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2. Nightfall.

Author

Logan, Kirsty

Subjects
SCHOOL restrooms, CARPAL bones, NIGHT terrors, LATEX gloves, SCHOOL day, KISSING, HAND washing, DESKS
Abstract

"Nightfall" by Kirsty Logan is a provocative and introspective narrative that delves into themes of desire, power, and self-harm. The protagonist grapples with complex emotions and experiences, including menstruation, self-inflicted wounds, and a mysterious, intimate connection with a supernatural entity. Through vivid imagery and raw storytelling, the text explores the protagonist's journey towards self-discovery and acceptance, culminating in a poignant reflection on love, loss, and the enduring scars of the past. [Extracted from the article]

Published
2024

3. Association of frequent moisturizer use in early infancy with the development of food allergy

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Byrom, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Turcanu, Victor, Perkin, Michael R., Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Craven, Joanna, Boyle, Robert J., Chalmers, Joanne R., Williams, Hywel C., Versteeg, Serge A., van Ree, Ronald, Lack, Gideon, and Flohr, Carsten

Published
2021
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5. Biomarkers of peanut allergy in children over time.

Author

Foong, Ru‐Xin, Du Toit, George, van Ree, Ronald, Bahnson, Henry T., Radulovic, Suzana, Craven, Jo, Kwok, Matthew, Jama, Zainab, Versteeg, Serge A., Brough, Helen A., Logan, Kirsty, Perkin, Michael R., Flohr, Carsten, Lack, Gideon, and Santos, Alexandra F.

Subjects
PEANUT allergy, MAST cells, FOOD allergy, CELL anatomy, SKIN tests
Abstract

Background: Various biomarkers are used to define peanut allergy (PA). We aimed to observe changes in PA resolution and persistence over time comparing biomarkers in PA and peanut sensitised but tolerant (PS) children in a population‐based cohort. Methods: Participants were recruited from the EAT and EAT‐On studies, conducted across England and Wales, and were exclusively breastfeed babies recruited at 3 months old and followed up until 7–12 years old. Clinical characteristics, skin prick test (SPT), sIgE to peanut and peanut components and mast cell activation tests (MAT) were assessed at 12 months, 36 months and 7–12 years. PA status was determined at the 7–12 year time point. Results: The prevalence of PA was 2.1% at 7–12 years. Between 3 and 7–12 year, two children developed PA and one outgrew PA. PA children had larger SPT, higher peanut‐sIgE, Ara h 2‐sIgE and MAT (all p <.001) compared to PS children from 12 months onwards. SPT, peanut‐sIgE, Ara h 2‐sIgE and MAT between children with persistent PA, new PA, outgrown PA and PS were statistically significant from 12 months onwards (p <.001). Those with persistent PA had SPT, peanut‐sIgE and Ara h 2‐sIgE that increased over time and MAT which was highest at 36 months. New PA children had increased SPT and peanut‐sIgE from 36 months to 7–12 years, but MAT remained low. PS children had low biomarkers across time. Conclusions: In this cohort, few children outgrow or develop new PA between 36 months and 7–12 years. Children with persistent PA have raised SPT, peanut‐sIgE, Ara h 2‐sIgE and MAT evident from infancy that consistently increase over time. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Challenges experienced with early introduction and sustained consumption of allergenic foods in the Enquiring About Tolerance (EAT) study: A qualitative analysis

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Byrom, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Turcanu, Victor, Voorheis, Paula, Bell, Sadie, Cornelsen, Laura, Quaife, Matthew, Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Craven, Joanna, Flohr, Carsten, Lack, Gideon, and Perkin, Michael R.

