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723 results on '"Loh M"'

1. Enhanced Risk Stratification for Children and Young Adults with B-Cell Acute Lymphoblastic Leukemia: A Children’s Oncology Group Report

Author

DelRocco, N. J., Loh, M. L., Borowitz, M. J., Gupta, S., Rabin, K. R., Zweidler-McKay, P., Maloney, K. W., Mattano, L. A., Larsen, E., Angiolillo, A., Schore, R. J., Burke, M. J., Salzer, W. L., Wood, B. L., Carroll, A. J., Heerema, N. A., Reshmi, S. C., Gastier-Foster, J. M., Harvey, R., Chen, I. M., Roberts, K. G., Mullighan, C. G., Willman, C., Winick, N., Carroll, W. L., Rau, R. E., Teachey, D. T., Hunger, S. P., Raetz, E. A., Devidas, M., and Kairalla, J. A.

Published
2024
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2. Evidence of 3D Dirac conical bands in TlBiSSe by optical and magneto-optical spectroscopy

Author

Mardelé, F. Le, Wyzula, J., Mohelsky, I., Nasrallah, S., Loh, M., David, S. Ben, Toledano, O., Tolj, D., Novak, M., Eguchi, G., Paschen, S., Barišić, N., Chen, J., Kimura, A., Orlita, M., Rukelj, Z., Akrap, A., and Santos-Cottin, D.

Subjects
Condensed Matter - Materials Science
Abstract

TlBiSSe is a rare realization of a 3D semimetal with a conically dispersing band that has an optical response which is well isolated from other contributions in a broad range of photon eneries. We report optical and magneto-optical spectroscopy on this material. When the compound is chemically tuned into a state of the lowest carrier concentration, we find a nearly linear frequency dependence of the optical conductivity below 0.5~eV. Landau level spectroscopy allows us to describe the system with a massive Dirac model, giving a gap $2\Delta =32$~meV and an in-plane velocity parameter $v= 4.0\times 10^5$~m/s. % Finally, we provide a theoretical recipe to extract all parameters of the anisotropic Dirac band, including the Fermi energy and band degeneracy.

Published
2023
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3. GWTC-3: Compact Binary Coalescences Observed by LIGO and Virgo During the Second Part of the Third Observing Run

Author

The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., Adhikari, N., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akcay, S., Akutsu, T., Albanesi, S., Allocca, A., Altin, P. A., Amato, A., Anand, C., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Andrade, T., Andres, N., Andrić, T., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Appert, S., Arai, Koji, Arai, Koya, Arai, Y., Araki, S., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Arogeti, M., Aronson, S. M., Arun, K. G., Asada, H., Asali, Y., Ashton, G., Aso, Y., Assiduo, M., Aston, S. M., Astone, P., Aubin, F., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Badger, C., Bae, S., Bae, Y., Baer, A. M., Bagnasco, S., Bai, Y., Baiotti, L., Baird, J., Bajpai, R., Ball, M., Ballardin, G., Ballmer, S. W., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Benedetto, V., Beniwal, D., Bennett, T. F., Bentley, J. D., BenYaala, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bhandare, R., Bhardwaj, U., Bhattacharjee, D., Bhaumik, S., Bilenko, I. A., Billingsley, G., Bini, S., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Bogaert, G., Boldrini, M., Bonavena, L. D., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branch, A., Branchesi, M., Brandt, J., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bulik, T., Bulten, H. J., Buonanno, A., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Davies, G. S. Cabourn, Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Cameron, J., Camp, J. B., Canepa, M., Canevarolo, S., Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlin, J. B., Carney, M. F., Carpinelli, M., Carrillo, G., Carullo, G., Carver, T. L., Diaz, J. Casanueva, Casentini, C., Castaldi, G., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Ceasar, M., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakravarti, K., Subrahmanya, S. Chalathadka, Champion, E., Chan, C. -H., Chan, C., Chan, C. L., Chan, K., Chan, M., Chandra, K., Chanial, P., Chao, S., Chapman-Bird, C. E. A., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chatziioannou, K., Chen, C., Chen, H. Y., Chen, J., Chen, K., Chen, X., Chen, Y. -B., Chen, Y. -R., Chen, Z., Cheng, H., Cheong, C. K., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C-Y., Chiarini, G., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Cho, G., Cho, H. S., Choudhary, R. K., Choudhary, S., Christensen, N., Chu, H., Chu, Q., Chu, Y-K., Chua, S., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, E. N., Clark, J. A., Clarke, L., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P. -F., Cohen, D. E., Cohen, L., Colleoni, M., Collette, C. G., Colombo, A., Colpi, M., Compton, C. M., Constancio Jr., M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coulon, J. -P., Countryman, S. T., Cousins, B., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cunningham, L., Cuoco, E., Curyło, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Dálya, G., Dana, A., DaneshgaranBajastani, L. M., D'Angelo, B., Danila, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Datta, S., Dattilo, V., Dave, I., Davier, M., Davis, D., Davis, M. C., Daw, E. J., de Alarcón, P. F., Dean, R., DeBra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Del Pozzo, W., DeMarchi, L. M., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., DeSalvo, R., De Simone, R., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz Jr., M., Didio, N. A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., D'Onofrio, L., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Drago, M., Driggers, J. C., Drori, Y., Ducoin, J. -G., Dupej, P., Durante, O., D'Urso, D., Duverne, P. -A., Dwyer, S. E., Eassa, C., Easter, P. J., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Eguchi, S., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Engelby, E., Enomoto, Y., Errico, L., Essick, R. C., Estellés, H., Estevez, D., Etienne, Z., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fair, H., Fairhurst, S., Farah, A. M., Farinon, S., Farr, B., Farr, W. M., Farrow, N. W., Fauchon-Jones, E. J., Favaro, G., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Floden, E., Fong, H., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Frederick, C., Freed, J. P., Frei, Z., Freise, A., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujii, Y., Fujikawa, Y., Fukunaga, M., Fukushima, M., Fulda, P., Fyffe, M., Gabbard, H. A., Gabella, W. E., Gadre, B. U., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S. G., Garaventa, B., García, F., García-Núñez, C., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Ge, G. -G., Gemme, G., Gennai, A., George, J., George, R. N., Gerberding, O., Gergely, L., Gewecke, P., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Giacomazzo, B., Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giesler, M., Giri, P., Gissi, F., Glanzer, J., Gleckl, A. E., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Golomb, J., Goncharov, B., González, G., Gopakumar, A., Gosselin, M., Gouaty, R., Gould, D. W., Grace, B., Grado, A., Granata, M., Granata, V., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W., Griggs, H. L., Grignani, G., Grimaldi, A., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guerra, D., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, H. -K., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, P., Gustafson, E. K., Gustafson, R., Guzman, F., Ha, S., Haegel, L., Hagiwara, A., Haino, S., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O., Hansen, H., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Hasegawa, K., Haskell, B., Hasskew, R. K., Haster, C. -J., Hattori, K., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F. J., Healy, J., Heidmann, A., Heidt, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Hennig, M. H., Hernandez, A. G., Vivanco, F. Hernandez, Heurs, M., Hild, S., Hill, P., Himemoto, Y., Hines, A. S., Hiranuma, Y., Hirata, N., Hirose, E., Hochheim, S., Hofman, D., Hohmann, J. N., Holcomb, D. G., Holland, N. A., Holley-Bockelmann, K., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hong, Z., Hopkins, P., Hough, J., Hourihane, S., Howell, E. J., Hoy, C. G., Hoyland, D., Hreibi, A., Hsieh, B-H., Hsu, Y., Huang, G-Z., Huang, H-Y., Huang, P., Huang, Y-C., Huang, Y. -J., Huang, Y., Hübner, M. T., Huddart, A. D., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Ide, S., Idzkowski, B., Iess, A., Ikenoue, B., Imam, S., Inayoshi, K., Ingram, C., Inoue, Y., Ioka, K., Isi, M., Isleif, K., Ito, K., Itoh, Y., Iyer, B. R., Izumi, K., JaberianHamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jan, A. Z., Jani, K., Janquart, J., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jenner, K., Jeon, C., Jeunon, M., Jia, W., Jin, H. -B., Johns, G. R., Johnson-McDaniel, N. K., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Jung, P., Jung, K., Junker, J., Juste, V., Kaihotsu, K., Kajita, T., Kakizaki, M., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kao, Y., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaur, T., Kawabe, K., Kawaguchi, K., Kawai, N., Kawasaki, T., Kéfélian, F., Keitel, D., Key, J. S., Khadka, S., Khalili, F. Y., Khan, S., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, J., Kim, K., Kim, W. S., Kim, Y. -M., Kimball, C., Kimura, N., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kita, N., Kitazawa, H., Kleybolte, L., Klimenko, S., Knee, A. M., Knowles, T. D., Knyazev, E., Koch, P., Koekoek, G., Kojima, Y., Kokeyama, K., Koley, S., Kolitsidou, P., Kolstein, M., Komori, K., Kondrashov, V., Kong, A. K. H., Kontos, A., Koper, N., Korobko, M., Kotake, K., Kovalam, M., Kozak, D. B., Kozakai, C., Kozu, R., Kringel, V., Krishnendu, N. V., Królak, A., Kuehn, G., Kuei, F., Kuijer, P., Kulkarni, S., Kumar, A., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuo, C., Kuo, H-S., Kuromiya, Y., Kuroyanagi, S., Kusayanagi, K., Kuwahara, S., Kwak, K., Lagabbe, P., Laghi, D., Lalande, E., Lam, T. L., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y. K., Lee, H. K., Lee, H. M., Lee, H. W., Lee, J., Lee, K., Lee, R., Lehmann, J., Lemaître, A., Leonardi, M., Leroy, N., Letendre, N., Levesque, C., Levin, Y., Leviton, J. N., Leyde, K., Li, A. K. Y., Li, B., Li, J., Li, K. L., Li, T. G. F., Li, X., Lin, C-Y., Lin, F-K., Lin, F-L., Lin, H. L., Lin, L. C. -C., Linde, F., Linker, S. D., Linley, J. N., Littenberg, T. B., Liu, G. C., Liu, J., Liu, K., Liu, X., Llamas, F., Llorens-Monteagudo, M., Lo, R. K. L., Lockwood, A., Loh, M., London, L. T., Longo, A., Lopez, D., Portilla, M. Lopez, Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lott, T. P., Lough, J. D., Lousto, C. O., Lovelace, G., Lucaccioni, J. F., Lück, H., Lumaca, D., Lundgren, A. P., Luo, L. -W., Lynam, J. E., Macas, R., MacInnis, M., Macleod, D. M., MacMillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magazzù, C., Magee, R. M., Maggiore, R., Magnozzi, M., Mahesh, S., Majorana, E., Makarem, C., Maksimovic, I., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mango, J. L., Mansell, G. L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marchio, M., Marion, F., Mark, Z., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, M., Martinez, V. A., Martinez, V., Martinovic, K., Martynov, D. V., Marx, E. J., Masalehdan, H., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Mateu-Lucena, M., Matichard, F., Matiushechkina, M., Mavalvala, N., McCann, J. J., McCarthy, R., McClelland, D. E., McClincy, P. K., McCormick, S., McCuller, L., McGhee, G. I., McGuire, S. C., McIsaac, C., McIver, J., McRae, T., McWilliams, S. T., Meacher, D., Mehmet, M., Mehta, A. K., Meijer, Q., Melatos, A., Melchor, D. A., Mendell, G., Menendez-Vazquez, A., Menoni, C. S., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Milano, L., Miller, A. L., Miller, A., Miller, B., Millhouse, M., Mills, J. C., Milotti, E., Minazzoli, O., Minenkov, Y., Mio, N., Mir, Ll. M., Miravet-Tenés, M., Mishra, C., Mishra, T., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Miyamoto, A., Miyazaki, Y., Miyo, K., Miyoki, S., Mo, Geoffrey, Modafferi, L. M., Moguel, E., Mogushi, K., Mohapatra, S. R. P., Mohite, S. R., Molina, I., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C. J., Moraru, D., Morawski, F., More, A., Moreno, C., Moreno, G., Mori, Y., Morisaki, S., Moriwaki, Y., Morrás, G., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, Soma, Mukherjee, Subroto, Mukherjee, Suvodip, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Musenich, R., Muusse, S., Nadji, S. L., Nagano, K., Nagano, S., Nagar, A., Nakamura, K., Nakano, H., Nakano, M., Nakashima, R., Nakayama, Y., Napolano, V., Nardecchia, I., Narikawa, T., Naticchioni, L., Nayak, B., Nayak, R. K., Negishi, R., Neil, B. F., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neubauer, P., Neunzert, A., Ng, K. Y., Ng, S. W. S., Nguyen, C., Nguyen, P., Nguyen, T., Quynh, L. Nguyen, Ni, W. -T., Nichols, S. A., Nishizawa, A., Nissanke, S., Nitoglia, E., Nocera, F., Norman, M., North, C., Nozaki, S., Siles, J. F. Nuño, Nuttall, L. K., Oberling, J., O'Brien, B. D., Obuchi, Y., O'Dell, J., Oelker, E., Ogaki, W., Oganesyan, G., Oh, J. J., Oh, K., Oh, S. H., Ohashi, M., Ohishi, N., Ohkawa, M., Ohme, F., Ohta, H., Okada, M. A., Okutani, Y., Okutomi, K., Olivetto, C., Oohara, K., Ooi, C., Oram, R., O'Reilly, B., Ormiston, R. G., Ormsby, N. D., Ortega, L. F., O'Shaughnessy, R., O'Shea, E., Oshino, S., Ossokine, S., Osthelder, C., Otabe, S., Ottaway, D. J., Overmier, H., Pace, A. E., Pagano, G., Page, M. A., Pagliaroli, G., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pan, H., Pan, K., Panda, P. K., Pang, H., Pang, P. T. H., Pankow, C., Pannarale, F., Pant, B. C., Panther, F. H., Paoletti, F., Paoli, A., Paolone, A., Parisi, A., Park, H., Park, J., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patel, M., Pathak, M., Patricelli, B., Patron, A. S., Paul, S., Payne, E., Pedraza, M., Pegoraro, M., Pele, A., Arellano, F. E. Peña, Penn, S., Perego, A., Pereira, A., Pereira, T., Perez, C. J., Périgois, C., Perkins, C. C., Perreca, A., Perriès, S., Petermann, J., Petterson, D., Pfeiffer, H. P., Pham, K. A., Phukon, K. S., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierini, L., Pierro, V., Pillant, G., Pillas, M., Pilo, F., Pinard, L., Pinto, I. M., Pinto, M., Piotrzkowski, B., Piotrzkowski, K., Pirello, M., Pitkin, M. 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Subjects
General Relativity and Quantum Cosmology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The third Gravitational-Wave Transient Catalog (GWTC-3) describes signals detected with Advanced LIGO and Advanced Virgo up to the end of their third observing run. Updating the previous GWTC-2.1, we present candidate gravitational waves from compact binary coalescences during the second half of the third observing run (O3b) between 1 November 2019, 15:00 UTC and 27 March 2020, 17:00 UTC. There are 35 compact binary coalescence candidates identified by at least one of our search algorithms with a probability of astrophysical origin $p_\mathrm{astro} > 0.5$. Of these, 18 were previously reported as low-latency public alerts, and 17 are reported here for the first time. Based upon estimates for the component masses, our O3b candidates with $p_\mathrm{astro} > 0.5$ are consistent with gravitational-wave signals from binary black holes or neutron star-black hole binaries, and we identify none from binary neutron stars. However, from the gravitational-wave data alone, we are not able to measure matter effects that distinguish whether the binary components are neutron stars or black holes. The range of inferred component masses is similar to that found with previous catalogs, but the O3b candidates include the first confident observations of neutron star-black hole binaries. Including the 35 candidates from O3b in addition to those from GWTC-2.1, GWTC-3 contains 90 candidates found by our analysis with $p_\mathrm{astro} > 0.5$ across the first three observing runs. These observations of compact binary coalescences present an unprecedented view of the properties of black holes and neutron stars., Comment: 88 pages (10 pages author list, 31 pages main text, 1 page acknowledgements, 24 pages appendices, 22 pages bibliography), 17 figures, 16 tables. Update to match version to be published in Physical Review X. Data products available from https://gwosc.org/GWTC-3/

Published
2021
Full Text
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9. GWTC-3: Compact Binary Coalescences Observed by LIGO and Virgo during the Second Part of the Third Observing Run

