8,287 results on '"Lloyd, R"'
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2. Past and future river bank trend assessment of lower Cagayan River, Philippines
- Author
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Felipe, Alvin John B., Alejo, Lanie A., Padre, Rafael J., and Bareng, Jeoffrey Lloyd R.
- Published
- 2024
- Full Text
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3. The transition of WRRF models to digital twin applications
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Torfs, Elena, primary, Nicolaï, Niels, additional, Daneshgar, Saba, additional, Copp, John B., additional, Haimi, Henri, additional, Ikumi, David, additional, Johnson, Bruce, additional, Plosz, Benedek B., additional, Snowling, Spencer, additional, Townley, Lloyd R., additional, Valverde-Pérez, Borja, additional, Vanrolleghem, Peter A., additional, Vezzaro, Luca, additional, and Nopens, Ingmar, additional
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- 2024
- Full Text
- View/download PDF
4. Consistent solutions for simultaneous dynamic water, solute, stable isotope and radon balances to estimate average exchange fluxes between surface water bodies and groundwater
- Author
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Townley, Lloyd R. and Turner, Jeffrey V.
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- 2024
- Full Text
- View/download PDF
5. Geological and geochemical characterization of caprock integrity in the Athabasca oilsands region
- Author
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Huang, Haiping, Chen, Zhuoheng, Silva, Renzo C., Jiang, Chunqing, Snowdon, Lloyd R., and Larter, Steve
- Published
- 2024
- Full Text
- View/download PDF
6. Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations
- Author
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Zuckerman, Jamie T., Jackson, Asia Sage, Minko, Irina G., Kant, Melis, Jaruga, Pawel, Stone, Michael P., Dizdaroglu, Miral, McCullough, Amanda K., and Lloyd, R. Stephen
- Published
- 2024
- Full Text
- View/download PDF
7. Review on molecular structures of asphaltene macromolecules and instrumental analytical approaches
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Zhirong ZHANG, Guoliang TAO, Lloyd R SNOWDON, John K VOLKMAN, and Yan'e CHEN
- Subjects
asphaltene ,macro-molecular structure ,archipelago model ,island model ,molecular weight ,polarity ,Geophysics. Cosmic physics ,QC801-809 ,Geology ,QE1-996.5 - Abstract
As one of the major fractions of petroleum and/or source rock extracts, asphaltene is commonly characte-rized by complicate molecular structures as well as relatively higher molecular weight (MW). The asphaltene occluded biomarkers have been well introduced to be valuable for geochemical research whilst the actual molecular weight and molecular structures of asphaltene macromolecules studies show value in petroleum exploration and production, laboratory treatments as well as petroleum chemical storage and transportation etc. The structure, molecular weight and related experimental measurement methods of asphaltenes reported in this paper are reviewed, in an attempt to provide a more comprehensive understanding on the molecular structure, molecular weight and physicochemical properties of asphaltenes, so as to provide basic data for applying asphaltene geochemical research in the exploration and development study of conventional and unconventional reservoirs. In view of the different views on the structure and molecular weight of asphaltene molecules, the results are reviewed, the main reasons for the controversy are discussed based on the current status of experimental measurement technology, and the future development trend of related researches is pointed out. The current understanding of the structure of asphaltene macromolecules is mainly based on two completely different models, i.e., the island model and archipelago model. The former suggests that asphaltenes have a single aromatic nucleus and the molecular weight characterized is relatively lower. The latter believes that asphaltenes have multiple aromatic nuclei and the molecular weight characterized is relatively higher. The above two models of asphaltene molecular structure are supported by their own experimental measurement results, among which the evidences of the "island" model mainly come from fluorescence spectroscopy, laser vaporization/laser ionization mass spectrometry (L2MS) analysis and stem from various ionization high-resolution (Fourier transform ion cyclotron resonance mass spectrometry, FT-ICR-MS) analysis technologies. The evidences for the archipelago model mainly come from gas phase permeation measurement, size exclusion chromatography and chemical degradation.
- Published
- 2023
- Full Text
- View/download PDF
8. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, H, Abu-Arafeh, A, Abubacker, S, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, S, Acheampong, P, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adati, K, Adcock, K, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, F, Adesemoye, O, Adewunmi, E, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikary, R, Aditya, A, Adkins, G, Adnan, A, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Aftab, Z, Agarwal, M, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Ahamed Sadiq, S, Ahammed Nazeer, M, Ahmed, A, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmad, M, Ahmed, N, Ahmed, O, Ahmed, R, Ahmad, S, Ahmed, S H, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, A, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Alegria, A, Alexander, C, Alexander, J, Alexander, P, Al-Fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, F, Ali, J, Ali, M, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Aliyuda, F, Alizaedeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, L, Allen, P, Allen, R, Allen, S, Allen, T, Alli, A, Allison, K, Allman, B, Allsup, D, Allsop, H, Allsop, L, Almahroos, A, Al-Moasseb, H, Al-Obaidi, M, Alomari, L, Al-Rabahi, A, Al-Ramadhani, B, Al-Saadi, Z, Al-Sammarraie, R, Alshaer, I, Al-Shahi