Published
2019
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7. Factors influencing adherence in a trial of early introduction of allergenic food

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Byrom, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Perkin, Michael R., Bahnson, Henry T., Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Knibb, Rebecca, Craven, Joanna, Flohr, Carsten, Mills, E.N., Versteeg, Serge A., van Ree, Ronald, and Lack, Gideon

Published
2019
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8. Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Byrom, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Turcanu, Victor, Perkin, Michael R., Logan, Kirsty, Bahnson, Henry T., Marrs, Tom, Radulovic, Suzana, Craven, Joanna, Flohr, Carsten, Mills, E.N., Versteeg, Serge A., van Ree, Ronald, and Lack, Gideon

Published
2019
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10. Biomarkers to predict changes in peanut allergy in children over time

Author

Foong, Ru-Xin, primary, Toit, George Du, additional, Ree, Ronald Van, additional, H, Tee Bahnson, additional, Radulovic, Suzana, additional, Craven, Jo, additional, Kwok, Matthew, additional, Jama, Zainab, additional, S.A., Versteeg, additional, Brough, Helen A., additional, Logan, Kirsty, additional, Perkin, Michael, additional, Flohr, Carsten, additional, Lack, Gideon, additional, and Santos, Alexandra, additional

Published
2023
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12. Association between domestic water hardness, chlorine, and atopic dermatitis risk in early life: A population-based cross-sectional study

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Nesbeth, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Turcanu, Victor, Perkin, Michael R., Craven, Joanna, Logan, Kirsty, Strachan, David, Marrs, Tom, Radulovic, Suzana, Campbell, Linda E., MacCallum, Stephanie F., McLean, W.H. Irwin, Lack, Gideon, and Flohr, Carsten

Published
2016
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13. Enquiring About Tolerance (EAT) study: Feasibility of an early allergenic food introduction regimen

Author

Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Nesbeth, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, Tonner, Sharon, Banks, Emily, Kahnum, Yasmin, Babic, Rachel, Stockwell, Ben, Thompson, Erin, Wheatley, Lorna, Patkunam, Devi, Richards, Kerry, Pietraszewicz, Ewa, Stephens, Alick, Sudra, Asha, Turcanu, Victor, Perkin, Michael R., Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Craven, Joanna, Flohr, Carsten, and Lack, Gideon

Published
2016
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19. Modifying the infantʼs diet to prevent food allergy

Author

Grimshaw, Kate, Logan, Kirsty, OʼDonovan, Sinead, Kiely, Mairead, Patient, Karine, van Bilsen, Jolanda, Beyer, Kirsten, Campbell, Dianne E, Garcia-Larsen, Vanessa, Grabenhenrich, Linus, Lack, Gideon, Mills, Clare, Wal, Jean-Michel, and Roberts, Graham

Published
2017
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20. Early introduction of peanut reduces peanut allergy across risk groups in pooled and causal inference analyses.

Author

Logan, Kirsty, Bahnson, Henry T., Ylescupidez, Alyssa, Beyer, Kirsten, Bellach, Johanna, Campbell, Dianne E., Craven, Joanna, Du Toit, George, Clare Mills, E. N., Perkin, Michael R., Roberts, Graham, van Ree, Ronald, and Lack, Gideon

Subjects
*PEANUT allergy, *CAUSAL inference, *PEANUTS, *CHILD patients, *RISK assessment
Abstract

Background: The Learning Early About Peanut allergy (LEAP) study has shown the effectiveness of early peanut introduction in prevention of peanut allergy (PA). In the Enquiring About Tolerance (EAT) study, a statistically significant reduction in PA was present only in per‐protocol (PP) analyses, which can be subject to bias. Objective: The aim of this study was to combine individual‐level data from the LEAP and EAT trials and provide robust evidence on the bias‐corrected, causal effect of early peanut introduction. Method: As part of the European Union‐funded iFAAM project, this pooled analysis of individual pediatric patient data combines and compares effectiveness and efficacy estimates of oral tolerance induction among different risk strata and analysis methods. Results: An intention‐to‐treat (ITT) analysis of pooled data showed a 75% reduction in PA (p <.0001) among children randomized to consume peanut from early infancy. A protective effect was present across all eczema severity groups, irrespective of enrollment sensitization to peanut, and across different ethnicities. Earlier age of introduction was associated with improved effectiveness of the intervention. In the pooled PP analysis, peanut consumption reduced the risk of PA by 98% (p <.0001). A causal inference analysis confirmed the strong PP effect (89% average treatment effect relative risk reduction p <.0001). A multivariable causal inference analysis approach estimated a large (100%) reduction in PA in children without eczema (p =.004). Conclusion: We demonstrate a significant reduction in PA with early peanut introduction in a large group of pooled, randomized participants. This significant reduction was demonstrated across all risk subgroups, including children with no eczema. Furthermore, our results point to increased efficacy of the intervention with earlier age of introduction. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Association of frequent moisturizer use in early infancy with the development of food allergy

