Search

Your search keyword '"Llopis, Jaume"' showing total 218 results
Start Over Author "Llopis, Jaume"
218 results on '"Llopis, Jaume"'

1. Correction: Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000–2012)

Author

Ambrosioni, Juan, Hernández-Meneses, Marta, Durante-Mangoni, Emanuele, Tattevin, Pierre, Olaison, Lars, Freiberger, Tomas, Hurley, John, Hannan, Margaret M., Chu, Vivian, Hoen, Bruno, Moreno, Asunción, Cuervo, Guillermo, Llopis, Jaume, and Miró, José M.

Published
2023
Full Text
View/download PDF

2. Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000–2012)

Author

Ambrosioni, Juan, Hernández-Meneses, Marta, Durante-Mangoni, Emanuele, Tattevin, Pierre, Olaison, Lars, Freiberger, Tomas, Hurley, John, Hannan, Margaret M., Chu, Vivian, Hoen, Bruno, Moreno, Asunción, Cuervo, Guillermo, Llopis, Jaume, and Miró, José M.

Published
2023
Full Text
View/download PDF

5. The hidden side of infective endocarditis: Diagnostic and management of 500 consecutive cases in noncardiac surgery centers (2009–2018)

Author

Miró, Jose M., Ambrosioni, Juan, Hernández-Meneses, Marta, Téllez, Adrian, Pericàs, Juan M., Dahl, Anders, Moreno, Asuncion, Aguilar, Sergi, López, Alba, García de la Mària, Cristina, Cañas-Pacheco, María Alejandra, García-González, Javier, Almela, Manel, Zboromyrska, Yuliya, Casals, Climent, Morales, Francisco-Javier, Bosch, Jordi, Marco, Francesc, Vila, Jordi, Quintana, Eduard, Sandoval, Elena, Paré, Juan C., Falces, Carlos, Pereda, Daniel, Cartañá, Ramon, Ninot, Salvador, Azqueta, Manel, Sitges, Marta, Vidal, Barbara, Pomar, José L., Castella, Manuel, Tolosana, José M., Regueiro, Anders, Ortiz, José, Fita, Guillermina, Rovira, Irene, Perissinotti, Andrés, Fuster, David, Ramírez, Jose, Brunet, Mercè, Soy, Dolors, Castro, Pedro, Nicolás, David, Llopis, Jaume, Calzado, Sonia, Gasch, Oriol, Gomila-Grange, Aina, Pedrosa, Marc, Alguacil, Marina, Sanfeliu, Isabel, Guillaumet, Eva, Guillamon, Laura, Caresia, Ana Paula, Díaz, Emilio, Boix-Palop, Lucía, Dietl, Beatriz, Gisbert, Laura, Calbo, Esther, Xercavins, Mariona, Ibars, Sonia, Trenado, Josep, de los Ríos, Javier Díez, Reynaga, Esteban Alberto, Navarro, María, Montserrat, Silvia, Robles, Rocío, Cuquet, Jordi, Arrieta, Itziar, Costa, Núria, Martí, Carmina, Pulido, Ángeles, Ayats, Montserrat, Garro, Pau, Esquirol, Xavier, Bustamante, Marco A., Sanmartí, Montserrat, Cárdenas, Antonio, García, Gloria, Andrés, Marta, García, María Consuelo, Hanacsek, Carme Agustí, Dorca, Esther, Ortiz, María, Roca, Juan Manuel, Mollet, Fundació Sanitària, Tricas, José Maria, Maur, Elisabet, Romeo, Isabel, Vidal-Galve, Rosa, García, Xelo, Agustí, Carme, Tricas, José M., Díez de los Ríos, Javier, and Miró, José M.

Published
2023
Full Text
View/download PDF

6. Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci

Author

Téllez, Adrián, Ambrosioni, Juan, Hernández-Meneses, Marta, Llopis, Jaume, Ripa, Marco, Chambers, Stephen T., Holland, David, Almela, Manel, Fernández-Hidalgo, Núria, Almirante, Benito, Bouza, Emilio, Strahilevitz, Jacob, Hannan, Margaret M, Harkness, John, Kanafani, Zeina A., Lalani, Tahaniyat, Lang, Selwyn, Raymond, Nigel, Read, Kerry, Vinogradova, Tatiana, Woods, Christopher W., Wray, Dannah, Moreno, Asuncion, Chu, Vivian H., and Miro, Jose M

Published
2022
Full Text
View/download PDF

7. Reply to Garcia-Granja et al

Author

Hospital Clinic Infective Endocarditis Investigators, Ambrosioni, Juan, Tellez, Adrian, Hernandez-Meneses, Marta, Llopis, Jaume, Moreno, Asuncion, and Miró, José M.

Published
2018

8. Reply to Cuervo et al

Author

Hospital Clinic Infective Endocarditis Investigators, Ambrosioni, Juan, Urra, Xabier, Llopis, Jaume, Moreno, Asuncion, Chamorro, Angel, and Miró, José M.

Published
2018

9. Epidemiology, Clinical Features, and Outcome of Infective Endocarditis due to Abiotrophia Species and G ranulicatella Species : Report of 76 Cases, 2000–2015

Author

Hospital Clínic Infective Endocarditis Investigators, Téllez, Adrián, Ambrosioni, Juan, Llopis, Jaume, Pericàs, Juan M., Falces, Carles, Almela, Manel, de la Mària, Cristina Garcia, Hernandez-Meneses, Marta, Vidal, Bàrbara, Sandoval, Elena, Quintana, Eduard, Fuster, David, Tolosana, José M., Marco, Francesc, Moreno, Asunción, and Miro, José M.

Published
2018

11. The hidden side of infective endocarditis: Diagnostic and management of 500 consecutive cases in noncardiac surgery centers (2009–2018)

Author

Calzado, Sonia, primary, Hernández-Meneses, Marta, additional, Llopis, Jaume, additional, Boix-Palop, Lucía, additional, Dietl, Beatriz, additional, Calbo, Esther, additional, Andrés, Marta, additional, García, Xelo, additional, Agustí, Carme, additional, Dorca, Esther, additional, Tricas, José M., additional, Díez de los Ríos, Javier, additional, Cuquet, Jordi, additional, Cárdenas, Antonio, additional, Roca, Juan Manuel, additional, Ortiz, María, additional, Caresia, Ana Paula, additional, Guillamon, Laura, additional, Quintana, Eduard, additional, Ambrosioni, Juan, additional, Gasch, Oriol, additional, Miró, José M., additional, Miró, Jose M., additional, Téllez, Adrian, additional, Pericàs, Juan M., additional, Dahl, Anders, additional, Moreno, Asuncion, additional, Aguilar, Sergi, additional, López, Alba, additional, García de la Mària, Cristina, additional, Cañas-Pacheco, María Alejandra, additional, García-González, Javier, additional, Almela, Manel, additional, Zboromyrska, Yuliya, additional, Casals, Climent, additional, Morales, Francisco-Javier, additional, Bosch, Jordi, additional, Marco, Francesc, additional, Vila, Jordi, additional, Sandoval, Elena, additional, Paré, Juan C., additional, Falces, Carlos, additional, Pereda, Daniel, additional, Cartañá, Ramon, additional, Ninot, Salvador, additional, Azqueta, Manel, additional, Sitges, Marta, additional, Vidal, Barbara, additional, Pomar, José L., additional, Castella, Manuel, additional, Tolosana, José M., additional, Regueiro, Anders, additional, Ortiz, José, additional, Fita, Guillermina, additional, Rovira, Irene, additional, Perissinotti, Andrés, additional, Fuster, David, additional, Ramírez, Jose, additional, Brunet, Mercè, additional, Soy, Dolors, additional, Castro, Pedro, additional, Nicolás, David, additional, Calzado, Sonia, additional, Gomila-Grange, Aina, additional, Pedrosa, Marc, additional, Alguacil, Marina, additional, Sanfeliu, Isabel, additional, Guillaumet, Eva, additional, Díaz, Emilio, additional, Gisbert, Laura, additional, Xercavins, Mariona, additional, Ibars, Sonia, additional, Trenado, Josep, additional, de los Ríos, Javier Díez, additional, Reynaga, Esteban Alberto, additional, Navarro, María, additional, Montserrat, Silvia, additional, Robles, Rocío, additional, Arrieta, Itziar, additional, Costa, Núria, additional, Martí, Carmina, additional, Pulido, Ángeles, additional, Ayats, Montserrat, additional, Garro, Pau, additional, Esquirol, Xavier, additional, Bustamante, Marco A., additional, Sanmartí, Montserrat, additional, García, Gloria, additional, García, María Consuelo, additional, Hanacsek, Carme Agustí, additional, Mollet, Fundació Sanitària, additional, Tricas, José Maria, additional, Maur, Elisabet, additional, Romeo, Isabel, additional, and Vidal-Galve, Rosa, additional