Salman, R, Al-Shamkhani, W, Alsheikh, F, Al-Sheklly, B, Altaf, S, Alty, A, Alvarez, M, Alvarez Corral, M, Alveyn, E, Alzetani, M, Amamou, S, Amar, N, Ambalavanan, S, Ambrogetti, R, Ambrose, C, Ameen, A, Ames, K, Amin, A, Amin, K, Amin, S, Amin, T, Amit, B, Amjad, A, Amjad, N, Amosun, V, Amsal, M, Amsha, K, Amutio Martin, N, Amy, P, Anada, A, Anand, A, Anandappa, S, Anantapatnaikuni, S, Anderson, E, Anderson, J, Anderson, L, Anderson, M, Anderson, N, Anderson, R, Anderson, S, Anderson, W, Andreou, P, Andrews, A, Andrews, J, Aneke, K, Ang, A, Ang, W, Angel, T, Angela, A, Angelini, P, Anguvaa, L, Anichtchik, O, Anim-Somuah, M, Aniruddhan, K, Annett, J, Anning, L, Anstey, P, Anstey, R, Anthony, A, Anthony-Pillai, A, Antill, P, Antonnia, Z, Anu, V, Anwar, M, Apetri, E, Apostolopoulos, A, Appleby, S, Appleyard, D, Aquino, M, Araba, B, Aransiola, S, Araujo, M, Archer, A, Archer, D, Archer, S, Arcoria, D, Ardley, C, Arias, A, Aribike, O, Arimoto, R, Armata, I, Armistead, J, Armitage, A, Armstrong, C, Armstrong, M, Armstrong, S, Armstrong, W, Armtrong, P, Arndt, H, Arnison-Newgass, C, Arnold, D, Arnold, R, Arnott, A, Arora, D, Arora, R, Arora, K, Arora, P, Arter, A, Arumaithurai, A, Arya, A, Arya, R, Asandei, D, Asghar, M, Ashab, M, Ashbrook-Raby, C, Ashby, H, Ashcroft, J, Ashcroft, S, Asher, G, Ashfak, Z, Ashfaq, A, Ashish, A, Ashley, D, Ashman-Flavell, S, Ashok, S, Ashour, A, Ashraf, S, Ashraf, M, Ashraq, M, Ashton, D, Ashton, S, Ashworth, A, Ashworth, F, Ashworth, R, Aslam, A, Aslam, I, Aslam, S, Aslett, L, Asogan, H, Asrar, A, Assaf, O, Astin-Chamberlain, R, Athorne, D, Atkins, B, Atkins, C, Atkins, S, Atkinson, J, Atkinson, V, Atomode, A, Atraskiewicz, B, Attia, A, Attubato, E, Attwood, M, Auer, Z, Aujayeb, A, Aung, A, Aung, H, Aung, K, Aung, N, Aung, Y, Aung, Z, Austin, E, Austin, K, Auwal, A, Avari, M, Avery, M, Aveyard, N, Avis, J, Aviss, G, Avram, C, Avram, P, Awadelkareem, A, Awadzi, G, Awaly, M, Awan, A, Awoseyila, A, Aya, A, Ayaz, E, Ayers, A, Azam, J, Azeem, A, Azharuddin, M, Aziz, A, Aziz, G, Aziz, I, Aziz, N, Azkoul, A, Azman Shah, A, Azzopardi, G, Azzoug, H, Babatunde, F, Babi, M, Babiker, B, Babington, G, Babirecki, M, Babores, M, Babs-Osibodu, A, Bacciarelli, S, Bachar, R, Bachour, M, Bacon, G, Bacon, J, Badal, B, Bader, M, Badhan, G, Badhrinarayanan, S, Bae, J, Baggaley, A, Baggott, A, Bagmane, D, Bagshaw, L, Bahadori, K, Bailey, A, Bailey, J, Bailey, K, Bailey, L, Bailey, M, Bailey, P, Bailey, S, Baillie, H, Baillie, J, Bain, J, Bains, V, Baird, D, Baird, E, Baird, S, Baird, T, Baird, Y, Bajandouh, A, Baker, D, Baker, E, Baker, J, Baker, K, Baker, M, Baker, R, Baker, T, Baker, V, Bakere, H, Bakerly, N, Baker-Moffatt, M, Bakhai, A, Bakhtiar, N, Bakoulas, P, Bakthavatsalam, D, Balachandran, N, Balan, A, Balasingam, P, Balaskas, T, Balasubramania, M, Balatoni, N, Balcombe, A, Baldwin, A, Baldwin, C, Baldwin, D, Baldwin, F, Baldwin-Jones, R, Bale, N, Balfour, J, Ball, R, Ball, M, Ballard, K, Balluz, I, Balmforth, C, Balogh, E, Baltmr, A, Baluwala, A, Bambridge, G, Bamford, P, Bamford, A, Bamgboye, A, Bancroft, H, Bancroft, E, Banda, J, Bandaru, K, Bandla, N, Bandyopadhyam, S, Banerjee, A, Banerjee, R, Bani-Saad, O, Banks, H, Banks, L, Banks, P, Bann, C, Bannister, H, Bannister, O, Banton, L, Baptist, M, Baqai, T, Baral, A, Baramova, D, Barbe, R, Barbon, E, Barbosa, M, Barbour, J, Barclay, A, Barclay, C, Bardsley, G, Bareford, S, Bari, S, Barker, A, Barker, D, Barker, E, Barker, H, Barker, J, Barker, L, Barker, O, Barkha, S, Barla, J, Barlow, G, Barlow, R, Barlow, V, Barnacle, J, Barnes, D, Barnes, N, Barnes, R, Barnes, T, Barnetson, C, Barnett, A, Barnett-Vanes, A, Barnsley, W, Barr, A, Barr, C, Barr, D, Barr, J, Barratt, N, Barratt, S, Barrera, M, Barrett, A, Barrett, F, Barrett, J, Barrett, S, Barrow, E, Bartlett, C, Bartlett, G, Bartlett, J, Bartlett, L, Bartley, S, Bartolmeu-Pires, S, Barton, A, Barton, G, Barton, L, Barton, R, Baruah, R, Baryschpolec, S, Bashir, H, Bashyal, A, Basker, B, Basran, A, Bassett, G, Bassett, J, Bassford, C, Bassoy, B, Bastion, V, Basumatary, A, Basvi, P, Bataduwaarachchi, V, Bate, T, Bateman, H, Bateman, K, Bateman, V, Bates, E, Bates, H, Bates, M, Bates, S, Batham, S, Batista, A, Batla, A, Batra, D, Batty, A, Batty, H, Batty, T, Baum, M, Baumbe, R, Bautista, C, Bawa, T, Bawa, F, Bawani, F, Bax, S, Baxter, M, Baxter, N, Baxter, Z, Bayes, H, Bayo, L-A, Bazari, F, Bazaz, R, Bazli, A, Beacham, L, Beadles, W, Beadon, K, Beak, P, Beale, A, Beard, K, Beardsal, K, Bearpark, J, Beasley, A, Beattie, S, Beaumont, K, Beaver, T, Beavis, S, Beazley, C, Beck, S, Beckett, V, Beckitt, R, Beckley, S, Beddall, H, Beeby, D, Beeby, S, Beech, G, Beecroft, M, Beer, S, Beer, N, Bega, G, Begg, A, Begg, S, Beghini, S, Begum, A, Begum, S, Behan, T, Behrouzi, R, Beishon, J, Beith, C, Belcher, J, Belfield, H, Belfield, K, Belgaumkar, A, Bell, D, Bell, G, Bell, J, Bell, L, Bell, N, Bell, P, Bell, S, Bellamu, J, Bellamy, M, Bellamy, T, Bellini, A, Bellis, A, Bellis, F, Bendall, L, Benesh, N, Benetti, N, Benham, L, Benison-Horner, G, Benkenstein, S, Benn, T, Bennett, A, Bennett, C, Bennett, D, Bennett, G, Bennett, K, Bennett, L, Bennett, M, Bennett, S, Bennion, K, Benoy, G, Benson, V, Bentley, A, Bentley, J, Benton, I, Beranova, E, Beresford, M, Bergin, C, Bergstrom, M, Berriman, T, Berry, Z, Best, K, Best, F, Bester, A, Beuvink, Y, Bevan, E, Bevins, S, Bewick, T, Bexley, A, Beyatli, S, Beynon, F, Bhadi, A, Bhagani, S, Bhakta, S, Bhalla, R, Bhandal, K, Bhandari, A, Bhandari, S, Bhanich Supapol, J, Bhanot, A, Bhanot, R, Bhasin, S, Bhat, A, Bhat, P, Bhatnagar, R, Bhatt, K, Bhayani, J, Bhojwani, D, Bhuie, P, Bhuiyan, S, Bibby, A, Bibi, F, Bibi, N, Bibi, S, Bicanic, T, Bidgood, S, Bigg, J, Biggs, S, Biju, A, Bikov, A, Billingham, S, Billings, J, Binns, A, BinRofaie, M, Bintcliffe, O, Birch, J, Birchall, K, Bird, S, Birt, M, Bishop, C, Bishop, K, Bishop, L, Bisnauthsing, K, Biswas, N, Biuk, S, Blachford, K, Black, E, Black, H, Black, K, Black, M, Black, P, Black, S, Blackgrove, H, Blackledge, B, Blackler, J, Blackley, S, Blackman, H, Blackstock, C, Blair, C, Blakemore, F, Blamey, H, Bland, A, Blane, S, Blankley, S, Blaxill, P, Blaylock, K, Blazeby, J, Blencowe, N, Bloom, B, Bloomfield, J, Bloss, A, Blowers, A, Blows, S, Bloxham, H, Blundell, L, Blunsum, A, Blunt, M, Blunt, T, Blyth, I, Blyth, K, Blythe, A, Blythe, K, Boampoaa, M, Board, S, Bobie, B, Bobruk, K, Bodalia, P, Bodasing, N, Boden, M, Bodenham, T, Boehmer, G, Boffito, M, Bohanan, K, Bohmov, K, Bohnacker, N, Bokhandi, S, Bokhar, M, Bokhari, S, Bokobza, I, Boles, A, Bolger, C, Bond, C, Bond, H, Bond, S, Bond, T, Bone, A, Boniface, G, Bonney, L, Booker, L, Boot, S, Boothroyd, M, Borbone, J, Borman, N, Bosence, S, Bostock, K, Botting, N, Bottrill, F, 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Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2024
