to cell line-based studies and correlative human analyses. Here we integrate human studies, genetic mouse modeling, and cellular systems to characterize the regulation and function of GNMT in prostate cancer. We report that this enzyme is repressed upon activation of the oncogenic Phosphoinositide-3-kinase (PI3K) pathway, which adds complexity to its reported dependency on androgen signaling. Importantly, we demonstrate that expression of GNMT is required for the onset of invasive prostate cancer in a genetic mouse model. Altogether, our results provide further support of the heavy oncogenic signal-dependent regulation of GNMT in prostate cancer.

Published
2022

27. Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Author

Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Martn-Martn, Natalia, Fernandez-Ruiz, Sonia, Sutherland, James D., Clasquin, Michelle, Tomas-Cortazar, Julen, Jimenez, Jose, Torres, Ines, Quang, Phong, Ximenez-Embun, Pilar, Bago, Ruzica, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Torrano, Vernica, Cabrera, Diana, van Liempd, Sebastiaan M., Cendon, Ylenia, Castro, Elena, Murray, Stuart, Revandkar, Ajinkya, Alimonti, Andrea, Zhang, Yinan, Barnett, Amelia, Lein, Gina, Pirman, David, Cortazar, Ana R., Arreal, Leire, Prudkin, Ludmila, Astobiza, Ianire, Valcarcel-Jimenez, Lorea, Zuiga-Garca, Patricia, Fernandez-Dominguez, Itziar, Piva, Marco, Caro-Maldonado, Alfredo, Snchez-Mosquera, Pilar, Castillo-Martn, Mireia, Serra, Violeta, Beraza, Naiara, Gentilella, Antonio, Thomas, George, Azkargorta, Mikel, Elortza, Felix, Farrs, Rosa, Olmos, David, Efeyan, Alejo, Anguita, Juan, Muoz, Javier, Falcn-Prez, Juan M., Barrio, Rosa, Macarulla, Teresa, Mato, Jose M., Martinez-Chantar, Maria L., Cordon-Cardo, Carlos, Aransay, Ana M., Marks, Kevin, Baselga, Jos, Tabernero, Josep, Nuciforo, Paolo, Manning, Brendan D., Marjon, Katya, and Carracedo, Arkaitz

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Amaia Zabala-Letona; Amaia Arruabarrena-Aristorena; Natalia Martn-Martn; Sonia Fernandez-Ruiz; James D. Sutherland; Michelle Clasquin; Julen Tomas-Cortazar; Jose Jimenez; Ines Torres; Phong Quang; Pilar Ximenez-Embun; Ruzica Bago; Aitziber Ugalde-Olano; Ana Loizaga-Iriarte; [...]

Published
2018
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29. Active Surveillance for Prostate Cancer as treatment modality: experience at Basurto University Hospital

Author

Loizaga Iriarte, Ana, F. MEDICINA Y ODONTOLOGIA, MEDIKUNTZA ETA ODONTOLOGIA F., Redondo Herrera, Xabier, Loizaga Iriarte, Ana, F. MEDICINA Y ODONTOLOGIA, MEDIKUNTZA ETA ODONTOLOGIA F., and Redondo Herrera, Xabier

Abstract

[EN] Introduction: Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer death in men worldwide. Different treatment modalities are available for low-risk localized PC, one of them being Active Surveillance,which is defined as a monitoring strategy for patients with prostatecancer with the aim of deferring curative treatment.Several protocols have been proposed.Materials and methods:This study includes all patients diagnosed with PC that have undergone or currently undergo AS as treatment modality at Basurto University Hospital between September 2014 and March 2019.Once a database was designed and data was collected, descriptive and comparative (variables related to progression) analyses wereperformed.Results:These variables were notrelated to PC progression: age at diagnosis, BMI, ECOG, PC family history, alpha-blockers, statins, total PSA, PSA density, F/T PSA, clinical stage, number of previous biopsies, percentage of positive cylinders, larger lengthaffecting a cylinder, HGPIN, ASAP, IIEF score. CCI score (a higher score was seen on patients that had progressed)was related to progression, and lose of QOL after RRP (measured using IIEF) was proved.Conclusions:Astrict selection of patients should be done when considering AS as a treatment option, specially focusing on the estimated 10-year survival. Additionally, the deferral of active treatment can be justified by seeing the results obtained regarding QOL deterioration after RRP.The results of this study should be further studiedby extending this study and including more patients into it.Furthermore, longer follow-up is needed in order to know oncological outcomes.

