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18 results on '"Loeliger, Susanne"'

1. Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis

Author

Alfvén, Tobias, Alm, Johan, Bergström, Anna, Engstrand, Lars, Rosenlund, Helen, Hakansson, Niclas, Lilja, Gunnar, Nyberg, Frederik, Swartz, Jackie, Wickman, Magnus, Wildhaber, Johannes, Möller, Alex, Brunekreef, Bert, Boeve, Mirian, Douwes, Jeroen, Huber, Machteld, Gertraud Weiss, Mirjam Matze, Schreue, Mynda, Michles, Karin B., Sennhauser, Felix, Scheynius, Annika, Hirvonen, Maija-Riitta, Remes, Sami, Roponen, Marjut, Tiittanen, Pekka, Dalphin, Marie-Laure, Gisela Buchele, Vincent Kaulek, Ege, Markus, Kabesch, Michael, Pfefferle, Petra, Loss, Georg, Hyvärinen, Anne, Frei, Remo, Ferstl, Ruth, Roduit, Caroline, Ziegler, Mario, Schiavi, Elisa, Barcik, Weronika, Rodriguez-Perez, Noelia, Wirz, Oliver F., Wawrzyniak, Marcin, Pugin, Benoit, Nehrbass, Dirk, Jutel, Marek, Smolinska, Sylwia, Konieczna, Patrycja, Bieli, Christian, Loeliger, Susanne, Waser, Marco, Pershagen, Göran, Riedler, Josef, Depner, Martin, Schaub, Bianca, Genuneit, Jon, Renz, Harald, Pekkanen, Juha, Karvonen, Anne M., Dalphin, Jean-Charles, van Hage, Marianne, Doekes, Gert, Akdis, Mübeccel, Braun-Fahrländer, Charlotte, Akdis, Cezmi A., von Mutius, Erika, O’Mahony, Liam, and Lauener, Roger P.

Published
2018
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2. Exposure to nonmicrobial N-glycolylneuraminic acid protects farmersʼ children against airway inflammation and colitis

Author

Frei, Remo, Ferstl, Ruth, Roduit, Caroline, Ziegler, Mario, Schiavi, Elisa, Barcik, Weronika, Rodriguez-Perez, Noelia, Wirz, Oliver F., Wawrzyniak, Marcin, Pugin, Benoit, Nehrbass, Dirk, Jutel, Marek, Smolinska, Sylwia, Konieczna, Patrycja, Bieli, Christian, Loeliger, Susanne, Waser, Marco, Pershagen, Göran, Riedler, Josef, Depner, Martin, Schaub, Bianca, Genuneit, Jon, Renz, Harald, Pekkanen, Juha, Karvonen, Anne M., Dalphin, Jean-Charles, van Hage, Marianne, Doekes, Gert, Akdis, Mübeccel, Braun-Fahrländer, Charlotte, Akdis, Cezmi A., von Mutius, Erika, OʼMahony, Liam, Lauener, Roger P., Alfvén, Tobias, Alm, Johan, Bergström, Anna, Engstrand, Lars, Rosenlund, Helen, Hakansson, Niclas, Lilja, Gunnar, Nyberg, Frederik, Swartz, Jackie, Wickman, Magnus, Wildhaber, Johannes, Möller, Alex, Brunekreef, Bert, Boeve, Mirian, Douwes, Jeroen, Huber, Machteld, Weiss, Mirjam Matze Gertraud, Schreue, Mynda, Michles, Karin B., Sennhauser, Felix, Scheynius, Annika, Hirvonen, Maija-Riitta, Remes, Sami, Roponen, Marjut, Tiittanen, Pekka, Dalphin, Marie-Laure, Buchele, Vincent Kaulek Gisela, Ege, Markus, Kabesch, Michael, Pfefferle, Petra, Loss, Georg, and Hyvärinen, Anne

Published
2018
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5. Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma

Author

Weber-Chrysochoou, Christina; https://orcid.org/0000-0002-3671-8079, Darcan-Nicolaisen, Yasemin, Wohlgensinger, Johanna, Tinner, Eva Maria, Frei, Remo, Loeliger, Susanne, Lauener, Roger P, Hamelmann, Eckard, Weber-Chrysochoou, Christina; https://orcid.org/0000-0002-3671-8079, Darcan-Nicolaisen, Yasemin, Wohlgensinger, Johanna, Tinner, Eva Maria, Frei, Remo, Loeliger, Susanne, Lauener, Roger P, and Hamelmann, Eckard

