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17 results on '"Loef, Dore"'

1. A prediction model for electroconvulsive therapy effectiveness in patients with major depressive disorder from the Dutch ECT Consortium (DEC)

Author

Loef, Dore, Hoogendoorn, Adriaan W., Somers, Metten, Mocking, Roel J. T., Scheepens, Dominique S., Scheepstra, Karel W. F., Blijleven, Maaike, Hegeman, Johanna M., van den Berg, Karen S., Schut, Bart, Birkenhager, Tom K., Heijnen, Willemijn, Rhebergen, Didi, Oudega, Mardien L., Schouws, Sigfried N. T. M., van Exel, Eric, Rutten, Bart P. F., Broekman, Birit F. P., Vergouwen, Anton C. M., Zoon, Thomas J. C., Kok, Rob M., Somers, Karina, Verwijk, Esmée, Rovers, Jordy J. E., Schuur, Gijsbert, van Waarde, Jeroen A., Verdijk, Joey P. A. J., Bloemkolk, Dieneke, Gerritse, Frank L., van Welie, Hanneke, Haarman, Bartholomeus C. M., van Belkum, Sjoerd M., Vischjager, Maurice, Hagoort, Karin, van Dellen, Edwin, Tendolkar, Indira, van Eijndhoven, Philip F. P., and Dols, Annemiek

Published
2024
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6. Pre-treatment predictors of cognitive side-effects after treatment with electroconvulsive therapy in patients with depression: A multicenter study

Author

Hersenen-Medisch 1, Affectieve & Psychotische Med., Brain, Acuut & Intensieve Zorg Med., Loef, Dore, van Eijndhoven, Philip, van den Munckhof, Eva, Hoogendoorn, Adriaan, Manten, Ruby, Spaans, Harm-Pieter, Tendolkar, Indira, Rutten, Bart, Nuninga, Jasper, Somers, Metten, van Dellen, Edwin, van Exel, Eric, Schouws, Sigfried, Dols, Annemiek, Verwijk, Esmée, Hersenen-Medisch 1, Affectieve & Psychotische Med., Brain, Acuut & Intensieve Zorg Med., Loef, Dore, van Eijndhoven, Philip, van den Munckhof, Eva, Hoogendoorn, Adriaan, Manten, Ruby, Spaans, Harm-Pieter, Tendolkar, Indira, Rutten, Bart, Nuninga, Jasper, Somers, Metten, van Dellen, Edwin, van Exel, Eric, Schouws, Sigfried, Dols, Annemiek, and Verwijk, Esmée

Published
2024

7. Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients

Author

Pathologie, Acuut & Intensieve Zorg Med., Brain, Loef, Dore, Tendolkar, Indira, van Eijndhoven, Philip F P, Hoozemans, Jeroen J M, Oudega, Mardien L, Rozemuller, Annemieke J M, Lucassen, Paul J, Dols, Annemiek, Dijkstra, Anke A, Pathologie, Acuut & Intensieve Zorg Med., Brain, Loef, Dore, Tendolkar, Indira, van Eijndhoven, Philip F P, Hoozemans, Jeroen J M, Oudega, Mardien L, Rozemuller, Annemieke J M, Lucassen, Paul J, Dols, Annemiek, and Dijkstra, Anke A

Published
2023

11. Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness

Author

Luykx, Jurjen J., Loef, Dore, Lin, Bochao, van Diermen, Linda, Nuninga, Jasper O., van Exel, Eric, Oudega, Mardien L., Rhebergen, Didi, Schouws, Sigfried N.T.M., van Eijndhoven, Philip, Verwijk, Esmée, Schrijvers, Didier, Birkenhager, Tom K., Ryan, Karen M., Arts, Baer, van Bronswijk, Suzanne C., Kenis, Gunter, Schurgers, Geert, Baune, Bernhard T., Arns, Martijn, van Dellen, Edwin E., Somers, Metten, Sommer, Iris E.C., Boks, Marco P., Gülöksüz, Sinan, McLoughlin, Declan M., Dols, Annemiek, Rutten, Bart P.F., Luykx, Jurjen J., Loef, Dore, Lin, Bochao, van Diermen, Linda, Nuninga, Jasper O., van Exel, Eric, Oudega, Mardien L., Rhebergen, Didi, Schouws, Sigfried N.T.M., van Eijndhoven, Philip, Verwijk, Esmée, Schrijvers, Didier, Birkenhager, Tom K., Ryan, Karen M., Arts, Baer, van Bronswijk, Suzanne C., Kenis, Gunter, Schurgers, Geert, Baune, Bernhard T., Arns, Martijn, van Dellen, Edwin E., Somers, Metten, Sommer, Iris E.C., Boks, Marco P., Gülöksüz, Sinan, McLoughlin, Declan M., Dols, Annemiek, and Rutten, Bart P.F.