Author

Abbott, R, Abbott, T, Acernese, F, Ackley, K, Adams, C, Adhikari, N, Adhikari, R, Adya, V, Affeldt, C, Agarwal, D, Agathos, M, Agatsuma, K, Aggarwal, N, Aguiar, O, Aiello, L, Ain, A, Ajith, P, Akcay, S, Akutsu, T, Albanesi, S, Allocca, A, Altin, P, Amato, A, Anand, C, Anand, S, Ananyeva, A, Anderson, S, Anderson, W, Ando, M, Andrade, T, Andres, N, Andric, T, Angelova, S, Ansoldi, S, Antelis, J, Antier, S, Appert, S, Arai, K, Arai, Y, Araki, S, Araya, A, Araya, M, Areeda, J, Arene, M, Aritomi, N, Arnaud, N, Arogeti, M, Aronson, S, Arun, K, Asada, H, Asali, Y, Ashton, G, Aso, Y, Assiduo, M, Aston, S, Astone, P, Aubin, F, Austin, C, Babak, S, Badaracco, F, Bader, M, Badger, C, Bae, S, Bae, Y, Baer, A, Bagnasco, S, Bai, Y, Baiotti, L, Baird, J, Bajpai, R, Ball, M, Ballardin, G, Ballmer, S, Balsamo, A, Baltus, G, Banagiri, S, Bankar, D, Barayoga, J, Barbieri, C, Barish, B, Barker, D, Barneo, P, Barone, F, Barr, B, Barsotti, L, Barsuglia, M, Barta, D, Bartlett, J, Barton, M, Bartos, I, 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A., Dietrich T., Di Fiore L., Di Fronzo C., Di Giorgio C., Di Giovanni F., Di Giovanni M., Di Girolamo T., Di Lieto A., Ding B., Di Pace S., Di Palma I., Di Renzo F., Divakarla A. K., Dmitriev A., Doctor Z., D'Onofrio L., Donovan F., Dooley K. L., Doravari S., Dorrington I., Drago M., Driggers J. C., Drori Y., Ducoin J. -G., Dupej P., Durante O., D'Urso D., Duverne P. -A., Dwyer S. E., Eassa C., Easter P. J., Ebersold M., Eckhardt T., Eddolls G., Edelman B., Edo T. B., Edy O., Effler A., Eguchi S., Eichholz J., Eikenberry S. S., Eisenmann M., Eisenstein R. A., Ejlli A., Engelby E., Enomoto Y., Errico L., Essick R. C., Estelles H., Estevez D., Etienne Z., Etzel T., Evans M., Evans T. M., Ewing B. E., Fafone V., Fair H., Fairhurst S., Farah A. M., Farinon S., Farr B., Farr W. M., Farrow N. W., Fauchon-Jones E. J., Favaro G., Favata M., Fays M., Fazio M., Feicht J., Fejer M. M., Fenyvesi E., Ferguson D. L., Fernandez-Galiana A., Ferrante I., Ferreira T. A., Fidecaro F., Figura P., Fiori I., Fishbach M., Fisher R. P., Fittipaldi R., Fiumara V., Flaminio R., Floden E., Fong H., Font J. A., Fornal B., Forsyth P. W. F., Franke A., Frasca S., Frasconi F., Frederick C., Freed J. P., Frei Z., Freise A., Frey R., Fritschel P., Frolov V. V., Fronze G. G., Fujii Y., Fujikawa Y., Fukunaga M., Fukushima M., Fulda P., Fyffe M., Gabbard H. A., Gabella W. E., Gadre B. U., Gair J. R., Gais J., Galaudage S., Gamba R., Ganapathy D., Ganguly A., Gao D., Gaonkar S. G., Garaventa B., Garcia F., Garcia-Nunez C., Garcia-Quiros C., Garufi F., Gateley B., Gaudio S., Gayathri V., Ge G. -G., Gemme G., Gennai A., George J., George R. N., Gerberding O., Gergely L., Gewecke P., Ghonge S., Ghosh A., Ghosh S., Giacomazzo B., Giacoppo L., Giaime J. A., Giardina K. D., Gibson D. R., Gier C., Giesler M., Giri P., Gissi F., Glanzer J., Gleckl A. 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N., Nuttall L. K., Oberling J., O'Brien B. D., Obuchi Y., O'Dell J., Oelker E., Ogaki W., Oganesyan G., Oh J. J., Oh K., Oh S. H., Ohashi M., Ohishi N., Ohkawa M., Ohme F., Ohta H., Okada M. A., Okutani Y., Okutomi K., Olivetto C., Oohara K., Ooi C., Oram R., O'Reilly B., Ormiston R. G., Ormsby N. D., Ortega L. F., O'Shaughnessy R., O'Shea E., Oshino S., Ossokine S., Osthelder C., Otabe S., Ottaway D. J., Overmier H., Pace A. E., Pagano G., Page M. A., Pagliaroli G., Pai A., Pai S. A., Palamos J. R., Palashov O., Palomba C., Pan H., Pan K., Panda P. K., Pang H., Pang P. T. H., Pankow C., Pannarale F., Pant B. C., Panther F. H., Paoletti F., Paoli A., Paolone A., Parisi A., Park H., Park J., Parker W., Pascucci D., Pasqualetti A., Passaquieti R., Passuello D., Patel M., Pathak M., Patricelli B., Patron A. S., Paul S., Payne E., Pedraza M., Pegoraro M., Pele A., Arellano F. E. P., Penn S., Perego A., Pereira A., Pereira T., Perez C. J., Perigois C., Perkins C. C., Perreca A., Perries S., Petermann J., Petterson D., Pfeiffer H. P., Pham K. A., Phukon K. S., Piccinni O. J., Pichot M., Piendibene M., Piergiovanni F., Pierini L., Pierro V., Pillant G., Pillas M., Pilo F., Pinard L., Pinto I. M., Pinto M., Piotrzkowski B., Piotrzkowski K., Pirello M., Pitkin M. D., Placidi E., Planas L., Plastino W., Pluchar C., Poggiani R., Polini E., Pong D. Y. T., Ponrathnam S., Popolizio P., Porter E. K., Poulton R., Powell J., Pracchia M., Pradier T., Prajapati A. K., Prasai K., Prasanna R., Pratten G., Principe M., Prodi G. A., Prokhorov L., Prosposito P., Prudenzi L., Puecher A., Punturo M., Puosi F., Puppo P., Purrer M., Qi H., Quetschke V., Quitzow-James R., Qutob N., Raab F. J., Raaijmakers G., Radkins H., Radulesco N., Raffai P., Rail S. X., Raja S., Rajan C., Ramirez K. E., Ramirez T. D., Ramos-Buades A., Rana J., Rapagnani P., Rapol U. D., Ray A., Raymond V., Raza N., Razzano M., Read J., Rees L. A., Regimbau T., Rei L., Reid S., Reid S. W., Reitze D. H., Relton P., Renzini A., Rettegno P., Reza A., Rezac M., Ricci F., Richards D., Richardson J. W., Richardson L., Riemenschneider G., Riles K., Rinaldi S., Rink K., Rizzo M., Robertson N. A., Robie R., Robinet F., Rocchi A., Rodriguez S., Rolland L., Rollins J. G., Romanelli M., Romano R., Romel C. L., Romero-Rodriguez A., Romero-Shaw I. M., Romie J. H., Ronchini S., Rosa L., Rose C. A., Rosinska D., Ross M. P., Rowan S., Rowlinson S. J., Roy S., Rozza D., Ruggi P., Ruiz-Rocha K., Ryan K., Sachdev S., Sadecki T., Sadiq J., Sago N., Saito S., Saito Y., Sakai K., Sakai Y., Sakellariadou M., Sakuno Y., Salafia O. S., Salconi L., Saleem M., Salemi F., Samajdar A., Sanchez E. J., Sanchez J. H., Sanchez L. E., Sanchis-Gual N., Sanders J. R., Sanuy A., Saravanan T. R., Sarin N., Sassolas B., Satari H., Sathyaprakash B. S., Sato S., Sato T., Sauter O., Savage R. L., Sawada T., Sawant D., Sawant H. L., Sayah S., Schaetzl D., Scheel M., Scheuer J., Schiworski M., Schmidt P., Schmidt S., Schnabel R., Schneewind M., Schofield R. M. S., Schonbeck A., Schulte B. W., Schutz B. F., Schwartz E., Scott J., Scott S. M., Seglar-Arroyo M., Sekiguchi T., Sekiguchi Y., Sellers D., Sengupta A. S., Sentenac D., Seo E. G., Sequino V., Sergeev A., Setyawati Y., Shaffer T., Shahriar M. S., Shams B., Shao L., Sharma A., Sharma P., Shawhan P., Shcheblanov N. S., Shibagaki S., Shikauchi M., Shimizu R., Shimoda T., Shimode K., Shinkai H., Shishido T., Shoda A., Shoemaker D. H., Shoemaker D. M., Shyamsundar S., Sieniawska M., Sigg D., Singer L. P., Singh D., Singh N., Singha A., Sintes A. M., Sipala V., Skliris V., Slagmolen B. J. J., Slaven-Blair T. J., Smetana J., Smith J. R., Smith R. J. E., Soldateschi J., Somala S. N., Somiya K., Son E. J., Soni K., Soni S., Sordini V., Sorrentino F., Sorrentino N., Sotani H., Soulard R., Souradeep T., Sowell E., Spagnuolo V., Spencer A. P., Spera M., Srinivasan R., Srivastava A. K., Srivastava V., Staats K., Stachie C., Steer D. A., Steinhoff J., Steinlechner J., Steinlechner S., Stevenson S. P., Stops D. J., Stover M., Strain K. A., Strang L. C., Stratta G., Strunk A., Sturani R., Stuver A. L., Sudhagar S., Sudhir V., Sugimoto R., Suh H. G., Sullivan A. G., Sullivan J. M., Summerscales T. Z., Sun H., Sun L., Sunil S., Sur A., Suresh J., Sutton P. J., Suzuki T., Swinkels B. L., Szczepanczyk M. J., Szewczyk P., Tacca M., Tagoshi H., Tait S. C., Takahashi H., Takahashi R., Takamori A., Takano S., Takeda H., Takeda M., Talbot C. J., Talbot C., Tanaka H., Tanaka K., Tanaka T., Tanasijczuk A. J., Tanioka S., Tanner D. B., Tao D., Tao L., Martin E. N. T. S., Taranto C., Tasson J. D., Telada S., Tenorio R., Terhune J. E., Terkowski L., Thirugnanasambandam M. P., Thomas L., Thomas M., Thomas P., Thompson J. E., Thondapu S. R., Thorne K. A., Thrane E., Tiwari S., Tiwari V., Toivonen A. M., Toland K., Tolley A. E., Tomaru T., Tomigami Y., Tomura T., Tonelli M., Torres-Forne A., Torrie C. I., E Melo I. T., Toyra D., Trapananti A., Travasso F., Traylor G., Trevor M., Tringali M. C., Tripathee A., Troiano L., Trovato A., Trozzo L., Trudeau R. J., Tsai D. S., Tsai D., Tsang K. W., Tsang T., Tsao J. -S., Tse M., Tso R., Tsubono K., Tsuchida S., Tsukada L., Tsuna D., Tsutsui T., Tsuzuki T., Turbang K., Turconi M., Tuyenbayev D., Ubhi A. S., Uchikata N., Uchiyama T., Udall R. P., Ueda A., Uehara T., Ueno K., Ueshima G., Unnikrishnan C. S., Uraguchi F., Urban A. L., Ushiba T., Utina A., Vahlbruch H., Vajente G., Vajpeyi A., Valdes G., Valentini M., Valsan V., Van Bakel N., Van Beuzekom M., Van Den Brand J. F. J., Van Den Broeck C., Vander-Hyde D. C., Van Der Schaaf L., Van Heijningen J. V., Vanosky J., Van Putten M. H. P. M., Van Remortel N., Vardaro M., Vargas A. F., Varma V., Vasuth M., Vecchio A., Vedovato G., Veitch J., Veitch P. J., Venneberg J., Venugopalan G., Verkindt D., Verma P., Verma Y., Veske D., Vetrano F., Vicere A., Vidyant S., Viets A. D., Vijaykumar A., Villa-Ortega V., Vinet J. -Y., Virtuoso A., Vitale S., Vo T., Vocca H., Von Reis E. R. G., Von Wrangel J. S. A., Vorvick C., Vyatchanin S. P., Wade L. E., Wade M., Wagner K. J., Walet R. C., Walker M., Wallace G. S., Wallace L., Walsh S., Wang J., Wang J. Z., Wang W. H., Ward R. L., Warner J., Was M., Washimi T., Washington N. Y., Watchi J., Weaver B., Webster S. A., Weinert M., Weinstein A. J., Weiss R., Weller C. M., Weller R. A., Wellmann F., Wen L., Wessels P., Wette K., Whelan J. T., White D. D., Whiting B. F., Whittle C., Wilken D., Williams D., Williams M. J., Williams N., Williamson A. R., Willis J. L., Willke B., Wilson D. J., Winkler W., Wipf C. C., Wlodarczyk T., Woan G., Woehler J., Wofford J. K., Wong I. C. F., Wu C., Wu D. S., Wu H., Wu S., Wysocki D. M., Xiao L., Xu W. -R., Yamada T., Yamamoto H., Yamamoto K., Yamamoto T., Yamashita K., Yamazaki R., Yang F. W., Yang L., Yang Y., Yang Z., Yap M. J., Yeeles D. W., Yelikar A. B., Ying M., Yokogawa K., Yokoyama J., Yokozawa T., Yoo J., Yoshioka T., Yu H., Yuzurihara H., Zadrozny A., Zanolin M., Zeidler S., Zelenova T., Zendri J. -P., Zevin M., Zhan M., Zhang H., Zhang J., Zhang L., Zhang T., Zhang Y., Zhao C., Zhao G., Zhao Y., Zheng Y., Zhou R., Zhou Z., Zhu X. J., Zhu Z. -H., Zimmerman A. B., Zlochower Y., Zucker M. E., and Zweizig J.

Abstract

The third Gravitational-Wave Transient Catalog (GWTC-3) describes signals detected with Advanced LIGO and Advanced Virgo up to the end of their third observing run. Updating the previous GWTC-2.1, we present candidate gravitational waves from compact binary coalescences during the second half of the third observing run (O3b) between 1 November 2019, 15∶00 Coordinated Universal Time (UTC) and 27 March 2020, 17∶00 UTC. There are 35 compact binary coalescence candidates identified by at least one of our search algorithms with a probability of astrophysical origin pastro>0.5. Of these, 18 were previously reported as low-latency public alerts, and 17 are reported here for the first time. Based upon estimates for the component masses, our O3b candidates with pastro>0.5 are consistent with gravitational-wave signals from binary black holes or neutron-star-black-hole binaries, and we identify none from binary neutron stars. However, from the gravitational-wave data alone, we are not able to measure matter effects that distinguish whether the binary components are neutron stars or black holes. The range of inferred component masses is similar to that found with previous catalogs, but the O3b candidates include the first confident observations of neutron-star-black-hole binaries. Including the 35 candidates from O3b in addition to those from GWTC-2.1, GWTC-3 contains 90 candidates found by our analysis with pastro>0.5 across the first three observing runs. These observations of compact binary coalescences present an unprecedented view of the properties of black holes and neutron stars.

Published
2023

10. Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial

Author

Hunger, S, Tran, T, Saha, V, Devidas, M, Valsecchi, M, Gastier-Foster, J, Cazzaniga, G, Reshmi, S, Borowitz, M, Moorman, A, Heerema, N, Carroll, A, Martin-Regueira, P, Loh, M, Raetz, E, Schultz, K, Slayton, W, Cario, G, Schrappe, M, Silverman, L, Biondi, A, Hunger S. P., Tran T. H., Saha V., Devidas M., Valsecchi M. G., Gastier-Foster J. M., Cazzaniga G., Reshmi S. C., Borowitz M. J., Moorman A. V., Heerema N. A., Carroll A. J., Martin-Regueira P., Loh M. L., Raetz E. A., Schultz K. R., Slayton W. B., Cario G., Schrappe M., Silverman L. B., Biondi A., Hunger, S, Tran, T, Saha, V, Devidas, M, Valsecchi, M, Gastier-Foster, J, Cazzaniga, G, Reshmi, S, Borowitz, M, Moorman, A, Heerema, N, Carroll, A, Martin-Regueira, P, Loh, M, Raetz, E, Schultz, K, Slayton, W, Cario, G, Schrappe, M, Silverman, L, Biondi, A, Hunger S. P., Tran T. H., Saha V., Devidas M., Valsecchi M. G., Gastier-Foster J. M., Cazzaniga G., Reshmi S. C., Borowitz M. J., Moorman A. V., Heerema N. A., Carroll A. J., Martin-Regueira P., Loh M. L., Raetz E. A., Schultz K. R., Slayton W. B., Cario G., Schrappe M., Silverman L. B., and Biondi A.

Abstract

Background: The outcome of children with Philadelphia chromosome-positive (Ph-positive) acute lymphoblastic leukaemia significantly improved with the combination of imatinib and intensive chemotherapy. We aimed to investigate the efficacy of dasatinib, a second-generation ABL-class inhibitor, with intensive chemotherapy in children with newly diagnosed Ph-positive acute lymphoblastic leukaemia. Methods: CA180-372/COG AALL1122 was a joint Children's Oncology Group (COG) and European intergroup study of post-induction treatment of Ph-positive acute lymphoblastic leukaemia (EsPhALL) open-label, single-arm, phase 2 study. Eligible patients (aged >1 year to <18 years) with newly diagnosed Ph-positive acute lymphoblastic leukaemia and performance status of at least 60% received EsPhALL chemotherapy plus dasatinib 60 mg/m2 orally once daily from day 15 of induction. Patients with minimal residual disease of at least 0·05% after induction 1B or who were positive for minimal residual disease after the three consolidation blocks were classified as high risk and allocated to receive haematopoietic stem-cell transplantation (HSCT) in first complete remission. The remaining patients were considered standard risk and received chemotherapy plus dasatinib for 2 years. The primary endpoint was the 3-year event-free survival of dasatinib plus chemotherapy compared with external historical controls. The trial was considered positive if one of the following conditions was met: superiority over chemotherapy alone in the AIEOP-BFM 2000 high-risk group; or non-inferiority (with a margin of –5%) or superiority to imatinib plus chemotherapy in the EsPhALL 2010 cohort. All participants who received at least one dose of dasatinib were included in the safety and efficacy analyses. This trial was registered with ClinicalTrials.gov, NCT01460160, and recruitment is closed. Findings: Between March 13, 2012, and May 27, 2014, 109 patients were enrolled at 69 sites (including 51 COG sites in t

Published
2023

14. LB1740 Role of host epigenetics with skin microbiome in atopic dermatitis

Author

Yew, Y., primary, Tay, D., additional, Lim, S., additional, Wearne, S.J., additional, Mina, T., additional, Riboli, E., additional, Lee, E., additional, Lee, J., additional, Ngeow, J., additional, Elliott, P., additional, Thng, S.T., additional, Common, J.E., additional, Chambers, J., additional, and Loh, M., additional

Published
2023
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15. Application of a Self-Similar Pressure Profile to Sunyaev-Zel'dovich Effect Data from Galaxy Clusters

Author

Mroczkowski, T., Bonamente, M., Carlstrom, J. E., Culverhouse, T. L., Greer, C., Hawkins, D., Hennessy, R., Joy, M., Lamb, J. W., Leitch, E. M., Loh, M., Maughan, B., Marrone, D. P., Miller, A., Nagai, D., Muchovej, S., Pryke, C., Sharp, M., and Woody, D.