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9. VTXO: The Virtual Telescope for X-ray Observations
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Krizmanic, John F., Shah, Neerav, Calhoun, Philip C., Harding, Alice K., Purves, Lloyd R., Webster, Cassandra M., Corcoran, Michael F., Shrader, Chris R., Stochaj, Steven J., Rankin, Kyle A., Smith, Daniel T., Park, Hyeongjun, Boucheron, Laura E., Kota, Krishna, and Naseri, Asal
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Virtual Telescope for X-ray Observations (VTXO) will use lightweight Phase Fresnel Lenses (PFLs) in a virtual X-ray telescope with $\sim$1 km focal length and with $\sim$50 milli-arcsecond angular resolution. VTXO is formed by using precision formation flying of two SmallSats: a smaller OpticsSat that houses the PFLs and navigation beacons while a larger DetectorSat contains an X-ray camera, a precision start tracker, and the propulsion for the formation flying. The baseline flight dynamics uses a highly elliptical supersynchronous orbit allow the formation to hold in an inertial frame around the 90,000 km apogee for 10 hours of the 32.5 hour orbit with nearly a year mission lifetime. VTXO's fine angular resolution enables measuring the environments close to the central engines of bright compact X-ray sources. This X-ray imaging capability allows for the study of the effects of dust scattering near to the central objects such as Cyg X-3 and GX 5-1, for the search for jet structure near to the compact object in X-ray novae such as Cyg X-1 and GRS 1915+105, and for the search for structure in the termination shock of in the Crab pulsar wind nebula. The VTXO SmallSat and instrument designs, mission parameters, and science performance are described. VTXO development was supported as one of the selected 2018 NASA Astrophysics SmallSat Study (AS$^3$) missions., Comment: 6 pages, 7 figures, corrected version, Proceedings Volume 11444, Space Telescopes and Instrumentation 2020: Ultraviolet to Gamma Ray; 114447V (2020). arXiv admin note: text overlap with arXiv:2006.12174
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- 2020
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10. Deformation strengthening of uranium and dilute uranium alloys
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Eckelmeyer, Kenneth H., Dudder, Gordon B., Chapman, Lloyd R., Ludtka, Gerard M., and O'Brien, Mary K.
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- 2024
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11. Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1
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Minko, Irina G., Moellmer, Samantha A., Luzadder, Michael M., Tomar, Rachana, Stone, Michael P., McCullough, Amanda K., and Stephen Lloyd, R.
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- 2024
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12. Optical design for CETUS: a wide-field 1.5m aperture UV payload being studied for a NASA probe class mission study
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Woodruff, Robert A., Danchi, William C., Heap, Sara R., Hull, Tony, Kendrick, Stephen E., Purvesb, Lloyd R., Rhee, Michael S., Mentzell, Eric, Fleming, Brian, Valente, Marty, Burge, James, Lewis, Ben, Dodson, Kelly, Mehle, Greg, and Tomic, Matt
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
As part of a study funded by NASA Headquarters, we are developing a Probe-class mission concept called the Cosmic Evolution Through UV Spectroscopy (CETUS). CETUS includes a 1.5-m aperture diameter telescope with a large field-of-view (FOV). CETUS includes three scientific instruments: a Far Ultraviolet (FUV) and Near Ultraviolet (NUV) imaging camera (CAM); a NUV Multi-Object Spectrograph (MOS); and a dual-channel Point Source Spectrograph (PSS) in the Lyman Ultraviolet (LUV), FUV, and NUV spectral regions. The large FOV Three Mirror Anastigmatic (TMA) Optical Telescope Assembly (OTA) simultaneously feeds the three separate scientific instruments. That is, the instruments view separate portions of the TMA image plane, enabling parallel operation of the three instruments. The field viewed by the MOS, whose design is based on an Offner-type spectrographic configuration to provide wide FOV correction, is actively configured to select and isolate numerous field sources using a next-generation Micro-Shutter Array (MSA). The two-channel camera design is also based on an Offner-like configuration. The Point Source Spectrograph (PSS) performs high spectral resolution spectroscopy on unresolved objects over the NUV region with spectral resolving power, R~ 40,000, in an echelle mode. The PSS also performs long-slit imaging spectroscopy at R~ 20,000 in the LUV and FUV spectral regions with two aberration-corrected, blazed, holographic gratings used in a Rowland-like configuration. The optical system also includes two Fine Guidance Sensors (FGS), and Wavefront Sensors (WFS) that sample numerous locations over the full OTA FOV. In-flight wavelength calibration is performed by a Wavelength Calibration System (WCS), and flat-fielding is also performed, both using in-flight calibration sources. This paper will describe the current optical design and the major trade studies leading to the design.
