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754 results on '"Lo, Kwok-Wai"'

1. Synthetic BZLF1-targeted transcriptional activator for efficient lytic induction therapy against EBV-associated epithelial cancers

Author

Wu, Man, Hau, Pok Man, Li, Linxian, Tsang, Chi Man, Yang, Yike, Taghbalout, Aziz, Chung, Grace Tin-Yun, Hui, Shin Yee, Tang, Wing Chung, Jillette, Nathaniel, Zhu, Jacqueline Jufen, Lee, Horace Hok Yeung, Kong, Ee Ling, Chan, Melissa Sue Ann, Chan, Jason Ying Kuen, Ma, Brigette Buig Yue, Chen, Mei-Ru, Lee, Charles, To, Ka Fai, Cheng, Albert Wu, and Lo, Kwok-Wai

Published
2024
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3. Multi-Scale Attention-based Multiple Instance Learning for Classification of Multi-Gigapixel Histology Images

Author

Wibawa, Made Satria, Lo, Kwok-Wai, Young, Lawrence, and Rajpoot, Nasir

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence, Computer Science - Machine Learning
Abstract

Histology images with multi-gigapixel of resolution yield rich information for cancer diagnosis and prognosis. Most of the time, only slide-level label is available because pixel-wise annotation is labour intensive task. In this paper, we propose a deep learning pipeline for classification in histology images. Using multiple instance learning, we attempt to predict the latent membrane protein 1 (LMP1) status of nasopharyngeal carcinoma (NPC) based on haematoxylin and eosin-stain (H&E) histology images. We utilised attention mechanism with residual connection for our aggregation layers. In our 3-fold cross-validation experiment, we achieved average accuracy, AUC and F1-score 0.936, 0.995 and 0.862, respectively. This method also allows us to examine the model interpretability by visualising attention scores. To the best of our knowledge, this is the first attempt to predict LMP1 status on NPC using deep learning.

Published
2022

5. Multi-scale Attention-Based Multiple Instance Learning for Classification of Multi-gigapixel Histology Images

Author

Wibawa, Made Satria, Lo, Kwok-Wai, Young, Lawrence S., Rajpoot, Nasir, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Karlinsky, Leonid, editor, Michaeli, Tomer, editor, and Nishino, Ko, editor

Published
2023
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6. MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling.

Author

Ngan, Hoi-Lam, Liu, Yuchen, Fong, Andrew Yuon, Poon, Peony Hiu Yan, Yeung, Chun Kit, Chan, Sharon Suet Man, Lau, Alexandria, Piao, Wenying, Li, Hui, Tse, Jessie Sze Wing, Lo, Kwok-Wai, Chan, Sze Man, Su, Yu-Xiong, Chan, Jason Ying Kuen, Lau, Chin Wang, Mills, Gordon B, Grandis, Jennifer Rubin, and Lui, Vivian Wai Yan

Abstract

MAPK pathway mutations affect one-fifth of head and neck squamous cell carcinoma (HNSCC). Unexpectedly, MAPK pathway aberrations are associated with remarkably long patient survival, even among patients with TP53 mutations (median ∼14 yr). We explored underlying outcome-favoring mechanisms with omics followed by preclinical models. Strikingly, multiple hotspot and non-hotspot MAPK mutations (A/BRAF, HRAS, MAPK1, and MAP2K1/2) all abrogated ErbB3 activation, a well-established HNSCC progression signal. Inhibitor studies functionally defined ERK activity negatively regulating phospho-ErbB3 in MAPK-mutants. Furthermore, pan-pathway immunoprofiling investigations identified MAPK-mutant tumors as the only "CD8+ T-cell-inflamed" tumors inherently bearing high-immunoreactive, constitutive cytolytic tumor microenvironments. Immunocompetent MAPK-mutant HNSCC models displayed active cell death and massive CD8+ T-cell recruitment in situ. Consistent with CD8+ T-inflamed phenotypes, MAPK-mutant HNSCC patients, independent of tumor-mutational burden, survived 3.3-4 times longer than WT patients with anti-PD1/PD-L1 immunotherapies. Similar prognosticity was noted in pan-cancers. We uncovered clinical, signaling, and immunological uniqueness of MAPK-mutant HNSCC with potential biomarker utilities predicting favorable patient survival.

Published
2020

7. Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma.