Subjects
Astrophysics
Abstract

We investigate the utility of a new, self-similar pressure profile for fitting Sunyaev-Zel'dovich (SZ) effect observations of galaxy clusters. Current SZ imaging instruments - such as the Sunyaev-Zel'dovich Array (SZA) - are capable of probing clusters over a large range in physical scale. A model is therefore required that can accurately describe a cluster's pressure profile over a broad range of radii, from the core of the cluster out to a significant fraction of the virial radius. In the analysis presented here, we fit a radial pressure profile derived from simulations and detailed X-ray analysis of relaxed clusters to SZA observations of three clusters with exceptionally high quality X-ray data: A1835, A1914, and CL J1226.9+3332. From the joint analysis of the SZ and X-ray data, we derive physical properties such as gas mass, total mass, gas fraction and the intrinsic, integrated Compton y-parameter. We find that parameters derived from the joint fit to the SZ and X-ray data agree well with a detailed, independent X-ray-only analysis of the same clusters. In particular, we find that, when combined with X-ray imaging data, this new pressure profile yields an independent electron radial temperature profile that is in good agreement with spectroscopic X-ray measurements., Comment: 28 pages, 6 figures, accepted by ApJ for publication (probably April 2009)

Published
2008
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17. Evidence for three-dimensional Dirac conical bands in TlBiSSe by optical and magneto-optical spectroscopy

Author

Le Mardelé, F., primary, Wyzula, J., additional, Mohelsky, I., additional, Nasrallah, S., additional, Loh, M., additional, Ben David, S., additional, Toledano, O., additional, Tolj, D., additional, Novak, M., additional, Eguchi, G., additional, Paschen, S., additional, Barišić, N., additional, Chen, J., additional, Kimura, A., additional, Orlita, M., additional, Rukelj, Z., additional, Akrap, Ana, additional, and Santos-Cottin, D., additional

Published
2023
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20. Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium

Author

Buchmann, S, Schrappe, M, Baruchel, A, Biondi, A, Borowitz, M, Campbell, M, Cario, G, Cazzaniga, G, Escherich, G, Harrison, C, Heyman, M, Hunger, S, Kiss, C, Liu, H, Locatelli, F, Loh, M, Manabe, A, Mann, G, Pieters, R, Pui, C, Rives, S, Schmiegelow, K, Silverman, L, Stary, J, Vora, A, Brown, P, Buchmann S., Schrappe M., Baruchel A., Biondi A., Borowitz M., Campbell M., Cario G., Cazzaniga G., Escherich G., Harrison C. J., Heyman M., Hunger S. P., Kiss C., Liu H. -C., Locatelli F., Loh M. L., Manabe A., Mann G., Pieters R., Pui C. -H., Rives S., Schmiegelow K., Silverman L. B., Stary J., Vora A., Brown P., Buchmann, S, Schrappe, M, Baruchel, A, Biondi, A, Borowitz, M, Campbell, M, Cario, G, Cazzaniga, G, Escherich, G, Harrison, C, Heyman, M, Hunger, S, Kiss, C, Liu, H, Locatelli, F, Loh, M, Manabe, A, Mann, G, Pieters, R, Pui, C, Rives, S, Schmiegelow, K, Silverman, L, Stary, J, Vora, A, Brown, P, Buchmann S., Schrappe M., Baruchel A., Biondi A., Borowitz M., Campbell M., Cario G., Cazzaniga G., Escherich G., Harrison C. J., Heyman M., Hunger S. P., Kiss C., Liu H. -C., Locatelli F., Loh M. L., Manabe A., Mann G., Pieters R., Pui C. -H., Rives S., Schmiegelow K., Silverman L. B., Stary J., Vora A., and Brown P.

Abstract

Comparison of treatment strategies in de novo pediatric acute lymphoblastic leukemia (ALL) requires standardized measures of efficacy. Key parameters that define disease-related events, including complete remission (CR), treatment failure (TF; not achieving CR), and relapse (loss of CR) require an updated consensus incorporating modern diagnostics. We collected the definitions of CR, TF, and relapse from recent and current pediatric clinical trials for the treatment of ALL, including the key components of response evaluation (timing, anatomic sites, detection methods, and thresholds) and found significant heterogeneity, most notably in the definition of TF. Representatives of the major international ALL clinical trial groups convened to establish consensus definitions. CR should be defined at a time point no earlier than at the end of induction and should include the reduction of blasts below a specific threshold in bone marrow and extramedullary sites, incorporating minimal residual disease (MRD) techniques for marrow evaluations. TF should be defined as failure to achieve CR by a prespecified time point in therapy. Relapse can only be defined in patients who have achieved CR and must include a specific threshold of leukemic cells in the bone marrow confirmed by MRD, the detection of central nervous system leukemia, or documentation of extramedullary disease. Definitions of TF and relapse should harmonize with eligibility criteria for clinical trials in relapsed/refractory ALL. These consensus definitions will enhance the ability to compare outcomes across pediatric ALL trials and facilitate development of future international collaborative trials.

Published
2022

21. ALL-049 A Phase 1/2 Study to Evaluate Ponatinib With Chemotherapy in Pediatric Patients With Relapsed/Resistant/Intolerant Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia or With T315I Mutation

Author

Gore, L, Loh, M, Pui, C, Matloub, Y, Hanley, M, Du, J, Hennessy, M, Granier, M, Biondi, A, Silverman, L, Gore L., Loh M., Pui C. -H., Matloub Y., Hanley M. J., Du J., Hennessy M., Granier M., Biondi A., Silverman L., Gore, L, Loh, M, Pui, C, Matloub, Y, Hanley, M, Du, J, Hennessy, M, Granier, M, Biondi, A, Silverman, L, Gore L., Loh M., Pui C. -H., Matloub Y., Hanley M. J., Du J., Hennessy M., Granier M., Biondi A., and Silverman L.

Abstract

Objectives: Ponatinib, a potent third-generation tyrosine kinase inhibitor (TKI), is approved for adults with chronic/accelerated/blast-phase chronic myeloid leukemia or Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) whose disease is resistant/intolerant to other TKIs or has the T315I mutation. This study in pediatric patients with relapsed/resistant/intolerant Ph+ ALL or those with the T315I mutation aims to establish the recommended Phase 2 dose (RP2D) of ponatinib and assess the pharmacokinetics, safety, and efficacy of ponatinib in combination with chemotherapy. Methods: This Phase 1/2, single-arm, open-label, multicenter study is enrolling patients age ≥1–21 years with Ph+ ALL, Ph+ mixed-phenotype acute leukemia, or Ph-like ALL (United States only) who have a targetable kinase-activating lesion and whose disease has relapsed or is resistant/intolerant to ≥1 prior therapy with a second-generation BCR::ABL1–targeted TKI or has a BCR::ABL1 T315I mutation. Phase 1 uses a rolling 6 design; the first cohort will include up to 12 patients (≥30 kg and able to swallow tablets) for dose confirmation. Another cohort of 6 patients will be enrolled to assess the age-appropriate mini-tablet formulation at the RP2D. Phase 2 will enroll ≈68 patients, including those enrolled in Phase 1 at the RP2D. Patients must have an age-appropriate (Lansky or Karnofsky) Performance Scale score of ≥50%. In Phase 1, the primary endpoint is the RP2D of ponatinib in combination with chemotherapy. Secondary endpoints are complete response (CR) rate at the end of the reinduction block and characterization of BCR::ABL1 domain mutations before and after ponatinib treatment. In Phase 2, the primary endpoint is the CR rate at the end of the reinduction block. Secondary endpoints include the proportion of patients in continued CR or who achieve CR at the end of consolidation, event-free survival (EFS), progression-free survival, and overall survival. Conclusions: The study

Published
2022

22. Molecular characterisation and clinical outcome of B-cell precursor acute lymphoblastic leukaemia with IG-MYC rearrangement

Author

Bomken, S, Enshaei, A, Schwalbe, E, Mikulasova, A, Dai, Y, Zaka, M, Fung, K, Bashton, M, Lim, H, Jones, L, Karataraki, N, Winterman, E, Ashby, C, Attarbaschi, A, Bertrand, Y, Bradtke, J, Buldini, B, Burke, G, Cazzaniga, G, Gohring, G, De Groot-Kruseman, H, Haferlach, C, Nigro, L, Parihar, M, Plesa, A, Seaford, E, Sonneveld, E, Strehl, S, Van der Velden, V, Rand, V, Hunger, S, Harrison, C, Bacon, C, Van Delft, F, Loh, M, Moppett, J, Vormoor, J, Walker, B, Moorman, A, Russell, L, Bomken, Simon, Enshaei, Amir, Schwalbe, Edward C, Mikulasova, Aneta, Dai, Yunfeng, Zaka, Masood, Fung, Kent Tm, Bashton, Matthew, Lim, Huezin, Jones, Lisa, Karataraki, Nefeli, Winterman, Emily, Ashby, Cody, Attarbaschi, Andishe, Bertrand, Yves, Bradtke, Jutta, Buldini, Barbara, Burke, G. A. Amos, Cazzaniga, Giovanni, Gohring, Gudrun, De Groot-Kruseman, Hesta A, Haferlach, Claudia, Nigro, Luca Lo, Parihar, Mayur, Plesa, Adriana, Seaford, Emma, Sonneveld, Edwin, Strehl, Sabine, Van der Velden, Vincent Hj, Rand, Vikki, Hunger, Stephen P, Harrison, Christine J, Bacon, Chris M, Van Delft, Frederik W, Loh, Mignon L, Moppett, John, Vormoor, Josef, Walker, Brian A, Moorman, Anthony V, Russell, Lisa J, Bomken, S, Enshaei, A, Schwalbe, E, Mikulasova, A, Dai, Y, Zaka, M, Fung, K, Bashton, M, Lim, H, Jones, L, Karataraki, N, Winterman, E, Ashby, C, Attarbaschi, A, Bertrand, Y, Bradtke, J, Buldini, B, Burke, G, Cazzaniga, G, Gohring, G, De Groot-Kruseman, H, Haferlach, C, Nigro, L, Parihar, M, Plesa, A, Seaford, E, Sonneveld, E, Strehl, S, Van der Velden, V, Rand, V, Hunger, S, Harrison, C, Bacon, C, Van Delft, F, Loh, M, Moppett, J, Vormoor, J, Walker, B, Moorman, A, Russell, L, Bomken, Simon, Enshaei, Amir, Schwalbe, Edward C, Mikulasova, Aneta, Dai, Yunfeng, Zaka, Masood, Fung, Kent Tm, Bashton, Matthew, Lim, Huezin, Jones, Lisa, Karataraki, Nefeli, Winterman, Emily, Ashby, Cody, Attarbaschi, Andishe, Bertrand, Yves, Bradtke, Jutta, Buldini, Barbara, Burke, G. A. Amos, Cazzaniga, Giovanni, Gohring, Gudrun, De Groot-Kruseman, Hesta A, Haferlach, Claudia, Nigro, Luca Lo, Parihar, Mayur, Plesa, Adriana, Seaford, Emma, Sonneveld, Edwin, Strehl, Sabine, Van der Velden, Vincent Hj, Rand, Vikki, Hunger, Stephen P, Harrison, Christine J, Bacon, Chris M, Van Delft, Frederik W, Loh, Mignon L, Moppett, John, Vormoor, Josef, Walker, Brian A, Moorman, Anthony V, and Russell, Lisa J

Abstract

Rarely, immunophenotypically immature B-cell precursor acute lymphoblastic leukemia (BCP-ALL) carries an immunoglobulin-MYC rearrangement (IG-MYC-r). This can result in diagnostic confusion with Burkitt lymphoma/leukemia and use of individualized treatment schedules of unproven efficacy. Here we compare the molecular characteristics of these conditions and investigate historic clinical outcome data. We identified 90 cases registered in a national BCP-ALL clinical trial/registry. When present, diagnostic material underwent cytogenetic, exome, methylome and transcriptome analyses. The outcomes analyzed were 3-year event-free survival and overall survival. IG-MYC-r was identified in diverse cytogenetic backgrounds, co-existing with either established BCP-ALL-specific abnormalities (high hyperdiploidy, n=3; KMT2A-rearrangement, n=6; iAMP21, n=1; BCR-ABL1, n=1); BCL2/BCL6-rearrangements (n=15); or, most commonly, as the only defining feature (n=64). Within this final group, precursor-like V(D)J breakpoints predominated (8/9) and KRAS mutations were common (5/11). DNA methylation identified a cluster of V(D)J-rearranged cases, clearly distinct from Burkitt leukemia/lymphoma. Children with IG-MYC-r within that subgroup had a 3-year event-free survival of 47% and overall survival of 60%, representing a high-risk BCP-ALL. To develop effective management strategies this group of patients must be allowed access to contemporary, minimal residual disease-adapted, prospective clinical trial protocols.

