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293 results on '"Löwik, Clemens W G M"'

1. MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer

Author

Metman, Madelon J. H., Jonker, Pascal K. C., Sondorp, Luc H. J., van Hemel, Bettien M., Sywak, Mark S., Gill, Anthony J., Jansen, Liesbeth, van Diest, Paul J., van Ginhoven, Tessa M., Löwik, Clemens W. G. M., Nguyen, Anh H., Robinson, Dominic J., van Dam, Gooitzen M., Links, Thera P., Coppes, Rob P., Fehrmann, Rudolf S. N., and Kruijff, Schelto

Published
2024
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2. Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection

Author

Jonker, Pascal K. C., Metman, Madelon J. H., Sondorp, Luc H. J., Sywak, Mark S., Gill, Anthony J., Jansen, Liesbeth, Links, Thera P., van Diest, Paul J., van Ginhoven, Tessa M., Löwik, Clemens W. G. M., Nguyen, Anh H., Coppes, Robert P., Robinson, Dominic J., van Dam, Gooitzen M., van Hemel, Bettien M., Fehrmann, Rudolf S. N., and Kruijff, Schelto

Published
2022
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3. MET-receptor targeted fluorescent imaging and spectroscopy to detect multifocal papillary thyroid cancer

Author

Metman, Madelon J. H., primary, Jonker, Pascal K. C., additional, Sondorp, Luc H. J., additional, van Hemel, Bettien M., additional, Sywak, Mark S., additional, Gill, Anthony J., additional, Jansen, Liesbeth, additional, van Diest, Paul J., additional, van Ginhoven, Tessa M., additional, Löwik, Clemens W. G. M., additional, Nguyen, Anh H., additional, Robinson, Dominic J., additional, van Dam, Gooitzen M., additional, Links, Thera P., additional, Coppes, Rob P., additional, Fehrmann, Rudolf S. N., additional, and Kruijff, Schelto, additional

Published
2023
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5. Indocyanine-enhanced mouse model of bleomycin-induced lung fibrosis with hallmarks of progressive emphysema

Author

Grandi, Andrea, primary, Ferrini, Erica, additional, Mecozzi, Laura, additional, Ciccimarra, Roberta, additional, Zoboli, Matteo, additional, Leo, Ludovica, additional, Khalajzeyqami, Zahra, additional, Kleinjan, Alex, additional, Löwik, Clemens W. G. M., additional, Donofrio, Gaetano, additional, Villetti, Gino, additional, and Stellari, Franco Fabio, additional

Published
2023
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7. Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection

Author

MS CGO, Pathologie, Cancer, Jonker, Pascal K C, Metman, Madelon J H, Sondorp, Luc H J, Sywak, Mark S, Gill, Anthony J, Jansen, Liesbeth, Links, Thera P, van Diest, Paul J, van Ginhoven, Tessa M, Löwik, Clemens W G M, Nguyen, Anh H, Coppes, Robert P, Robinson, Dominic J, van Dam, Gooitzen M, van Hemel, Bettien M, Fehrmann, Rudolf S N, Kruijff, Schelto, MS CGO, Pathologie, Cancer, Jonker, Pascal K C, Metman, Madelon J H, Sondorp, Luc H J, Sywak, Mark S, Gill, Anthony J, Jansen, Liesbeth, Links, Thera P, van Diest, Paul J, van Ginhoven, Tessa M, Löwik, Clemens W G M, Nguyen, Anh H, Coppes, Robert P, Robinson, Dominic J, van Dam, Gooitzen M, van Hemel, Bettien M, Fehrmann, Rudolf S N, and Kruijff, Schelto