Author

Perkin, Michael R., Logan, Kirsty, Marrs, Tom, Radulovic, Suzana, Craven, Joanna, Boyle, Robert J., Chalmers, Joanne R., Williams, Hywel C., Versteeg, Serge A., Van Ree, Ronald, Lack, Gideon, and Flohr, Carsten

Abstract

BackgroundFood allergy is thought to develop through transcutaneous sensitization, especially in the presence of skin barrier impairment and inflammation. Regular moisturizer application to infant skin could potentially promote transcutaneous sensitization and the development of food allergy.ObjectivesWe tested this hypothesis in the Enquiring About Tolerance (EAT) study population.MethodsThe EAT study was a population-based randomized clinical trial conducted from January 15, 2008, to August 31, 2015, and recruited 1303 exclusively breastfed 3-month-old infants and their families from England and Wales. At enrollment at 3 months, families completed a questionnaire that included questions about frequency and type of moisturizer applied, use of corticosteroid creams, and parental report of dry skin or eczema. Infants were examined for visible eczema at the enrollment visit.ResultsA statistically significant dose-response relationship was observed between parent-reported moisturization frequency at 3 months of age and the subsequent development of food allergy. Each additional moisturization per week was associated with an adjusted odds ratio of 1.20 (95% CI, 1.13-1.27; P [less than].0005) for developing food allergy. For infants with no visible eczema at the enrollment visit, the corresponding adjusted odds ratio was 1.18 (95% CI, 1.07-1.30; P = .001) and for those with eczema at the enrollment visit, 1.20 (95% CI, 1.11-1.31; P [less than] .0005). Moisturizer frequency showed similar dose-response relationships with the development of both food and aeroallergen sensitization at 36 months.ConclusionsThese findings support the notion that regular application of moisturizers to the skin of young infants may promote the development of food allergy through transcutaneous sensitization.

Published
2021

31. Frequency of guideline‐defined cow's milk allergy symptoms in infants: Secondary analysis of EAT trial data.

Author

Vincent, Rosie, MacNeill, Stephanie J., Marrs, Tom, Craven, Joanna, Logan, Kirsty, Flohr, Carsten, Lack, Gideon, Radulovic, Suzana, Perkin, Michael R., and Ridd, Matthew J.

Subjects
MILK allergy, SECONDARY analysis, INFANTS
Abstract

Background: Non‐IgE‐mediated Cow's Milk Allergy (CMA) has a prevalence of less than 1% in children. Guidelines developed to help non‐specialists diagnose CMA may lead to misattribution of normal symptoms and contribute to overdiagnosis of CMA. We sought to establish the frequency of symptoms during infancy associated with non‐IgE‐mediated CMA, using the international Milk Allergy in Primary Care (iMAP) guideline as representative of CMA guidelines more generally. Method: Secondary analysis of the Enquiring About Tolerance (EAT) randomized controlled trial (ISRCTN 14254740; 1303 exclusively breastfed 3‐month‐old healthy infants). Key outcomes were ≥2 iMAP symptoms associated with 'mild‐moderate' and 'severe' non‐IgE‐mediated CMA. Results: Whilst breastfeeding and parental atopy rates were higher than the general population, participants were otherwise similar to the population of England and Wales. Two or more non‐IgE CMA symptoms were reported by 25% families for mild‐moderate and 1.4% for severe symptoms each month between ages 3 and 12 months, peaking at 38% with ≥2 mild‐moderate and 4.3% ≥2 severe symptoms at three months, when participants were not directly consuming cow's milk. 74% of participants reported ≥2 mild‐moderate symptoms and 9% ≥2 severe symptoms in at least one month during this period. At six months there was no evidence of difference in the proportion of children with ≥2 symptoms between those consuming (29.5% mild‐moderate, 1.8% severe) and not consuming cow's milk (35.3% mild‐moderate, 2.2% severe). Mean monthly reporting of ≥2 symptoms was also no different between those with (15.8% mild‐moderate, 1.1% severe) or without eczema at baseline (16.7% mild‐moderate, 1.3% severe). Conclusions: Guideline‐defined symptoms of non‐IgE‐mediated CMA are very common in infants. Guidelines may promote milk allergy overdiagnosis by labelling normal infant symptoms as possible milk allergy. [ABSTRACT FROM AUTHOR]

