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3. A novel hemodynamic index characterizing mitral regurgitation undergoing transcatheter edge to edge repair: the mitral pulse pressure fraction

Author

Leone, A M, primary, Di Giusto, F, additional, Lucarelli, K, additional, Vicere, A, additional, Anastasia, G, additional, Galante, D, additional, Petrolati, E, additional, Burzotta, F, additional, Aurigemma, C, additional, Lombardo, A, additional, Locorotondo, G, additional, Graziani, F, additional, Casamassima, V, additional, Grimaldi, M, additional, and Trani, C, additional

Published
2023
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4. Global longitudinal strain for prediction of mortality in ST-segment elevation myocardial infarction and aortic stenosis patients: two sides of the same coin.

Author

RAVENNA, E., LOCOROTONDO, G., MANFREDONIA, L., DIANA, G., FILICE, M., GRAZIANI, F., LEONE, A. M., AURIGEMMA, C., ROMAGNOLI, E., BURZOTTA, F., TRANI, C., MASSETTI, M., LOMBARDO, A., and LANZA, G. A.

Abstract

OBJECTIVE: Global longitudinal strain (GLS) predicts major adverse events in ST-segment elevation myocardial infarction (STEMI) and aortic stenosis (AS). Different cutoff values and different end-points have been proposed for prognostic stratification. We aimed to verify whether a single GLS cut-off value can be used to identify increased risk of all-cause death in STEMI and AS. PATIENTS AND METHODS: One-hundredseventeen successfully treated first STEMI (age 63.8±12.5 yrs, 70% men) and 64 AS (age 80.3±6.9 yrs, 44% men) patients, undergoing echocardiography before discharge and before AS treatment, respectively, were retrospectively analyzed. GLS was analyzed, together with pulmonary artery systolic pressure (PASP), Killip class and Genereux stage. End-point was all-cause death at 6-month follow-up. RESULTS: All-cause death occurred in 4 (3.4%) STEMI and 5 (7.8%) AS patients (p=ns). AS patients who died had GLS similar to died STEMI patients (9.7±2.1 vs. 11.3±1.7, p=ns). GLS cut-off =12% predicted death with 89% sensitivity and 70% specificity (AUC 0.84, p=0.001): STEMI and AS patients with GLS =12% had worse survival than STEMI and AS patients with GLS >12% (log-rank p=0.001). At multivariate Cox regression analysis, lower GLS values independently predicted death (HR 0.667, 95% CI 0.451-0.986, p=0.042), and the prediction model was improved when GLS was added to old age, significant comorbidities, PASP and Killip/Genereux stage (X2 6.691 vs. 1.364, p=0.010). CONCLUSIONS: Died patients with STEMI and AS show similar values of GLS. A unique cut-off value of GLS can reliably be used to stratify the risk of all-cause death at 6-month follow-up in both two clinical settings. [ABSTRACT FROM AUTHOR]

Published
2023

5. Quantitative analysis of myocardial blood flow in surgically revascularized and not revascularized myocardial segments. A pilot PET study

Author

Grandinetti, M, Locorotondo, Gabriella, Leccisotti, Lucia, Guarneri, A, Bruno, P, Marcolini, A, Farina, Piero, Gaudino, M F, Lanza, Gaetano Antonio, Crea, Filippo, Giordano, Alessandro, Massetti, Massimo, Locorotondo, G, Leccisotti, L (ORCID:0000-0002-6000-2898), Farina, P, Lanza, G A (ORCID:0000-0003-2187-6653), Crea, F (ORCID:0000-0001-9404-8846), Giordano, A (ORCID:0000-0002-6978-0880), Massetti, M (ORCID:0000-0002-7100-8478), Grandinetti, M, Locorotondo, Gabriella, Leccisotti, Lucia, Guarneri, A, Bruno, P, Marcolini, A, Farina, Piero, Gaudino, M F, Lanza, Gaetano Antonio, Crea, Filippo, Giordano, Alessandro, Massetti, Massimo, Locorotondo, G, Leccisotti, L (ORCID:0000-0002-6000-2898), Farina, P, Lanza, G A (ORCID:0000-0003-2187-6653), Crea, F (ORCID:0000-0001-9404-8846), Giordano, A (ORCID:0000-0002-6978-0880), and Massetti, M (ORCID:0000-0002-7100-8478)

Abstract

PurposeTo prospectively compare changes in myocardial blood flow (MBF) and myocardial flow reserve (MFR) in multivessel coronary artery disease (MVCAD) patients undergoing incomplete revascularization (IR) versus complete revascularization (CR) by coronary artery bypass grafting (CABG).MethodsSeven male patients (age 68 +/- 9 years) with MVCAD underwent myocardial perfusion PET/CT with [13N]ammonia before and at least 4 months after CABG. Segmental resting and stress MBF as well as MFR were measured. Resting and during stress left ventricle ejection fraction (LVEF) were also calculated.ResultsThree patients (43%) underwent CR and four (57%) IR. Among 119 myocardial segments, 101 (85%) were revascularized, and 18 (15%) were not. After CABG, stress MBF (mL/min/gr) and MFR are significantly increased in all myocardial segments, with a greater increase in the revascularized segments (p = 0.013). In both groups, LVEF significantly decreased during stress at baseline PET (p = 0.04), but not after CABG.ConclusionStress MBF and MFR significantly improve after CABG in both revascularized and not directly revascularized myocardial segments. IR strategy may be considered in patients with high surgical risk for CR.

Published
2023

6. Global longitudinal strain for prediction of mortality in ST-segment elevation myocardial infarction and aortic stenosis patients: two sides of the same coin

Author

Ravenna, E, Locorotondo, Gabriella, Manfredonia, L, Diana, G, Filice, M, Graziani, Francesca, Leone, Antonio Maria, Aurigemma, Cristina, Romagnoli, E, Burzotta, Francesco, Trani, Carlo, Massetti, Massimo, Lombardo, Antonella, Lanza, Gaetano Antonio, Locorotondo, G, Graziani, F (ORCID:0000-0002-4520-5689), Leone, A M (ORCID:0000-0002-1276-9883), Aurigemma, C, Burzotta, F (ORCID:0000-0002-6569-9401), Trani, C (ORCID:0000-0001-9777-013X), Massetti, M (ORCID:0000-0002-7100-8478), Lombardo, A (ORCID:0000-0003-3162-1830), Lanza, G A (ORCID:0000-0003-2187-6653), Ravenna, E, Locorotondo, Gabriella, Manfredonia, L, Diana, G, Filice, M, Graziani, Francesca, Leone, Antonio Maria, Aurigemma, Cristina, Romagnoli, E, Burzotta, Francesco, Trani, Carlo, Massetti, Massimo, Lombardo, Antonella, Lanza, Gaetano Antonio, Locorotondo, G, Graziani, F (ORCID:0000-0002-4520-5689), Leone, A M (ORCID:0000-0002-1276-9883), Aurigemma, C, Burzotta, F (ORCID:0000-0002-6569-9401), Trani, C (ORCID:0000-0001-9777-013X), Massetti, M (ORCID:0000-0002-7100-8478), Lombardo, A (ORCID:0000-0003-3162-1830), and Lanza, G A (ORCID:0000-0003-2187-6653)

