2,194 results on '"Loblaw A"'
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2. Elective pelvic nodal irradiation in the setting of ultrahypofractionated versus moderately hypofractionated and conventionally fractionated radiotherapy for prostate cancer: Outcomes from 3 prospective clinical trials
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Rachel M. Glicksman, Andrew Loblaw, Gerard Morton, Danny Vesprini, Ewa Szumacher, Hans T. Chung, William Chu, Stanley K. Liu, Chia-Lin Tseng, Melanie Davidson, Andrea Deabreu, Alexandre Mamedov, Liying Zhang, and Patrick Cheung
- Subjects
Ultrahypofractionation ,Stereotactic body radiotherapy ,Elective nodal irradiation ,High-risk prostate cancer ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background and purpose: Data is needed regarding the use of ultrahypofractionated radiotherapy (UHRT) in the context of prostate cancer elective nodal irradiation (ENI), and how this compares to conventionally fractionated radiotherapy (CFRT) ENI with CFRT or moderately hypofractionated radiotherapy (MHRT) to the prostate. Materials and methods: Between 2011–2019, 3 prospective clinical trials of unfavourable intermediate or high-risk prostate cancer receiving CFRT (78 Gy in 39 fractions to prostate; 46 Gy in 23 fractions to pelvis), MHRT (68 Gy in 25 fractions to prostate; 48 Gy to pelvis), or UHRT (35–40 Gy in 5 fractions to prostate +/- boost to 50 Gy to intraprostatic lesion; 25 Gy to pelvis) were conducted. Primary endpoints included biochemical failure (Phoenix definition), and acute and late toxicities (CTCAE v3.0/4.0). Results: Two-hundred-forty patients were enrolled: 90 (37.5 %) had CFRT, 90 (37.5 %) MHRT, and 60 (25 %) UHRT. Median follow-up time was 71.6 months (IQR 53.6–94.8). Cumulative incidence of biochemical failure (95 % CI) at 5-years was 11.7 % (3.5–19.8 %) for CFRT, 6.5 % (0.8–12.2 %) MHRT, and 1.8 % (0–5.2 %) UHRT, which was not significantly different between treatments (p = 0.38). Acute grade ≥ 2 genitourinary toxicity was significantly worse for UHRT versus CFRT and MHRT, but not for acute grade ≥ 3 genitourinary, or acute gastrointestinal toxicities. UHRT was not associated with worse late toxicities. Conclusion: ENI with UHRT resulted in similar oncologic outcomes to CFRT ENI with prostate CFRT/MHRT, with worse acute grade ≥ 2 GU toxicity but no differences in late toxicity. Randomized phase 3 trials of ENI using UHRT techniques are much anticipated.
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- 2024
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3. Stereotactic body radiotherapy for distant metastases to the head and neck
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Mutsaers, Adam, Abugharib, Ahmed, Poon, Ian, Loblaw, Joshua, Bayley, Andrew, Zhang, Liying, Chin, Lee, Galapin, Madette, Erler, Darby, Sahgal, Arjun, Higgins, Kevin, Enepekides, Danny, Eskander, Antoine, and Karam, Irene
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- 2024
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4. Developing and validating a simple urethra surrogate model to facilitate dosimetric analysis to predict genitourinary toxicity
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Ragu Ratnakumaran, Jonathan Mohajer, Samuel J. Withey, Douglas H. Brand, Ernest Lee, Andrew Loblaw, Shaun Tolan, Nicholas van As, and Alison C. Tree
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Surrogate ,Urethra ,Prostate radiotherapy ,Stereotactic body radiotherapy ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose: The urethra is a critical structure in prostate radiotherapy planning; however, it is impossible to visualise on CT. We developed a surrogate urethra model (SUM) for CT-only planning workflow and tested its geometric and dosimetric performance against the MRI-delineated urethra (MDU). Methods: The SUM was compared against 34 different MDUs (within the treatment PTV) in patients treated with 36.25Gy (PTV)/40Gy (CTV) in 5 fractions as part of the PACE-B trial. To assess the surrogate's geometric performance, the Dice similarity coefficient (DSC), Hausdorff distance (HD), mean distance to agreement (MDTA) and the percentage of MDU outside the surrogate (UOS) were calculated. To evaluate the dosimetric performance, a paired t-test was used to calculate the mean of differences between the MDU and SUM for the D99, D98, D50, D2 and D1. The D(n) is the dose (Gy) to n% of the urethra. Results: The median results showed low agreement on DSC (0.32; IQR 0.21–0.41), but low distance to agreement, as would be expected for a small structure (HD 8.4mm (IQR 7.1–10.1mm), MDTA 2.4mm (IQR, 2.2mm-3.2mm)). The UOS was 30% (IQR, 18–54%), indicating nearly a third of the urethra lay outside of the surrogate. However, when comparing urethral dose between the MDU and SUM, the mean of differences for D99, D98 and D95 were 0.12Gy (p=0.57), 0.09Gy (p=0.61), and 0.11Gy (p=0.46) respectively. The mean of differences between the D50, D2 and D1 were 0.08Gy (p=0.04), 0.09Gy (p=0.02) and 0.1Gy (p=0.01) respectively, indicating good dosimetric agreement between MDU and SUM. Conclusion: While there were geometric differences between the MDU and SUM, there was no clinically significant difference between urethral dose-volume parameters. This surrogate model could be validated in a larger cohort and then used to estimate the urethral dose on CT planning scans in those without an MRI planning scan or urinary catheter.
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- 2024
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5. Prostate high dose-rate brachytherapy as monotherapy for low and intermediate-risk prostate cancer: Efficacy results from a randomized phase II clinical trial of one fraction of 19 Gy or two fractions of 13.5 Gy: A 9-year update
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Hudson, John M., Loblaw, Andrew, McGuffin, Merrylee, Chung, Hans T., Tseng, Chia-Lin, Helou, Joelle, Cheung, Patrick, Szumacher, Ewa, Liu, Stanley, Zhang, Liying, Deabreu, Andrea, Mamedov, Alexandre, and Morton, Gerard
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- 2024
- Full Text
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6. Elective pelvic nodal irradiation in the setting of ultrahypofractionated versus moderately hypofractionated and conventionally fractionated radiotherapy for prostate cancer: Outcomes from 3 prospective clinical trials
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Glicksman, Rachel M., Loblaw, Andrew, Morton, Gerard, Vesprini, Danny, Szumacher, Ewa, Chung, Hans T., Chu, William, Liu, Stanley K., Tseng, Chia-Lin, Davidson, Melanie, Deabreu, Andrea, Mamedov, Alexandre, Zhang, Liying, and Cheung, Patrick
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- 2024
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7. Prostate Radiotherapy in Low-volume Metastatic Hormone-sensitive Prostate Cancer: A Network Meta-analysis
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Roy, Soumyajit, Fervaha, Gagan, Spratt, Daniel E., Sun, Yilun, Kishan, Amar U., Loblaw, Andrew, Malone, Shawn, Ong, Michael, Saad, Fred, Wallis, Christopher J.D., and Morgan, Scott C.
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- 2024
- Full Text
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8. Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
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Amos, Claire, Beaney, Katherine, Bellenger, Katharine, Brawley, Chris, Chung, Christina, Cook, Adrian, Embleton, Andrew, Forcat, Silvia, Goldstein, Cindy, Grabey, Jenna, Hague, Dominic, Herasimtschuk, Anna, Islam, Zaheer, Jovic, Gordana, Maniatis, Christos, Masters, Lindsey, Mohamed, Fatima, Morgan, Rachel, Murphy, Claire, Noor, Dipa, Parmar, Max, Patterson, Paul, Pickering, Holly, Pugh, Cheryl, Rauchenberger, Mary, Ribeiro, Helena, Roach, Carol, Seray-Wurie, Fatimah, Shaji, Preetha, Sims, Hannah, Spittle, Ben, Sydes, Matthew, Tappenden, Nancy, Tsang, Lilian, Uscinska, Barbara, Brown, Teddy, Casey, Sue, Davidson, Cathy, Dellar, Conor, Fletcher, Mandy, Meyer, Ralph, Murphy, Karen, Parulekar, Wendy, Richardson, Harriet, Richardson, Karen, Whelan, Kate, Bissett, Donald, Bonner-Shand, Shelagh, Grant, Judith, Lynch, Rory, MacDonald, Graham, McWilliam, Marie, Moir, Rachel, Rodwell, Sue, Shearer, Kirsty, Smith, Margaret, Binns, Louise, Briggs, Maxine, Brown, Simon, Casanova, Nathalie, Clark, Katy, Hartley, Jasmine, Henry, Ann, Henson, Helen, Hill, Pipa, Jeyasanger, Ganesan, McAlister, Judy, Parkinson, Sharron, Shaw, Alison, Alcock, Christopher, Brady, Joanne, Camilleri, Philip, Carpenter, Janice, Hogbin, Emma, Hyde, Katherine, Kavanagh, Roisin, Ngumo, Alice, Padilla-Harris, Cheryl, Panakis, Niki, Pwint, Thinn, Sabharwal, Ami, Stammers, Tracey, Stone, Helena, Varley, Gail, Weaver, Andrew, Wynn, Hazel, Allan, Elaine, Ansari, Jawaher, Cannon, Philip, Carruthers, Ross, Coubrough, Claudia, Cowan, Chloe, Glen, Hilary, Graham, Janet, Hardie, Maryon, Love, Clare, Macleod, Nicholas, Mahmood, Rana, McClements, Jane, McGlynn, Brian, McKernan, Margaret, Mcleod, Nick, Othman, Aqilah, Ross, Kristy, Roxburgh, Patricia, Templeton, Maureen, Tufail, Aisha, Turley, Claudia, Wilson, Mark, Ali, Zulfiqer, Andrews, Kelly, Burns, Rebecca, Butterworth, Caryl, Coventry, Thomas, Evans, Angela, Jones, Gareth, Lewis, Sion, Oommen, Nikhil, Owen, Susan, Saxton, Wendy, Tapping, Sister Hayley, Thomas, Dianne, Thomas, Rachel, Walker, Beth, Williams, Rachel, Collard, Susan, Ford, Victoria, Goodhind, Frances, Holbrook, Becky, Kershaw, Elizabeth, Ley, Samantha, Martinez, Maria, McCormack, Anne, Sheehan, Denise, Toy, Elizabeth, Van-Koutrik, Lynne, Varughese, Mohini, Aitken, Katherine, Barlow, David, Beattie, Louise, Bownie-Mukumbu, Godfrey, Bryan, Rachel, Corner, Victoria, Edwards, Abigail, Fazekasne Fulep, Adrienn, Guerrero-Urbano, Teresa, Gwilt, Julie, Happle, Liz, Jackman, Dee, Krysta, Beata, Paisey, Sangeeta, Shaffer, Richard, Smith, Jackie, Westley, Rosalyne, Yusof, Hilawati, Appleby, Rowan, Avis, Joanne, Beresford, Mark, Brydon-Hill, Ruth, Cox, Christine, Curtis, Samantha, Elwell, Christine, Frim, Olivera, Hamilton, Beatrice, Hudson, Zoe, Jenner, Abigail, Mantle, Mark, Mason, Jessica, Masson, Susan, McFarlane, Jonathan, Newman, Hugh, Pocock, Abigail, Robertson, Bryony, Tomlinson, Eve, Wassall, Rebecca, Williams (Née Allen), Sister Tania, Brown, Grace, Clarke, Peter, Cole, Aiden, Cousins, Jane, Gilchrist, Gail, Hagan, Chris, Hanna, Emma, Harney, Jackie, Hetherington, Stacey, Houghton, Fionnuala, Hynds, Sharon, Jain, Suneil, Johnston, Ruth, Keane, Patrick, Lyons, Ciara, McAleese, Jonathan, McAllister, Jo, McKenna, Karen, Mitchell, Darren, Murray, Stacey, O'Sullivan, Joe, Rajan, Nambi, Shum, Poh Lin, Stewart, David, Stranex, Stephen, Totten, Grace, Chandrashekara, Madhura, Drew, Ellen, Drew, Mary (Ellen), Fletcher, Julie, Gamble, Tina, Lokes, Rachel, Schumacher, Ann, Shetty, Kavitha, Sohanpal, Sundip, Whitehouse, James, Zarkar, Anjali, Ford, Daniel, Glaholm, John, Lenton, Daniel, O'Beney, Rachael, Taylor, Helen, Thomas, Helen, Chetiyawardana, Samantha, Doherty, A, El-Modir, Ahmed, Gunn, Melanie, James, Nicholas, Kedge, Liz, Mannan, Aliyah, Marange, Josephine, Morrison, Andrew, Okubanjo, Maryanne, Olaniyi-Oduntan, Darlletta, Peterkin, Zhane, Preece, George, Qureshi, Zayn, Ross, Liliam, Samra, Tarandip, Southgate, Elizabeth, Stephens, Rebekah, Stevenson, Robert, Watson-Jones, Phillip, Abdulwahid, Danya, Ainsworth, Sarah, Ashworth, Sue, Beard, Karen, Charnley, Natalie, Desai, Parth, Fielding, Bethany, Flaherty, Jan, Forrest, Diane, Frankland, Helen, Haidar, Imran, Hargreaves, Jeanette, Henry, Joanne, Hugill, Angela, Jewers, Karen, Keith, Sarah, Kilroy, Stephen, King, Jennifer, Parikh, Omi, Riley, Karen, Ryan-Smith, Janet, Thomas, Jacqueline, Thompson, Catherine, Tickle, Vivienne, Waring, Lynsey, Wise, Marcus, Dawson, Louise, Ditchfield, Julie, Al-Samarraie, Amir, Bolger, Annette, Davies, Llinos, Flavin, Aileen, Heron, Jane, Hughes, Faye, Jackson, Kim, Lewis, Joanne, Manley, Rachel, Rutter, Charley-Anne, Smith, Nick, Srinivasan, Vaiku, Stockport, Jane, Thomas, Heather, Toussi, H, Wood, Cathryn, Archer, Simon, Fletcher, Joanne, Ginnelly, Helen, Kirkby, Amy, Knight (n. Sherburn), Victoria, Lawrence nee Palmer, Tara, Mashegede, Beverley, Metcalf, Karen, Panades, Miguel, Sreenivasan, Thiagarajan, Szymiczek, Kinga, Thomas, Isobel, Young, Anita, Broadley, Eve, Brock, Sue, Davies, Joseph, Jones, Stephanie, McCully, Ruby, Naraine, Nicky, Preece, Kate, Purandare, Laura, Rabbi, Taslima, Savage, Sarah, Vamplew, Luke, Bamford, Linda, Benton, Richard, Cotterill, Lauren, Inman, Hayley, Karsera, Louise, Kay, Anne