Author

Lin, Weitao, Yip, Yim Ling, Jia, Lin, Deng, Wen, Zheng, Hong, Dai, Wei, Ko, Josephine Mun Yee, Lo, Kwok Wai, Chung, Grace Tin Yun, Yip, Kevin Y, Lee, Sau-Dan, Kwan, Johnny Sheung-Him, Zhang, Jun, Liu, Tengfei, Chan, Jimmy Yu-Wai, Kwong, Dora Lai-Wan, Lee, Victor Ho-Fun, Nicholls, John Malcolm, Busson, Pierre, Liu, Xuefeng, Chiang, Alan Kwok Shing, Hui, Kwai Fung, Kwok, Hin, Cheung, Siu Tim, Cheung, Yuk Chun, Chan, Chi Keung, Li, Bin, Cheung, Annie Lai-Man, Hau, Pok Man, Zhou, Yuan, Tsang, Chi Man, Middeldorp, Jaap, Chen, Honglin, Lung, Maria Li, and Tsao, Sai Wah

Subjects
Cell Line, Tumor, Animals, Mice, Inbred NOD, Humans, Mice, SCID, Herpesvirus 4, Human, Virion, Protein Kinase Inhibitors, Xenograft Model Antitumor Assays, Phylogeny, Virus Activation, Mutation, Genes, Viral, Adult, Aged, Middle Aged, Female, Male, rho-Associated Kinases, Nasopharyngeal Carcinoma, Cell Line, Tumor, Genes, Viral, Herpesvirus 4, Human, Mice, Inbred NOD, SCID
Abstract

The lack of representative nasopharyngeal carcinoma (NPC) models has seriously hampered research on EBV carcinogenesis and preclinical studies in NPC. Here we report the successful growth of five NPC patient-derived xenografts (PDXs) from fifty-eight attempts of transplantation of NPC specimens into NOD/SCID mice. The take rates for primary and recurrent NPC are 4.9% and 17.6%, respectively. Successful establishment of a new EBV-positive NPC cell line, NPC43, is achieved directly from patient NPC tissues by including Rho-associated coiled-coil containing kinases inhibitor (Y-27632) in culture medium. Spontaneous lytic reactivation of EBV can be observed in NPC43 upon withdrawal of Y-27632. Whole-exome sequencing (WES) reveals a close similarity in mutational profiles of these NPC PDXs with their corresponding patient NPC. Whole-genome sequencing (WGS) further delineates the genomic landscape and sequences of EBV genomes in these newly established NPC models, which supports their potential use in future studies of NPC.

Published
2018

8. Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Author

Bruce, Jeff P., To, Ka-Fai, Lui, Vivian W. Y., Chung, Grace T. Y., Chan, Yuk-Yu, Tsang, Chi Man, Yip, Kevin Y., Ma, Brigette B. Y., Woo, John K. S., Hui, Edwin P., Mak, Michael K. F., Lee, Sau-Dan, Chow, Chit, Velapasamy, Sharmila, Or, Yvonne Y. Y., Siu, Pui Kei, El Ghamrasni, Samah, Prokopec, Stephenie, Wu, Man, Kwan, Johnny S. H., Liu, Yuchen, Chan, Jason Y. K., van Hasselt, C. Andrew, Young, Lawrence S., Dawson, Christopher W., Paterson, Ian C., Yap, Lee-Fah, Tsao, Sai-Wah, Liu, Fei-Fei, Chan, Anthony T. C., Pugh, Trevor J., and Lo, Kwok-Wai

Published
2022
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11. OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps

Author

Li, Le, Leung, Alden King-Yung, Kwok, Tsz-Piu, Lai, Yvonne YY, Pang, Iris K, Chung, Grace Tin-Yun, Mak, Angel CY, Poon, Annie, Chu, Catherine, Li, Menglu, Wu, Jacob JK, Lam, Ernest T, Cao, Han, Lin, Chin, Sibert, Justin, Yiu, Siu-Ming, Xiao, Ming, Lo, Kwok-Wai, Kwok, Pui-Yan, Chan, Ting-Fung, and Yip, Kevin Y

Subjects
Computational Biology, Computer Simulation, Genome, Human, Genomic Structural Variation, Genomics, Humans, Software, Optical mapping, Nanochannel, Single-molecule analysis, Structural variation, Environmental Sciences, Biological Sciences, Information and Computing Sciences, Bioinformatics
Abstract