Abstract

Objective: Global longitudinal strain (GLS) predicts major adverse events in ST-segment elevation myocardial infarction (STEMI) and aortic stenosis (AS). Different cut-off values and different end-points have been proposed for prognostic stratification. We aimed to verify whether a single GLS cut-off value can be used to identify increased risk of all-cause death in STEMI and AS.Patients and methods: One-hundred- seventeen successfully treated first STEMI (age 63.8 +/- 12.5 yrs, 70% men) and 64 AS (age 80.3 +/- 6.9 yrs, 44% men) patients, undergoing echocardiography before discharge and before AS treatment, respectively, were retrospectively analyzed. GLS was analyzed, together with pulmonary artery systolic pressure (PASP), Killip class and Genereux stage. End-point was all-cause death at 6-month follow-up.Results: All-cause death occurred in 4 (3.4%) STEMI and 5 (7.8%) AS patients (p=ns). AS patients who died had GLS similar to died STEMI patients (9.7 +/- 2.1 vs. 11.3 +/- 1.7, p=ns). GLS cut-off <= 12% predicted death with 89% sensitivity and 70% specificity (AUC 0.84, p=0.001): STEMI and AS patients with GLS <= 12% had worse survival than STEMI and AS patients with GLS >12% (log-rank p=0.001). At multivariate Cox regression analysis, lower GLS values independently predicted death (HR 0.667, 95% CI 0.451-0.986, p=0.042), and the prediction model was improved when GLS was added to old age, significant comorbidities, PASP and Killip/Genereux stage (chi 2 6.691 vs. 1.364, p=0.010).Conclusions: Died patients with STEMI and AS show similar values of GLS. A unique cut-off value of GLS can reliably be used to stratify the risk of all-cause death at 6-month follow-up in both two clinical settings.

Published
2023

7. Acute haemodynamic impact of transcatheter aortic valve implantation in patients with severe aortic stenosis

Author

Graziani, Francesca, Cialdella, P., Lillo, Rosa, Locorotondo, Gabriella, Genuardi, L., Ingrasciotta, Gessica, Cangemi, Stefano, Nesta, Marialisa, Bruno, Piergiorgio, Aurigemma, Cristina, Romagnoli, Elisa, Calabrese, Michele, Giambusso, N., Lombardo, Antonella, Burzotta, Francesco, Trani, Carlo, Graziani F. (ORCID:0000-0002-4520-5689), Lillo R., Locorotondo G., Ingrasciotta G., Cangemi S., Nesta M., Bruno P. (ORCID:0000-0002-1075-5808), Aurigemma C., Romagnoli E., Calabrese M., Lombardo A. (ORCID:0000-0003-3162-1830), Burzotta F. (ORCID:0000-0002-6569-9401), Trani C. (ORCID:0000-0001-9777-013X), Graziani, Francesca, Cialdella, P., Lillo, Rosa, Locorotondo, Gabriella, Genuardi, L., Ingrasciotta, Gessica, Cangemi, Stefano, Nesta, Marialisa, Bruno, Piergiorgio, Aurigemma, Cristina, Romagnoli, Elisa, Calabrese, Michele, Giambusso, N., Lombardo, Antonella, Burzotta, Francesco, Trani, Carlo, Graziani F. (ORCID:0000-0002-4520-5689), Lillo R., Locorotondo G., Ingrasciotta G., Cangemi S., Nesta M., Bruno P. (ORCID:0000-0002-1075-5808), Aurigemma C., Romagnoli E., Calabrese M., Lombardo A. (ORCID:0000-0003-3162-1830), Burzotta F. (ORCID:0000-0002-6569-9401), and Trani C. (ORCID:0000-0001-9777-013X)

Abstract

Aims: There are limited data about the intraprocedural haemodynamic study performed immediately before and after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis (AS). We aimed to evaluate the acute haemodynamic impact of TAVI in patients with severe AS and to investigate invasive and non-invasive parameters predicting all-cause mortality. Methods and results: A total of 245 consecutive AS patients (43% male, mean age 80.3 ± 7.3 years) undergoing TAVI were enrolled. Intraprocedural left heart catheterization (LHC) and echocardiogram before and after TAVI were performed. The clinical endpoint was the death for any cause. LHC after TAVI revealed significant changes in aortic and left ventricular (LV) pressures, including indexes of intrinsic myocardial contractility and diastolic function such as positive dP/dT (1128.9 ± 398.7 vs. 806.3 ± 247.2 mmHg/s, P ˂ 0.001) and negative dP/dT (1310.7 ± 431.1 vs. 1075.1 ± 440.8 mmHg/s, P ˂ 0.001). Post-TAVI echo showed a significant reduction in LV end-diastolic (P = 0.036) and end-systolic (P ˂ 0.001) diameters, improvement in LV ejection fraction (from 55 ± 12% to 57.2 ± 10.5%, P ˂ 0.001), and pulmonary artery systolic pressure (42.1 ± 14.2 vs. 33.1 ± 10.7 mmHg, P < 0.001). After a mean follow-up time interval of 24 months, 47 patients died. Post-TAVI significant aortic regurgitation at echocardiography was the only independent predictor of mortality (hazard ratio 5.592, confidence interval 1.932–16.184, P = 0.002). Conclusions: Left heart catheterization performed immediately before and after prosthesis release offers a unique insight in the assessment of LV adaptation to severe AS and the impact of TAVI on LV, catching changes in indexes of intrinsic contractility and myocardial relaxation. Aortic regurg

Published
2022

8. Transcatheter aortic valve implantation in pure aortic regurgitation: Hemodynamic and echocardiographic findings in bioprosthesis vs. native valve

Author

Paraggio, L., Burzotta, Francesco, Graziani, Francesca, Aurigemma, Cristina, Romagnoli, Elisa, Pedicino, Daniela, Locorotondo, Gabriella, Mencarelli, E., Lillo, Rosa, Bruno, Piergiorgio, Laezza, Domenico, Giambusso, N., Lombardo, Antonella, Trani, Carlo, Burzotta F. (ORCID:0000-0002-6569-9401), Graziani F. (ORCID:0000-0002-4520-5689), Aurigemma C., Romagnoli E., Pedicino D., Locorotondo G., Lillo R., Bruno P. (ORCID:0000-0002-1075-5808), Laezza D., Lombardo A. (ORCID:0000-0003-3162-1830), Trani C. (ORCID:0000-0001-9777-013X), Paraggio, L., Burzotta, Francesco, Graziani, Francesca, Aurigemma, Cristina, Romagnoli, Elisa, Pedicino, Daniela, Locorotondo, Gabriella, Mencarelli, E., Lillo, Rosa, Bruno, Piergiorgio, Laezza, Domenico, Giambusso, N., Lombardo, Antonella, Trani, Carlo, Burzotta F. (ORCID:0000-0002-6569-9401), Graziani F. (ORCID:0000-0002-4520-5689), Aurigemma C., Romagnoli E., Pedicino D., Locorotondo G., Lillo R., Bruno P. (ORCID:0000-0002-1075-5808), Laezza D., Lombardo A. (ORCID:0000-0003-3162-1830), and Trani C. (ORCID:0000-0001-9777-013X)