Marie, Kenyon, Lucille, Lazarte, Jannika, McNulty, Dawn, Moore, Eleanor, Nallathambi, Chandran, Naylor, Deirdre, Owen, Lisa, Parikh, Shefali, Pendrill, Amy, Price, Joanne, Robertshaw, Helen, Rodda, Sree, Sewell, Jane, Teo, Mark, Waldron, Eleanor, Bloomfield, David, Blythe, Tracy, Brown, Joanne, Carr, Philippa, Chambers, Carla, Dlodlo, Jessica, Frattaroli, Paul, Gilbert, Duncan, Hart, Andrew, Hodges, Samantha, Hooper, Simon, Hunter, Catherine, Lactao, Ranee, Leitao, Madalena, McKinna, Fiona, Nikapota, Ashok, Peterson, Jane, Robinson, Angus, Tremlett, Jean, Webb, Andrew, Wilkins, Marie, Young, Bobbie, Bahl, Amit, Baxter, Matt, Bowers, Dawn, Challipalli, Amarnath, Coe, Marc, Cowley, Sue, Gillatt, David, Griffiths, Dorothy, Henson (nee Savidge), Verity, Hilman, Serena, Hollister, Robert, Kisanga, Mary, Lee, Vivienne, Lowe, Amelia, Macefield, Rhiannon, Pegler, Ruth, Robertson, Peter, Saldanha, Helen, Simmonds, Mary, Sims, Laura, Wheeler, Lucie, Wilson, Paula, Woods, Martin, Yarrow, Sue, Zelley, Sarah, Abd Alazeez, Mohamed, Alderton, Kate, Brain, Carol, Chilcott, Helen, Clarke, Samantha, Cobos-Arrivabene, Marta, Corderoy, Helen, Cousins, Rebecca, Garner, Victoria, Herbert, Chris, Johnson, Lyndsey, Jones, Kathryn, Kemp, Gail, Kirkby, Sarah, Kirkpatrick, Suriya, Koupparis, Anthony, Manning, Courtney, Oxley, Jon, Perry, Emily, Persad, Raj, Phipps, Charlotte, Richmond-Russell, Kerry, Rowe, Edward, Shelton, Luke, Shiridzinomwa, Constance, Smith, Carolyn, Treasure, Ann, Wyatt, Clare, Beesley, Katherine, Benson, Richard, Couch, Ellie, Foxwell, Sue, Goss, Vanessa, Harnwell, Juliette, Hughes-Davies, Luke, Joslin, Vicky, Laubscher, Angelique, Mazhar, Danish, Patterson, Helen, Raj, Sanjay, Ramanujachar, Ramya, Rimmer, Yvonne, Robinson, Nicola, Russell, Simon, Stone, Matthew, Thomas, Robert, Treeby, Jo, Vickery, Kathryn, Woodward, Cathryn, Ahmed, Ilyas, Appleby, Bonny, Brulinski, Patryk, Buckley, Julie, Catt, Natalie, Coppins, Helen, Crawford, Sister Denise, Davies, Julie-Ann, Drakeley, Susan, Edwards, Albert, Evans, Clary, Galante, Joao, Gladwell, Louise, Gough, Jessica, Hargreaves, Carolyn, Hegarty, Gemma, Kehoe, Laura, Larkins, Rachel, Lipsham, Margaret, Little, Jessica, Malde, Rohit, Middleton, Sharon, Mikropoulos, Christos, Mirza, Arafat, Mithal, Natasha, Nathan, Kannon, Raman, Rakesh, Rendall, Alice, Robinson, Karen, Ryan, Rachel, Sim, Van, Swann, Michelle, Tasker, Lorraine, Taylor, Katy, Thomas, Carys, Trigonis, Ioannis, Walker, Karen, Williams, Joanne, Williamson, Elizabeth, Wood, Marian, Wood, Pauline, Zurakovsky, Hilary, Bois (nee Harris), Elizabeth, Chan, Hin Fan, Chikopela, Loveness, Clark, Helen, Clements, Colette, Holliday, Samantha, Hughes, Owen, Jones, Clare, Kynaston, Howard, Mason, Malcolm, Narahari, Krishna, Pearse, Kevin, Staffurth, John, Austin, Mandy, Barnett, Christian, Camburn, Sister Tracey, Dawson, Elizabeth, Gibson, Sian, Hamid, Abdel, Kancherla, Kiran, Leone, Priscilla, Perkins, Lauren, Ramsay, Valerie, Singizi, Bryan, Allen, Julie, Anderson, Susan, Andrews (nee Moore), Eleanor, Bakawala, Rehana, Beazer, Sarah, Binks, Colin, Bowen, Jo, Broomfield, Barbara, Cook, Audrey, Crossley, Lin, Ford, Chris, Forkes, Janet, Hall, Julia, Healey-Mariano, Jennifer, Jenkins, Peter, Johnson, Nigel, Jonnada, Sai, Owen, Roger, Pratten, Elaine, Sayers, Rachel, Shimell, Chris, Skelton, Amy, Tan, Matthew, Trigg-Hogarth, Kate, Wronski, Sue, Aldous, Mary, Archer, Denise, Eccleson, Helen, Gallimore, Elizabeth, Green, Sue, Ibrahim, Azman, Jones, Carys, Prince, Jude, Chrystal, Melanie, Din, Omar, Firth, Alexandra, Ford, Nicky, Kirkbride, Peter, Martindale, John, Redfearn, Alison, Smedley (nee McCabe), Janine, Smith, Lucy, Sorice, Vittoria, Stevenson, Lesley, Toms, Julie, Wood, Sister Kim, Barke, Nyssa, Basu, Devy, Dewar, Lorna, Driscoll, Celine, Hunting, Liz, Kumar, Muthar, Mabelin, Louies, Sizer, Bruce, Thorogood, Lucy, Askew, Sarah, Beech, Darren, Broom, Jane, Duley, Emma, Firth, Elizabeth, Gould, Aaron, Hocking, Christopher, Johns, Louise, Kent, Emma, Madine, John, Partridge, Kerena, Penhaligon, Corrine, Pentecost, Catherine, Pollard, Kay, Poultney, Melissa, Pynsent, William, Skewes, Johanna, Steele, Anita, Thomson, Alastair H, Topps, Alice, Townley, Luke, Wheatley, Duncan, Brown, Maggie, Chan, Andrew, Connor, Marie, Elwell, Sue, Geraghty, Kerry, Griffiths, Theresa, Hayward, Lesley, Humber, Caroline, Khan, Yakhub, Lake, Sister Judith, Laverick, Rosaleen, Mansell, Gemma, Mislang, Albert, Ngwenya, Su, Panesar, Pritpal, Sanders, Kay, Simmons, Elaine, Sinfield, Melanie, Stanley, Laura, Steventon, Emily, Stockdale, Andrew, Sunny, Manju, Thind, Manreet, Tranter, Fiona, Tsalic, Medy, Worlding, Jane, Adamson, Vanessa, Bennion, Carole, Butler-Barnes, Jenny, Hough, Adele, Hough, Chris, Hughes, Joanne, Irwin, P, Javle, P, Logue, John, Mansfield, Carolyn, Smith, Rachel, Sumner, Lesley, Tomlinson, Annabel, Tran, Anna, Walker, Caroline, Wylie, James, Chakraborti, Prabir, Das, Prantik, Ennis, Dawn, Marriott, Sue, Muthukumar, Dakshinamoorthy, Pattu, Pugazhenthi, Ward, Colin, Alzouebi, Mymoona, Burlace, Barbara, Ferguson, Catherine, Hooton, Georgia, Jeffcutt, Nicole, Neal, Amy, Pezaro, Carmel, Sivoglo, Virgil, Taylor, Jennifer, Wilkinson, Nicola, Afzal, Naveed, Anderson, Beverley, Andrews, Stephen, Bakker, Piet, Breakspear, Sally, Cornaby, Andrew, Crellin, Perric, Gibbins, Andrew, Gibbins, Jackie, Glen, Tracy, Goodsell, Josie, Horton, Sarah, Love, Sally, Masters, Benjamin, Rees, Andrew, Sharpe, Simon, Taylor, Kate, Wignall, Suzy, Harrow, Sister Kath, Jones, Lesley, Kanyi, Karen, Keng-Koh, Pek, McGarry, Karen, Ramachandra, Prakash, Watts, Angela, Baumber, Shelley, Howard, Joanna, Jones-Skipper, Kay, Manetta, Caroline, McCrisken, Lauren, Taylor, Jo-Anne, Williams, Amanda, Clark, Alison, Clarke, Maria, Egan, Lisa, Fiddes, Kathleen, Forman, Susan, Gardiner, Fiona, Jeffrey, David, Mariappan, Param, Mayne, Barbara, McLaren, Duncan, Rogers, Brian, Woods, Catherine, Young, Douglas, Anderson, John, Baines, Kizzy, Crundwell, M, Davey, Elizabeth, Lawless, Theresa, Matkins, Ellen, McGinley, Shannon, McGrath, John, Piper, Jane, Roantree, Alison, Seath, Ingrid, Srinivasan, Rajaguru, Stott, Mark, Timmings, Katie, Webb, Claire, Al-hasso, Abdulla, Barwell, Lorraine, Dodds, David, Finnegan, Niall, Griffen, Ailsa, Jones, Rob, Lawless, Claire, MacMillan, Antonia, Russell, Martin, Sadozye, Azmat, Shirley, Sian, Sidek, Norma, Wallace, Jan, Akhtar, Naeem, Bell, Karen, Humpreys, Louise, McWilliam, Donna, Moody, Emma, O'Neil, Rebecca, Peck, Suzannah, Auladin, Raidah, Bird, Stephanie, Bissa, Caterina, Dabbs, Marianne, Di Maria, Fabio, Goh, Chee, Harding, Joshua, Jamieson, Ceri, Jones, Jules, Khaksar, Sara, Laing, Robert, Matthews, Laura, Medisetti, Aruna, Molony-Oates, Barbara, Money-Kyrle, Julian, Nobes, Jenny, Rabsztyn, Weronika, Sidi, Frances, Smale, Daisy May, Stone, Sarah, Tindall, Annie, Woods, Jane, Wu, Min, Daniel, Amelia, Holmes, Evelyn, Kellaway, Joanne, Lewis, Amanda, Light, Teresa, Melcher, Lucinda, Robinson, Lily, Staines, Nikki, Carini, Serrafina, Cooper, Sophie, Evans, Melanie, Follows, Josh, Grant, Warren, Hedges, Andy, Hughes, Claire, Jones (Birch), Janine, King, Lisa, Lees, Laura, Mercer, Lily, Myles, Sophie, Roberts, Zara, Williamson, Nicola, Abbassi, Sara, Alonzi, Roberto, Anyamene, Nicola, Bici, Julia, Collins, Lucy, Dickson, Jeanette, Garrido-Perez, Sandra, Hoskin, Peter, Hughes, Robert, Jenkins, Suzanne, Kowalewska, Paulina, Milner, Jessica, Mitchell, Lesley, Ostler, Peter, Rashid, Aamna, Stapleton, Stephanie, Bashir, Faheem, Bone, Linzi, Clark, Diane, Dixit, Sanjay, Horne, Rhian, Jones, Dawn, Palmer, Sarah, Plowman, Kristian, Rawlings, Julie, Simms, Matthew, Addison, Anglise, Arnott, Seonaid, Borgaonkar, Sudhir, Brown, Sandra, Campbell, Audrey, Colligan, Steve, Cormack, Margaret, Doughty, Victoria, Kelly, Kay, Lister, Debbie, Macdonald, Alison, Macgregor, Carol, Mackay, Rachel, Madeleine, Jude, McNally, Morag, McPhail, Neil, Neville, Sean, Nicholls, Alison, Papakostidi, Aristoula, Simpson, Georgina, Sinclair, Glenda, Skene, Anna, Telfer, Sheena, Urquhart, Zoe, Whillis, David, Etheridge, Charlotte, Ford, Amanda, Ridley, Paul, Scrase, Christopher, Upson, Susan, Venkitaraman, Ramachandran, Capaldi, Lisa, Churn, Mark, Higgins, Linda, Knott, Helen, Stringer (pr. Davis), Sally, Taylor, Jacob, Tranter, Helen, Wollaston, Julie, Brogan (nee Roddie), Stephanie, Erskine, Susan, Hamill, Maureen, Prentice, Lynn, Symon, Lesley, Teahan, Seamus, Todd, Anne, Tweedle, James, Young, Sally, Austin (nee Glover), Gemma, Boon, Ian, Bottomley, David, Breckin, Edmund, Clarke, Jude, Coyle, Catherine, Davies, Emily, Goulding, James, Kiltie, Anne, Loughrey, Carmel, Murad, Fatima, Pratt, Claire, Shuttleworth, Pam, Smith, Beccy, Smith, Gill, Branson (née Dineen), Amy, Christmas, Sallyanne, Cooke, Jill, Griffiths, Leyshon, Kent, Christopher, King, Amy, Kockelbergh, Roger, Potterton, Janet, Speed, Lesley, Vasanthan, Subramanian, Walker, Julia, Baria, Karin, Bateman, Samantha, Coombs, Sarah, Cunningham, Amy, Dahar, Nazeer, Daruwala, Pallon, Francis, Olesya, Hall, Jane, Hoare, Kathryn, Key, Claire, Lockwood, Carol, Mark, Ian, Newton, Rachel, Sloan, Andrew, Bermingham, Nicola, Dean, Lynsey, Malik, Zafar, Pilkington, Pauline, Robson, Peter, Rogers, Heather, Rogers, Thomas, Treherne, Katy, Bourke, Amie, Chikkamuniyappa, Bindu, Dalton-Short, Ross, Edwards, Steve, Falconer, Alison, Ford, Amy, Harinarayanan, Sathish, Hassan, Nebah, Hornzee, Gillian, Magwaro, Sophia, McInerney, Sue, Pratap, Bhavesh, Rezkallah, Sarah, Sadare (Olaleye), Ibiyemi, Stancliffe, May, Stewart, Simon, Thoi, Anne-Maree, Westrop, Anna, Ahamadali, Sheefa, Arsanious, Nasr, Balogun, Shaki, Batish, Cheryl, Campbell, Yvonne, Crowley, Claire, Dunne, Emma, Ferreira, Miguel, Haldeos, Anne, Hijab, Adham, Huddart, Robert, John, Babbin, Michaelidou, Andriana, Nawrozzadeh, Mohammed, Pach, Jackie, Patel, Priyanka, Payne, Ann, Perry, Matthew, Serra, Maria, Springall, Christine, Thompson, Jane, Thomson, Sister Jane, Tree, Alison, Aya, Viviana, Beaney, Ronald, Bower, Lorna, Conway, Lisa-Jane, Donaghey, Sally, Gordon, Hussain, Grau, Isabel, Harris, Sarah, Hogan, Vesna, Hore, Brendan, Hughes, Simon, Jones, Katie, Kuenzig, Greg, Morris, Stephen, Nunney, Dawn, Rashid, Jessica, Reynolds, Philip, Rooprai, Bali, Mangar, Stephen, Azirar, Hanna, Caumont, Tom, Gupta, Nishi, Hill, Judy, Karp, Stephen, Kullane, Sagal, Macavoy, Tina, Neave, Farhad, Newby, Jackie, Van Someren, Chloe, Anderson, Naomi, Annan, Lynda, Cooke, Juniebel, Douch, Emma, Fawcitt, Sara, Gore, Alexandra, Grieve, Sylvia, Jarvis, Claire, McCadden, Angela, Needleman, Sarah, Pigott, Katherine, Powell, Hannah, Ramtohul, Kaliyanee, Rosenfelder, Nicola, Vilarino-Varela, Maria, Ali, Jennyfa, Ali, Maryam, Banda, Laillah-Crystal, Bott, Trevor, Brown, Emmanuel, Bryant, Hanna, Carlino, Giulia, Grant, Cordelia, Hogan, Holly, Khoo, Vincent, Mojidra, Chintan, Montebello, Joseph, Morrison, Jennifer, Olabanji, Matthew, Pillai, Sijy, Siu, Bernard, Stafferton, Ruth, Storrs, Sarah, Townsend-Thorn, Debra, Van As, Nicholas, Vijayakumar, Vijitha, Welsh, Liam, Dearnaley, David, Gao, Annie, Horwich, Alan, Lewington, Val, Marshall, John, Murphy, Louise, Parker, Chris, Beaton, Kirsty, Bech-Nielsen, Nanette, Bolton, Olivia, Conibear, John, Dekaj, Fatjon, Hillman, Paul, Jayachandran, Resmi, Kaliski, Alexandre, Kiff, Janet, Nicholson, Alastair, Nixon, Jude, Oladimeji, Janet, Riches, Oscar, Smith, Dan, Tipples, Karen, Wells, Paula, Anderson, Chris, Daly, Deirdre, Dover, Serena, Gilmartin, Claire, Golden, Sophie, Gregg, Jane, Issa, Rami, Oni, Titilayo, Patel, Chandni, Quarrell, Mark, Rolfe, Debbie, Tighe, Helen, Toledo, Jesusa, Tuazon, Juel, Varro, Robert, Bohra, Vikram, Caballes, Mark, Custins, Laura, Ivie, Stephanie, Joshi, Manisha, Liau, Joy, Naim, Farhan, Patel, Anup, Pathmanathan, Byiravey, Russell, Emily, Tippins, Anna, Agdiran, Didem, Aggarwal, Ajay, Amoaten, Thomas, Aslam, Natasha, Bonsu, Nicole, Butt, Zainab, Danaswamy, Patricia, Davda, Reena, Gillesen, Annelies, Goel, Roshni, Khong, Rachel, Lowi, Suzy, Merrick, Richard, Mitra, Anita, Payne, Heather, Teh, Jonathan, Whinn, Samantha, Woolf, David, Zilkha, Helene, Dawson-Athey, Linda, Foster, Emma, Gillian, Andrew, Green, James, Hines, John, Holden, Simon, Kazingizi, Memory, O'Neill, John, Olaoni, Thompson, Peters, John, Philp, Timothy, Zaidi, Sadaf, Adeyoju, Adebanji, Adinkra, Victoria, Brough, Richard, Brown, Stephen CW, Collins, Gerald, Hardstaff, Lisa, Hill, Pippa, Kujawa, Magda, McCurrie, Marilyn, Townley, Barbara, Woodhouse, Iain, Zafar, Waheed, Beesley, Sharon, Breen, Vivienne, Burrage, Su, Calvert, Clare, Davison, Alison, Dias, Heather, Fossey, Gavin, Hotine, Jodie, Jones, Ifan, Jope, Carmel, Lines, Yvonne, Martins, Sarah, Mercier, Barbara, Murray, Jane, Neshiri, Innocent, Pamphlett, Ian, Phillips, Ann, Rai, Pavnish, Roberts, Verity, Taylor, Henry, Tribe, Lisa, Bottomley, Ian, Buchan, Jonathan, Carpio, Viviana, Choudhury, Ananya, Conroy, Ruth, Cowan, Richard, Davison, Sue, Duncan, Ian, Elliott, Tony, Fair, Kim, Fallaize, Adrian, Flanagan, Laura, Green, Sarah, Harris, Catherine, Hart, Amber, Jones, Cathryn, Livsey, Jacqueline, McCaul, Damian, Nazari, Roonak, Newbery, Carol, O'Connor, Kate, O'Dwyer, Sister