Published
2022

13. Real-time fluorescence imaging in intraoperative decision making for cancer surgery

Author

Lauwerends, Lorraine J, primary, van Driel, Pieter B A A, additional, Baatenburg de Jong, Robert J, additional, Hardillo, José A U, additional, Koljenovic, Senada, additional, Puppels, Gerwin, additional, Mezzanotte, Laura, additional, Löwik, Clemens W G M, additional, Rosenthal, Eben L, additional, Vahrmeijer, Alexander L, additional, and Keereweer, Stijn, additional

Published
2021
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15. Toward Optimization of Imaging System and Lymphatic Tracer for Near-Infrared Fluorescent Sentinel Lymph Node Mapping in Breast Cancer

Author

Mieog, J. Sven D., Troyan, Susan L., Hutteman, Merlijn, Donohoe, Kevin J., van der Vorst, Joost R., Stockdale, Alan, Liefers, Gerrit-Jan, Choi, Hak Soo, Gibbs-Strauss, Summer L., Putter, Hein, Gioux, Sylvain, Kuppen, Peter J. K., Ashitate, Yoshitomo, Löwik, Clemens W. G. M., Smit, Vincent T. H. B. M., Oketokoun, Rafiou, Ngo, Long H., van de Velde, Cornelis J. H., Frangioni, John V., and Vahrmeijer, Alexander L.

Published
2011
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18. Optical Image-guided Surgery—Where Do We Stand?

Author

Keereweer, Stijn, Kerrebijn, Jeroen D. F., van Driel, Pieter B. A. A., Xie, Bangwen, Kaijzel, Eric L., Snoeks, Thomas J. A., Que, Ivo, Hutteman, Merlijn, van der Vorst, Joost R., Mieog, J. Sven D., Vahrmeijer, Alexander L., van de Velde, Cornelis J. H., Baatenburg de Jong, Robert J., and Löwik, Clemens W. G. M.

Published
2011
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23. Imaging Bioluminescent Exogenous Stem Cells in the Intact Guinea Pig Cochlea

Author

Schomann, Timo, Mezzanotte, Laura, de Groot, John C M J, Löwik, Clemens W G M, Frijns, Johan H M, Huisman, Margriet A, Schomann, Timo, Mezzanotte, Laura, de Groot, John C M J, Löwik, Clemens W G M, Frijns, Johan H M, and Huisman, Margriet A

Abstract

Stem-cell-based therapy may be used to replace damaged or lost neurons in the cochlear nerve of patients suffering from severe-to-profound sensorineural hearing loss. In order to achieve functional recovery in future clinical trials, knowledge about survival of grafted cells and their differentiation into functional neurons is a prerequisite. This calls for non-invasive in vivo visualization of cells and long-term monitoring of their survival and fate after cochlear transplantation. We have investigated if molecular optical imaging enables visualization of exogenous cells in the intact cochlea of guinea pig cadaver heads. Transduced (stem) cells, stably co-expressing fluorescent (copGFP) and bioluminescent (Luc2) reporter molecules, were injected into the internal auditory meatus or directly into the cochlea through the round window. After injection of the cells into the internal auditory meatus, a bright bioluminescent signal was observed in the cavum conchae of the auricle, indicating that light generated by Luc2 is passing through the tympanic membrane and the external auditory meatus. Similar results were obtained after injection of the cells through the round window membrane, either directly into the scala tympani or in Rosenthal's canal within the modiolus of the basal cochlear turn. Imaging of the auditory bulla demonstrated that the bioluminescent signal passes through the tympanic membrane and crevices in the bony wall of the bulla. After opening the auditory bulla, the bioluminescent signal was emanating from the round window. This is the first study demonstrating that bioluminescence imaging enables visualization of luciferase-expressing cells injected into the intact guinea pig cochlea. Anat Rec, 303:427-440, 2020. © 2019 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.