Published
2021

30. Clinical Implications of (Pro)renin Receptor (PRR) Expression in Renal Tumours

Author

Fisiología, Enfermería, Fisiologia, Erizaintza, Solano Iturri, Jon Danel, Echevarría Orella, Enrique, Unda Urzaiz, Jesús Miguel, Loizaga Iriarte, Ana, Pérez Fernández, Amparo, Angulo, Javier C., López Fernández de Villaverde, José Ignacio, Larrinaga Embeita, Gorka, Fisiología, Enfermería, Fisiologia, Erizaintza, Solano Iturri, Jon Danel, Echevarría Orella, Enrique, Unda Urzaiz, Jesús Miguel, Loizaga Iriarte, Ana, Pérez Fernández, Amparo, Angulo, Javier C., López Fernández de Villaverde, José Ignacio, and Larrinaga Embeita, Gorka

Abstract

(1) Background: Renal cancer is one of the most frequent malignancies in Western countries, with an unpredictable clinical outcome, partly due to its high heterogeneity and the scarcity of reliable biomarkers of tumour progression. (Pro)renin receptor (PRR) is a novel receptor of the renin–angiotensin system (RAS) that has been associated with the development and progression of some solid tumours by RAS-dependent and -independent mechanisms. (2) Methods: In this study, we analysed the immunohistochemical expression of PRR at the centre and border in a series of 83 clear-cell renal cell (CCRCCs), 19 papillary (PRCC) and 7 chromophobe (ChRCC) renal cell carcinomas, and the benign tumour renal oncocytoma (RO, n = 11). (3) Results: PRR is expressed in all the tumour subtypes, with higher mean staining intensity in ChRCCs and ROs. A high expression of PRR at the tumour centre and at the infiltrative front of CCRCC tissues is significantly associated with high grade, tumour diameter, local invasion and stage, and with high mortality risk by UCLA integrated staging system (UISS) scale. (4) Conclusions: These findings indicate that PRR is associated with the development and progression of renal tumours. Its potential as a novel biomarker for RCC diagnosis/prognosis and as a promising therapeutic target should be taken into account in the future.

Published
2021

31. Soluble PD-L1 Is an Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma

Author

Enfermería, Fisiología, Especialidades médico-quirúrgicas, Biología celular e histología, Erizaintza, Fisiologia, Medikuntza eta kirurgia espezialitateak, Zelulen biologia eta histologia, Larrinaga Embeita, Gorka, Solano Iturri, Jon Danel, Errarte Yarza, Peio, Unda Urzaiz, Jesús Miguel, Loizaga Iriarte, Ana, Pérez Fernández, Amparo, Echevarría Orella, Enrique, Asumendi Mallea, Aintzane, Manini, Claudia, Angulo, Javier C., López Fernández de Villaverde, José Ignacio, Enfermería, Fisiología, Especialidades médico-quirúrgicas, Biología celular e histología, Erizaintza, Fisiologia, Medikuntza eta kirurgia espezialitateak, Zelulen biologia eta histologia, Larrinaga Embeita, Gorka, Solano Iturri, Jon Danel, Errarte Yarza, Peio, Unda Urzaiz, Jesús Miguel, Loizaga Iriarte, Ana, Pérez Fernández, Amparo, Echevarría Orella, Enrique, Asumendi Mallea, Aintzane, Manini, Claudia, Angulo, Javier C., and López Fernández de Villaverde, José Ignacio

Abstract

(1). Background: Immunohistochemical (IHC) evaluation of programmed death-1 (PD-1) and its ligand (PD-L1) is being used to evaluate advanced malignancies with potential response to immune checkpoint inhibitors. We evaluated both plasma and tissue expression of PD-1 and PD-L1 in the same cohort of patients, including non-metastatic and metastatic clear cell renal cell carcinoma (CCRCC). Concomitant plasma and tissue expression of PD-1 and PD-L1 was evaluated with emphasis on diagnostic and prognostic implications. (2) Methods: we analyzed PD-1 and PD-L1 IHC expression in tumor tissues and soluble forms (sPD-1 and sPD-L1) in plasma from 89 patients with CCRCC, of which 23 were metastatic and 16 received systemic therapy. The primary endpoint was evaluation of overall survival using Kaplan-Meier analysis and the Cox regression model. Plasma samples from healthy volunteers were also evaluated. (3) Results: Interestingly, sPD-1 and sPD-L1 levels were lower in cancer patients than in controls. sPD-1 and sPD-L1 levels and their counterpart tissue expression both at the tumor center and infiltrating front were not associated. Higher expression of both PD-1 and PD-L1 were associated with tumor grade, necrosis and tumor size. PD-1 was associated to tumor stage (pT) and PD-L1 to metastases. sPD-1 and sPD-L1 were not associated with clinico-pathological parameters, although both were higher in patients with synchronous metastases compared to metachronous ones and sPD-L1 was also higher for metastatic patients compared to non-metastatic patients. sPD-1 was also associated with the International Metastatic Renal Cell Cancer Database Consortium (IMDC) prognostic groups in metastatic CCRCC and also to the Morphology, Attenuation, Size and Structure (MASS) response criteria in metastatic patients treated with systemic therapy, mainly tyrosine-kinase inhibitors. Regarding prognosis, PD-L1 immunostaining at the tumor center with and without the tumor front was associated with worse su

