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19 results on '"Lo, Hang Hong"'

8. Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice

Author

Song, Lin Lin, Qu, Yuan Qing, Tang, Yong Pei, Chen, Xi, Lo, Hang Hong, Qu, Li Qun, Yun, Yun Xiao, Wong, Vincent Kam Wai, Zhang, Rui Long, Wang, Hui Miao, Liu, Meng Han, Zhang, Wei, Zhang, Hui Xia, Chan, Joyce Tsz Wai, Wang, Cai Ren, Wu, Jian Hui, and Law, Betty Yuen Kwan

Published
2023
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10. Tumor Therapeutic Modes

Author

Peng, Yu Zhong, Yang, Li Jun, Lo, Hang Hong, Law, Betty Yuen Kwan, Wong, Vincent Kam Wai, Huang, Rongqin, editor, and Wang, Yi, editor

Published
2020
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13. Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response.

Author

Zeng, Yaling, Ng, Jerome P. L., Wang, Linna, Xu, Xiongfei, Law, Betty Yuen Kwan, Chen, Guobing, Lo, Hang Hong, Yang, Lijun, Yang, Jiujie, Zhang, Lei, Qu, Liqun, Yun, Xiaoyun, Zhong, Jing, Chen, Ruihong, Zhang, Dingqi, Wang, Yuping, Luo, Weidan, Qiu, Congling, Huang, Baixiong, and liu, Wenfeng

Subjects
EXPERIMENTAL arthritis, IMMUNE response, T helper cells, KNEE joint, RHEUMATOID arthritis, ARTHRITIS
Abstract

Background: Rheumatoid arthritis (RA) is an autoimmune inflammation disease characterized by imbalance of immune homeostasis. p53 mutants are commonly described as the guardian of cancer cells by conferring them drug-resistance and immune evasion. Importantly, p53 mutations have also been identified in RA patients, and this prompts the investigation of its role in RA pathogenesis. Methods: The cytotoxicity of disease-modifying anti-rheumatic drugs (DMARDs) against p53 wild-type (WT)/mutant-transfected RA fibroblast-like synoviocytes (RAFLSs) was evaluated by MTT assay. Adeno-associated virus (AAV) was employed to establish p53 WT/R211* adjuvant-induced arthritis (AIA) rat model. The arthritic condition of rats was assessed by various parameters such as micro-CT analysis. Knee joint samples were isolated for total RNA sequencing analysis. The expressions of cytokines and immune-related genes were examined by qPCR, ELISA assay and immunofluorescence. The mechanistic pathway was determined by immunoprecipitation and Western blotting in vitro and in vivo. Results: Among p53 mutants, p53R213* exhibited remarkable DMARD-resistance in RAFLSs. However, AAV-induced p53R211* overexpression ameliorated inflammatory arthritis in AIA rats without Methotrexate (MTX)-resistance, and our results discovered the immunomodulatory effect of p53R211* via suppression of T-cell activation and T helper 17 cell (Th17) infiltration in rat joint, and finally downregulated expressions of pro-inflammatory cytokines. Total RNA sequencing analysis identified the correlation of p53R211* with immune-related pathways. Further mechanistic studies revealed that p53R213*/R211* instead of wild-type p53 interacted with TANK-binding kinase 1 (TBK1) and suppressed the innate immune TBK1–Interferon regulatory factor 3 (IRF3)–Stimulator of interferon genes (STING) cascade. Conclusions: This study unravels the role of p53R213* mutant in RA pathogenesis, and identifies TBK1 as a potential anti-inflammatory target. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy

Author

Ren, Fang, Tan, Ming, Jerome P L, Ng, Wu, An Guo, Yuan, Si Yu, Zhang, Hui, Ren, Ji Hua, Cheng, Sheng Tao, Zhang, Juan, Lo, Hang Hong, Vincent Kam Wai, Wong, Betty Yuen Kwan, Law, and Chen, Juan

Subjects
Pharmacology, Virology
Abstract

Hepatitis B surface antigen (HBsAg) loss and seroconversion are considered as an end point of a functional cure. Therefore, it is crucial to find new agents which could efficiently decrease HBsAg. Traditional herbal plants have been considered as an important source of new hepatitis B drugs development for their extensive use in antimicrobial and anti-inflammation. In this study, Peristrophe japonica, which could remarkably reduce HBsAg in the supernatant of HepG2.2.15 cells, was screened out for further extraction. Here, an active ethyl acetate fraction of Peristrophe japonica containing 34 sub-fractions was extracted. Subsequently, the monomeric compound Ciliatoside A was isolated and identified as a potential antiviral reagent with low cytotoxicity from Fraction 30. Ciliatoside A exhibited strong inhibition on intracellular and circulating HBsAg and HBV RNAs in HBV-infected cells and an HBV recombinant-cccDNA mouse model. The mechanistic study revealed that Ciliatoside A exhibited a potent anti-HBV effect through inducing autophagy-lysosomal pathway to autophagic degradation of HBc by activating AMPK-ULK1 axis and inhibiting mTOR activation. In summary, we have identified a novel antiviral compound Ciliatoside A isolated from Peristrophe japonica. This study may provide important direction and new ideas for the discovery of hepatitis B cure drugs.

Published
2023
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18. Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota

Author

Zeng, Wu, primary, Wu, An Guo, additional, Zhou, Xiao-Gang, additional, Khan, Imran, additional, Zhang, Rui Long, additional, Lo, Hang Hong, additional, Qu, Li Qun, additional, Song, Lin Lin, additional, Yun, Xiao Yun, additional, Wang, Hui Miao, additional, Chen, Juan, additional, Ng, Jerome P.L., additional, Ren, Fang, additional, Yuan, Si Yu, additional, Yu, Lu, additional, Tang, Yong, additional, Huang, Guo Xin, additional, Wong, Vincent Kam Wai, additional, Chung, Sookja Kim, additional, Mok, Simon Wing Fai, additional, Qin, Da Lian, additional, Sun, Hua Lin, additional, Liu, Liang, additional, Hsiao, W.L. Wendy, additional, and Law, Betty Yuen Kwan, additional

Published
2021
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