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14 results on '"Llopis‐Hernandez, Virginia"'

1. ABE8e adenine base editor precisely and efficiently corrects a recurrent COL7A1 nonsense mutation

Author

Sheriff, Adam, Guri, Ina, Zebrowska, Paulina, Llopis-Hernandez, Virginia, Brooks, Imogen R., Tekkela, Stavroula, Subramaniam, Kavita, Gebrezgabher, Ruta, Naso, Gaetano, Petrova, Anastasia, Balon, Katarzyna, Onoufriadis, Alexandros, Kujawa, Dorota, Kotulska, Martyna, Newby, Gregory, Łaczmański, Łukasz, Liu, David R., McGrath, John A., and Jacków, Joanna

Published
2022
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5. Review of emerging nanotechnology in bone regeneration: progress, challenges, and perspectives

Author

Hajiali, Hadi, Ouyang, Liliang, Llopis-Hernandez, Virginia, Dobre, Oana, and Rose, Felicity R. A. J.

Abstract

The application of nanotechnology to regenerative medicine has increased over recent decades. The development of materials that can influence biology at the nanoscale has gained interest as our understanding of the interactions between cells and biomaterials at the nanoscale has grown. Materials that are either nanostructured or influence the nanostructure of the cellular microenvironment have been developed and shown to have advantages over their microscale counterparts. There are several reviews which have been published that discuss how nanomaterials have been used in regenerative medicine, particularly in bone regeneration. Most of these studies have explored this concept in specific areas, such as the application of glass-based nanocomposites, nanotechnology for targeted drug delivery to stimulate bone repair, and the progress in nanotechnology for the treatment of osteoporosis. In this review paper, the impact of nanotechnology in biomaterials development for bone regeneration will be discussed highlighting specifically, nanostructured materials that influence mechanical properties, biocompatibility, and osteoinductivity.

Published
2021

6. Hydrogel Platforms: A Hydrogel Platform that Incorporates Laminin Isoforms for Efficient Presentation of Growth Factors – Neural Growth and Osteogenesis (Adv. Funct. Mater. 21/2021)

Author

Dobre, Oana, primary, Oliva, Mariana A. G., additional, Ciccone, Giuseppe, additional, Trujillo, Sara, additional, Rodrigo‐Navarro, Aleixandre, additional, Venters, Douglas Cormac, additional, Llopis‐Hernandez, Virginia, additional, Vassalli, Massimo, additional, Gonzalez‐Garcia, Cristina, additional, Dalby, Matthew J., additional, and Salmeron‐Sanchez, Manuel, additional

Published
2021
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7. A Hydrogel Platform that Incorporates Laminin Isoforms for Efficient Presentation of Growth Factors – Neural Growth and Osteogenesis

Author

Dobre, Oana, primary, Oliva, Mariana A. G., additional, Ciccone, Giuseppe, additional, Trujillo, Sara, additional, Rodrigo‐Navarro, Aleixandre, additional, Venters, Douglas Cormac, additional, Llopis‐Hernandez, Virginia, additional, Vassalli, Massimo, additional, Gonzalez‐Garcia, Cristina, additional, Dalby, Matthew J., additional, and Salmeron‐Sanchez, Manuel, additional

Published
2021
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8. The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

Author

Hodgkinson, Tom, primary, Tsimbouri, P. Monica, additional, Llopis-Hernandez, Virginia, additional, Campsie, Paul, additional, Scurr, David, additional, Childs, Peter G., additional, Phillips, David, additional, Donnelly, Sam, additional, Wells, Julia A., additional, O’Brien, Fergal J., additional, Salmeron-Sanchez, Manuel, additional, Burgess, Karl, additional, Alexander, Morgan, additional, Vassalli, Massimo, additional, Oreffo, Richard O. C., additional, Reid, Stuart, additional, France, David J., additional, and Dalby, Matthew J., additional

Published
2021
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9. The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

Author

Hodgkinson, Thomas, primary, Tsimbouri, P. Monica, additional, Llopis-Hernandez, Virginia, additional, Campsie, Paul, additional, Scurr, David, additional, Childs, Peter G, additional, Phillips, David, additional, Donnelly, Sam, additional, Wells, Julia A, additional, Salmeron-Sanchez, Manuel, additional, Burgess, Karl, additional, Alexander, Morgan, additional, Vassalli, Massimo, additional, Oreffo, Richard O.C., additional, Reid, Stuart, additional, France, David J, additional, and Dalby, Matthew J, additional

