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1. Dissociative Tendencies and Traffic Incidents

Author

Valle, Virginia, López, Soledad, Poó, Fernando M., and Montes, Silvana A.

Subjects
Dissociation, Driving, Traffic, Risk Factors, Philosophy. Psychology. Religion, Psychology, BF1-990
Abstract

This paper analyses the relationship between dissociative experiences and road traffic incidents (crashes and traffic tickets) in drivers (n=295) from Mar del Plata (Argentina) city. A self-report questionnaire was applied to assess traffic crash involvement and sociodemographic variables. Dissociative tendencies were assessed by a modified version of the DES scale. To examine differences in DES scores tests of the difference of means were applied. Drivers who reported to be previously involved in traffic incidents obtained higher puntuations in the dissociative experiences scale than drivers who did not report such events. This result is observed for the total scale and for the three sub-scales (absorption, amnesia and depersonalization). However, differences appeared mainly for minor damage collisions. Further studies are needed to evaluate the role of dissociative tendencies as a risk factor in road traffic safety.

Published
2012

5. Metodologías y experiencias de investigación en comunicación e información

Author

Carrillo-Durán, María Victoria, Faba-Pérez, Cristina, Pérez-Pulido, Margarita, Igartua-Perosanz, Juan José, Ruano-López, Soledad, Fernández-Falero, María del Rosario, Miranda, Sandra, González-Delgado, Ana, Trabadela-Robles, Javier, García-García, María, Herrera-Morillas, José-Luis, Caldes, Ana, Sequeiros, Paula, Thomas, Jérôme, Carrillo-Durán, María Victoria, Pérez-Pulido, Margarita, Carrillo-Durán, María Victoria, Faba-Pérez, Cristina, Pérez-Pulido, Margarita, Igartua-Perosanz, Juan José, Ruano-López, Soledad, Fernández-Falero, María del Rosario, Miranda, Sandra, González-Delgado, Ana, Trabadela-Robles, Javier, García-García, María, Herrera-Morillas, José-Luis, Caldes, Ana, Sequeiros, Paula, and Thomas, Jérôme

Subjects
AZ. None of these, but in this section.
Abstract

This work contextualizes the state of research in the areas of Communication Sciences and Information Sciences and presents new national and international methodological experiences that allow enriching the research experience of groups and lines of research developed in both thematic areas. The intersections between qualitative and quantitative methodologies, cases and ways of approaching research are explored, and new knowledge is provided both from studying the context of the situation and from the actual practices that allow opening doors and consolidating research in emerging areas, such as communication and information. The knowledge transfer carried out in this work is the result of the research work of consolidated research groups that carry out their research financed by public and private bodies of the first order and that are developed in Higher Education centres. The result is a volume directed at researchers and carried out by researchers who are looking for the intersection and collaboration in experiences that may allow the enrichment and progress of investigation.

Published
2020

6. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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21. Defective thyroid hormone transport to the brain leads to astroglial alterations

Author

Guillén-Yunta, Marina, primary, García-Aldea, Ángel, additional, Valcárcel-Hernández, Víctor, additional, Sanz-Bógalo, Ainara, additional, Muñoz-Moreno, Emma, additional, Matheus, Maria Gisele, additional, Grijota-Martínez, Carmen, additional, Bárez-López, Soledad, additional, Montero-Pedrazuela, Ana, additional, and Guadaño-Ferraz, Ana, additional

Published
2024
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24. Contributors