Published
2020

27. “In Vivo” Molecular Imaging

Author

Kaijzel, Eric L., primary, Snoeks, Thomas J. A., additional, Que, Ivo, additional, Baiker, Martin, additional, Kok, Peter, additional, Lelieveldt, Boudewijn P., additional, and Löwik, Clemens W. G. M., additional

Published
2010
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35. Necroptotic Cell Death in Liver Transplantation and Underlying Diseases:Mechanisms and Clinical Perspective

Author

Shi, Shaojun, Verstegen, Monique M A, Mezzanotte, Laura, de Jonge, Jeroen, Löwik, Clemens W G M, van der Laan, Luc J W, Shi, Shaojun, Verstegen, Monique M A, Mezzanotte, Laura, de Jonge, Jeroen, Löwik, Clemens W G M, and van der Laan, Luc J W

Abstract

Cell death is a natural process for the turnover of aged cells, but it can also arise as a result of pathological conditions. Cell death is recognized as a key feature in both acute and chronic hepatobiliary diseases caused by drug, alcohol, and fat uptake; by viral infection; or after surgical intervention. In the case of chronic disease, cell death can lead to (chronic) secondary inflammation, cirrhosis, and the progression to liver cancer. In liver transplantation, graft preservation and ischemia/reperfusion injury are associated with acute cell death. In both cases, so-called programmed cell death modalities are involved. Several distinct types of programmed cell death have been described of which apoptosis and necroptosis are the most well known. Parenchymal liver cells, including hepatocytes and cholangiocytes, are susceptible to both apoptosis and necroptosis, which are triggered by distinct signal transduction pathways. Apoptosis is dependent on a proteolytic cascade of caspase enzymes, whereas necroptosis induction is caspase-independent. Moreover, different from the "silent" apoptotic cell death, necroptosis can cause a secondary inflammatory cascade, so-called necroinflammation, triggered by the release of various damage-associated molecular patterns (DAMPs). These DAMPs activate the innate immune system, leading to both local and systemic inflammatory responses, which can even cause remote organ failure. Therapeutic targeting of necroptosis by pharmacological inhibitors, such as necrostatin-1, shows variable effects in different disease models.

Published
2019

41. Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers

Author

Sandker, Maria J., Duque, Luisa F., Redout, Everaldo M., Chan, Alan, Que, Ivo, Löwik, Clemens W G M, Klijnstra, Evelien C., Kops, Nicole, Steendam, Rob, van Weeren, René, Hennink, Wim E., Weinans, Harrie, Pharmaceutics, Dep Gezondheidszorg Paard, LS Equine Muscoskeletal Biology, Afd Pharmaceutics, Orthopedics and Sports Medicine, Pharmaceutics, Dep Gezondheidszorg Paard, LS Equine Muscoskeletal Biology, and Afd Pharmaceutics

Subjects
Male, Magnetic Resonance Spectroscopy, Dispersity, Biocompatible Materials, 02 engineering and technology, 030226 pharmacology & pharmacy, Biochemistry, Biodegradable polymers, Injections, Intra-Articular, Polyethylene Glycols, Mice, 0302 clinical medicine, Materials Testing, Synovial Fluid, Membrane emulsification, Temperature, General Medicine, 021001 nanoscience & nanotechnology, Microspheres, Drug delivery, Biocompatibility, Swelling, medicine.symptom, 0210 nano-technology, Biotechnology, Materials science, Polyesters, Monodisperse microspheres, Biomedical Engineering, Fluorescence, Biomaterials, 03 medical and health sciences, In vivo, PEG ratio, medicine, Journal Article, Animals, Horses, Particle Size, Rats, Wistar, Molecular Biology, X-Ray Microtomography, Biodegradable polymer, Molecular Weight, Kinetics, Cartilage, Intra-articular, Anti-inflammatory, Biomedical engineering
Abstract

