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1,423 results on '"Lobo, Dileep N."'

1. Nutritional Support

Author

Barrie, Jenifer, Lobo, Dileep N., Windsor, John Albert, editor, Barreto, Savio George, editor, and Phillips, Anthony Ronald John, editor

Published
2024
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7. Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient

Author

Peden, Carol J., Aggarwal, Geeta, Aitken, Robert J., Anderson, Iain D., Balfour, Angie, Foss, Nicolai Bang, Cooper, Zara, Dhesi, Jugdeep K., French, W. Brenton, Grant, Michael C., Hammarqvist, Folke, Hare, Sarah P., Havens, Joaquim M., Holena, Daniel N., Hübner, Martin, Johnston, Carolyn, Kim, Jeniffer S., Lees, Nicholas P., Ljungqvist, Olle, Lobo, Dileep N., Mohseni, Shahin, Ordoñez, Carlos A., Quiney, Nial, Sharoky, Catherine, Urman, Richard D., Wick, Elizabeth, Wu, Christopher L., Young-Fadok, Tonia, and Scott, Michael J.

Published
2023
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8. Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra- and Postoperative Care

Author

Scott, Michael J., Aggarwal, Geeta, Aitken, Robert J., Anderson, Iain D., Balfour, Angie, Foss, Nicolai Bang, Cooper, Zara, Dhesi, Jugdeep K., French, W. Brenton, Grant, Michael C., Hammarqvist, Folke, Hare, Sarah P., Havens, Joaquim M., Holena, Daniel N., Hübner, Martin, Johnston, Carolyn, Kim, Jeniffer S., Lees, Nicholas P., Ljungqvist, Olle, Lobo, Dileep N., Mohseni, Shahin, Ordoñez, Carlos A., Quiney, Nial, Sharoky, Catherine, Urman, Richard D., Wick, Elizabeth, Wu, Christopher L., Young-Fadok, Tonia, and Peden, Carol J.

Published
2023
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15. Promoter Methylation Leads to Hepatocyte Nuclear Factor 4A Loss and Pancreatic Cancer Aggressiveness

Author

Hatziapostolou, Maria, Koutsioumpa, Marina, Zaitoun, Abed M., Polytarchou, Christos, Edderkaoui, Mouad, Mahurkar-Joshi, Swapna, Vadakekolathu, Jayakumar, D'Andrea, Daniel, Lay, Anna Rose, Christodoulou, Niki, Pham, Thuy, Yau, Tung-On, Vorvis, Christina, Chatterji, Suchit, Pandol, Stephen J., Poultsides, George A., Dawson, David W., Lobo, Dileep N., and Iliopoulos, Dimitrios

Published
2024
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27. Prospective validation of five malnutrition screening and assessment instruments among medical inpatients: Secondary analysis of a randomized clinical trial

Author

Stalder, Lena, Kaegi-Braun, Nina, Gressies, Carla, Gregoriano, Claudia, Tribolet, Pascal, Lobo, Dileep N., Gomes, Filomena, Hoess, Claus, Pavlicek, Vojtech, Bilz, Stefan, Sigrist, Sarah, Brändle, Michael, Henzen, Christoph, Thomann, Robert, Rutishauser, Jonas, Aujesky, Drahomir, Rodondi, Nicolas, Donzé, Jacques, Stanga, Zeno, Mueller, Beat, and Schuetz, Philipp

Published
2022
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28. System-level policies on appropriate opioid use, a multi-stakeholder consensus

Author

Forget, Patrice, Patullo, Champika, Hill, Duncan, Ambekar, Atul, Baldacchino, Alex, Cata, Juan, Chetty, Sean, Cox, Felicia J., de Boer, Hans D., Dinwoodie, Kieran, Dom, Geert, Eccleston, Christopher, Fullen, Brona, Jutila, Liisa, Knaggs, Roger D., Lavand’homme, Patricia, Levy, Nicholas, Lobo, Dileep N., Pogatzki-Zahn, Esther, Scherbaum, Norbert, Smith, Blair H., van Griensven, Joop, and Gilbert, Steve

Published
2022
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33. Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: Secondary analysis of a randomised clinical trial

Author

Bretscher, Céline, Boesiger, Fabienne, Kaegi-Braun, Nina, Hersberger, Lara, Lobo, Dileep N., Evans, David C., Tribolet, Pascal, Gomes, Filomena, Hoess, Claus, Pavlicek, Vojtech, Bilz, Stefan, Sigrist, Sarah, Brändle, Michael, Henzen, Christoph, Thomann, Robert, Rutishauser, Jonas, Aujesky, Drahomir, Rodondi, Nicolas, Donzé, Jacques, Stanga, Zeno, Mueller, Beat, and Schuetz, Philipp

Published
2022
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34. Intra‐ and interindividual variability in fasted gastric content volume.