Published
2022
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33. Research needs in allergy: an EAACI position paper, in collaboration with EFA

Author

Papadopoulos Nikolaos G, Agache Ioana, Bavbek Sevim, Bilo Beatrice M, Braido Fulvio, Cardona Victoria, Custovic Adnan, deMonchy Jan, Demoly Pascal, Eigenmann Philippe, Gayraud Jacques, Grattan Clive, Heffler Enrico, Hellings Peter W, Jutel Marek, Knol Edward, Lötvall Jan, Muraro Antonella, Poulsen Lars K, Roberts Graham, Schmid-Grendelmeier Peter, Skevaki Chrysanthi, Triggiani Massimo, vanRee Ronald, Werfel Thomas, Flood Breda, Palkonen Susanna, Savli Roberta, Allegri Pia, Annesi-Maesano Isabella, Annunziato Francesco, Antolin-Amerigo Dario, Apfelbacher Christian, Blanca Miguel, Bogacka Ewa, Bonadonna Patrizia, Bonini Matteo, Boyman Onur, Brockow Knut, Burney Peter, Buters Jeroen, Butiene Indre, Calderon Moises, Cardell Lars, Caubet Jean-Christoph, Celenk Sevcan, Cichocka-Jarosz Ewa, Cingi Cemal, Couto Mariana, deJong Nicolette, Del Giacco Stefano, Douladiris Nikolaos, Fassio Filippo, Fauquert Jean-Luc, Fernandez Javier, Rivas Montserrat, Ferrer Marta, Flohr Carsten, Gardner James, Genuneit Jon, Gevaert Philippe, Groblewska Anna, Hamelmann Eckard, Hoffmann Hans, Hoffmann-Sommergruber Karin, Hovhannisyan Lilit, Hox Valérie, Jahnsen Frode L, Kalayci Ömer, Kalpaklioglu Ayse, Kleine-Tebbe Jörg, Konstantinou George, Kurowski Marcin, Lau Susanne, Lauener Roger, Lauerma Antti, Logan Kirsty, Magnan Antoine, Makowska Joanna, Makrinioti Heidi, Mangina Paraskevi, Manole Felicia, Mari Adriano, Mazon Angel, Mills Clare, Mingomataj ErvinÇ, Niggemann Bodo, Nilsson Gunnar, Ollert Markus, O'Mahony Liam, O'Neil Serena, Pala Gianni, Papi Alberto, Passalacqua Gianni, Perkin Michael, Pfaar Oliver, Pitsios Constantinos, Quirce Santiago, Raap Ulrike, Raulf-Heimsoth Monika, Rhyner Claudio, Robson-Ansley Paula, Alves Rodrigo, Roje Zeljka, Rondon Carmen, Rudzeviciene Odilija, Ruëff Franziska, Rukhadze Maia, Rumi Gabriele, Sackesen Cansin, Santos Alexandra F, Santucci Annalisa, Scharf Christian, Schmidt-Weber Carsten, Schnyder Benno, Schwarze Jürgen, Senna Gianenrico, Sergejeva Svetlana, Seys Sven, Siracusa Andrea, Skypala Isabel, Sokolowska Milena, Spertini Francois, Spiewak Radoslaw, Sprikkelman Aline, Sturm Gunter, Swoboda Ines, Terreehorst Ingrid, Toskala Elina, Traidl-Hoffmann Claudia, Venter Carina, Vlieg-Boerstra Berber, Whitacker Paul, Worm Margitta, Xepapadaki Paraskevi, and Akdis Cezmi A

Subjects
Allergy, Allergic diseases, Policy, Research needs, Research funding, Europe, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients’ Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients’ organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.