We present a new method, OMSV, for accurately and comprehensively identifying structural variations (SVs) from optical maps. OMSV detects both homozygous and heterozygous SVs, SVs of various types and sizes, and SVs with or without creating or destroying restriction sites. We show that OMSV has high sensitivity and specificity, with clear performance gains over the latest method. Applying OMSV to a human cell line, we identified hundreds of SVs >2 kbp, with 68 % of them missed by sequencing-based callers. Independent experimental validation confirmed the high accuracy of these SVs. The OMSV software is available at http://yiplab.cse.cuhk.edu.hk/omsv/ .

Published
2017

13. Ice Melt, Sea Level Rise and Superstorms: Evidence from Paleoclimate Data, Climate Modeling, and Modern Observations that 2{\deg}C Global Warming is Dangerous

Author

Hansen, James, Sato, Makiko, Hearty, Paul, Ruedy, Reto, Kelley, Maxwell, Masson-Delmotte, Valerie, Russell, Gary, Tselioudis, George, Cao, Junji, Rignot, Eric, Velicogna, Isabella, Tormey, Blair, Donovan, Bailey, Kandiano, Evgeniya, von Schuckmann, Karina, Kharecha, Pushker, Legrande, Allegra N., Bauer, Michael, and Lo, Kwok-Wai

Subjects
Physics - Atmospheric and Oceanic Physics
Abstract

We use numerical climate simulations, paleoclimate data, and modern observations to study the effect of growing ice melt from Antarctica and Greenland. Meltwater tends to stabilize the ocean column, inducing amplifying feedbacks that increase subsurface ocean warming and ice shelf melting. Cold meltwater and induced dynamical effects cause ocean surface cooling in the Southern Ocean and North Atlantic, thus increasing Earth's energy imbalance and heat flux into most of the global ocean's surface. Southern Ocean surface cooling, while lower latitudes are warming, increases precipitation on the Southern Ocean, increasing ocean stratification, slowing deepwater formation, and increasing ice sheet mass loss. These feedbacks make ice sheets in contact with the ocean vulnerable to accelerating disintegration. We hypothesize that ice mass loss from the most vulnerable ice, sufficient to raise sea level several meters, is better approximated as exponential than by a more linear response. Doubling times of 10, 20 or 40 years yield multi-meter sea level rise in about 50, 100 or 200 years. Recent ice melt doubling times are near the lower end of the 10-40 year range, but the record is too short to confirm the nature of the response. The feedbacks, including subsurface ocean warming, help explain paleoclimate data and point to a dominant Southern Ocean role in controlling atmospheric CO2, which in turn exercised tight control on global temperature and sea level. The millennial (500-2000 year) time scale of deep ocean ventilation affects the time scale for natural CO2 change and thus the time scale for paleo global climate, ice sheet, and sea level changes, but this paleo millennial time scale should not be misinterpreted as the time scale for ice sheet response to a rapid large human-made climate forcing., Comment: 78 pages, 58 figures; submitted to Atmos. Chem. Phys

Published
2016
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16. Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations.

Author

Li, Yvonne Y, Chung, Grace TY, Lui, Vivian WY, To, Ka-Fai, Ma, Brigette BY, Chow, Chit, Woo, John KS, Yip, Kevin Y, Seo, Jeongsun, Hui, Edwin P, Mak, Michael KF, Rusan, Maria, Chau, Nicole G, Or, Yvonne YY, Law, Marcus HN, Law, Peggy PY, Liu, Zoey WY, Ngan, Hoi-Lam, Hau, Pok-Man, Verhoeft, Krista R, Poon, Peony HY, Yoo, Seong-Keun, Shin, Jong-Yeon, Lee, Sau-Dan, Lun, Samantha WM, Jia, Lin, Chan, Anthony WH, Chan, Jason YK, Lai, Paul BS, Fung, Choi-Yi, Hung, Suet-Ting, Wang, Lin, Chang, Ann Margaret V, Chiosea, Simion I, Hedberg, Matthew L, Tsao, Sai-Wah, van Hasselt, Andrew C, Chan, Anthony TC, Grandis, Jennifer R, Hammerman, Peter S, and Lo, Kwok-Wai