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- 2019
13. Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Abidin, A, Aboaba, A, Aboagye-Odei, A, Aboah, C, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, HJ, Abu-Arafeh, A, Abubacker, SM, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, F, Acheampong, P, Acheampong, S, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, AS, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adatia, K, Adcock, K, Addai-Boampong, L, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, FW, Adesemoye, OA, Adewunmi, EO, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikari, B, Adhikari, SA, Adhikary, R, Aditya, A, Adjepong, P, Adkins, G, Adnan, A, Adriaanse, M, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Afrim, P, Afriyie, FA, Aftab, ZA, Afum-Adjei Awuah, A, Agarwal, M, Agasiya, PN, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Agyekum, JA, Agyen, K, Ahadome, EK, Ahamed Sadiq, S, Ahammed Nazeer, MH, Ahmad, M, Ahmad, S, Ahmed, A, Ahmed, BAR, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmed, M, Ahmed, MC, Ahmed, MS, Ahmed, N, Ahmed, O, Ahmed, RA, Ahmed, R, Ahmed, S, Ahmed, SG, Ahmed, SH, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aidoo, C, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, 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Vancheeswaran, R, Vandeyoon, SI, Vankayalapati, P, Vanmali, P, Vansomeren, C, Van't Hoff, W, Vanya, KN, Vara, S, Vardy, SJ, Varghese, A, Varghese, M, Varney, W, Varnier, G, Varouxaki, A-N, Varquez, R, Vasadi, V, Vass, O, Vassell, K, Vasu, V, Vasudevan, V, Vatish, M, Vaughan, S, Vayalaman, H, Vayapooree, D, Vaz, C, Veale, N, Veerasamy, S, Velankar, S, Velauthar, L, Veli, N, Vella, N, Velugupati, A, Velusamy, A, Venables, I, Venditti, M, Venkataramakrishnan, R, Venn, R, Venter, M, Ventilacion, L, Vere, J, Veres, M, Vergnano, S, Verling, W, Verma, A, Vernall, R, Vernon, B, Vertue, M, Verueco, L, Verula, J, Veterini, A, Vethanayagam, N, Vettikumaran, S, Veys, L, Vickers, C, Victor, S, Victoria, S, Vidaillac, CP, Vidler, J, Vijayakumar, B, Vijayaraghavan Nalini, VW, Vilcinskaite, B, Vileito, A, Vilimiene, N, Vinall, L, Vinay, S, Vinayakarao, L, Vincent, O, Vincent, R, Virdee, P, Virgilio, E, Virk, AM, Visentin, E, Vitaglione, M, Vithian, K, Vittoria, S, Vivekananthan, S, Vlad, E, Vlies, B, von Oven, L, Vooght, C, Vu Thai, KT, Vutipongsatorn, K, Vuylsteke, A, Vyras, E, Wach, R, Wadams, B, Wadd, S, Waddington, N, Wade, P, Wadsley, J, Wadsworth, K, Wafa, SEI, Wagstaff, D, Wagstaff, L, Wahab, D, Wahbi, Z, Waheed Adigun, A, Waidyanatha, S, Waite, A, Wake, R, Wakefield, A, Wakeford, W, Wakinshaw, F, Waldeck, E, Walden, A, Walding, L, Waldron, A, Waldron, J, Wales, E, Wali, B, Walker, D, Walker, G, Walker, H, Walker, I, Walker, K, Walker, L, Walker, O, Walker, R, Walker, S, Wallace, G, Wallbutton, R, Wallen, J, Wallendszus, K, Waller, A, Waller, R, Wallis, G, Wallis, L, Wallis, M, Walmsley, E, Walsh, D, Walsh, E, Walsh, L, Walstow, D, Walter, D, Walters, A, Walters, H, Walters, J, Walton, E, Walton, L, Walton, M, Walton, O, Walton, S, Wan, M, Wanda, J, Wands, M, Wane, R, Wang, F, Wang, N, Wang, R, Wang, S, Warbrick, D, Warburton, S, Ward, C, Ward, D, Ward, E, Ward, H, Ward, J, Ward, L, Ward, N, Ward, R, Ward, T, Warden, SA, Wardere, G, Wardle, S, Wardy, H, Waring, G, Waring, S, Warmington, J, Warner, B, Warner, C, Warnock, L, Warran, S, Warren, J, Warren, L, Warren, R, Warren, Y, Warrender, D, Warren-Miell, H, Warris, A, Warwick, G, Wassall, H, Wasserman, S, Wasson, E, Watchorn, HJ, Waterfall, H, Waters, A, Waters, D, Waterstone, M, Watkin, A, Watkins, C, Watkins, E, Watkins, K, Watkins, L, Watson, A, Watson, AJR, Watson, E, Watson, F, Watson, JGR, Watson, L, Watson, P, Watson, R, Watson, K, Watters, M, Watterson, D, Wattimena, K, Watts, D, Watts, J, Watts, M, Waugh, V, Wayman, E, Wayman, M, Wazir, A, Weatherhead, M, Weatherly, N, Webb, C, Webb, H, Webb, K, Webb, S, Websdale, C, Webster, D, Webster, I, Webster, J, Webster, T, Wedlin, J, Wee, L, Weerakoon, R, Weerasinghe, T, Weeratunga, J, Weetman, M, Wei, S, Weichert, I, Welch, E, Welch, H, Welch, J, Welch, L, Welch, S, Welham, B, Weller, S, Wellings, L, Wells, B, Wellstead, S, Welsh, B, Welsh, R, Welters, I, Welton, R, Wenn, V, Wentworth, L, Wesonga, J, Wesseldine, K, West, J, West, M, West, R, West, S, Western, L, Westhead, R, Weston, H, Westwood, A, Westwood, K, Westwood, S, Wetherill, B, Wheaver, S, Wheeler, H, Whelan, B, Whelband, M, Whileman, A, Whitcher, A, White, A, White, B, White, C, White, D, White, J, White, K, White, M, White, N, White, S, White, T, Whitehead, C, Whitehorn, K, Whitehouse, A, Whitehouse, C, Whitehouse, T, Whiteley, J, Whiteley, L, Whiteley, S, Whitham, R, Whitlingum, G, Whitmore, D, Whittaker, E, Whittam, L, Whittington, A, Whittle, H, Whittle, R, Wiafe, E, Wiblin, L, Wickens, O, Widdrington, J, Wieboldt, J, Wieringa, H, Wiesender, C, Wiffen, L, Wight, A, Wignall, A, Wignall, C, Wilce, A, Wilcock, D, Wilcock, E, Wilcox, L, Wild, B, Wild, L, Wild, S, Wilde, M, Wilding, L, Wilding, P, Wildsmith, T, Wileman, J, Wiles, J, Wiles, K, Wilhelmsen, E, Wiliams, T, Wilkie, J, Wilkin, D, Wilkins, H, Wilkins, J, Wilkins, S, Wilkinson, I, Wilkinson, L, Wilkinson, N, Wilkinson, S, Wilkinson, T, Willetts, S, Williams, A, Williams, C, Williams, CV, Williams, D, Williams, E, Williams, G, Williams, H, Williams, J, Williams, K, Williams, M, Williams, P, Williams, R, Williams, S, Williams, T, Williamson, A, Williamson, C, Williamson, D, Williamson, J, Williamson, JD, Williamson, R, Williamson, H, Willis, E, Willis, H, Willis, J, Wills, L, Willsher, L, Willshire, C, Willson, F, Willson, J, Wilson, A, Wilson, B, Wilson, D, Wilson, I, Wilson, J, Wilson, K, Wilson, K-A, Wilson, L, Wilson, M, Wilson, S, Wilson, T, Win, KLY, Win, M, Win, T, Win, TT, Win, WYW, Winckworth, L, Winder, L, Winder, P, Winearl, S, Winmill, H, Winn, S, Winpenny, C, Winslow, H, Winter, H, Winter, J, Winter-Goodwin, B, Winterton, J, Winwood, H, Wischhusen, J, Wisdom, S, Wise, M, Wiselka, M, Wiseman, R, Wiseman, S, Wishart, S, WIshlade, T, Witele, E, Withers, N, Wittes, J, Wixted, D, Wodehouse, T, Wolf, W, Wolff, N, Wolffsohn, K, Wolf-Roberts, R, Wolodimeroff, E, Wolstencroft, A, Wong, A, Wong, C, Wong, C-H, Wong, C-M, Wong, E, Wong, JSY, Wong, KY, Wong, MY, Wong, N, Wong, S, Wong, T, Wongkyezeng, AA, Wood, A, Wood, C, Wood, D, Wood, F, Wood, G, Wood, H, Wood, J, Wood, L, Wood, M, Wood, S, Wood, T, Woodall, K, Woodfield, R, Woodford, C, Woodford, E, Woodford, J, Woodhead, L, Woodhead, T, Woodland, P, Woodman, M, Woodmansey, S, Woods, C, Woods, J, Woods, K, Woods, S, Woodward, Z, Woolcock, M, Wooldridge, G, Woolf, R, Woollard, C, Woollen, L, Woolley, E, Woolley, J, Woosey, D, Wootton, D, Wootton, J, Worley, D, Worton, S, Wraight, J, Wray, M, Wren, K, Wren, L, Wrey Brown, C, Wright, C, Wright, D, Wright, F, Wright, H, Wright, I, Wright, L, Wright, R, Wright, S, Wright, T, Wroe, C, Wroe, H, Wu, H, Wu, P, Wubetu, J, Wulandari, F, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, BE, Xia, Z, Yacoba, E, Yadav, S, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, WL, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, T, Yates, M, Ye, J, Yearwood Martin, C, Yein, K, Yelnoorkar, F, Yen, LM, Yeoh, A, Yeung, CY, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yovita, H, Yu, C, Yuan, JSJ, Yufaniaputri, N, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-S, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zayed, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zhu, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, ET, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2023
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14. Addendum to: “The response of aquifers to periodic forcing”, 18(3), 125–146, 1995
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Townley, Lloyd R.