Abstract

Introduction: Environmental exposure to mites and fungi has been proposed to critically contribute to the development of IgE-mediated asthma. A common denominator of such organisms is chitin. Human chitinases have been reported to be upregulated by interleukin-13 secreted in the context of Th2-type immune responses and to induce asthma. We assessed whether chitin-containing components induced chitinases in an innate immune-dependent way and whether this results in bronchial hyperresponsiveness. Materials and methods: Monocyte/macrophage cell lines were stimulated with chitin-containing or bacterial components in vitro. Chitinase activity in the supernatant and the expression of the chitotriosidase gene were measured by enzyme assay and quantitative PCR, respectively. Non-sensitized mice were stimulated with chitin-containing components intranasally, and a chitinase inhibitor was administered intraperitoneally. As markers for inflammation leukocytes were counted in the bronchoalveolar lavage (BAL) fluid, and airway hyperresponsiveness was assessed via methacholine challenge. Results: We found both whole chitin-containing dust mites as well as the fungal cell wall component zymosan A but not endotoxin-induced chitinase activity and chitotriosidase gene expression in vitro. The intranasal application of zymosan A into mice led to the induction of chitinase activity in the BAL fluid and to bronchial hyperresponsiveness, which could be reduced by applying the chitinase inhibitor allosamidin. Discussion: We propose that environmental exposure to mites and fungi leads to the induction of chitinase, which in turn favors the development of bronchial hyperreactivity in an IgE-independent manner. Keywords: Airway inflammation; Chitinase; Fungi; Innate immune system; Mites

Published
2021

7. High levels of butyrate and propionate in early life are associated with protection against atopy

Author

Roduit, Caroline, Frei, Remo, Ferstl, Ruth, Loeliger, Susanne, Westermann, Patrick, Rhyner, Claudio, Schiavi, Elisa, Barcik, Weronika, Rodriguez-Perez, Noelia, Wawrzyniak, Marcin, Chassard, Christophe, Lacroix, Christophe, et al, PASTURE/EFRAIM study group, University of Zurich, and Roduit, Caroline

Subjects
2403 Immunology, 10036 Medical Clinic, 10183 Swiss Institute of Allergy and Asthma Research, 2723 Immunology and Allergy, 610 Medicine & health
Published
2019

9. Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis

Author

dIRAS RA-2, LS IRAS EEPI GRA (Gezh.risico-analyse), Frei, Remo, Ferstl, Ruth, Roduit, Caroline, Ziegler, Mario, Schiavi, Elisa, Barcik, Weronika, Rodriguez-Perez, Noelia, Wirz, Oliver F, Wawrzyniak, Marcin, Pugin, Benoit, Nehrbass, Dirk, Jutel, Marek, Smolinska, Sylwia, Konieczna, Patrycja, Bieli, Christian, Loeliger, Susanne, Waser, Marco, Pershagen, Göran, Riedler, Josef, Depner, Martin, Schaub, Bianca, Genuneit, Jon, Renz, Harald, Pekkanen, Juha, Karvonen, Anne M, Dalphin, Jean-Charles, van Hage, Marianne, Doekes, Gert, Akdis, Mübeccel, Braun-Fahrländer, Charlotte, Akdis, Cezmi A, von Mutius, Erika, O'Mahony, Liam, Lauener, Roger P, Prevention of Allergy Risk factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle (PARSIFAL) study group, dIRAS RA-2, LS IRAS EEPI GRA (Gezh.risico-analyse), Frei, Remo, Ferstl, Ruth, Roduit, Caroline, Ziegler, Mario, Schiavi, Elisa, Barcik, Weronika, Rodriguez-Perez, Noelia, Wirz, Oliver F, Wawrzyniak, Marcin, Pugin, Benoit, Nehrbass, Dirk, Jutel, Marek, Smolinska, Sylwia, Konieczna, Patrycja, Bieli, Christian, Loeliger, Susanne, Waser, Marco, Pershagen, Göran, Riedler, Josef, Depner, Martin, Schaub, Bianca, Genuneit, Jon, Renz, Harald, Pekkanen, Juha, Karvonen, Anne M, Dalphin, Jean-Charles, van Hage, Marianne, Doekes, Gert, Akdis, Mübeccel, Braun-Fahrländer, Charlotte, Akdis, Cezmi A, von Mutius, Erika, O'Mahony, Liam, Lauener, Roger P, and Prevention of Allergy Risk factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle (PARSIFAL) study group