Published
2023
Full Text
View/download PDF

13. Infective Endocarditis After Transcatheter versus Surgical Aortic Valve Replacement

Author

Panagides, Vassili, primary, Cuervo, Guillermo, additional, Llopis, Jaume, additional, Abdel-Wahab, Mohamed, additional, Mangner, Norman, additional, Habib, Gilbert, additional, Regueiro, Ander, additional, Mestres, Carlos, additional, Tornos, Pilar, additional, Durand, Eric, additional, Selton-Suty, Christine, additional, Ihlemann, Nikolaj, additional, Bruun, Niels, additional, Urena, Marina, additional, Cecchi, Enrico, additional, Thiele, Holger, additional, Durante-Mangoni, Emanuele, additional, Pellegrini, Costanza, additional, Eltchaninoff, Helene, additional, Athan, Eugene, additional, Søndergaard, Lars, additional, Linke, Axel, additional, Tattevin, Pierre, additional, del Val, David, additional, Quintana, Eduard, additional, Chu, Vivian, additional, Rodés-Cabau, Josep, additional, and Miro, Jose M, additional

Published
2023
Full Text
View/download PDF

14. The three-noes right-sided infective endocarditis: An unrecognized type of right-sided endocarditis

Author

Cabezón, Gonzalo, primary, López, Javier, additional, Vilacosta, Isidre, additional, Habib, Gilbert, additional, Miró, José María, additional, Olmos, Carmen, additional, Sarriá, Cristina, additional, Hernandez-Meneses, Marta, additional, González-Juanatey, Carlos, additional, González-Juanatey, José Ramón, additional, Llopis, Jaume, additional, Cuervo, Guillermo, additional, Sáez, Carmen, additional, Gómez, Itziar, additional, and San Román, J. Alberto, additional

Published
2023
Full Text
View/download PDF

17. Infective Endocarditis After Transcatheter Versus Surgical Aortic Valve Replacement.

Author

Panagides, Vassili, Cuervo, Guillermo, Llopis, Jaume, Abdel-Wahab, Mohamed, Mangner, Norman, Habib, Gilbert, Regueiro, Ander, Mestres, Carlos A, Tornos, Pilar, Durand, Eric, Selton-Suty, Christine, Ihlemann, Nikolaj, Bruun, Niels, Urena, Marina, Cecchi, Enrico, Thiele, Holger, Durante-Mangoni, Emanuele, Pellegrini, Costanza, Eltchaninoff, Helene, and Athan, Eugene

Subjects
REPORTING of diseases, HEART valve prosthesis implantation, INFECTIVE endocarditis, TREATMENT effectiveness, COMPARATIVE studies, BIOPROSTHETIC heart valves, PROSTHETIC heart valves, RESEARCH funding, AORTIC valve insufficiency, SYMPTOMS
Abstract

Background Scarce data are available comparing infective endocarditis (IE) following surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). This study aimed to compare the clinical presentation, microbiological profile, management, and outcomes of IE after SAVR versus TAVR. Methods Data were collected from the "Infectious Endocarditis after TAVR International" (enrollment from 2005 to 2020) and the "International Collaboration on Endocarditis" (enrollment from 2000 to 2012) registries. Only patients with an IE affecting the aortic valve prosthesis were included. A 1:1 paired matching approach was used to compare patients with TAVR and SAVR. Results A total of 1688 patients were included. Of them, 602 (35.7%) had a surgical bioprosthesis (SB), 666 (39.5%) a mechanical prosthesis, 70 (4.2%) a homograft, and 350 (20.7%) a transcatheter heart valve. In the SAVR versus TAVR matched population, the rate of new moderate or severe aortic regurgitation was higher in the SB group (43.4% vs 13.5%; P <.001), and fewer vegetations were diagnosed in the SB group (62.5% vs 82%; P <.001). Patients with an SB had a higher rate of perivalvular extension (47.9% vs 27%; P <.001) and Staphylococcus aureus was less common in this group (13.4% vs 22%; P =.033). Despite a higher rate of surgery in patients with SB (44.4% vs 27.3%; P <.001), 1-year mortality was similar (SB: 46.5%; TAVR: 44.8%; log-rank P =.697). Conclusions Clinical presentation, type of causative microorganism, and treatment differed between patients with an IE located on SB compared with TAVR. Despite these differences, both groups exhibited high and similar mortality at 1-year follow-up. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

18. Effects of Bariatric Surgery on Blood and Vascular Large Extracellular Vesicles According to Type 2 Diabetes Status.

Author

Pané, Adriana, Viaplana, Judith, Giró, Oriol, Llopis, Jaume, Ibarzabal, Ainitze, Hollanda, Ana de, Vidal, Josep, Ortega, Emilio, Jiménez, Amanda, and Chiva-Blanch, Gemma

Subjects
EXTRACELLULAR vesicles, BARIATRIC surgery, TYPE 2 diabetes diagnosis
Abstract

Context Large extracellular vesicles (lEVs) enriched for endothelial and blood cell markers are increased in metabolic conditions such as obesity or type 2 diabetes (T2D), actively contribute to the atherosclerotic process, and have been identified as diagnostic and prognostic biomarkers for cardiovascular disease (CVD). Although bariatric surgery (BS) in individuals with obesity is related to decreased cardiovascular (CV) risk and increased life expectancy, after BS these subjects are still at higher CV risk than the general population. Objective We aimed to compare the lEV profiles between individuals with obesity, with or without T2D, before and 1 year after BS, and normal-weight controls. Methods Prospective longitudinal study with individuals eligible for BS, with or without T2D (T2D and OB groups, respectively) and healthy controls (HC group) matched by age and sex. The concentration and phenotype of lEVs were assessed by flow cytometry. Results The study cohort included 108 individuals (age 48.0 ± 10.5 years; 84.3% females). Before BS, the OB group presented higher concentrations of lEV enriched for endothelial and blood cell biomarkers than the HC group, but lower concentrations than those observed in the T2D group (P <.05). BS resulted in a significant reduction in most of the lEVs enriched for cell-specific markers in both subgroups. lEV differences between OB and T2D groups were no longer observed after BS (P >.05). However, compared with HC group, OB and T2D groups still showed increased concentrations of lEVs enriched for platelet and endothelial cell markers (P <.05). Conclusion At 1 year after BS, lEV concentrations remain above the physiological range. These abnormalities might contribute to explaining the increased CV risk after BS and underscore the importance of long-term CV risk factor control in post-BS individuals. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

20. Does Gender Have an Impact on the Potential Benefits Learners May Achieve in Two Contexts Compared: Formal Instruction and Formal Instruction + Content and Language Integrated Learning?

Author

Roquet, Helena, Llopis, Jaume, and Pérez-Vidal, Carmen

Abstract

This study focuses on the degree of influence of one individual factor, namely gender, on the level of English competence attained in two different groups of intermediate-level Catalan Spanish adolescent learners of English as a foreign language: the first group (Group A) is 1 year younger and follows formal instruction (FI) and in parallel content and language integrated learning (CLIL) instruction (FI + CLIL). That is, the group receives some 'extra' hours which are CLIL hours. The second group (Group B) follows a FI only programme. Data were elicited both for receptive and production skills, except speaking, and were statistically analysed using a pretest-posttest design over one academic year. Results obtained, contrary to expectations, confirm that female participants are better than male participants in both contexts of acquisition although not in all skills and domains analysed.