Author

Cortes, Carmen, primary, AboEllail, Mohamed Ahmed, additional, Ahkin Chin Tai, Janiel, additional, Ahumada-Juárez, Juan C., additional, Anderson, Peter J., additional, Andreu- Fernández, Vicente, additional, Antsaklis, Panagiotis, additional, Armstrong, R.A., additional, Ausó, Eva, additional, Avagliano, Laura, additional, Aye, Tandy, additional, Bassani, Silvia, additional, Bernardino, Inês, additional, Blanchett, Reid, additional, Blossom, Sarah J., additional, Bottini, Gabriella, additional, Bou Diab, Zeina, additional, Breit, Kristen R., additional, Bárez-López, Soledad, additional, Bulfamante, Gaetano P., additional, Castelo-Branco, Miguel, additional, Charney, Rebekah M., additional, Dale, Karina, additional, Daou, Arij, additional, Daskalakis, George, additional, De Asis-Cruz, Josepheen, additional, Deeb, George, additional, DeMaster, Dana, additional, De Miranda, Briana R., additional, Dias, Ronaldo P., additional, Drobnič Radobuljac, Maja, additional, Eguibar, Jose R., additional, Elkaim, Lior M., additional, Ellingsen, Ståle, additional, Fazzari, Pietro, additional, Fejzo, Marlena S., additional, Ferrón, Sacri R., additional, Finnell, Richard H., additional, Flores, Cecilia, additional, Foley, Patricia L., additional, Freeman, Jennifer L., additional, Galindo, Máximo Ibo, additional, García-Algar, Oscar, additional, García-Castro, Martín I., additional, George, Timothy M., additional, Gerlai, Robert, additional, Gloston, Gabrielle, additional, Gonçalves, Joana, additional, Granana, N., additional, Grazioli, Paolo, additional, Grijota-Martínez, Carmen, additional, Guadaño-Ferraz, Ana, additional, Guerrant, Richard L., additional, Hata, Toshiyuki, additional, Hernandez Gonzalez, Victor Hugo, additional, Holmbeck, Grayson N., additional, Ibrahim, George M., additional, Klamt, F., additional, Knickmeyer, Rebecca C., additional, Kohlmeier, Kristi A., additional, Komada, Munekazu, additional, Korzeniewski, Steven J., additional, Kurjak, Asim, additional, Limon, Danica, additional, Limperopoulos, Catherine, additional, Lozano-Ureña, Anna, additional, López del Castillo, Inés, additional, Malva, João O., additional, Manganas, Louis N., additional, Marini, Carla, additional, Masino, Mark A., additional, Massa, Valentina, additional, Maćkowiak, Marzena, additional, Medina–Alva, Pilar, additional, Mhanna, Rami, additional, Montero-Pedrazuela, Ana, additional, Montgomery, Jacob E., additional, Moore, Bartlett D., additional, Mullin, Patrick M., additional, Nicholson, Laura M., additional, Noda, Yoshihiro, additional, Nohejlová, Kateryna, additional, Ohanian, Diana M., additional, Oriá, Reinaldo B., additional, Ortinau, Cynthia, additional, Parodi, Chiara, additional, Parsons, R.B., additional, Pascoe, Leona, additional, Passafaro, Maria, additional, Perez, Mayra I., additional, Peviani, Valeria, additional, Piazza, Valeria, additional, Pinto, Daniel V., additional, Plemeniti Tololeski, Barbara, additional, Polli, Filip S., additional, Pollock, Shannon, additional, Prasad, Maneeshi S., additional, Preedy, Victor R., additional, Rajendram, Rajkumar, additional, Ramirez, Ana C., additional, Raposo, Ramon S., additional, Rasinger, Josef Daniel, additional, Reynolds, Lauren M., additional, Rodríguez-Prieto, Angela, additional, Romero Otalvaro, A.M., additional, Sailer, Sebastian, additional, Saliba, Jessica, additional, Scarpa, Pina, additional, Schneider, Sophie C., additional, Schonhofen, P., additional, Sebastiani, Giorgia, additional, Shaaban, Sherif G., additional, Shrestha, Merina, additional, Storch, Eric A., additional, Sustaíta, Michael A., additional, Terezakis, Stephanie A., additional, Šlamberová, Romana, additional, Vargas, D.M., additional, Vaughn, Kelly A., additional, Viana, Andres G., additional, Weinzimmer, Saira A., additional, Widerstrom-Noga, Eva, additional, Winning, Adrien M., additional, Wong, Marlon L., additional, Zegarra, Walter, additional, Zhou, Shao Jia, additional, and Zwicker, Jill G., additional

Published
2021
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27. Contributors

Author