Jackie, Oliver, Joanne, Onoge, Ekugbe, Petsa, Maria, Redshaw, Catherine, Smith, Sarah-Ellen, Spoor, Willemijn, Thomas, Sister Viv, White, Holly, Worsley, Lucy, Bailey, Linda, Bennett, Molly, Corless, Rebecca, Duffy, Annie, Fellows, Kathryn, Gipson, Anna, Haydock, Helen, Knox, WF, Liptrott, Sarah, McCarth, Fiona, McCartin, Fiona, Mistry, Heena, Mthethwa, Thobekile, Partington, Lillian, Piper, Lindsay, Ramani, Vijay, Sahin, Sarah, Sangar, Vijay, Slevin, Kathryn, Tuck, Jonathan, Atkinson, Lorraine, Barnbrooke, Sarah, Barnes, Alison, Brownless, Caroline, Chadwick, David, Hardman, John, Harland, Keith, Long, Carol, McAuliffe, Sarah, McBride, Julia, McClurey, Sister Patricia, Mohan, Rita, Naylor, Lynne, Peedell, Clive, Robson, Paula, Shakespeare, Devadasan, Thompson, Emma, Van der Voet, Hans, Wilson, David, Barron, Chris, Frew, John, Lambert, Katy, McMenemin, Rhona, Pedley, Ian, Riseborough, Danielle, Roberts, Trevor, Stockley, Emma, Stoddart, Jonathan, Tate, Janine, Walker, Jayashree, Workman, Bridget, Barnett, Debra, Carter, Adam, Cox, Adam, Davey, Alison, Davies, Kirstin, Gilby, Lisa, Hodge, Simon, Kearney, S, Lavender, Helene, Marty, Janet, Nash, Maxine, Rahman, Syhed, Richards, Jayne, Simpson, Julie, Wall, Elaine, Webb, Paula, Wild, Karen, Wilson, Jim, Branagan, Jenny, Dell, Gillian, Foo, Maxine, Goyena, Ruby, Jones, Andrea, McBain, Hazel, McGrath, Katherine, O'Callaghan, Jane, Ramanathan, Dorai, Tee, Elizabeth, Thominson, Bronwen, Tighe (nee Bussey), Rachel, Beety, Jane, Birch, Richard, Bloomfield, Mark, Callam, Sara, Cooper, Adele, Darby, Helen, Healey, Gail, Heasley, Karen, Kapur, Guarav, London, Clare, Oosterom, Katrien, Ostrowski, Joe, Shobrook, Bridget, Turner, Sarah, Wade, Rob, Walker, Suzanne, Walton, Sharon, Websdale, Cheryl, White, Joanna, Alder, Leanne, Chivers, Rachael, Gooch, Carol, Howard, Lucy, Hutchinson, Camille, Jevons, Cody, Kumar, Daniel, Marley, Hazel, Mills, Jamie, Purves, Hanna, Sayers, Ian, Sundar, Santhanam, Szolin-Jones, Jacob, Walker, Georgina, Wood, Catherine, Cook, Wendy, Gill, Lisa, Johnson, Joanne, Johnstone, Dawn, Jones, Richard, Mistry, Leena, Scarratt, Lyndsay, Aiku, Abimbola, Ajzensztejn, Daniel, Al-Chamali, Hiba, Andrade, Gerard, Barber, Dave, Bekulart, Sylwia, Bhatnagar, Gagan, Boutflower, Jane, Brewster, Simon, Butterfield, Anne, Carroll, Weronika, Cole, David J, Coutts, Tim, Doyle, Kerrie, Durrant, Lisa, Green, Trish, Jampana, Raj, Jastrzebska, Patrycja, Kyffin, Phillippa, Langridge, Nicole, Lawrey, Sarah, Markus, Sarah, Marston, Kerrie, Mooney, Matthew, Mukkath, Sandra, Murphy, Ann, Owens, Rob, Ruane, Sarah, Sabbagh, Ahmad, Samkange, Grace, Sankighatta, Naveen, Skwarski, Michael, Stuart, Robert, Wellman, Sandie, Wilson, Jo, Cavanagh, Kerrie, Hollingdale, Abigail, Allen, Susan, Barter, Elisa, Gregory, Debbie, Ingle, Charlotte, Lawrence, Steph, Rooney, Paula-Joanne, Bishop, Emma, Brennan, Maria, Cogley, Lyn, Hammonds, John Christopher, McInerney, Paul, McLarty, Esther, Natale, Salvatore, Pascoe, Sarah, Purcell, Keith, Sells, Henry, Tyner, Sharah, yates, Victoria, Beamish, Neal, Blaney, Hilary, Clapp, Felicity, Clarke, Elizabeth, Coffin, Teresa, Davies, Joe, Downs, Nichola, Gillespie, Sally, Heckford, Louise, Iskender, Amanda, Orford, Sara, Pressdee, Sandy, Rix, Sophie, Wheelwright, Roger, Woodward, Elizabeth, Wright, Seonaid, Blight, Kathy, Dobson, Tracey, Hale, Jennifer, Harris-Burland, Angie, Khoury, Ghassan, Madhava, Kudingila, Meadows, Lorna, Nagar, Yoodhvir, Roca, Mila, Stacey, Wendy, Stephenson, Anna, Uherek, Maja, Virgo, Azarel, Watkinson, Catrin, Birtle, Alison, Chauhan, Zainab, Cornthwaite, Stephanie, Curtis, Sandra, Ellard, Rose, Fish, Nathan, Hefferon, Billy, Searle, Claire, Spickett, Helen, Walmsley, Catherine, Atkinson, Jane, Brown, Richard B, Cartwright, Debbie, Coomber, Kristy, Hunt, Allison, Kowalczyk-Williams, Wioletta, Lewis, Christina, Parr, Stephen, Purdon, Helen, Rogers, Paul, Vowell, Emma, Featherstone, Wendy, Hamilton, Joanna, Harrison, Alison, Hindle, Margaret, Hodson, Hayley, Isaew, Andrea, Knapp, Jeanette, Moss, Sarah, Gibbs, Stephanie, Gujral, Sandeep, Jannapureddy, Revanth, Kelkar, Anand, Martinou, Maria, Mills-Baldock, Tina, O'Brien, Neale, Subramaniam, Ramachandran, Tahir, Saad, Vandal, Mohammad Tanvir, Vu, Thi, Allen, Rachael, Betts, Chris, Bowmer, Amanda, Clarke, Noel, Cordwell, Amanda, Dharmaprasad, Soney, Duncan (nee Keatley), Claire, Farnworth, Christine, Farrell, Helen, George, Siny, Goulden, Kay, Harter, Leah, Kaushal, Malan, Kirk, Sister Sarah, Lau, Maurice, Lydon, Anne Marie, O'Flynn, Kieran, Platt, Danielle, Shackley, David, Stevenson, Garry, Taylor, Sister Melanie, Thompson, Chloe-Anne, Vinod, Cellins, Wadsworth, Oliver, Youd, Sister Jill, Attlee, Julie, Bhatnagar, Adityanarayan, Bunn, Sarah, Campbell, Allister, El-Saghir, Mohammed, Fennelly, Ruth, Guy, Peter, Mattocks, Lehentha, Mcintosh, Gregor, Murphy, Brenda, Reed, Catherine, Strong-Sheldrake, Sophia, Tedd, Gemma, Dent, Kathleen, Hood, Marion, Martin, Karen, Pearson, Sandra, Potoczna, Dorota, Spencer, Sue, Towse, Jo, Whotton, Nikita, Bowen, Katie, Clark, Su, Clarke, Rachael, Gibbins, Kate, Martin, Jackie, Smith, Suzanne, Spalton, Catherine, Tay, Jessica, Adams, Marion, Bates, Emma, Chennattukungu, Indukala, Clancy, Joanna, Cross, Vanessa, Hughes, Hayley, Jose, Sanal, Kurian-Downer, Sunita, Michael, Elena, Moore, Sister Helen, Nicholas, Karen, Pope, Suzanne, Potts, Sally, Prashant, Ravi, Singh, Harpreet, Smith, Sandra, Srihari, Narayanan, Weaver, Emma, Abbas, Ali, Barnes, Nicky, Dallas, Nicola, Jackson, Sister Ann, Kader, Nicole, Karim, Omer, Laniado, M, Litchfield, Jayne, Mahmood, Sana, O'Donnell, Helen, Robinson, Victoria, Sears, Alison, Sharif, Shahid, Sierra Pala, Ana, Sinclair, Julie-Ann, Smith, Sister Catherine, Ashcroft, Jan, Boardman, John, Bowes-Cavanagh, Jeanette, Brown, Rebecca, Chedham, Alison, Darch, Flora, Farrar, Michelle, Foot, Jayne, Goldsworthy, Simon, Graham, John, Gray, Emma, Green, Sara, Jelski, Joseph, Kalejaiye, Odunayo, Keni, Manjusha, Locke, Angela, Mahoney, Sue, McMeekin, Faith, Periasamy, Manivannan, Russell, Tamlyn, Ruszala, Elizabeth, Segaran, Surayne, Tighe, Mary, Wallbutton, Rebecca, Webster, Christine, Whitcher, Alison, Wiggins, Sarah, Wrigley, Martha, Zietz, Maria, Abab, Julie, Cumming, Kirsty, Galloway, Lucy, Ganabady, Malavika, Haskell, Annelise, Heath, Catherine, James, Naomi, Kennedy, Julie, McFarlane, Victoria, Morales-Azofra, Fabiola, Morton, Susan, Mundy, Carina, Noble, Mark, Paschalis, Alec, Patrick, Julie, Reader, Leanne, Taylor, Lisa, Wakefield, Shauna, Ahmed, Imtiaz, Bowman, Sue, Chan, Olivia, Cyriac, Abby, Davies, Tracey, Maitland, Katrina, Prejbisz, Jan, Reece, Sheila, Shires, Heather, Tsang, David, Anscombe, Eleanor, Brough, WA, Clitheroe, Pat, Cocks, Tracie, Connolly nee McKenna, Sarah, Corcoran, Sam, Coughlan, Tricia, Gilmour, Christina, Goodwin, Emma, Graham, Susan, Hatimy, Umi, Hodgkinson, Sheila, Kilmartin, John, Orrell, Lucy, Rotherham, Carol, Smallwood, Sarah, Taylor, Jill, Wiss, Elliott, Adab, Fawzi, Bhana, Rajanee, Dhinakaran, Kathirvelu, Evans, Marion, Myatt, Alison, Parkinson, Katrina, Peake, Angela, Sellars, Elizabeth, Smith, Rowena, Storer, Julie, Thomasson, Georgia, Vengalil, Salil, Walton, Jenny, Ward, Angela, Boam, Samantha, Burgoyne, Jamie-Rae, Chadwick, Eliot, Gill, Shafiq, Haigh, Steve, Hollis, Keri, Lim, Jun, McCabe, Alastair, Munson, Lyndsey, Nash, Dominic, Saunders, Daniel, Smith, Susan, Wade, Lynne, Evans, Elizabeth, Franklin, Alex, Harris (n. Marchant), Emily, Johnstone, Maria, Jones, Lewis, Lemon, Nicola, Phan, Mau-Don, Pudney, Delia, Spence, Rachael, Stretch, Alison, Tait, Ellen, Williams, Bethan, Belcher, Rebecca, De Silva-Minor, Shiroma, Dodge, Sister Jan, Grayland, Sarah, Jones, Ania, Khan, Omar, Owen, Tim, Palmer, Debbie, Parajes, Cerila, Pegler, Suzannah, Poole, Abbie, Sargent, Sister Tracey, Starling, Ellen, Taylor, Becky, Winter, Sister Helen, Zinyemba, Vivian, Allison, Michele, Blundell, Martyn, Brookman, Catherine, Buckley, Jon, Chamberlain, Shelley, Cuffe, Donna, Davies, Stacey, Fairfax, Claire, Greedus, Helen, Griffin, Hannah, Koehler, Ingrid, Lydon, Anna, Michels, Jorg, Pym, Julia, Roberts, Fiona, Thornton, Lorraine, Vandecandalaere, Elaine, Watts, Erica, Welsh, Linda, Anderson, Jim, Anderson, Juliette, Ball, Julie, Benton, Louise, Bowers, Richard, Chahal, Rohit, Dickinson, Peter, Fosker, Chris, Heeley, Janine, Kanaga-Sundaram, Subramanian, Littler, Stephen, Slack, Jonathan, Sundaram, Subramanian Kanaga, Taylor, Beverley, Weston, Philip, Chettle, Judith, Hartwell, Lyn, Johnson-Rollings, Ashley, Jones, Julia, Millage, Helen, O'Neill, Eilish, Walsh, Donna, Webb, Kerrie, Williams, Jo, Dymond, Harvey, Eleftheriadis, Symeon, Lloyd-Jones, Hugh, Wells, Tom, Bennett, Sarah, Dunn, Sharon, Fildes, Diane, Hassall, Alison, Herbert, Gaynor, Hughes, Kathryn, Innes, Helen, Kelly, Alison, Littler, John, Lomax, Laurie, Miller, Nikki, Nutman, Chris, Stott, Matthew, Syndikus, Isabel, Tolan, Shaun, Weston, Alison, Baker, Ivanna, Carter, Vanda, Chatfield, Jenny, Cooke, Peter, Grant, Anna, Homer, David, Kirk, Christine, Lomas, Claire, McCormick, Marian, Mohseeni, Arizoo, Pawaroo, Renita, Radford, Liz, Rogers, Jason, Samanci, Ali, Sharman, Emma, Spencer, Hazel, Spruce, Debbie, Worthington, Hannah, Bak, Dagmara, Cleary, Kristy, Davies, Sue, Gauntlett, Monica, Gupta, Kamalnayan, Holdsworth, Amanda, Ledger, Kate, Morrow, Hugh, Perry, Heather, Rimell, Patricia, Rosoman, Alison, Tyler, Jayne, White, Ann, Crowe (nee Hughes), Dawn, Flynn-Batham, Marian, Folkes, Linda, Funnell, Sarah, Gilbert, Jeanette, Gomez-Marcos, Raquel, Gonzalez, Celia, Hoskins, Chloe, Moore, Sally, Plataniotis, George, Rippin, Sarah, Smith, Matthew, Tsawayo, Tan, Turner, Nikki, Wakelen, Paula, Cserbane, Anita, Fernandez, Claire, Kurup, Rahul, Manyangadze, Sarah, McLain-Smith, Susan, Protheroe, Andrew, Trewsmith, Neil, Allison, Joanna, Barron, Claire, Beaumont, Erica, Beer, Nigel, Beesley, Kate, Donaldson, David, Duckett, Tracey, Fox, Shirley, Kotze, Michelle, Kumar, Shiyam, Macrory, Joanne, Perry, Jess, Pippard, Lucy, Porter, Tim, Rennie, Kerry, Sparrow, Geoffrey, Williams-Yesson, Barbara, Balderson, Jane, Bowling, Lorna, Brittain, Paul, Brookes, Claire, Campbell, Hilary, Campos, Monica, Conway, Rachel, Davies, Flor, Donnison, Michelle, Elliott, Mark, Evans, Richard, Fallah, Fereshteh, Fearnley, Mark, Giddings, Emma, Gollapothu, Srilakshmi, Harvey, Sally, Holbrook, Andy, Ingham, Jo, Jakeman, Christine, Joseph, Joji, Mole, Lisa, Musunuru, Hima Bindu, Pashley, Sarah, Saleem, Shamila, Stower, Michael, Strider, Paula, Taylor, Carol, Thackray, Louis, Todd, Joanna, Wightman, John, Wilson, Russ, Youngs, Nora, Byrne, Mary Marg, Deenihan, Emma, Durkan, Garret, Jennings, Marian, Mahoney, Catriona, Martin, Joseph, McInerney, Veronica, Raftery, Liz, Rogers, Eamonn, Spillane, Maria, Sullivan, Frank, Teh, Chiaw Woon, Wright, Ann, Harving, Niels, Hejlesen, Finn, Kempel, Mette Moe, Steffensen, Kirsten, Bentzen, Lise, Borre, Michael, Buus, Simon, Fode, Kirsten, Kaa Bach, Birgit, Lassen, Yasmin, Laursen, Vibeke, Lemng Kruse, Helle, Lucakova, Slavka, Nørmark Iversen, Helle, Brasso, Klaus, Christensen, Anne Juel, Gruschy, Lisa, Klovgaard, Karina, Lunau, Anne Sofie, Meidhal Petersen, Peter, Moller Christensen, Trine, Poder, Lone Lund, Ribers, Kristine, Stilling, Sine, Thim, Stine, Torin Lehmann, Anna, Vandborg, Maria, Christensen, Tine, Kokholm, Kathrine Friser, Lindberg, Henriette, Nybom, Kirstine, Rønnengart, Eva, Saxe, Charlotte, Baird, Noelle, Braun, Michael W, Cheung, Arthur, Fourt, Monica, Jackson, Cathy, Jepson, Debbie, Johnson, Arlissa, Karvat, Anand, Kwan, Winkle, McIndoe, Sue, Mitchell, Donna, Sandhu, Sandeep, Serpanchy, Rosanne, Wu, Helen, Beausoleil, Rachelle, Crawford, Melanie, DiMarco, Christine, Ding, Ian, Gladwish, Adam, MacIsaac, Patricia, MarshGray, Kimberley, Morton, Gerard, Murphy, Cara, Pascoe, Caitlin, Pokhrel, Sujata, Stevens, Christiaan, Yoon, Frederick, Yu, Jason, Dubey, Arbind, Sivananthan, Gokulan, Bahary, JeanPaul, Barkati, Maroie, Beauchemin, MarieClaude, Benth, Silvine, Carbonaro, Adriana, Delouya, Guila, ElSokhn, Nidale, Frazzi, Alexandra, Lambert, Carole, Lavertu, Sophie, Menard, Cynthia, Pan, Siew Siew, Rousseau, Pierre, Saad, Fred, Taussky, Daniel, Trudel, Diane, Amanie, John Oliver, Batz, Margaret, Borynec, Carol, Danielson, Brita, Garcia, Leni Santiago, Gramlich, Colin, Lang, Monika, Larson, Beverly, Mallett, Debbie, McCrudden, Sylvia, Murtha, Albert, Parker, Shelley, Parliament, Matthew B, Patel, Samir, Pearcey, Robert, Pervez, Nadeem, Rose, Jim, Shewchuk, Caroline, Smith, Carlie, Usmani, Nawaid, Williams, Candra, Yee, Don, AlRashdan, Abdulla, Avery, Alison, Beaton, Heather, Bond, Brittany, BrucePayne, Kim, Burbridge, Susan, Bursey, Kara, Carvery, Lane, Dill, Kendra, Dugas, Stevie, Harding, Claudia, Hodder, June, Hollenhorst, Helmut, Hubley, Lynn, Joseph, Paul