Published
2016
Full Text
View/download PDF

23. Reappraisal of [18F]FDG-PET/CT for diagnosis and management of cardiac implantable electronic device infections

Author

Meneses, Marta Hernández, primary, Perissinotti, Andrés, additional, Martínez, Silvia Páez, additional, Llopis, Jaume, additional, Dahl, Anders, additional, Sandoval, Elena, additional, Falces, Carlos, additional, Ambrosioni, Juan, additional, Vidal, Bárbara, additional, Marco, Francesc, additional, Cuervo, Guillermo, additional, Moreno, Asunción, additional, Bosch, Jordi, additional, Tolosana, José M, additional, Fuster, David, additional, and Miró, José M, additional

Published
2023
Full Text
View/download PDF

24. Left-sided infective endocarditis in patients with liver cirrhosis

Author

Sánchez, Fernando Fernández, Noureddine, Marian, Rosas, Gabriel, de la Torre Lima, Javier, Aramendi, José, Bereciartua, Elena, Boado, María Victoria, Lázaro, Marta Campaña, Goiti, Juan José, Hernández, José Luis, Iruretagoyena, José Ramón, Zuazabal, Josu Irurzun, López-Soria, Leire, Montejo, Miguel, Pérez, Pedro María, Rodríguez, Regino, Voces, Roberto, García López, Mª Victoria, Solero, Manuel Márquez, Bailón, Isabel Rodríguez, Espín, Gemma Sanchez, Otero, Juan, Cuende, Ana María, Gaminde, Eduardo, Idígoras, Pedro, Iribarren, José Antonio, Yarza, Alberto Izaguirre, Reviejo, Carlos, Echeverría, Tomás, Fuertes, Ana, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, del Mar Carmona, María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Rey, Enrique Miguez, Mayo, María Rodríguez, Sousa, Dolores, Zúñiga, Mª Carmen, Martínez-Marcos, Francisco Javier, Lomas Cabezas, J.M., del Mar Alonso, Mª, Castro, Beatriz, Marrero, Dácil García, del Carmen Durán, Mª, Miguel Gómez, Mª Antonia, La Calzada, Juan, Nassar, Ibrahim, Reguera Iglesias, José Mª, Álvarez, Víctor Asensi, Costas, Carlos, de la Hera, Jesús, Suárez, Jonnathan Fernández, García Ruiz, José Manuel, Fraile, Lisardo Iglesias, Menéndez, José López, Bajo, Pilar Mencia, Morales, Carlos, Torrico, Alfonso Moreno, Palomo, Carmen, Martínez, Begoña Paya, Rodríguez, Ángeles, García, Raquel Rodríguez, Telenti, Mauricio, Almela, Manuel, Armero, Yolanda, Azqueta, Manuel, Castañeda, Ximena, Cervera, Carlos, Falces, Carlos, García-de-la-Maria, Cristina, Gatell, José M., Llopis, Jaume, Marco, Francesc, Mestres, Carlos A., Moreno, Asunción, Ninot, Salvador, Ramírez, José, Sitges, Marta, Paré, Carlos, Pericás, Juan M., Bermejo, Javier, Bouza, Emilio, de Egea, Viviana, Eworo, Alia, Cruz, Ana Fernández, Leoni, Mª Eugenia García, del Vecchio, Marcela González, Ramallo, Víctor González, Hernández, Martha Kestler, Marín, Mercedes, Martínez-Sellés, Manuel, Menárguez, Mª Cruz, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Roda, Jorge Rodríguez, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Moreno, Eduardo Verde, Antorrena, Isabel, Moreno, Mar, Paño, José Ramón, Rosillo, Sandra, Romero, María, Saldaña, Araceli, Castillo, Carlos Armiñanzas, Arnaiz, Ana, Berrazueta, José, Bellisco, Sara, Belaustegui, Manuel Cobo, Durán, Raquel, Fariñas-Álvarez, Concepción, Mazarrasa, Carlos Fernández, Izquierdo, Rubén Gómez, Rico, Claudia González, Díez, José Gutiérrez, Durán, Rafael Martín, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Pavía, Pablo García, González, Jesús, Orden, Beatriz, Ramos, Antonio, González, Elena Rodríguez, Centella, Tomasa, Hermida, José, Moya, José, Martínez, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Ruiz, Soledad, de Castro, Antonio, de Cueto, Marina, Gallego, Pastora, Rodríguez Baño, Jesús, Lepe, José Antonio, Luque Márquez, Rafael, Gutiérrez-Carretero, Encarnación, Galán, Julia Eslava, Alonso, Luis Javier, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, García, Lara, Oteo, José Antonio, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Canut Blasco, Andrés, Mollar, José Cordo, Gainzarain Arana, Juan Carlos, Uriarte, Oscar García, López, Alejandro Martín, de Zárate, Zuriñe Ortiz, Urturi Matos, José Antonio, Nacle, Mª Belén, Sánchez, Antonio, Vallejo, Luis, Arribas Leal, José Mª, Vázquez, Elisa García, Torres, Alicia Hernández, Gómez, Joaquín Ruiz, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Rodríguez, Anai Moreno, Tarabini-Castellani, Paola, Gálvez, Eva Heredero, Bellido, Carolina Maicas, Sepúlveda, Mª Antonia, Alcolea, Eva Cascales, Egea Serrano, Pilar, Hernández Roca, José Joaquín, Ruiz-Morales, J., Ivanova-Georgieva, R., Fernández-Hidalgo, N., García-Cabrera, E., Miró, Jose M., Muñoz, P., Almirante, B., Plata-Ciézar, A., González-Ramallo, V., Gálvez-Acebal, J., Fariñas, M.C., Bravo-Ferrer, J.M., Goenaga-Sánchez, M.A., Hidalgo-Tenorio, C., Goikoetxea-Agirre, J., and de Alarcón-González, A.

Published
2015
Full Text
View/download PDF

27. Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study

Author

Bodro, Marta, Cervera, Carlos, Linares, Laura, Suárez, Belén, Llopis, Jaume, Sanclemente, Gemma, Casadó-Llombart, Sergi, Fernández Ruiz, Mario, Fariñas, María Carmen, Cantisan, Sara, Montejo, Miguel, Cordero, Elisa, Oriol, Isabel, Marcos, Ma. Angeles, Lozano Soto, Francisco, Moreno, A. (Asunción), Gesitra-ic/seimc/reipi Investigators, Universidad de Cantabria, Instituto de Salud Carlos III, European Commission, Red Española de Investigación en Patología Infecciosa, Ministerio de Ciencia, Innovación y Universidades (España), and Agencia Estatal de Investigación (España)

Subjects
infectious disease, Immunology, Cytomegalovirus, Antiviral Agents, Mannose-Binding Lectin, Cytomegaloviruses, Solid organ transplantation, Immunology and Allergy, Humans, Prospective Studies, cytomegalovirus, innate immunity, solid organ transplantation, Ganciclovir, Innate immunity, Infectious disease, Transplantation of organs, Immunity, Immunity, Innate, Transplant Recipients, Multicenter study, Toll-Like Receptor 3, Toll-Like Receptor 4, Trasplantament d'òrgans, multicenter study, Immunitat, Toll-Like Receptor 7, Toll-Like Receptor 9, Cytomegalovirus Infections, Citomegalovirus
Abstract

Several genetic polymorphisms of the innate immune system have been described to increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this study was to assess the impact of a polygenic score to predict CMV infection and disease in high risk CMV transplant recipients (heart, liver, kidney or pancreas). On hundred and sixteen CMV-seronegative recipients of grafts from CMV-seropositive donors undergoing heart, liver, and kidney or pancreas transplantation from 7 centres were prospectively included for this purpose during a 2-year period. All recipients received 100-day prophylaxis with valganciclovir. CMV infection occurred in 61 patients (53%) at 163 median days from transplant, 33 asymptomatic replication (28%) and 28 CMV disease (24%). Eleven patients (9%) had recurrent CMV infection. Clinically and/or functionally relevant single nucleotide polymorphisms (SNPs) from TLR2, TLR3, TLR4, TLR7, TLR9, AIM2, MBL2, IL28, IFI16, MYD88, IRAK2 and IRAK4 were assessed by real time polymerase chain reaction (RT-PCR) or sequence-based typing (PCR-SBT). A polygenic score including the TLR4 (rs4986790/rs4986791), TLR9 (rs3775291), TLR3 (rs3775296), AIM2 (rs855873), TLR7 (rs179008), MBL (OO/OA/XAO), IFNL3/IL28B (rs12979860) and IFI16 (rs6940) SNPs was built based on the risk of CMV infection and disease. The CMV score predicted the risk of CMV disease with an AUC of the model of 0.68, with sensitivity and specificity of 64.3 and 71.6%, respectively. Even though further studies are needed to validate this score, its use would represent an effective model to develop more robust scores predicting the risk of CMV disease in donor/recipient mismatch (D+/R-) transplant recipients., This work was supported by Spanish Ministerio de Sanidad y Consumo (FIS PI12/01743), Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional (FEDER). Unión Europea. “Una manera de hacer Europa”; Network for the Research in Infectious Diseases (REIPI) from the Instituto de Salud Carlos III, Madrid, Spain; and Ministerio de Ciencia e Innovación (PID2019-106658RB-I00, funded by MCIN/AEI/10.13039/501100011033). MF-R holds a research contract “Miguel Servet” (CP18/00073) from the Instituto de Salud Carlos III, Spanish Ministerio de Ciencia e Innovación.