Published
2021

32. Estudio comparativo de las características del cáncer de próstata metastásico de inicio o tras evolución de cáncer localizado

Author

Loizaga Iriarte, Ana, F. MEDICINA Y ODONTOLOGIA, MEDIKUNTZA ETA ODONTOLOGIA F., Medicina, Etxebarria Bahillo, Leire, Loizaga Iriarte, Ana, F. MEDICINA Y ODONTOLOGIA, MEDIKUNTZA ETA ODONTOLOGIA F., Medicina, and Etxebarria Bahillo, Leire

Abstract

[ES]Introducción: El cáncer de próstata se considera el tumor más frecuente diagnosticado en varones tanto en España como en la Comunidad Autónoma Vasca (CAV). Se trata de un tumor andrógeno dependiente, se caracteriza por su alta heterogeneidad y por su aparición sobre todo a partir de los 50 años. // Objetivos: La valoración de las posibles diferencias de los pacientes con cáncer de próstata avanzado metastásico y el desarrollo de herramientas que permitan diferenciar de manera precoz la enfermedad agresiva de la indolente. // Material y métodos: Estudio retrospectivo de una cohorte de 59 pacientes con cáncer de próstata avanzado metastásico, diferenciados en 2 grupos: los pacientes con cáncer de próstata localizado intervenido por prostatectomía radical robótica que progresan a metastásicos y los pacientes diagnosticados de cáncer de próstata metastásico de inicio. Se realiza un estudio comparativo de las características clínicas, epidemiológicas y analíticas de ambos grupos de pacientes. // Resultados: En cuanto a los antecedentes personales y familiares de los pacientes no se encuentran diferencias significativas entre ambos grupos. Se observa una clara diferencia entre los valores de PSA de ambas enfermedades metastásicas a lo largo de su evolución. Las características de la biopsia indican un peor pronóstico en los metastásicos de inicio, pero sin significación estadística. Respecto a los factores analíticos, destacar la elevación de los linfocitos y de la fosfatasa alcalina en pacientes metastásicos de inicio de manera significativa. Se observa una diferencia significativa en los M1 de debut, en cuanto a presentar >5 metástasis óseas, mayoritariamente fuera del axis. Por último, el tiempo a resistencia a la castración y el tiempo a fallecimiento son estadísticamente menores en los varones metastásicos de inicio. Conclusiones: Se observa un menor tiempo de supervivencia y de tiempo a resistencia a la castración, junto con una mayor carga metastásica ósea en l

Published
2021

33. mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Author

Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Martn-Martn, Natalia, Fernandez-Ruiz, Sonia, Sutherland, James D., Clasquin, Michelle, Tomas-Cortazar, Julen, Jimenez, Jose, Torres, Ines, Quang, Phong, Ximenez-Embun, Pilar, Bago, Ruzica, Ugalde-Olano, Aitziber, Loizaga-Iriarte, Ana, Lacasa-Viscasillas, Isabel, Unda, Miguel, Torrano, Vernica, Cabrera, Diana, van Liempd, Sebastiaan M., Cendon, Ylenia, Castro, Elena, Murray, Stuart, Revandkar, Ajinkya, Alimonti, Andrea, Zhang, Yinan, Barnett, Amelia, Lein, Gina, Pirman, David, Cortazar, Ana R., Arreal, Leire, Prudkin, Ludmila, Astobiza, Ianire, Valcarcel-Jimenez, Lorea, Zuiga-Garca, Patricia, Fernandez-Dominguez, Itziar, Piva, Marco, Caro-Maldonado, Alfredo, Snchez-Mosquera, Pilar, Castillo-Martn, Mireia, Serra, Violeta, Beraza, Naiara, Gentilella, Antonio, Thomas, George, Azkargorta, Mikel, Elortza, Felix, Farrs, Rosa, Olmos, David, Efeyan, Alejo, Anguita, Juan, Muoz, Javier, Falcn-Prez, Juan M., Barrio, Rosa, Macarulla, Teresa, Mato, Jose M., Martinez-Chantar, Maria L., Cordon-Cardo, Carlos, Aransay, Ana M., Marks, Kevin, Baselga, Jos, Tabernero, Josep, Nuciforo, Paolo, Manning, Brendan D., Marjon, Katya, and Carracedo, Arkaitz