Subjects
Humans, Herpesvirus 4, Human, Epstein-Barr Virus Infections, Carcinoma, Nasopharyngeal Neoplasms, TNF Receptor-Associated Factor 3, NF-kappa B, Viral Matrix Proteins, Signal Transduction, Cell Proliferation, Mutation, Genome, Human, Exome, NF-KappaB Inhibitor alpha, Whole Genome Sequencing, Deubiquitinating Enzyme CYLD, Nasopharyngeal Carcinoma, Genome, Human, Herpesvirus 4
Abstract

Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC genomic data hinders the understanding of NPC biology, disease progression and rational therapy design. Here we performed whole-exome sequencing (WES) on 111 micro-dissected EBV-positive NPCs, with 15 cases subjected to further whole-genome sequencing (WGS), to determine its mutational landscape. We identified enrichment for genomic aberrations of multiple negative regulators of the NF-κB pathway, including CYLD, TRAF3, NFKBIA and NLRC5, in a total of 41% of cases. Functional analysis confirmed inactivating CYLD mutations as drivers for NPC cell growth. The EBV oncoprotein latent membrane protein 1 (LMP1) functions to constitutively activate NF-κB signalling, and we observed mutual exclusivity among tumours with somatic NF-κB pathway aberrations and LMP1-overexpression, suggesting that NF-κB activation is selected for by both somatic and viral events during NPC pathogenesis.

Published
2017

17. Supplementary Table 4 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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18. Supplementary Figure 2 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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19. Supplementary Methods from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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20. Supplementary Figure 7 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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21. Supplementary Figure 6 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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22. Supplementary Figure 4 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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23. Supplementary Table 7 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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24. Supplementary Table 6 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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25. Supplementary Table 8 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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26. Supplementary Table 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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27. Supplementary Table 3 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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28. Supplementary Figure 3 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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29. Supplementary Figure 5 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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30. Supplementary Table 5 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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31. TABLE 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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32. Supplementary Table 9 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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33. Supplementary Table 2 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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35. Reactivation of Epstein–Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn 2+ -chelating function

Author

Jiang, Lijun, Lung, Hong Lok, Huang, Tao, Lan, Rongfeng, Zha, Shuai, Chan, Lai Sheung, Thor, Waygen, Tsoi, Tik-Hung, Chau, Ho-Fai, Boreström, Cecilia, Cobb, Steven L., Tsao, Sai Wah, Bian, Zhao-Xiang, Law, Ga-Lai, Wong, Wing-Tak, Tai, William Chi-Shing, Chau, Wai Yin, Du, Yujun, Tang, Lucas Hao Xi, Chiang, Alan Kwok Shing, Middeldorp, Jaap M., Lo, Kwok-Wai, Mak, Nai Ki, Long, Nicholas J., and Wong, Ka-Leung

Published
2019

37. Ice melt, sea level rise and superstorms: evidence from paleoclimate data, climate modeling, and modern observations that 2 ∘C global warming could be dangerous

Author

Hansen, James, Sato, Makiko, Hearty, Paul, Ruedy, Reto, Kelley, Maxwell, Masson-Delmotte, Valerie, Russell, Gary, Tselioudis, George, Cao, Junji, Rignot, Eric, Velicogna, Isabella, Tormey, Blair, Donovan, Bailey, Kandiano, Evgeniya, von Schuckmann, Karina, Kharecha, Pushker, Legrande, Allegra N, Bauer, Michael, and Lo, Kwok-Wai

Subjects
Earth Sciences, Oceanography, Physical Geography and Environmental Geoscience, Geology, Climate Action, physics.ao-ph, Astronomical and Space Sciences, Atmospheric Sciences, Meteorology & Atmospheric Sciences, Atmospheric sciences, Climate change science
Abstract