In this study, we investigated the use of microspheres with a narrow particle size distribution (‘monospheres’) composed of biodegradable poly(DL-lactide)-PEG-poly(DL-lactide)-b-poly(L-lactide) multiblock copolymers that are potentially suitable for local sustained drug release in articular joints. Monospheres with sizes of 5, 15 and 30 μm and a narrow particle size distribution were prepared by a micro-sieve membrane emulsification process. During in vitro degradation, less crystallinity, higher swelling and accelerated mass loss during was observed with increasing the PEG content of the polymer. The monospheres were tested in both a small (mice/rat) and large animal model (horse). In vivo imaging after injection with fluorescent dye loaded microspheres in mice knees showed that monospheres of all sizes retained within the joint for at least 90 days, while the same dose of free dye redistributed to the whole body within the first day after intra-articular injection. Administration of monospheres in equine carpal joints caused a mild transient inflammatory response without any clinical signs and without degradation of the cartilage, as evidenced by the absence of degradation products of sulfated glycosaminoglycans or collagen type 2 in the synovial fluid. The excellent intra-articular biocompatibility was confirmed in rat knees, where μCT-imaging and histology showed neither changes in cartilage quality nor quantity. Given the good intra-articular retention and the excellent biocompatibility, these novel poly(DL-lactide)-PEG-poly(DL-lactide)-b-poly(L-lactide)-based monospheres can be considered a suitable platform for intra-articular drug delivery. Statement of Significance This paper demonstrates the great potential in intra-articular drug delivery of monodisperse biodegradable microspheres which were prepared using a new class of biodegradable multi-block copolymers and a unique membrane emulsification process allowing the preparation of microspheres with a narrow particle size distribution (monospheres) leading to multiple advantages like better injectability, enhanced reproducibility and predictability of the in vivo release kinetics. We report not only on the synthesis and preparation, but also in vitro characterization, followed by in vivo testing of intra-articular biocompatibility of the monospheres in both a small and a large animal model. The favourable intra-articular biocompatibility combined with the prolonged intra-articular retention (>90 days) makes these monospheres an interesting drug delivery platform. What should also be highlighted is the use of horses; a very accurate translational model for the human situation, making the results not only relevant for equine healthcare, but also for the development of novel human OA therapies.

Published
2017

43. Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers

Author

Pharmaceutics, Dep Gezondheidszorg Paard, LS Equine Muscoskeletal Biology, Afd Pharmaceutics, Sandker, Maria J., Duque, Luisa F., Redout, Everaldo M., Chan, Alan, Que, Ivo, Löwik, Clemens W G M, Klijnstra, Evelien C., Kops, Nicole, Steendam, Rob, van Weeren, René, Hennink, Wim E., Weinans, Harrie, Pharmaceutics, Dep Gezondheidszorg Paard, LS Equine Muscoskeletal Biology, Afd Pharmaceutics, Sandker, Maria J., Duque, Luisa F., Redout, Everaldo M., Chan, Alan, Que, Ivo, Löwik, Clemens W G M, Klijnstra, Evelien C., Kops, Nicole, Steendam, Rob, van Weeren, René, Hennink, Wim E., and Weinans, Harrie

Published
2017

44. Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers

Author

Sandker, Maria J, Duque, Luisa F, Redout, Everaldo M, Chan, Alan, Que, Ivo, Löwik, Clemens W G M, Klijnstra, Evelien C, Kops, Nicole, Steendam, Rob, van Weeren, Rene, Hennink, Wim E, Weinans, Harrie, Sandker, Maria J, Duque, Luisa F, Redout, Everaldo M, Chan, Alan, Que, Ivo, Löwik, Clemens W G M, Klijnstra, Evelien C, Kops, Nicole, Steendam, Rob, van Weeren, Rene, Hennink, Wim E, and Weinans, Harrie