Subjects
Polyamines -- Physiological aspects, Prostate cancer -- Physiological aspects, S-adenosylmethionine -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Amaia Zabala-Letona [1, 2]; Amaia Arruabarrena-Aristorena [1]; Natalia Martn-Martn [1, 2]; Sonia Fernandez-Ruiz [1, 2]; James D. Sutherland [1]; Michelle Clasquin [3]; Julen Tomas-Cortazar [1]; Jose Jimenez [4]; Ines [...]

Published
2017
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36. 1H NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer

Author

Bruzzone, Chiara, primary, Loizaga-Iriarte, Ana, additional, Sánchez-Mosquera, Pilar, additional, Gil-Redondo, Rubén, additional, Astobiza, Ianire, additional, Diercks, Tammo, additional, Cortazar, Ana R., additional, Ugalde-Olano, Aitziber, additional, Schäfer, Hartmut, additional, Blanco, Francisco J., additional, Unda, Miguel, additional, Cannet, Claire, additional, Spraul, Manfred, additional, Mato, José M., additional, Embade, Nieves, additional, Carracedo, Arkaitz, additional, and Millet, Oscar, additional

Published
2020
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37. The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer

Author

Solé, Carla, primary, Goicoechea, Ibai, additional, Goñi, Alai, additional, Schramm, Maike, additional, Armesto, María, additional, Arestin, María, additional, Manterola, Lorea, additional, Tellaetxe, Maitena, additional, Alberdi, Aitor, additional, Nogueira, Leonor, additional, Roumiguie, Mathieu, additional, López, Jose Ignacio, additional, Sanz Jaka, Juan Pablo, additional, Urruticoechea, Ander, additional, Vergara, Itziar, additional, Loizaga-Iriarte, Ana, additional, Unda, Miguel, additional, Carracedo, Arkaitz, additional, Malavaud, Bernard, additional, and Lawrie, Charles H., additional

Published
2020
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38. Diseño y explotación de un circuito de investigación traslacional en cáncer de próstata

Author

Loizaga Iriarte, Ana and Carracedo Pérez, Arkaitz

Subjects
urologic surgery, cirugía urológica
Abstract

424 p. La investigación clínica no basta por sí sola. Resulta imprescindible su interrelación con la investigación básica. El biobanco es un nexo de unión. Existe una falta de estructura en la adquisición y manejo de datos relacionados con patologías y pacientes. Esta falta de integración de datos limita nuestro conocimiento sobre factores que influyen en la enfermedad. El cáncer de próstata representa el cáncer más prevalente en el varón. El incremento anual esperado es un 3-4% anual. Su presentación varía desde indolente a mortal. Por otra parte, su tratamiento implica una pérdida importante de calidad de vida. Conocer en el momento del diagnóstico a qué tipo de tumor nos enfrentamos podría evitar tratamientos innecesarios o determinar un tratamiento multimodal intenso de manera precoz.Objetivo: 1 Diseño de un circuito de investigación traslacional en un Servicio de Urología para la búsqueda experimental de biomarcadores no invasivos en cáncer de próstata. 2 Diseño de protocolo clínico y de recogida de datos de pacientes con prostatectomía radical robótica y búsqueda de factores pronósticos clínicos.Material y Métodos: Estudio clínico prospectivo de 1148 pacientes intervenidos de prostatectomía radical robótica por cáncer de próstata. Revisión de la literatura para la definición de factores pronósticos en cohorte entre 2009 y 2014 con un seguimiento de 5 años. Creación de un circuito de investigación para inclusión en biobanco de biofluidos y tejido prostático de pacientes con cáncer de próstata y de casos control con hiperplasia benigna de próstata para estudios moleculares a partir de 2012. Resultados: Protocolo de actividad traslacional sobre cáncer de próstata implantado en la rutina diaria de un Servicio de Urología distribuido a lo largo de citas concertadas el día del diagnóstico, día de la programación quirúrgica, día anterior a la cirugía, día de la cirugía y seguimiento posterior que ocupan un total de 20 minutos al paciente y 30 minutos al urólogo/a especializado en cáncer de próstata, enfermería y auxiliares. Diseño de base de datos en plataforma online. Análisis de los datos clínicos de la cohorte y obtención de factores pronósticos de la misma. Se investigan factores de antecedentes del paciente, factores del tumor previos a la cirugía, factores de la técnica, factores de la pieza quirúrgica, factores de anatomía patológica y factores de calidad de vida. Estos resultados son la base de estudios moleculares en los pacientes seleccionados con factores de mal pronóstico.Conclusiones: La integración de la plataforma clínica, biobanco e investigadores básicos nos ha permitido a un hospital terciario participar en el desarrollo de biomarcadores no invasivos seleccionando los grupos de pacientes de mal pronóstico. Se describe un nuevo score pronóstico añadiendo la bilateralidad de la biopsia, ISUP ¿3; porcentaje de tumor en el cilindro afectado >30% e invasión perineural asociada a linfovascular. CICbioGUNE