K, Little, Erin, MacDonald, Angela, MacIsaac, Kathy, MacVicar, Jennifer, McCracken, Jillian, Moffatt, Emily, Nieforth, Joan, Patil, Nikhilesh, Rijt, Kelsey van der, Roberts, Victoria, Rose, Tina, Rutledge, Robert DH, Salyzyn, Camryn, Simpson, Robin, Sutherland, Donna, Walker, Heather, Wilke, Derek, Yeo, Tanya, Yunace, Lorrie, Zinck, Connie, Bier, Bianca, Bucci, Catherine, Corbett, Thomas B, Dayes, Ian S, Eady, Robin, Gudelis, Susan O, Hill, Elaine, Kinrade, Yvonne, Laughlin, Anne, Lukka, Himu, Makepeace, Barbara, Marshall, Lynn, Nielsen, Linda, Oliverio, Carmela, Patel, Malti Behn, Tsakirdis, Thedoros, Wong, Jason W T, Allen, Kirsten, Bachand, Francois, Carefoot, Layton, Cotts, Shannon, Creelman, Brianna, Crook, Juanita, GeorgeChayka, Danielle, Halperin, Ross, Hartt, Nancy, Hayes, Jill A, Kim, David, Kim, TuongVan, Kronstal, Flo, Lee, Bernard, Lew, Tanya, McClelland, Marie, Opitz, Debbie, Overend, Aldyn, Reed, Melanie, Watson, Michaella, Wilkie, Karen, Winn, Carol, Yanchuk, Janet, Bonner, Scott, Brander, Mike, Brundage, Michael, Carlson, Cindy, Edwards, Jackie, ElKerdawy, Hala, Harpell, Rhonda, Hartman, Carrie, Kalyvas, Maria, KirbyBello, Denise, Kumar, Vikaash, Leach, Deborah, MacVicar, Karen, Mahmud, Aamer, Maize, Christine, Moelker, Yvonne, Murano, Abby, Paul, Nancy, Ross, Ashley, RossSmith, Marleen, Shenfield, Carey, Spencer, Craig, Tennant, Virginia, Vermette, Tracy, Willing, Stephanie, Zaza, Khaled O, Zeltser, Fred, Gearing, Jennifer, Girolametto, Carla, Gopaul, Darindra, Hamilton, Ronald, Hendel, Debra, Janke, Susan, Knackstedt, Jochen, Kuk, Joda, Morrison, MaryBeth, Mumin, Anissa, Nemirov, Stephanie, Rachakonda, Ramana, Shantz, Brenda S, Siddiqui, Atif, Thallury, Sheeba, Ahmad, Belal, Bailey, Laura, Bauman, Glenn, Camara, Mary Jane, Corkery, Danylle, DSouza, David, DiLullo, Elenor, Eichenberger, Lois, Francis, Peggy, Grant, Susan, Gratton, Albert, Gurzanski, Christina, Hare, Jennifer A, Johnson, Craig, Kenny, Shannon, Lock, Michael I, Loughlin, Kate, Mardell, Stephen, Mayer, Heather, Rodrigues, George B, Sax, Lori, Sebborn, Kes, Sexton, Tracy, Venkatesan, Varagur M, tenHaaf, Darlene, Chatelain, AnneMarie, Fortin, Jacqueline, Houle, Stefanie, Khaouam, Nader, Lachance, Nicole, Laliberte, Benoit, Lemaire, Celine, Nguyen, David H A, Sylvestre, Alma, Vavassis, Peter, Yassa, Michael, Adnaan, Jamila, Briand, Wayne, Casey, Linda, Chipman, Penny, Corwin, Charlotte, Duclos, Marie, Faria, Sergio Luiz, Ghoul, Mokhtar, Joncas, MarieClaude, Koulouris, Zoe, Larocque, Stephanie, Lee, Brenda, Olha, Carolynna, Robert, MarieFrance, Sharma, Rajesh, Shenouda, George, Souhami, Luis, Albrecht, Virginia, Froese, Jane, Froude, Nancy, Howitt, Pamela, Iqbal, Fawaad, Kift, Shannon, Koll, Wayne, Li, Audrey, MacGregor, Barbara, Manganaro, Aileen, McKee, Dianne, Mendoza, Edeliza, Mui, Jimmy, Myrehaug, Sten, Singson, Angelina, Slessor, Janet, Somasiri, Ashane, Stevens, Nicole, Berghout, Koralee, Bourque, JeanMarc, Carkner, Amy, E, Choan, Eapen, Libni, Eze, Nancy, Fish, Matt, Haddad, Alain, Hicks, Kimberly, Iordanidi, Elina, Kanji, Femina, Kendal, Wayne S, MacMullin, Lisa, MacRae, Robert M, Malone, Shawn, Morgan, Scott, Nguyen, Julie, OBrien, Anna, Page, Nancy, Perry, Gad A, Reeves, MarieClaude, Roach, Joanne, Sanchez, Maria, Spearman, Mary, Spencer, Patti, Tikoo, Archana, Turriff, Lisa, Wright, Natalie, Bedoya, Luis Diaz de, Cossette, Danielle, Cusan, Leonello, Desrosiers, Isabelle, Dufour, Nathalie, Foster, William, Gomez, JoseLuis, Hathout, Lara, Lajoie, MarieAndree, Martin, AndreGuy, Pouliot, Sophie, Vigneault, Eric, Bouchard, Myriam, Bujold, Rachel, Carmel, Michel, Cote, Genevieve, Dion, Helene, Ebacher, Annie, Gauthier, Isabelle C, Ladouceur, Cynthia, Lamoureux, Alexandra, Larouche, Julie, Marquis, Tania, Nabid, Abdenour, Pearson, Diane, Sabbagh, Robert, TetreaultLaflamme, Audrey, Baker, Erin, Blackwood, Geoffrey, Galway, Denise, Greenland, Jonathan, Hannaford, Zeta, Hoskins, Ashley, House, Gail, Kamran, Asim, Manning, Kimberley, Nelder, Matthew, Noel, Lorilee, Norman, Alia, ODea, Jamie, Pinnell, Erin, Pochini, Craig, Putt, Dawne, Rahman, Arifur, Rickert, Lauren, Sathya, Jinka R, Teasdale, Breanne, Thoms, John, Whiteway, Chrystal, Whittle, Stacy, Cheung, Patrick CF, Chu, William, Chung, Hans T, Commisso, Angela, Danjoux, Cyril, Escueta, Vivette, Klotz, Laurence, Leung, Michael, Liu, Stanley, Loblaw, Douglas Andrew, Malek, Leila, Nam, Robert K, Szumacher, Ewa, Tseng, Eric Chia Lin, Vesprini, Danny, Abed, Jessy, Ang, Daniel, Bayley, Andrew J, Berlin, Alejandro, Bristow, Robert, Catton, Charles, Chan, Heidi, Chui, Amadeus, Chung, Peter, Degendorfer, Sarah, Gospodarowicz, Mary, Gregorcic, Emily, Gumapac, Nicole, Helou, Joelle, Hsien, John, Kong, Vickie, Lalani, Nafisha, Lao, Bernadeth, Lawson, Daeria, Merante, Pat, Milosevic, Michael, Mirmooji, Ramesh, Muraj, Zaynab, Peres, Sarin, Petroff, Avi, Petrovska, Aleksandra, Pineda, Sandra, Quintos, Judy, Raman, Srinivas, Ramotar, Sarah, Ruiz, Maria Jose Gaitan, Sabate, Kathryn, Shukla, Arundhati, Tharahan, Nanthini, Thevarajah, Vaishaali, Tiessen, Kyoko, Topalovich, Aleksandra, Torres, Cynthia, Tse, Karen, Tsuji, Debbie, Velec, Erin, Wallace, Kris, Warde, Padraig, Bisson, MarieEve, Dahmane, Rafika, Gagne, Vanessa, Harvey, Julie, Lebrun, Benoit, Marineau, Line, Montour, Julie, Samson, Julie, Sicard, MarieEve, Thibeault, Andreanne, Vincent, Francois, Vincent, LindaSuzanne, Blood, Paul A, Canavan, Joycelin, Clements, Mia AnnaMaria, Glick, Daniel, Holloway, Caroline, Holwerda, Eleanor, Joe, Howard, Lacey, Cathy, Lam, Jacqueline, Leong, Nelson, Lim, Jan, Lomas, Alia, Pai, Howard H, Priestley, Emilie, Shahid, Negin, Vallieres, Isabelle, Duncan, Graeme, Gleave, Martin E, Goldenberg, S Larry, Karunakaran, Subashini, Keyes, Mira, KimSing, Charmaine, McKenzie, Michael, Morris, William James, Nakashima, Lynne, Peacock, Michael, Pickles, Thomas A, Sibug, Sheena, So, Alan I, Tyldesley, Scott, Zhang, Tina Wanting, Ahmed, Shahida, Ammeter, Barb, Anderson, Leanne, Ann, Taehee, Bakija, Zeljka, Bashir, Bashir, Benjaminson, Patricia, Bergen, Leah, Cadiz, Lovely, Chahine, Jacqueline, Cherepak, Kathy, Chornopyski, Tracy, Chowdhury, Amitava D, Davies, Heather, Dawe, David, Drachenberg, Darrel E, DuMontier, Joelle, Eska, Tiffani, Francisco, Cristina, Gamez, Raquel, Garrett, Gina, Giovannini, Julia, Graham, Jeffrey, Guarino, Robyn, Hunter, William, Johnston, Laurel, Kitkowski, Caitlin, Klapp, Kathi, Koul, Rashmi, Kuzyk, Valerie, Last, Debbie, Li, KuanLin, Long, Heather, Majumdar, Arpita, Marek, Kathleen, McNish, Jennifer, Mills, Laurie, Morales, Maria, Nashed, Maged, 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9. Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
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Petsa, Maria, Redshaw, Catherine, Smith, Sarah-Ellen, Spoor, Willemijn, Thomas, Sister Viv, White, Holly, Worsley, Lucy, Bailey, Linda, Bennett, Molly, Corless, Rebecca, Duffy, Annie, Fellows, Kathryn, Gipson, Anna, Haydock, Helen, Knox, WF, Liptrott, Sarah, McCarth, Fiona, McCartin, Fiona, Mistry, Heena, Mthethwa, Thobekile, Partington, Lillian, Piper, Lindsay, Ramani, Vijay, Sahin, Sarah, Sangar, Vijay, Slevin, Kathryn, Tuck, Jonathan, Atkinson, Lorraine, Barnbrooke, Sarah, Barnes, Alison, Brownless, Caroline, Chadwick, David, Hardman, John, Harland, Keith, Long, Carol, McAuliffe, Sarah, McBride, Julia, McClurey, Sister Patricia, Mohan, Rita, Naylor, Lynne, Peedell, Clive, Robson, Paula, Shakespeare, Devadasan, Thompson, Emma, Van der Voet, Hans, Wilson, David, Barron, Chris, Frew, John, Lambert, Katy, McMenemin, Rhona, Pedley, Ian, Riseborough, Danielle, Roberts, Trevor, Stockley, Emma, Stoddart, Jonathan, Tate, Janine, Walker, Jayashree, Workman, Bridget, Barnett, Debra, Carter, Adam, Cox, Adam, Davey, Alison, Davies, Kirstin, Gilby, Lisa, Hodge, Simon, Kearney, S, Lavender, Helene, Marty, Janet, Nash, Maxine, Rahman, Syhed, Richards, Jayne, Simpson, Julie, Wall, Elaine, Webb, Paula, Wild, Karen, Wilson, Jim, Branagan, Jenny, Dell, Gillian, Foo, Maxine, Goyena, Ruby, Jones, Andrea, McBain, Hazel, McGrath, Katherine, O'Callaghan, Jane, Ramanathan, Dorai, Tee, Elizabeth, Thominson, Bronwen, Tighe (nee Bussey), Rachel, Beety, Jane, Birch, Richard, Bloomfield, Mark, Callam, Sara, Cooper, Adele, Darby, Helen, Healey, Gail, Heasley, Karen, Kapur, Guarav, London, Clare, Oosterom, Katrien, Ostrowski, Joe, Shobrook, Bridget, Turner, Sarah, Wade, Rob, Walker, Suzanne, Walton, Sharon, Websdale, Cheryl, White, Joanna, Alder, Leanne, Chivers, Rachael, Gooch, Carol, Howard, Lucy, Hutchinson, Camille, Jevons, Cody, Kumar, Daniel, Marley, Hazel, Mills, Jamie, Purves, Hanna, Sayers, Ian, Sundar, Santhanam, Szolin-Jones, Jacob, Walker, Georgina, Wood, Catherine, Cook, Wendy, Gill, Lisa, Johnson, Joanne, Johnstone, Dawn, Jones, Richard, Mistry, Leena, Scarratt, Lyndsay, Aiku, Abimbola, Ajzensztejn, Daniel, Al-Chamali, Hiba, Andrade, Gerard, Barber, Dave, Bekulart, Sylwia, Bhatnagar, Gagan, Boutflower, Jane, Brewster, Simon, Butterfield, Anne, Carroll, Weronika, Cole, David J, Coutts, Tim, Doyle, Kerrie, Durrant, Lisa, Green, Trish, Jampana, Raj, Jastrzebska, Patrycja, Kyffin, Phillippa, Langridge, Nicole, Lawrey, Sarah, Markus, Sarah, Marston, Kerrie, Mooney, Matthew, Mukkath, Sandra, Murphy, Ann, Owens, Rob, Ruane, Sarah, Sabbagh, Ahmad, Samkange, Grace, Sankighatta, Naveen, Skwarski, Michael, Stuart, Robert, Wellman, Sandie, Wilson, Jo, Cavanagh, Kerrie, Hollingdale, Abigail, Allen, Susan, Barter, Elisa, Gregory, Debbie, Ingle, Charlotte, Lawrence, Steph, Rooney, Paula-Joanne, Bishop, Emma, Brennan, Maria, Cogley, Lyn, Hammonds, John Christopher, McInerney, Paul, McLarty, Esther, Natale, Salvatore, Pascoe, Sarah, Purcell, Keith, Sells, Henry, Tyner, Sharah, yates, Victoria, Beamish, Neal, Blaney, Hilary, Clapp, Felicity, Clarke, Elizabeth, Coffin, Teresa, Davies, Joe, Downs, Nichola, Gillespie, Sally, Heckford, Louise, Iskender, Amanda, Orford, Sara, Pressdee, Sandy, Rix, Sophie, Wheelwright, Roger, Woodward, Elizabeth, Wright, Seonaid, Blight, Kathy, Dobson, Tracey, Hale, Jennifer, Harris-Burland, Angie, Khoury, Ghassan, Madhava, Kudingila, Meadows, Lorna, Nagar, Yoodhvir, Roca, Mila, Stacey, Wendy, Stephenson, Anna, Uherek, Maja, Virgo, Azarel, Watkinson, Catrin, Birtle, Alison, Chauhan, Zainab, Cornthwaite, Stephanie, Curtis, Sandra, Ellard, Rose, Fish, Nathan, Hefferon, Billy, Searle, Claire, Spickett, Helen, Walmsley, Catherine, Atkinson, Jane, Brown, Richard B, Cartwright, Debbie, Coomber, Kristy, Hunt, Allison, Kowalczyk-Williams, Wioletta, Lewis, Christina, Parr, Stephen, Purdon, Helen, Rogers, Paul, Vowell, Emma, Featherstone, Wendy, Hamilton, Joanna, Harrison, Alison, Hindle, Margaret, Hodson, Hayley, Isaew, Andrea, Knapp, Jeanette, Moss, Sarah, Gibbs, Stephanie, Gujral, Sandeep, Jannapureddy, Revanth, Kelkar, Anand, Martinou, Maria, Mills-Baldock, Tina, O'Brien, Neale, Subramaniam, Ramachandran, Tahir, Saad, Vandal, Mohammad Tanvir, Vu, Thi, Allen, Rachael, Betts, Chris, Bowmer, Amanda, Clarke, Noel, Cordwell, Amanda, Dharmaprasad, Soney, Duncan (nee Keatley), Claire, Farnworth, Christine, Farrell, Helen, George, Siny, Goulden, Kay, Harter, Leah, Kaushal, Malan, Kirk, Sister Sarah, Lau, Maurice, Lydon, Anne Marie, O'Flynn, Kieran, Platt, Danielle, Shackley, David, Stevenson, Garry, Taylor, Sister Melanie, Thompson, Chloe-Anne, Vinod, Cellins, Wadsworth, Oliver, Youd, Sister Jill, Attlee, Julie, Bhatnagar, Adityanarayan, Bunn, Sarah, Campbell, Allister, El-Saghir, Mohammed, Fennelly, Ruth, Guy, Peter, Mattocks, Lehentha, Mcintosh, Gregor, Murphy, Brenda, Reed, Catherine, Strong-Sheldrake, Sophia, Tedd, Gemma, Dent, Kathleen, Hood, Marion, Martin, Karen, Pearson, Sandra, Potoczna, Dorota, Spencer, Sue, Towse, Jo, Whotton, Nikita, Bowen, Katie, Clark, Su, Clarke, Rachael, Gibbins, Kate, Martin, Jackie, Smith, Suzanne, Spalton, Catherine, Tay, Jessica, Adams, Marion, Bates, Emma, Chennattukungu, Indukala, Clancy, Joanna, Cross, Vanessa, Hughes, Hayley, Jose, Sanal, Kurian-Downer, Sunita, Michael, Elena, Moore, Sister Helen, Nicholas, Karen, Pope, Suzanne, Potts, Sally, Prashant, Ravi, Singh, Harpreet, Smith, Sandra, Srihari, Narayanan, Weaver, Emma, Abbas, Ali, Barnes, Nicky, Dallas, Nicola, Jackson, Sister Ann, Kader, Nicole, Karim, Omer, Laniado, M, Litchfield, Jayne, Mahmood, Sana, O'Donnell, Helen, Robinson, Victoria, Sears, Alison, Sharif, Shahid, Sierra Pala, Ana, Sinclair, Julie-Ann, Smith, Sister Catherine, Ashcroft, Jan, Boardman, John, Bowes-Cavanagh, Jeanette, Brown, Rebecca, Chedham, Alison, Darch, Flora, Farrar, Michelle, Foot, Jayne, Goldsworthy, Simon, Graham, John, Gray, Emma, Green, Sara, Jelski, Joseph, Kalejaiye, Odunayo, Keni, Manjusha, Locke, Angela, Mahoney, Sue, McMeekin, Faith, Periasamy, Manivannan, Russell, Tamlyn, Ruszala, Elizabeth, Segaran, Surayne, Tighe, Mary, Wallbutton, Rebecca, Webster, Christine, Whitcher, Alison, Wiggins, Sarah, Wrigley, Martha, Zietz, Maria, Abab, Julie, Cumming, Kirsty, Galloway, Lucy, Ganabady, Malavika, Haskell, Annelise, Heath, Catherine, James, Naomi, Kennedy, Julie, McFarlane, Victoria, Morales-Azofra, Fabiola, Morton, Susan, Mundy, Carina, Noble, Mark, Paschalis, Alec, Patrick, Julie, Reader, Leanne, Taylor, Lisa, Wakefield, Shauna, Ahmed, Imtiaz, Bowman, Sue, Chan, Olivia, Cyriac, Abby, Davies, Tracey, Maitland, Katrina, Prejbisz, Jan, Reece, Sheila, Shires, Heather, Tsang, David, Anscombe, Eleanor, Brough, WA, Clitheroe, Pat, Cocks, Tracie, Connolly