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252 results on '"Lobina, Carla"'

10. Analgesic effects of saikosaponin A in a rat model of chronic inflammatory pain.

Author

Lobina, Carla, Lee, Jung Hwan, Pel, Pisey, Chin, Young-Won, Kwon, Hak Cheol, and Colombo, Giancarlo

Subjects
CHRONIC pain, ANIMAL disease models, SALICYLIC acid, BUPLEURUM, HYPERALGESIA, EXPERIMENTAL arthritis
Abstract

Saikosaponin A (SSA) is the main active ingredient of roots of the East Asian medicinal plant, Bupleurum falcatum L. The present study was aimed at delving into the analgesic properties of SSA in a model of chronic inflammatory pain. To this end, rats were initially treated intraplantarly with complete Freund's adjuvant for induction of hyperalgesia. Twenty-four hours later, rats were acutely treated with SSA (0, 1 and 2 mg/kg, i.p.) and exposed to the Von Frey monofilament test or Randall–Selitto paw pressure test for assessment of mechanical hyperalgesia. Treatment with 2 mg/kg SSA had analgesic effects: the nocifensive reaction (paw withdrawal) occurred later and required application of the nociceptive stimulus at a stronger pressure. The analgesic effects of SSA were of magnitude comparable to that of the effects exerted by the reference compound, acetyl salicylic acid (100 mg/kg, i.p.). The well-described anti-inflammatory properties of SSA likely underlie its analgesic effects. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Development of tolerance upon repeated administration with the GABAB receptor positive allosteric modulator, COR659, on alcohol drinking in rodents

Author

Lorrai, Irene, primary, Shankula, Chase, additional, Marquez Gaytan, Jorge, additional, Maccioni, Riccardo, additional, Lobina, Carla, additional, Maccioni, Paola, additional, Brizzi, Antonella, additional, Mugnaini, Claudia, additional, Gessa, Gian Luigi, additional, Sanna, Pietro Paolo, additional, Corelli, Federico, additional, and Colombo, Giancarlo, additional

Published
2022
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15. Development of tolerance upon repeated administration with the GABAB receptor positive allosteric modulator, COR659, on alcohol drinking in rodents.

Author

Lorrai, Irene, Shankula, Chase, Marquez Gaytan, Jorge, Maccioni, Riccardo, Lobina, Carla, Maccioni, Paola, Brizzi, Antonella, Mugnaini, Claudia, Gessa, Gian Luigi, Sanna, Pietro Paolo, Corelli, Federico, and Colombo, Giancarlo

Subjects
ALCOHOL drinking, LABORATORY rats, RODENTS, LABORATORY mice, ALCOHOL
Abstract

Background: Recent work has demonstrated that acute administration of the novel positive allosteric modulator of the GABAB receptor, COR659, reduces several alcohol-related behaviors in rodents. Objective: To assess whether COR659 continues to lessen alcohol intake after repeated administration, a fundamental feature of drugs with therapeutic potential. Methods: Male C57BL/6J mice (n = 40) were exposed to daily 2-hour drinking sessions (20% (v/v) alcohol) under the 1-bottle "drinking in the dark" protocol and male Sardinian alcohol-preferring rats (n = 40) were exposed to daily 1-hour drinking sessions under the 2-bottle "alcohol (10%, v/v) vs water" choice regimen. COR659 (0, 10, 20, and 40 mg/kg in the mouse experiment; 0, 5, 10, and 20 mg/kg in the rat experiment) was administered intraperitoneally before 7 consecutive drinking sessions. Results: Alcohol intake in vehicle-treated mice and rats averaged 2.5–3.0 and 1.5–1.6 g/kg/session, respectively, indicative of high basal levels. In both experiments, treatment with COR659 resulted in an initial, dose-related suppression of alcohol intake (up to 70–80% compared to vehicle treatment; P <.0005 and P <.0001 in mouse and rat experiments, respectively). The magnitude of the reducing effect of COR659 on alcohol drinking diminished progressively, until vanishing over the subsequent 2–4 drinking sessions. Conclusion: COR659 effectively reduced alcohol intake in two different rodent models of excessive alcohol drinking. However, tolerance to the anti-alcohol effects of COR659 developed rapidly. If theoretically transposed to humans, these data would represent a possible limitation to the clinical use of COR659. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse

Author

Lobina, Carla, primary, Maccioni, Paola, additional, Lorrai, Irene, additional, Zaru, Alessandro, additional, Collu, Maria, additional, Carai, Mauro A.M., additional, Brizzi, Antonella, additional, Mugnaini, Claudia, additional, Gessa, Gian Luigi, additional, Corelli, Federico, additional, and Colombo, Giancarlo, additional

Published
2021
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22. Comparison of the Effect of the GABAB Receptor Agonist, Baclofen, and the Positive Allosteric Modulator of the GABAB Receptor, GS39783, on Alcohol Self-Administration in 3 Different Lines of Alcohol-Preferring Rats

Author

Maccioni, Paola, Zaru, Alessandro, Loi, Barbara, Lobina, Carla, Carai, Mauro A. M., Gessa, Gian Luigi, Capra, Alessandro, Mugnaini, Claudia, Pasquini, Serena, Corelli, Federico, Hyytiä, Petri, Lumeng, Lawrence, and Colombo, Giancarlo

Published
2012
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28. Analgesic properties of a food grade lecithin delivery system of Zingiber officinale and Acmella oleracea standardized extracts in rats.