Published
2020

39. Diseño y explotación de un circuito de investigación traslacional en cáncer de próstata

Author

Carracedo Pérez, Arkaitz, Bioquímica y biología molecular, Biokimika eta biologia molekularra, Loizaga Iriarte, Ana, Carracedo Pérez, Arkaitz, Bioquímica y biología molecular, Biokimika eta biologia molekularra, and Loizaga Iriarte, Ana

Abstract

424 p., La investigación clínica no basta por sí sola. Resulta imprescindible su interrelación con la investigación básica. El biobanco es un nexo de unión. Existe una falta de estructura en la adquisición y manejo de datos relacionados con patologías y pacientes. Esta falta de integración de datos limita nuestro conocimiento sobre factores que influyen en la enfermedad. El cáncer de próstata representa el cáncer más prevalente en el varón. El incremento anual esperado es un 3-4% anual. Su presentación varía desde indolente a mortal. Por otra parte, su tratamiento implica una pérdida importante de calidad de vida. Conocer en el momento del diagnóstico a qué tipo de tumor nos enfrentamos podría evitar tratamientos innecesarios o determinar un tratamiento multimodal intenso de manera precoz.Objetivo: 1 Diseño de un circuito de investigación traslacional en un Servicio de Urología para la búsqueda experimental de biomarcadores no invasivos en cáncer de próstata. 2 Diseño de protocolo clínico y de recogida de datos de pacientes con prostatectomía radical robótica y búsqueda de factores pronósticos clínicos.Material y Métodos: Estudio clínico prospectivo de 1148 pacientes intervenidos de prostatectomía radical robótica por cáncer de próstata. Revisión de la literatura para la definición de factores pronósticos en cohorte entre 2009 y 2014 con un seguimiento de 5 años. Creación de un circuito de investigación para inclusión en biobanco de biofluidos y tejido prostático de pacientes con cáncer de próstata y de casos control con hiperplasia benigna de próstata para estudios moleculares a partir de 2012. Resultados: Protocolo de actividad traslacional sobre cáncer de próstata implantado en la rutina diaria de un Servicio de Urología distribuido a lo largo de citas concertadas el día del diagnóstico, día de la programación quirúrgica, día anterior a la cirugía, día de la cirugía y seguimiento posterior que ocupan un total de 20 minutos al paciente y 30 minutos al urólogo/a especializ

Published
2020

41. Integrative analysis of transcriptomic and clinical data uncovers the tumor suppressive activity of MITF in prostate cancer

Author

Valcarcel-Jimenez, Lorea, primary, Macchia, Alice, additional, Martín-Martín, Natalia, additional, Cortazar, Ana Rosa, additional, Schaub-Clerigué, Ariane, additional, Pujana-Vaquerizo, Mikel, additional, Fernández-Ruiz, Sonia, additional, Lacasa-Viscasillas, Isabel, additional, Santos-Martin, Aida, additional, Loizaga-Iriarte, Ana, additional, Unda-Urzaiz, Miguel, additional, Hermanova, Ivana, additional, Astobiza, lanire, additional, Graupera, Mariona, additional, Starkova, Julia, additional, Sutherland, James, additional, Barrio, Rosa, additional, Aransay, Ana M., additional, Carracedo, Arkaitz, additional, and Torrano, Verónica, additional

Published
2018
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42. Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression

Author

Clos-Garcia, Marc, primary, Loizaga-Iriarte, Ana, additional, Zuñiga-Garcia, Patricia, additional, Sánchez-Mosquera, Pilar, additional, Rosa Cortazar, Ana, additional, González, Esperanza, additional, Torrano, Verónica, additional, Alonso, Cristina, additional, Pérez-Cormenzana, Miriam, additional, Ugalde-Olano, Aitziber, additional, Lacasa-Viscasillas, Isabel, additional, Castro, Azucena, additional, Royo, Felix, additional, Unda, Miguel, additional, Carracedo, Arkaitz, additional, and Falcón-Pérez, Juan M., additional