nee McKenna, Sarah, Corcoran, Sam, Coughlan, Tricia, Gilmour, Christina, Goodwin, Emma, Graham, Susan, Hatimy, Umi, Hodgkinson, Sheila, Kilmartin, John, Orrell, Lucy, Rotherham, Carol, Smallwood, Sarah, Taylor, Jill, Wiss, Elliott, Adab, Fawzi, Bhana, Rajanee, Dhinakaran, Kathirvelu, Evans, Marion, Myatt, Alison, Parkinson, Katrina, Peake, Angela, Sellars, Elizabeth, Smith, Rowena, Storer, Julie, Thomasson, Georgia, Vengalil, Salil, Walton, Jenny, Ward, Angela, Boam, Samantha, Burgoyne, Jamie-Rae, Chadwick, Eliot, Gill, Shafiq, Haigh, Steve, Hollis, Keri, Lim, Jun, McCabe, Alastair, Munson, Lyndsey, Nash, Dominic, Saunders, Daniel, Smith, Susan, Wade, Lynne, Evans, Elizabeth, Franklin, Alex, Harris (n. Marchant), Emily, Johnstone, Maria, Jones, Lewis, Lemon, Nicola, Phan, Mau-Don, Pudney, Delia, Spence, Rachael, Stretch, Alison, Tait, Ellen, Williams, Bethan, Belcher, Rebecca, De Silva-Minor, Shiroma, Dodge, Sister Jan, Grayland, Sarah, Jones, Ania, Khan, Omar, Owen, Tim, Palmer, Debbie, Parajes, Cerila, Pegler, Suzannah, Poole, Abbie, Sargent, Sister Tracey, Starling, Ellen, Taylor, Becky, Winter, Sister Helen, Zinyemba, Vivian, Allison, Michele, Blundell, Martyn, Brookman, Catherine, Buckley, Jon, Chamberlain, Shelley, Cuffe, Donna, Davies, Stacey, Fairfax, Claire, Greedus, Helen, Griffin, Hannah, Koehler, Ingrid, Lydon, Anna, Michels, Jorg, Pym, Julia, Roberts, Fiona, Thornton, Lorraine, Vandecandalaere, Elaine, Watts, Erica, Welsh, Linda, Anderson, Jim, Anderson, Juliette, Ball, Julie, Benton, Louise, Bowers, Richard, Chahal, Rohit, Dickinson, Peter, Fosker, Chris, Heeley, Janine, Kanaga-Sundaram, Subramanian, Littler, Stephen, Slack, Jonathan, Sundaram, Subramanian Kanaga, Taylor, Beverley, Weston, Philip, Chettle, Judith, Hartwell, Lyn, Johnson-Rollings, Ashley, Jones, Julia, Millage, Helen, O'Neill, Eilish, Walsh, Donna, Webb, Kerrie, Williams, Jo, Dymond, Harvey, Eleftheriadis, Symeon, Lloyd-Jones, Hugh, Wells, Tom, Bennett, Sarah, Dunn, Sharon, Fildes, Diane, Hassall, Alison, Herbert, Gaynor, Hughes, Kathryn, Innes, Helen, Kelly, Alison, Littler, John, Lomax, Laurie, Miller, Nikki, Nutman, Chris, Stott, Matthew, Syndikus, Isabel, Tolan, Shaun, Weston, Alison, Baker, Ivanna, Carter, Vanda, Chatfield, Jenny, Cooke, Peter, Grant, Anna, Homer, David, Kirk, Christine, Lomas, Claire, McCormick, Marian, Mohseeni, Arizoo, Pawaroo, Renita, Radford, Liz, Rogers, Jason, Samanci, Ali, Sharman, Emma, Spencer, Hazel, Spruce, Debbie, Worthington, Hannah, Bak, Dagmara, Cleary, Kristy, Davies, Sue, Gauntlett, Monica, Gupta, Kamalnayan, Holdsworth, Amanda, Ledger, Kate, Morrow, Hugh, Perry, Heather, Rimell, Patricia, Rosoman, Alison, Tyler, Jayne, White, Ann, Crowe (nee Hughes), Dawn, Flynn-Batham, Marian, Folkes, Linda, Funnell, Sarah, Gilbert, Jeanette, Gomez-Marcos, Raquel, Gonzalez, Celia, Hoskins, Chloe, Moore, Sally, Plataniotis, George, Rippin, Sarah, Smith, Matthew, Tsawayo, Tan, Turner, Nikki, Wakelen, Paula, Cserbane, Anita, Fernandez, Claire, Kurup, Rahul, Manyangadze, Sarah, McLain-Smith, Susan, Protheroe, Andrew, Trewsmith, Neil, Allison, Joanna, Barron, Claire, Beaumont, Erica, Beer, Nigel, Beesley, Kate, Donaldson, David, Duckett, Tracey, Fox, Shirley, Kotze, Michelle, Kumar, Shiyam, Macrory, Joanne, Perry, Jess, Pippard, Lucy, Porter, Tim, Rennie, Kerry, Sparrow, Geoffrey, Williams-Yesson, Barbara, Balderson, Jane, Bowling, Lorna, Brittain, Paul, Brookes, Claire, Campbell, Hilary, Campos, Monica, Conway, Rachel, Davies, Flor, Donnison, Michelle, Elliott, Mark, Evans, Richard, Fallah, Fereshteh, Fearnley, Mark, Giddings, Emma, Gollapothu, Srilakshmi, Harvey, Sally, Holbrook, Andy, Ingham, Jo, Jakeman, Christine, Joseph, Joji, Mole, Lisa, Musunuru, Hima Bindu, Pashley, Sarah, Saleem, Shamila, Stower, Michael, Strider, Paula, Taylor, Carol, Thackray, Louis, Todd, Joanna, Wightman, John, Wilson, Russ, Youngs, Nora, Byrne, Mary Marg, Deenihan, Emma, Durkan, Garret, Jennings, Marian, Mahoney, Catriona, Martin, Joseph, McInerney, Veronica, Raftery, Liz, Rogers, Eamonn, Spillane, Maria, Sullivan, Frank, Teh, Chiaw Woon, Wright, Ann, Harving, Niels, Hejlesen, Finn, Kempel, Mette Moe, Steffensen, Kirsten, Bentzen, Lise, Borre, Michael, Buus, Simon, Fode, Kirsten, Kaa Bach, Birgit, Lassen, Yasmin, Laursen, Vibeke, Lemng Kruse, Helle, Lucakova, Slavka, Nørmark Iversen, Helle, Brasso, Klaus, Christensen, Anne Juel, Gruschy, Lisa, Klovgaard, Karina, Lunau, Anne Sofie, Meidhal Petersen, Peter, Moller Christensen, Trine, Poder, Lone Lund, Ribers, Kristine, Stilling, Sine, Thim, Stine, Torin Lehmann, Anna, Vandborg, Maria, Christensen, Tine, Kokholm, Kathrine Friser, Lindberg, Henriette, Nybom, Kirstine, Rønnengart, Eva, Saxe, Charlotte, Baird, Noelle, Braun, Michael W, Cheung, Arthur, Fourt, Monica, Jackson, Cathy, Jepson, Debbie, Johnson, Arlissa, Karvat, Anand, Kwan, Winkle, McIndoe, Sue, Mitchell, Donna, Sandhu, Sandeep, Serpanchy, Rosanne, Wu, Helen, Beausoleil, Rachelle, Crawford, Melanie, DiMarco, Christine, Ding, Ian, Gladwish, Adam, MacIsaac, Patricia, MarshGray, Kimberley, Morton, Gerard, Murphy, Cara, Pascoe, Caitlin, Pokhrel, Sujata, Stevens, Christiaan, Yoon, Frederick, Yu, Jason, Dubey, Arbind, Sivananthan, Gokulan, Bahary, JeanPaul, Barkati, Maroie, Beauchemin, MarieClaude, Benth, Silvine, Carbonaro, Adriana, Delouya, Guila, ElSokhn, Nidale, Frazzi, Alexandra, Lambert, Carole, Lavertu, Sophie, Menard, Cynthia, Pan, Siew Siew, Rousseau, Pierre, Saad, Fred, Taussky, Daniel, Trudel, Diane, Amanie, John Oliver, Batz, Margaret, Borynec, Carol, Danielson, Brita, Garcia, Leni Santiago, Gramlich, Colin, Lang, Monika, Larson, Beverly, Mallett, Debbie, McCrudden, Sylvia, Murtha, Albert, Parker, Shelley, Parliament, Matthew B, Patel, Samir, Pearcey, Robert, Pervez, Nadeem, Rose, Jim, Shewchuk, Caroline, Smith, Carlie, Usmani, Nawaid, Williams, Candra, Yee, Don, AlRashdan, Abdulla, Avery, Alison, Beaton, Heather, Bond, Brittany, BrucePayne, Kim, Burbridge, Susan, Bursey, Kara, Carvery, Lane, Dill, Kendra, Dugas, Stevie, Harding, Claudia, Hodder, June, Hollenhorst, Helmut, Hubley, Lynn, Joseph, Paul K, Little, Erin, MacDonald, Angela, MacIsaac, Kathy, MacVicar, Jennifer, McCracken, Jillian, Moffatt, Emily, Nieforth, Joan, Patil, Nikhilesh, Rijt, Kelsey van der, Roberts, Victoria, Rose, Tina, Rutledge, Robert DH, Salyzyn, Camryn, Simpson, Robin, Sutherland, Donna, Walker, Heather, Wilke, Derek, Yeo, Tanya, Yunace, Lorrie, Zinck, Connie, Bier, Bianca, Bucci, Catherine, Corbett, Thomas B, Dayes, Ian S, Eady, Robin, Gudelis, Susan O, Hill, Elaine, Kinrade, Yvonne, Laughlin, Anne, Lukka, Himu, Makepeace, Barbara, Marshall, Lynn, Nielsen, Linda, Oliverio, Carmela, Patel, Malti Behn, Tsakirdis, Thedoros, Wong, Jason W T, Allen, Kirsten, Bachand, Francois, Carefoot, Layton, Cotts, Shannon, Creelman, Brianna, Crook, Juanita, GeorgeChayka, Danielle, Halperin, Ross, Hartt, Nancy, Hayes, Jill A, Kim, David, Kim, TuongVan, Kronstal, Flo, Lee, Bernard, Lew, Tanya, McClelland, Marie, Opitz, Debbie, Overend, Aldyn, Reed, Melanie, Watson, Michaella, Wilkie, Karen, Winn, Carol, Yanchuk, Janet, Bonner, Scott, Brander, Mike, Brundage, Michael, Carlson, Cindy, Edwards, Jackie, ElKerdawy, Hala, Harpell, Rhonda, Hartman, Carrie, Kalyvas, Maria, KirbyBello, Denise, Kumar, Vikaash, Leach, Deborah, MacVicar, Karen, Mahmud, Aamer, Maize, Christine, Moelker, Yvonne, Murano, Abby, Paul, Nancy, Ross, Ashley, RossSmith, Marleen, Shenfield, Carey, Spencer, Craig, Tennant, Virginia, Vermette, Tracy, Willing, Stephanie, Zaza, Khaled O, Zeltser, Fred, Gearing, Jennifer, Girolametto, Carla, Gopaul, Darindra, Hamilton, Ronald, Hendel, Debra, Janke, Susan, Knackstedt, Jochen, Kuk, Joda, Morrison, MaryBeth, Mumin, Anissa, Nemirov, Stephanie, Rachakonda, Ramana, Shantz, Brenda S, Siddiqui, Atif, Thallury, Sheeba, Ahmad, Belal, Bailey, Laura, Bauman, Glenn, Camara, Mary Jane, Corkery, Danylle, DSouza, David, DiLullo, Elenor, Eichenberger, Lois, Francis, Peggy, Grant, Susan, Gratton, Albert, Gurzanski, Christina, Hare, Jennifer A, Johnson, Craig, Kenny, Shannon, Lock, Michael I, Loughlin, Kate, Mardell, Stephen, Mayer, Heather, Rodrigues, George B, Sax, Lori, Sebborn, Kes, Sexton, Tracy, Venkatesan, Varagur M, tenHaaf, Darlene, Chatelain, AnneMarie, Fortin, Jacqueline, Houle, Stefanie, Khaouam, Nader, Lachance, Nicole, Laliberte, Benoit, Lemaire, Celine, Nguyen, David H A, Sylvestre, Alma, Vavassis, Peter, Yassa, Michael, Adnaan, Jamila, Briand, Wayne, Casey, Linda, Chipman, Penny, Corwin, Charlotte, Duclos, Marie, Faria, Sergio Luiz, Ghoul, Mokhtar, Joncas, MarieClaude, Koulouris, Zoe, Larocque, Stephanie, Lee, Brenda, Olha, Carolynna, Robert, MarieFrance, Sharma, Rajesh, Shenouda, George, Souhami, Luis, Albrecht, Virginia, Froese, Jane, Froude, Nancy, Howitt, Pamela, Iqbal, Fawaad, Kift, Shannon, Koll, Wayne, Li, Audrey, MacGregor, Barbara, Manganaro, Aileen, McKee, Dianne, Mendoza, Edeliza, Mui, Jimmy, Myrehaug, Sten, Singson, Angelina, Slessor, Janet, Somasiri, Ashane, Stevens, Nicole, Berghout, Koralee, Bourque, JeanMarc, Carkner, Amy, E, Choan, Eapen, Libni, Eze, Nancy, Fish, Matt, Haddad, Alain, Hicks, Kimberly, Iordanidi, Elina, Kanji, Femina, Kendal, Wayne S, MacMullin, Lisa, MacRae, Robert M, Malone, Shawn, Morgan, Scott, Nguyen, Julie, OBrien, Anna, Page, Nancy, Perry, Gad A, Reeves, MarieClaude, Roach, Joanne, Sanchez, Maria, Spearman, Mary, Spencer, Patti, Tikoo, Archana, Turriff, Lisa, Wright, Natalie, Bedoya, Luis Diaz de, Cossette, Danielle, Cusan, Leonello, Desrosiers, Isabelle, Dufour, Nathalie, Foster, William, Gomez, JoseLuis, Hathout, Lara, Lajoie, MarieAndree, Martin, AndreGuy, Pouliot, Sophie, Vigneault, Eric, Bouchard, Myriam, Bujold, Rachel, Carmel, Michel, Cote, Genevieve, Dion, Helene, Ebacher, Annie, Gauthier, Isabelle C, Ladouceur, Cynthia, Lamoureux, Alexandra, Larouche, Julie, Marquis, Tania, Nabid, Abdenour, Pearson, Diane, Sabbagh, Robert, TetreaultLaflamme, Audrey, Baker, Erin, Blackwood, Geoffrey, Galway, Denise, Greenland, Jonathan, Hannaford, Zeta, Hoskins, Ashley, House, Gail, Kamran, Asim, Manning, Kimberley, Nelder, Matthew, Noel, Lorilee, Norman, Alia, ODea, Jamie, Pinnell, Erin, Pochini, Craig, Putt, Dawne, Rahman, Arifur, Rickert, Lauren, Sathya, Jinka R, Teasdale, Breanne, Thoms, John, Whiteway, Chrystal, Whittle, Stacy, Cheung, Patrick CF, Chu, William, Chung, Hans T, Commisso, Angela, Danjoux, Cyril, Escueta, Vivette, Klotz, Laurence, Leung, Michael, Liu, Stanley, Loblaw, Douglas Andrew, Malek, Leila, Nam, Robert K, Szumacher, Ewa, Tseng, Eric Chia Lin, Vesprini, Danny, Abed, Jessy, Ang, Daniel, Bayley, Andrew J, Berlin, Alejandro, Bristow, Robert, Catton, Charles, Chan, Heidi, Chui, Amadeus, Chung, Peter, Degendorfer, Sarah, Gospodarowicz, Mary, Gregorcic, Emily, Gumapac, Nicole, Helou, Joelle, Hsien, John, Kong, Vickie, Lalani, Nafisha, Lao, Bernadeth, Lawson, Daeria, Merante, Pat, Milosevic, Michael, Mirmooji, Ramesh, Muraj, Zaynab, Peres, Sarin, Petroff, Avi, Petrovska, Aleksandra, Pineda, Sandra, Quintos, Judy, Raman, Srinivas, Ramotar, Sarah, Ruiz, Maria Jose Gaitan, Sabate, Kathryn, Shukla, Arundhati, Tharahan, Nanthini, Thevarajah, Vaishaali, Tiessen, Kyoko, Topalovich, Aleksandra, Torres, Cynthia, Tse, Karen, Tsuji, Debbie, Velec, Erin, Wallace, Kris, Warde, Padraig, Bisson, MarieEve, Dahmane, Rafika, Gagne, Vanessa, Harvey, Julie, Lebrun, Benoit, Marineau, Line, Montour, Julie, Samson, Julie, Sicard, MarieEve, Thibeault, Andreanne, Vincent, Francois, Vincent, LindaSuzanne, Blood, Paul A, Canavan, Joycelin, Clements, Mia AnnaMaria, Glick, Daniel, Holloway, Caroline, Holwerda, Eleanor, Joe, Howard, Lacey, Cathy, Lam, Jacqueline, Leong, Nelson, Lim, Jan, Lomas, Alia, Pai, Howard H, Priestley, Emilie, Shahid, Negin, Vallieres, Isabelle, Duncan, Graeme, Gleave, Martin E, Goldenberg, S Larry, Karunakaran, Subashini, Keyes, Mira, KimSing, Charmaine, McKenzie, Michael, Morris, William James, Nakashima, Lynne, Peacock, Michael, Pickles, Thomas A, Sibug, Sheena, So, Alan I, Tyldesley, Scott, Zhang, Tina Wanting, Ahmed, Shahida, Ammeter, Barb, Anderson, Leanne, Ann, Taehee, Bakija, Zeljka, Bashir, Bashir, Benjaminson, Patricia, Bergen, Leah, Cadiz, Lovely, Chahine, Jacqueline, Cherepak, Kathy, Chornopyski, Tracy, Chowdhury, Amitava D, Davies, Heather, Dawe, David, Drachenberg, Darrel E, DuMontier, Joelle, Eska, Tiffani, Francisco, Cristina, Gamez, Raquel, Garrett, Gina, Giovannini, Julia, Graham, Jeffrey, Guarino, Robyn, Hunter, William, Johnston, Laurel, Kitkowski, Caitlin, Klapp, Kathi, Koul, Rashmi, Kuzyk, Valerie, Last, Debbie, Li, KuanLin, Long, Heather, Majumdar, Arpita, Marek, Kathleen, McNish, Jennifer, Mills, Laurie, Morales, Maria, Nashed, Maged, Nichol, Rhonda, Ong, Aldrich Dixon, Ouelette, Ashley, Patel, DeepKumar, Pawl, Marilyn, Peak, Lisa, Priebe, Shauna, Quon, Harvey, Rizzuto, Stacey, Rudnicki, Rayleen, Santos, Priscilla, Sharma, Atul, Squires, Mandy, Trakalo, Kathy, Turner, Christy, Vaughn, Jamie, Walker, Lori, Watson, Melanie R, Wei, Joyce, Weir, JoAnn, Woloshyn, Rose, Wood, Allison, Zhang, Hanbo, Zwarych, Darlene, Parker, Chris C, Cook, Adrian D, Clarke, Noel W, Catton, Charles N, Cross, William R, Petersen, Peter M, Persad, Rajendra A, Pugh, Cheryl A, Bower, Lorna C, Bottomley, David M, Chung, Peter W M, Ford, Vicky, Goh, Chee L, Heath, Catherine M, James, Nicholas D, Kim-Sing, Charmaine, Kodavatiganti, Ravi, Malone, Shawn C, Morris, Stephen L, Ong, Aldrich D, Parulekar, Wendy R, Parmar, Mahesh K B, and Sydes, Matthew R