Published
2023

23. Population of Merging Compact Binaries Inferred Using Gravitational Waves through GWTC-3

Author

Abbott, R., Abbott, T.D., Acernese, F., Ackley, K., Adams, C., Adhikari, N., Adhikari, R.X., Adya, V.B., Affeldt, C., Agarwal, D., Agathos, M., Bejger, M., Mohite, S.R., Molina, I., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C.J., Moraru, D., Morawski, F., More, A., Moreno, C., Belahcene, I., Moreno, G., Mori, Y., Morisaki, S., Moriwaki, Y., Morrás, G., Mours, B., Mow-Lowry, C.M., Mozzon, S., Muciaccia, F., Mukherjee, A., Benedetto, V., Mukherjee, D., Mukherjee, S., Mukund, N., Mullavey, A., Munch, J., Muñiz, E.A., Murray, P.G., Musenich, R., Muusse, S., Nadji, S.L., Beniwal, D., Nagano, K., Nagano, S., Nagar, A., Nakamura, K., Nakano, H., Nakano, M., Nakashima, R., Nakayama, Y., Napolano, V., Nardecchia, I., Bennett, T.F., Narikawa, T., Naticchioni, L., Nayak, B., Nayak, R.K., Negishi, R., Neil, B.F., Neilson, J., Nelemans, G., Nelson, T.J.N., Nery, M., Bentley, J.D., Neubauer, P., Neunzert, A., Ng, K.Y., Ng, S.W.S., Nguyen, C., Nguyen, P., Nguyen, T., Quynh, L.N., Ni, W.-T., Nichols, S.A., Benyaala, M., Nishizawa, A., Nissanke, S., Nitoglia, E., Nocera, F., Norman, M., North, C., Nozaki, S., Siles, J.F.N., Nuttall, L.K., Oberling, J., Bergamin, F., O'Brien, B.D., Obuchi, Y., O'Dell, J., Oelker, E., Ogaki, W., Oganesyan, G., Oh, J.J., Oh, K., Oh, S.H., Ohashi, M., Berger, B.K., Ohishi, N., Ohkawa, M., Ohme, F., Ohta, H., Okada, M.A., Okutani, Y., Okutomi, K., Olivetto, C., Oohara, K., Ooi, C., Bernuzzi, S., Oram, R., O'Reilly, B., Ormiston, R.G., Ormsby, N.D., Ortega, L.F., O'Shaughnessy, R., O'Shea, E., Oshino, S., Ossokine, S., Osthelder, C., Agatsuma, K., Berry, C.P.L., Otabe, S., Ottaway, D.J., Overmier, H., Pace, A.E., Pagano, G., Page, M.A., Pagliaroli, G., Pai, A., Pai, S.A., Palamos, J.R., Bersanetti, D., Palashov, O., Palomba, C., Pan, H., Pan, K., Panda, P.K., Pang, H., Pang, P.T.H., Pankow, C., Pannarale, F., Pant, B.C., Bertolini, A., Panther, F.H., Paoletti, F., Paoli, A., Paolone, A., Parisi, A., Park, H., Park, J., Parker, W., Pascucci, D., Pasqualetti, A., Betzwieser, J., Passaquieti, R., Passuello, D., Patel, M., Pathak, M., Patricelli, B., Patron, A.S., Lavery, Paul S., Payne, E., Pedraza, M., Pegoraro, M., Beveridge, D., Pele, A., Arellano, F.E.P., Penn, S., Perego, A., Pereira, A., Pereira, T., Perez, C.J., Périgois, C., Perkins, C.C., Perreca, A., Bhandare, R., Perriès, S., Petermann, J., Petterson, D., Pfeiffer, H.P., Pham, K.A., Phukon, K.S., Piccinni, O.J., Pichot, M., Piendibene, M., Piergiovanni, F., Bhardwaj, U., Pierini, L., Pierro, V., Pillant, G., Pillas, M., Pilo, F., Pinard, L., Pinto, I.M., Pinto, M., Piotrzkowski, B., Piotrzkowski, K., Bhattacharjee, D., Pirello, M., Pitkin, M.D., Placidi, E., Planas, L., Plastino, W., Pluchar, C., Poggiani, R., Polini, E., Pong, D.Y.T., Ponrathnam, S., Bhaumik, S., Popolizio, P., Porter, E.K., Poulton, R., Powell, J., Pracchia, M., Pradier, T., Prajapati, A.K., Prasai, K., Prasanna, R., Pratten, G., Bilenko, I.A., Principe, M., Prodi, G.A., Prokhorov, L., Prosposito, P., Prudenzi, L., Puecher, A., Punturo, M., Puosi, F., Puppo, P., Pürrer, M., Aggarwal, N., Billingsley, G., Qi, H., Quetschke, V., Quitzow-James, R., Raab, F.J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rail, S.X., Raja, S., Bini, S., Rajan, C., Ramirez, K.E., Ramirez, T.D., Ramos-Buades, A., Rana, J., Rapagnani, P., Rapol, U.D., Ray, A., Raymond, V., Raza, N., Birney, R., Razzano, M., Read, J., Rees, L.A., Regimbau, T., Rei, L., Reid, S., Reid, S.W., Reitze, D.H., Relton, P., Renzini, A., Birnholtz, O., Rettegno, P., Reza, A., Rezac, M., Ricci, F., Richards, D., Richardson, J.W., Richardson, L., Riemenschneider, G., Riles, K., Rinaldi, S., Biscans, S., Rink, K., Rizzo, M., Robertson, N.A., Robie, R., Robinet, F., Rocchi, A., Rodriguez, S., Rolland, L., Rollins, J.G., Romanelli, M., Bischi, M., Romano, R., Romel, C.L., Romero-Rodríguez, A., Romero-Shaw, I.M., Romie, J.H., Ronchini, S., Rosa, L., Rose, C.A., Rosińska, D., Ross, M.P., Biscoveanu, S., Rowan, S., Rowlinson, S.J., Roy, S., Rozza, D., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadiq, J., Sago, N., Bisht, A., Saito, S., Saito, Y., Sakai, K., Sakai, Y., Sakellariadou, M., Sakuno, Y., Salafia, O.S., Salconi, L., Saleem, M., Salemi, F., Biswas, B., Samajdar, A., Sanchez, E.J., Sanchez, J.H., Sanchez, L.E., Sanchis-Gual, N., Sanders, J.R., Sanuy, A., Saravanan, T.R., Sarin, N., Sassolas, B., Bitossi, M., Satari, H., Sathyaprakash, B.S., Sato, S., Sato, T., Sauter, O., Savage, R.L., Sawada, T., Sawant, D., Sawant, H.L., Sayah, S., Aguiar, O.D., Bizouard, M.-A., Schaetzl, D., Scheel, M., Scheuer, J., Schiworski, M., Schmidt, P., Schmidt, S., Schnabel, R., Schneewind, M., Schofield, R.M.S., Schönbeck, A., Blackburn, J.K., Schulte, B.W., Schutz, B.F., Schwartz, E., Scott, J., Scott, S.M., Seglar-Arroyo, M., Sekiguchi, T., Sekiguchi, Y., Sellers, D., Sengupta, A.S., Blair, C.D., Sentenac, D., Seo, E.G., Sequino, V., Sergeev, A., Setyawati, Y., Shaffer, T., Shahriar, M.S., Shams, B., Shao, L., Sharma, A., Blair, D.G., Sharma, P., Shawhan, P., Shcheblanov, N.S., Shibagaki, S., Shikauchi, M., Shimizu, R., Shimoda, T., Shimode, K., Shinkai, H., Shishido, T., Blair, R.M., Shoda, A., Shoemaker, D.H., Shoemaker, D.M., Shyamsundar, S., Sieniawska, M., Sigg, D., Singer, L.P., Singh, D., Singh, N., Singha, A., Bobba, F., Sintes, A.M., Sipala, V., Skliris, V., Slagmolen, B.J.J., Slaven-Blair, T.J., Smetana, J., Smith, J.R., Smith, R.J.E., Soldateschi, J., Somala, S.N., Bode, N., Somiya, K., Son, E.J., Soni, K., Soni, S., Sordini, V., Sorrentino, F., Sorrentino, N., Sotani, H., Soulard, R., Souradeep, T., Boer, M., Sowell, E., Spagnuolo, V., Spencer, A.P., Spera, M., Srinivasan, R., Srivastava, A.K., Srivastava, V., Staats, K., Stachie, C., Steer, D.A., Bogaert, G., Steinhoff, J., Steinlechner, J., Steinlechner, S., Stevenson, S.P., Stops, D.J., Stover, M., Strain, K.A., Strang, L.C., Stratta, G., Strunk, A., Boldrini, M., Sturani, R., Stuver, A.L., Sudhagar, S., Sudhir, V., Sugimoto, R., Suh, H.G., Sullivan, A.G., Summerscales, T.Z., Sun, H., Sun, L., Aiello, L., Bonavena, L.D., Sunil, S., Sur, A., Suresh, J., Sutton, P.J., Suzuki, T., Swinkels, B.L., Szczepańczyk, M.J., Szewczyk, P., Tacca, M., Tagoshi, H., Bondu, F., Tait, S.C., Takahashi, H., Takahashi, R., Takamori, A., Takano, S., Takeda, H., Takeda, M., Talbot, C.J., Talbot, C., Tanaka, H., Bonilla, E., Tanaka, K., Tanaka, T., Tanasijczuk, A.J., Tanioka, S., Tanner, D.B., Tao, D., Tao, L., Martín, E.N.T.S., Taranto, C., Tasson, J.D., Bonnand, R., Telada, S., Tenorio, R., Terhune, J.E., Terkowski, L., Thirugnanasambandam, M.P., Thomas, L., Thomas, M., Thomas, P., Thompson, J.E., Thondapu, S.R., Booker, P., Thorne, K.A., Thrane, E., Tiwari, S., Tiwari, V., Toivonen, A.M., Toland, K., Tolley, A.E., Tomaru, T., Tomigami, Y., Tomura, T., Boom, B.A., Tonelli, M., Torres-Forné, A., Torrie, C.I., E Melo, I.T., Töyrä, D., Trapananti, A., Travasso, F., Traylor, G., Trevor, M., Tringali, M.C., Bork, R., Tripathee, A., Troiano, L., Trovato, A., Trozzo, L., Trudeau, R.J., Tsai, D.S., Tsai, D., Tsang, K.W., Tsang, T., Tsao, J.-S., Boschi, V., Tse, M., Tso, R., Tsubono, K., Tsuchida, S., Tsukada, L., Tsuna, D., Tsutsui, T., Tsuzuki, T., Turbang, K., Turconi, M., Bose, N., Tuyenbayev, D., Ubhi, A.S., Uchikata, N., Uchiyama, T., Udall, R.P., Ueda, A., Uehara, T., Ueno, K., Ueshima, G., Unnikrishnan, C.S., Bose, S., Uraguchi, F., Urban, A.L., Ushiba, T., Utina, A., Vahlbruch, H., Vajente, G., Vajpeyi, A., Valdes, G., Valentini, M., Valsan, V., Ain, A., Bossilkov, V., Van Bakel, N., Van Beuzekom, M., Van Den Brand, J.F.J., Van Den Broeck, C., Vander-Hyde, D.C., Van Der Schaaf, L., Van Heijningen, J.V., Vanosky, J., Van Putten, M.H.P.M., Van Remortel, N., Boudart, V., Vardaro, M., Vargas, A.F., Varma, V., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P.J., Venneberg, J., Venugopalan, G., Bouffanais, Y., Verkindt, D., Verma, P., Verma, Y., Veske, D., Vetrano, F., Viceré, A., Vidyant, S., Viets, A.D., Vijaykumar, A., Villa-Ortega, V., Bozzi, A., Vinet, J.-Y., Virtuoso, A., Vitale, S., Vo, T., Vocca, H., Von Reis, E.R.G., Von Wrangel, J.S.A., Vorvick, C., Vyatchanin, S.P., Wade, L.E., Bradaschia, C., Wade, M., Wagner, K.J., Walet, R.C., Walker, M., Wallace, G.S., Wallace, L., Walsh, S., Wang, J., Wang, J.Z., Wang, W.H., Brady, P.R., Ward, R.L., Warner, J., Was, M., Washimi, T., Washington, N.Y., Watchi, J., Weaver, B., Webster, S.A., Weinert, M., Weinstein, A.J., Bramley, A., Weiss, R., Weller, C.M., Wellmann, F., Wen, L., Weßels, P., Wette, K., Whelan, J.T., White, D.D., Whiting, B.F., Whittle, C., Branch, A., Wilken, D., Williams, D., Williams, M.J., Williamson, A.R., Willis, J.L., Willke, B., Wilson, D.J., Winkler, W., Wipf, C.C., Wlodarczyk, T., Branchesi, M., Woan, G., Woehler, J., Wofford, J.K., Wong, I.C.F., Wu, C., Wu, D.S., Wu, H., Wu, S., Wysocki, D.M., Xiao, L., Brandt, J., Xu, W.-R., Yamada, T., Yamamoto, H., Yamamoto, K., Yamamoto, T., Yamashita, K., Yamazaki, R., Yang, F.W., Yang, L., Yang, Y., Ajith, P., Brau, J.E., Yang, Z., Yap, M.J., Yeeles, D.W., Yelikar, A.B., Ying, M., Yokogawa, K., Yokoyama, J., Yokozawa, T., Yoo, J., Yoshioka, T., Breschi, M., Yu, H., Yuzurihara, H., Zadrożny, A., Zanolin, M., Zeidler, S., Zelenova, T., Zendri, J.-P., Zevin, M., Zhan, M., Zhang, H., Briant, T., Zhang, J., Zhang, L., Zhang, T., Zhang, Y., Zhao, C., Zhao, G., Zhao, Y., Zheng, Y., Zhou, R., Zhou, Z., Briggs, J.H., Zhu, X.J., Zhu, Z.-H., Zimmerman, A.B., Zlochower, Y., Zucker, M.E., Zweizig, J., (LIGO Scientific Collaboration, Virgo Collaboration, and KAGRA Collaboration), Brillet, A., Brinkmann, M., Brockill, P., Brooks, A.F., Brooks, J., Brown, D.D., Akutsu, T., Brunett, S., Bruno, G., Bruntz, R., Bryant, J., Bulik, T., Bulten, H.J., Buonanno, A., Buscicchio, R., Buskulic, D., Buy, C., De Alarcón, P.F., Byer, R.L., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J.C., Callaghan, J.D., Callister, T.A., Calloni, E., Cameron, J., Camp, J.B., Akcay, S., Canepa, M., Canevarolo, S., Cannavacciuolo, M., Cannon, K.C., Cao, H., Cao, Z., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Albanesi, S., Carlin, J.B., Carney, M.F., Carpinelli, M., Carrillo, G., Carullo, G., Carver, T.L., Diaz, J.C., Casentini, C., Castaldi, G., Caudill, S., Allocca, A., Cavaglià, M., Cavalier, F., Cavalieri, R., Ceasar, M., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakravarti, K., Subrahmanya, S.C., Altin, P.A., Champion, E., Chan, C.-H., Chan, C., Chan, C.L., Chan, K., Chan, M., Chandra, K., Chanial, P., Chao, S., Chapman-Bird, C.E.A., Amato, A., Charlton, P., Chase, E.A., Chassande-Mottin, E., Chatterjee, C., Chatterjee, D., Chaturvedi, M., Chaty, S., Chatziioannou, K., Chen, C., Chen, H.Y., Anand, C., Chen, J., Chen, K., Chen, X., Chen, Y.-B., Chen, Y.-R., Chen, Z., Cheng, H., Cheong, C.K., Cheung, H.Y., Chia, H.Y., Anand, S., Chiadini, F., Chiang, C.-Y., Chiarini, G., Chierici, R., Chincarini, A., Chiofalo, M.L., Chiummo, A., Cho, G., Cho, H.S., Choudhary, R.K., Ananyeva, A., Choudhary, S., Christensen, N., Chu, H., Chu, Q., Chu, Y.-K., Chua, S., Chung, K.W., Ciani, G., Ciecielag, P., Cieślar, M., Anderson, S.B., Cifaldi, M., Ciobanu, A.A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, E.N., Clark, J.A., Clarke, L., Clearwater, P., Anderson, W.G., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P.-F., Cohen, D.E., Cohen, L., Colleoni, M., Collette, C.G., Colombo, A., Ando, M., Colpi, M., Compton, C.M., Constancio, M., Jr., Conti, L., Cooper, S.J., Corban, P., Corbitt, T.R., Cordero-Carrión, I., Corezzi, S., Corley, K.R., Andrade, T., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C.A., Cotesta, R., Coughlin, M.W., Coulon, J.-P., Countryman, S.T., Cousins, B., Andres, N., Couvares, P., Coward, D.M., Cowart, M.J., Coyne, D.C., Coyne, R., Creighton, J.D.E., Creighton, T.D., Criswell, A.W., Croquette, M., Crowder, S.G., Andrić, T., Cudell, J.R., Cullen, T.J., Cumming, A., Cummings, R., Cunningham, L., Cuoco, E., Curyło, M., Dabadie, P., Canton, T.D., Dall'Osso, S., Angelova, S.V., Dálya, G., Dana, A., Daneshgaranbajastani, L.M., D'Angelo, B., Danila, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Ansoldi, S., Datrier, L.E.H., Datta, S., Dattilo, V., Dave, I., Davier, M., Davies, G.S., Davis, D., Davis, M.C., Daw, E.J., Dean, R., Antelis, J.M., Debra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Del Favero, V., De Lillo, F., De Lillo, N., Del Pozzo, W., Demarchi, L.M., Antier, S., De Matteis, F., D'Emilio, V., Demos, N., Dent, T., Depasse, A., De Pietri, R., De Rosa, R., De Rossi, C., Desalvo, R., De Simone, R., Antonini, F., Dhurandhar, S., Díaz, M.C., Diaz-Ortiz, M., Jr., Didio, N.A., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Appert, S., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A.K., Dmitriev, A., Doctor, Z., D'Onofrio, L., Arai, K., Donovan, F., Dooley, K.L., Doravari, S., Dorrington, I., Drago, M., Driggers, J.C., Drori, Y., Ducoin, J.-G., Dupej, P., Durante, O., Arai, Y., D'Urso, D., Duverne, P.-A., Dwyer, S.E., Eassa, C., Easter, P.J., Ebersold, M., Eckhardt, T., Eddolls, G., Edelman, B., Edo, T.B., Araki, S., Edy, O., Effler, A., Eguchi, S., Eichholz, J., Eikenberry, S.S., Eisenmann, M., Eisenstein, R.A., Ejlli, A., Engelby, E., Enomoto, Y., Araya, A., Errico, L., Essick, R.C., Estellés, H., Estevez, D., Etienne, Z., Etzel, T., Evans, M., Evans, T.M., Ewing, B.E., Fafone, V., Araya, M.C., Fair, H., Fairhurst, S., Farah, A.M., Farinon, S., Farr, B., Farr, W.M., Farrow, N.W., Fauchon-Jones, E.J., Favaro, G., Favata, M., Areeda, J.S., Fays, M., Fazio, M., Feicht, J., Fejer, M.M., Fenyvesi, E., Ferguson, D.L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T.A., Fidecaro, F., García-Arenal, Mercedes, Figura, P., Fiori, I., Fishbach, M., Fisher, R.P., Fittipaldi, R., Fiumara, V., Flaminio, R., Floden, E., Fong, H., Font, J.A., Aritomi, N., Fornal, B., Forsyth, P.W.F., Franke, A., Frasca, S., Frasconi, F., Frederick, C., Freed, J.P., Frei, Z., Freise, A., Frey, R., Arnaud, N., Fritschel, P., Frolov, V.V., Fronzé, G.G., Fujii, Y., Fujikawa, Y., Fukunaga, M., Fukushima, M., Fulda, P., Fyffe, M., Gabbard, H.A., Arogeti, M., Gadre, B.U., Gair, J.R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S.G., Garaventa, B., Aronson, S.M., García, F., García-Núñez, C., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Ge, G.-G., Gemme, G., Gennai, A., Arun, K.G., George, J., George, R.N., Gerberding, O., Gergely, L., Gewecke, P., Ghonge, S., Ghosh, A., Ghosh, S., Giacomazzo, B., Giacoppo, L., Asada, H., Giaime, J.A., Giardina, K.D., Gibson, D.R., Gier, C., Giesler, M., Giri, P., Gissi, F., Glanzer, J., Gleckl, A.E., Godwin, P., Asali, Y., Golomb, J., Goetz, E., Goetz, R., Gohlke, N., 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Arnaud, N., Fritschel, P., Frolov, V.V., Fronzé, G.G., Fujii, Y., Fujikawa, Y., Fukunaga, M., Fukushima, M., Fulda, P., Fyffe, M., Gabbard, H.A., Arogeti, M., Gadre, B.U., Gair, J.R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S.G., Garaventa, B., Aronson, S.M., García, F., García-Núñez, C., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Ge, G.-G., Gemme, G., Gennai, A., Arun, K.G., George, J., George, R.N., Gerberding, O., Gergely, L., Gewecke, P., Ghonge, S., Ghosh, A., Ghosh, S., Giacomazzo, B., Giacoppo, L., Asada, H., Giaime, J.A., Giardina, K.D., Gibson, D.R., Gier, C., Giesler, M., Giri, P., Gissi, F., Glanzer, J., Gleckl, A.E., Godwin, P., Asali, Y., Golomb, J., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gosselin, M., Gouaty, R., Gould, D.W., Ashton, G., Grace, B., Grado, A., Granata, M., Granata, V., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Aso, Y., Green, A.C., Green, R., Gretarsson, A.M., Gretarsson, E.M., Griffith, D., Griffiths, W., Griggs, H.L., Grignani, G., Grimaldi, A., Grimm, S.J., Assiduo, M., Grote, H., Grunewald, S., Gruning, P., Guerra, D., Guidi, G.M., Guimaraes, A.R., Guixé, G., Gulati, H.K., Guo, H.-K., Guo, Y., Aston, S.M., Gupta, A., Gupta, P., Gustafson, E.K., Gustafson, R., Guzman, F., Ha, S., Haegel, L., Hagiwara, A., Haino, S., Halim, O., Astone, P., Hall, E.D., Hamilton, E.Z., Hammond, G., Han, W.-B., Haney, M., Hanks, J., Hanna, C., Hannam, M.D., Hannuksela, O., Hansen, H., Aubin, F., Hansen, T.J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G.M., Harry, I.W., Hartwig, D., Hasegawa, K., Austin, C., Haskell, B., Hasskew, R.K., Haster, C.-J., Hattori, K., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F.J., Healy, J., Heidmann, A., Babak, S., Heidt, A., Heintze, M.C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A.F., Hemming, G., Hendry, M., Badaracco, F., Heng, I.S., Hennes, E., Hennig, J., Hennig, M.H., Hernandez, A.G., Vivanco, F.H., Heurs, M., Hild, S., Hill, P., Himemoto, Y., Bader, M.K.M., Hines, A.S., Hiranuma, Y., Hirata, N., Hirose, E., Hochheim, S., Hofman, D., Hohmann, J.N., Holcomb, D.G., Holland, N.A., Hollows, I.J., Badger, C., Holmes, Z.J., Holt, K., Holz, D.E., Hong, Z., Hopkins, P., Hough, J., Hourihane, S., Howell, E.J., Hoy, C.G., Hoyland, D., Bae, S., Hreibi, A., Hsieh, B.-H., Hsu, Y., Huang, G.-Z., Huang, H.-Y., Huang, P., Huang, Y.-C., Huang, Y.-J., Huang, Y., Hübner, M.T., Bae, Y., Huddart, A.D., Hughey, B., Hui, D.C.Y., Hui, V., Husa, S., Huttner, S.H., Huxford, R., Huynh-Dinh, T., Ide, S., Idzkowski, B., Baer, A.M., Iess, A., Ikenoue, B., Imam, S., Inayoshi, K., Ingram, C., Inoue, Y., Ioka, K., Isi, M., Isleif, K., Ito, K., Bagnasco, S., Itoh, Y., Iyer, B.R., Izumi, K., Jaberianhamedan, V., Jacqmin, T., Jadhav, S.J., Jadhav, S.P., James, A.L., Jan, A.Z., Jani, K., Bai, Y., Janquart, J., Janssens, K., Janthalur, N.N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A.C., Jenner, K., Jeon, C., Jeunon, M., Baiotti, L., Jia, W., Jin, H.-B., Johns, G.R., Jones, A.W., Jones, D.I., Jones, J.D., Jones, P., Jones, R., Jonker, R.J.G., Ju, L., Baird, J., Jung, P., Jung, K., Junker, J., Juste, V., Kaihotsu, K., Kajita, T., Kakizaki, M., Kalaghatgi, C.V., Kalogera, V., Kamai, B., Bajpai, R., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J.B., Kao, Y., Kapadia, S.J., Kapasi, D.P., Karat, S., Karathanasis, C., Ball, M., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaur, T., Kawabe, K., Kawaguchi, K., Ballardin, G., Kawai, N., Kawasaki, T., Kéfélian, F., Keitel, D., Key, J.S., Khadka, S., Khalili, F.Y., Khan, S., Khazanov, E.A., Khetan, N., Ballmer, S.W., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J.C., Kim, J., Kim, K., Kim, W.S., Kim, Y.-M., Kimball, C., Kimura, N., Balsamo, A., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J.S., Kita, N., Kitazawa, H., Kleybolte, L., Klimenko, S., Knee, A.M., Knowles, T.D., Knyazev, E., Baltus, G., Koch, P., Koekoek, G., Kojima, Y., Kokeyama, K., Koley, S., Kolitsidou, P., Kolstein, M., Komori, K., Kondrashov, V., Kong, A.K.H., Banagiri, S., Kontos, A., Koper, N., Korobko, M., Kotake, K., Kovalam, M., Kozak, D.B., Kozakai, C., Kozu, R., Kringel, V., Krishnendu, N.V., Bankar, D., Królak, A., Kuehn, G., Kuei, F., Kuijer, P., Kulkarni, S., Kumar, A., Kumar, P., Kumar, R., Kume, J., Kuns, K., Barayoga, J.C., Kuo, C., Kuo, H.-S., Kuromiya, Y., Kuroyanagi, Sachiko, Kusayanagi, K., Kuwahara, S., Kwak, K., Lagabbe, P., Laghi, D., Lalande, E., Barbieri, C., Lam, T.L., Lamberts, A., Landry, M., Landry, P., Lane, B.B., Lang, R.N., Lange, J., Lantz, B., La Rosa, I., Lartaux-Vollard, A., Barish, B.C., Lasky, P.D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y.K., Lee, H.K., Lee, H.M., Lee, H.W., Barker, D., Lee, J., Lee, K., Lee, R., Lehmann, J., Lemaître, A., Leonardi, M., Leroy, N., Letendre, N., Levesque, C., Levin, Y., Barneo, P., Leviton, J.N., Leyde, K., Li, A.K.Y., Li, B., Li, J., Li, K.L., Li, T.G.F., Li, X., Lin, C.-Y., Lin, F.-K., Barone, F., Lin, F.-L., Lin, H.L., Lin, L.C.-C., Linde, F., Linker, S.D., Linley, J.N., Littenberg, T.B., Liu, G.C., Liu, J., Liu, K., Barr, B., Liu, X., Llamas, F., Llorens-Monteagudo, M., Lo, R.K.L., Lockwood, A., Loh, M., London, L.T., Longo, A., Lopez, D., Portilla, M.L., Barsotti, L., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lott, T.P., Lough, J.D., Lousto, C.O., Lovelace, G., Lucaccioni, J.F., Lück, H., Barsuglia, M., Lumaca, D., Lundgren, A.P., Luo, L.-W., Lynam, J.E., Macas, R., Macinnis, M., Macleod, D.M., Macmillan, I.A.O., Macquet, A., Hernandez, I.M., Barta, D., Magazzù, C., Magee, R.M., Maggiore, R., Magnozzi, M., Mahesh, S., Majorana, E., Makarem, C., Maksimovic, I., Maliakal, S., Malik, A., Bartlett, J., Man, N., Mandic, V., Mangano, V., Mango, J.L., Mansell, G.L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marchio, M., Barton, M.A., Marion, F., Mark, Z., Márka, S., Márka, Z., Markakis, C., Markosyan, A.S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Bartos, I., Martelli, F., Martin, I.W., Martin, R.M., Martinez, M., Martinez, V.A., Martinez, V., Martinovic, K., Martynov, D.V., Marx, E.J., Masalehdan, H., Bassiri, R., Mason, K., Massera, E., Masserot, A., Massinger, T.J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Mateu-Lucena, M., Matichard, F., Matiushechkina, M., Basti, A., Mavalvala, N., McCann, J.J., McCarthy, R., McClelland, D.E., McClincy, P.K., McCormick, S., McCuller, L., McGhee, G.I., McGuire, S.C., McIsaac, C., Bawaj, M., McIver, J., McRae, T., McWilliams, S.T., Meacher, D., Mehmet, M., Mehta, A.K., Meijer, Q., Melatos, A., Melchor, D.A., Mendell, G., Bayley, J.C., Menendez-Vazquez, A., Menoni, C.S., Mercer, R.A., Mereni, L., Merfeld, K., Merilh, E.L., Merritt, J.D., Merzougui, M., Meshkov, S., Messenger, C., Baylor, A.C., Messick, C., Meyers, P.M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Bazzan, M., Milano, L., Miller, A.L., Miller, A., Miller, B., Miller, S., Millhouse, M., Mills, J.C., Milotti, E., Minazzoli, O., Minenkov, Y., Bécsy, B., Mio, N., Mir, L.M., Miravet-Tenés, M., Mishra, C., Mishra, T., Mistry, T., Mitra, S., Mitrofanov, V.P., Mitselmakher, G., Mittleman, R., Bedakihale, V.M., Miyakawa, O., Miyamoto, A., Miyazaki, Y., Miyo, K., Miyoki, S., Mo, G., Modafferi, L.M., Moguel, E., Mogushi, K., and Mohapatra, S.R.P.