Published
2012
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34. Challenges experienced with early introduction and sustained consumption of allergenic foods in the Enquiring About Tolerance (EAT) study: A qualitative analysis

Author

Voorheis, Paula, primary, Bell, Sadie, additional, Cornelsen, Laura, additional, Quaife, Matthew, additional, Logan, Kirsty, additional, Marrs, Tom, additional, Radulovic, Suzana, additional, Craven, Joanna, additional, Flohr, Carsten, additional, Lack, Gideon, additional, Perkin, Michael R., additional, Young, Louise, additional, Offord, Victoria, additional, DeSousa, Mary, additional, Cullen, Jason, additional, Taylor, Katherine, additional, Tseng, Anna, additional, Raji, Bunmi, additional, Byrom, Sarah, additional, Regis, Gillian, additional, Bigwood, Charlie, additional, Stedman, Charlotte, additional, Tonner, Sharon, additional, Banks, Emily, additional, Kahnum, Yasmin, additional, Babic, Rachel, additional, Stockwell, Ben, additional, Thompson, Erin, additional, Wheatley, Lorna, additional, Patkunam, Devi, additional, Richards, Kerry, additional, Pietraszewicz, Ewa, additional, Stephens, Alick, additional, Sudra, Asha, additional, and Turcanu, Victor, additional

Published
2019
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35. Factors influencing adherence in a trial of early introduction of allergenic food

Author

Perkin, Michael R., primary, Bahnson, Henry T., additional, Logan, Kirsty, additional, Marrs, Tom, additional, Radulovic, Suzana, additional, Knibb, Rebecca, additional, Craven, Joanna, additional, Flohr, Carsten, additional, Mills, E.N., additional, Versteeg, Serge A., additional, van Ree, Ronald, additional, Lack, Gideon, additional, Young, Louise, additional, Offord, Victoria, additional, DeSousa, Mary, additional, Cullen, Jason, additional, Taylor, Katherine, additional, Tseng, Anna, additional, Raji, Bunmi, additional, Byrom, Sarah, additional, Regis, Gillian, additional, Bigwood, Charlie, additional, Stedman, Charlotte, additional, Tonner, Sharon, additional, Banks, Emily, additional, Kahnum, Yasmin, additional, Babic, Rachel, additional, Stockwell, Ben, additional, Thompson, Erin, additional, Wheatley, Lorna, additional, and Patkunam, Devi, additional

Published
2019
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36. Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy

Author

Perkin, Michael R., primary, Logan, Kirsty, additional, Bahnson, Henry T., additional, Marrs, Tom, additional, Radulovic, Suzana, additional, Craven, Joanna, additional, Flohr, Carsten, additional, Mills, E.N., additional, Versteeg, Serge A., additional, van Ree, Ronald, additional, Lack, Gideon, additional, Young, Louise, additional, Offord, Victoria, additional, DeSousa, Mary, additional, Cullen, Jason, additional, Taylor, Katherine, additional, Tseng, Anna, additional, Raji, Bunmi, additional, Byrom, Sarah, additional, Regis, Gillian, additional, Bigwood, Charlie, additional, Stedman, Charlotte, additional, Tonner, Sharon, additional, Banks, Emily, additional, Kahnum, Yasmin, additional, Babic, Rachel, additional, Stockwell, Ben, additional, Thompson, Erin, additional, Wheatley, Lorna, additional, Patkunam, Devi, additional, Richards, Kerry, additional, Pietraszewicz, Ewa, additional, Stephens, Alick, additional, Sudra, Asha, additional, and Turcanu, Victor, additional

Published
2019
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38. MOESM1 of The state of asthma epidemiology: an overview of systematic reviews and their quality

Author

Genuneit, Jon, Seibold, Annina, Apfelbacher, Christian, Konstantinou, George, Koplin, Jennifer, Grutta, Stefania, Logan, Kirsty, Flohr, Carsten, and Perkin, Michael

Abstract

Additional file 1: Tables S1. AMSTAR checklist with “liberal” and “conservative” instructions. Table S2. Topic index terms and their aggregation. Figure S1. Profile lines of adjusted mean liberal and conservative AMSTAR scores across topics.