Abstract

Objective: The objective of this study is to compare hemodynamic and echocardiographic findings between valve-in-valve (VIV) and native-valve (NV) patients submitted to transcatheter aortic valve implantation (TAVI) due to pure aortic regurgitation (AR). Background: Patients with severe AR are surgically treated with variable postinterventional left-ventricular (LV) “reverse remodeling.” TAVI might be considered in selected AR patients. Methods: Twenty-eight patients with pure severe AR caused by either degenerated bioprosthesis or NV disease were successfully treated by TAVI at our institution. LV catheterization before and after TAVI and echocardiography before, after (24–72 h), and at follow-up (3–12 months) were performed. Results: Baseline clinical, hemodynamic, and echocardiographic characteristics were comparable between the two study groups, except for a younger age, higher proto-diastolic LV pressure, and higher LV end-systolic diameter in the NV group. At catheterization, an immediate hemodynamic impact of TAVI in both groups was noticed, with a trend toward better postprocedural residual regurgitation index and significantly lower LV dP/dT values (666.0 ± 177.9 vs. 883.5 ± 259.7 mmHg/s, p = 0.04) in VIV. At echocardiography, both NV and VIV patients showed favorable (early and sustained) post-TAVI echocardiographically detectable reverse remodeling. VIV patients also showed more pronounced early reduction in indexed LV end-diastolic volume (68.1 ± 27.4 vs. 86.5 ± 28.9 ml/m2 in VIV, p < 0.001 and 81.0 ± 29.0 vs. 95.2 ± 37.8 ml/m2 in NV, p = 0.043). Conclusions: Successful TAVI induces a striking hemodynamic impact with major structural (reverse remodeling) consequences in patients with pure AR caused by both bioprosthesis degeneration or NV disease. In the immediate postrelease phase, VIV patients might exhibit a more pronounced early LV contractile and structural benefit.

Published
2022

9. Right ventricle systolic function and right ventricle-pulmonary artery coupling in patients with severe aortic stenosis and the early impact of TAVI

Author

Lillo, Rosa, Graziani, Francesca, Ingrasciotta, Gessica, Przbybylek, B., Iannaccone, Giulia, Locorotondo, Gabriella, Pedicino, Daniela, Aurigemma, Cristina, Romagnoli, Elisa, Trani, Carlo, Lanza, Gaetano Antonio, Lombardo, Antonella, Burzotta, Francesco, Massetti, Massimo, Lillo R., Graziani F. (ORCID:0000-0002-4520-5689), Ingrasciotta G., Iannaccone G., Locorotondo G., Pedicino D., Aurigemma C., Romagnoli E., Trani C. (ORCID:0000-0001-9777-013X), Lanza G. A. (ORCID:0000-0003-2187-6653), Lombardo A. (ORCID:0000-0003-3162-1830), Burzotta F. (ORCID:0000-0002-6569-9401), Massetti M. (ORCID:0000-0002-7100-8478), Lillo, Rosa, Graziani, Francesca, Ingrasciotta, Gessica, Przbybylek, B., Iannaccone, Giulia, Locorotondo, Gabriella, Pedicino, Daniela, Aurigemma, Cristina, Romagnoli, Elisa, Trani, Carlo, Lanza, Gaetano Antonio, Lombardo, Antonella, Burzotta, Francesco, Massetti, Massimo, Lillo R., Graziani F. (ORCID:0000-0002-4520-5689), Ingrasciotta G., Iannaccone G., Locorotondo G., Pedicino D., Aurigemma C., Romagnoli E., Trani C. (ORCID:0000-0001-9777-013X), Lanza G. A. (ORCID:0000-0003-2187-6653), Lombardo A. (ORCID:0000-0003-3162-1830), Burzotta F. (ORCID:0000-0002-6569-9401), and Massetti M. (ORCID:0000-0002-7100-8478)

Abstract

Few data are available on the prevalence of right ventricle (RV) systolic dysfunction, assessed including RV strain, and RV to pulmonary artery (PA) coupling in patients with aortic stenosis (AS) submitted to TAVI and the early effect of the procedure. We performed standard and speckle tracking echocardiography in 80 patients with severe AS the day before TAVI and within 48 h after TAVI. In all patients we measured TAPSE/PASP (cut-off for RV-PA uncoupling 0.31) and in 60/80 we were able to analyze RV global longitudinal strain (RV-GLS) and RV free wall strain (RV-FWS). RVFAC and TAPSE were impaired in 8.3% while RV-GLS and RV-FWS in 45% and 33.3% respectively before TAVI. TAPSE/PASP < 0.31 was documented in 7/80 patients (8.7%) before TAVI. These subjects differed from patients with TAPSE/PASP ≥ 0.31 for: enlarged left ventricular (LV) end-diastolic and end-systolic volumes (p < 0.001), worst LV ejection fraction (p < 0.001) and RVFAC (p < 0.001), worst RV-GLS and RV-FWS (p = 0.01 and p = 0.03) and bigger right atrium (RA) area (p < 0.001). After TAVI, RV systolic function did not improve while PASP significantly decreased (p = 0.005) driving the improvement of TAPSE/PASP (p = 0.01). Patients with TAPSE/PASP improvement (51%) differed from the others for worst pre-TAVI diastolic function (E/eʹ p = 0.045), RVFAC (p = 0.042), RV-GLS (p = 0.049) and RA area (p = 0.02). RV-GLS unveils RV systolic dysfunction in as much as 45% of patients with AS vs only 8.3% revealed by conventional echocardiography. RV systolic function does not significantly improve early after TAVI while RV-PA coupling does. Patients with lower TAPSE/PASP at baseline have worst LV and RV systolic function as well as larger RA. Patients who improve TAPSE/PASP after TAVI are those with worst diastolic function, RV systolic function and larger RA at baseline.

Published
2022

10. Acute hemodynamic impact of transcatheter aortic valve implantation in patients with severe aortic stenosis

Author

Graziani, F, primary, Cialdella, P, additional, Lillo, R, additional, Locorotondo, G, additional, Genuardi, L, additional, Ingrasciotta, G, additional, Nesta, ML, additional, Bruno, P, additional, Aurigemma, C, additional, Romagnoli, E, additional, Calabrese, M, additional, Giambusso, N, additional, Lombardo, A, additional, Burzotta, F, additional, and Trani, C, additional

Published
2022
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12. Coronary plaque instability assessed by positron emission tomography and optical coherence tomography