Published
2022

28. Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences

Author

Biezma, María, Muñoz, Patricia, Villa, Sofía de la, Fariñas Álvarez, María, Arnáiz de las Revillas, Francisco, Gutiérrez Carretero, Encarnación, Alarcón, Arístides de, Rodríguez García, Raquel, Llopis, Jaume, Goenaga, Miguel, Gutiérrez Villanueva, Andrea, Plata, Antonio, Vidal, Laura, Martínez Sellés d'Oliveira Soares, Manuel, Biezma, María, Muñoz, Patricia, Villa, Sofía de la, Fariñas Álvarez, María, Arnáiz de las Revillas, Francisco, Gutiérrez Carretero, Encarnación, Alarcón, Arístides de, Rodríguez García, Raquel, Llopis, Jaume, Goenaga, Miguel, Gutiérrez Villanueva, Andrea, Plata, Antonio, Vidal, Laura, and Martínez Sellés d'Oliveira Soares, Manuel

Abstract

Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods. Retrospective analysis of the Spanish IE Registry (2008–2020). Results. The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16–1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21–1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06–1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26–2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2022

29. Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study

Author

Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS203 : Estudio de las enfermedades infecciosas, Ministerio de Sanidad y Consumo. España, Ministerio de Ciencia e Innovación. España, Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional (FEDER). Unión Europea., Bodro, Marta, Cervera, Carlos, Linares, Laura, Suárez, Belén, Llopis, Jaume, Sanclemente, Gemma, Cordero Matia, María Elisa, Moreno, Asunción, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. CTS203 : Estudio de las enfermedades infecciosas, Ministerio de Sanidad y Consumo. España, Ministerio de Ciencia e Innovación. España, Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional (FEDER). Unión Europea., Bodro, Marta, Cervera, Carlos, Linares, Laura, Suárez, Belén, Llopis, Jaume, Sanclemente, Gemma, Cordero Matia, María Elisa, and Moreno, Asunción

Abstract

Several genetic polymorphisms of the innate immune system have been described to increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this study was to assess the impact of a polygenic score to predict CMV infection and disease in high risk CMV transplant recipients (heart, liver, kidney or pancreas). On hundred and sixteen CMV-seronegative recipients of grafts from CMV-seropositive donors undergoing heart, liver, and kidney or pancreas transplantation from 7 centres were prospectively included for this purpose during a 2-year period. All recipients received 100-day prophylaxis with valganciclovir. CMV infection occurred in 61 patients (53%) at 163 median days from transplant, 33 asymptomatic replication (28%) and 28 CMV disease (24%). Eleven patients (9%) had recurrent CMV infection. Clinically and/or functionally relevant single nucleotide polymorphisms (SNPs) from TLR2, TLR3, TLR4, TLR7, TLR9, AIM2, MBL2, IL28, IFI16, MYD88, IRAK2 and IRAK4 were assessed by real time polymerase chain reaction (RT-PCR) or sequence-based typing (PCR-SBT). A polygenic score including the TLR4 (rs4986790/rs4986791), TLR9 (rs3775291), TLR3 (rs3775296), AIM2 (rs855873), TLR7 (rs179008), MBL (OO/OA/XAO), IFNL3/IL28B (rs12979860) and IFI16 (rs6940) SNPs was built based on the risk of CMV infection and disease. The CMV score predicted the risk of CMV disease with an AUC of the model of 0.68, with sensitivity and specificity of 64.3 and 71.6%, respectively. Even though further studies are needed to validate this score, its use would represent an effective model to develop more robust scores predicting the risk of CMV disease in donor/ recipient mismatch (D+/R-) transplant recipients.

Published
2022

30. Outpatient Parenteral Antibiotic Treatment vs Hospitalization for Infective Endocarditis: Validation of the OPAT-GAMES Criteria

Author

Universidad de Sevilla. Departamento de Cirugía, Universidad de Sevilla. Departamento de Microbiología, Pericas, Juan M., Llopis, Jaume, González Ramallo, Victor, García Leoni, M. Eugenia, Arístides de Alarcón, Rafael Luque, Fariñas, M. Carmen, Araji Tiliani, Omar, Cueto López, Marina de, Gálvez Acebal, Juan, Lepe Jiménez, José Antonio, Universidad de Sevilla. Departamento de Cirugía, Universidad de Sevilla. Departamento de Microbiología, Pericas, Juan M., Llopis, Jaume, González Ramallo, Victor, García Leoni, M. Eugenia, Arístides de Alarcón, Rafael Luque, Fariñas, M. Carmen, Araji Tiliani, Omar, Cueto López, Marina de, Gálvez Acebal, Juan, and Lepe Jiménez, José Antonio

Abstract

Background. Outpatient parenteral antibiotic treatment (OPAT) programs are increasingly used to manage infective endocarditis (IE), but current criteria for indicating OPAT are markedly conservative. We aimed to investigate whether more liberal criteria for indicating OPAT in IE can be safely used. Methods. This was a prospective multicenter nationwide cohort study (2008–2018). Rates of readmission, recurrences, and 1-year mortality were compared between hospital-based antibiotic treatment (HBAT) and OPAT. Risk factors for readmission and mortality in OPAT patients were investigated by logistic regression. Patients did not fulfill OPAT-GAMES (Grupos de Apoyo al Manejo de la Endocarditis en ESpaña) criteria if they had any of the following: cirrhosis, severe central nervous system emboli, undrained abscesses, severe conditions requiring cardiac surgery in nonoperable patients, severe postsurgical complications, highly difficult-to-treat microorganisms, or intravenous drug use. Results. A total of 2279 HBAT patients and 1268 OPAT patients were included. Among OPAT patients, 307 (24.2%) did not fulfill OPAT-GAMES criteria. Overall, OPAT patients presented higher rates of readmission than HBAT patients (18.2% vs 14.4%; P =.004), but no significant differences were found in the propensity analysis. Patients not fulfilling OPAT-GAMES criteria presented significantly higher rates of readmission than HBAT and OPAT-GAMES (23.8%, 14.4%, 16.4%; P<.001), whereas no significant differences were found in mortality (5.9%, 8%, 7.4%; P=.103) or recurrences (3.9%, 3.1%, 2.5%; P=.546). Not fulfilling OPAT-GAMES criteria was associated with higher risk of readmission (odds ratio [OR], 1.43; 95% CI, 1.03–1.97; P=.03), whereas cardiac surgery was associated with lower risk (OR, 0.72; 95% CI, 0.53–0.98; P=.03). Conclusions. OPAT-GAMES criteria allow identification of IE patients at higher risk of long-term complications to whom OPAT cannot be safely administered.