Published
2017
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39. The Association between Domestic Water Hardness, Chlorine and Atopic Dermatitis Risk in Early Life:A Population-Based Cross-Sectional Study

Author

Perkin, Michael R., Craven, Joanna, Logan, Kirsty, Strachan, David, Marrs, Tom, Radulovic, Suzana, Campbell, Linda E., MacCallum, Stephanie F., McLean, W.H. Irwin, Lack, Gideon, and Flohr, Carsten

Subjects
atopic dermatitis, polycyclic compounds, transepidermal water loss, eczema, water hardness, Filaggrin
Abstract

BackgroundDomestic water hardness and chlorine have been suggested as important risk factors for atopic dermatitis (AD).ObjectiveWe sought to examine the link between domestic water calcium carbonate (CaCO3) and chlorine concentrations, skin barrier dysfunction (increased transepidermal water loss), and AD in infancy.MethodsWe recruited 1303 three-month-old infants from the general population and gathered data on domestic water CaCO3 (in milligrams per liter) and chlorine (Cl2; in milligrams per liter) concentrations from local water suppliers. At enrollment, infants were examined for AD and screened for filaggrin (FLG) skin barrier gene mutation status. Transepidermal water loss was measured on unaffected forearm skin.ResultsCaCO3 and chlorine levels were strongly correlated. A hybrid variable of greater than and less than median levels of CaCO3 and total chlorine was constructed: a baseline group of low CaCO3/low total chlorine (CaL/ClL), high CaCO3/low total chlorine (CaH/ClL), low CaCO3/high total chlorine (CaL/ClH) and high CaCO3/high total chlorine (CaH/ClH). Visible AD was more common in all 3 groups versus the baseline group: adjusted odds ratio (AOR) of 1.87 (95% CI, 1.25-2.80; P = .002) for the CaH/ClL group, AOR of 1.46 (95% CI, 0.97-2.21; P = .07) for the CaL/ClH, and AOR of 1.61 (95% CI, 1.09-2.38; P = .02) for the CaH/ClH group. The effect estimates were greater in children carrying FLG mutations, but formal interaction testing between water quality groups and filaggrin status was not statistically significant.ConclusionsHigh domestic water CaCO3 levels are associated with an increased risk of AD in infancy. The influence of increased total chlorine levels remains uncertain. An intervention trial is required to see whether installation of a domestic device to decrease CaCO3 levels around the time of birth can reduce this risk.

Published
2016
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40. Dog ownership at three months of age is associated with protection against food allergy.

Author

Marrs, Tom, Logan, Kirsty, Craven, Joanna, Radulovic, Suzana, McLean, W.H.A. Irwin, Lack, Gideon, Flohr, Carsten, Perkin, Michael R., Young, Louise, Offord, Victoria, DeSousa, Mary, Cullen, Jason, Taylor, Katherine, Tseng, Anna, Raji, Bunmi, Byrom, Sarah, Regis, Gillian, Bigwood, Charlie, Stedman, Charlotte, and Tonner, Sharon

Subjects
*FOOD allergy, *ATOPIC dermatitis, *DOG food, *GENETIC disorders, *ALLERGIES
Abstract