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- 2024
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10. Magnetic Resonance Imaging–Targeted Versus Systematic Prostate Biopsies: 2-year Follow-up of a Prospective Randomized Trial (PRECISE)
- Author
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Klotz, Laurence, Chin, Joseph, Black, Peter C., Finelli, Antonio, Anidjar, Maurice, Machado, Ashley, Levental, Mark, Ghai, Sangeet, Chang, Silvia D., Patel, Chirag, Kassam, Zahra, Loblaw, Andrew, Kebabdjian, Marlene, Pond, Greg, and Haider, Masoom A.
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- 2024
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11. Developing and validating a simple urethra surrogate model to facilitate dosimetric analysis to predict genitourinary toxicity
- Author
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Ratnakumaran, Ragu, Mohajer, Jonathan, Withey, Samuel J., H. Brand, Douglas, Lee, Ernest, Loblaw, Andrew, Tolan, Shaun, van As, Nicholas, and Tree, Alison C.
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- 2024
- Full Text
- View/download PDF
12. Randomized Trial of Concomitant Hypofractionated Intensity Modulated Radiation Therapy Boost Versus Conventionally Fractionated Intensity Modulated Radiation Therapy Boost for Localized High-Risk Prostate Cancer (pHART2-RCT)
- Author
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Glicksman, Rachel M., Loblaw, Andrew, Morton, Gerard, Vesprini, Danny, Szumacher, Ewa, Chung, Hans T., Chu, William, Liu, Stanley K., Tseng, Chia-Lin, Correa, Rohann, Deabreu, Andrea, Mamedov, Alexandre, Zhang, Liying, and Cheung, Patrick
- Published
- 2024
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- View/download PDF
13. Clinical implementation of magnetic resonance imaging simulation for radiation oncology planning: 5 year experience
- Author
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Moore-Palhares, Daniel, Ho, Ling, Lu, Lin, Chugh, Brige, Vesprini, Danny, Karam, Irene, Soliman, Hany, Symons, Sean, Leung, Eric, Loblaw, Andrew, Myrehaug, Sten, Stanisz, Greg, Sahgal, Arjun, and Czarnota, Gregory J.
- Published
- 2023
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14. Urethra contouring on computed tomography urethrogram versus magnetic resonance imaging for stereotactic body radiotherapy in prostate cancer
- Author
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Wee Loon Ong, M. Allan Hupman, Melanie Davidson, Mark Ruschin, Jay Detsky, Stanley Liu, Danny Vesprini, and Andrew Loblaw
- Subjects
Prostate SBRT ,Urethra contour ,Urethrogram ,MRI sequences ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Accurate urethra contouring is critical in prostate SBRT. We compared urethra contouring on CT-urethrogram and T2-weighted MRI. The dice similarity coefficient, Jaccard index, Hausdorff distance and mean distance to agreement were evaluated. All four metrics indicate better agreement and less variability in urethra contouring on CT-urethrogram, compared to T2-weighted MRI.
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- 2024
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15. Safety of Ultrahypofractionated Pelvic Nodal Irradiation in the Definitive Management of Prostate Cancer: Systematic Review and Meta-analysis
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Mohamad, Osama, Zamboglou, Constantinos, Zilli, Thomas, Murthy, Vedang, Aebersold, Daniel M., Loblaw, Andrew, Guckenberger, Matthias, and Shelan, Mohamed
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- 2024
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- View/download PDF
16. Stereotactic Body Radiation Therapy: A Radiosurgery Society Guide to the Treatment of Localized Prostate Cancer Illustrated by Challenging Cases
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Ma, Ting Martin, Ladbury, Colton, Tran, Maxwell, Keiper, Timothy D., Andraos, Therese, Gogineni, Emile, Mohideen, Najeeb, Siva, Shankar, Loblaw, Andrew, Tree, Alison C., Cheung, Patrick, Kresl, John, Collins, Sean, Cao, Minsong, and Kishan, Amar U.
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- 2024
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17. Genetic factors associated with prostate cancer conversion from active surveillance to treatment
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Jiang, Yu, Meyers, Travis J, Emeka, Adaeze A, Cooley, Lauren Folgosa, Cooper, Phillip R, Lancki, Nicola, Helenowski, Irene, Kachuri, Linda, Lin, Daniel W, Stanford, Janet L, Newcomb, Lisa F, Kolb, Suzanne, Finelli, Antonio, Fleshner, Neil E, Komisarenko, Maria, Eastham, James A, Ehdaie, Behfar, Benfante, Nicole, Logothetis, Christopher J, Gregg, Justin R, Perez, Cherie A, Garza, Sergio, Kim, Jeri, Marks, Leonard S, Delfin, Merdie, Barsa, Danielle, Vesprini, Danny, Klotz, Laurence H, Loblaw, Andrew, Mamedov, Alexandre, Goldenberg, S Larry, Higano, Celestia S, Spillane, Maria, Wu, Eugenia, Carter, H Ballentine, Pavlovich, Christian P, Mamawala, Mufaddal, Landis, Tricia, Carroll, Peter R, Chan, June M, Cooperberg, Matthew R, Cowan, Janet E, Morgan, Todd M, Siddiqui, Javed, Martin, Rabia, Klein, Eric A, Brittain, Karen, Gotwald, Paige, Barocas, Daniel A, Dallmer, Jeremiah R, Gordetsky, Jennifer B, Steele, Pam, Kundu, Shilajit D, Stockdale, Jazmine, Roobol, Monique J, Venderbos, Lionne DF, Sanda, Martin G, Arnold, Rebecca, Patil, Dattatraya, Evans, Christopher P, Dall’Era, Marc A, Vij, Anjali, Costello, Anthony J, Chow, Ken, Corcoran, Niall M, Rais-Bahrami, Soroush, Phares, Courtney, Scherr, Douglas S, Flynn, Thomas, Karnes, R Jeffrey, Koch, Michael, Dhondt, Courtney Rose, Nelson, Joel B, McBride, Dawn, Cookson, Michael S, Stratton, Kelly L, Farriester, Stephen, Hemken, Erin, Stadler, Walter M, Pera, Tuula, Banionyte, Deimante, Bianco, Fernando J, Lopez, Isabel H, Loeb, Stacy, Taneja, Samir S, Byrne, Nataliya, Amling, Christopher L, Martinez, Ann, Boileau, Luc, Gaylis, Franklin D, Petkewicz, Jacqueline, Kirwen, Nicholas, Helfand, Brian T, Xu, Jianfeng, Scholtens, Denise M, Catalona, William J, and Witte, John S
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Biological Sciences ,Genetics ,Clinical Research ,Prevention ,Human Genome ,Clinical Trials and Supportive Activities ,Urologic Diseases ,Aging ,Cancer ,Prostate Cancer ,genetics ,genome-wide association study ,prostate ,prostatic neoplasms - Abstract
Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active surveillance (AS) as their initial management strategy. While this may reduce the side effects of treatment for prostate cancer, many men on AS eventually convert to active treatment. PC is one of the most heritable cancers, and genetic factors that predispose to aggressive tumors may help distinguish men who are more likely to discontinue AS. To investigate this, we undertook a multi-institutional genome-wide association study (GWAS) of 5,222 PC patients and 1,139 other patients from replication cohorts, all of whom initially elected AS and were followed over time for the potential outcome of conversion from AS to active treatment. In the GWAS we detected 18 variants associated with conversion, 15 of which were not previously associated with PC risk. With a transcriptome-wide association study (TWAS), we found two genes associated with conversion (MAST3, p = 6.9×10-7 and GAB2, p = 2.0×10-6). Moreover, increasing values of a previously validated 269-variant genetic risk score (GRS) for PC was positively associated with conversion (e.g., comparing the highest to the two middle deciles gave a hazard ratio [HR] = 1.13; 95% Confidence Interval [CI]= 0.94-1.36); whereas, decreasing values of a 36-variant GRS for prostate-specific antigen (PSA) levels were positively associated with conversion (e.g., comparing the lowest to the two middle deciles gave a HR = 1.25; 95% CI, 1.04-1.50). These results suggest that germline genetics may help inform and individualize the decision of AS-or the intensity of monitoring on AS-versus treatment for the initial management of patients with low-risk PC.
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- 2022
18. To Boost or Not to Boost: Pooled Analyses From 2-Fraction SABR Trials for Localized Prostate Cancer
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Ong, Wee Loon, Cheung, Patrick, Chung, Hans, Chu, William, Detsky, Jay, Liu, Stanley, Morton, Gerard, Szumacher, Ewa, Tseng, Chia-Lin, Vesprini, Danny, Davidson, Melanie, Ravi, Ananth, McGuffin, Merrylee, Zhang, Liying, Mamedov, Alexandre, Deabreu, Andrea, Kulasingham-Poon, Meghan, and Loblaw, Andrew
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- 2023
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19. Dosimetric correlates of toxicities and quality of life following two-fraction stereotactic ablative radiotherapy (SABR) for prostate cancer
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Ong, Wee Loon, Davidson, Melanie, Cheung, Patrick, Chung, Hans, Chu, William, Detsky, Jay, Liu, Stanley, Morton, Gerard, Szumacher, Ewa, Tseng, Chia-Lin, Vesprini, Danny, Ravi, Ananth, McGuffin, Merrylee, Zhang, Liying, Mamedov, Alexandre, Deabreu, Andrea, Kulasingham-Poon, Meghan, and Loblaw, Andrew
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- 2023
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20. Clinical implementation of magnetic resonance imaging simulation for radiation oncology planning: 5 year experience
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Daniel Moore-Palhares, Ling Ho, Lin Lu, Brige Chugh, Danny Vesprini, Irene Karam, Hany Soliman, Sean Symons, Eric Leung, Andrew Loblaw, Sten Myrehaug, Greg Stanisz, Arjun Sahgal, and Gregory J. Czarnota
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Magnetic resonance ,Clinical workflow ,Patient setup ,Synthetic CT ,MRCAT ,Planning magnetic resonance ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose Integrating magnetic resonance (MR) into radiotherapy planning has several advantages. This report details the clinical implementation of an MR simulation (MR-planning) program for external beam radiotherapy (EBRT) in one of North America's largest radiotherapy programs. Methods and materials An MR radiotherapy planning program was developed and implemented at Sunnybrook Health Sciences Center in 2016 with two dedicated wide-bore MR platforms (1.5 and 3.0 Tesla). Planning MR was sequentially implemented every 3 months for separate treatment sites, including the central nervous system (CNS), gynecologic (GYN), head and neck (HN), genitourinary (GU), gastrointestinal (GI), breast, and brachial plexus. Essential protocols and processes were detailed in this report, including clinical workflow, optimized MR-image acquisition protocols, MR-adapted patient setup, strategies to overcome risks and challenges, and an MR-planning quality assurance program. This study retrospectively reviewed simulation site data for all MR-planning sessions performed for EBRT over the past 5 years. Results From July 2016 to December 2021, 8798 MR-planning sessions were carried out, which corresponds to 25% of all computer tomography (CT) simulations (CT-planning) performed during the same period at our institution. There was a progressive rise from 80 MR-planning sessions in 2016 to 1126 in 2017, 1492 in 2018, 1824 in 2019, 2040 in 2020, and 2236 in 2021. As a result, the relative number of planning MR/CT increased from 3% of all planning sessions in 2016 to 36% in 2021. The most common site of MR-planning was CNS (49%), HN (13%), GYN (12%), GU (12%), and others (8%). Conclusion Detailed clinical processes and protocols of our MR-planning program were presented, which have been improved over more than 5 years of robust experience. Strategies to overcome risks and challenges in the implementation process are highlighted. Our work provides details that can be used by institutions interested in implementing an MR-planning program.