Published
2017

45. Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers

Author

Lab Reumatologie/Klinische Immunologie, Regenerative Medicine and Stem Cells, Orthopaedie Onderzoek, Sandker, Maria J, Duque, Luisa F, Redout, Everaldo M, Chan, Alan, Que, Ivo, Löwik, Clemens W G M, Klijnstra, Evelien C, Kops, Nicole, Steendam, Rob, van Weeren, Rene, Hennink, Wim E, Weinans, Harrie, Lab Reumatologie/Klinische Immunologie, Regenerative Medicine and Stem Cells, Orthopaedie Onderzoek, Sandker, Maria J, Duque, Luisa F, Redout, Everaldo M, Chan, Alan, Que, Ivo, Löwik, Clemens W G M, Klijnstra, Evelien C, Kops, Nicole, Steendam, Rob, van Weeren, Rene, Hennink, Wim E, and Weinans, Harrie

Published
2017

46. EGFR targeted nanobody-photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

Author

Van Driel, Pieter B A A, Boonstra, Martin C., Slooter, Maxime D., Heukers, Raimond, Stammes, Marieke A., Snoeks, Thomas J A, De Bruijn, Henriette S., Van Diest, Paul J., Vahrmeijer, Alexander L., Van Bergen En Henegouwen, Paul M P, Van De Velde, Cornelis J H, Löwik, Clemens W G M, Robinson, Dominic J., Oliveira, Sabrina, Van Driel, Pieter B A A, Boonstra, Martin C., Slooter, Maxime D., Heukers, Raimond, Stammes, Marieke A., Snoeks, Thomas J A, De Bruijn, Henriette S., Van Diest, Paul J., Vahrmeijer, Alexander L., Van Bergen En Henegouwen, Paul M P, Van De Velde, Cornelis J H, Löwik, Clemens W G M, Robinson, Dominic J., and Oliveira, Sabrina

Published
2016

47. EGFR targeted nanobody-photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

Author

Celbiologie, Pharmaceutics, Sub Cell Biology, Sub Drug delivery, van Driel, Pieter B A A, Boonstra, Martin C, Slooter, Maxime D, Heukers, Raimond, Stammes, Marieke A, Snoeks, Thomas J A, de Bruijn, Henriette S, van Diest, Paul J, Vahrmeijer, Alexander L, van Bergen En Henegouwen, Paul M P, van de Velde, Cornelis J H, Löwik, Clemens W G M, Robinson, Dominic J, Oliveira, Sabrina, Celbiologie, Pharmaceutics, Sub Cell Biology, Sub Drug delivery, van Driel, Pieter B A A, Boonstra, Martin C, Slooter, Maxime D, Heukers, Raimond, Stammes, Marieke A, Snoeks, Thomas J A, de Bruijn, Henriette S, van Diest, Paul J, Vahrmeijer, Alexander L, van Bergen En Henegouwen, Paul M P, van de Velde, Cornelis J H, Löwik, Clemens W G M, Robinson, Dominic J, and Oliveira, Sabrina

Published
2016

48. EGFR targeted nanobody-photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

Author

Pathologie Laboratorium diagnostiek, Pathologie, Cancer, Van Driel, Pieter B A A, Boonstra, Martin C., Slooter, Maxime D., Heukers, Raimond, Stammes, Marieke A., Snoeks, Thomas J A, De Bruijn, Henriette S., Van Diest, Paul J., Vahrmeijer, Alexander L., Van Bergen En Henegouwen, Paul M P, Van De Velde, Cornelis J H, Löwik, Clemens W G M, Robinson, Dominic J., Oliveira, Sabrina, Pathologie Laboratorium diagnostiek, Pathologie, Cancer, Van Driel, Pieter B A A, Boonstra, Martin C., Slooter, Maxime D., Heukers, Raimond, Stammes, Marieke A., Snoeks, Thomas J A, De Bruijn, Henriette S., Van Diest, Paul J., Vahrmeijer, Alexander L., Van Bergen En Henegouwen, Paul M P, Van De Velde, Cornelis J H, Löwik, Clemens W G M, Robinson, Dominic J., and Oliveira, Sabrina