Author

Roelofs, Julia J. M., Camps, Guido, Leenders, Louise M., Marciani, Luca, Spiller, Robin C., Van Eijnatten, Elise J. M., Alyami, Jaber, Deng, Ruoxuan, Freitas, Daniela, Grimm, Michael, Karhunen, Leila J., Krishnasamy, Shanthi, Le Feunteun, Steven, Lobo, Dileep N., Mackie, Alan R., Mayar, Morwarid, Weitschies, Werner, and Smeets, Paul A. M.

Subjects
GASTRIC juice, DRUG solubility, BODY size, BODY mass index, BIOLOGICAL variation
Abstract

Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra‐ and interindividual variation in fasted gastric content volume (FGCV) and to determine the association with age, sex, and body size characteristics. Methods: Data from 24 MRI studies measuring FGCV in healthy, mostly young individuals after an overnight fast were pooled. The analysis included 366 participants who had up to 6 repeated measurements, with a total of 870 measurements. Linear mixed model analysis was performed to calculate intra‐ and interindividual variability and to assess the effects of age, sex, weight, height, weight*height as a proxy for body size, and body mass index (BMI). Results: FGCV ranged from 0 to 156 mL, with a mean (± SD) value of 33 ± 25 mL. The overall coefficient of variation within the study population was 75.6%, interindividual SD was 15 mL, and the intraindividual SD was 19 mL. Age, weight, height, weight*height, and BMI had no effect on FGCV. Women had lower volumes compared to men (MD: −6 mL), when corrected for the aforementioned factors. Conclusion: FGCV is highly variable, with higher intraindividual compared to interindividual variability, indicating that FGCV is subject to day‐to‐day and within‐day variation and is not a stable personal characteristic. This highlights the importance of considering FGCV when studying digestion and drug dissolution. Exact implications remain to be studied. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Peri‐operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society.

Author

El‐Boghdadly, Kariem, Levy, Nicholas A., Fawcett, William J., Knaggs, Roger D., Laycock, Helen, Baird, Emma, Cox, Felicia J., Eardley, Will, Kemp, Harriet, Malpus, Zoey, Partridge, Andrea, Partridge, Judith, Patel, Anjna, Price, Cathy, Robinson, Joyce, Russon, Kim, Walumbe, Jackie, and Lobo, Dileep N.

Subjects
POSTOPERATIVE pain treatment, MEDICAL personnel, INTENSIVE care units, LITERATURE reviews, POSTOPERATIVE pain, CONDUCTION anesthesia
Abstract

Summary: Background: Nearly half of adult patients undergoing surgery experience moderate or severe postoperative pain. Inadequate pain management hampers postoperative recovery and function and may be associated with adverse outcomes. This multidisciplinary consensus statement provides principles that might aid postoperative recovery, and which should be applied throughout the entire peri‐operative pathway by healthcare professionals, institutions and patients. Methods: We conducted a directed literature review followed by a four‐round modified Delphi process to formulate recommendations for organisations and individuals. Results: We make recommendations for the entire peri‐operative period, covering pre‐admission; admission; intra‐operative; post‐anaesthetic care unit; ward; intensive care unit; preparation for discharge; and post‐discharge phases of care. We also provide generic principles of peri‐operative pain management that clinicians should consider throughout the peri‐operative pathway, including: assessing pain to facilitate function; use of multimodal analgesia, including regional anaesthesia; non‐pharmacological strategies; safe use of opioids; and use of protocols and training for staff in caring for patients with postoperative pain. Conclusions: We hope that with attention to these principles and their implementation, outcomes for adult patients having surgery might be improved. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Challenges in Enhanced Recovery After Surgery (ERAS) research.