Published
2022

31. Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study

Author

Instituto de Salud Carlos III, European Commission, Red Española de Investigación en Patología Infecciosa, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Bodro, Marta, Cervera, Carlos, Linares, Laura, Suárez, Belén, Llopis, Jaume, Sanclemente, Gemma, Casadó-Llombart, Sergi, Fernández-Ruiz, Mario, Fariñas, María del Carmen, Cantisán, Sara, Montejo, Miguel, Cordero, Elisa, Oriol, Isabel, Marcos, María Ángeles, Lozano, Francisco, Moreno, Asunción, GESITRA-IC/SEIMC/REIPI, Instituto de Salud Carlos III, European Commission, Red Española de Investigación en Patología Infecciosa, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Bodro, Marta, Cervera, Carlos, Linares, Laura, Suárez, Belén, Llopis, Jaume, Sanclemente, Gemma, Casadó-Llombart, Sergi, Fernández-Ruiz, Mario, Fariñas, María del Carmen, Cantisán, Sara, Montejo, Miguel, Cordero, Elisa, Oriol, Isabel, Marcos, María Ángeles, Lozano, Francisco, Moreno, Asunción, and GESITRA-IC/SEIMC/REIPI

Abstract

Several genetic polymorphisms of the innate immune system have been described to increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this study was to assess the impact of a polygenic score to predict CMV infection and disease in high risk CMV transplant recipients (heart, liver, kidney or pancreas). On hundred and sixteen CMV-seronegative recipients of grafts from CMV-seropositive donors undergoing heart, liver, and kidney or pancreas transplantation from 7 centres were prospectively included for this purpose during a 2-year period. All recipients received 100-day prophylaxis with valganciclovir. CMV infection occurred in 61 patients (53%) at 163 median days from transplant, 33 asymptomatic replication (28%) and 28 CMV disease (24%). Eleven patients (9%) had recurrent CMV infection. Clinically and/or functionally relevant single nucleotide polymorphisms (SNPs) from TLR2, TLR3, TLR4, TLR7, TLR9, AIM2, MBL2, IL28, IFI16, MYD88, IRAK2 and IRAK4 were assessed by real time polymerase chain reaction (RT-PCR) or sequence-based typing (PCR-SBT). A polygenic score including the TLR4 (rs4986790/rs4986791), TLR9 (rs3775291), TLR3 (rs3775296), AIM2 (rs855873), TLR7 (rs179008), MBL (OO/OA/XAO), IFNL3/IL28B (rs12979860) and IFI16 (rs6940) SNPs was built based on the risk of CMV infection and disease. The CMV score predicted the risk of CMV disease with an AUC of the model of 0.68, with sensitivity and specificity of 64.3 and 71.6%, respectively. Even though further studies are needed to validate this score, its use would represent an effective model to develop more robust scores predicting the risk of CMV disease in donor/recipient mismatch (D+/R-) transplant recipients.

Published
2022

32. Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences

Author

Biezma, María Isabel, Muñoz, Patricia, Villa, Sofía de la, Fariñas, María del Carmen, Arnaiz-De Las Revillas, Francisco, Gutiérrez-Carretero, Encarnación, Alarcón González, Arístides de, Rodríguez-García, Raquel, Llopis, Jaume, Goenaga Sánchez, Miguel Ángel, Gutiérrez-Villanueva, Andrea, Plata-Ciezar, Antonio, Vidal Bonet, Laura, Martínez-Sellés, Manuel, GAMEs investigators, Biezma, María Isabel, Muñoz, Patricia, Villa, Sofía de la, Fariñas, María del Carmen, Arnaiz-De Las Revillas, Francisco, Gutiérrez-Carretero, Encarnación, Alarcón González, Arístides de, Rodríguez-García, Raquel, Llopis, Jaume, Goenaga Sánchez, Miguel Ángel, Gutiérrez-Villanueva, Andrea, Plata-Ciezar, Antonio, Vidal Bonet, Laura, Martínez-Sellés, Manuel, and GAMEs investigators

Abstract

[Background] Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage., [Methods] Retrospective analysis of the Spanish IE Registry (2008−2020)., [Results] The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16−1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21−1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06−1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26−2.01, p < 0.001), [Conclusions] The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage.

Published
2022

35. Forty-Year Trends in Cardiac Implantable Electronic Device Infective Endocarditis.

Author

Hernández-Meneses, Marta, Llopis, Jaume, Sandoval, Elena, Ninot, Salvador, Almela, Manel, Falces, Carlos, Pericàs, Juan M, Vidal, Bárbara, Perissinotti, Andrés, Marco, Francesc, Mestres, Carlos A, Paré, Carlos, María, Cristina García de la, Cuervo, Guillermo, Quintana, Eduard, Tolosana, José M, Moreno, Asunción, Miró, José M, and Investigators, for the Hospital Clinic Infective Endocarditis Team

Subjects
*ELECTRONIC equipment, *ENTEROCOCCAL infections, *INFECTIVE endocarditis, *ARTIFICIAL implants, *CARDIOVASCULAR surgery, *NOSOCOMIAL infections, *SEPTIC shock, *IMPLANTABLE cardioverter-defibrillators, *PULMONARY embolism
Abstract

Background Studies investigating cardiac implantable electronic device infective endocarditis (CIED-IE) epidemiological changes and prognosis over long periods of time are lacking. Methods Retrospective single cardiovascular surgery center cohort study of definite CIED-IE episodes between 1981–2020. A comparative analysis of two periods (1981–2000 vs 2001–2020) was conducted to analyze changes in epidemiology and outcome over time. Results One-hundred and thirty-eight CIED-IE episodes were diagnosed: 25 (18%) first period and 113 (82%) second. CIED-IE was 4.5 times more frequent in the second period, especially in implantable cardiac defibrillators. Age (63 [53-70] vs 71 [63–76] years, P <.01), comorbidities (CCI 3.0 [2–4] vs 4.5 [3–6], P >.01), nosocomial infections (4% vs 15.9%, P =.02) and transfers from other centers (8% vs 41.6%, P <.01) were significantly more frequent in the second period, as were methicillin-resistant coagulase-negative staphylococcal (MR-CoNS) (0% vs 13.3%, P <.01) and Enterococcus spp. (0% vs 5.3%, P =.01) infections, pulmonary embolism (0% vs 10.6%, P <.01) and heart failure (12% vs 28.3%, p <.01). Second period surgery rates were lower (96% vs 87.6%, P =.09), and there were no differences in in-hospital (20% vs 11.5%, P =.11) and one-year mortalities (24% vs 15%, P =.33), or relapses (8% vs 5.3%, P = 0.65). Multivariate analysis showed Charlson index (hazard ratios [95% confidence intervals]; 1.5 [1.16–1.94]) and septic shock (23.09 [4.57–116.67]) were associated with a worse prognosis, whereas device removal (0.11 [.02–.57]), transfers (0.13 [.02–0.95]), and second-period diagnosis (0.13 [.02–.71]) were associated with better one-year outcomes. Conclusions CIED-IE episodes increased more than four-fold during last 40 years. Despite CIED-IE involved an older population with more comorbidities, antibiotic-resistant MR-CoNS, and complex devices, one-year survival improved. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

36. Outcomes of Septal Myectomy beyond 65 Years, with and without Concomitant Procedures

Author

Pruna-Guillen, Robert, primary, Pereda, Daniel, additional, Castellà, Manuel, additional, Sandoval, Elena, additional, Affronti, Alessandro, additional, García-Álvarez, Ana, additional, Perdomo, Juan, additional, Ibáñez, Cristina, additional, Jordà, Paloma, additional, Prat-González, Susanna, additional, Alcocer, Jorge, additional, Barriuso, Clemente, additional, Llopis, Jaume, additional, and Quintana, Eduard, additional

Published
2021
Full Text
View/download PDF

37. Infective endocarditis in patients on chronic hemodialysis

Author

Pericàs, Juan M., Llopis, Jaume, Jiménez-Exposito, Maria Jesús, Kourany, Wissam M., Almirante, Benito, Carosi, Giampiero, Durante-Mangoni, Emanuele, Fortes, Claudio Querido, Giannitsioti, Efthymia, Lerakis, Stamatios, Montagna-Mella, Rodrigo, Ambrosioni, Juan, Tan, Ru-San, Mestres, Carlos A., Wray, Dannah, Pachirat, Orathai, Moreno, Asuncion, Chu, Vivian H., de Lazzari, Elisa, Fowler, Vance G., Athan, Eugene, Gordon, Pericàs, Juan M., Llopis, Jaume, Jiménez-Exposito, Maria Jesús, Kourany, Wissam M., Almirante, Benito, Carosi, Giampiero, Durante-Mangoni, Emanuele, Fortes, Claudio Querido, Giannitsioti, Efthymia, Lerakis, Stamatios, Montagna-Mella, Rodrigo, Ambrosioni, Juan, Tan, Ru-San, Mestres, Carlos A., Wray, Dannah, Pachirat, Orathai, Moreno, Asuncion, Chu, Vivian H., de Lazzari, Elisa, Fowler, Vance G., Athan, Eugene, and Gordon

Published
2021

38. Outpatient Parenteral Antibiotic Treatment vs Hospitalization for Infective Endocarditis: Validation of the OPAT-GAMES Criteria.