Published
2018
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43. Integrative Analysis of Transcriptomics and Clinical Data Uncovers the Tumor- Suppressive Activity of MITF in Prostate Cancer

Author

Bioquímica y biología molecular, Cirugía, radiología y medicina física, Biokimika eta biologia molekularra, Kirurgia,erradiologia eta medikuntza fisikoa, Valcárcel Jiménez, Lorea, Macchia, Alice, Martín Martín, Natalia, Cortazar, Ana Rosa, Schaub Clerigué, Ariane, Pujana Vaquerizo, Mikel, Fernández Ruiz, Sonia, Lacasa Viscasillas, Isabel, Santos Martín, Aida, Loizaga Iriarte, Ana, Unda Urzaiz, Jesús Miguel, Hermanova, Ivana, Astobiza Pérez, Janire, Graupera, Mariona, Julia, Starkova, Sutherland, James D., Barrio Olano, María Rosa, Aransay Bañares, Ana María, Carracedo Pérez, Arkaitz, Torrano Moya, Verónica, Bioquímica y biología molecular, Cirugía, radiología y medicina física, Biokimika eta biologia molekularra, Kirurgia,erradiologia eta medikuntza fisikoa, Valcárcel Jiménez, Lorea, Macchia, Alice, Martín Martín, Natalia, Cortazar, Ana Rosa, Schaub Clerigué, Ariane, Pujana Vaquerizo, Mikel, Fernández Ruiz, Sonia, Lacasa Viscasillas, Isabel, Santos Martín, Aida, Loizaga Iriarte, Ana, Unda Urzaiz, Jesús Miguel, Hermanova, Ivana, Astobiza Pérez, Janire, Graupera, Mariona, Julia, Starkova, Sutherland, James D., Barrio Olano, María Rosa, Aransay Bañares, Ana María, Carracedo Pérez, Arkaitz, and Torrano Moya, Verónica

Abstract

The dysregulation of gene expression is an enabling hallmark of cancer. Computational analysis of transcriptomics data from human cancer specimens, complemented with exhaustive clinical annotation, provides an opportunity to identify core regulators of the tumorigenic process. Here we exploit well-annotated clinical datasets of prostate cancer for the discovery of transcriptional regulators relevant to prostate cancer. Following this rationale, we identify Microphthalmia-associated transcription factor (MITF) as a prostate tumor suppressor among a subset of transcription factors. Importantly, we further interrogate transcriptomics and clinical data to refine MITF perturbation-based empirical assays and unveil Crystallin Alpha B (CRYAB) as an unprecedented direct target of the transcription factor that is, at least in part, responsible for its tumor-suppressive activity in prostate cancer. This evidence was supported by the enhanced prognostic potential of a signature based on the concomitant alteration of MITF and CRYAB in prostate cancer patients. In sum, our study provides proof-of-concept evidence of the potential of the bioinformatics screen of publicly available cancer patient databases as discovery platforms, and demonstrates that the MITF-CRYAB axis controls prostate cancer biology.

Published
2018

44. Metabolic alterations in urine extracellular vesicles are associated to prostate cancer pathogenesis and progression

Author

Bioquímica y biología molecular, Biokimika eta biologia molekularra, Clos-Garcia, Marc, Loizaga Iriarte, Ana, Zuñiga García, Patricia, Sánchez Mosquera, Pilar, Cortázar, Ana Rosa, González, Esperanza, Verónica Torrano, Alonso, Cristina, Pérez Cormenzana, Miriam, Ugalde Olano, Aitziber, Lacasa Viscasillas, Isabel, Castro, Azucena, Royo, Félix, Unda Urzaiz, Jesús Miguel, Carracedo Pérez, Arkaitz, Falcón Pérez, Juan Manuel, Bioquímica y biología molecular, Biokimika eta biologia molekularra, Clos-Garcia, Marc, Loizaga Iriarte, Ana, Zuñiga García, Patricia, Sánchez Mosquera, Pilar, Cortázar, Ana Rosa, González, Esperanza, Verónica Torrano, Alonso, Cristina, Pérez Cormenzana, Miriam, Ugalde Olano, Aitziber, Lacasa Viscasillas, Isabel, Castro, Azucena, Royo, Félix, Unda Urzaiz, Jesús Miguel, Carracedo Pérez, Arkaitz, and Falcón Pérez, Juan Manuel