Background: The prevention of food allergy is a key priority for reducing the burden of allergic disease. Environmental exposures modulate the risk of developing food allergy and some of this may be mediated by the infants' developing microbiome. However, the role of potentially protective environmental exposures, such as pet ownership, is largely uninvestigated with respect to food allergy. Methods: We performed a secondary cohort analysis in the Enquiring About Tolerance (EAT) study, which enrolled 1303 three‐month infants onto a randomized trial to prevent food allergy. A survey elicited domestic animal ownership and participants were examined for atopic dermatitis (AD) at enrolment. Sensitization to foods and aeroallergens were elicited by skin and serum testing at 3, 12 and 36 months. Food allergy status was determined by double‐blind placebo‐controlled food challenges between 1 and 3 years. Results: Food allergy was diagnosed amongst 6.1% (68/1124) of participants with complete data. No significant relationships were demonstrated between food allergy and caesarean delivery, infections or antibiotic exposure in early life. After adjusting for familial atopic disease, maternal dog/cat sensitization and participant AD, living with dogs was associated with a 90% reduction in the odds of infants developing food allergy (adjusted odds ratio (aOR) 0.10 (confidence interval (CI) 0.01‐0.71), P = 0.02). None of the 49 infants living with at least two dogs developed food allergy, suggesting a dose‐response relationship (each dog owned aOR 0.12 (CI 0.02‐0.81), P = 0.03). No relationship was demonstrated between owning dogs or cats and the development of AD. Conclusion: Dog ownership in infancy may prevent food allergy. [ABSTRACT FROM AUTHOR]

Published
2019
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41. Modifying the infant's diet to prevent food allergy

Author

Grimshaw, Kate, primary, Logan, Kirsty, additional, O'Donovan, Sinead, additional, Kiely, Mairead, additional, Patient, Karine, additional, van Bilsen, Jolanda, additional, Beyer, Kirsten, additional, Campbell, Dianne E, additional, Garcia-Larsen, Vanessa, additional, Grabenhenrich, Linus, additional, Lack, Gideon, additional, Mills, Clare, additional, Wal, Jean-Michel, additional, and Roberts, Graham, additional

Published
2016
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42. Association between domestic water hardness, chlorine, and atopic dermatitis risk in early life: A population-based cross-sectional study

Author

Perkin, Michael R., primary, Craven, Joanna, additional, Logan, Kirsty, additional, Strachan, David, additional, Marrs, Tom, additional, Radulovic, Suzana, additional, Campbell, Linda E., additional, MacCallum, Stephanie F., additional, McLean, W.H. Irwin, additional, Lack, Gideon, additional, Flohr, Carsten, additional, Young, Louise, additional, Offord, Victoria, additional, DeSousa, Mary, additional, Cullen, Jason, additional, Taylor, Katherine, additional, Tseng, Anna, additional, Raji, Bunmi, additional, Nesbeth, Sarah, additional, Regis, Gillian, additional, Bigwood, Charlie, additional, Stedman, Charlotte, additional, Tonner, Sharon, additional, Banks, Emily, additional, Kahnum, Yasmin, additional, Babic, Rachel, additional, Stockwell, Ben, additional, Thompson, Erin, additional, Wheatley, Lorna, additional, Patkunam, Devi, additional, Richards, Kerry, additional, Pietraszewicz, Ewa, additional, Stephens, Alick, additional, Sudra, Asha, additional, and Turcanu, Victor, additional

Published
2016
Full Text
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45. Four extracts from The Gloaming.

Author

Logan, Kirsty

Subjects
EARTH tides, MARRIAGE, QUILTS
Abstract

A literary criticism of the book " The Gloaming" is presented. It outlines that the author offers in sparkling creative prose the subtle ways of Scottish enchantment stories and the manner in which creatures from the ‘outside' intrude upon mortal folk. It examines girls who were raised on fairy tales and the kind of books that would curdle blood.