Author

Pericàs, Juan M, Llopis, Jaume, Muñoz, Patricia, González-Ramallo, Víctor, García-Leoni, M Eugenia, Alarcón, Arístides de, Luque, Rafael, Fariñas, M Carmen, Goenaga, Miguel Á, Hernández-Meneses, Marta, Nicolás, David, Ramos-Martínez, Antonio, Rodríguez-Esteban, M Ángeles, Villoslada-Gelabert, Aroa, Miró, José M, and Investigators, GAMES

Abstract

Background Outpatient parenteral antibiotic treatment (OPAT) programs are increasingly used to manage infective endocarditis (IE), but current criteria for indicating OPAT are markedly conservative. We aimed to investigate whether more liberal criteria for indicating OPAT in IE can be safely used. Methods This was a prospective multicenter nationwide cohort study (2008–2018). Rates of readmission, recurrences, and 1-year mortality were compared between hospital-based antibiotic treatment (HBAT) and OPAT. Risk factors for readmission and mortality in OPAT patients were investigated by logistic regression. Patients did not fulfill OPAT-GAMES (Grupos de Apoyo al Manejo de la Endocarditis en ESpaña) criteria if they had any of the following: cirrhosis, severe central nervous system emboli, undrained abscesses, severe conditions requiring cardiac surgery in nonoperable patients, severe postsurgical complications, highly difficult-to-treat microorganisms, or intravenous drug use. Results A total of 2279 HBAT patients and 1268 OPAT patients were included. Among OPAT patients, 307 (24.2%) did not fulfill OPAT-GAMES criteria. Overall, OPAT patients presented higher rates of readmission than HBAT patients (18.2% vs 14.4%; P = .004), but no significant differences were found in the propensity analysis. Patients not fulfilling OPAT-GAMES criteria presented significantly higher rates of readmission than HBAT and OPAT-GAMES (23.8%, 14.4%, 16.4%; P  < .001), whereas no significant differences were found in mortality (5.9%, 8%, 7.4%; P  = .103) or recurrences (3.9%, 3.1%, 2.5%; P  = .546). Not fulfilling OPAT-GAMES criteria was associated with higher risk of readmission (odds ratio [OR], 1.43; 95% CI, 1.03–1.97; P  = .03), whereas cardiac surgery was associated with lower risk (OR, 0.72; 95% CI, 0.53–0.98; P  = .03). Conclusions OPAT-GAMES criteria allow identification of IE patients at higher risk of long-term complications to whom OPAT cannot be safely administered. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