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- 2023
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21. The use of virtual reality hypnosis for prostate cancer patients during transperineal biopsy/gold seed implantation: A needs assessment study
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Wong, Jane, McGuffin, Merrylee, Smith, Mackenzie, and Loblaw, Dr. Andrew
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- 2023
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22. Temporal Stability and Prognostic Biomarker Potential of the Prostate Cancer Urine miRNA Transcriptome
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Jeon, Jouhyun, Olkhov-Mitsel, Ekaterina, Xie, Honglei, Yao, Cindy Q, Zhao, Fang, Jahangiri, Sahar, Cuizon, Carmelle, Scarcello, Seville, Jeyapala, Renu, Watson, John D, Fraser, Michael, Ray, Jessica, Commisso, Kristina, Loblaw, Andrew, Fleshner, Neil E, Bristow, Robert G, Downes, Michelle, Vesprini, Danny, Liu, Stanley, Bapat, Bharati, and Boutros, Paul C
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Urologic Diseases ,Clinical Research ,Biotechnology ,Aging ,Prostate Cancer ,Prevention ,4.2 Evaluation of markers and technologies ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Good Health and Well Being ,Biomarkers ,Tumor ,Carcinogenesis ,Cohort Studies ,Humans ,Longitudinal Studies ,Male ,MicroRNAs ,Neoplasm Grading ,Prognosis ,Prostatic Neoplasms ,Reproducibility of Results ,Transcriptome ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
BackgroundThe development of noninvasive tests for the early detection of aggressive prostate tumors is a major unmet clinical need. miRNAs are promising noninvasive biomarkers: they play essential roles in tumorigenesis, are stable under diverse analytical conditions, and can be detected in body fluids.MethodsWe measured the longitudinal stability of 673 miRNAs by collecting serial urine samples from 10 patients with localized prostate cancer. We then measured temporally stable miRNAs in an independent training cohort (n = 99) and created a biomarker predictive of Gleason grade using machine-learning techniques. Finally, we validated this biomarker in an independent validation cohort (n = 40).ResultsWe found that each individual has a specific urine miRNA fingerprint. These fingerprints are temporally stable and associated with specific biological functions. We identified seven miRNAs that were stable over time within individual patients and integrated them with machine-learning techniques to create a novel biomarker for prostate cancer that overcomes interindividual variability. Our urine biomarker robustly identified high-risk patients and achieved similar accuracy as tissue-based prognostic markers (area under the receiver operating characteristic = 0.72, 95% confidence interval = 0.69 to 0.76 in the training cohort, and area under the receiver operating characteristic curve = 0.74, 95% confidence interval = 0.55 to 0.92 in the validation cohort).ConclusionsThese data highlight the importance of quantifying intra- and intertumoral heterogeneity in biomarker development. This noninvasive biomarker may usefully supplement invasive or expensive radiologic- and tissue-based assays.
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- 2020
23. Cost-effectiveness of docetaxel in high-volume hormone-sensitive metastatic prostate cancer
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Beca, Jaclyn, Majeed, Habeeb, Chan, Kelvin KW, Hotte, Sebastian J, Loblaw, Andrew, and Hoch, Jeffrey S
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Research ,Urologic Diseases ,Prostate Cancer ,Cancer ,Cost Effectiveness Research ,Comparative Effectiveness Research ,Clinical Trials and Supportive Activities ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Good Health and Well Being ,Urology & Nephrology ,Clinical sciences ,Oncology and carcinogenesis - Abstract
IntroductionThree pivotal trials have considered the addition of docetaxel (D) chemotherapy to conventional androgen-deprivation therapy (ADT) for the treatment of metastatic hormone- sensitive prostate cancer (HSPC). While an initial small trial was inconclusive, two larger trials demonstrated significant clinical benefit, including pronounced survival benefits (added 17 months) among patients with high-volume metastatic disease. Given the evolving clinical evidence, the cost-effectiveness of this approach warrants exploration.MethodsThe cost-effectiveness of six cycles of ADT+D compared to ADT alone to treat patients with high-volume metastatic HSPC was assessed from a Canadian public payer perspective. We included three health states: HSPC, metastatic castration-resistant prostate cancer (CRPC), and death. Survival data were obtained from the CHAARTED trial, which reported outcomes specifically for high-volume disease. We used Ontario costs data and utilities from the literature.ResultsIn the base case analysis, ADT+D cost an additional $25 757 and produced an extra 1.06 quality-adjusted life years (QALYs), resulting in an incremental cost-effectiveness ratio (ICER) of $24 226/QALY gained. Results from one-way sensitivity analysis across wide ranges of estimates and a range of scenarios, including an alternate model structure, produced ICERs below $35 000/QALY gained in all cases.ConclusionsThe use of D with ADT in high-volume metastatic HSPC appears to be an economically attractive treatment approach. The findings were consistent with other studies and robust in sensitivity analysis across a variety of scenarios.
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- 2019
24. Two-fraction stereotactic ablative radiotherapy with simultaneous boost to MRI-defined dominant intra-prostatic lesion – Results from the 2SMART phase 2 trial
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Ong, Wee Loon, Cheung, Patrick, Chung, Hans, Chu, William, Detsky, Jay, Liu, Stanley, Morton, Gerard, Szumacher, Ewa, Tseng, Chia-Lin, Vesprini, Danny, Davidson, Melanie, Ravi, Ananth, McGuffin, Merrylee, Zhang, Liying, Mamedov, Alexandre, Deabreu, Andrea, Kulasingham-Poon, Meghan, and Loblaw, Andrew
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- 2023
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25. Development and dissemination of structured hashtags for radiation oncology: Two-Year trends
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Baydoun, Atallah, Pereira, Ian J., Turner, Sandra, Siva, Shankar, Albert, Ashley A., Andrew Loblaw, D., Simcock, Richard A., Zaorsky, Nicholas G., and Katz, Matthew S.
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- 2023
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26. Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update
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Alexandria Bennett, Andrew Beck, Nicole Shaver, Roland Grad, Allana LeBlanc, Heather Limburg, Casey Gray, Ahmed Abou-Setta, Scott Klarenbach, Navindra Persaud, Guylène Thériault, Brett D. Thombs, Keith J. Todd, Neil Bell, Philipp Dahm, Andrew Loblaw, Lisa Del Giudice, Xiaomei Yao, Becky Skidmore, Elizabeth Rolland-Harris, Melissa Brouwers, Julian Little, and David Moher
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Systematic review ,Adults ,Guideline ,Primary care ,Prostate cancer ,Screening ,Medicine - Abstract
Abstract Purpose To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening for prostate cancer in adults aged 18 years and older in primary care. This protocol outlines the planned scope and methods for a series of systematic reviews. Methods Updates of two systematic reviews and a de novo review will be conducted to synthesize the evidence on the benefits and harms of screening for prostate cancer with a prostate-specific antigen (PSA) and/or digital rectal examination (DRE) (with or without additional information) and patient values and preferences. Outcomes for the benefits of screening include reduced prostate cancer mortality, all-cause mortality, and incidence of metastatic prostate cancer. Outcomes for the harms of screening include false-positive screening tests, overdiagnosis, complications due to biopsy, and complications of treatment including incontinence (urinary or bowel), and erectile dysfunction. The quality of life or functioning (overall and disease-specific) and psychological effects outcomes are considered as a possible benefit or harm. Outcomes for the values and preferences review include quantitative or qualitative information regarding the choice to screen or intention to undergo screening. For the reviews on benefits or harms, we will search for randomized controlled trials, quasi-randomized, and controlled studies in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials. For the review on values and preferences, we will search for experimental or observational studies in MEDLINE, Embase, and PsycInfo. For all reviews, we will also search websites of relevant organizations, gray literature, and reference lists of included studies. Title and abstract screening, full-text review, data extraction, and risk of bias assessments will be completed independently by pairs of reviewers with any disagreements resolved by consensus or by consulting with a third reviewer. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach will be used to assess the certainty of the evidence for each outcome. Discussion The series of systematic reviews will be used by the Canadian Task Force on Preventive Health Care to update their 2014 guideline on screening for prostate cancer in adults aged 18 years and older. Systematic review registration This review has been registered with PROSPERO (CRD42022314407) and is available on the Open Science Framework (osf.io/dm32k).
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- 2022
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27. Framework for Strengthening the Scholarship of Teaching and Learning in the Canadian College Sector
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De Courcy, Eileen, Loblaw, Tim, Paterson, Jessica, Southam, Theresa, and Wilson, Mary M.
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Following collaborative discussion and an initial literature review, a small group of college educators from three Canadian provinces, occupying roles at the micro, meso, and macro levels of their respective institutions, identified the need to develop a tool that considers institutional context in both determining the state of, and preparing for the advancement of, the state of the Scholarship of Teaching and Learning (SoTL). Further exploration into both the literature and our own experiences revealed that the state of SoTL within a particular institution seems to rely less on its categorization as a, for example, college, university, or technical institute, and more on the intricate web of factors that constitute the institution's context. While other researchers have put forth this call to consider institutional context to determine support for SoTL practices and processes, a detailed process or tool for doing so was not apparent. Adopting Bolman and Deal's (2008) framework for organizational structure, and combining this with data-gathering processes popularized by Smith's (2005) institutional ethnography, as well as a series of guiding questions, our tool represents an initial step in systematically representing SoTL-enabling and impeding artifacts commonly found in post-secondary institutions. Assuming SoTL leaders modify this tool based on their own entry points, a call is put forward to the Canadian post-secondary SoTL community to field-test the tool in order to facilitate reflection upon how a variety of factors encourage and impede SoTL advancement at our unique institutions, the interconnections between these factors and how we might use these to solve the pedagogical problems we face.
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- 2017
28. In Reply to Onal et al
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Ong, Wee Loon, primary, Zhang, Liying, additional, and Loblaw, Andrew, additional
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- 2024
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29. A Prospective Study of Magnetic Resonance Imaging-guided Focal Salvage High-dose-Rate Brachytherapy for Radiorecurrent Prostate Cancer: Updated Results of 30 Patients
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Corkum, Mark T., Morton, Gerard, Loblaw, D. Andrew, Tseng, Chia-Lin, Murgic, Jure, Ravi, Ananth, Davidson, Melanie T.M., Wronski, Matt, Haider, Masoom, and Chung, Hans T.
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- 2022
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30. Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial
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Lartigau, E, Patton, S, Thompson, A, Winkler, M, Wells, P, Lymberiou, T, Saunders, D, Vilarino-Varela, M, Vavassis, P, Tsakiridis, T, Carlson, R, Rodrigues, G, Tanguay, J, Iqbal, S, Morgan, S, Mihai, A, Li, A, Din, O, Panades, M, Wade, R, Rimmer, Y, Oommen, N, Tree, Alison C, Ostler, Peter, van der Voet, Hans, Chu, William, Loblaw, Andrew, Ford, Daniel, Tolan, Shaun, Jain, Suneil, Martin, Alexander, Staffurth, John, Armstrong, John, Camilleri, Philip, Kancherla, Kiran, Frew, John, Chan, Andrew, Dayes, Ian S, Duffton, Aileen, Brand, Douglas H, Henderson, Daniel, Morrison, Kirsty, Brown, Stephanie, Pugh, Julia, Burnett, Stephanie, Mahmud, Muneeb, Hinder, Victoria, Naismith, Olivia, Hall, Emma, and van As, Nicholas
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- 2022
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31. Absolute Percentage of Pattern 4 Disease as a Prognostic Measure for Intermediate-risk Prostate Cancer Treated with Stereotactic Body Radiotherapy
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Glicksman, R.M., Kishan, A.U., Quon, H., Shabsovich, D., Juarez, J., Jiang, T., Steinberg, M.L., Zhang, L., and Loblaw, A.
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- 2022
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32. Development and dissemination of structured hashtags for radiation oncology: Two-Year trends
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Atallah Baydoun, Ian J. Pereira, Sandra Turner, Shankar Siva, Ashley A. Albert, D. Andrew Loblaw, Richard A. Simcock, Nicholas G. Zaorsky, and Matthew S. Katz
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Social Media ,Twitter ,Radiation Oncology ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose: For radiation oncology, social media is a favored communication platform, but it uses non-structured hashtags, which limits communication. In this work, we created a set of structured hashtags with key opinion leaders in radiation oncology, and we report on their use after two years post-deployment. Materials/Methods: Hashtags were created, voted on, and refined by crowdsourcing 38 international experts, including physicians, physicists, patients, and organizations from North America, Europe, and Australia. The finalized hashtag set was shared with the radiation oncology community in September 2019. The number of tweets for each hashtag was quantified via Symplur through December 2021. For the top five tweeted hashtags, we captured the number of yearly tweets in the pre-deployment and post-deployment periods from 09/01/2019 to 08/31/2021. Results: The initial 2019 list contained 39 hashtags organized into nine categories. The top five hashtags by total number of tweets were: #Radonc, #PallOnc, #MedPhys, #SurvOnc, and #SuppOnc. Six hashtags had less than 10 total tweets and were eliminated. Post-deployment, there was an increase in the yearly tweets, with the following number of tweets by the second year post-deployment: #RadOnc (98,189 tweets), #MedPhys (15,858 tweets), and #SurvOnc (6,361 tweets). Two popular radiation oncology-related hashtags were added because of increased use: #DEIinRO (1,603 tweets by year 2) and #WomenWhoCurie (7,212 tweets by year 2). Over the two years, hashtags were used mostly by physicians (131,625 tweets, 34.8%). Conclusion: We created and tracked structured social media hashtags in radiation oncology. These hashtags disseminate information among a diverse oncologic community. To maintain relevance, regular updates are needed.
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- 2023
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33. Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update
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Bennett, Alexandria, Beck, Andrew, Shaver, Nicole, Grad, Roland, LeBlanc, Allana, Limburg, Heather, Gray, Casey, Abou-Setta, Ahmed, Klarenbach, Scott, Persaud, Navindra, Thériault, Guylène, Thombs, Brett D., Todd, Keith J., Bell, Neil, Dahm, Philipp, Loblaw, Andrew, Del Giudice, Lisa, Yao, Xiaomei, Skidmore, Becky, Rolland-Harris, Elizabeth, Brouwers, Melissa, Little, Julian, and Moher, David
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- 2022
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34. A political economy of TVET professionalisation : a case study of chefs at a Canadian polytechnic
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Loblaw, Timothy J.