We use numerical climate simulations, paleoclimate data, and modern observations to study the effect of growing ice melt from Antarctica and Greenland. Meltwater tends to stabilize the ocean column, inducing amplifying feedbacks that increase subsurface ocean warming and ice shelf melting. Cold meltwater and induced dynamical effects cause ocean surface cooling in the Southern Ocean and North Atlantic, thus increasing Earth's energy imbalance and heat flux into most of the global ocean's surface. Southern Ocean surface cooling, while lower latitudes are warming, increases precipitation on the Southern Ocean, increasing ocean stratification, slowing deepwater formation, and increasing ice sheet mass loss. These feedbacks make ice sheets in contact with the ocean vulnerable to accelerating disintegration. We hypothesize that ice mass loss from the most vulnerable ice, sufficient to raise sea level several meters, is better approximated as exponential than by a more linear response. Doubling times of 10, 20 or 40 years yield multi-meter sea level rise in about 50, 100 or 200 years. Recent ice melt doubling times are near the lower end of the 10-40-year range, but the record is too short to confirm the nature of the response. The feedbacks, including subsurface ocean warming, help explain paleoclimate data and point to a dominant Southern Ocean role in controlling atmospheric CO2, which in turn exercised tight control on global temperature and sea level. The millennial (500-2000-year) timescale of deep-ocean ventilation affects the timescale for natural CO2 change and thus the timescale for paleo-global climate, ice sheet, and sea level changes, but this paleo-millennial timescale should not be misinterpreted as the timescale for ice sheet response to a rapid, large, human-made climate forcing. These climate feedbacks aid interpretation of events late in the prior interglacial, when sea level rose to +6-9 m with evidence of extreme storms while Earth was less than 1 °C warmer than today. Ice melt cooling of the North Atlantic and Southern oceans increases atmospheric temperature gradients, eddy kinetic energy and baroclinicity, thus driving more powerful storms. The modeling, paleoclimate evidence, and ongoing observations together imply that 2 °C global warming above the preindustrial level could be dangerous. Continued high fossil fuel emissions this century are predicted to yield (1) cooling of the Southern Ocean, especially in the Western Hemisphere; (2) slowing of the Southern Ocean overturning circulation, warming of the ice shelves, and growing ice sheet mass loss; (3) slowdown and eventual shutdown of the Atlantic overturning circulation with cooling of the North Atlantic region; (4) increasingly powerful storms; and (5) nonlinearly growing sea level rise, reaching several meters over a timescale of 50-150 years. These predictions, especially the cooling in the Southern Ocean and North Atlantic with markedly reduced warming or even cooling in Europe, differ fundamentally from existing climate change assessments. We discuss observations and modeling studies needed to refute or clarify these assertions.

Published
2016

38. FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential

Author

Zhang, Jinglin, Wong, Chi Chun, Leung, Kam Tong, Wu, Feng, Zhou, Yuhang, Tong, Joanna H. M., Chan, Ronald C. K., Li, Hui, Wang, Yifei, Yan, Huan, Liu, Liping, Wu, William K. K., Chan, Michael W. Y., Cheng, Alfred S. L., Yu, Jun, Wong, Nathalie, Lo, Kwok Wai, To, Ka Fai, and Kang, Wei

Published
2020
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41. Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

Author

Lechner, Matt, Schartinger, Volker H., Steele, Christopher D., Nei, Wen Long, Ooft, Marc Lucas, Schreiber, Liesa-Marie, Pipinikas, Christodoulos P., Chung, Grace Tin-Yun, Chan, Yuk Yu, Wu, Feng, To, Ka-Fai, Tsang, Chi Man, Pearce, Wayne, Morelli, Daniele, Philpott, Martin, Masterson, Liam, Nibhani, Reshma, Wells, Graham, Bell, Christopher G., Koller, Julia, Delecluse, Susanne, Yip, Yim Ling, Liu, Jacklyn, Forde, Cillian T., Forster, Martin D., Jay, Amrita, Dudás, József, Krapp, Annika, Wan, Simon, Uprimny, Christian, Sprung, Susanne, Haybaeck, Johannes, Fenton, Tim R., Chester, Kerry, Thirlwell, Christina, Royle, Gary, Marafioti, Teresa, Gupta, Rajeev, Indrasari, Sagung Rai, Herdini, Camelia, Slim, Mohd Afiq Mohd, Indrawati, I., Sutton, Liam, Fles, Renske, Tan, Bing, Yeong, Joe, Jain, Amit, Han, Shuting, Wang, Haitao, Loke, Kelvin S. H., He, Wan, Xu, Ruilian, Jin, Hongtao, Cheng, Zhiqiang, Howard, David, Hwang, Peter H., Le, Quynh-Thu, Tay, Joshua K., West, Robert B., Tsao, Sai Wah, Meyer, Tim, Riechelmann, Herbert, Oppermann, Udo, Delecluse, Henri-Jacques, Willems, Stefan M., Chua, Melvin L. K., Busson, Pierre, Lo, Kwok Wai, Wollmann, Guido, Pillay, Nischalan, Vanhaesebroeck, Bart, and Lund, Valerie J.