Albert, Mareike, primary, Álvarez-Zaragoza, C., additional, Angulo, Brenda, additional, August, Pauline Maciel, additional, Ausó, Eva, additional, Barbosa, André Rocha, additional, Bartesaghi, Renata, additional, Bárez-López, Soledad, additional, Ben Bashat, Dafna, additional, Ben-Sira, Liat, additional, Bendas, Johanna, additional, Bibby, Christine, additional, Bigbee, John W., additional, Bitanihirwe, Byron K.Y., additional, Bourne, James A., additional, Bouyeure, Antoine, additional, Brentani, Helena, additional, Burbach, J. Peter H., additional, Burk, Joshua A., additional, Calabro, F.J., additional, Calegari de Toledo, Victor Hugo, additional, Cantor, Rita M., additional, Chiou, Brian, additional, Cogley, Clodagh, additional, Croy, Ilona, additional, Davila, Jorge, additional, Dickter, Cheryl L., additional, Diviccaro, Silvia, additional, D’Souza, Stephanie, additional, Dudink, Jeroen, additional, Enea-Drapeau, Claire, additional, Espinós, Carmen, additional, Faneyte, Sade J., additional, Feltrin, Arthur Sant’Anna, additional, Feys, Hilde, additional, Gallo, Gianluca, additional, García-Contreras, A.A., additional, Gaspari, Laura, additional, Giatti, Silvia, additional, Gilchrist, Courtney, additional, González-Barrios, Juan Antonio, additional, González-Maya, Marisel, additional, Grigore, Mihaela, additional, Grigore, Ana-Maria, additional, Grijota-Martínez, Carmen, additional, Gómez, Carlos M., additional, Guadaño-Ferraz, Ana, additional, Guidi, Sandra, additional, Himiniuc, Loredana-Maria, additional, Hoebeek, Freek E., additional, Hoffmann, Janine, additional, Hoffman, Kurt L., additional, Homman-Ludiye, Jihane, additional, Im, Kiho, additional, Žunić Išasegi, Iris, additional, Ishihara, Keiichi, additional, Jiménez-Estrada, Ismael, additional, Kancherla, Vijaya, additional, Katada, Tomohisa, additional, Katušić, Ana, additional, Kiani, Sahar, additional, Kim, Jeongtae, additional, Kirschen, Gregory W., additional, Kitada, Masaaki, additional, Klein, Caroline Peres, additional, Klingels, Katrijn, additional, Kobayashi, Shiori, additional, Kosaka, Yoshinori, additional, Kostović, Ivica, additional, Kostović Srzentić, Mirna, additional, Krsnik, Željka, additional, Lowe, Jennifer K., additional, López-Espíndola, Daniela, additional, Luna, B., additional, Lupo, Vincenzo, additional, Ma, Zilu, additional, Mailleux, Lisa, additional, Manganas, Louis N., additional, Martínez-Álvarez, Vladimir, additional, Maschietto, Mariana, additional, Matté, Cristiane, additional, McMillan, Nadia, additional, Melcangi, Roberto Cosimo, additional, Melo, Angel I., additional, Miller, Elka, additional, Mirsadeghi, Sara, additional, Mitchell, A.J., additional, Mitchell, Edwin A., additional, Mohamed, Esraa, additional, Monaghan, Ruth, additional, Montero-Pedrazuela, Ana, additional, Musket, C.W., additional, Noulhiane, Marion, additional, Numakawa, Tadahiro, additional, Odaka, Haruki, additional, Okabe, Akihito, additional, O’Keeffe, Fiadhnait, additional, Ortibus, Els, additional, Piao, Xianhua, additional, Quintá, Hector Ramiro, additional, Rea-Rosas, A., additional, Ren, Aiguo, additional, Rodríguez-Martínez, Elena I., additional, Rui, Liangyou, additional, Ruíz-Martínez, Francisco J., additional, Sakurai, Hiroyuki, additional, Sancho, Paula, additional, Sato-Bigbee, Carmen, additional, Selby, Matthew, additional, Sharma, Himanshu, additional, Shimizu-Okabe, Chigusa, additional, Simon-Martinez, Cristina, additional, Soyer-Gobillard, M.-O., additional, Stagni, Fiorenza, additional, Sullivan, Elinor L., additional, Sultan, Charles, additional, Sunagawa, Masanobu, additional, Tahira, Ana Carolina, additional, Takayama, Chitoshi, additional, Takeuchi, Akihito, additional, Taori, Abhijeet, additional, Taylor, Margot J., additional, Tervo-Clemmens, B., additional, Theis, Verena, additional, Theiss, Carsten, additional, Thompson, Deanne Kim, additional, Thompson, John M.D., additional, Toma, Bogdan Florin, additional, Tsao, Raphaele, additional, Urbain, Charline, additional, Vale Euclydes Colovati, Verônica Luiza, additional, Vásquez-Garibay, E.M., additional, Waldie, Karen E., additional, Wang, Linlin, additional, Woo, Tsung-Ung Wilson, additional, Yao, Paul, additional, Zempoalteca, René, additional, and Zhang, Nanyin, additional