Published
2018

46. Research needs in allergy: an EAACI position paper, in collaboration with EFA

Author

KUL - University Hospitals Leuven, Spertini, Francois, Sokolowska, Milena, Skypala, Isabel, Spiewak, Radoslaw, Sprikkelman, Aline, Alves, Rodrigo, Sturm, Gunter, Siracusa, Andrea, Seys, Sven, Vlieg-Boerstra, Berber, Venter, Carina, Whitacker, Paul, Swoboda, Ines, Terreehorst, Ingrid, Traidl-Hoffmann, Claudia, Toskala, Elina, Robson-Ansley, Paula, Roje, Zeljka, Schnyder, Benno, Schmidt-Weber, Carsten, Scharf, Christian, Schwarze, Jürgen, Senna, Gianenrico, Akdis, Cezmi A, Sergejeva, Svetlana, Santucci, Annalisa, Santos, Alexandra F, Rudzeviciene, Odilija, Rondon, Carmen, Ruëff, Franziska, Rukhadze, Maia, Sackesen, Cansin, Rumi, Gabriele, Xepapadaki, Paraskevi, Worm, Margitta, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, deMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K, Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, vanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, deJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Ömer, Kalpaklioglu, Ayse, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, ErvinÇ, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, KUL - University Hospitals Leuven, Spertini, Francois, Sokolowska, Milena, Skypala, Isabel, Spiewak, Radoslaw, Sprikkelman, Aline, Alves, Rodrigo, Sturm, Gunter, Siracusa, Andrea, Seys, Sven, Vlieg-Boerstra, Berber, Venter, Carina, Whitacker, Paul, Swoboda, Ines, Terreehorst, Ingrid, Traidl-Hoffmann, Claudia, Toskala, Elina, Robson-Ansley, Paula, Roje, Zeljka, Schnyder, Benno, Schmidt-Weber, Carsten, Scharf, Christian, Schwarze, Jürgen, Senna, Gianenrico, Akdis, Cezmi A, Sergejeva, Svetlana, Santucci, Annalisa, Santos, Alexandra F, Rudzeviciene, Odilija, Rondon, Carmen, Ruëff, Franziska, Rukhadze, Maia, Sackesen, Cansin, Rumi, Gabriele, Xepapadaki, Paraskevi, Worm, Margitta, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, deMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K, Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, vanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, deJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Ömer, Kalpaklioglu, Ayse, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, ErvinÇ, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, and Rhyner, Claudio

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treat

Published
2012

47. Research needs in allergy:An EAACI position paper, in collaboration with EFA

Author

Papadopoulos, Nikolaos G., Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M., Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, DeMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W., Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, VanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, DeJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L., Kalayci, Ömer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F., Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, Akdis, Cezmi A., Papadopoulos, Nikolaos G., Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M., Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, DeMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W., Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, VanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, DeJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L., Kalayci, Ömer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F., Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, and Akdis, Cezmi A.

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and

Published
2012

48. Research needs in allergy:an EAACI position paper, in collaboration with EFA

Author

Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin C, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, Akdis, Cezmi A, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin C, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, and Akdis, Cezmi A

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform

Published
2012

50. Lack of uniformity in the investigation and management of suspected β-lactam allergy in children.

Author

Foong, Ru Xin, Logan, Kirsty, Perkin, Michael Richard, and Toit, George

Subjects
*ALLERGIES, *ALLERGY in children, *DRUG allergy, *IMMUNOGLOBULIN E, *DRUG side effects
Abstract

Background Beta-lactam allergy is commonly suspected in childhood with health implications for the individual and wider public. Diagnostic modalities include skin prick tests ( SPT), specific immunoglobulin-E (sp-IgE) tests, intradermal tests ( IDT) and drug provocation challenges ( DPC). The aim of this research was to establish whether variation exists around the world in the investigation and management of beta-lactam allergy. Methods Anonymized electronic questionnaire surveys were distributed over 3 months through International Allergy Societies for completion by clinicians who investigate drug allergy in children. Results Eighty-one clinicians, practising in 16 countries, completed the questionnaire. There is variability in the selection of diagnostic tests used by clinicians around the world and poor agreement on positive cut-off values (sp-IgE, SPT and IDT) and practical techniques used to measure SPT or IDT wheal diameters. DPC were considered the gold standard investigation with 94% of respondents undertaking DPC over the last 12 months; 64% of respondents considered DPC extremely useful for both exclusion and confirmation of beta-lactam allergy. However, there is a lack of consensus on when and how DPC should be performed. Overall, DPC are safe - only 3% of our respondents had patients who required intramuscular adrenaline and none had patients requiring admission to intensive care. Conclusions There is lack of consistency amongst clinicians in different countries in the diagnosis and management of suspected beta-lactam allergy. The development of a standardized approach is a priority. [ABSTRACT FROM AUTHOR]

Published
2016
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