Published
2021
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42. Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Author

Bruce, Jeff P., To, Ka-Fai, Lui, Vivian W. Y., Chung, Grace T. Y., Chan, Yuk-Yu, Tsang, Chi Man, Yip, Kevin Y., Ma, Brigette B. Y., Woo, John K. S., Hui, Edwin P., Mak, Michael K. F., Lee, Sau-Dan, Chow, Chit, Velapasamy, Sharmila, Or, Yvonne Y. Y., Siu, Pui Kei, El Ghamrasni, Samah, Prokopec, Stephenie, Wu, Man, Kwan, Johnny S. H., Liu, Yuchen, Chan, Jason Y. K., van Hasselt, C. Andrew, Young, Lawrence S., Dawson, Christopher W., Paterson, Ian C., Yap, Lee-Fah, Tsao, Sai-Wah, Liu, Fei-Fei, Chan, Anthony T. C., Pugh, Trevor J., and Lo, Kwok-Wai

Published
2021
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43. STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker

Author

Chen, Bonan, Chan, Wai Nok, Mui, Chun Wai, Liu, Xiaoli, Zhang, Jinglin, Wang, Yifei, Cheung, Alvin H. K., Chan, Aden K. Y., Chan, Ronald C. K., Leung, Kam Tong, Dong, Yujuan, Pan, Yi, Ke, Huixing, Liang, Li, Zhou, Zhaocai, Wong, Chi Chun, Wu, William K. K., Cheng, Alfred S. L., Yu, Jun, Lo, Kwok Wai, To, Ka Fai, and Kang, Wei

Published
2021
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46. Establishment and characterization of an Epstein-Barr virus-positive cell line from a non-keratinizing differentiated primary nasopharyngeal carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, additional, Lee, Hui Mei, additional, Abdul Aziz, Norazlin, additional, Yee, Pei San, additional, Marzuki, Marini, additional, Wong, Ka Wo, additional, Chiang, Alan K.S., additional, Chow, Larry Ka-Yue, additional, Dai, Wei, additional, Liu, Teng Fei, additional, Tan, Lu Ping, additional, Khoo, Alan Soo Beng, additional, Lo, Kwok Wai, additional, Lim, Paul VH, additional, Rajadurai, Pathmanathan, additional, Lightfoot, Howard, additional, Barthorpe, Syd, additional, Garnett, Mathew J, additional, and Cheong, Sok Ching, additional

Published
2024
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47. The molecular classification of cancer‐associated fibroblasts on a pan‐cancer single‐cell transcriptional atlas

Author

Chen, Bonan, primary, Chan, Wai Nok, additional, Xie, Fuda, additional, Mui, Chun Wai, additional, Liu, Xiaoli, additional, Cheung, Alvin H. K., additional, Lung, Raymond W. M., additional, Chow, Chit, additional, Zhang, Zhenhua, additional, Fang, Canbin, additional, Yu, Peiyao, additional, Shi, Shihua, additional, Zhou, Shikun, additional, Chen, Guoming, additional, Wang, Zhangding, additional, Wang, Shouyu, additional, Ding, Xiaofan, additional, Huang, Bing, additional, Liang, Li, additional, Dong, Yujuan, additional, Wong, Chi Chun, additional, Wu, William K. K., additional, Cheng, Alfred S. L., additional, Wong, Nathalie, additional, Yu, Jun, additional, Lo, Kwok Wai, additional, Tse, Gary M. K., additional, Kang, Wei, additional, and To, Ka Fai, additional

Published
2023
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50. Accurate identification of structural variations from cancer samples

Author

Li, Le, primary, Hong, Chenyang, additional, Xu, Jie, additional, Chung, Claire Yik-Lok, additional, Leung, Alden King-Yung, additional, Boncan, Delbert Almerick T, additional, Cheng, Lixin, additional, Lo, Kwok-Wai, additional, Lai, Paul B S, additional, Wong, John, additional, Zhou, Jingying, additional, Cheng, Alfred Sze-Lok, additional, Chan, Ting-Fung, additional, Yue, Feng, additional, and Yip, Kevin Y, additional

Published
2023
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