Published
2021
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29. Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis

Author

Jimenez-Pacheco, Alba, Franco, Jaime M., Lopez, Soledad, Gomez-Zumaquero, Juan Miguel, Magdalena Leal-Lasarte, Maria, Caballero-Hernandez, Diana E., Cejudo-Guillén, Marta, Pozo, David, COHEN, IRUN, Series editor, Lajtha, Abel, Series editor, Lambris, John, Series editor, Paoletti, Rodolfo, Series editor, and Delgado-Morales, Raul, editor

Published
2017
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30. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Martínez-Sanz, Javier, primary, Díaz-Álvarez, Jorge, additional, Rosas Cancio-Suarez, Marta, additional, Ron, Raquel, additional, Iribarren, José Antonio, additional, Bernal, Enrique, additional, Gutiérrez, Félix, additional, Ruiz Sancho, Andrés, additional, Cabello, Noemi, additional, Olalla, Julián, additional, Moreno, Santiago, additional, Serrano-Villar, Sergio, additional, Jarrín, Inma, additional, Dalmau, David, additional, Navarro, M. Luisa, additional, González, M. Isabel, additional, Garcia, Federico, additional, Poveda, Eva, additional, Iribarren, Jose Antonio, additional, Rubio, Rafael, additional, Vidal, Francesc, additional, Berenguer, Juan, additional, González, Juan, additional, Muñoz-Fernández, M. Ángeles, additional, Jarrín, Inmaculada, additional, Moreno, Cristina, additional, Rava, Marta, additional, Izquierdo, Rebeca, additional, Mauleón, Elba, additional, Portilla, Joaquín, additional, Portilla, Irene, additional, Merino, Esperanza, additional, García, Gema, additional, Agea, Iván, additional, Sánchez-Payá, José, additional, Rodríguez, Juan Carlos, additional, Giner, Livia, additional, Reus, Sergio, additional, Boix, Vicente, additional, Torrus, Diego, additional, Pérez, Verónica, additional, Portilla, Julia, additional, Gómez, Juan Luís, additional, Hernández, Jehovana, additional, Lirola, Ana López, additional, García, Dácil, additional, Díaz-Flores, Felicitas, additional, Alonso, M. Mar, additional, Pelazas, Ricardo, additional, Alemán, M. Remedios, additional, Asensi, Víctor, additional, Rivas Carmenado, María Eugenia, additional, Suarez-Zarracina, Tomás, additional, Pulido, Federico, additional, Bisbal, Otilia, additional, Hernando, M. Asunción, additional, Rial, David, additional, de Lagarde, María, additional, Arce, Octavio, additional, Pinto, Adriana, additional, Bermejo, Laura, additional, Santacreu, Mireia, additional, Navarro, Roser, additional, Gonzalez, Candela, additional, Aramburu, M. José, additional, Camino, Xabier, additional, Ángel von Wichmann, Miguel, additional, Goenaga, Miguel Ángel, additional, Bustinduy, M. Jesús, additional, Azkune, Harkaitz, additional, Ibarguren, Maialen, additional, Kortajarena, Xabier, additional, Álvarez-Rodriguez, Ignacio, additional, Gil, Leire, additional, Martínez, Lourdes, additional, Robledano, Catalina, additional, Masiá, Mar, additional, Padilla, Sergio, additional, Adsuar, Araceli, additional, Pascual, Rafael, additional, Fernández, Marta, additional, Galiana, Antonio, additional, García, José Alberto, additional, Barber, Xavier, additional, Agullo, Vanessa, additional, Abellán, Javier Garcia, additional, Pascual, Reyes, additional, Telenti, Guillermo, additional, Guillén, Lucia, additional, Botella, Ángela, additional, Muga, Roberto, additional, Sanvisens, Arantza, additional, Fuster, Daniel, additional, Gutierrez, Isabel, additional, López, Juan Carlos, additional, Ramírez, Margarita, additional, Padilla, Belén, additional, Gijón, Paloma, additional, Aldamiz-Echevarría, Teresa, additional, Tejerina, Francisco, additional, Diez, Cristina, additional, Pérez, Leire, additional, Fanciulli, Chiara, additional, Corral, Saray, additional, Martí, Anna, additional, Peraire, Joaquín, additional, Viladés, Consuelo, additional, Vargas, Montserrat, additional, Olona, Montserrat, additional, Rull, Anna, additional, Alba, Verónica, additional, Yeregui, Elena, additional, Masip, Jenifer, additional, García-Pardo, Graciano, additional, Bertomeu, Frederic Gómez, additional, Espineira, Sonia, additional, Montero, Marta, additional, Cuéllar, Sandra, additional, Blanes, Marino, additional, Tasias, María, additional, Calabuig, Eva, additional, Salavert, Miguel, additional, Fernández, Juan, additional, Segarra, Inmaculada, additional, González-García, Juan, additional, Delgado, Ana, additional, Arnalich, Francisco, additional, Arribas, José Ramón, additional, Bernardino, Jose Ignacio, additional, Castro, Juan Miguel, additional, Escosa, Luis, additional, Herranz, Pedro, additional, Hontañón, Victor, additional, García-Bujalance, Silvia, additional, García, Milagros, additional, González-Baeza, Alicia, additional, Martín-Carbonero, M. Luz, additional, Mayoral, Mario, additional, Mellado, M. Jose, additional, Esteban, Rafael, additional, Montejano, Rocío, additional, Montes, M. Luisa, additional, Moreno, Victoria, additional, Pérez-Valero, Ignacio, additional, Rodés, Berta, additional, Rúa, Guadalupe, additional, Sainz, Talía, additional, Sendagorta, Elena, additional, Valencia, Eulalia, additional, Busca, Carmen, additional, Cano, Joanna, additional, Cardiñanos, Julen, additional, de Miguel, Rosa, additional, Blanco, Jose Ramón, additional, Pérez-Martínez, Laura, additional, Oteo, José Antonio, additional, Ibarra, Valvanera, additional, Metola, Luis, additional, Sanz, Mercedes, additional, Arazo, Piedad, additional, Sampériz, Gloria, additional, Martinez, Marina, additional, Jaén, Angels, additional, Sanmartí, Montse, additional, Cairó, Mireia, additional, Martinez-Lacasa, Javier, additional, Velli, Pablo, additional, Font, Roser, additional, Xercavins, Mariona, additional, Alonso, Noemí, additional, Aiello, Francesco, additional, Rivero, María, additional, Piérola, Beatriz, additional, Goikoetxea, Maider, additional, Gracia, María, additional, Ibero, Carlos, additional, Moreno, Estela, additional, Repáraz, Jesús, additional, Navarro, Gemma, additional, Garcia, Manel