Author

Lobo, Dileep N., Joshi, Girish P., and Kehlet, Henrik

Subjects
*ENHANCED recovery after surgery protocol, *LENGTH of stay in hospitals, *SURGICAL complications, *CLINICAL trials, *HOSPITAL patients
Abstract

Despite the general agreement that implementation of Enhanced Recovery After Surgery (ERAS) pathways decrease hospital length of stay, a continuous challenge that has often been neglected is a procedure- and patient-specific approach. For example, asking 'Why is the patient still in hospital?' is the original premise for ERAS. Outcomes improve with increased compliance with recommended elements, but overcomplication of pathways can lead to cherry picking of elements that are convenient, resulting in 'partial ERAS'. As there are few high-quality randomised clinical trials (RCTs) that evaluate the specific role of individual preoperative, intraoperative, and postoperative elements, challenges lie ahead to identify essential ERAS elements to facilitate more widespread implementation. To achieve this goal, the balance between large RCTs and smaller detailed hypothesis-generating observational studies needs to be addressed in order to enhance knowledge and limit waste of research resources. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom.

Author

Al-Hadyan, Khaled S., Storr, Sarah J., Zaitoun, Abed M., Lobo, Dileep N., and Martin, Stewart G.

Subjects
CHOLANGIOCARCINOMA, BILIARY tract cancer, PROTEIN expression, PANCREATIC duct, THIOREDOXIN-interacting protein
Abstract

Background: Poor survival outcomes in periampullary cancer highlight the need for improvement in biomarkers and the development of novel therapies. Redox proteins, including the thioredoxin system, play vital roles in cellular antioxidant systems. Methods: In this retrospective study, thioredoxin (Trx), thioredoxin-interacting protein (TxNIP), and thioredoxin reductase (TrxR) protein expression was assessed in 85 patients with pancreatic ductal adenocarcinoma (PDAC) and 145 patients with distal bile duct or ampullary carcinoma using conventional immunohistochemistry. Results: In patients with PDAC, high cytoplasmic TrxR expression was significantly associated with lymph node metastasis (p = 0.033). High cytoplasmic and nuclear Trx expression was significantly associated with better overall survival (p = 0.018 and p = 0.006, respectively), and nuclear Trx expression remained significant in multivariate Cox regression analysis (p < 0.0001). In distal bile duct and ampullary carcinomas, high nuclear TrxR expression was associated with vascular (p = 0.001) and perineural (p = 0.021) invasion, and low cytoplasmic TxNIP expression was associated with perineural invasion (p = 0.025). High cytoplasmic TxNIP expression was significantly associated with better overall survival (p = 0.0002), which remained significant in multivariate Cox regression analysis (p = 0.013). Conclusions: These findings demonstrate the prognostic importance of Trx system protein expression in periampullary cancers. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Intra- and interindividual variability in fasted gastric content volume

Author

Roelofs, Julia J.M., primary, Camps, Guido, additional, Leenders, Louise M., additional, Marciani, Luca, additional, Spiller, Robin C., additional, van Eijnatten, Elise J.M., additional, Alyami, Jaber, additional, Deng, Ruoxuan, additional, Freitas, Daniela, additional, Grimm, Michael, additional, Karhunen, Leila J., additional, Krishnasamy, Shanthi, additional, Le Feunteun, Steven, additional, Lobo, Dileep N., additional, Mackie, Alan R., additional, Mayar, Morwarid, additional, Weitschies, Werner, additional, and Smeets, Paul A.M., additional

Published
2024
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47. Guidelines for Guidelines

Author

Daliya, Prita, Ljungqvist, Olle, Brindle, Mary E., Lobo, Dileep N., Ljungqvist, Olle, editor, Francis, Nader K., editor, and Urman, Richard D., editor

Published
2020
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50. Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization

Author

Peden, Carol J., Aggarwal, Geeta, Aitken, Robert J., Anderson, Iain D., Bang Foss, Nicolai, Cooper, Zara, Dhesi, Jugdeep K., French, W. Brenton, Grant, Michael C., Hammarqvist, Folke, Hare, Sarah P., Havens, Joaquim M., Holena, Daniel N., Hübner, Martin, Kim, Jeniffer S., Lees, Nicholas P., Ljungqvist, Olle, Lobo, Dileep N., Mohseni, Shahin, Ordoñez, Carlos A., Quiney, Nial, Urman, Richard D., Wick, Elizabeth, Wu, Christopher L., Young-Fadok, Tonia, and Scott, Michael

Published
2021
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