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- 2023
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15. Functional analyses of single nucleotide polymorphic variants of the DNA glycosylase NEIL1 in sub-Saharan African populations
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Zuckerman, Jamie T., Minko, Irina G., Kant, Melis, Jaruga, Pawel, Stone, Michael P., Dizdaroglu, Miral, McCullough, Amanda K., and Lloyd, R. Stephen
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- 2023
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16. Self-Perception of Transition Readiness Amongst Pediatric Patients with Childhood Heart Disease
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Sanker, Sean, Guarino, Kathleen, and Feit, Lloyd R.
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- 2022
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17. Implementation of a Psychiatry Capstone Course for Fourth Year Medical Students
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Ryznar, Elizabeth, Khandai, Abhisek, Taylor, Adrienne D., and Lloyd, R. Brett
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- 2022
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18. Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1
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Minko, Irina G, Vartanian, Vladimir L, Tozaki, Naoto N, Coskun, Erdem, Coskun, Sanem Hosbas, Jaruga, Pawel, Yeo, Jongchan, David, Sheila S, Stone, Michael P, Egli, Martin, Dizdaroglu, Miral, McCullough, Amanda K, and Lloyd, R Stephen
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Biochemistry and Cell Biology ,Biological Sciences ,Genetics ,Cancer ,Adenosine Deaminase ,Amino Acid Substitution ,Catalytic Domain ,DNA Adducts ,DNA Glycosylases ,Gas Chromatography-Mass Spectrometry ,Gene Editing ,Humans ,Models ,Molecular ,Molecular Weight ,Protein Conformation ,RNA-Binding Proteins ,Substrate Specificity ,Base excision repair ,RNA editing ,Formamidopyrimidines ,Thymine glycol ,Aflatoxin ,Hepatocellular carcinoma ,Developmental Biology ,Biochemistry and cell biology - Abstract
Pre-mRNA encoding human NEIL1 undergoes editing by adenosine deaminase ADAR1 that converts a single adenosine to inosine, and this conversion results in an amino acid change of lysine 242 to arginine. Previous investigations of the catalytic efficiencies of the two forms of the enzyme revealed differential release of thymine glycol (ThyGly) from synthetic oligodeoxynucleotides, with the unedited form, NEIL1 K242 being ≈30-fold more efficient than the edited NEIL1 K242R. In contrast, when these enzymes were reacted with oligodeoxynucleotides containing guanidinohydantoin or spiroiminohydantoin, the edited K242R form was ≈3-fold more efficient than the unedited NEIL1. However, no prior studies have investigated the efficiencies of these two forms of NEIL1 on either high-molecular weight DNA containing multiple oxidatively-induced base damages, or oligodeoxynucleotides containing a bulky alkylated formamidopyrimidine. To understand the extent of changes in substrate recognition, γ-irradiated calf thymus DNA was treated with either edited or unedited NEIL1 and the released DNA base lesions analyzed by gas chromatography-tandem mass spectrometry. Of all the measured DNA lesions, imidazole ring-opened 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) were preferentially released by both NEIL1 enzymes with K242R being ≈1.3 and 1.2-fold more efficient than K242 on excision of FapyAde and FapyGua, respectively. Consistent with the prior literature, large differences (≈7.5 to 12-fold) were measured in the excision of ThyGly from genomic DNA by the unedited versus edited NEIL1. In contrast, the edited NEIL1 was more efficient (≈3 to 5-fold) on release of 5-hydroxycytosine. Excision kinetics on DNA containing a site-specific aflatoxin B1-FapyGua adduct revealed an ≈1.4-fold higher rate by the unedited NEIL1. Molecular modeling provides insight into these differential substrate specificities. The results of this study and in particular, the comparison of substrate specificities of unedited and edited NEIL1 using biologically and clinically important base lesions, are critical for defining its role in preservation of genomic integrity.
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- 2020
19. Method development in liquid chromatography
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Dolan, John W., primary and Snyder, Lloyd R., additional
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- 2023
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20. Liquid–solid chromatography
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Snyder, Lloyd R., primary and Dolan, John W., additional
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- 2023
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21. Milestones in the development of liquid chromatography
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Snyder, Lloyd R., primary and Dolan, John W., additional
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- 2023
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22. Psyche Mission’s End-to-End Information System Architecture: Advantages, Challenges, and Operability
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Sirohi, Richa, Moore, Robert R., Deforrest, Lloyd R., Thornton, Marla S., Larson, Kristina L., Wenkert, Daniel D., Kazz, Greg J., De Rosa, Sergio, Series Editor, Zheng, Yao, Series Editor, Popova, Elena, Series Editor, Cruzen, Craig, editor, Schmidhuber, Michael, editor, and Lee, Young H., editor
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- 2022
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23. Electron Microscopy and Elemental Analysis of Defective Drysdale Nucleus Manipulator Instruments Implicated in Surgical Complications
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Kopecny, Lloyd R., Biazik, Joanna M., and Coroneo, Minas T.