Published
2016

49. EGFR targeted nanobody-photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

Author

Cell Biology, Neurobiology and Biophysics, Pharmaceutics, Sub Cell Biology, Sub Drug delivery, van Driel, Pieter B A A, Boonstra, Martin C, Slooter, Maxime D, Heukers, Raimond, Stammes, Marieke A, Snoeks, Thomas J A, de Bruijn, Henriette S, van Diest, Paul J, Vahrmeijer, Alexander L, van Bergen En Henegouwen, Paul M P, van de Velde, Cornelis J H, Löwik, Clemens W G M, Robinson, Dominic J, Oliveira, Sabrina, Cell Biology, Neurobiology and Biophysics, Pharmaceutics, Sub Cell Biology, Sub Drug delivery, van Driel, Pieter B A A, Boonstra, Martin C, Slooter, Maxime D, Heukers, Raimond, Stammes, Marieke A, Snoeks, Thomas J A, de Bruijn, Henriette S, van Diest, Paul J, Vahrmeijer, Alexander L, van Bergen En Henegouwen, Paul M P, van de Velde, Cornelis J H, Löwik, Clemens W G M, Robinson, Dominic J, and Oliveira, Sabrina

Published
2016

50. Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging

Author

Stammes, Marieke A, Knol-Blankevoort, Vicky T, Cruz, Luis J, Feitsma, Hans R I J, Mezzanotte, Laura, Cordfunke, Robert A, Sinisi, Riccardo, Dubikovskaya, Elena A, Maeda, Azusa, DaCosta, Ralph S, Bierau, Katja, Chan, Alan, Kaijzel, Eric L, Snoeks, Thomas J A, van Beek, Ermond R, Löwik, Clemens W G M, Stammes, Marieke A, Knol-Blankevoort, Vicky T, Cruz, Luis J, Feitsma, Hans R I J, Mezzanotte, Laura, Cordfunke, Robert A, Sinisi, Riccardo, Dubikovskaya, Elena A, Maeda, Azusa, DaCosta, Ralph S, Bierau, Katja, Chan, Alan, Kaijzel, Eric L, Snoeks, Thomas J A, van Beek, Ermond R, and Löwik, Clemens W G M

Abstract

PURPOSE: Recently we showed that a number of carboxylated near-infrared fluorescent (NIRF) cyanine dyes possess strong necrosis avid properties in vitro as well as in different mouse models of spontaneous and therapy-induced tumor necrosis, indicating their potential use for cancer diagnostic- and prognostic purposes. In the previous study, the detection of the cyanines was achieved by whole body optical imaging, a technique that, due to the limited penetration of near-infrared light, is not suitable for investigations deeper than 1 cm within the human body. Therefore, in order to facilitate clinical translation, the purpose of the present study was to generate a necrosis avid cyanine-based NIRF probe that could also be used for single photon emission computed tomography (SPECT). For this, the necrosis avid NIRF cyanine HQ4 was radiolabeled with 111indium, via the chelate diethylene triamine pentaacetic acid (DTPA).PROCEDURES: The necrosis avid properties of the radiotracer [111In]DTPA-HQ4 were examined in vitro and in vivo in different breast tumor models in mice using SPECT and optical imaging. Moreover, biodistribution studies were performed to examine the pharmacokinetics of the probe in vivo.RESULTS: Using optical imaging and radioactivity measurements, in vitro, we showed selective accumulation of [111In]DTPA-HQ4 in dead cells. Using SPECT and in biodistribution studies, the necrosis avidity of the radiotracer was confirmed in a 4T1 mouse breast cancer model of spontaneous tumor necrosis and in a MCF-7 human breast cancer model of chemotherapy-induced tumor necrosis.CONCLUSIONS: The radiotracer [111In]DTPA-HQ4 possessed strong and selective necrosis avidity in vitro and in various mouse models of tumor necrosis in vivo, indicating its potential to be clinically applied for diagnostic purposes and to monitor anti-cancer treatment efficacy.

Published
2016

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