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In a cohort of subjects with asymptomatic carotid atherosclerosis (ACA), we have evaluated the neutrophil and lymphocyte count and their ratio (NLR), the gelatinases (MMP-2 and MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2). At baseline, no difference was observed between ACA subjects and subject control group regarding neutrophil and lymphocyte count while was evident in ACA subjects a significant increase in MMP-2, MMP-9 and TIMP-2 associated to a significant decrease in TIMP-1. Dividing the ACA according to the number of cardiovascular risk factors (CRFs) we have observed an increase in lymphocyte count in the subgroup with 3–5 CRFs. Evaluating the leukocyte subtypes according to all the surrogate markers of insulin resistance has been noted, in the subgroups that exceed the medians of these markers, a significant increase in neutrophil and lymphocyte count without any variation of the NLR. Effecting the same evaluation for the MMP/TIMP pattern we observed, instead, that the same subgroups tend to show a decrease in MMP-2 and an increase in MMP-9. No difference instead for TIMP-1 and TIMP-2. The abnormality of the MMP/TIMP pattern, bearing in mind the cardiometabolic clustering present in this cohort of ACA subjects, would induce to use drugs able not only to cure the cardiometabolic risk factors but also to influence the MMP/TIMP profile.

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Few discoveries in the history of medicine had a greater impact than William Harvey’s discovery of the circulation of blood, and few intellectual milieus of the early modern period had as decisive a part in the rise of ‘modern’ medicine and the shaping of the western scientific mentality in general than the philosophical and scientific movement of ‘Venetian Aristotelianism’, which grew up around the University of Padua, where Harvey himself had studied. In this chapter, I aim to explore some aspects of the intellectual movement of ‘Venetian Aristotelianism’ as well as the debate that ensued upon the discovery of the circulation of blood. My focus, however, is not on any of the major protagonists, but rather on a quite marginal figure in this debate, namely Hieronymus Franzosi.

Il termine "disfunzione endoteliale" identifica una condizione patologica caratterizzata da ridotta vasodilatazione e da attività procoagulante e pro-infiammatoria, correlata ad una ridotta biodisponibilità di ossido nitrico (NO), ad un eccesso ossidativo e ad un'aumentata azione dell'endotelian 1 (ET-1).

Aim: To explore red blood cells (RBC) and leukocyte rheology, that may be relevant in the pathophysiology of diabetes mellitus. Methods and Results: Significant alterations have been observed in RBC behaviour using several filtration techniques, but the exploration of RBC deformability by laser diffractometry did not show any abnormality. We have also employed microrheological methods based on fluorescence spectroscopy: membrane microviscosity was evaluated in ghosts, while in intact RBC we explored the membrane polarity gradient using fluorescent fatty acids, the phospholipid and protein lateral mobility using respectively pyrene and pyrene-3-maleimide. Alterations emerged only using the latter methods. We also investigated the filterability of polymorphonuclear leukocytes (PMN), their membrane fluidity and cytosolic Ca2+ concentration, both at baseline and after in vitro activation. At baseline no difference was evident in PMN filtration parameters or in cytosolic calcium content between normals and diabetics; a difference was noted in membrane fluidity. In normals, activation only induced a decrease in filterability, whereas in diabetics of both types we also observed an increase in cytosolic Ca2+ content and, only in type 1 diabetics, a decrease in membrane fluidity. Moreover, PMNs showed an altered integrin pattern in diabetes. Conclusions: The functional impairment observed in blood cells of diabetic subjects can play a role in the development of vascular complications.

Aim: The sport of soccer is characterized by neuromuscular performance resulting in short bursts interspersed by brief recovery periods over an extended period of time. Several studies suggest that the cardiac autonomic nervous system (ANS) assessed by heart rate variability (HRV) may provide useful information regarding the functional adaptations to training stimulus. Although HRV has often been associated with aerobic power and cardiovascular fitness, the influence of sympathovagal balance on neuromuscular performance in young athletes is not well assessed. The aim of this study was to assess the influence of the autonomic system on the performance of repeated sprints, involving predominantly muscular power and anaerobic metabolism, in young soccer players. Method: Twelve young soccer players, selected for the Sicilian Regional Representative of the Italian Football Federation, mean age 15 years, were recruited. Resting HRV was measured and indices of power spectral analysis (ratio LF/HF) were calculated to evaluate the sympathovagal balance. To assess the state of physical fitness of subjects, VO2max was determined by maximal graded treadmill test. Finally, the athletes performed 10 maximal all-out 6-sec cycling sprints (RS), interspersed with 30-sec of passive recovery, to measure the peak power (PP) represented by the highest value recorded during a single sprint, and the average of the values of maximum power (AP) recorded during all sprints. Results: On the basis of their VO2max (56.22 ± 3.93 ml/Kg/min), all subjects showed good levels of physical fitness. HRV index (LF/HF = 1.31 ± 0.74) showed an inverse correlation with PP (14.05 ± 0.89 W/Kg; r = -0.709, P = 0.01), and with AP (12.82 ± 0.88 W/Kg; r = -0.606, P = 0.04). Conclusion: Our study shows that a low ratio LF/HF, which reflects a parasympathetic predominance in the ANS balance, is associated with a better anaerobic contribution to performance resulting in higher values of PP and AP during brief repeated maximal cycling sprints. The assessment of resting HRV before exercise may be useful for performance monitoring of young soccer players.