Published
2018

10. Expression of Genes Related to Anti-Inflammatory Pathways Are Modified Among Farmers’ Children

Author

Frei, Remo, Roduit, Caroline, Bieli, Christian, Loeliger, Susanne, Waser, Marco, Scheynius, Annika, Van Hage, Marianne, Pershagen, Göran, Doekes, Gert, Riedler, Josef, Von Mutius, Erika, Sennhauser, Felix, Akdis, Cezmi A., Braun-Fahrländer, Charlotte, Lauener, Roger P., LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, University of Zurich, LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, and IRAS RATIA2

Subjects
Male, Allergy, Epidemiology, lcsh:Medicine, Adaptive Immunity, Immunoglobulin E, Biochemistry, 0302 clinical medicine, 10183 Swiss Institute of Allergy and Asthma Research, immune system diseases, lcsh:Science, Child, Immune Response, 2. Zero hunger, Regulation of gene expression, Medicine(all), 0303 health sciences, Molecular Epidemiology, Multidisciplinary, Agricultural and Biological Sciences(all), Allergy and Hypersensitivity, Toll-Like Receptors, Agriculture, T helper cell, Acquired immune system, Innate Immunity, 3. Good health, medicine.anatomical_structure, Child, Preschool, Receptors, Pattern Recognition, Workforce, Cytokines, Medicine, Female, Research Article, Signal Transduction, Immunology, Immunoglobulins, 610 Medicine & health, 1100 General Agricultural and Biological Sciences, Biology, Immune Suppression, Environmental Epidemiology, Immune Activation, Immunomodulation, 03 medical and health sciences, Immune system, Th2 Cells, Hygiene hypothesis, 1300 General Biochemistry, Genetics and Molecular Biology, medicine, Humans, 030304 developmental biology, Inflammation, 1000 Multidisciplinary, Innate immune system, Biochemistry, Genetics and Molecular Biology(all), lcsh:R, Immunity, Immunoregulation, Allergens, Th1 Cells, medicine.disease, Conjunctivitis, Immunoglobulin Class Switching, Asthma, respiratory tract diseases, Biomarker Epidemiology, 030228 respiratory system, Gene Expression Regulation, 10036 Medical Clinic, Immune System, biology.protein, lcsh:Q, Genetics and Molecular Biology(all)
Abstract

Background: The hygiene hypothesis states that children exposed to higher loads of microbes such as farmers' children suffer less from allergies later in life. Several immunological mechanisms underpinning the hygiene hypothesis have been proposed such as a shift in T helper cell balance, T regulatory cell activity, or immune regulatory mechanisms induced by the innate immunity. Objective: To investigate whether the proposed immunological mechanisms for the hygiene hypotheses are found in farmers' children. Methods: We assessed gene expression levels of 64 essential markers of the innate and adaptive immunity by quantitative real-time PCR in white blood cells in 316 Swiss children of the PARSIFAL study to compare farmers' to non-farmers' expressions and to associate them to the prevalence of asthma and rhinoconjunctivitis, total and allergen-specific IgE in serum, and expression of Ce germ-line transcripts. Results: We found enhanced expression of genes of the innate immunity such as IRAK-4 and RIPK1 and enhanced expression of regulatory molecules such as IL-10, TGF-beta, SOCS4, and IRAK-2 in farmers' children. Furthermore, farmers' children expressed less of the T(H)1 associated cytokine IFN-gamma while T(H)2 associated transcription factor GATA3 was enhanced. No significant associations between the assessed immunological markers and allergic diseases or sensitization to allergens were observed. Conclusion: Farmers' children express multiple increased innate immune response and immune regulatory molecules, which may contribute to the mechanisms of action of the hygiene hypothesis.