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- 2023
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24. Reproduction and Dispersal of Biological Soil Crust Organisms
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Warren, Steven D, Clair, Larry L, Stark, Lloyd R, Lewis, Louise A, Pombubpa, Nuttapon, Kurbessoian, Tania, Stajich, Jason E, and Aanderud, Zachary T
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Microbiology ,Biological Sciences ,Ecology ,Life on Land ,biological soil crusts ,bacteria ,fungi ,terrestrial algae ,bryophytes ,reproduction ,aerial dispersal ,Evolutionary Biology ,Evolutionary biology ,Ecological applications - Abstract
Biological soil crusts (BSCs) consist of a diverse and highly integrated community of organisms that effectively colonize and collectively stabilize soil surfaces. BSCs vary in terms of soil chemistry and texture as well as the environmental parameters that combine to support unique combinations of organisms—including cyanobacteria dominated, lichen-dominated, and bryophyte-dominated crusts. The list of organismal groups that make up BSC communities in various and unique combinations include—free living, lichenized, and mycorrhizal fungi, chemoheterotrophic bacteria, cyanobacteria, diazotrophic bacteria and archaea, eukaryotic algae, and bryophytes. The various BSC organismal groups demonstrate several common characteristics including—desiccation and extreme temperature tolerance, production of various soil binding chemistries, a near exclusive dependency on asexual reproduction, a pattern of aerial dispersal over impressive distances, and a universal vulnerability to a wide range of human-related perturbations. With this publication, we provide literature-based insights as to how each organismal group contributes to the formation and maintenance of the structural and functional attributes of BSCs, how they reproduce, and how they are dispersed. We also emphasize the importance of effective application of molecular and microenvironment sampling and assessment tools in order to provide cogent and essential answers that will allow scientists and land managers to better understand and manage the biodiversity and functional relationships of soil crust communities.
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- 2019
25. The transition of WRRF models to digital twin applications
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Elena Torfs, Niels Nicolaï, Saba Daneshgar, John B. Copp, Henri Haimi, David Ikumi, Bruce Johnson, Benedek B. Plosz, Spencer Snowling, Lloyd R. Townley, Borja Valverde-Pérez, Peter A. Vanrolleghem, Luca Vezzaro, and Ingmar Nopens
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data management ,hybrid models ,interoperability ,model predictive control ,online optimisation ,proactive management ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
Digital Twins (DTs) are on the rise as innovative, powerful technologies to harness the power of digitalisation in the WRRF sector. The lack of consensus and understanding when it comes to the definition, perceived benefits and technological needs of DTs is hampering their widespread development and application. Transitioning from traditional WRRF modelling practice into DT applications raises a number of important questions: When is a model's predictive power acceptable for a DT? Which modelling frameworks are most suited for DT applications? Which data structures are needed to efficiently feed data to a DT? How do we keep the DT up to date and relevant? Who will be the main users of DTs and how to get them involved? How do DTs push the water sector to evolve? This paper provides an overview of the state-of-the-art, challenges, good practices, development needs and transformative capacity of DTs for WRRF applications. HIGHLIGHTS A Digital Twin distinguishes itself from a simulation model by a continuous, automated data connection.; Current DT projects in WRRFs focus on operational support and control.; Combining mechanistic models and data-driven techniques into hybrid models can accelerate the adoption of DTs.; Data and information models are key for the implementation and upscaling of DTs.; WRRF staff should be included during the development stages of DTs.;
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- 2022
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26. Enhanced cytarabine-induced killing in OGG1-deficient acute myeloid leukemia cells
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Owen, Nichole, Minko, Irina G., Moellmer, Samantha A., Cammann, Sydney K., Lloyd, R. Stephen, and McCullough, Amanda K.
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- 2021
27. The effect of Ti content on age hardening and mechanical properties of uranium-titanium alloys
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Eckelmeyer, Kenneth H., Romig, A.D., Jr., Ludtka, Gerard M., Mackiewicz-Ludtka, Gail, and Chapman, Lloyd R.
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- 2022
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28. Longevity records for desiccated shoots and spores of desert bryophytes.
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Stark, Lloyd R. and dos Santos, Wagner Luiz
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HUMIDITY , *SPORES , *LONGEVITY , *ALTITUDES , *DESERTS - Abstract
Collections of 36 species of predominantly low elevation Mojave Desert bryophytes from the mid-1990s were assessed for shoot and spore viability. Adult shoots of 16 (of 36) and spores of 14 (of 25) desert species were capable of germination or regeneration after 28 years of continuous desiccation (dark storage) under conditions of ∼23°C and 25–45% relative humidity. Most of the species found viable were in the families Pottiaceae and Grimmiaceae, but also included species of Bryum, Funaria and Ptychostomum. Both shoots and spores from the same collection (patch) of 9 species were viable, including Funaria hygrometrica, regarded in other habitats as an annual species. The oldest collection found viable was from shoots of Grimmia anodon, 29 yr 3 mos. Based on the vigor of shoot and spore regeneration/ germination observed in several species, the records presented here for desiccation longevity should be exceeded in the future. [ABSTRACT FROM AUTHOR]
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- 2024
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29. Germination Trials in Newly Reported Tubers of Timmiella crassinervis.
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Russell, Alexander, Clark, Theresa A., Greenwood, Joshua L., dos Santos, Wagner Luiz, Pietrasiak, Nicole, and Stark, Lloyd R.
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ASEXUAL reproduction ,RHIZOIDS ,BIOMASS ,GERMINATION ,FIBERS - Abstract
Tubers are described for the first time in the moss genus Timmiella (Pottiaceae). Using uniclonal cultures, tubers were produced after at least 3 months, were spherical, often occurred in groups ("nests"), ranged in size from 10–600 µm in diameter, and had a water content of ∼4% (dry wt basis) while yet retaining an oil-like residue. On a per individual shoot basis, belowground biomass in cultures equaled aboveground biomass. Tubers germinated in ∼3 days from planting by producing multiple protonemal filaments, similar to detached shoot tips and rhizoids, but much more rapidly than detached leaves. Germinated tubers eventually formed a colony (producing 50 protonemal shoots and extending horizontally 11 mm) in ∼30 days, measures very similar to detached shoot tips, and faster than rhizoids and detached leaves. The presence of Timmiella crassinervis in frequently burned regions of chaparral suggests fire frequency in California may have selected for greater belowground allocation. [ABSTRACT FROM AUTHOR]
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- 2024
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30. The effects of Ti content and quenching on phase transformations, microstructures, and mechanical properties in uranium-titanium alloys
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Eckelmeyer, Kenneth H., Romig, A.D., Jr., Ludtka, Gerard M., Mackiewicz-Ludtka, Gail, and Chapman, Lloyd R.
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- 2022
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31. Mass Spectrometry-Based Method to Measure Aflatoxin B1 DNA Adducts in Formalin-Fixed Paraffin-Embedded Tissues
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Bellamri, Medjda, primary, Yao, Lihua, additional, Tomar, Rachana, additional, Vartanian, Vladimir, additional, Rizzo, Carmelo J., additional, Stone, Michael P., additional, Groopman, John D., additional, Lloyd, R. Stephen, additional, and Turesky, Robert J., additional
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- 2024
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32. Using the Double Ring Test to Assess the Effect of Type of Aggregate Used on Thermal Cracking Potential of Concrete
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Chilwesa, M., Akbarnezhad, A., Gharehchaei, M., Castel, A., Lloyd, R., Foster, S., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Ho, Johnny C.M., editor, and Kitipornchai, Sritawat, editor
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- 2020
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33. DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model
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Paluri, Sesha L., Burak, Matthew, Senejani, Alireza G., Levinson, Madison, Rahim, Tania, Clairmont, Kaylyn, Kashgarian, Michael, Alvarado-Cruz, Isabel, Meas, Rithy, Cardó-Vila, Marina, Zeiss, Caroline, Maher, Stephen, Bothwell, Alfred L.M., Coskun, Erdem, Kant, Melis, Jaruga, Pawel, Dizdaroglu, Miral, Stephen Lloyd, R., and Sweasy, Joann B.