Objectives. Myocardial infarction is a relatively unusual phenomenon in young subjects. The aim if this work is to characterize the risk profile and factors influencing outcomes of these patients since it makes possible to manage prevention interventions. Patients and Methods. We examined cardiovascular risk factors, clinical presentation, angiographic picture and outcome of a group of young patients hospitalized for a myocardial infarction. We enrolled 121 young patients consecutively admitted to our hospital for a myocardial infarction and examined them not only at the initial stage, but also after 3 months and one year; finally a long-term telephonic follow up was performed, when possible. Results. We found some peculiarity making these patients quite different from the older ones who develop a myocardial infarction: cigarettes smoking, family history of ischemic heart disease and hyperlipidemia were the most frequent cardiovascular risk factors, while diabetes and hypertension were less represented; moreover coronary angiography showed more frequently a less extensive coronary atherosclerosis. Patients who developed a cardiovascular event at follow-up presented a significantly higher prevalence of hypertension and obesity and a significantly lower frequency of healthy coronary arteries and of previous revascularization. Conclusions. Myocardial infarction in young adults presents several peculiarities, represented not only by the risk profile, but also by the angiographic picture and the prognosis. Considering the long life expectancy of the involved population, the essential role of preventive interventions should be strongly underlined.

Our goal was to evaluate some plasma markers of platelet and polymorphonuclear leukocyte (PMN) activation in a group of young adults with acute myocardial infarction (AMI) at the initial stage and after three months. We enrolled 49 AMI subjects aged

Understanding past sea-level change plays an important role in determining the underlying causes, and also allows the extrapolation of past sea levels to locations and epochs for which there are no instrumental data. A compilation of global sea-level estimates based on deep-sea oxygen isotope ratios at millennial-scale resolution or higher was published since ‘70. These global sea level curves do not take in account isostasy and tectonics. Observed sea level change can be reconstructed from dated fossils, coral reef terraces, speleothems, emerged and forming terraces on coastal areas, archaeological and other markers well connected with sea level. Because of the lack of coral reefs in the Mediterranean sea, results on late Quaternary sea level changes have been difficult to obtain in comparison with typical sites such as Barbados, the Huon Peninsula, Tahiti, Florida and others. On the contrary the very low tidal range of Mediterranean seas offers a good opportunity to produce precise observations and considerations on climatic change. As regard the last highstand (Holocene), sea level change is the sum of eustatic, glacio-hydro-isostatic, and tectonic factors. The first is time-dependent while the latter two also vary with location. This means that at the same time slices the relative sea level (the sum of 3 different movements) should be different in different coastlines. Coastal settlements and maritime installations built in antiquity provide important insights into sea-level changes during past millennia. Reconstructions of historical sea-level change using archaeological coastal sites are particularly effective in the Mediterranean (continua...)

Pallidotomy has recently been reconfirmed as effective for otherwise intractable symptoms of Parkinson's disease. Nonetheless almost every aspect of its performance requires choices which are not fully established and may vary between centers. These include: 1) patient selection; 2) choice of imaging modality, 3) choice of anatomic landmarks for targeting the lesion, 4) choice of method for physiologic confirmation of location, 5) choice of lesion size and shape. We present two cases of pallidotomy procedures in Parkinsonian patients that in our knowledge are the first reported in Italy. Our experience and a careful review of the literature led to the following choices: 1) selection of Parkinsonian patients with dominant L-Dopa induced dyskinesia, akinetic and rigidity symptoms, 2) use of CT due to the distortion effects of MRI, 3) use of standard (Laitinen) coordinates combined with an image fusion method using MRI, 4) use of stimulation to gauge distance to internal capsule and optic tract, 5) production of vertical lesion covering internal segment of pallidum. At a 1-year follow-up the results include a 45% drop in UPDRS (Unified Parkinson's Disease Rating Scale) motor score and almost complete resolution of contralateral dopa induced dyskinesias in both patients.