Published
2014

12. Expression of genes related to anti-inflammatory pathways are modified among farmers' children

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Frei, Remo, Roduit, Caroline, Bieli, Christian, Loeliger, Susanne, Waser, Marco, Scheynius, Annika, Van Hage, Marianne, Pershagen, Göran, Doekes, Gert, Riedler, Josef, Von Mutius, Erika, Sennhauser, Felix, Akdis, Cezmi A., Braun-Fahrländer, Charlotte, Lauener, Roger P., LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Frei, Remo, Roduit, Caroline, Bieli, Christian, Loeliger, Susanne, Waser, Marco, Scheynius, Annika, Van Hage, Marianne, Pershagen, Göran, Doekes, Gert, Riedler, Josef, Von Mutius, Erika, Sennhauser, Felix, Akdis, Cezmi A., Braun-Fahrländer, Charlotte, and Lauener, Roger P.

Published
2014

17. Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis

Author

Frei, Remo, Ferstl, Ruth, Roduit, Caroline, Ziegler, Mario, Schiavi, Elisa, Barcik, Weronika, Rodriguez-Perez, Noelia, Wirz, Oliver F., Wawrzyniak, Marcin, Pugin, Benoit, Nehrbass, Dirk, Jutel, Marek, Smolinska, Sylwia, Konieczna, Patrycja, Bieli, Christian, Loeliger, Susanne, Waser, Marco, Pershagen, Göran, Riedler, Josef, Depner, Martin, Schaub, Bianca, Genuneit, Jon, Renz, Harald, Pekkanen, Juha, Karvonen, Anne M., Dalphin, Jean-Charles, van Hage, Marianne, Doekes, Gert, Akdis, Mübeccel, Braun-Fahrländer, Charlotte, Akdis, Cezmi A., von Mutius, Erika, O'Mahony, Liam, Lauener, Roger P., Prevention of Allergy Risk factors for Sensitization in Children, Anthroposophic Lifestyle study group, and Protection Against Allergy Study in Rural Environments /Mechanis

Subjects
3. Good health

18. High levels of butyrate and propionate in early life are associated with protection against atopy.

Author

Roduit C, Frei R, Ferstl R, Loeliger S, Westermann P, Rhyner C, Schiavi E, Barcik W, Rodriguez-Perez N, Wawrzyniak M, Chassard C, Lacroix C, Schmausser-Hechfellner E, Depner M, von Mutius E, Braun-Fahrländer C, Karvonen AM, Kirjavainen PV, Pekkanen J, Dalphin JC, Riedler J, Akdis C, Lauener R, and O'Mahony L

Subjects
Animals, Asthma etiology, Chromatography, High Pressure Liquid, Diet, Fatty Acids, Volatile analysis, Feces chemistry, Female, Humans, Hypersensitivity, Immediate etiology, Infant, Male, Mice, Asthma prevention & control, Butyrates analysis, Hypersensitivity, Immediate prevention & control, Propionates analysis
Abstract

Background: Dietary changes are suggested to play a role in the increasing prevalence of allergic diseases and asthma. Short-chain fatty acids (SCFAs) are metabolites present in certain foods and are produced by microbes in the gut following fermentation of fibers. SCFAs have been shown to have anti-inflammatory properties in animal models. Our objective was to investigate the potential role of SCFAs in the prevention of allergy and asthma., Methods: We analyzed SCFA levels by high-performance liquid chromatography (HPLC) in fecal samples from 301 one-year-old children from a birth cohort and examined their association with early life exposures, especially diet, and allergy and asthma later in life. Data on exposures and allergic diseases were collected by questionnaires. In addition, we treated mice with SCFAs to examine their effect on allergic airway inflammation., Results: Significant associations between the levels of SCFAs and the infant's diet were identified. Children with the highest levels of butyrate and propionate (≥95th percentile) in feces at the age of one year had significantly less atopic sensitization and were less likely to have asthma between 3 and 6 years. Children with the highest levels of butyrate were also less likely to have a reported diagnosis of food allergy or allergic rhinitis. Oral administration of SCFAs to mice significantly reduced the severity of allergic airway inflammation., Conclusion: Our results suggest that strategies to increase SCFA levels could be a new dietary preventive option for allergic diseases in children., (© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.)

Published
2019
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