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- 2021
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34. The Effect of a Mindfulness Induction on Coping Strategy Preferences across Stressor Types among African Americans
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Womack, Veronica Y., primary and Sloan, Lloyd R., additional
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- 2022
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35. Psyche Mission’s End-to-End Information System Architecture: Advantages, Challenges, and Operability
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Sirohi, Richa, primary, Moore, Robert R., additional, Deforrest, Lloyd R., additional, Thornton, Marla S., additional, Larson, Kristina L., additional, Wenkert, Daniel D., additional, and Kazz, Greg J., additional
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- 2022
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36. Characterization of crude oils derived from carbonate and siliciclastic source rocks using FTICR-MS
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Hossein Hosseini, S., Sachsenhofer, Reinhard F., Snowdon, Lloyd R., and Oldenburg, Thomas B.P.
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- 2021
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37. Understanding desiccation tolerance and sex-specific responses in Bryum argenteum: insights from phenological phases and physiological analyses.
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Santos, Wagner Luiz dos, Medina-Ramos, Andrea, Greenwood, Joshua, Pôrto, Kátia Cavalcanti, Pinheiro, Fábio, and Stark, Lloyd R
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TROPICAL dry forests ,PLANT phenology ,PHOTOSYSTEMS ,QUANTUM efficiency ,REPRODUCTION ,WATER shortages ,PLANT shoots - Abstract
Background and Aims Desiccation tolerance (DT) is crucial for survival in arid environments, where organisms develop strategies in reproduction, maintenance and defence to cope with water scarcity. Therefore, investigating the relationship between reproduction and DT is essential to understand the ecology and adaptive strategies of species. This study explores the connection between the development of male and female gametangia in the moss Bryum argenteum and the decrease in DT during the progression of phenological phases in gametangia and protonema. Methods Samples collected from a dry tropical forest in Brazil were cultivated, cloned and subjected to desiccation. Subsequently, the physiological parameters of shoots and protonemata were analysed. Shoot and protonema regeneration were monitored for 28 d after the physiological analyses. Both phases were subjected to control and desiccation treatments. Key Results Significant effects of desiccation and sex on the physiological parameters and regeneration capacity of shoots and protonemata were found. Male shoots generally exhibited lower values of Fv/Fm (quantum efficiency of photosystem II) and ϕPSII (effective quantum yield of photosystem II), while females demonstrated higher values and better recovery after desiccation. Protonemata also showed variation in Fv/Fm over time and with sex, with no significant differences in ϕPSII between them. Desiccated male shoots had higher mortality rates and produced fewer new shoots. For females, the regeneration patterns varied between the desiccation-exposed groups and the control, with decreased shoot production, and some protonemata growing into filaments without forming shoots. Conclusion These findings improve our understanding of the ecological responses of bryophytes to desiccation stress and provide insights into their adaptive strategies in challenging environments, such as the possible rarity of males in dioicous moss populations. [ABSTRACT FROM AUTHOR]
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- 2024
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38. Genotypic confirmation of a biased phenotypic sex ratio in a dryland moss using restriction fragment length polymorphisms
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Jenna T. B. Ekwealor, Simone D. Benjamin, Jordan Z. Jomsky, Matthew A. Bowker, Lloyd R. Stark, D. Nicholas McLetchie, Brent D. Mishler, and Kirsten M. Fisher
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bryophyte ,desert ,dryland ,restriction fragment length polymorphism (RFLP) ,sex chromosome ,sex ratio ,Biology (General) ,QH301-705.5 ,Botany ,QK1-989 - Abstract
Abstract Premise In dioicous mosses, sex is determined by a single U (female, ♀) or V (male, ♂) chromosome. Although a 1 : 1 sex ratio is expected following meiosis, phenotypic sex ratios based on the production of gametangia are often female‐biased. The dryland moss Syntrichia caninervis (Pottiaceae) is notable for its low frequency of sex expression and strong phenotypic female bias. Here we present a technique to determine genotypic sex in a single shoot of S. caninervis, and report results of a case study examining genotypic and phenotypic sex ratios. Methods We reanalyzed 271 non‐expressing gametophyte shoots from a previous study on S. caninervis sex expression across microhabitats using a restriction fragment length polymorphism (RFLP) method. Results We recovered a genotypic sex ratio in non‐expressing shoots of 18.4♀ : 1♂, which exceeds the female bias of the phenotypic ratio (5.3♀ : 1♂; P = 0.013). We also found that the distribution of male and female genotypes across microsites with different levels of sun exposure was not predicted by patterns of sex expression in these microsites. Discussion These findings contribute to our understanding of how the environment may modulate sex ratios in S. caninervis, either through its direct influence on sex expression or through selection on genotypes with particular sex expression phenotypes.
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- 2022
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39. Temporal arteritis: Neurological and ophthalmological involvement in the absence of documented systemic features
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Chan, Jian S., primary, Dimitrovski, Dimitria, additional, Huang, William, additional, Yang, Geraldine, additional, Tweedie, Peter J., additional, Kopecny, Lloyd R., additional, Tipirneni, Shraddha, additional, Borchert, Grace A., additional, Ouyang, Catherine M.H., additional, Tsoi, Amy T.W., additional, Vasanthan, Aadhavi, additional, Rezkalla, Mina, additional, Lee, Natalie S., additional, Gunasegaram, James R., additional, Fatima, Aleeza, additional, Allende, Alexandra, additional, Meades, Kerrie V., additional, Gaden, Susan C., additional, FRANZCO, Ashish Agar, additional, and FRACS FRANZCO, Ian C. Francis, additional
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- 2024
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40. Pain and Urinary Symptoms Should Not be Combined into a Single Score: Psychometric Findings from the MAPP Research Network
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Griffith, James W, Stephens-Shields, Alisa J, Hou, Xiaoling, Naliboff, Bruce D, Pontari, Michel, Edwards, Todd C, Williams, David A, Clemens, J Quentin, Afari, Niloofar, Tu, Frank, Lloyd, R Brett, Patrick, Donald L, Mullins, Chris, Kusek, John W, Sutcliffe, Siobhan, Hong, Barry A, Lai, H Henry, Krieger, John N, Bradley, Catherine S, Kim, Jayoung, and Landis, J Richard
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Biomedical and Clinical Sciences ,Clinical Sciences ,Neurosciences ,Interstitial Cystitis ,Urologic Diseases ,Pain Research ,Clinical Research ,Chronic Pain ,Renal and urogenital ,Adult ,Aged ,Aged ,80 and over ,Biomedical Research ,Cystitis ,Interstitial ,Depression ,Female ,Humans ,Male ,Middle Aged ,Pain Measurement ,Patient Care Team ,Pelvic Pain ,Psychometrics ,Surveys and Questionnaires ,Symptom Assessment ,Young Adult ,urinary bladder ,prostatitis ,cystitis ,interstitial ,chronic pain ,factor analysis ,statistical - Abstract
PurposeThe purpose of this study was to create symptom indexes, that is scores derived from questionnaires to accurately and efficiently measure symptoms of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, collectively referred to as urological chronic pelvic pain syndromes. We created these indexes empirically by investigating the structure of symptoms using exploratory factor analysis.Materials and methodsAs part of the MAPP (Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain) Research Network 424 participants completed questionnaires, including GUPI (Genitourinary Pain Index), ICSI (Interstitial Cystitis Symptom Index) and ICPI (Interstitial Cystitis Problem Index). Individual items from questionnaires about bladder and pain symptoms were evaluated by principal component and exploratory factor analyses to identify indexes with fewer questions to comprehensively quantify symptom severity. Additional analyses included correlating symptom indexes with symptoms of depression, which is a known comorbidity of patients with pelvic pain.Results and conclusionsExploratory factor analyses suggested that the 2 factors pain severity and urinary severity provided the best psychometric description of items in GUPI, ICSI and ICPI. These factors were used to create 2 symptom indexes for pain and urinary symptoms. Pain, but not urinary symptoms, was associated with symptoms of depression on multiple regression analysis, suggesting that these symptoms may impact patients with urological chronic pelvic pain syndromes differently (B ± SE for pain severity = 0.24 ± 0.04, 95% CI 0.16-0.32, β = 0.32, p
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- 2016
41. Understanding Assessment Systems for Clinical Competency Committee Decisions: Evidence from a Multisite Study of Psychiatry Residency Training Programs
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Lloyd, R. Brett, Park, Yoon Soo, Tekian, Ara, and Marvin, Robert
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- 2020
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42. Rate of drying influences tolerance of low water contents in the moss Funaria hygrometrica (Funariaceae)
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McLetchie, D. Nicholas and Stark, Lloyd R.