Author

Lobina, Carla, Sau, Roberta, Fara, Federica, Maccioni, Paola, Carai, Mauro A. M., and Colombo, Giancarlo

Subjects
GINGER, RATS, LECITHIN, EXPERIMENTAL arthritis
Abstract

This study investigated whether (i) the 5:1 combination of standardized extracts of Zingiber officinale and Acmella oleracea is endowed with analgesic effects and (ii) the phospholipid-based formulation of Zingiber officinale and Acmella oleracea extracts (ZAP) potentiated the analgesic effects of the plain extract combination (PEC). To this end, rats were exposed to acute pain (Tail Flick test) and chronic, inflammatory pain [Von Frey monofilament test and Randall–Selitto paw pressure test in rats treated intraplantarily with complete Freund's adjuvant (CFA)]. The plain combination of per se ineffective doses of the two extracts produced analgesic effects in healthy rats. ZAP was more potent and effective than the corresponding doses of PEC. ZAP also produced analgesic effects in CFA-treated rats. Studies are now warranted to assess whether the analgesic properties of ZAP may generalize to humans. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Administration of the metabotropic glutamate receptor subtype 5 allosteric modulator GET 73 with alcohol: A translational study in rats and humans

Author

Haass-Koffler, Carolina L, primary, Goodyear, Kimberly, additional, Loche, Antonella, additional, Long, Victoria M, additional, Lobina, Carla, additional, Tran, Harrison H, additional, Cacciaglia, Roberto, additional, Swift, Robert M, additional, Colombo, Giancarlo, additional, and Leggio, Lorenzo, additional

Published
2018
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49. Comparison of the effect of the GABAB receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats

Author

Maccioni, Paola, Zaru, Alessandro, Loi, Barbara, Lobina, Carla, Carai, Mauro A.M., Gessa, Gian Luigi, Capra, Alessandro, Mugnaini, Claudia, Pasquini, Serena, Corelli, Federico, Hyytiä, Petri, Lumeng, Lawrence, and Colombo, Giancarlo

Subjects
Male, Baclofen, Reinforcement Schedule, Alcohol Drinking, Ethanol, Self Administration, Cyclopentanes, Article, Rats, Pyrimidines, Allosteric Regulation, Species Specificity, GABA-B Receptor Agonists, Animals, GABA Modulators
Abstract

Administration of the GABA(B) receptor agonist, baclofen, and positive allosteric modulator, GS39783, has been repeatedly reported to suppress multiple alcohol-related behaviors, including operant oral alcohol self-administration, in rats. This study was designed to compare the effect of baclofen and GS39783 on alcohol self-administration in 3 lines of selectively bred, alcohol-preferring rats: Indiana alcohol-preferring (P), Sardinian alcohol-preferring (sP), and Alko Alcohol (AA).Rats of each line were initially trained to respond on a lever, on a fixed ratio (FR) 4 (FR4) schedule of reinforcement, to orally self-administer alcohol (15%, v/v) in daily 30-minute sessions. Once responding reached stable levels, rats were exposed to a sequence of experiments testing baclofen (0, 1, 1.7, and 3 mg/kg; i.p.) and GS39783 (0, 25, 50, and 100 mg/kg; i.g.) on FR4 and progressive ratio (PR) schedules of reinforcement. Finally, to assess the specificity of baclofen and GS39783 action, rats were slightly food-deprived and trained to lever-respond for food pellets.The rank of order of the reinforcing and motivational properties of alcohol was PsPAA rats. Under both FR and PR schedules of reinforcement, the rank of order of potency and efficacy of baclofen and GS39783 in suppressing alcohol self-administration was PsPAA rats. Only the highest dose of baclofen reduced lever-responding for food pellets; this effect was common to all 3 rat lines. Conversely, no dose of GS39783 altered lever-responding for food in any rat line.These results suggest that: (i) the strength of the reinforcing and motivational properties of alcohol differ among P, sP, and AA rats; (ii) the reinforcing and motivational properties of alcohol in P, sP, and AA rats are differentially sensitive to treatment with baclofen and GS39783; (iii) the heterogeneity in sensitivity to baclofen and GS39783 of alcohol self-administration in P, sP, and AA rats may resemble the differential effectiveness of pharmacotherapies among the different typologies of human alcoholics; and (iv) the GABA(B) receptor is part of the neural substrate mediating the reinforcing and motivational properties of alcohol.

Published
2012

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