Author

Galiuto, Leonarda, Leccisotti, Lucia, Locorotondo, Gabriella, Porto, Italo, Burzotta, Francesco, Trani, Carlo, Niccoli, Giampaolo, Leone, Antonio Maria, Danza, M. L., Melita, V., Fedele, Elisa, Stefanelli, Alessandro, Giordano, Alessandro, Crea, Filippo, Galiuto L. (ORCID:0000-0002-6831-479X), Leccisotti L. (ORCID:0000-0002-6000-2898), Locorotondo G., Porto I. (ORCID:0000-0002-9854-5046), Burzotta F. (ORCID:0000-0002-6569-9401), Trani C. (ORCID:0000-0001-9777-013X), Niccoli G. (ORCID:0000-0002-3187-6262), Leone A. M. (ORCID:0000-0002-1276-9883), Fedele E., Stefanelli A. (ORCID:0000-0001-8323-3798), Giordano A. (ORCID:0000-0002-6978-0880), Crea F. (ORCID:0000-0001-9404-8846), Galiuto, Leonarda, Leccisotti, Lucia, Locorotondo, Gabriella, Porto, Italo, Burzotta, Francesco, Trani, Carlo, Niccoli, Giampaolo, Leone, Antonio Maria, Danza, M. L., Melita, V., Fedele, Elisa, Stefanelli, Alessandro, Giordano, Alessandro, Crea, Filippo, Galiuto L. (ORCID:0000-0002-6831-479X), Leccisotti L. (ORCID:0000-0002-6000-2898), Locorotondo G., Porto I. (ORCID:0000-0002-9854-5046), Burzotta F. (ORCID:0000-0002-6569-9401), Trani C. (ORCID:0000-0001-9777-013X), Niccoli G. (ORCID:0000-0002-3187-6262), Leone A. M. (ORCID:0000-0002-1276-9883), Fedele E., Stefanelli A. (ORCID:0000-0001-8323-3798), Giordano A. (ORCID:0000-0002-6978-0880), and Crea F. (ORCID:0000-0001-9404-8846)

Abstract

Background: Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) are caused often by destabilization of non-flow limiting inflamed coronary artery plaques. 18F-fluorodeoxyglucose (FDG) uptake with positron emission tomography/computed tomography (PET/CT) reveals plaque inflammation, while intracoronary optical coherence tomography (OCT) reliably identifies morphological features of coronary instability, such as plaque rupture or erosion. We aimed to prospectively compare these two innovative biotechnologies in the characterization of coronary artery inflammation, which has never been attempted before. Methods: OCT and FDG PET/CT were performed in 18 patients with single vessel coronary artery disease, treated by percutaneous coronary intervention (PCI) with stent implantation, divided into 2 groups: NSTEMI/UA (n = 10) and stable angina (n = 8) patients. Results: Plaque rupture/erosion recurred more frequently [100% vs 25%, p = 0.001] and FDG uptake was greater [TBR median 1.50 vs 0.87, p = 0.004] in NSTEMI/UA than stable angina patients. FDG uptake resulted greater in patients with than without plaque rupture/erosion [1.2 (0.86–1.96) vs 0.87 (0.66–1.07), p = 0.013]. Among NSTEMI/UA patients, no significant difference in FDG uptake was found between ruptured and eroded plaques. The highest FDG uptake values were found in ruptured plaques, belonging to patients with NSTEMI/UA. OCT and PET/CT agreed in 72% of patients [p = 0.018]: 100% of patients with plaque rupture/erosion and increased FDG uptake had NSTEMI/UA. Conclusion: For the first time, we demonstrated that the correspondence between increased FDG uptake with PET/CT and morphology of coronary plaque instability at OCT is high.

Published
2021

15. Early Hemodynamic and Structural Impact of Transcatheter Aortic Valve Replacement in Pure Aortic Regurgitation

Author

Graziani, Francesca, Mencarelli, E., Burzotta, Francesco, Paraggio, L., Aurigemma, Cristina, Romagnoli, Elisa, Pedicino, Daniela, Locorotondo, G., Lombardo, Antonella, Leone, Antonio Maria, Laezza, Domenico, Crea, Filippo, Trani, Carlo, Graziani F. (ORCID:0000-0002-4520-5689), Burzotta F. (ORCID:0000-0002-6569-9401), Aurigemma C., Romagnoli E., Pedicino D., Lombardo A. (ORCID:0000-0003-3162-1830), Leone A. M. (ORCID:0000-0002-1276-9883), Laezza D., Crea F. (ORCID:0000-0001-9404-8846), Trani C. (ORCID:0000-0001-9777-013X), Graziani, Francesca, Mencarelli, E., Burzotta, Francesco, Paraggio, L., Aurigemma, Cristina, Romagnoli, Elisa, Pedicino, Daniela, Locorotondo, G., Lombardo, Antonella, Leone, Antonio Maria, Laezza, Domenico, Crea, Filippo, Trani, Carlo, Graziani F. (ORCID:0000-0002-4520-5689), Burzotta F. (ORCID:0000-0002-6569-9401), Aurigemma C., Romagnoli E., Pedicino D., Lombardo A. (ORCID:0000-0003-3162-1830), Leone A. M. (ORCID:0000-0002-1276-9883), Laezza D., Crea F. (ORCID:0000-0001-9404-8846), and Trani C. (ORCID:0000-0001-9777-013X)

Abstract

N/A

Published
2020

16. Successful Transcatheter Treatment of Left Pulmonary Artery to Left Atrium Communication Diagnosed in Adulthood

Author

Lillo, R., Graziani, Francesca, Burzotta, Francesco, Locorotondo, G., Aurigemma, Cristina, Romagnoli, Elisa, Bibiana Delogu, A., Grandinetti, M., Panaioli, E., Scacciavillani, Roberto, Infusino, Fabio, Savino, G., Massetti, Massimo, Trani, Carlo, Graziani F. (ORCID:0000-0002-4520-5689), Burzotta F. (ORCID:0000-0002-6569-9401), Aurigemma C., Romagnoli E., Scacciavillani R., Infusino F., Massetti M. (ORCID:0000-0002-7100-8478), Trani C. (ORCID:0000-0001-9777-013X), Lillo, R., Graziani, Francesca, Burzotta, Francesco, Locorotondo, G., Aurigemma, Cristina, Romagnoli, Elisa, Bibiana Delogu, A., Grandinetti, M., Panaioli, E., Scacciavillani, Roberto, Infusino, Fabio, Savino, G., Massetti, Massimo, Trani, Carlo, Graziani F. (ORCID:0000-0002-4520-5689), Burzotta F. (ORCID:0000-0002-6569-9401), Aurigemma C., Romagnoli E., Scacciavillani R., Infusino F., Massetti M. (ORCID:0000-0002-7100-8478), and Trani C. (ORCID:0000-0001-9777-013X)

Abstract

Successful Transcatheter Treatment of Left Pulmonary Artery to Left Atrium Communication Diagnosed in Adulthood

Published
2020

17. Safety of antithrombotic therapy in subjects with hereditary hemorrhagic telangiectasia: prospective data from a multidisciplinary working group

Author

Gaetani, Eleonora, Agostini, Fabiana, Porfidia, Angelo, Giarretta, Igor, Feliciani, Daniela, Di Martino, Luigi, Tortora, Annalisa, Gasbarrini, Antonio, Pola, Roberto, Passali, Giulio Cesare, Riccioni, Maria Elena, Puca, Alfredo, Sturiale, Carmelo Lucio, Riccardi, L, Di Stasi, Carmine, Contegiacomo, Andrea, Del Ciello AE, Ferraro, Pietro Manuel, Cavaliere, Af, Lucci Cordisco, Emanuela, Zampino, Giuseppe, Giorgio, Valentina, Ojetti, Veronica, Marrone, G, Spoletini, G, Locorotondo, G, Lanza, Gaetano Antonio, De Candia, Erica, Peppucci, Elisabetta, Corina, Luigi, and Lombardi, Mt.