Published
2020
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10. Nanoscale coatings for ultralow dose BMP‐2‐driven regeneration of critical‐sized bone defects

Author

Cheng, Zhe A., Alba-Perez, Andres, Gonzalez-Garcia, Cristina, Donnelly, Hannah, Llopis-Hernandez, Virginia, Jayawarna, Vineetha, Childs, Peter, Shields, David W., Cantini, Marco, Ruiz-Cantu, Laura, Reid, Andrew, Windmill, James F.C., Addison, Elena S., Corr, Sandra, Marshall, William G., Dalby, Matthew J., and Salmeron-Sanchez, Manuel

Abstract

While new biomaterials for regenerative therapies are being reported in the literature, clinical translation is slow. Some existing regenerative approaches rely on high doses of growth factors, such as bone morphogenetic protein‐2 (BMP‐2) in bone regeneration, which can cause serious side effects. An ultralow‐dose growth factor technology is described yielding high bioactivity based on a simple polymer, poly(ethyl acrylate) (PEA), and mechanisms to drive stem cell differentiation and bone regeneration in a critical‐sized murine defect model with translation to a clinical veterinary setting are reported. This material‐based technology triggers spontaneous fibronectin organization and stimulates growth factor signalling, enabling synergistic integrin and BMP‐2 receptor activation in mesenchymal stem cells. To translate this technology, plasma‐polymerized PEA is used on 2D and 3D substrates to enhance cell signalling in vitro, showing the complete healing of a critical‐sized bone injury in mice in vivo. Efficacy is demonstrated in a Münsterländer dog with a nonhealing humerus fracture, establishing the clinical translation of advanced ultralow‐dose growth factor treatment.

Published
2019

12. High Efficiency BMP-2 Coatings: Nanoscale Coatings for Ultralow Dose BMP-2-Driven Regeneration of Critical-Sized Bone Defects (Adv. Sci. 2/2019)

Author

Cheng, Zhe A., primary, Alba-Perez, Andres, additional, Gonzalez-Garcia, Cristina, additional, Donnelly, Hannah, additional, Llopis-Hernandez, Virginia, additional, Jayawarna, Vineetha, additional, Childs, Peter, additional, Shields, David W., additional, Cantini, Marco, additional, Ruiz-Cantu, Laura, additional, Reid, Andrew, additional, Windmill, James F. C., additional, Addison, Elena S., additional, Corr, Sandra, additional, Marshall, William G., additional, Dalby, Matthew J., additional, and Salmeron-Sanchez, Manuel, additional

Published
2019
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13. Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects

Author

Cheng, Zhe A., primary, Alba‐Perez, Andres, additional, Gonzalez‐Garcia, Cristina, additional, Donnelly, Hannah, additional, Llopis‐Hernandez, Virginia, additional, Jayawarna, Vineetha, additional, Childs, Peter, additional, Shields, David W., additional, Cantini, Marco, additional, Ruiz‐Cantu, Laura, additional, Reid, Andrew, additional, Windmill, James F. C., additional, Addison, Elena S., additional, Corr, Sandra, additional, Marshall, William G., additional, Dalby, Matthew J., additional, and Salmeron‐Sanchez, Manuel, additional

Published
2018
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14. Review of emerging nanotechnology in bone regeneration: progress, challenges, and perspectives.

Author

Hajiali H, Ouyang L, Llopis-Hernandez V, Dobre O, and Rose FRAJ

Subjects
Biocompatible Materials, Bone Regeneration, Nanotechnology, Regenerative Medicine, Nanostructures, Tissue Engineering
Abstract

The application of nanotechnology to regenerative medicine has increased over recent decades. The development of materials that can influence biology at the nanoscale has gained interest as our understanding of the interactions between cells and biomaterials at the nanoscale has grown. Materials that are either nanostructured or influence the nanostructure of the cellular microenvironment have been developed and shown to have advantages over their microscale counterparts. There are several reviews which have been published that discuss how nanomaterials have been used in regenerative medicine, particularly in bone regeneration. Most of these studies have explored this concept in specific areas, such as the application of glass-based nanocomposites, nanotechnology for targeted drug delivery to stimulate bone repair, and the progress in nanotechnology for the treatment of osteoporosis. In this review paper, the impact of nanotechnology in biomaterials development for bone regeneration will be discussed highlighting specifically, nanostructured materials that influence mechanical properties, biocompatibility, and osteoinductivity.

Published
2021
Full Text
View/download PDF

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