Cervantes, additional, Isbert, Sonia Calzado, additional, Vilasaro, Marta Navarro, additional, Garcia, Belen Lopez, additional, Santos, Ignacio de los, additional, Santos, Alejandro de los, additional, Sanz, Jesús, additional, García-Fraile, Lucio, additional, Martín, Enrique, additional, Sánchez-Cerrillo, Ildefonso, additional, Calvet, Marta, additional, Barrios, Ana, additional, Bautista, Azucena, additional, Sáez, Carmen, additional, Ciudad, Marianela, additional, Gutiérrez, Ángela, additional, Campo, Santos del, additional, Casado, José Luis, additional, Dronda, Fernando, additional, Moreno, Ana, additional, Pérez, M. Jesús, additional, Serrano, Sergio, additional, Vivancos, Ma Jesús, additional, Martínez-Sanz, Javier, additional, Vallejo, Alejandro, additional, Sanchez, Matilde, additional, Pérez-Molina, Jose Antonio, additional, Hermida, José Manuel, additional, Alcaraz, Antonia, additional, Bravo, Joaquín, additional, Muñoz, Ángeles, additional, Tomás, Cristina, additional, Martínez, Mónica, additional, Villalba, M. Carmen, additional, García, Federico, additional, Martínez, Clara, additional, Hernández, José, additional, Medina, Leopoldo Muñoz, additional, Álvarez, Marta, additional, Chueca, Natalia, additional, Vinuesa, David, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Guirao, Emilio, additional, Viñuela, Laura, additional, Ruiz-Sancho, Andrés, additional, Anguita, Francisco, additional, Del Romero, Jorge, additional, Raposo, Montserrat, additional, Rodríguez, Carmen, additional, Puerta, Teresa, additional, Carrió, Juan Carlos, additional, Vera, Mar, additional, Ballesteros, Juan, additional, Ayerdi, Oskar, additional, Baza, Begoña, additional, Orviz, Eva, additional, Antela, Antonio, additional, Losada, Elena, additional, Riera, Melchor, additional, Peñaranda, María, additional, Ribas, M. Angels, additional, Campins, Antoni A., additional, Garcia-Gazalla, Mercedes, additional, Fanjul, Francisco J., additional, Murillas, Javier, additional, Homar, Francisco, additional, Vilchez, Helem H., additional, Martin, Luisa, additional, Payeras, Antoni, additional, Santos, Jesús, additional, López, María, additional, Gómez, Crisitina, additional, Viciana, Isabel, additional, Palacios, Rosario, additional, López-Cortés, Luis Fernando, additional, Espinosa, Nuria, additional, Roca, Cristina, additional, Llaves, Silvia, additional, Tiraboschi, Juan Manuel, additional, Imaz, Arkaitz, additional, Silva, Ana Karina, additional, Saumoy, María, additional, Scévola, Sofía Catalina, additional, Curran, Adrián, additional, Falcó, Vicenç, additional, Navarro, Jordi, additional, Burgos, Joaquin, additional, Suanzes, Paula, additional, García, Jorge, additional, Descalzo, Vicente, additional, Álvarez, Patricia, additional, Planas, Bibiana, additional, Sanchiz, Marta, additional, Rodríguez, Lucía, additional, Sánchez, M José, additional, Pérez, Javier, additional, Arco, Alfonso del, additional, Torre, Javier de la, additional, Prada, José Luis, additional, Martínez, Onofre Juan, additional, Martinez, Lorena, additional, Vera, Francisco Jesús, additional, García, Josefina, additional, Alcaraz, Begoña, additional, Sánchez Guirao, Antonio Jesús, additional, Mena, Alvaro, additional, Castro, Angeles, additional, Pernas, Berta, additional, Vázquez, Pilar, additional, López, Soledad, additional, Ibarra, Sofía, additional, García, Guillermo, additional, Mirena, Josu, additional, Ferrero, Oscar Luis, additional, López, Josefina, additional, Cámara, M. Mar, additional, Peña, Mireia de la, additional, Lopez, Miriam, additional, Lopez, Iñigo, additional, Lombide, Itxaso, additional, Polo, Victor, additional, de Miguel, Joana, additional, Galera, Carlos, additional, Fernández, Marian, additional, Albendin, Helena, additional, Castillo, Antonia, additional, Iborra, Asunción, additional, Moreno, Antonio, additional, Merlos, M. Angustias, additional, Vidal, Asunción, additional, Amador, Concha, additional, Pasquau, Francisco, additional, Gil, Concepcion, additional, Algado, Jose Tomás, additional, Suarez-García, Inés, additional, Malmierca, Eduardo, additional, González-Ruano, Patricia, additional, Ruiz, M. Pilar, additional, Pascual, José Francisco, additional, Sáez, Elena, additional, Balsalobre, Luz, additional, López, M. Villa, additional, Omar, Mohamed, additional, Herrero, Carmen, additional, Gómez, M. Amparo, additional, Alberto de Zarraga, Miguel, additional, Pérez, Desiré, additional, Estrada, Vicente, additional, Sanz, Nieves, additional, Cabello, Noemí, additional, García, Jorge Vergas, additional, Núñez, Maria Jose, additional, Sagastagoitia, Iñigo, additional, Górgolas, Miguel, additional, Cabello, Alfonso, additional, Álvarez, Beatriz, additional, Prieto, Laura, additional, Carrillo, Irene, additional, Sanz, José, additional, Arranz, Alberto, additional, Hernández, Cristina, additional, Novella, María, additional, Galindo, M. José, additional, Ferrer, Ana, additional, Román, Antonio Rivero, additional, Ruíz, Inma, additional, Juárez, Antonio Rivero, additional, López, Pedro, additional, Machuca, Isabel, additional, Frias, Mario, additional, Camacho, Ángela, additional, Pérez, Ignacio, additional, Corona, Diana, additional, Cervero, Miguel, additional, Torres, Rafael, additional, Pineda, Juan Antonio, additional, Rincón, Pilar, additional, Macías, Juan, additional, Real, Luis Miguel, additional, Corma, Anais, additional, Gonzalez-Serna, Alejandro, additional, Pérez, Alexandre, additional, Morano, Luis, additional, Miralles, Celia, additional, Ocampo, Antonio, additional, Pousada, Guillermo, additional, Patiño, Lucía, additional, Dueñas, Carlos, additional, Gutiérrez, Sara, additional, Tapia, Elena, additional, Novoa, Cristina, additional, Egües, Xjoylin, additional, and Telleria, Pablo, additional