Subjects
Male, 0301 basic medicine, Pediatrics, medicine.medical_specialty, Blood transfusion, medicine.medical_treatment, Interdisciplinary Research, Settore MED/27 - NEUROCHIRURGIA, lcsh:Medicine, antithrombotic therapy, 030105 genetics & heredity, Hemoglobins, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Antithrombotic, medicine, Humans, Pharmacology (medical), Prospective Studies, Prospective cohort study, Telangiectasia, Letter to the Editor, Genetics (clinical), Aged, Hereditary Hemorrhagic Teleangectasia, antithrombotic therapy, business.industry, lcsh:R, Settore MED/09 - MEDICINA INTERNA, Autosomal dominant trait, General Medicine, Middle Aged, Hereditary Hemorrhagic Teleangectasia, Interim analysis, medicine.disease, Thrombosis, Discontinuation, Female, Telangiectasia, Hereditary Hemorrhagic, Settore MED/31 - OTORINOLARINGOIATRIA, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Subjects with the rare autosomal dominant disease Hereditary Hemorrhagic Telangiectasia (HHT) may develop medical conditions that require antithrombotic therapy (AT). However, safety of AT is uncertain in these patients and the only data currently available derive from retrospective analyses of registries and/or databases. At the HHT Centre of the ‘Fondazione Policlinico Universitario A. Gemelli IRCCS’ (Rome, Italy), a prospective study is currently ongoing to evaluate the safety of AT in subjects affected by HHT. The study is enrolling subjects with a definite diagnosis of HHT who receive an AT prescription by one of the physicians of the HHT Centre. The primary outcome is the number of hemorrhagic events, distinguished in major, clinically relevant non-major (CRNM), and minor bleedings, according to the criteria of the International Society on Thrombosis and Hemostasis (ISTH). Another primary outcome is worsening of epistaxis upon initiation of AT, assessed using the internationally accepted Epistaxis Severity Score (ESS). Additional outcomes are changes in hemoglobin levels and changes in the need of blood transfusion after initiation of AT. Here, we present the results of an interim analysis, conducted on the 12 HHT subjects that have been enrolled so far. After a mean follow-up of 6.5 ± 0.8 months, no major bleedings, no CRNM bleedings, and no minor bleedings different from epistaxis were recorded. Worsening of epistaxis upon initiation of AT was documented only in one patient, but did not require discontinuation of AT. There were no significant changes in the mean ESS measured before and after initiation of AT. There were no significant changes in hemoglobin levels and need for blood transfusion after initiation of AT. Although preliminary, these are the first prospective data on the safety of AT in HHT patients. Our interim analysis suggests that, when prescribed by experienced physicians in a multidisciplinary setting, AT is well tolerated by HHT patients. More patients and a longer follow-up are needed to confirm these findings.

Published
2019

18. Non invasive ventilation and right ventricle function in cardiogenic pulmonary edema: an echocardiographic perspective to select the "right" ventilatory support

Author

Pedicino, D, primary, Angelini, A, additional, Russo, G, additional, D"aiello, A, additional, Rocco, E, additional, Ciampi, P, additional, Ponzo, M, additional, Graziani, F, additional, Locorotondo, G, additional, Sanna, T, additional, Rebuzzi, AG, additional, Lombardo, A, additional, Massetti, M, additional, Liuzzo, G, additional, and Crea, F, additional

Published
2021
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20. Non-invasive haemodynamic assessment

Author

Kallmeyer, Andrea, primary, Zamorano, José Luis, additional, Locorotondo, G, additional, Garbi, Madalina, additional, Diego, José Juan Gómez de, additional, and Fernández, Miguel Ángel García, additional

Published
2011
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21. P1590 Regional differences in longitudinal strain and response to adenosine stress in patients with myocardial infarction and ST-segment elevation. Results from Extreme trial

Author

Manfredonia, L, primary, Locorotondo, G, additional, Graziani, F, additional, Ravenna, S E, additional, Ruscio, E, additional, Filice, M, additional, Ingrasciotta, G, additional, Palma, F, additional, Addamo, E, additional, Lombardo, A, additional, Lanza, G A, additional, and Crea, F, additional

Published
2020
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24. Diagnostic role of echocardiography in patients admitted to the emergency room with suspect no-ST-segment elevation acute myocardial infarction

Author

Manfredonia, L, Lanza, Gaetano Antonio, Crudo, Fabrizio, Lamendola, P, Graziani, Francesca, Villano, Antonio, Locorotondo, G, Melita, V, Mencarelli, E, Pennestri, F, Lombardo, Antonella, De Vita, Antonio, Ravenna, Se, Bisignani, Antonio, and Crea, Filippo

Subjects
Adult, Male, Non-ST-segment elevation acute myocardial infarction, Age Factors, Myocardial Infarction, Coronary Artery Disease, Middle Aged, Coronary Angiography, Prognosis, Coronary Vessels, Troponin, Angina Pectoris, Electrocardiography, Sex Factors, Troponin T, Echocardiography, Risk Factors, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Feasibility Studies, Humans, Female, Prospective Studies, Emergency Service, Hospital, Aged
Abstract

We investigated whether echocardiography may help identify, among patients admitted with a suspect of non-ST-segment elevation acute myocardial infarction (NSTEMI), those with athero-thrombotic coronary artery disease (CAD).We studied consecutive patients admitted with a clinical suspect of first NSTEMI. Echocardiography was assessed within 24 hours from admission. Patients were divided into two groups, according to the results of coronary angiography: 1) patients with obstructive stenosis (≥ 50%) and/or images of thrombosis in one or more coronary arteries (CAD group); 2) patients with no evidence of obstructive coronary arteries (NOCAD group).Of 101 patients enrolled in the study, 53 (52.5%) showed obstructive CAD and 48 (47.5%) NOCAD. At echocardiographic examination, regional wall motion abnormalities were found in 52.8% of patients in the CAD group and 43.7% in the NOCAD group (p=0.43). Left ventricle ejection fraction was 56.4±6.8 vs. 54.7±9.8% (p=0.30) and wall motion score index was 1.16±0.26 vs. 1.21±0.32 (p=0.39) in the two groups, respectively. A multivariable logistic regression independent predictors of obstructive CAD included age, male gender, typical angina, diabetes and hypertension.Our data showed that, in patients with acute chest pain and increased serum troponin T concentration, routine standard echocardiography does not significantly improve the diagnostic accuracy for the presence of obstructive CAD.

Published
2019

26. Parietaria pollen allergens

Author

Colombo, P., Duro, G., Costa, M. A., Izzo, V., Mirisola, M., Locorotondo, G., Cocchiara, R., and Geraci, D.