Published
2023

31. EBV-DRIVEN LYMPHOID NEOPLASMS ASSOCIATED WITH ALL MAINTENANCE THERAPY: AN INTERNATIONAL OBSERVATINAL STUDY

Author

Elitzur, S., primary, Vora, A., additional, Burkhardt, B., additional, Inaba, H., additional, Attarbaschi, A., additional, Baruchel, A., additional, Escherich, G., additional, Gibson, B., additional, Liu, H., additional, Loh, M., additional, Moorman, A., additional, Moricke, A., additional, Pieters, R., additional, Uyttebroeck, A., additional, Baird, S., additional, Bartram, J., additional, Ben-Harosh, M., additional, Bertrand, Y., additional, Buitenkamp, T., additional, Caldwell, K., additional, Drut, R., additional, Geerlinks, A., additional, Grainger, J., additional, Haouy, S., additional, Heaney, N., additional, Huang, M., additional, Ingham, D., additional, Krenova, Z., additional, Kuhlen, M., additional, Lehrnbecher, T., additional, Manabe, A., additional, Niggli, F., additional, Paris, C., additional, Revel-Vilk, S., additional, Rohrlich, P., additional, Sandeep, B., additional, Sinno, M., additional, Szczepanski, T., additional, Tamesberger, M., additional, Warrier, R., additional, Wolfl, M., additional, Nirel, R., additional, Izraeli, S., additional, Borkhardt, A., additional, and Schmiegelow, K., additional

Published
2022
Full Text
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32. A TARGETED GENE EXPRESSION CLASSIFIER IDENTIFIES PEDIATRIC T-ALL PATIENTS AT HIGH RISK FOR END INDUCTION MINIMAL RESIDUAL DISEASE POSITIVITY

Author

Meyer, L., primary, Roy, Ritu P., additional, Huang, B., additional, Kimura, S., additional, Polonen, Petri, additional, Delgado-Martin, C., additional, Vincent, T., additional, Ryan, T., additional, Wood, B., additional, Liu, Y., additional, Zhang, J., additional, Mullighan, C., additional, Horton, T., additional, Loh, M., additional, Devidas, M., additional, Raetz, E., additional, Hayashi, R., additional, Winter, S., additional, Dunsmore, K., additional, Hunger, S., additional, Teachey, D., additional, Hermiston, M., additional, and Olshen, Adam B., additional

Published
2022
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33. The effect of job demands on health and work outcomes: A longitudinal study among Malaysian employees

Author

Nurfazreen Aina Muhamad Nasharudin, Loh M. Young, Mohd Awang B Idris, Muhamad Nasharudin, Nurfazreen Aina, Idris, Mohd Awang, and Young, Loh M

Subjects
work engagement, Longitudinal study, Emotions, Applied psychology, Workload, Burnout, Affect (psychology), Job Satisfaction, Structural equation modeling, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, 0502 economics and business, Humans, Longitudinal Studies, 030212 general & internal medicine, Burnout, Professional, General Psychology, sleep problems, burnout, Work engagement, 05 social sciences, Work Engagement, job performance, job demands, Work (electrical), Job performance, Psychology, 050203 business & management
Abstract

The purpose of the current study was to investigate the impact of job demands on health and work outcomes among Malaysian workers. We hypothesized that job demands (i.e., emotional demands and physical demands) would predict future work‐related burnout and work engagement, in turn affecting sleep problems and job performance (in‐role, extra‐role). A longitudinal two‐wave survey was conducted among Malaysian workers and valid data from 345 participants were analyzed using structural equation modeling. The results revealed that work‐related burnout predicts sleep problems while work engagement increased employees' job performance over time. Overall, the current study highlights the importance of specific job demands (i.e., emotional demands and physical demands) that specifically affect health‐related behavior and work‐related behavior among workers. Refereed/Peer-reviewed

Published
2020

34. Clinical characteristics and outcomes of B-ALL with ZNF384 rearrangements: a retrospective analysis by the Ponte di Legno Childhood ALL Working Group

Author

Hirabayashi, S, Butler, E, Ohki, K, Kiyokawa, N, Bergmann, A, Moricke, A, Boer, J, Cave, H, Cazzaniga, G, Yeoh, A, Sanada, M, Imamura, T, Inaba, H, Mullighan, C, Loh, M, Noren-Nystrom, U, Pastorczak, A, Shih, L, Zaliova, M, Pui, C, Haas, O, Harrison, C, Moorman, A, Manabe, A, Hirabayashi S., Butler E. R., Ohki K., Kiyokawa N., Bergmann A. K., Moricke A., Boer J. M., Cave H., Cazzaniga G., Yeoh A. E. J., Sanada M., Imamura T., Inaba H., Mullighan C., Loh M. L., Noren-Nystrom U., Pastorczak A., Shih L. -Y., Zaliova M., Pui C. -H., Haas O. A., Harrison C. J., Moorman A. V., Manabe A., Hirabayashi, S, Butler, E, Ohki, K, Kiyokawa, N, Bergmann, A, Moricke, A, Boer, J, Cave, H, Cazzaniga, G, Yeoh, A, Sanada, M, Imamura, T, Inaba, H, Mullighan, C, Loh, M, Noren-Nystrom, U, Pastorczak, A, Shih, L, Zaliova, M, Pui, C, Haas, O, Harrison, C, Moorman, A, Manabe, A, Hirabayashi S., Butler E. R., Ohki K., Kiyokawa N., Bergmann A. K., Moricke A., Boer J. M., Cave H., Cazzaniga G., Yeoh A. E. J., Sanada M., Imamura T., Inaba H., Mullighan C., Loh M. L., Noren-Nystrom U., Pastorczak A., Shih L. -Y., Zaliova M., Pui C. -H., Haas O. A., Harrison C. J., Moorman A. V., and Manabe A.

Published
2021

35. Outcomes of paediatric patients with B-cell acute lymphocytic leukaemia with ABL-class fusion in the pre-tyrosine-kinase inhibitor era: a multicentre, retrospective, cohort study

Author

den Boer, M, Cario, G, Moorman, A, Boer, J, de Groot-Kruseman, H, Fiocco, M, Escherich, G, Imamura, T, Yeoh, A, Sutton, R, Dalla-Pozza, L, Kiyokawa, N, Schrappe, M, Roberts, K, Mullighan, C, Hunger, S, Vora, A, Attarbaschi, A, Zaliova, M, Elitzur, S, Cazzaniga, G, Biondi, A, Loh, M, Pieters, R, den Boer M. L., Cario G., Moorman A. V., Boer J. M., de Groot-Kruseman H. A., Fiocco M., Escherich G., Imamura T., Yeoh A., Sutton R., Dalla-Pozza L., Kiyokawa N., Schrappe M., Roberts K. G., Mullighan C. G., Hunger S. P., Vora A., Attarbaschi A., Zaliova M., Elitzur S., Cazzaniga G., Biondi A., Loh M. L., Pieters R., den Boer, M, Cario, G, Moorman, A, Boer, J, de Groot-Kruseman, H, Fiocco, M, Escherich, G, Imamura, T, Yeoh, A, Sutton, R, Dalla-Pozza, L, Kiyokawa, N, Schrappe, M, Roberts, K, Mullighan, C, Hunger, S, Vora, A, Attarbaschi, A, Zaliova, M, Elitzur, S, Cazzaniga, G, Biondi, A, Loh, M, Pieters, R, den Boer M. L., Cario G., Moorman A. V., Boer J. M., de Groot-Kruseman H. A., Fiocco M., Escherich G., Imamura T., Yeoh A., Sutton R., Dalla-Pozza L., Kiyokawa N., Schrappe M., Roberts K. G., Mullighan C. G., Hunger S. P., Vora A., Attarbaschi A., Zaliova M., Elitzur S., Cazzaniga G., Biondi A., Loh M. L., and Pieters R.

Abstract

Background: ABL-class fusion genes other than BCR–ABL1 have been identified in approximately 3% of children with newly diagnosed acute lymphocytic leukaemia, and studies suggest that leukaemic cells carrying ABL-class fusions can be targeted successfully by tyrosine-kinase inhibitors. We aimed to establish the baseline characteristics and outcomes of paediatric patients with ABL-class fusion B-cell acute lymphocytic leukaemia in the pre-tyrosine-kinase inhibitor era. Methods: This multicentre, retrospective, cohort study included paediatric patients (aged 1–18 years) with newly diagnosed ABL-class fusion (ABL1 fusion-positive, ABL2 fusion-positive, CSF1R fusion-positive, and PDGFRB fusion-positive) B-cell acute lymphocytic leukaemia enrolled in clinical trials of multidrug chemotherapy done between Oct 3, 2000, and Aug 28, 2018, in which tyrosine-kinase inhibitors had not been given as a first-line treatment. Patients from 14 European, North American, and Asia-Pacific study groups of the Ponte di Legno group were included. No patients were excluded, and patients were followed up by individual study groups. Through the Ponte di Legno group, we collected data on the baseline characteristics of patients, including IKZF1, PAX5, and CDKN2A/B deletion status, and whether haematopoietic stem cell transplantation (HSCT) had been done, as well as treatment outcomes, including complete remission, no response, relapse, early death, and treatment-related mortality, response to prednisone, and minimal residual disease (MRD) at end of induction therapy. 5-year event-free survival and 5-year overall survival were estimated by use of Kaplan-Meier methods, and the 5-year cumulative incidence of relapse was calculated by use of a competing risk model. Findings: We identified 122 paediatric patients with newly diagnosed ABL-class fusion B-cell acute lymphocytic leukaemia (77 from European study groups, 25 from North American study groups, and 20 from Asia-Pacific study groups). 64 (52

Published
2021

36. MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children’s Oncology Group Study

Author

Matlawska-Wasowska, K, Kang, H, Devidas, M, Wen, J, Harvey, R C, Nickl, C K, Ness, S A, Rusch, M, Li, Y, Onozawa, M, Martinez, C, Wood, B L, Asselin, B L, Chen, I-M, Roberts, K G, Baruchel, A, Soulier, J, Dombret, H, Zhang, J, Larson, R S, Raetz, E A, Carroll, W L, Winick, N J, Aplan, P D, Loh, M L, Mullighan, C G, Hunger, S P, Heerema, N A, Carroll, A J, Dunsmore, K P, and Winter, S S

Published
2016
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37. The population of merging compact binaries inferred using gravitational waves through GWTC-3