Published
2023
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33. Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction

Author

Neves, João Sérgio, primary, Leite, Ana Rita, additional, Conceição, Glória, additional, Gonçalves, Alexandre, additional, Borges-Canha, Marta, additional, Vale, Catarina, additional, Von-Hafe, Madalena, additional, Martins, Diana, additional, Miranda-Silva, Daniela, additional, Leite, Sara, additional, Rocha-Oliveira, Estela, additional, Sousa-Mendes, Cláudia, additional, Chaves, Joana, additional, Lourenço, Inês Mariana, additional, Grijota-Martínez, Carmen, additional, Bárez-López, Soledad, additional, Miranda, Isabel M., additional, Almeida-Coelho, João, additional, Vasques-Nóvoa, Francisco, additional, Carvalho, Davide, additional, Lourenço, André, additional, Falcão-Pires, Inês, additional, and Leite-Moreira, Adelino, additional

Published
2023
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36. Intracerebroventricular High Doses of 3,3′,5-Triiodothyroacetic Acid at Juvenile Stages Improve Peripheral Hyperthyroidism and Mediate Thyromimetic Effects in Limited Brain Regions in a Mouse Model of Monocarboxylate Transporter 8 Deficiency

Author

Grijota Martínez, María Carmen, Montero-Pedrazuela, Ana, Hidalgo-Álvarez, Jorge, Bárez-López, Soledad, Guadaño-Ferraz, Ana, Grijota Martínez, María Carmen, Montero-Pedrazuela, Ana, Hidalgo-Álvarez, Jorge, Bárez-López, Soledad, and Guadaño-Ferraz, Ana

Abstract

Introduction: Patients lacking functional monocarboxylate transporter 8 (MCT8), a highly specific thyroid hormone (TH) transporter, present severe psychomotor disabilities. MCT8 deficiency leads to peripheral hyperthyroidism and brain hypothyroidism, the latter due to impaired transport of TH across brain barriers. Available treatments for patients are limited and aim to overcome the limited TH transport across brain barriers. The use of TH analogues such as 3,3′,5-triiodothyroacetic acid (TRIAC) that do not require MCT8 to cross the cellular membranes is considered a potential therapy for MCT8 deficiency. Previous studies have shown that systemic administration of TRIAC at therapeutic doses does not increase TRIAC content in the brain, while intracerebroventricular (ICV) administration of therapeutic doses of TRIAC increases TRIAC content in the brain but does not mediate thyromimetic effects. In view of this, we hypothesize that ICV administration of high doses of TRIAC can mediate thyromimetic effects in the brain without worsening the brain hypothyroidism or peripheral hyperthyroidism of patients. Methods: We administered 400 ng/g of body weight per day of ICV TRIAC in a mouse model of MCT8 deficiency: Mct8−/y and deiodinase 2 (Dio2)−/− double knockout mice. The effects of this treatment on TH and TRIAC levels/content in blood and tissues were determined by radioimmunoassay and effects on TH-regulated genes were assessed by real time-quantitative polymerase chain reaction in peripheral and central tissues. Results: ICV administration of high doses of TRIAC ameliorated the peripheral hyperthyroidism. In the brain, this treatment did not further aggravate brain hypothyroidism and increased TRIAC content in several brain regions; however, only moderate thyromimetic activity was observed in restricted brain areas. Conclusion: Administration of high doses of TRIAC by ICV delivery at juvenile stages in a mouse model of MCT8 deficiency is effective in normalizing perip, Depto. de Biología Celular, Fac. de Ciencias Biológicas, TRUE, pub

Published
2023

37. Body Mass Index and its relationship with Motor Skills

Author

Jiménez López, Soledad, Robles Orué, Jorge, Salcedo Carrasco, Francisca, Guadalupe Álvarez, Ronal Hugo, Huamaní Riveros, Marco Antonio, Jiménez López, Soledad, Robles Orué, Jorge, Salcedo Carrasco, Francisca, Guadalupe Álvarez, Ronal Hugo, and Huamaní Riveros, Marco Antonio

Abstract

This research deals with the Body Mass Index and its relationship with the Motor Skills of elementary school students in the town of Chosica. The problem is that there are many children who are overweight or obese, this increases more and more diseases associated with sedentary lifestyle, called Noncommunicable Diseases (NCDs) such as obesity, heart disease, stroke, cancer, respiratory diseases Chronicles and diabetes. The methodology consists of a transversal correlated descriptive study for which the anthropometric measurement was made to determine the Body Mass Index (BMI) and the MOTOR GRAMI TEST 2, of Ruiz, LM, Rioja, N., Graupera, JL, Palomino, M. and García, V. to determine motor competence, these instruments were applied to a sample of 120 students between 10 and 12 years of educational institutions in Chosica. Obtaining the following result: 1. A highly significant multiple correlation has been found between the motor skills and the (IMC), 2. A positive and highly significant relationship has been found between the motor competence "race of 30 meters" and the (BMI)), 3. A positive and significant relationship has not been found between the motor competition "medical ball throwing" and the (IMC), 4. A positive relationship has been found and highly significant between the motor competence «Jump 7 meters to the lame leg» and the (IMC), 5. A positive and significant relationship has been found between the competition motor «Lateral leaps» and (BMI), 6. A positive and highly significant relationship has been found between the motor competence «Round-trip» and (BMI), and 7. A positive and significant relationship has been found between the motor competence «Displacement on supports» and the (IMC)., Esta investigación trata sobre el Índice de Masa Corporal y su relación con las Competencias Motrices de los estudiantes de educación primaria de la localidad de Chosica. El problema es que existe muchos niños con sobrepeso o eran obesos. Esto hace que se incremente cada vez más enfermedades asociadas al sedentarismo, denominadas Enfermedades No Transmisibles (ENT) como la obesidad, las enfermedades cardíacas, los accidentes cerebrovasculares, el cáncer, las enfermedades respiratorias crónicas y la diabetes. La metodología consiste en un estudio descriptivo correlacionado transversal, para lo cual se hizo la medición antropométrica con el fin de determinar el Índice de Masa Corporal (IMC) y el TEST MOTOR GRAMI – 2, de Ruiz, L.M., Rioja, N., Graupera, J.L., Palomino, M. y García, V. para determinar la competencia motriz. Dichos instrumentos fueron aplicados a una muestra de 120 estudiantes entre 10 a 12 años de las Instituciones Educativas de Chosica. Se obtuvo el siguiente resultado: 1. Se ha encontrado una correlación múltiple altamente significativa entre las competencias motrices y el (IMC), 2. Se ha encontrado una relación positiva y altamente significativa entre la competencia motriz «carrera de 30 metros» y el (IMC), 3. No se ha encontrado una relación positiva y significativa entre la competencia motriz «lanzamiento de balón medicinal» y el (IMC), 4. Se ha encontrado una relación positiva y altamente significativa entre la competencia motriz «Saltar 7 metros a la pata coja» y el (IMC), 5. Se ha encontrado una relación positiva y significativa entre la competencia motriz «Saltos laterales» y (IMC), 6. Se ha encontrado una relación positiva y altamente significativa entre la competencia motriz «Carrera de ida-vuelta» y el (IMC), y 7. Se ha encontrado  una  relación  positiva  y  significativa  entre  la  competencia  motriz «Desplazamiento sobre soportes» y el (IMC).