Abstract

Background: Electroconvulsive therapy (ECT) is the most effective treatment for severe major depressive episodes (MDEs). Nonetheless, firmly established associations between ECT outcomes and biological variables are currently lacking. Polygenic risk scores (PRSs) carry clinical potential, but associations with treatment response in psychiatry are seldom reported. Here, we examined whether PRSs for major depressive disorder, schizophrenia (SCZ), cross-disorder, and pharmacological antidepressant response are associated with ECT effectiveness. Methods: A total of 288 patients with MDE from 3 countries were included. The main outcome was a change in the 17-item Hamilton Depression Rating Scale scores from before to after ECT treatment. Secondary outcomes were response and remission. Regression analyses with PRSs as independent variables and several covariates were performed. Explained variance (R2) at the optimal p-value threshold is reported. Results: In the 266 subjects passing quality control, the PRS-SCZ was positively associated with a larger Hamilton Depression Rating Scale decrease in linear regression (optimal p-value threshold = .05, R2 = 6.94%, p < .0001), which was consistent across countries: Ireland (R2 = 8.18%, p = .0013), Belgium (R2 = 6.83%, p = .016), and the Netherlands (R2 = 7.92%, p = .0077). The PRS-SCZ was also positively associated with remission (R2 = 4.63%, p = .0018). Sensitivity and subgroup analyses, including in MDE without psychotic features (R2 = 4.42%, p = .0024) and unipolar MDE only (R2 = 9.08%, p < .0001), confirmed the results. The other PRSs were not associated with a change in the Hamilton Depression Rating Scale score at the predefined Bonferroni-corrected significance threshold. Conclusions: A linear association between PRS-SCZ and ECT outcome was uncovered. Although it is too early to adopt PRSs in ECT clinical decision making, these

Published
2022

12. Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness

Author

Hersenen-Medisch 1, Onderzoeksgroep 2, Affectieve & Psychotische Med., Brain, Luykx, Jurjen J, Loef, Dore, Lin, Bochao, van Diermen, Linda, Nuninga, Jasper O, van Exel, Eric, Oudega, Mardien L, Rhebergen, Didi, Schouws, Sigfried N T M, van Eijndhoven, Philip, Verwijk, Esmée, Schrijvers, Didier, Birkenhager, Tom K, Ryan, Karen M, Arts, Baer, van Bronswijk, Suzanne C, Kenis, Gunter, Schurgers, Geert, Baune, Bernhard T, Arns, Martijn, van Dellen, Edwin E, Somers, Metten, Sommer, Iris E C, Boks, Marco P, Gülöksüz, Sinan, McLoughlin, Declan M, Dols, Annemiek, Rutten, Bart P F, Hersenen-Medisch 1, Onderzoeksgroep 2, Affectieve & Psychotische Med., Brain, Luykx, Jurjen J, Loef, Dore, Lin, Bochao, van Diermen, Linda, Nuninga, Jasper O, van Exel, Eric, Oudega, Mardien L, Rhebergen, Didi, Schouws, Sigfried N T M, van Eijndhoven, Philip, Verwijk, Esmée, Schrijvers, Didier, Birkenhager, Tom K, Ryan, Karen M, Arts, Baer, van Bronswijk, Suzanne C, Kenis, Gunter, Schurgers, Geert, Baune, Bernhard T, Arns, Martijn, van Dellen, Edwin E, Somers, Metten, Sommer, Iris E C, Boks, Marco P, Gülöksüz, Sinan, McLoughlin, Declan M, Dols, Annemiek, and Rutten, Bart P F

Published
2022

14. Interrogating Associations between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness

Author

Loef, Dore, primary, Luykx, Jurjen, additional, Lin, Bochao, additional, van Diermen, Linda, additional, Nuninga, Jasper, additional, van Exel, Eric, additional, Oudega, Mardien, additional, Rhebergen, Didi, additional, Schouws, Sigfried, additional, van Eijndhoven, Philip, additional, Verwijk, Esmée, additional, Schrijvers, Didier, additional, Birkenhager, Tom, additional, Ryan, Karen, additional, Arts, Baer, additional, van Bronswijk, Suzanne, additional, Kenis, Gunter, additional, Schurgers, Geert, additional, Baune, Bernhard, additional, Arns, Martijn, additional, van Dellen, Edwin, additional, Somers, Metten, additional, Sommer, Iris, additional, Boks, Marco, additional, Gülöksüz, Sinan, additional, McLoughlin, Declan, additional, Rutten, Bart, additional, and Dols, Annemiek, additional

Published
2022
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15. Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness

Author

Luykx, Jurjen J., primary, Loef, Dore, additional, Lin, Bochao, additional, van Diermen, Linda, additional, Nuninga, Jasper O., additional, van Exel, Eric, additional, Oudega, Mardien L., additional, Rhebergen, Didi, additional, Schouws, Sigfried N.T.M., additional, van Eijndhoven, Philip, additional, Verwijk, Esmée, additional, Schrijvers, Didier, additional, Birkenhager, Tom K., additional, Ryan, Karen M., additional, Arts, Baer, additional, van Bronswijk, Suzanne C., additional, Kenis, Gunter, additional, Schurgers, Geert, additional, Baune, Bernhard T., additional, Arns, Martijn, additional, van Dellen, Edwin E., additional, Somers, Metten, additional, Sommer, Iris E.C., additional, Boks, Marco P., additional, Gülöksüz, Sinan, additional, McLoughlin, Declan M., additional, Dols, Annemiek, additional, and Rutten, Bart P.F., additional

Published
2022
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16. The ratio and interaction between neurotrophin and immune signaling during electroconvulsive therapy in late-life depression

Author

Loef, Dore, primary, Vansteelandt, Kristof, additional, Oudega, Mardien L., additional, van Eijndhoven, Philip, additional, Carlier, Angela, additional, van Exel, Eric, additional, Rhebergen, Didi, additional, Sienaert, Pascal, additional, Vandenbulcke, Mathieu, additional, Bouckaert, Filip, additional, and Dols, Annemiek, additional

Published
2021
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