39. Infective Endocarditis in Patients on Chronic Hemodialysis

Author

Pericàs, Juan M., primary, Llopis, Jaume, additional, Jiménez-Exposito, Maria Jesús, additional, Kourany, Wissam M., additional, Almirante, Benito, additional, Carosi, Giampiero, additional, Durante-Mangoni, Emanuele, additional, Fortes, Claudio Querido, additional, Giannitsioti, Efthymia, additional, Lerakis, Stamatios, additional, Montagna-Mella, Rodrigo, additional, Ambrosioni, Juan, additional, Tan, Ru-San, additional, Mestres, Carlos A., additional, Wray, Dannah, additional, Pachirat, Orathai, additional, Moreno, Asuncion, additional, Chu, Vivian H., additional, de Lazzari, Elisa, additional, Fowler, Vance G., additional, Miró, Jose M., additional, Clara, Liliana, additional, Sanchez, Marisa, additional, Casabé, José, additional, Cortes, Claudia, additional, Nacinovich, Francisco, additional, Oses, Pablo Fernandez, additional, Ronderos, Ricardo, additional, Sucari, Adriana, additional, Thierer, Jorge, additional, Altclas, Javier, additional, Kogan, Silvia, additional, Spelman, Denis, additional, Athan, Eugene, additional, Harris, Owen, additional, Kennedy, Karina, additional, Tan, Ren, additional, Gordon, David, additional, Papanicolas, Lito, additional, Korman, Tony, additional, Kotsanas, Despina, additional, Dever, Robyn, additional, Jones, Phillip, additional, Konecny, Pam, additional, Lawrence, Richard, additional, Rees, David, additional, Ryan, Suzanne, additional, Feneley, Michael P., additional, Harkness, John, additional, Post, Jeffrey, additional, Reinbott, Porl, additional, Gattringer, Rainer, additional, Wiesbauer, Franz, additional, Andrade, Adriana Ribas, additional, Passos de Brito, Ana Cláudia, additional, Guimarães, Armenio Costa, additional, Grinberg, Max, additional, Mansur, Alfredo José, additional, Siciliano, Rinaldo Focaccia, additional, Varejao Strabelli, Tania Mara, additional, Campos Vieira, Marcelo Luiz, additional, de Medeiros Tranchesi, Regina Aparecida, additional, Paiva, Marcelo Goulart, additional, de Oliveira Ramos, Auristela, additional, Weksler, Clara, additional, Ferraiuoli, Giovanna, additional, Golebiovski, Wilma, additional, Lamas, Cristiane, additional, Karlowsky, James A., additional, Keynan, Yoav, additional, Morris, Andrew M., additional, Rubinstein, Ethan, additional, Jones, Sandra Braun, additional, Garcia, Patricia, additional, Cereceda, M., additional, Fica, Alberto, additional, Mella, Rodrigo Montagna, additional, Fernandez, Ricardo, additional, Franco, Liliana, additional, Gonzalez, Javier, additional, Jaramillo, Astrid Natalia, additional, Barsic, Bruno, additional, Bukovski, Suzana, additional, Krajinovic, Vladimir, additional, Pangercic, Ana, additional, Rudez, Igor, additional, Vincelj, Josip, additional, Freiberger, Tomas, additional, Pol, Jiri, additional, Zaloudikova, Barbora, additional, Ashour, Zainab, additional, El Kholy, Amani, additional, Mishaal, Marwa, additional, Osama, Dina, additional, Rizk, Hussien, additional, Aissa, Neijla, additional, Alauzet, Corentine, additional, Alla, Francois, additional, Campagnac, CHU Catherine, additional, Doco-Lecompte, Thanh, additional, Selton-Suty, Christine, additional, Casalta, Jean-Paul, additional, Fournier, Pierre-Edouard, additional, Habib, Gilbert, additional, Raoult, Didier, additional, Thuny, Franck, additional, Delahaye, Francois, additional, Delahaye, Armelle, additional, Vandenesch, Francois, additional, Donal, Erwan, additional, Donnio, Pierre Yves, additional, Flecher, Erwan, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Tattevin, Pierre, additional, Chevalier, Florent, additional, Jeu, Antoine, additional, Rémadi, Jean Paul, additional, Rusinaru, Dan, additional, Tribouilloy, Christophe, additional, Bernard, Yvette, additional, Chirouze, Catherine, additional, Hoen, Bruno, additional, Leroy, Joel, additional, Plesiat, Patrick, additional, Naber, Christoph, additional, Neuerburg, Carl, additional, Mazaheri, Bahram, additional, Sophia Athanasia, Carl Neuerburg, additional, Deliolanis, Ioannis, additional, Giamarellou, Helen, additional, Thomas, Tsaganos, additional, Mylona, Elena, additional, Paniara, Olga, additional, Papanicolaou, Konstantinos, additional, Pyros, John, additional, Skoutelis, Athanasios, additional, Papanikolaou, Konstantinos, additional, Sharma, Gautam, additional, Francis, Johnson, additional, Nair, Lathi, additional, Thomas, Vinod, additional, Venugopal, Krishnan, additional, Hannan, Margaret M., additional, Hurley, John P., additional, Wanounou, Maor, additional, Gilon, Dan, additional, Israel, Sarah, additional, Korem, Maya, additional, Strahilevitz, Jacob, additional, Iossa, Domenico, additional, Orlando, Serena, additional, Ursi, Maria Paola, additional, Pafundi, Pia Clara, additional, D’Amico, Fabiana, additional, Bernardo, Mariano, additional, Cuccurullo, Susanna, additional, Dialetto, Giovanni, additional, Covino, Franco Enrico, additional, Manduca, Sabrina, additional, Della Corte, Alessandro, additional, De Feo, Marisa, additional, Tripodi, Marie Françoise, additional, Cecchi, Enrico, additional, De Rosa, Francesco, additional, Forno, Davide, additional, Imazio, Massimo, additional, Trinchero, Rita, additional, Grossi, Paolo, additional, Lattanzio, Mariangela, additional, Toniolo, Antonio, additional, Goglio, Antonio, additional, Raglio, Annibale, additional, Ravasio, Veronica, additional, Rizzi, Marco, additional, Suter, Fredy, additional, Magri, Silvia, additional, Signorini, Liana, additional, Kanafani, Zeina, additional, Kanj, Souha S., additional, Sharif-Yakan, Ahmad, additional, Abidin, Imran, additional, Tamin, Syahidah Syed, additional, Martínez, Eduardo Rivera, additional, Soto Nieto, Gabriel Israel, additional, van der Meer, Jan T.M., additional, Chambers, Stephen, additional, Holland, David, additional, Morris, Arthur, additional, Raymond, Nigel, additional, Read, Kerry, additional, Murdoch, David R., additional, Dragulescu, Stefan, additional, Ionac, Adina, additional, Mornos, Cristian, additional, Butkevich, O.M., additional, Chipigina, Natalia, additional, Kirill, Ozerecky, additional, Vadim, Kulichenko, additional, Vinogradova, Tatiana, additional, Edathodu, Jameela, additional, Halim, Magid, additional, Liew, Yee-Yun, additional, Lejko-Zupanc, Tatjana, additional, Logar, Mateja, additional, Mueller-Premru, Manica, additional, Commerford, Patrick, additional, Commerford, Anita, additional, Deetlefs, Eduan, additional, Hansa, Cass, additional, Ntsekhe, Mpiko, additional, Almela, Manel, additional, Azqueta, Manuel, additional, Brunet, Merce, additional, Castro, Pedro, additional, De Lazzari, Elisa, additional, Falces, Carlos, additional, Fuster, David, additional, Fita, Guillermina, additional, Garcia- de- la- Maria, Cristina, additional, Garcia-Gonzalez, Javier, additional, Gatell, Jose M., additional, Marco, Francesc, additional, Miró, José M., additional, Ortiz, José, additional, Ninot, Salvador, additional, Paré, J. Carlos, additional, Pericas, Juan M., additional, Quintana, Eduard, additional, Ramirez, Jose, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Tellez, Adrian, additional, Tolosana, José M., additional, Vidal, Barbara, additional, Vila, Jordi, additional, Anguera, Ignasi, additional, Font, Bernat, additional, Guma, Joan Raimon, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Garcia Fernández, Miguel Angel, additional, Gonzalez-Ramallo, Victor, additional, Marín, Mercedes, additional, Muñoz, Patricia, additional, Pedromingo, Miguel, additional, Roda, Jorge, additional, Rodríguez-Créixems, Marta, additional, Solis, Jorge, additional, Fernandez-Hidalgo, Nuria, additional, Tornos, Pilar, additional, de Alarcón, Arístides, additional, Parra, Ricardo, additional, Alestig, Eric, additional, Johansson, Magnus, additional, Olaison, Lars, additional, Snygg-Martin, Ulrika, additional, Pachirat, Pimchitra, additional, Pussadhamma, Burabha, additional, Senthong, Vichai, additional, Casey, Anna, additional, Elliott, Tom, additional, Lambert, Peter, additional, Watkin, Richard, additional, Eyton, Christina, additional, Klein, John L., additional, Bradley, Suzanne, additional, Kauffman, Carol, additional, Bedimo, Roger, additional, Corey, G. Ralph, additional, Crowley, Anna Lisa, additional, Douglas, Pamela, additional, Drew, Laura, additional, Holland, Thomas, additional, Lalani, Tahaniyat, additional, Mudrick, Daniel, additional, Samad, Zaniab, additional, Sexton, Daniel, additional, Stryjewski, Martin, additional, Wang, Andrew, additional, Woods, Christopher W., additional, Cantey, Robert, additional, Steed, Lisa, additional, Dickerman, Stuart A., additional, Bonilla, Hector, additional, DiPersio, Joseph, additional, Salstrom, Sara-Jane, additional, Baddley, John, additional, Patel, Mukesh, additional, Peterson, Gail, additional, Stancoven, Amy, additional, Levine, Donald, additional, Riddle, Jonathan, additional, Rybak, Michael, additional, and Cabell, Christopher H., additional

Published
2021
Full Text
View/download PDF

40. COVID-19: from epidemiology to treatment

Author

Pericàs, J M, Hernandez-Meneses, M, Sheahan, T P, Quintana, E, Ambrosioni, J, Sandoval, E, Falces, C, Marcos, M A, Tuset, M, Vilella, A, Moreno, A, Miro, J M, Miró, Jose M, Ambrosioni, Juan, Pericàs, Juan M, Téllez, Adrian, Hernandez-Meneses, Marta, Garcia-Pares, Delia, Moreno, Asunción, de la Maria, Cristina Garcia, Dahl, Anders, Garcia-González, Javier, Cañas-Pacheco, María-Alejandra, Almela, Manel, Casals, Climent, Marco, Francesc, Vila, Jordi, Quintana, Eduard, Sandoval, Elena, Falces, Carlos, Andrea, Ruth, Pereda, Daniel, Azqueta, Manel, Castel, Maria Angeles, Garcia, Ana, Sitges, Marta, Farrero, Marta, Vidal, Barbara, Pérez-Villa, Felix, Pomar, José L, Castella, Manuel, Tolosana, José M, Ortiz, José, Fita, Guillermina, Rovira, Irene, Perissinotti, Andrés, Fuster, David, Ramírez, Jose, Brunet, Mercè, Soy, Dolors, Castro, Pedro, and Llopis, Jaume

Subjects
Male, Clinical Review, medicine.medical_specialty, Prosthesis-Related Infections, Clinical Update, Coronavirus disease 2019 (COVID-19), Operating theatres, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, 030204 cardiovascular system & hematology, Cardiovascular surgeons, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Intensive care, Epidemiology, Pandemic, medicine, Humans, 030212 general & internal medicine, Pandemics, Endocarditis, SARS-CoV-2, business.industry, Prevention, COVID-19, Middle Aged, Prognosis, medicine.disease, Coronavirus, Treatment, Risk factors, Preparedness, Medical emergency, Coronavirus Infections, business, Cardiology and Cardiovascular Medicine
Abstract

The COVID-19 pandemic has greatly impacted the daily clinical practice of cardiologists and cardiovascular surgeons. Preparedness of health workers and health services is crucial to tackle the enormous challenge posed by SARS-CoV-2 in wards, operating theatres, intensive care units, and interventionist laboratories. This Clinical Review provides an overview of COVID-19 and focuses on relevant aspects on prevention and management for specialists within the cardiovascular field.