Author

Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., Adhikari, N., Adhikari, R. X., Adya, V. B., Affeldt, C., Agarwal, D., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aiello, L., Ain, A., Ajith, P., Akutsu, T., de Alarcón, P. F., Akcay, S., Albanesi, S., Allocca, A., Altin, P. A., Amato, A., Anand, C., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Ando, M., Andrade, T., Andres, N., Andrić, T., Angelova, S. V., Ansoldi, S., Antelis, J. M., Antier, S., Antonini, F., Appert, S., Arai, Koji, Arai, Koya, Arai, Y., Araki, S., Araya, A., Araya, M. C., Areeda, J. S., Arène, M., Aritomi, N., Arnaud, N., Arogeti, M., Aronson, S. M., Arun, K. G., Asada, H., Asali, Y., Ashton, G., Aso, Y., Assiduo, M., Aston, S. M., Astone, P., Aubin, F., Austin, C., Babak, S., Badaracco, F., Bader, M. K. M., Badger, C., Bae, S., Bae, Y., Baer, A. M., Bagnasco, S., Bai, Y., Baiotti, L., Baird, J., Bajpai, R., Ball, M., Ballardin, G., Ballmer, S. W., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Barton, M. A., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Baylor, A. C., Bazzan, M., Bécsy, B., Bedakihale, V. M., Bejger, M., Belahcene, I., Benedetto, V., Beniwal, D., Bennett, T. F., Bentley, J. D., Benyaala, M., Bergamin, F., Berger, B. K., Bernuzzi, S., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Beveridge, D., Bhandare, R., Bhardwaj, U., Bhattacharjee, D., Bhaumik, S., Bilenko, I. A., Billingsley, G., Bini, S., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Biswas, B., Bitossi, M., Bizouard, M. -A., Blackburn, J. K., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Bogaert, G., Boldrini, M., Bonavena, L. D., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, N., Bose, S., Bossilkov, V., Boudart, V., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branch, A., Branchesi, M., Brandt, J., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., BRUNO, Giovanni, Bruntz, R., Bryant, J., Bulik, T., Bulten, H. J., Buonanno, A., Buscicchio, R., Buskulic, D., Buy, C., Byer, R. L., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Cameron, J., Camp, J. B., Canepa, M., Canevarolo, S., Cannavacciuolo, M., Cannon, K. C., Cao, H., Cao, Z., Capocasa, E., Capote, E., Carapella, G., Carbognani, F., Carlin, J. B., Carney, M. F., Carpinelli, M., Carrillo, G., Carullo, G., Carver, T. L., Diaz, J. Casanueva, CASENTINI, CLAUDIO, Castaldi, G., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Ceasar, M., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, W., Chakravarti, K., Subrahmanya, S. Chalathadka, Champion, E., Chan, C. -H., Chan, C., Chan, C. L., Chan, K., Chan, M., Chandra, K., Chanial, P., Chao, S., Chapman-Bird, C. E. A., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, C., Chatterjee, Debarati, Chatterjee, Deep, Chaturvedi, M., Chaty, S., Chatziioannou, K., Chen, C., Chen, H. Y., Chen, J., Chen, K., Chen, X., Chen, Y. -B., Chen, Y. -R., Chen, Z., Cheng, H., Cheong, C. K., Cheung, H. Y., Chia, H. Y., Chiadini, F., Chiang, C. -Y., Chiarini, G., Chierici, R., Chincarini, A., Chiofalo, M. L., Chiummo, A., Cho, G., Cho, H. S., Choudhary, R. K., Choudhary, S., Christensen, N., Chu, H., Chu, Q., Chu, Y. -K., Chua, S., Chung, K. W., Ciani, G., Ciecielag, P., Cieślar, M., Cifaldi, M., Ciobanu, A. A., CIOLFI, RICCARDO, Cipriano, F., Cirone, A., Clara, F., Clark, E. N., Clark, J. A., Clarke, L., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Codazzo, E., Cohadon, P. -F., Cohen, D. E., Cohen, L., Colleoni, M., Collette, C. G., Colombo, A., Colpi, M., Compton, C. M., Constancio, M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coulon, J. -P., Countryman, S. T., Cousins, B., Couvares, P., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Criswell, A. W., Croquette, M., Crowder, S. G., Cudell, J. R., Cullen, T. J., Cumming, A., Cummings, R., Cunningham, L., Cuoco, E., Curyło, M., Dabadie, P., Canton, T. Dal, Dall'Osso, S., Dálya, G., Dana, A., Daneshgaranbajastani, L. M., D'Angelo, B., Danila, B., Danilishin, S., D'Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. 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B., Edy, O., Effler, A., Eguchi, S., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Engelby, E., Enomoto, Y., ERRICO, Luigi, Essick, R. C., Estellés, H., Estevez, D., Etienne, Z., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fair, H., Fairhurst, S., Farah, A. M., Farinon, S., Farr, B., Farr, W. M., Farrow, N. W., Fauchon-Jones, E. J., Favaro, G., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, T. A., Fidecaro, F., Figura, P., Fiori, I., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fiumara, V., Flaminio, R., Floden, E., Fong, H., Font, J. A., Fornal, B., Forsyth, P. W. F., Franke, A., Frasca, S., Frasconi, F., Frederick, C., Freed, J. P., Frei, Z., Freise, A., Frey, R., Fritschel, P., Frolov, V. V., Fronzé, G. G., Fujii, Y., Fujikawa, Y., Fukunaga, M., Fukushima, M., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gair, J. R., Gais, J., Galaudage, S., Gamba, R., Ganapathy, D., Ganguly, A., Gao, D., Gaonkar, S. G., Garaventa, B., García, F., García-Núñez, C., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Ge, G. -G., Gemme, G., Gennai, A., George, J., George, R. N., Gerberding, O., Gergely, L., Gewecke, P., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, Shaon, Ghosh, Shrobana, Giacomazzo, B., Giacoppo, L., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Giesler, M., Giri, P., Gissi, F., Glanzer, J., Gleckl, A. E., Godwin, P., Golomb, J., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gosselin, M., Gouaty, R., Gould, D. W., Grace, B., GRADO, ANIELLO, Granata, M., Granata, V., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, A. M., Gretarsson, E. M., Griffith, D., Griffiths, W., Griggs, H. L., Grignani, G., Grimaldi, A., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guerra, D., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, H. -K., Guo, Y., Gupta, Anchal, Gupta, Anuradha, Gupta, P., Gustafson, E. K., Gustafson, R., Guzman, F., Ha, S., Haegel, L., Hagiwara, A., Haino, S., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Han, W. -B., Haney, M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O., Hansen, H., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hartwig, D., Hasegawa, K., Haskell, B., Hasskew, R. K., Haster, C. -J., Hattori, K., Haughian, K., Hayakawa, H., Hayama, K., Hayes, F. J., Healy, J., Heidmann, A., Heidt, A., Heintze, M. C., Heinze, J., Heinzel, J., Heitmann, H., Hellman, F., Hello, P., Helmling-Cornell, A. F., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Hennig, M. H., Hernandez, A. G., Vivanco, F. Hernandez, Heurs, M., Hild, S., Hill, P., Himemoto, Y., Hines, A. S., Hiranuma, Y., Hirata, N., Hirose, E., Hochheim, S., Hofman, D., Hohmann, J. N., Holcomb, D. G., Holland, N. A., Hollows, I. J., Holmes, Z. J., Holt, K., Holz, D. E., Hong, Z., Hopkins, P., Hough, J., Hourihane, S., Howell, E. J., Hoy, C. G., Hoyland, D., Hreibi, A., Hsieh, B. -H., Hsu, Y., Huang, G. -Z., Huang, H. -Y., Huang, P., Huang, Y. -C., Huang, Y. -J., Huang, Y., Hübner, M. T., Huddart, A. D., Hughey, B., Hui, D. C. Y., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Ide, S., Idzkowski, B., Iess, A., Ikenoue, B., Imam, S., Inayoshi, K., Ingram, C., Inoue, Y., Ioka, K., Isi, M., Isleif, K., Ito, K., Itoh, Y., Iyer, B. R., Izumi, K., Jaberianhamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jan, A. Z., Jani, K., Janquart, J., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jenner, K., Jeon, C., Jeunon, M., Jia, W., Jin, H. -B., Johns, G. R., Jones, A. W., Jones, D. I., Jones, J. 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H., Huxford, R., Huynh-Dinh, T., Ide, S., Idzkowski, B., Iess, A., Ikenoue, B., Imam, S., Inayoshi, K., Ingram, C., Inoue, Y., Ioka, K., Isi, M., Isleif, K., Ito, K., Itoh, Y., Iyer, B. R., Izumi, K., Jaberianhamedan, V., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jan, A. Z., Jani, K., Janquart, J., Janssens, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jenner, K., Jeon, C., Jeunon, M., Jia, W., Jin, H. -B., Johns, G. R., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Jung, P., Jung, K., Junker, J., Juste, V., Kaihotsu, K., Kajita, T., Kakizaki, M., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kamiizumi, M., Kanda, N., Kandhasamy, S., Kang, G., Kanner, J. B., Kao, Y., Kapadia, S. J., Kapasi, D. P., Karat, S., Karathanasis, C., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaur, T., Kawabe, K., Kawaguchi, K., Kawai, N., Kawasaki, T., Kéfélian, F., Keitel, D., Key, J. S., Khadka, S., Khalili, F. Y., Khan, S., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, J., Kim, K., Kim, W. S., Kim, Y. -M., Kimball, C., Kimura, N., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kita, N., Kitazawa, H., Kleybolte, L., Klimenko, S., Knee, A. M., Knowles, T. D., Knyazev, E., Koch, P., Koekoek, G., Kojima, Y., Kokeyama, K., Koley, S., Kolitsidou, P., Kolstein, M., Komori, K., Kondrashov, V., Kong, A. K. H., Kontos, A., Koper, N., Korobko, M., Kotake, K., Kovalam, M., Kozak, D. B., Kozakai, C., Kozu, R., Kringel, V., Krishnendu, N. V., Królak, A., Kuehn, G., Kuei, F., Kuijer, P., Kulkarni, S., Kumar, A., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kume, J., Kuns, K., Kuo, C., Kuo, H-S., Kuromiya, Y., Kuroyanagi, S., Kusayanagi, K., Kuwahara, S., Kwak, K., Lagabbe, P., Laghi, D., Lalande, E., Lam, T. L., Lamberts, A., Landry, M., Landry, P., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y. K., Lee, H. K., Lee, H. M., Lee, H. W., Lee, J., Lee, K., Lee, R., Lehmann, J., Lemaître, A., Leonardi, M., Leroy, N., Letendre, N., Levesque, C., Levin, Y., Leviton, J. N., Leyde, K., Li, A. K. Y., Li, B., Li, J., Li, K. L., Li, T. G. F., Li, X., Lin, C-Y., Lin, F-K., Lin, F-L., Lin, H. L., Lin, L. C. -C., Linde, F., Linker, S. D., Linley, J. N., Littenberg, T. B., Liu, G. C., Liu, J., Liu, K., Liu, X., Llamas, F., Llorens-Monteagudo, M., Lo, R. K. L., Lockwood, A., Loh, M., London, L. T., Longo, A., Lopez, D., Portilla, M. Lopez, Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lott, T. P., Lough, J. D., Lousto, C. O., Lovelace, G., Lucaccioni, J. F., Lück, H., Lumaca, D., Lundgren, A. P., Luo, L. -W., Lynam, J. E., Macas, R., Macinnis, M., Macleod, D. M., Macmillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magazzù, C., Magee, R. M., Maggiore, R., Magnozzi, M., Mahesh, S., Majorana, E., Makarem, C., Maksimovic, I., Maliakal, S., Malik, A., Man, N., Mandic, V., Mangano, V., Mango, J. L., Mansell, G. L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marchio, M., Marion, F., Mark, Z., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, M., Martinez, V. A., Martinez, V., Martinovic, K., Martynov, D. V., Marx, E. J., Masalehdan, H., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Mateu-Lucena, M., Matichard, F., Matiushechkina, M., Mavalvala, N., Mccann, J. J., Mccarthy, R., Mcclelland, D. E., Mcclincy, P. K., Mccormick, S., Mcculler, L., Mcghee, G. I., Mcguire, S. C., Mcisaac, C., Mciver, J., Mcrae, T., Mcwilliams, S. T., Meacher, D., Mehmet, M., Mehta, A. K., Meijer, Q., Melatos, A., Melchor, D. A., Mendell, G., Menendez-Vazquez, A., Menoni, C. S., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Michimura, Y., Middleton, H., Milano, L., Miller, A. L., Miller, A., Miller, B., Miller, S., Millhouse, M., Mills, J. C., Milotti, E., Minazzoli, O., Minenkov, Y., Mio, N., Mir, Ll. M., Miravet-Tenés, M., Mishra, C., Mishra, T., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Miyakawa, O., Miyamoto, A., Miyazaki, Y., Miyo, K., Miyoki, S., Mo, Geoffrey, Modafferi, L. M., Moguel, E., Mogushi, K., Mohapatra, S. R. P., Mohite, S. R., Molina, I., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C. J., Moraru, D., Morawski, F., More, A., Moreno, C., Moreno, G., Mori, Y., Morisaki, S., Moriwaki, Y., Morrás, G., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, Soma, Mukherjee, Subroto, Mukherjee, Suvodip, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Musenich, R., Muusse, S., Nadji, S. L., Nagano, K., Nagano, S., Nagar, A., Nakamura, K., Nakano, H., Nakano, M., Nakashima, R., Nakayama, Y., Napolano, V., Nardecchia, I., Narikawa, T., Naticchioni, L., Nayak, B., Nayak, R. K., Negishi, R., Neil, B. F., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neubauer, P., Neunzert, A., Ng, K. Y., Ng, S. W. S., Nguyen, C., Nguyen, P., Nguyen, T., Quynh, L. Nguyen, Ni, W. -T., Nichols, S. A., Nishizawa, A., Nissanke, S., Nitoglia, E., Nocera, F., Norman, M., North, C., Nozaki, S., Siles, J. F. Nuño, Nuttall, L. K., Oberling, J., O’Brien, B. D., Obuchi, Y., O’Dell, J., Oelker, E., Ogaki, W., Oganesyan, G., Oh, J. J., Oh, K., Oh, S. H., Ohashi, M., Ohishi, N., Ohkawa, M., Ohme, F., Ohta, H., Okada, M. A., Okutani, Y., Okutomi, K., Olivetto, C., Oohara, K., Ooi, C., Oram, R., O’Reilly, B., Ormiston, R. G., Ormsby, N. D., Ortega, L. F., O’Shaughnessy, R., O’Shea, E., Oshino, S., Ossokine, S., Osthelder, C., Otabe, S., Ottaway, D. J., Overmier, H., Pace, A. E., Pagano, G., Page, M. A., Pagliaroli, G., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pan, H., Pan, K., Panda, P. K., Pang, H., Pang, P. T. H., Pankow, C., Pannarale, F., Pant, B. C., Panther, F. H., Paoletti, F., Paoli, A., Paolone, A., Parisi, A., Park, H., Park, J., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patel, M., Pathak, M., Patricelli, B., Patron, A. S., Paul, S., Payne, E., Pedraza, M., Pegoraro, M., Pele, A., Arellano, F. E. Peña, Penn, S., Perego, A., Pereira, A., Pereira, T., Perez, C. J., Périgois, C., Perkins, C. C., Perreca, A., Perriès, S., Petermann, J., Petterson, D., Pfeiffer, H. P., Pham, K. A., Phukon, K. S., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierini, L., Pierro, V., Pillant, G., Pillas, M., Pilo, F., Pinard, L., Pinto, I. M., Pinto, M., Piotrzkowski, B., Piotrzkowski, K., Pirello, M., Pitkin, M. D., Placidi, E., Planas, L., Plastino, W., Pluchar, C., Poggiani, R., Polini, E., Pong, D. Y. T., Ponrathnam, S., Popolizio, P., Porter, E. K., Poulton, R., Powell, J., Pracchia, M., Pradier, T., Prajapati, A. K., Prasai, K., Prasanna, R., Pratten, G., Principe, M., Prodi, G. A., Prokhorov, L., Prosposito, P., Prudenzi, L., Puecher, A., Punturo, M., Puosi, F., Puppo, P., Pürrer, M., Qi, H., Quetschke, V., Quitzow-James, R., Raab, F. J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rail, S. X., Raja, S., Rajan, C., Ramirez, K. E., Ramirez, T. D., Ramos-Buades, A., Rana, J., Rapagnani, P., Rapol, U. D., Ray, A., Raymond, V., Raza, N., Razzano, M., Read, J., Rees, L. A., Regimbau, T., Rei, L., Reid, S., Reid, S. W., Reitze, D. H., Relton, P., Renzini, A., Rettegno, P., Reza, A., Rezac, M., Ricci, F., Richards, D., Richardson, J. W., Richardson, L., Riemenschneider, G., Riles, K., Rinaldi, S., Rink, K., Rizzo, M., Robertson, N. A., Robie, R., Robinet, F., Rocchi, A., Rodriguez, S., Rolland, L., Rollins, J. G., Romanelli, M., Romano, R., Romel, C. L., Romero-Rodríguez, A., Romero-Shaw, I. M., Romie, J. H., Ronchini, S., Rosa, L., Rose, C. A., Rosińska, D., Ross, M. P., Rowan, S., Rowlinson, S. J., Roy, S., Roy, Santosh, Roy, Soumen, Rozza, D., Ruggi, P., Ryan, K., Sachdev, S., Sadecki, T., Sadiq, J., Sago, N., Saito, S., Saito, Y., Sakai, K., Sakai, Y., Sakellariadou, M., Sakuno, Y., Salafia, O. S., Salconi, L., Saleem, M., Salemi, F., Samajdar, A., Sanchez, E. J., Sanchez, J. H., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Sanuy, A., Saravanan, T. R., Sarin, N., Sassolas, B., Satari, H., Sathyaprakash, B. S., Sato, S., Sato, T., Sauter, O., Savage, R. L., Sawada, T., Sawant, D., Sawant, H. L., Sayah, S., Schaetzl, D., Scheel, M., Scheuer, J., Schiworski, M., Schmidt, P., Schmidt, S., Schnabel, R., Schneewind, M., Schofield, R. M. S., Schönbeck, A., Schulte, B. W., Schutz, B. F., Schwartz, E., Scott, J., Scott, S. M., Seglar-Arroyo, M., Sekiguchi, T., Sekiguchi, Y., Sellers, D., Sengupta, A. S., Sentenac, D., Seo, E. G., Sequino, V., Sergeev, A., Setyawati, Y., Shaffer, T., Shahriar, M. S., Shams, B., Shao, L., Sharma, A., Sharma, P., Shawhan, P., Shcheblanov, N. S., Shibagaki, S., Shikauchi, M., Shimizu, R., Shimoda, T., Shimode, K., Shinkai, H., Shishido, T., Shoda, A., Shoemaker, D. H., Shoemaker, D. M., Shyamsundar, S., Sieniawska, M., Sigg, D., Singer, L. P., Singh, D., Singh, N., Singha, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, R. J. E., Soldateschi, J., Somala, S. N., Somiya, K., Son, E. J., Soni, K., Soni, S., Sordini, V., Sorrentino, F., Sorrentino, N., Sotani, H., Soulard, R., Souradeep, T., Sowell, E., Spagnuolo, V., Spencer, A. P., Spera, M., Srinivasan, R., Srivastava, A. K., Srivastava, V., Staats, K., Stachie, C., Steer, D. A., Steinhoff, J., Steinlechner, J., Steinlechner, S., Stevenson, S. P., Stops, D. J., Stover, M., Strain, K. A., Strang, L. C., Stratta, G., Strunk, A., Sturani, R., Stuver, A. L., Sudhagar, S., Sudhir, V., Sugimoto, R., Suh, H. G., Sullivan, A. G., Summerscales, T. Z., Sun, H., Sun, L., Sunil, S., Sur, A., Suresh, J., Sutton, P. J., Suzuki, Takamasa, Suzuki, Toshikazu, Swinkels, B. L., Szczepańczyk, M. J., Szewczyk, P., Tacca, M., Tagoshi, H., Tait, S. C., Takahashi, H., Takahashi, R., Takamori, A., Takano, S., Takeda, H., Takeda, M., Talbot, C. J., Talbot, C., Tanaka, H., Tanaka, Kazuyuki, Tanaka, Kenta, Tanaka, Taiki, Tanaka, Takahiro, Tanasijczuk, A. J., Tanioka, S., Tanner, D. B., Tao, D., Tao, L., Martín, E. N. Tapia San, Taranto, C., Tasson, J. D., Telada, S., Tenorio, R., Terhune, J. E., Terkowski, L., Thirugnanasambandam, M. P., Thomas, L., Thomas, M., Thomas, P., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tiwari, Shubhanshu, Tiwari, Srishti, Tiwari, V., Toivonen, A. M., Toland, K., Tolley, A. E., Tomaru, T., Tomigami, Y., Tomura, T., Tonelli, M., Torres-Forné, A., Torrie, C. I., e Melo, I. Tosta, Töyrä, D., Trapananti, A., Travasso, F., Traylor, G., Trevor, M., Tringali, M. C., Tripathee, A., Troiano, L., Trovato, A., Trozzo, L., Trudeau, R. J., Tsai, D. S., Tsai, D., Tsang, K. W., Tsang, T., Tsao, J-S., Tse, M., Tso, R., Tsubono, K., Tsuchida, S., Tsukada, L., Tsuna, D., Tsutsui, T., Tsuzuki, T., Turbang, K., Turconi, M., Tuyenbayev, D., Ubhi, A. S., Uchikata, N., Uchiyama, T., Udall, R. P., Ueda, A., Uehara, T., Ueno, K., Ueshima, G., Unnikrishnan, C. S., Uraguchi, F., Urban, A. L., Ushiba, T., Utina, A., Vahlbruch, H., Vajente, G., Vajpeyi, A., Valdes, G., Valentini, M., Valsan, V., van Bakel, N., van Beuzekom, M., van den Brand, J. F. J., Van Den Broeck, C., Vander-Hyde, D. C., van der Schaaf, L., van Heijningen, J. V., Vanosky, J., van Putten, M. H. P. M., van Remortel, N., Vardaro, M., Vargas, A. F., Varma, V., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venneberg, J., Venugopalan, G., Verkindt, D., Verma, P., Verma, Y., Veske, D., Vetrano, F., Viceré, A., Vidyant, S., Viets, A. D., Vijaykumar, A., Villa-Ortega, V., Vinet, J. -Y., Virtuoso, A., Vitale, S., Vo, T., Vocca, H., von Reis, E. R. G., von Wrangel, J. S. A., Vorvick, C., Vyatchanin, S. P., Wade, L. E., Wade, M., Wagner, K. J., Walet, R. C., Walker, M., Wallace, G. S., Wallace, L., Walsh, S., Wang, J., Wang, J. Z., Wang, W. H., Ward, R. L., Warner, J., Was, M., Washimi, T., Washington, N. Y., Watchi, J., Weaver, B., Webster, S. A., Weinert, M., Weinstein, A. J., Weiss, R., Weller, C. M., Wellmann, F., Wen, L., Weßels, P., Wette, K., Whelan, J. T., White, D. D., Whiting, B. F., Whittle, C., Wilken, D., Williams, D., Williams, M. J., Williamson, A. R., Willis, J. L., Willke, B., Wilson, D. J., Winkler, W., Wipf, C. C., Wlodarczyk, T., Woan, G., Woehler, J., Wofford, J. K., Wong, I. C. F., Wu, C., Wu, D. S., Wu, H., Wu, S., Wysocki, D. M., Xiao, L., Xu, W-R., Yamada, T., Yamamoto, H., Yamamoto, Kazuhiro, Yamamoto, Kohei, Yamamoto, T., Yamashita, K., Yamazaki, R., Yang, F. W., Yang, L., Yang, Y., Yang, Yang, Yang, Z., Yap, M. J., Yeeles, D. W., Yelikar, A. B., Ying, M., Yokogawa, K., Yokoyama, J., Yokozawa, T., Yoo, J., Yoshioka, T., Yu, Hang, Yu, Haocun, Yuzurihara, H., Zadrożny, A., Zanolin, M., Zeidler, S., Zelenova, T., Zendri, J. -P., Zevin, M., Zhan, M., Zhang, H., Zhang, J., Zhang, L., Zhang, T., Zhang, Y., Zhao, C., Zhao, G., Zhao, Y., Zhao, Yue, Zheng, Y., Zhou, R., Zhou, Z., Zhu, X. J., Zhu, Z. -H., Zimmerman, A. B., Zlochower, Y., Zucker, M. 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2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Kastler Brossel (LKB [Collège de France]), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des deux Infinis de Toulouse (L2IT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Observatoire de la Côte d'Azur (OCA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Est Marne-la-Vallée (UPEM), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), Institut des Hautes Études Scientifiques (IHES), IHES, LIGO Scientific, VIRGO, KAGRA, The LIGO Scientific Collaboration, the Virgo Collaboration, the KAGRA Collaboration, Laboratoire des matériaux avancés (LMA), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Kastler Brossel (LKB (Jussieu)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Navier (NAVIER UMR 8205), École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel, Centre Scientifique de Monaco (CSM), and Institut des Hautes Etudes Scientifiques (IHES)