Published
2023

38. Maternal Administration of the CNS-Selective Sobetirome Prodrug Sob-AM2 Exerts Thyromimetic Effects in Murine MCT8-Deficient Fetuses

Author

Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Consejo Superior de Investigaciones Científicas (España), Sherman Foundation, Valcárcel-Hernández, Víctor, Guillen-Yunta, M., Scanlan, Thomas S., Bárez-López, Soledad, Guadaño-Ferraz, Ana, Ministerio de Ciencia e Innovación (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Consejo Superior de Investigaciones Científicas (España), Sherman Foundation, Valcárcel-Hernández, Víctor, Guillen-Yunta, M., Scanlan, Thomas S., Bárez-López, Soledad, and Guadaño-Ferraz, Ana

Abstract

[Background]: Monocarboxylate transporter 8 (MCT8) deficiency is a rare X-linked disease where patients exhibit peripheral hyperthyroidism and cerebral hypothyroidism, which results in severe neurological impairments. These brain defects arise from a lack of thyroid hormones (TH) during critical stages of human brain development. Treatment options for MCT8-deficient patients are limited and none have been able to prevent or ameliorate effectively the neurological impairments. This study explored the effects of the TH agonist sobetirome and its CNS-selective amide prodrug, Sob-AM2, in the treatment of pregnant dams carrying fetuses lacking Mct8 and deiodinase type 2 (Mct8/Dio2 KO), as a murine model for MCT8 deficiency. [Methods]: Pregnant dams carrying Mct8/Dio2 KO fetuses were treated with 1 mg of sobetirome/kg body weight/day, or 0.3 mg of Sob-AM2/kg body weight/day for 7 days, starting at embryonic day 12.5 (E12.5). As controls, pregnant dams carrying wild-type and pregnant dams carrying Mct8/Dio2 KO fetuses were treated with daily subcutaneous injections of vehicle. Dams TH levels were measured by enzyme-linked immunosorbent assay (ELISA). Samples were extracted at E18.5 and the effect of treatments on the expression of triiodothyronine (T3)-dependent genes was measured in the placenta, fetal liver, and fetal cerebral cortex by real-time polymerase chain reaction. [Results]: Maternal sobetirome treatment led to spontaneous abortions. Sob-AM2 treatment, however, was able to cross the placental as well as the brain barriers and exert thyromimetic effects in Mct8/Dio2 KO fetal tissues. Sob-AM2 treatment did not affect the expression of the T3-target genes analyzed in the placenta, but it mediated thyromimetic effects in the fetal liver by increasing the expression of Dio1 and Dio3 genes. Interestingly, Sob-AM2 treatment increased the expression of several T3-dependent genes in the brain such as Hr, Shh, Dio3, Kcnj10, Klf9, and Faah in Mct8/Dio2 KO fetuses. [Conclus

Published
2023

39. Intracerebroventricular High Doses of 3,3′,5-Triiodothyroacetic Acid at Juvenile Stages Improve Peripheral Hyperthyroidism and Mediate Thyromimetic Effects in Limited Brain Regions in a Mouse Model of Monocarboxylate Transporter 8 Deficiency

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Consejo Superior de Investigaciones Científicas (España), Sherman Foundation, Grijota Martínez, María del Carmen, Montero-Pedrazuela, Ana, Hidalgo-Álvarez, Jorge, Bárez-López, Soledad, Guadaño-Ferraz, Ana, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Consejo Superior de Investigaciones Científicas (España), Sherman Foundation, Grijota Martínez, María del Carmen, Montero-Pedrazuela, Ana, Hidalgo-Álvarez, Jorge, Bárez-López, Soledad, and Guadaño-Ferraz, Ana