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370.113 ,LC1001 Types of education, including humanistic, vocational, professional - Abstract
This thesis focuses on a political economy analysis of the relationship between the professional identity and professional development practices of instructors in the postsecondary educational sector of technical and vocational education and training (TVET). My study brings together the concept of the dual-professional identity of postsecondary TVET instructors, the practice of professional development in TVET, and a political economy approach. The research methods adapted for this postgraduate research study were from a qualitative perspective using a case study approach. The case study involved eight culinary instructors, the supervisor of the professional cooking programme, and the director of the hospitality and culinary careers school at a postsecondary polytechnic in Canada, selected using a non-probability sampling technique. My research explored what a political economy analysis would reveal about the relationship between the professional identity and the professional development practices of the culinary instructors/chefs. Throughout this thesis, I use the term, TVET professionalisation, to denote this relationship This case study contributes to knowledge and the TVET community in three intersecting ways. Its first contribution is in context - the research took place in the Canadian postsecondary TVET sector, for purposes of analysing the professional identity/professional development relationship in consideration of the historical, structural, and socio-cultural contexts of the institution. The case study's second contribution is in extending the literature of the political economy of skills. The findings demonstrate that analysing the professionalisation of the TVET culinary instructors, in consideration of the inter-relationship among the cultural, economic, political, and social contexts of the TVET system, is a suitable extension of the literature on the political economy of skills. From another perspective, the study also adds to the literature on the professionalisation of TVET instructors by considering professionalisation as an extension of the TVET workforce development imperative, which I note in this study as the discourse promoting employability and the axiomatic assumptions of TVET as 'training-for-growth' and 'skills-for work' (Anderson 2008). Thus, the study contributes to wider debates about the applicability of a political economy analysis beyond skill formation systems. Lastly, the case study contributes a conceptual framework for TVET professionalisation by interpreting the relationship between TVET professional identity and professional development through a political economy lens. The findings demonstrate that both the professional identity and the professional development practices of the culinary instructors in the case study were shaped by various contextual factors within the field of practice: namely, the instructor's personal history and sense of agency, the socio-cultural conventions of the culinary trade under investigation, the social and structural setting of the postsecondary TVET institution, and the workforce development imperative of TVET. The conceptual framework for TVET professionalisation also contributes another perspective toward the dual-professional identity of TVET instructors. Dual-professional identity formation within this study, and drawing upon the language of the research participants, refers to the process where the 'recipe' for the chefs' base identity was written in the professional trade of culinary arts. Once they joined the polytechnic, though, the chefs used the institution as 'stage' to 'go beyond the recipe' and elevate their identities by adding the ingredient of 'becoming an educator'. Based on an interpretation of the case study's findings, through a political economy lens of analysis, I suggest that the 'skilled-educator' identity of the culinary instructors is bound by the structural and socio-economic contexts of the postsecondary polytechnic, whereas the 'skilled-tradesperson' identity of the culinary instructors reflects the historical and socio-cultural contexts of the instructors' lived experience as chefs. Further, I posit that each instructor's perception of meaningful professional development reflects the individual's personal sense of agency; what constitutes both a personal and shared sense of legitimacy concerning the value of professional development; and, an allegiance to one of the dual-professional identities over the other.
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- 2018
35. Gantry-Based 5-Fraction Elective Nodal Irradiation in Unfavorable-Risk Prostate Cancer: Outcomes From 2 Prospective Studies Comparing SABR Boost With MR Dose-Painted HDR Brachytherapy Boost
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Musunuru, Hima Bindu, Cheung, Patrick, Vesprini, Danny, Liu, Stanley K., Chu, William, Chung, Hans T., Morton, Gerard, Deabreu, Andrea, Davidson, Melanie, Ravi, Ananth, Helou, Joelle, Ho, Ling, Zhang, Liying, and Loblaw, Andrew
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- 2022
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36. Four-year Prostate-specific Antigen Response Rate as a Predictive Measure in Intermediate-risk Prostate Cancer Treated With Ablative Therapies: The SPRAT Analysis
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Glicksman, R.M., Kishan, A.U., Katz, A.J., Mantz, C.A., Collins, S.P., Fuller, D.B., Steinberg, M.L., Shabsovich, D., Zhang, L., and Loblaw, A.
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- 2022
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37. Defining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI
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Liu, Wei, Fakir, Hatim, Randhawa, Gurpreet, Alfano, Ryan, Corkum, Mark, Kassam, Zahra, Rachinsky, Irina, Chung, Hans T., Chung, Peter, Loblaw, Andrew, Morton, Gerard, Sexton, Tracy, Kapoor, Anil, Ward, Aaron, Zukotynski, Katherine, Emmett, Louise, and Bauman, Glenn
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- 2022
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38. Defining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI
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Wei Liu, Hatim Fakir, Gurpreet Randhawa, Ryan Alfano, Mark Corkum, Zahra Kassam, Irina Rachinsky, Hans T. Chung, Peter Chung, Andrew Loblaw, Gerard Morton, Tracy Sexton, Anil Kapoor, Aaron Ward, Katherine Zukotynski, Louise Emmett, and Glenn Bauman
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Prostate cancer ,PSMA PET/CT ,MRI ,Radio-recurrence ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose: Our purpose was to evaluate intra-prostatic cancer volumes for salvage radiotherapy in men with recurrent prostate cancer confined to the prostate post-primary radiotherapy using mpMRI and 18F-DCFPyL PET/CT (PET). Methods: Men with biochemical failure post-primary radiotherapy were enrolled in a multi-centre trial investigating mpMRI and PET. All men with isolated intra-prostatic recurrence are included in this secondary analysis. The intra-prostatic gross tumour volume (GTV) was manually delineated on mpMRI and was also delineated on PET using three methods: 1. manually, 2. using a 30% threshold of maximum intra-prostatic standard uptake value (SUVmax), and 3. using a 67% threshold of this SUVmax. Clinical target volumes (CTV) including expansions on each GTV were generated. Conformity indices were performed between the mpMRI CTV and each PET CTV. Correlation with biopsy and clinical outcomes were performed. Results: Of the 36 men included, 30 (83%) had disease in two quadrants or less using the combination of mpMRI and PET. Mean target volume (union of CTV on mpMRI and CTV manually delineated on PET) was 12.2 cc (49% of prostate gland volume). 12/36 (33%) men had a biopsy. Per-patient sensitivity was 91% for mpMRI and 82% for PET. Conclusions: mpMRI and PET provide complementary information for delineation of intra-prostatic recurrent disease. Union of CTV on mpMRI and PET is often less than 50% of the prostate, suggesting this imaging could help define a target for focal salvage therapy.
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- 2022
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39. Delivery of Virtual Care in Oncology: Province-Wide Interprofessional Consensus Statements Using a Modified Delphi Process
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Matthew C. Cheung, Bryan B. Franco, Nicholas Meti, Alia Thawer, Houman Tahmasebi, Adithya Shankar, Andrew Loblaw, Frances C. Wright, Colleen Fox, Naomi Peek, Vivian Sim, and Simron Singh
- Subjects
consensus ,virtual care ,teleoncology ,telemedicine ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Virtual cancer care (i.e., teleoncology) was rapidly adopted during the COVID-19 pandemic to meet the needs of patients with cancer. However, there is a paucity of guidance for clinicians regarding virtual cancer care. We sought to develop consensus-based statements to guide the optimal provision of virtual care for clinicians caring for patients with cancer, using a modified Delphi consensus process with a 29-member panel consisting of an interprofessional group of clinicians caring for patients with cancer and patient representatives. The consensus process consisted of two rounds and one synchronous final consensus meeting. At the end of the modified Delphi process, 62 of 62 statements achieved consensus. Fifty-seven statements reached consensus in the first round of the process. Concerns regarding the ability to convey difficult news virtually and maintaining similar standards as in-person care without disproportionate strain on clinicians and patients were addressed in the consensus process. We achieved interprofessional consensus on virtual cancer care practices. Further research examining the impact of virtual cancer care on person-centred and clinical outcomes are needed to inform practices during the COVID-19 pandemic and beyond.
- Published
- 2021
- Full Text
- View/download PDF
40. Multiparametric Magnetic Resonance Imaging in the Diagnosis of Clinically Significant Prostate Cancer: an Updated Systematic Review
- Author
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Haider, M.A., Brown, J., Yao, X., Chin, J., Perlis, N., Schieda, N., and Loblaw, A.
- Published
- 2021
- Full Text
- View/download PDF
41. Brachytherapy for high grade prostate cancer induces distinct changes in circulating CD4 and CD8 T cells – Implications for systemic control
- Author
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Wang, H., primary, Mendez, L., additional, Morton, G., additional, Loblaw, A., additional, Chung, H.T., additional, Cheung, P., additional, Mesci, A., additional, Escueta, V., additional, Petchiny, T.N., additional, Huang, X., additional, White, S.D., additional, Downes, M., additional, Vesprini, D., additional, and Liu, S.K., additional
- Published
- 2024
- Full Text
- View/download PDF
42. Moving Unfavorable Small-Bowel Anatomy Away From the Prostate to Optimize Radiation Therapy Plans With the GU-Lok
- Author
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Glicksman, Rachel M., Davidson, Melanie, Wong, Andrew, Binda, Shawn, Reinhart, Rebecca, and Loblaw, Andrew
- Published
- 2021
- Full Text
- View/download PDF
43. Multipurpose ultrasound-based prostate phantom for use in interstitial brachytherapy
- Author
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Shaaer, Amani, Alrashidi, Saad, Chung, Hans, Loblaw, Andrew, Morton, Gerard, Paudel, Moti, Tseng, Chia-Lin, and Ravi, Ananth
- Published
- 2021
- Full Text
- View/download PDF
44. Stereotactic Body Radiotherapy for High-Risk Localized Carcinoma of the Prostate (SHARP) Consortium: Analysis of 344 Prospectively Treated Patients
- Author
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van Dams, Ritchell, Jiang, Naomi Y., Fuller, Donald B., Loblaw, Andrew, Jiang, Tommy, Katz, Alan J., Collins, Sean P., Aghdam, Nima, Suy, Simeng, Stephans, Kevin L., Yuan, Ye, Nickols, Nicholas G., Murthy, Vedang, Telkhade, Tejshri P., Kupelian, Patrick A., Steinberg, Michael L., Romero, Tahmineh, and Kishan, Amar U.
- Published
- 2021
- Full Text
- View/download PDF
45. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer
- Author
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Ghiam, Alireza Fotouhi, Taeb, Samira, Huang, Xiaoyong, Huang, Vincent, Ray, Jessica, Scarcello, Seville, Hoey, Christianne, Jahangiri, Sahar, Fokas, Emmanouil, Loblaw, Andrew, Bristow, Robert G, Vesprini, Danny, Boutros, Paul, and Liu, Stanley K
- Subjects
Cancer ,Urologic Diseases ,Genetics ,Prostate Cancer ,Aging ,Aetiology ,2.1 Biological and endogenous factors ,Cell Cycle ,Cell Line ,Tumor ,Cell Proliferation ,Gene Expression Profiling ,Gene Expression Regulation ,Neoplastic ,Humans ,Male ,Neoplasm Grading ,Prostatic Neoplasms ,RNA ,Long Noncoding ,Radiation Tolerance ,Survival Analysis ,Up-Regulation ,lncRNA ,UCA1 ,irradiation resistant ,prostate cancer ,biomarker ,Oncology and Carcinogenesis - Abstract
Radioresistance remains a significant obstacle in the treatment of Prostate Cancer (PCa). To simulate the clinical scenario of irradiation resistance (IRR), we created DU145-IRR PCa cell lines by treatment with 2 Gy daily IR for 59 fractions. DU145-IRR cells acquired an aggressive phenotype as evidenced by increased clonogenic survival, tumorigenic potential and invasiveness. We performed transcriptome profiling to discover dysregulated genes in DU145-IRR cells and identified the long non-coding RNA (lncRNA), Urothelial carcinoma-associated 1 (UCA1). We first investigated the role of UCA1 in radiation response and found that UCA1 abundance was significantly higher in DU145-IRR cells compared to control cells. UCA1 siRNA-knockdown reversed the aggressive phenotype and significantly increased sensitivity to IR. UCA1 depletion inhibited growth, induced cell cycle arrest at the G2/M transition and decreased activation of the pro-survival Akt pathway. We then studied the clinical significance of UCA1 expression in two independent cohorts of PCa patients: MSKCC (130 patients) and CPC-GENE (209 patients). UCA1 over-expression was associated with decreased 5-year disease-free survival in MSKCC patients (HR = 2.9; p = 0.007) and a trend toward lower biochemical recurrence-free survival in CPC-GENE patients (HR = 2.7; p = 0.05). We showed for the first time that UCA1 depletion induces radiosensitivity, decreases proliferative capacity and disrupts cell cycle progression, which may occur through altered Akt signaling and induced cell cycle arrest at the G2/M transition. Our results indicate that UCA1 might have prognostic value in PCa and be a potential therapeutic target.
- Published
- 2017
46. Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer.
- Author
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Fotouhi Ghiam, Alireza, Taeb, Samira, Huang, Xiaoyong, Huang, Vincent, Ray, Jessica, Scarcello, Seville, Hoey, Christianne, Jahangiri, Sahar, Fokas, Emmanouil, Loblaw, Andrew, Bristow, Robert G, Vesprini, Danny, Boutros, Paul, and Liu, Stanley K
- Subjects
Cell Line ,Tumor ,Humans ,Prostatic Neoplasms ,Survival Analysis ,Gene Expression Profiling ,Cell Cycle ,Cell Proliferation ,Gene Expression Regulation ,Neoplastic ,Up-Regulation ,Radiation Tolerance ,Male ,Neoplasm Grading ,RNA ,Long Noncoding ,UCA1 ,biomarker ,irradiation resistant ,lncRNA ,prostate cancer ,Cell Line ,Tumor ,Gene Expression Regulation ,Neoplastic ,RNA ,Long Noncoding ,Oncology and Carcinogenesis - Abstract
Radioresistance remains a significant obstacle in the treatment of Prostate Cancer (PCa). To simulate the clinical scenario of irradiation resistance (IRR), we created DU145-IRR PCa cell lines by treatment with 2 Gy daily IR for 59 fractions. DU145-IRR cells acquired an aggressive phenotype as evidenced by increased clonogenic survival, tumorigenic potential and invasiveness. We performed transcriptome profiling to discover dysregulated genes in DU145-IRR cells and identified the long non-coding RNA (lncRNA), Urothelial carcinoma-associated 1 (UCA1). We first investigated the role of UCA1 in radiation response and found that UCA1 abundance was significantly higher in DU145-IRR cells compared to control cells. UCA1 siRNA-knockdown reversed the aggressive phenotype and significantly increased sensitivity to IR. UCA1 depletion inhibited growth, induced cell cycle arrest at the G2/M transition and decreased activation of the pro-survival Akt pathway. We then studied the clinical significance of UCA1 expression in two independent cohorts of PCa patients: MSKCC (130 patients) and CPC-GENE (209 patients). UCA1 over-expression was associated with decreased 5-year disease-free survival in MSKCC patients (HR = 2.9; p = 0.007) and a trend toward lower biochemical recurrence-free survival in CPC-GENE patients (HR = 2.7; p = 0.05). We showed for the first time that UCA1 depletion induces radiosensitivity, decreases proliferative capacity and disrupts cell cycle progression, which may occur through altered Akt signaling and induced cell cycle arrest at the G2/M transition. Our results indicate that UCA1 might have prognostic value in PCa and be a potential therapeutic target.
- Published
- 2017
47. Stereotactic Body Radiotherapy: Hitting Harder, Faster, and Smarter in High-Risk Prostate Cancer
- Author
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Rohann J. M. Correa and Andrew Loblaw
- Subjects
high-risk prostate cancer ,elective nodal irradiation (ENI) ,PSMA-PET ,dose escalation ,stereotactic body radiotherapy (SBRT) ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Stereotactic body radiotherapy (SBRT) is a technologically sophisticated form of radiotherapy that holds significant potential to effectively treat high-risk prostate cancer (HRPC). Prostate SBRT has been the subject of intense investigation in the context of low- and intermediate-risk disease, but less so for HRPC. However, emerging data are demonstrating its potential to safely and efficiently delivery curative doses of radiotherapy, both to the prostate and elective lymph nodes. SBRT theoretically hits harder through radiobiological dose escalation facilitated by ultra-hypofractionation (UHRT), faster with only five treatment fractions, and smarter by using targeted, focal dose escalation to maximally ablate the dominant intraprostatic lesion (while maximally protecting normal tissues). To achieve this, advanced imaging modalities like magnetic resonance imaging and prostate specific membrane antigen positron emmission tomography (PSMA-PET) are leveraged in combination with cutting-edge radiotherapy planning and delivery technology. In this focused narrative review, we discuss key evidence and upcoming clinical trials evaluating SBRT for HRPC with a focus on dose escalation, elective nodal irradiation, and focal boost.
- Published
- 2022
- Full Text
- View/download PDF
48. Effects of a Long Term Dietary Portfolio and of Sequential Removal of Food Components From the Diet
- Author
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Canada Research Chairs Endowment of the Federal Government of Canada, Natural Sciences and Engineering Research Council, Canada, Loblaw Companies Limited, Almond Board of California, Unilever R&D, and David Jenkins, Principle Investigator
- Published
- 2018
49. Portfolio 5 - Multicentre Dietary Advice on Serum Lipids in Hyperlipidemia
- Author
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Canadian Institutes of Health Research (CIHR), Loblaw Companies Limited, Solae, LLC, Unilever R&D, and David Jenkins, Principle Investigator
- Published
- 2018
50. Outcomes of Urinary Tract Infection Management by Pharmacists (RxOUTMAP)
- Author
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Horizon Health Network, New Brunswick Pharmacists' Association, Loblaw Companies Ltd., Pharmasave Drugs (Atlantic) Ltd., Alberta Pharmacists Association, The Jean Coutu Group (PJC) Inc., and Ross T. Tsuyuki, Professor of Medicine (Cardiology) and Director, EPICORE Centre, University of Alberta
- Published
- 2018
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