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), [SDU]Sciences of the Universe [physics], [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - High Energy Astrophysical Phenomena, General Relativity and Quantum Cosmology
Abstract

We report on the population properties of 76 compact binary mergers detected with gravitational waves below a false alarm rate of 1 per year through GWTC-3. The catalog contains three classes of binary mergers: BBH, BNS, and NSBH mergers. We infer the BNS merger rate to be between 10 $\rm{Gpc^{-3} yr^{-1}}$ and 1700 $\rm{Gpc^{-3} yr^{-1}}$ and the NSBH merger rate to be between 7.8 $\rm{Gpc^{-3}\, yr^{-1}}$ and 140 $\rm{Gpc^{-3} yr^{-1}}$ , assuming a constant rate density versus comoving volume and taking the union of 90% credible intervals for methods used in this work. Accounting for the BBH merger rate to evolve with redshift, we find the BBH merger rate to be between 17.9 $\rm{Gpc^{-3}\, yr^{-1}}$ and 44 $\rm{Gpc^{-3}\, yr^{-1}}$ at a fiducial redshift (z=0.2). We obtain a broad neutron star mass distribution extending from $1.2^{+0.1}_{-0.2} M_\odot$ to $2.0^{+0.3}_{-0.3} M_\odot$. We can confidently identify a rapid decrease in merger rate versus component mass between neutron star-like masses and black-hole-like masses, but there is no evidence that the merger rate increases again before 10 $M_\odot$. We also find the BBH mass distribution has localized over- and under-densities relative to a power law distribution. While we continue to find the mass distribution of a binary's more massive component strongly decreases as a function of primary mass, we observe no evidence of a strongly suppressed merger rate above $\sim 60 M_\odot$. The rate of BBH mergers is observed to increase with redshift at a rate proportional to $(1+z)^{\kappa}$ with $\kappa = 2.9^{+1.7}_{-1.8}$ for $z\lesssim 1$. Observed black hole spins are small, with half of spin magnitudes below $\chi_i \simeq 0.25$. We observe evidence of negative aligned spins in the population, and an increase in spin magnitude for systems with more unequal mass ratio., Comment: v2: minor edits, most to Table 1 and caption; v3: rerun with public data; Data release: https://zenodo.org/record/5655785; v4: update Fig 14

Published
2021

38. S102: COMPREHENSIVE GENOME CHARACTERIZATION REVEALS NEW SUBTYPES AND MECHANISMS OF ONCOGENE DEREGULATION IN CHILDHOOD T-ALL

Author

Pölönen, P., primary, Elsayed, A., additional, Montefiori, L., additional, Kimura, S., additional, Myers, J., additional, Hedges, D., additional, Xu, J., additional, Hui, Y., additional, Cheng, Z., additional, Fan, Y., additional, Chang, Y., additional, Shraim, R., additional, Devidas, M., additional, Winter, S., additional, Dunsmore, K., additional, Yang, J. J., additional, Vincent, T. L., additional, Tan, K., additional, Chen, C., additional, Newman, H., additional, Loh, M., additional, Raetz, E., additional, Hunger, S. P., additional, Rampersaud, E., additional, Chang, T.-C., additional, Wu, G., additional, Pounds, S., additional, Mullighan, C. G., additional, and Teachey, D. T., additional

Published
2022
Full Text
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39. PB1763: A PHASE 1/2 STUDY TO EVALUATE PONATINIB WITH CHEMOTHERAPY IN PEDIATRIC PATIENTS WITH RELAPSED/RESISTANT/INTOLERANT PHILADELPHIA CHROMOSOME–POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA OR WITH T315I MUTATION

Author

Gore, L., primary, Loh, M., additional, Pui, C.-H., additional, Matloub, Y., additional, Hanley, M. J., additional, Du, J., additional, Hennessy, M., additional, Granier, M., additional, Biondi, A., additional, and Silverman, L., additional

Published
2022
Full Text
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40. Applying the exposome concept to working life health:The EU EPHOR project

Author

Pronk, A, Loh, M, Kuijpers, E, Albin, M, Selander, J, Godderis, L, Ghosh, M, Vermeulen, R, Peters, S, Mehlum, IS, Turner, MC, Schlünssen, V, Goldberg, M, Kogevinas, M, Harding, BN, Solovieva, S, Garani-Papadatos, T, van Tongeren, M, The EPHOR Consortium, and Stierum, R

Subjects
Global and Planetary Change, Exposome, Health, Epidemiology, Health, Toxicology and Mutagenesis, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, Toxicology and Mutagenesis, Noncommunicable disease, Public Health, Pollution, Occupational, Working life
Abstract

Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all occupational and related nonoccupational exposures. The latter includes nonoccupational exposures that may be directly or indirectly influenced by or interact with the working life of the individual in their relation to health. The Exposome Project for Health and Occupational Research aims to advance knowledge on the complex working life exposures in relation to disease beyond the single high exposure–single health outcome paradigm, mapping and relating interrelated exposures to inherent biological pathways, key body functions, and health. This will be achieved by combining (1) large-scale harmonization and pooling of existing European cohorts systematically looking at multiple exposures and diseases, with (2) the collection of new high-resolution external and internal exposure data. Methods and tools to characterize the working life exposome will be developed and applied, including sensors, wearables, a harmonized job exposure matrix (EuroJEM), noninvasive biomonitoring, omics, data mining, and (bio)statistics. The toolbox of developed methods and knowledge will be made available to policy makers, occupational health practitioners, and scientists. Advanced knowledge on working life exposures in relation to NCDs will serve as a basis for evidence-based and cost-effective preventive policies and actions. The toolbox will also enable future scientists to further expand the working life exposome knowledge base. ispartof: Environmental Epidemiology vol:6 issue:2 ispartof: location:United States status: Published online

Published
2022

41. Molecular characterisation and clinical outcome of B-cell precursor acute lymphoblastic leukaemia with IG-MYC rearrangement

Author

Bomken, S, Enshaei, A, Schwalbe, E, Mikulasova, A, Dai, Y, Zaka, M, Fung, K, Bashton, M, Lim, H, Jones, L, Karataraki, N, Winterman, E, Ashby, C, Attarbaschi, A, Bertrand, Y, Bradtke, J, Buldini, B, Burke, G, Cazzaniga, G, Gohring, G, De Groot-Kruseman, H, Haferlach, C, Nigro, L, Parihar, M, Plesa, A, Seaford, E, Sonneveld, E, Strehl, S, Van der Velden, V, Rand, V, Hunger, S, Harrison, C, Bacon, C, Van Delft, F, Loh, M, Moppett, J, Vormoor, J, Walker, B, Moorman, A, Russell, L, Bomken, Simon, Enshaei, Amir, Schwalbe, Edward C, Mikulasova, Aneta, Dai, Yunfeng, Zaka, Masood, Fung, Kent Tm, Bashton, Matthew, Lim, Huezin, Jones, Lisa, Karataraki, Nefeli, Winterman, Emily, Ashby, Cody, Attarbaschi, Andishe, Bertrand, Yves, Bradtke, Jutta, Buldini, Barbara, Burke, G. A. Amos, Cazzaniga, Giovanni, Gohring, Gudrun, De Groot-Kruseman, Hesta A, Haferlach, Claudia, Nigro, Luca Lo, Parihar, Mayur, Plesa, Adriana, Seaford, Emma, Sonneveld, Edwin, Strehl, Sabine, Van der Velden, Vincent Hj, Rand, Vikki, Hunger, Stephen P, Harrison, Christine J, Bacon, Chris M, Van Delft, Frederik W, Loh, Mignon L, Moppett, John, Vormoor, Josef, Walker, Brian A, Moorman, Anthony V, Russell, Lisa J, Bomken, S, Enshaei, A, Schwalbe, E, Mikulasova, A, Dai, Y, Zaka, M, Fung, K, Bashton, M, Lim, H, Jones, L, Karataraki, N, Winterman, E, Ashby, C, Attarbaschi, A, Bertrand, Y, Bradtke, J, Buldini, B, Burke, G, Cazzaniga, G, Gohring, G, De Groot-Kruseman, H, Haferlach, C, Nigro, L, Parihar, M, Plesa, A, Seaford, E, Sonneveld, E, Strehl, S, Van der Velden, V, Rand, V, Hunger, S, Harrison, C, Bacon, C, Van Delft, F, Loh, M, Moppett, J, Vormoor, J, Walker, B, Moorman, A, Russell, L, Bomken, Simon, Enshaei, Amir, Schwalbe, Edward C, Mikulasova, Aneta, Dai, Yunfeng, Zaka, Masood, Fung, Kent Tm, Bashton, Matthew, Lim, Huezin, Jones, Lisa, Karataraki, Nefeli, Winterman, Emily, Ashby, Cody, Attarbaschi, Andishe, Bertrand, Yves, Bradtke, Jutta, Buldini, Barbara, Burke, G. A. Amos, Cazzaniga, Giovanni, Gohring, Gudrun, De Groot-Kruseman, Hesta A, Haferlach, Claudia, Nigro, Luca Lo, Parihar, Mayur, Plesa, Adriana, Seaford, Emma, Sonneveld, Edwin, Strehl, Sabine, Van der Velden, Vincent Hj, Rand, Vikki, Hunger, Stephen P, Harrison, Christine J, Bacon, Chris M, Van Delft, Frederik W, Loh, Mignon L, Moppett, John, Vormoor, Josef, Walker, Brian A, Moorman, Anthony V, and Russell, Lisa J

Abstract

Rarely, immunophenotypically immature B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) carries an immunoglobulin-MYC rearrangement (IG-MYC-r). This can result in diagnostic confusion with Burkitt lymphoma/leukaemia and use of unproven individualised treatment schedules. Here we contrast the molecular characteristics of these conditions and investigate historic clinical outcome data. We identified 90 cases registered on a national BCP-ALL clinical trial/registry. Where present, diagnostic material underwent cytogenetic, exome, methylome and transcriptome analysis. Outcome was analysed to define 3-year event free survival (EFS) and overall survival (OS). IG-MYC-r was identified in diverse cytogenetic backgrounds, co-existing with either: established BCP-ALL specific abnormalities (high hyperdiploidy n=3, KMT2A-rearrangement n=6, iAMP21 n=1, BCR-ABL n=1); BCL2/BCL6-rearrangements (n=15); or, most commonly, as the only defining feature (n=64). Within this final group, precursor-like V(D)J breakpoints predominated (8/9) and KRAS mutations were common (5/11). DNA methylation identified a cluster of V(D)J rearranged cases, clearly distinct from Burkitt leukaemia/lymphoma. Children with IG-MYC-r within that subgroup had 3-year EFS of 47% and OS of 60%, representing a high-risk BCP-ALL. To develop effective management strategies this patient group must be allowed access to contemporary, minimal residual disease adapted, prospective clinical trial protocols.

Published
2022

42. Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.