Abstract

Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have previously identified proteins and RNAs with differential abundance in urinary EVs from prostate cancer (PCa) patients compared to benign prostate hyperplasia (BPH). Here, we focused on the analysis of the metabolites contained in urinary EVs collected from patients with PCa and BPH. Targeted metabolomics analysis of EVs was performed by ultrahigh- performance liquid chromatography-mass spectrometry. The correlation between metabolites and clinical parameters was studied, and metabolites with differential abundance in PCa urinary EVs were detected and mapped into cellular pathways. We detected 248 metabolites belonging to different chemical families including amino acids and various lipid species. Among these metabolites, 76 exhibited significant differential abundance between PCa and BPH. Interestingly, urine EVs recapitulated many of the metabolic alterations reported in PCa, including phosphathidylcholines, acyl carnitines, citrate and kynurenine. Importantly, we found elevated levels of the steroid hormone, 3beta-hydroxyandros-5-en-17-one-3-sulphate (dehydroepiandrosterone sulphate) in PCa urinary EVs, in line with the potential elevation of androgen synthesis in this type of cancer. This work supports urinary EVs as a non-invasive source to infer metabolic changes in PCa.

Published
2018

45. Erratum: Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Author

Zabala-Letona, Amaia, primary, Arruabarrena-Aristorena, Amaia, additional, Martín-Martín, Natalia, additional, Fernandez-Ruiz, Sonia, additional, Sutherland, James D., additional, Clasquin, Michelle, additional, Tomas-Cortazar, Julen, additional, Jimenez, Jose, additional, Torres, Ines, additional, Quang, Phong, additional, Ximenez-Embun, Pilar, additional, Bago, Ruzica, additional, Ugalde-Olano, Aitziber, additional, Loizaga-Iriarte, Ana, additional, Lacasa-Viscasillas, Isabel, additional, Unda, Miguel, additional, Torrano, Verónica, additional, Cabrera, Diana, additional, van Liempd, Sebastiaan M., additional, Cendon, Ylenia, additional, Castro, Elena, additional, Murray, Stuart, additional, Revandkar, Ajinkya, additional, Alimonti, Andrea, additional, Zhang, Yinan, additional, Barnett, Amelia, additional, Lein, Gina, additional, Pirman, David, additional, Cortazar, Ana R., additional, Arreal, Leire, additional, Prudkin, Ludmila, additional, Astobiza, Ianire, additional, Valcarcel-Jimenez, Lorea, additional, Zuñiga-García, Patricia, additional, Fernandez-Dominguez, Itziar, additional, Piva, Marco, additional, Caro-Maldonado, Alfredo, additional, Sánchez-Mosquera, Pilar, additional, Castillo-Martín, Mireia, additional, Serra, Violeta, additional, Beraza, Naiara, additional, Gentilella, Antonio, additional, Thomas, George, additional, Azkargorta, Mikel, additional, Elortza, Felix, additional, Farràs, Rosa, additional, Olmos, David, additional, Efeyan, Alejo, additional, Anguita, Juan, additional, Muñoz, Javier, additional, Falcón-Pérez, Juan M., additional, Barrio, Rosa, additional, Macarulla, Teresa, additional, Mato, Jose M., additional, Martinez-Chantar, Maria L., additional, Cordon-Cardo, Carlos, additional, Aransay, Ana M., additional, Marks, Kevin, additional, Baselga, José, additional, Tabernero, Josep, additional, Nuciforo, Paolo, additional, Manning, Brendan D., additional, Marjon, Katya, additional, and Carracedo, Arkaitz, additional

Published
2018
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46. PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth

Author

Martín-Martín, Natalia, primary, Zabala-Letona, Amaia, additional, Fernández-Ruiz, Sonia, additional, Arreal, Leire, additional, Camacho, Laura, additional, Castillo-Martin, Mireia, additional, Cortazar, Ana R., additional, Torrano, Verónica, additional, Astobiza, Ianire, additional, Zúñiga-García, Patricia, additional, Ugalde-Olano, Aitziber, additional, Loizaga-Iriarte, Ana, additional, Unda, Miguel, additional, Valcárcel-Jiménez, Lorea, additional, Arruabarrena-Aristorena, Amaia, additional, Piva, Marco, additional, Sánchez-Mosquera, Pilar, additional, Aransay, Ana M., additional, Gomez-Muñoz, Antonio, additional, Barrio, Rosa, additional, Sutherland, James D., additional, and Carracedo, Arkaitz, additional

Published
2018
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47. Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Author