Abstract

[Introduction]: Patients lacking functional monocarboxylate transporter 8 (MCT8), a highly specific thyroid hormone (TH) transporter, present severe psychomotor disabilities. MCT8 deficiency leads to peripheral hyperthyroidism and brain hypothyroidism, the latter due to impaired transport of TH across brain barriers. Available treatments for patients are limited and aim to overcome the limited TH transport across brain barriers. The use of TH analogues such as 3,3′,5-triiodothyroacetic acid (TRIAC) that do not require MCT8 to cross the cellular membranes is considered a potential therapy for MCT8 deficiency. Previous studies have shown that systemic administration of TRIAC at therapeutic doses does not increase TRIAC content in the brain, while intracerebroventricular (ICV) administration of therapeutic doses of TRIAC increases TRIAC content in the brain but does not mediate thyromimetic effects. In view of this, we hypothesize that ICV administration of high doses of TRIAC can mediate thyromimetic effects in the brain without worsening the brain hypothyroidism or peripheral hyperthyroidism of patients. [Methods]: We administered 400 ng/g of body weight per day of ICV TRIAC in a mouse model of MCT8 deficiency: Mct8−/y and deiodinase 2 (Dio2)−/− double knockout mice. The effects of this treatment on TH and TRIAC levels/content in blood and tissues were determined by radioimmunoassay and effects on TH-regulated genes were assessed by real time-quantitative polymerase chain reaction in peripheral and central tissues. [Results]: ICV administration of high doses of TRIAC ameliorated the peripheral hyperthyroidism. In the brain, this treatment did not further aggravate brain hypothyroidism and increased TRIAC content in several brain regions; however, only moderate thyromimetic activity was observed in restricted brain areas. [Conclusion]: Administration of high doses of TRIAC by ICV delivery at juvenile stages in a mouse model of MCT8 deficiency is effective in normalizi

Published
2023

40. Isoflurane Rapidly Modifies Synaptic and Cytoskeletal Phosphoproteomes of the Supraoptic Nucleus of the Hypothalamus and the Cortex

Author

Biotechnology and Biological Sciences Research Council (UK), Leverhulme Trust, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), British Heart Foundation, Bárez-López, Soledad, Gadd, George J., Pauža, Audrys G., Murphy, David, Greenwood, Michael P., Biotechnology and Biological Sciences Research Council (UK), Leverhulme Trust, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), British Heart Foundation, Bárez-López, Soledad, Gadd, George J., Pauža, Audrys G., Murphy, David, and Greenwood, Michael P.

Abstract

[Introduction]: Despite the widespread use of general anaesthetics, the mechanisms mediating their effects are still not understood. Although suppressed in most parts of the brain, neuronal activity, as measured by FOS activation, is increased in the hypothalamic supraoptic nucleus (SON) by numerous general anaesthetics, and evidence points to this brain region being involved in the induction of general anaesthesia (GA) and natural sleep. Posttranslational modifications of proteins, including changes in phosphorylation, enable fast modulation of protein function which could be underlying the rapid effects of GA. In order to identify potential phosphorylation events in the brain-mediating GA effects, we have explored the phosphoproteome responses in the rat SON and compared these to cingulate cortex (CC) which displays no FOS activation in response to general anaesthetics., [Methods]: Adult Sprague-Dawley rats were treated with isoflurane for 15 min. Proteins from the CC and SON were extracted and processed for nano-LC mass spectrometry (LC-MS/MS). Phosphoproteomic determinations were performed by LC-MS/MS., [Results]: We found many changes in the phosphoproteomes of both the CC and SON in response to 15 min of isoflurane exposure. Pathway analysis indicated that proteins undergoing phosphorylation adaptations are involved in cytoskeleton remodelling and synaptic signalling events. Importantly, changes in protein phosphorylation appeared to be brain region specific suggesting that differential phosphorylation adaptations might underlie the different neuronal activity responses to GA between the CC and SON., [Conclusion]: In summary, these data suggest that rapid posttranslational modifications in proteins involved in cytoskeleton remodelling and synaptic signalling events might mediate the central mechanisms mediating GA.

Published
2023

47. The Audiovisual Content Downloads among University Students = Las descargas de contenidos audiovisuales en Internet entre estudiantes universitarios

Author

Duarte-Hueros, Juliana, Duarte-Hueros, Ana, and Ruano-López, Soledad

Subjects
BJ. Communication, G. Industry, profession and education., GH. Education.
Abstract

This article analyses the phenomenon of downloading audio-visual content –movies and television series– which is habitually practiced by university students via the Internet; their attitudes towards illegal downloads; and the education/training that they have about the legal status of this activity. These issues are a frequent reality but are little discussed in our academic context. Data was obtained from a questionnaire designed ad hoc. This was administered to students enrolled in different university degrees (Audio-visual Communication, Primary Education and Social Education). We believe that these college degrees require ethical and legal training on the issues regarding downloading of content from the web. This education is an urgently needed training for young people who will work in educating and informing the citizens of the 21st century. The study results show that university students habitually consume a high percentage of online content from the audio-visual industry (films and television series). Students have clearly favourable attitudes towards this form of consumption. However, students show little regards to the ethical and legal issues surrounding downloading from the Internet. In addition, they have a very low degree of education and training on these issues. The results suggest the need to implement training programs and to conduct information campaigns to improve their information and digital literacy.

Published
2016

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