Published
1998

28. Cardiac MR

Author

Galiuto, L, Locorotondo, G, and Fedele, E

Published
2012

29. La RM cardiaca

Author

Galiuto, L and Locorotondo, G

Subjects
risonanza magnetica cardiaca, cardiomiopatia, medicina dello sport
Published
2011

33. Images in cardiovascular medicine. Intramyocardial spontaneous hematoma mimicking an acute myocardial infarction

Author

Galiuto, L, Natale, L, Locorotondo, G, Barchetta, S, Mastrantuono, Mg, Rebuzzi, Ag, Bonomo, L, and Crea, F

Subjects
Hematoma, Acute Myocardial Infarction, Aged, 80 and over, Diagnosis, Differential, Male, Heart Diseases, Echocardiography, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Myocardial Infarction, Contrast Media, Humans, Magnetic Resonance Imaging
Published
2007

34. Characterization of microvascular and myocardial damage within perfusion defect area at myocardial contrast echocardiography in the subacute phase of myocardial infarction

Author

Galiuto, L., primary, Locorotondo, G., additional, Paraggio, L., additional, De Caterina, A. R., additional, Leone, A. M., additional, Fedele, E., additional, Barchetta, S., additional, Porto, I., additional, Natale, L., additional, Rebuzzi, A. G., additional, Bonomo, L., additional, and Crea, F., additional

Published
2011
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35. Poster session IV * Friday 10 December 2010, 14:00-18:00