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- 2019
43. Contributions Toward a Bryoflora of Nevada: Bryophytes New for the Silver State. Part III
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Brinda, John C, Stark, Lloyd R, Shevock, James R, Spence, John R, and BioStor
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- 2014
44. Pilot Study of an Online Self-Directed Learning Module for Medical Decision-Making Capacity
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Ryznar, Elizabeth, Hamaoka, Derrick, and Lloyd, R. Brett
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- 2020
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45. System integration studies for modern electrified railways
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CORE (2018 : Sydney, NSW), Bagnall, Trevor M, Flinders, Frank M, Nicholson, Stephen V, and Major, Lloyd R
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- 2018
46. The dating of petroleum fluid residence time in subsurface reservoirs. Part 1: A radiolysis-based geochemical toolbox
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Larter, Steve, Silva, Renzo C., Marcano, Norka, Snowdon, Lloyd R., Villarreal-Barajas, J. Eduardo, Sonei, Roshanak, Paredes Gutiérrez, Lydia C., Huang, Haiping, Stopford, Andrew, Oldenburg, Thomas B.P., Zhao, Jing, Weerawardhena, Priyanthi, Nightingale, Michael, Mayer, Bernhard, Pedersen, Jon H., and di Primio, Rolando
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- 2019
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47. An observation of male-male combat in Gwardars or Western Brown Snakes (Pseudonaja mengdeni) on Dirk Hartog Island, Western Australia
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Lloyd, R, Reinhold, L, and BioStor
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- 2013
48. Stakeholders' Forum on Integrated Flood Risk Management in Cagayan River Basin: Basis in Writing Policy Recommendations.
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Balderama, Orlando F., Raymundo, Jennelyn L., Alejo, Lanie A., Bareng, Jeoffrey Lloyd R., Bamabalan, Gwendolyn C., and Mangadap, Carol Joy F.
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STAKEHOLDERS ,WATER supply ,FLOOD risk ,GOVERNMENT agencies ,SEDIMENTATION & deposition - Abstract
The stakeholders' forum aimed to enhance the capacities of policymakers, managers, and practitioners of river basin organizations on flood management through knowledge sharing of new approaches, techniques, methodologies, and good practices from partners here and abroad to help achieve effective implementation of integrated flood risk management as a component of integrated water resources management. The study followed a qualitative research methodology; thus, observation and documentation of each series of planned activities, semi-structured and unstructured interviews with the executive leaders of national agencies and international partners, and discourse analysis of the shared presentations and knowledge exchange between or among the stakeholders were conducted to surface specific themes that described how this stakeholders' forum enhanced the implementation of integrated water resources management in the country through a multipartite communication platform. The research findings revealed that international and national partnership is fortified and R&D efforts will be rapidly realized through a multipartite information exchange, collaborative workshop, technology transfer, and other knowledge-sharing activities. Moreover, legal agreements entered by all stakeholders to scale up global and community linkages are a salient measure to encourage and motivate stakeholders to take part in the implementation of STI-based efforts stipulated in such legal documents. Joint field visits, series of fellowships, and use of websites for information dissemination also have pivotal roles in acquiring a profound understanding of dam situations in the Philippines and Japan, and how integrated water resources management will be communicated to various community partners. Thus, the forum served as a channel that bridged what the government agencies and organizations know about flood and sedimentation management and what the community partners need to understand to revitalize science-community-government-academe collaboration. [ABSTRACT FROM AUTHOR]
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- 2024
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49. Mass Spectrometry-Based Method to Measure Aflatoxin B1 DNA Adducts in Formalin-Fixed Paraffin-Embedded Tissues.
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Bellamri, Medjda, Yao, Lihua, Tomar, Rachana, Vartanian, Vladimir, Rizzo, Carmelo J., Stone, Michael P., Groopman, John D., Lloyd, R. Stephen, and Turesky, Robert J.
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- 2024
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50. The aflatoxin B1‐induced imidazole ring‐opened guanine adduct: High mutagenic potential that is minimally affected by sequence context.
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Minko, Irina G., Kellum, Andrew H., Stone, Michael P., and Lloyd, R. Stephen
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MUTAGENS ,DNA adducts ,GUANINE ,IMIDAZOLES ,DNA damage ,AFLATOXINS ,HEPATOCELLULAR carcinoma - Abstract
Dietary exposure to aflatoxin B1 (AFB1) is a recognized risk factor for developing hepatocellular carcinoma. The mutational signature of AFB1 is characterized by high‐frequency base substitutions, predominantly G>T transversions, in a limited subset of trinucleotide sequences. The 8,9‐dihydro‐8‐(2,6‐diamino‐4‐oxo‐3,4‐dihydropyrimid‐5‐yl‐formamido)‐9‐hydroxyaflatoxin B1 (AFB1‐FapyGua) has been implicated as the primary DNA lesion responsible for AFB1‐induced mutations. This study evaluated the mutagenic potential of AFB1‐FapyGua in four sequence contexts, including hot‐ and cold‐spot sequences as apparent in the mutational signature. Vectors containing site‐specific AFB1‐FapyGua lesions were replicated in primate cells and the products of replication were isolated and sequenced. Consistent with the role of AFB1‐FapyGua in AFB1‐induced mutagenesis, AFB1‐FapyGua was highly mutagenic in all four sequence contexts, causing G>T transversions and other base substitutions at frequencies of ~80%–90%. These data suggest that the unique mutational signature of AFB1 is not explained by sequence‐dependent fidelity of replication past AFB1‐FapyGua lesions. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
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