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Introduction: Recently, there have been some reports about the antifungal and antimicrobial effects of Satureja bachtiarica. This study aimed to determine the effects of Clotrimazole-Satureja bachtiarica vaginal cream and compare with those of Clotrimazole vaginal cream in patients with vaginal candidiasis. Methods: This randomized double-blind clinical trial was carried out on 80 women of childbearing age that referred to Hajar Hospital in Shahrekord, Iran. The cases in the first group received Clotrimazole-Satureja bachtiarica vaginal cream and in the second group, the patients received Clotrimazole vaginal cream. Clinical and laboratory signs and symptoms were recorded at baseline and after the treatment by questionnaires and forms. Both groups were treated for 7 days. The data were analyzed in SPSS software (version 21) using paired t-test, Chi-square test, repeated measures, and independent t-test. P-value less than 0.05 was considered statistically significant. Results: The results of the present study showed that the amount of vaginal discharge (P=0.0001), dysuria (P=0.014), and vaginal itching (P=0.048) in the Clotrimazole-Satureja group were significantly less than those of the Clotrimazole group. There was no significant differences in the erythema of the vulva and vagina (P=0.108), as well as dyspareunia (P=0.118), between the Clotrimazole-Satureja group and the Clotrimazole group. No significant correlation was observed between the recarturrent and the studied groups (P=0.130). Conclusion: The results of this study showed that the therapeutic effects of Clotrimazole-Satureja bachtiarica vaginal cream were not only similar to those of Clotrimazole vaginal cream but also more effective at improving the symptoms of vaginal candidiasis. Therefore, the use of this cream is suggested for the treatment of vaginal candidiasis infection.

Introduction: Menopause for women is a global phenomenon. Flushing is of the symptoms which women experience during menopause. The treatment which is now used for flushing is hormone replacement that has many side-effects. One of the alternatives for hormone therapy is the use of plants from the family of phytoestrogens, such as evening primrose. This study was performed with aim to evaluate the effect of evening primrose on hot flashes during menopause. Methods: This triple-blind clinical trial study was performed on 100 postmenopausal women referred to the health centers of Dastena in 2015. The subjects were assigned to two groups of placebo (n=50) evening primrose (n=50). The women participating in this study used Perle's a warm evening primrose plant or placebo twice a day for one month. Kuperman questionnaire was used to assess symptoms of menopause. Data was analyzed by SPSS software (version 11) and Chi-square and t-test. P

Background: Increased concentrations of tumor necrosis factor alpha (TNF-α) in blood and amniotic fluid are observed in women with preterm delivery (PTD) and TNF-α mutations at −308 position are associated with higher expression of this gene. Therefore, we compared the frequency of G308A transition in the promoter region of TNF-α gene of women and neonates delivered preterm with the normal subjects. Methods: This cross-sectional study was performed on 135 mothers who were referred for delivery. According to the gestational age, mothers and their neonates were allocated to the case (preterm, 64 subjects) and control (term, 71 subjects) groups. Using the polymerase chain reaction, restrictive fragment length polymorphism (RFLP), genotyping was performed on both maternal peripheral blood and cord blood samples to determine single nucleotide polymorphism in the promoter region of TNF-α gene at -308. Results: Two mothers in the case group, one mother in the control group and one neonate in the case group had genotyping assays (GA) mutation. All other subjects had normal GG genotype. Frequency of GA mutation was not significantly different between two groups (P = 0.47). Conclusions: There is no significant association between PTD and either maternal or fetal TNF-α −308 polymorphism and frequency ofGAmutation is not significantly increased in mothers and neonates delivered preterm. It means that the presence of this mutation by itself does not modify the overall risk of PTD. Investigations on the combination of various polymorphisms indifferent genes are recommended to achieve more accurate results.

Introduction: Cesarean delivery is the most common and costly gynaecologic surgery, with an increase in rate all over the world. Aim: The present study aimed to estimate the effect of uterine cavity cleansing with normal saline solution during cesarean delivery on the rate of infection, fever, bleeding and postoperative gastrointestinal complications. Materials and Methods: This study was a clinical trial carried out on 90 pregnant women who underwent elective cesarean delivery. The subjects were randomly assigned into two groups of 45 individuals, including rinsing in 500ml of normal saline solution during cesarean delivery (intervention group) and nonrinsed (control group). Postoperative complications include bleeding, fever, wound infection were examined. The data related to postoperative gastrointestinal complications and endometritis at the second day and one and six weeks after surgery were collected and data were analysed through SPSS 17. Results: There was no significant difference between two groups regarding febrile morbidity two days after the surgery. The rate of one-week postoperative febrile morbidity was higher in the control group but not statistically significant. The difference in the incidence of fever, wound infection and endometritis on the second day and on the first week was not statistically significant but the incidence of endometritis on the sixth week after surgery was significant in the intervention group than control group and was less in the intervention group, the wound infection at sixth week after surgery was fewer in the intervention group but not statistically significant. There was no significant difference between two groups in terms of gastrointestinal complications. Conclusion: Uterine cavity cleansing with normal saline solution during cesarean delivery may decrease postoperative complication, although the reduction is not statistically significant.

Introduction: Counting fetal movements may lead to timely assess fetal health and prevent the adverse effects of pregnancy. Aim: The aim of this study was to determine the effect of fetal movement counting on pregnancy outcomes. Materials and Methods: In a randomized controlled trial, 208 women with singleton pregnancy were randomly divided into two groups of fetal movement counting and control. Pregnancy outcomes were compared between the two groups. Data were analysed with SPSS and p

Background and Aim: Lawsonia inermis is a medicinal plant with abortive properties. There has been no scientific study to evaluate the teratogenicity of this plant. This study was performed to determine the antioxidant activity and the possible side effect of L. inermis hydroalcoholic extract on development of congenital abnormalities in BALB/c mice. Materials and Methods: In this experimental study, 120 female mature BALB/c mice were assigned to four groups and after mating and confirming the vaginal plug, the animals in the first group (G1) were kept with no intervention, and the second (G2), third (G3) and fourth (G4) groups were intraperitoneally (ip) injected with respectively saline (0.3 ml), and 10 and 100 mg/ kg of L. inermis extract (for 7 days). On the 19th day, caesarean section was performed on the mice and embryos were examined for abnormalities. Their height and weight were measured. Data were analysed by ANOVA and post-hoc least significant difference tests. Results: There were significant differences between G3 and G4, and G1 (p