Author

Mora, B., primary, Base, E., additional, Schmid, W., additional, Andreas, M., additional, Weber, U., additional, Junreitmaier, M., additional, Foerster, F., additional, Hiesmayr, M., additional, Tschernich, H. D., additional, Guldbrand, D., additional, Goetzsche, O., additional, Eika, B., additional, Fumagalli, S., additional, Francini, S., additional, Gabbai, D., additional, Pedri, S., additional, Casalone Rinaldi, M., additional, Makhanian, Y., additional, Sollami, R., additional, Tarantini, F., additional, Marchionni, N., additional, Azcarate, P. M., additional, Castano, S., additional, Rodriguez-Manero, M., additional, Arraiza, M., additional, Levy, B., additional, Barba, J., additional, Rabago, G., additional, Bastarrika, G., additional, Rus, H., additional, Radoi, M., additional, Ciurea, C., additional, Boda, D., additional, Erdei, T., additional, Denes, M., additional, Mihalcz, A., additional, Kardos, A., additional, Foldesi, C. S., additional, Temesvari, A., additional, Lengyel, M., additional, Cameli, M., additional, Lisi, M., additional, Righini, F., additional, Ballo, P., additional, Henein, M., additional, Mondillo, S., additional, Nistri, S., additional, Galderisi, M., additional, Ballo, P. C., additional, Pagliani, L., additional, Olivotto, I., additional, Santoro, A., additional, Papesso, B., additional, Innelli, P., additional, Cecchi, F., additional, Hristova, K., additional, Katova, T. Z., additional, Kostova, V., additional, Simova, Y., additional, Nesheva, N., additional, Ivanovic, B., additional, Tadic, M. T., additional, Simic, D. S., additional, Rao, C. M., additional, Aguglia, D., additional, Casciola, G., additional, Imbesi, C., additional, Marvelli, A., additional, Sgro, M., additional, Benedetto, D., additional, Tripepi, G., additional, Zoccali, C., additional, Benedetto, F. A., additional, Mantziari, L., additional, Kamperidis, V., additional, Damvopoulou, E., additional, Ventoulis, I., additional, Giannakoulas, G., additional, Paraskevaidis, S., additional, Vassilikos, V., additional, Karvounis, H., additional, Styliadis, I. H., additional, Sonder, T. K., additional, Loegstrup, B. B., additional, Lambrechtsen, J., additional, Van Bortel, L. M., additional, Segers, P., additional, Egstrup, K., additional, Tho, A., additional, Moceri, P., additional, Bertora, D., additional, Gibelin, P., additional, Cho, E. J., additional, Choi, K. Y., additional, Kim, B. J., additional, Kim, D. B., additional, Jang, S. W., additional, Park, C. S., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, J. H., additional, Donal, E., additional, Coquerel, N., additional, Bodi, S., additional, Thebault, C., additional, Kervio, G., additional, Carre, F., additional, Daly, M. J., additional, Fairley, S. L., additional, Doherty, R., additional, Ashfield, K., additional, Kirkpatrick, R., additional, Smith, B., additional, Buchanan, J., additional, Hill, L., additional, Dixon, L. J., additional, Rosca, M., additional, O' Connor, K., additional, Magne, J., additional, Romano, G., additional, Calin, A., additional, Popescu, B. A., additional, Beladan, C. C., additional, Pierard, L., additional, Ginghina, C., additional, Lancellotti, P., additional, Bochenek, T., additional, Wita, K., additional, Tabor, Z., additional, Grabka, M., additional, Elzbieciak, M., additional, Trusz-Gluza, M., additional, Moreau, O., additional, Leclercq, C., additional, Sahlen, A., additional, Shahgaldi, K., additional, Aminoff, A., additional, Aagaard, P., additional, Manouras, A., additional, Winter, R., additional, Ehrenborg, E., additional, Braunschweig, F., additional, Bedetti, G., additional, Gargani, L., additional, Pizzi, C., additional, Sicari, R., additional, Picano, E., additional, Zhang, J., additional, Zhang, H. B., additional, Duan, Y. Y., additional, Chen, L. L., additional, Li, J., additional, Liu, L. W., additional, Zhu, T., additional, Li, H. L., additional, Su, H. L., additional, Zhou, X. D., additional, Ruiz Ortiz, M., additional, Mesa Rubio, D., additional, Delgado Ortega, M., additional, Romo Penas, E., additional, Toledano Degado, F., additional, Leon Del Pino, C., additional, Lopez Aguilera, J., additional, Villanueva Fernandez, E., additional, Cejudo Diaz Del Campo, L., additional, Suarez De Lezo, J., additional, Abergel, E., additional, Simon, M., additional, Dehant, P., additional, Bogino, E., additional, Jimenez, M., additional, Verdier, J. C., additional, Chauvel, C., additional, Albertsen, A. E., additional, Nielsen, J. C., additional, Mortensen, P. T., additional, Egeblad, H., additional, Nasr, G. M., additional, Tawfik, S., additional, Omar, A., additional, Olofsson, M., additional, Boman, K., additional, Rezzoug, N., additional, Vaes, B., additional, Degryse, J., additional, Vanoverschelde, J.-L., additional, Pasquet, A. A., additional, Poggio, D., additional, Bonadies, M., additional, Pacher, V., additional, Mazzetti, S., additional, Grillo, M., additional, D'elia, E., additional, Khouri, T., additional, Specchia, G., additional, Mornos, C., additional, Rusinaru, D., additional, Cozma, D., additional, Ionac, A., additional, Petrescu, L., additional, Rotzak, R., additional, Rosenman, Y., additional, Patterson, R. D., additional, Ratnatheepan, S., additional, Bogle, R. G., additional, Goebel, B., additional, Gjesdal, O., additional, Kottke, D., additional, Otto, S., additional, Jung, C., additional, Edvardsen, T., additional, Figulla, H. R., additional, Poerner, T. C., additional, Otsuka, T., additional, Suzuki, M., additional, Yoshikawa, H., additional, Hashimoto, G., additional, Itou, N., additional, Ono, T., additional, Yamamoto, M., additional, Osaki, T., additional, Tsuchida, T., additional, Sugi, K., additional, Wolber, T., additional, Haegeli, L., additional, Huerlimann, D., additional, Brunckhorst, C., additional, Duru, F., additional, Wu, Z. M., additional, Shu, X. H., additional, Dong, L. L., additional, Fan, B., additional, Ge, J. B., additional, Greutmann, M., additional, Tobler, D., additional, Biaggi, P., additional, Mah, M., additional, Crean, A., additional, Oechslin, E. N., additional, Silversides, C. K., additional, Giusca, S., additional, Jurcut, R., additional, Ghiorghiu, I., additional, Coman, I. M., additional, Amzulescu, M., additional, Ionescu, R., additional, Delcroix, M., additional, Voigt, J. U., additional, Piatkowski, R., additional, Kochanowski, J., additional, Scislo, P., additional, Grabowski, M., additional, Marchel, M., additional, Roik, M., additional, Kosior, D., additional, Opolski, G., additional, Maceira Gonzalez, A. M., additional, Cosin-Sales, J., additional, Dalli, E., additional, Igual, B., additional, Monmeneu, J. V., additional, Lopez-Lereu, P., additional, Estornell, J., additional, Ruvira, J., additional, Sotillo, J., additional, Stevanovic, A., additional, Toncev, A., additional, Dimkovic, S., additional, Dekleva, M., additional, Paunovic, N., additional, Toncev, D., additional, Sekularac, N., additional, Yildirimturk, O., additional, Helvacioglu, F. F., additional, Tayyareci, Y., additional, Yurdakul, S., additional, Demiroglu, I. C. C., additional, Aytekin, S., additional, Pinedo Gago, M., additional, Amat Santos, I., additional, Revilla Orodea, A., additional, Lopez Diaz, J., additional, Arnold, R., additional, De La Fuente Galan, L., additional, Recio Platero, A., additional, Gomez Salvador, I., additional, Puerto Sanz, A., additional, San Roman Calvar, J. A., additional, Yotti, R., additional, Bermejo, J., additional, Mombiela, T., additional, Benito, Y., additional, Sanchez, P. L., additional, Solis, J., additional, Prieto, R., additional, Fernandez-Aviles, F., additional, Zilberszac, R., additional, Gabriel, H., additional, Graf, S., additional, Mundigler, G., additional, Maurer, G., additional, Rosenhek, R., additional, Zito, C., additional, Salvia, J., additional, Longordo, C., additional, Donato, D., additional, Alati, E., additional, Miceli, M., additional, Pardeo, A., additional, Arcidiaco, S., additional, Oreto, G., additional, Carerj, S., additional, Hadjimiltiades, S., additional, Sianos, G., additional, Anastasiadis, K., additional, Grosomanidis, V., additional, Efthimiadis, G., additional, Parcharidis, G., additional, Yousry, M., additional, Rickenlund, A., additional, Petrini, J., additional, Gustafsson, T., additional, Liska, J., additional, Hamsten, A., additional, Eriksson, P., additional, Franco-Cereceda, A., additional, Eriksson, M. J., additional, Caidahl, K., additional, Mizia-Stec, K., additional, Pysz, P., additional, Jasinski, M., additional, Drzewiecka-Gerber, A., additional, Krejca, M., additional, Bochenek, A., additional, Wos, S., additional, Gasior, Z., additional, Tendera, M., additional, Niki, K., additional, Sugawara, M., additional, Takamisawa, I., additional, Watanabe, H., additional, Sumiyoshi, T., additional, Hosoda, S., additional, Ida, T., additional, Takanashi, S., additional, Olsen, N. T., additional, Sogaard, P., additional, Jons, C., additional, Mogelvang, R., additional, Larsson, H. B. W., additional, Goetze, J. P., additional, Nielsen, O. W., additional, Fritz-Hansen, T., additional, Sayar, N., additional, Orhan, A. L., additional, Erer, H. B., additional, Eren, M., additional, Atmaca, H., additional, Yilmaz, H. Y., additional, Cakmak, N., additional, Altay, S., additional, Terzi, S., additional, Yesilcimen, K., additional, Garcia Orta, R., additional, Moreno, E., additional, Lopez, M., additional, Uribe, I., additional, Vidal, M., additional, Ruiz-Lopez, M. F., additional, Gonzalez-Molina, M., additional, Oyonarte, J. M., additional, Lopez, S., additional, Azpitarte, J., additional, Szymanski, C., additional, Levine, R. A., additional, Zheng, H., additional, Handschumacher, M. D., additional, Tawakol, A., additional, Hung, J., additional, Le Ven, F., additional, Etienne, Y., additional, Jobic, Y., additional, Frachon, I., additional, Castellant, P., additional, Fatemi, M., additional, Blanc, J. J., additional, Tribouilloy, C., additional, Grigioni, F., additional, Avierinos, J.-F., additional, Barbieri, A., additional, Buiciuc, O., additional, Enriquez-Sarano, M., additional, Said, K., additional, Farag, A. K., additional, El-Ramly, M., additional, Rizk, H., additional, Iorio, A., additional, Pinamonti, B., additional, Bobbo, M., additional, Merlo, M., additional, Massa, L., additional, Faganello, G., additional, Di Lenarda, A., additional, Sinagra, G., additional, Margato, R., additional, Ribeiro, H., additional, Ferreira, C., additional, Matias, A., additional, Fontes, P., additional, Moreira, J. I., additional, Milan, A., additional, Puglisi, E., additional, Magnino, C., additional, Fabbri, A., additional, Leone, D., additional, Vairo, A., additional, Crudo, V., additional, Iannaccone, A., additional, Milazzo, V., additional, Veglio, F., additional, Maroz-Vadalazhskaya, N., additional, Ostrovskiy, I., additional, Imbalzano, E., additional, Saitta, A., additional, Cusma-Piccione, M., additional, Di Bella, G., additional, Nava, R., additional, Ferro, M., additional, Falanga, G., additional, Frigy, A., additional, Buzogany, J., additional, Szabados, C. S., additional, Dan, L., additional, Carasca, E., additional, Ikonomidis, I., additional, Lekakis, J., additional, Tzortzis, S., additional, Kremastinos, D. T., additional, Papadopoulos, C., additional, Paraskevaidis, I., additional, Triantafyllidi, H., additional, Trivilou, P., additional, Venetsanou, K., additional, Anastasiou-Nana, M., additional, Wierzbowska-Drabik, K., additional, Kurpesa, M., additional, Trzos, E., additional, Rechcinski, T., additional, Mozdzan, M., additional, Kasprzak, J. D., additional, Kosmala, W., additional, Kotwica, T., additional, Przewlocka-Kosmala, M., additional, Mysiak, A., additional, Skultetyova, D., additional, Filipova, S., additional, Chnupa, P., additional, Pechlivanidis, G., additional, Dimitroula, H., additional, Tsai, W.-C., additional, Liu, Y.-W., additional, Lin, C.-C., additional, Huang, Y.-Y., additional, Tsai, L.-M., additional, Park, S. M., additional, Kim, Y. H., additional, Shin, S. M., additional, Shim, W. J., additional, Gonzalez Mansilla, A., additional, Torres Macho, J., additional, Sanchez Sanchez, V., additional, Diez, P., additional, Delgado, J., additional, Borruel, S., additional, Saenz De La Calzada, C., additional, Pyxaras, S., additional, Valentincic, M., additional, Barbati, G., additional, Lo Giudice, F., additional, Perkan, A., additional, Magnani, S., additional, Palecek, T., additional, Ambroz, D., additional, Jansa, P., additional, Lindner, J., additional, Vitovec, M., additional, Polacek, P., additional, Jiratova, K., additional, Linhart, A., additional, Baskurt, M., additional, Dogan, G. M., additional, Abaci, O., additional, Kaya, A., additional, Kucukoglu, S., additional, Duszanska, A., additional, Kukulski, T., additional, Skoczylas, I., additional, Majsnerowska, A., additional, Nowowiejska-Wiewiora, A., additional, Streb, W., additional, Szulik, M., additional, Polonski, L., additional, Kalarus, Z., additional, Yerly, P. O., additional, Prella, M., additional, Joly, A., additional, Nicod, L., additional, Aubert, J. D., additional, Aebischer, N., additional, Dores, H., additional, Leal, S., additional, Rosario, I., additional, Correia, M. J., additional, Monge, J., additional, Grilo, A. M., additional, Arroja, I., additional, Fonseca, C., additional, Aleixo, A., additional, Silva, A., additional, Perez-David, E., additional, Sanchez-Alegre, M., additional, Gomez Anta, I., additional, De La Torre, J., additional, Alarcon, J., additional, Garcia Robles, J. A., additional, Lafuente, J., additional, Garcia Alonso, C. J., additional, Vallejo Camazon, N., additional, Gonzalez Guardia, A., additional, Nunez, R., additional, Bosch Carabante, C., additional, Mateu, L., additional, Gual Capllonch, F., additional, Ferrer Sistach, E., additional, Lopez Ayerbe, J., additional, Bayes Genis, A., additional, Tomaszewski, A., additional, Kutarski, A., additional, Tomaszewski, M., additional, Bramos, D., additional, Kalantaridou, A., additional, Takos, D., additional, Skaltsiotis, E., additional, Trika, C., additional, Tsirikos, N., additional, Pamboukas, C., additional, Kottis, G., additional, Toumanidis, S., additional, Aggeli, C., additional, Felekos, I., additional, Roussakis, G., additional, Kazazaki, C., additional, Lampropoulos, K., additional, Lagoudakou, S., additional, Stergiou, C., additional, Pitsavos, C., additional, Stefanadis, C., additional, Kihara, C., additional, Murata, K., additional, Wada, Y., additional, Tanaka, T., additional, Uchida, K., additional, Okuda, S., additional, Susa, T., additional, Matsuzaki, M., additional, Abrahamsson, A., additional, Gudmundsson, P., additional, Brodin, L., additional, Knebel, F., additional, Schattke, S., additional, Sanad, W., additional, Schimke, I., additional, Schroeckh, S., additional, Brechtel, L., additional, Lock, J., additional, Makauskiene, R., additional, Baumann, G., additional, Borges, A. C., additional, Moelmen-Hansen, H. E., additional, Wisloff, U., additional, Aamot, I. L., additional, Stoylen, A., additional, Ingul, C. B., additional, Estensen, M.-E., additional, Beitnes, J. O., additional, Grindheim, G., additional, Henriksen, T., additional, Aaberge, L., additional, Smiseth, O. A., additional, Gullestad, L., additional, Aakhus, S., additional, Agoston, G., additional, Moggi Pignone, A., additional, Capati, E., additional, Badano, L., additional, Moreo, A., additional, Bombardieri, S., additional, Varga, A., additional, Carrideo, M., additional, Faricelli, S., additional, Corazzini, A., additional, Ippedico, R., additional, Ruggieri, B., additional, Di Blasio, A., additional, D'angelo, E., additional, Di Baldassarre, A., additional, Ripari, P., additional, Gallina, S., additional, Kentrschynskyj, A., additional, Hylander, B., additional, Jacobson, S., additional, Pagels, A., additional, Dumitrescu, S. I., additional, Tintoiu, I., additional, Greere, V., additional, Cristian, G., additional, Chiriac, L., additional, Pinte, F., additional, Droc, I., additional, Neagoe, G., additional, Stanciu, S., additional, Voicu, V. A., additional, Kuch-Wocial, A., additional, Pruszczyk, P., additional, Szmigielski, C. A., additional, Szulc, M., additional, Styczynski, G., additional, Sinski, M., additional, Kaczynska, A., additional, Ryabikov, A., additional, Malyutina, S., additional, Halcox, J., additional, Bobak, M., additional, Nikitin, Y. U., additional, Marmot, M., additional, Barbosa, D., additional, Kiss, G., additional, Orderud, F., additional, Amundsen, B., additional, Jasaityte, R., additional, Loeckx, D., additional, Claus, P., additional, Torp, H., additional, D'hooge, J., additional, Kuhl, J. T., additional, Lonborg, J., additional, Fuchs, A., additional, Andersen, M., additional, Vejlstrup, N., additional, Engstrom, T., additional, Moller, J. E., additional, Kofoed, K. F., additional, Smith, L. A., additional, Bhan, A., additional, Paul, M., additional, Monaghan, M. J., additional, Zaborska, B., additional, Stec, S., additional, Sikora-Frac, M., additional, Krynski, T., additional, Kulakowski, P., additional, Pushparajah, K., additional, Dashwood, D., additional, Barlow, A., additional, Nugent, K., additional, Miller, O., additional, Simpson, J., additional, Valeur, N., additional, Ersboll, M. K., additional, Kjaergaard, J., additional, Greibe, R., additional, Risum, N., additional, Hassager, C., additional, Kober, L., additional, Popovic, D., additional, Nedeljkovic, I., additional, Petrovic, M., additional, Vujisic-Tesic, B., additional, Arandjelovic, A., additional, Stojiljkovic, S., additional, Jakovljevic, B., additional, Damjanovic, S., additional, Ostojic, M., additional, Agrios, I. A., additional, Bramos, D. B., additional, Skaltsiotis, H. S., additional, Takos, D. T., additional, Kaladaridis, A., additional, Vasiladiotis, N. 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Published
2010
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40. The IgE‐binding epitopes of rPar j 2, a major allergen of Parietaria judaica pollen, are heterogeneously recognized among allergic subjects.