Torrano, Veronica, primary, Valcarcel-Jimenez, Lorea, additional, Cortazar, Ana Rosa, additional, Liu, Xiaojing, additional, Urosevic, Jelena, additional, Castillo-Martin, Mireia, additional, Fernández-Ruiz, Sonia, additional, Morciano, Giampaolo, additional, Caro-Maldonado, Alfredo, additional, Guiu, Marc, additional, Zúñiga-García, Patricia, additional, Graupera, Mariona, additional, Bellmunt, Anna, additional, Pandya, Pahini, additional, Lorente, Mar, additional, Martín-Martín, Natalia, additional, Sutherland, James David, additional, Sanchez-Mosquera, Pilar, additional, Bozal-Basterra, Laura, additional, Zabala-Letona, Amaia, additional, Arruabarrena-Aristorena, Amaia, additional, Berenguer, Antonio, additional, Embade, Nieves, additional, Ugalde-Olano, Aitziber, additional, Lacasa-Viscasillas, Isabel, additional, Loizaga-Iriarte, Ana, additional, Unda-Urzaiz, Miguel, additional, Schultz, Nikolaus, additional, Aransay, Ana Maria, additional, Sanz-Moreno, Victoria, additional, Barrio, Rosa, additional, Velasco, Guillermo, additional, Pinton, Paolo, additional, Cordon-Cardo, Carlos, additional, Locasale, Jason W., additional, Gomis, Roger R., additional, and Carracedo, Arkaitz, additional

Published
2017
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48. Comparative miRNA Analysis of Urine Extracellular Vesicles Isolated through Five Different Methods

Author

Royo, Felix, primary, Diwan, Izzuddin, additional, Tackett, Michael, additional, Zuñiga, Patricia, additional, Sanchez-Mosquera, Pilar, additional, Loizaga-Iriarte, Ana, additional, Ugalde-Olano, Aitziber, additional, Lacasa, Isabel, additional, Perez, Amparo, additional, Unda, Miguel, additional, Carracedo, Arkaitz, additional, and Falcon-Perez, Juan, additional

Published
2016
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50. Hidatidosis pelviana como ejemplo de masas pelvianas de etiología dudosa

Author

Senarriaga Ruiz de la Illa, Nerea, Loizaga Iriarte, Ana, Iriarte Soldevilla, Iñaki, Lacasa Viscasillas, Isabel, and Unda Urzaiz, Miguel

Subjects
Equinococo, Hydatid cyst, Riñón, Quiste hidatídico, Kidney, Echinococcal, Pelvis
Abstract

Presentar dos nuevos casos de quiste hidatídico pelviano, uno con clínica de compresión local y otro asintomático. Varón de 75 años que refiere tenesmo, dificultad para la micción y defecación. Una ecografía revela que se trata de una gran masa quística pelviana que desplaza la vejiga y el rectosigma. La tomografía computarizada describe imágenes compatibles con hidatidosis y un quiste hidatídico hepático. Se interviene quirúrgicamente al paciente, y se extirpa parcialmente el quiste pelviano. El otro caso es un varón de 75 años que, en el estudio de HBP, se descubre de forma casual una hidatidosis pelviana. Se decide, al estar asintomático, vigilancia. La anatomía patológica confirma el diagnóstico en el primer caso y los hallazgos radiológicos, en el segundo. Ambos pacientes están asintomáticos. La posibilidad de hidatidosis se debe considerar en el diagnóstico diferencial de cualquier masa quística localizada en los órganos pelvianos, sobre todo en países donde la enfermedad es endémica. Aunque no hay un test serológico con el 100% de especificidad, las pruebas radiológicas ayudan a confirmar el diagnóstico. La cirugía es el tratamiento de elección. We present two new cases of pelvic hydatid cysts, one with a clinical profile of local compression and the other one asymptomatic. The first case is a 75 year-old man who reported difficulty defecating and urinating. The ultrasound revealed a large cystic pelvic mass displacing the bladder and rectosigmoid region. Computed tomography also showed images compatible with hydatid disease and a hydatid liver cyst. The patient underwent a surgical procedure, and the pelvic cyst was partially excised. The other case is an asymptomatic 75 year-old man with pelvic hydatid disease that was discovered by chance while examining a prostatic adenoma. Because he is asymptomatic, we opted for observation. The anatomical pathology study confirmed the diagnosis in the first case and radiological findings confirmed the second. Both patients remain asymptomatic. Hydatid disease must be considered in the differential diagnosis for any cystic masses in the pelvic organs, especially in countries where the disease is endemic. Although no 100% specific serological test exists, there are some radiological procedures which can help us to confirm the disease. Surgery is the treatment of choice.

Published
2009

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