Author

Loh, M, Zhang, W, Ng, HK, Schmid, K, Lamri, A, Tong, L, Ahmad, M, Lee, J-J, Ng, MCY, Petty, LE, Spracklen, CN, Takeuchi, F, Islam, MT, Jasmine, F, Kasturiratne, A, Kibriya, M, Mohlke, KL, Paré, G, Prasad, G, Shahriar, M, Chee, ML, de Silva, HJ, Engert, JC, Gerstein, HC, Mani, KR, Sabanayagam, C, Vujkovic, M, Wickremasinghe, AR, Wong, TY, Yajnik, CS, Yusuf, S, Ahsan, H, Bharadwaj, D, Anand, SS, Below, JE, Boehnke, M, Bowden, DW, Chandak, GR, Cheng, C-Y, Kato, N, Mahajan, A, Sim, X, McCarthy, MI, Morris, AP, Kooner, JS, Saleheen, D, Chambers, JC, Loh, M, Zhang, W, Ng, HK, Schmid, K, Lamri, A, Tong, L, Ahmad, M, Lee, J-J, Ng, MCY, Petty, LE, Spracklen, CN, Takeuchi, F, Islam, MT, Jasmine, F, Kasturiratne, A, Kibriya, M, Mohlke, KL, Paré, G, Prasad, G, Shahriar, M, Chee, ML, de Silva, HJ, Engert, JC, Gerstein, HC, Mani, KR, Sabanayagam, C, Vujkovic, M, Wickremasinghe, AR, Wong, TY, Yajnik, CS, Yusuf, S, Ahsan, H, Bharadwaj, D, Anand, SS, Below, JE, Boehnke, M, Bowden, DW, Chandak, GR, Cheng, C-Y, Kato, N, Mahajan, A, Sim, X, McCarthy, MI, Morris, AP, Kooner, JS, Saleheen, D, and Chambers, JC

Abstract

South Asians are at high risk of developing type 2 diabetes (T2D). We carried out a genome-wide association meta-analysis with South Asian T2D cases (n = 16,677) and controls (n = 33,856), followed by combined analyses with Europeans (neff = 231,420). We identify 21 novel genetic loci for significant association with T2D (P = 4.7 × 10-8 to 5.2 × 10-12), to the best of our knowledge at the point of analysis. The loci are enriched for regulatory features, including DNA methylation and gene expression in relevant tissues, and highlight CHMP4B, PDHB, LRIG1 and other genes linked to adiposity and glucose metabolism. A polygenic risk score based on South Asian-derived summary statistics shows ~4-fold higher risk for T2D between the top and bottom quartile. Our results provide further insights into the genetic mechanisms underlying T2D, and highlight the opportunities for discovery from joint analysis of data from across ancestral populations.

Published
2022

43. Author Correction: Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.

Author

Loh, M, Zhang, W, Ng, HK, Schmid, K, Lamri, A, Tong, L, Ahmad, M, Lee, J-J, Ng, MCY, Petty, LE, Spracklen, CN, Takeuchi, F, Islam, MT, Jasmine, F, Kasturiratne, A, Kibriya, M, Mohlke, KL, Paré, G, Prasad, G, Shahriar, M, Chee, ML, de Silva, HJ, Engert, JC, Gerstein, HC, Mani, KR, Sabanayagam, C, Vujkovic, M, Wickremasinghe, AR, Wong, TY, Yajnik, CS, Yusuf, S, Ahsan, H, Bharadwaj, D, Anand, SS, Below, JE, Boehnke, M, Bowden, DW, Chandak, GR, Cheng, C-Y, Kato, N, Mahajan, A, Sim, X, McCarthy, MI, Morris, AP, Kooner, JS, Saleheen, D, Chambers, JC, Loh, M, Zhang, W, Ng, HK, Schmid, K, Lamri, A, Tong, L, Ahmad, M, Lee, J-J, Ng, MCY, Petty, LE, Spracklen, CN, Takeuchi, F, Islam, MT, Jasmine, F, Kasturiratne, A, Kibriya, M, Mohlke, KL, Paré, G, Prasad, G, Shahriar, M, Chee, ML, de Silva, HJ, Engert, JC, Gerstein, HC, Mani, KR, Sabanayagam, C, Vujkovic, M, Wickremasinghe, AR, Wong, TY, Yajnik, CS, Yusuf, S, Ahsan, H, Bharadwaj, D, Anand, SS, Below, JE, Boehnke, M, Bowden, DW, Chandak, GR, Cheng, C-Y, Kato, N, Mahajan, A, Sim, X, McCarthy, MI, Morris, AP, Kooner, JS, Saleheen, D, and Chambers, JC

Published
2022

44. The iHealth-T2D study:a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: a statistical analysis plan

Author

Muilwijk, M. (Mirthe), Loh, M. (Marie), Mahmood, S. (Sara), Palaniswamy, S. (Saranya), Siddiqui, S. (Samreen), Silva, W. (Wnurinham), Frost, G. S. (Gary S.), Gage, H. M. (Heather M.), Järvelin, M.-R. (Marjo-Riitta), Rannan-Eliya, R. P. (Ravindra P.), Ahmad, S. (Sajjad), Jha, S. (Sujeet), Kasturiratne, A. (Anuradhani), Katulanda, P. (Prasad), Khawaja, K. I. (Khadija I.), Kooner, J. S. (Jaspal S.), Wickremasinghe, A. R. (Ananda R.), van Valkengoed, I. G. (Irene G. M.), Chambers, J. C. (John C.), Muilwijk, M. (Mirthe), Loh, M. (Marie), Mahmood, S. (Sara), Palaniswamy, S. (Saranya), Siddiqui, S. (Samreen), Silva, W. (Wnurinham), Frost, G. S. (Gary S.), Gage, H. M. (Heather M.), Järvelin, M.-R. (Marjo-Riitta), Rannan-Eliya, R. P. (Ravindra P.), Ahmad, S. (Sajjad), Jha, S. (Sujeet), Kasturiratne, A. (Anuradhani), Katulanda, P. (Prasad), Khawaja, K. I. (Khadija I.), Kooner, J. S. (Jaspal S.), Wickremasinghe, A. R. (Ananda R.), van Valkengoed, I. G. (Irene G. M.), and Chambers, J. C. (John C.)

Abstract

Background: South Asians are at high risk of type 2 diabetes (T2D). Lifestyle modification is effective at preventing T2D amongst South Asians, but the approaches to screening and intervention are limited by high costs, poor scalability and thus low impact on T2D burden. An intensive family-based lifestyle modification programme for the prevention of T2D was developed. The aim of the iHealth-T2D trial is to compare the effectiveness of this programme with usual care. Methods: The iHealth-T2D trial is designed as a cluster randomised controlled trial (RCT) conducted at 120 sites across India, Pakistan, Sri Lanka and the UK. A total of 3682 South Asian men and women with age between 40 and 70 years without T2D but at elevated risk for T2D [defined by central obesity (waist circumference ≥ 95 cm in Sri Lanka or ≥ 100 cm in India, Pakistan and the UK) and/or prediabetes (HbA1c ≥ 6.0%)] were included in the trial. Here, we describe in detail the statistical analysis plan (SAP), which was finalised before outcomes were available to the investigators. The primary outcome will be evaluated after 3 years of follow-up after enrolment to the study and is defined as T2D incidence in the intervention arm compared to usual care. Secondary outcomes are evaluated both after 1 and 3 years of follow-up and include biochemical measurements, anthropometric measurements, behavioural components and treatment compliance. Discussion: The iHealth-T2D trial will provide evidence of whether an intensive family-based lifestyle modification programme for South Asians who are at high risk for T2D is effective in the prevention of T2D. The data from the trial will be analysed according to this pre-specified SAP. Ethics and dissemination: The trial was approved by the international review board of each participating study site. Study findings will be disseminated through peer-reviewed publications and in conference presentations. Trial registration: EudraCT 2016–001,350-18. Registered on

Published
2022

45. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Author

Wielscher, M. (Matthias), Mandaviya, P. R. (Pooja R.), Kuehnel, B. (Brigitte), Joehanes, R. (Roby), Mustafa, R. (Rima), Robinson, O. (Oliver), Zhang, Y. (Yan), Bodinier, B. (Barbara), Walton, E. (Esther), Mishra, P. P. (Pashupati P.), Schlosser, P. (Pascal), Wilson, R. (Rory), Tsai, P.-C. (Pei-Chien), Palaniswamy, S. (Saranya), Marioni, R. E. (Riccardo E.), Fiorito, G. (Giovanni), Cugliari, G. (Giovanni), Karhunen, V. (Ville), Ghanbari, M. (Mohsen), Psaty, B. M. (Bruce M.), Loh, M. (Marie), Bis, J. C. (Joshua C.), Lehne, B. (Benjamin), Sotoodehnia, N. (Nona), Deary, I. J. (Ian J.), Chadeau-Hyam, M. (Marc), Brody, J. A. (Jennifer A.), Cardona, A. (Alexia), Selvin, E. (Elizabeth), Smith, A. K. (Alicia K.), Miller, A. H. (Andrew H.), Torres, M. A. (Mylin A.), Marouli, E. (Eirini), Gao, X. (Xin), van Meurs, J. B. (Joyce B. J.), Graf-Schindler, J. (Johanna), Rathmann, W. (Wolfgang), Koenig, W. (Wolfgang), Peters, A. (Annette), Weninger, W. (Wolfgang), Farlik, M. (Matthias), Zhang, T. (Tao), Chen, W. (Wei), Xia, Y. (Yujing), Teumer, A. (Alexander), Nauck, M. (Matthias), Grabe, H. J. (Hans J.), Doerr, M. (Macus), Lehtimaki, T. (Terho), Guan, W. (Weihua), Milani, L. (Lili), Tanaka, T. (Toshiko), Fisher, K. (Krista), Waite, L. L. (Lindsay L.), Kasela, S. (Silva), Vineis, P. (Paolo), Verweij, N. (Niek), van der Harst, P. (Pim), Iacoviello, L. (Licia), Sacerdote, C. (Carlotta), Panico, S. (Salvatore), Krogh, V. (Vittorio), Tumino, R. (Rosario), Tzala, E. (Evangelia), Matullo, G. (Giuseppe), Hurme, M. A. (Mikko A.), Raitakari, O. T. (Olli T.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Kahonen, M. (Mika), Herzig, K.-H. (Karl-Heinz), Li, S. (Shengxu), BIOS consortium, Conneely, K. N. (Karen N.), Kooner, J. S. (Jaspal S.), Kottgen, A. (Anna), Heijmans, B. T. (Bastiaan T.), Deloukas, P. (Panos), Relton, C. (Caroline), Ong, K. K. (Ken K.), Bell, J. T. (Jordana T.), Boerwinkle, E. (Eric), Elliott, P. (Paul), Brenner, H. (Hermann), Beekman, M. (Marian), Levy, D. (Daniel), Waldenberger, M. (Melanie), Chambers, J. C. (John C.), Dehghan, A. (Abbas), Järvelin, M.-R. (Marjo-Riitta), Wielscher, M. (Matthias), Mandaviya, P. R. (Pooja R.), Kuehnel, B. (Brigitte), Joehanes, R. (Roby), Mustafa, R. (Rima), Robinson, O. (Oliver), Zhang, Y. (Yan), Bodinier, B. (Barbara), Walton, E. (Esther), Mishra, P. P. (Pashupati P.), Schlosser, P. (Pascal), Wilson, R. (Rory), Tsai, P.-C. (Pei-Chien), Palaniswamy, S. (Saranya), Marioni, R. E. (Riccardo E.), Fiorito, G. (Giovanni), Cugliari, G. (Giovanni), Karhunen, V. (Ville), Ghanbari, M. (Mohsen), Psaty, B. M. (Bruce M.), Loh, M. (Marie), Bis, J. C. (Joshua C.), Lehne, B. (Benjamin), Sotoodehnia, N. (Nona), Deary, I. J. (Ian J.), Chadeau-Hyam, M. (Marc), Brody, J. A. (Jennifer A.), Cardona, A. (Alexia), Selvin, E. (Elizabeth), Smith, A. K. (Alicia K.), Miller, A. H. (Andrew H.), Torres, M. A. (Mylin A.), Marouli, E. (Eirini), Gao, X. (Xin), van Meurs, J. B. (Joyce B. J.), Graf-Schindler, J. (Johanna), Rathmann, W. (Wolfgang), Koenig, W. (Wolfgang), Peters, A. (Annette), Weninger, W. (Wolfgang), Farlik, M. (Matthias), Zhang, T. (Tao), Chen, W. (Wei), Xia, Y. (Yujing), Teumer, A. (Alexander), Nauck, M. (Matthias), Grabe, H. J. (Hans J.), Doerr, M. (Macus), Lehtimaki, T. (Terho), Guan, W. (Weihua), Milani, L. (Lili), Tanaka, T. (Toshiko), Fisher, K. (Krista), Waite, L. L. (Lindsay L.), Kasela, S. (Silva), Vineis, P. (Paolo), Verweij, N. (Niek), van der Harst, P. (Pim), Iacoviello, L. (Licia), Sacerdote, C. (Carlotta), Panico, S. (Salvatore), Krogh, V. (Vittorio), Tumino, R. (Rosario), Tzala, E. (Evangelia), Matullo, G. (Giuseppe), Hurme, M. A. (Mikko A.), Raitakari, O. T. (Olli T.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Kahonen, M. (Mika), Herzig, K.-H. (Karl-Heinz), Li, S. (Shengxu), BIOS consortium, Conneely, K. N. (Karen N.), Kooner, J. S. (Jaspal S.), Kottgen, A. (Anna), Heijmans, B. T. (Bastiaan T.), Deloukas, P. (Panos), Relton, C. (Caroline), Ong, K. K. (Ken K.), Bell, J. T. (Jordana T.), Boerwinkle, E. (Eric), Elliott, P. (Paul), Brenner, H. (Hermann), Beekman, M. (Marian), Levy, D. (Daniel), Waldenberger, M. (Melanie), Chambers, J. C. (John C.), Dehghan, A. (Abbas), and Järvelin, M.-R. (Marjo-Riitta)

Abstract

We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions. Mendelian randomization analysis suggests altered CpG methylation is a consequence of increased blood CRP levels. Mediation analysis reveals obesity and smoking as important underlying driving factors for changed CpG methylation. Finally, we find that an activated CpG signature significantly increases the risk for cardiometabolic diseases and COPD.

Published
2022

46. Quantification of biocatalytic transformations by single microbial cells enabled by tailored integration of droplet microfluidics and mass spectrometry

Author

Wink, K., van der Loh, M., Hartner, N., Polack, M., Dusny, Christian, Schmid, Andreas, Belder, D., Wink, K., van der Loh, M., Hartner, N., Polack, M., Dusny, Christian, Schmid, Andreas, and Belder, D.

Abstract

Improving the performance of chemical transformations catalysed by microbial biocatalysts requires a deep understanding of cellular processes. While the cellular heterogeneity of cellular characteristics, such as the concentration of high abundant cellular content, is well studied, little is known about the reactivity of individual cells and its impact on the chemical identity, quantity, and purity of excreted products. Biocatalytic transformations were monitored chemically specific and quantifiable at the single-cell level by integrating droplet microfluidics, cell imaging, and mass spectrometry. Product formation rates for individual Saccharomyces cerevisiae cells were obtained by i) incubating nanolitre-sized droplets for product accumulation in microfluidic devices, ii) an imaging setup to determine the number of cells in the droplets, and iii) electrospray ionisation mass spectrometry for reading the chemical contents of individual droplets. These findings now enable the study of whole-cell biocatalysis at single-cell resolution.

Published
2022

47. Remission, treatment failure, and relapse in pediatric ALL: an international consensus of the Ponte-di-Legno Consortium

Author

Buchmann, S., Schrappe, M., Baruchel, A., Biondi, A., Borowitz, M., Campbell, M., Cario, G., Cazzaniga, G., Escherich, G., Harrison, C. J., Heyman, M., Hunger, S. P., Kiss, C., Liu, H. -C., Locatelli, Franco, Loh, M. L., Manabe, A., Mann, G., Pieters, R., Pui, C. -H., Rives, S., Schmiegelow, K., Silverman, L. B., Stary, J., Vora, A., Brown, P., Locatelli F. (ORCID:0000-0002-7976-3654), Buchmann, S., Schrappe, M., Baruchel, A., Biondi, A., Borowitz, M., Campbell, M., Cario, G., Cazzaniga, G., Escherich, G., Harrison, C. J., Heyman, M., Hunger, S. P., Kiss, C., Liu, H. -C., Locatelli, Franco, Loh, M. L., Manabe, A., Mann, G., Pieters, R., Pui, C. -H., Rives, S., Schmiegelow, K., Silverman, L. B., Stary, J., Vora, A., Brown, P., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Comparison of treatment strategies in de novo pediatric acute lymphoblastic leukemia (ALL) requires standardized measures of efficacy. Key parameters that define disease-related events, including complete remission (CR), treatment failure (TF; not achieving CR), and relapse (loss of CR) require an updated consensus incorporating modern diagnostics. We collected the definitions of CR, TF, and relapse from recent and current pediatric clinical trials for the treatment of ALL, including the key components of response evaluation (timing, anatomic sites, detection methods, and thresholds) and found significant heterogeneity, most notably in the definition of TF. Representatives of the major international ALL clinical trial groups convened to establish consensus definitions. CR should be defined at a time point no earlier than at the end of induction and should include the reduction of blasts below a specific threshold in bone marrow and extramedullary sites, incorporating minimal residual disease (MRD) techniques for marrow evaluations. TF should be defined as failure to achieve CR by a prespecified time point in therapy. Relapse can only be defined in patients who have achieved CR and must include a specific threshold of leukemic cells in the bone marrow confirmed by MRD, the detection of central nervous system leukemia, or documentation of extramedullary disease. Definitions of TF and relapse should harmonize with eligibility criteria for clinical trials in relapsed/refractory ALL. These consensus definitions will enhance the ability to compare outcomes across pediatric ALL trials and facilitate development of future international collaborative trials.

Published
2022

50. Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

Author

McAllan, L., primary, Baranasic, D., additional, Villicaña, S., additional, Zhang, W., additional, Lehne, B., additional, Adamo, M., additional, Jenkinson, A., additional, Elkalaawy, M., additional, Mohammadi, B., additional, Hashemi, M., additional, Yang, Y., additional, Zudina, L., additional, Lagou, V., additional, Tan, S., additional, Castillo-Fernandez, J., additional, Soong, R., additional, Elliott, P., additional, Scott, J., additional, Loh, M., additional, Prokopenko, I., additional, Lenhard, B., additional, Batterham, R. L., additional, Bell, J., additional, Chambers, J., additional, Kooner, J., additional, and Scott, W., additional

Published
2021
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