Author

Assunta Costa, M., Duro, G., Izzo, V., Colombo, P., Mirisola, M. G., Locorotondo, G., Cocchiara, R., and Geraci, D.

Subjects
IMMUNOGLOBULIN E, ALLERGENS, ALLERGIES
Abstract

Pollen allergens are multivalent proteins that cross‐link IgE antibodies on mast or basophil cells, inducing secretion of biologic mediators, and resulting in various allergic symptoms. The IgE‐binding regions of the Parietaria judaica (Pj) pollen major allergen rPar j 2 were investigated. Twenty‐nine single sera from Pj‐allergic subjects were tested by Western blot against five recombinant peptides. At least four putative IgE‐binding epitopes were identified. The analysis of their diffusion suggested a heterogeneous IgE‐binding response. In fact, 75% of the sera reacted with peptide 1–54, 48% with peptide 48–101, 24% with peptide 1–30, 7% with peptide 29–54, and none with peptide 48–76. These five peptides were analyzed with the histamine‐release assay. Only peptide 48–101 was capable of inducing degranulation and release of histamine. These results suggest that the recombinant rPar j 2 allergen contains IgE epitopes that are heterogeneously recognized by sensitive patients, and that therefore the therapeutic approach based on the use of haptenic peptides needs a careful evaluation. [ABSTRACT FROM AUTHOR]

Published
2000
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