Published
2020
Full Text
View/download PDF

41. Cloxacillin or fosfomycin plus daptomycin combinations are more active than cloxacillin monotherapy or combined with gentamicin against MSSA in a rabbit model of experimental endocarditis

Author

García de la Mària, Cristina, Gasch, Oriol, Castañeda, Ximena, García González, Javier, Soy, Dolors, Cañas, Maria Alexandra, Ambrosioni, Juan, Almela, Manel, Pericàs, Juan M., Téllez, Adrián, Falces Salvador, Carles, Hernández Meneses, Marta, Sandoval, Elena, Quintana, Eduard, Vidal, Barbara, Tolosana, Jose M., Fuster, David, Llopis, Jaume, Moreno, Asuncion, Marco, Francesc, Miró, Jose M., and Hospital Clínic Endocarditis Study Group

Subjects
Microbiology (medical), Staphylococcus aureus, Microbial Sensitivity Tests, Fosfomycin, Pharmacology, Cloxacillin, Daptomycin, In vivo, polycyclic compounds, Animals, Medicine, Endocarditis, Pharmacology (medical), Medicaments antibacterians, business.industry, Endocarditis, Bacterial, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, Anti-Bacterial Agents, Antibiotic combinations, Infectious Diseases, Antibacterial agents, Rabbit model, Gentamicin, Rabbits, Gentamicins, business, medicine.drug
Abstract

Background In vitro and in vivo activity of daptomycin alone or plus either cloxacillin or fosfomycin compared with cloxacillin alone and cloxacillin plus gentamicin were evaluated in a rabbit model of MSSA experimental endocarditis (EE). Methods Five MSSA strains were used in the in vitro time–kill studies at standard (105–106 cfu/mL) and high (108 cfu/mL) inocula. In the in vivo EE model, the following antibiotic combinations were evaluated: cloxacillin (2 g/4 h) alone or combined with gentamicin (1 mg/kg/8 h) or daptomycin (6 mg/kg once daily); and daptomycin (6 mg/kg/day) alone or combined with fosfomycin (2 g/6 h). Results At standard and high inocula, daptomycin plus fosfomycin or cloxacillin were bactericidal against 4/5 and 5/5 strains, respectively, while cloxacillin plus gentamicin was bactericidal against 3/5 strains at standard inocula but against none at high inocula. Fosfomycin, cloxacillin, gentamicin and daptomycin MIC/MBCs of the MSSA-678 strain used in the EE model were: 8/64, 0.25/0.5, 0.25/0.5 and 1/8 mg/L, respectively. Adding gentamicin to cloxacillin significantly reduced bacterial density in vegetations compared with cloxacillin monotherapy (P = 0.026). Adding fosfomycin or cloxacillin to daptomycin [10/11 (93%) and 8/11 (73%), respectively] significantly improved the efficacy of daptomycin in sterilizing vegetations [0/11 (0%), P Conclusions The addition of cloxacillin or fosfomycin to daptomycin is synergistic and rapidly bactericidal, showing better activity than cloxacillin plus gentamicin for treating MSSA EE, supporting their clinical use.

Published
2020

42. Architectural modulation as a projecting system in Santiago de Benicalaf

Author

Cortés Meseguer, Luis, Pardo Conejero, José, Congost, Josep, Pérez Llopis, Jaume, Cortés Meseguer, Luis, Pardo Conejero, José, Congost, Josep, and Pérez Llopis, Jaume

Abstract

[EN] The current rules of projecting contemporary architecture are different from other historical periods. There are some rules and laws that composes each different styles. The treaty writers recover classical composition with order and balancing geometric figures, especially for façades and doorways, improving the architectural production at that time. The architects of the 17th century knew the treaties and they applied on their buildings, so we can talk about a culture architecture and by analysing their works, it brings us closer to its process. Such is the case of the façade of the church of Santiago de Benicalaf (Valencia) -Spain- in which by following the most relevant Spanish treaties, many of those rules are reflected. This study allows us to get closer to the architect, in addition to establishing the architectural work as an architectural reference within its heritage context., [ES] Bien es sabido que las reglas de proyectar la Arquitectura contemporánea son muy distintas a otros periodos históricos e incluso, entre los distintos estilos existen distintas leyes que las diferencian. Con la aparición de los tratadistas se recuperó la tradición clásica de composición con el orden y figuras geométricas equilibrantes, sobre todo para fachadas y portadas. El usar los conocimientos de los tratados implicaba que los Maestros tenían una formación en Arquitectura y, por lo tanto, se puede hablar de una arquitectura culta y al analizar las obras, nos acerca más a su proceso. Tal es el caso de la fachada de la iglesia de Santiago de Benicalaf (Valencia) -Spain- en el que al seguir los tratados de mayor relevancia, es decir, los conocidos en tierras españolas, se ven reflejadas muchas de esas reglas y que nos permiten acercarnos al artífice, además de asentar la obra arquitectónica como referente arquitectónico dentro de su contexto patrimonial.

Published
2020

43. A Contemporary Picture of Enterococcal Endocarditis

Author

Pericás Pulico, Juan Manuel, Llopis, Jaume, Muñoz, Patricia, Gálvez-Acebal, Juan, Kestler Hernández, Martha, Valerio, Maricela, Hernández-Meneses, Marta, Goenaga Sánchez, Miguel Ángel, Cobo Belaustegui, Manuel, Montejo, Miguel, Ojeda Burgos, Guillermo, Sousa Regueiro, Dolores, Alarcón González, Arístides de, Ramos-Martínez, Antonio, Miró, José María, Pericás Pulico, Juan Manuel, Llopis, Jaume, Muñoz, Patricia, Gálvez-Acebal, Juan, Kestler Hernández, Martha, Valerio, Maricela, Hernández-Meneses, Marta, Goenaga Sánchez, Miguel Ángel, Cobo Belaustegui, Manuel, Montejo, Miguel, Ojeda Burgos, Guillermo, Sousa Regueiro, Dolores, Alarcón González, Arístides de, Ramos-Martínez, Antonio, and Miró, José María

Abstract

[Background] Enterococcal endocarditis (EE) is a growing entity in Western countries. However, quality data from large studies is lacking., [Objectives] The purpose of this study was to describe the characteristics and analyze the prognostic factors of EE in the GAMES cohort., [Methods] This was a post hoc analysis of a prospectively collected cohort of patients from 35 Spanish centers from 2008 to 2016. Characteristics and outcomes of 516 cases of EE were compared with those of 3,308 cases of nonenterococcal endocarditis (NEE). Logistic regression and Cox proportional hazards regression analysis were performed to investigate risk factors for in-hospital and 1-year mortality, as well as relapses., [Results] Patients with EE were significantly older; more frequently presented chronic lung disease, chronic heart failure, prior endocarditis, and degenerative valve disease; and had higher median age-adjusted Charlson score. EE more frequently involved the aortic valve and prosthesis (64.3% vs. 46.7%; p < 0.001; and 35.9% vs. 28.9%; p = 0.002, respectively) but less frequently pacemakers/defibrillators (1.5% vs. 10.5%; p < 0.001), and showed higher rates of acute heart failure (45% vs. 38.3%; p = 0.005). Cardiac surgery was less frequently performed in EE (40.7% vs. 45.9%; p = 0.024). No differences in in-hospital and 1-year mortality were found, whereas relapses were significantly higher in EE (3.5% vs. 1.7%; p = 0.035). Increasing Charlson score, LogEuroSCORE, acute heart failure, septic shock, and paravalvular complications were risk factors for mortality, whereas prior endocarditis was protective and persistent bacteremia constituted the sole risk factor for relapse., [Conclusions] Besides other baseline and clinical differences, EE more frequently affects prosthetic valves and less frequently pacemakers/defibrillators. EE presents higher rates of relapse than NEE.

Published
2020

44. Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs

Author

Pericàs, Juan M., primary, Llopis, Jaume, additional, Athan, Eugene, additional, Hernández-Meneses, Marta, additional, Hannan, Margaret M., additional, Murdoch, David R., additional, Kanafani, Zeina, additional, Freiberger, Tomas, additional, Strahilevitz, Jacob, additional, Fernández-Hidalgo, Nuria, additional, Lamas, Cristiane, additional, Durante-Mangoni, Emanuele, additional, Tattevin, Pierre, additional, Nacinovich, Francisco, additional, Chu, Vivian H., additional, and Miró, José M., additional

Published
2021
Full Text
View/download PDF

46. Resultados contemporáneos de la endocarditis infecciosa activa protésica izquierda operada en la fase activa: Estudio prospectivo de 142 casos

Author

Fernández-Cisneros, Alejandro, primary, Sandoval, Elena, additional, Hernández-Meneses, Marta, additional, Pereda, Daniel, additional, Castellà, Manuel, additional, Ibánez, Cristina, additional, Rovira, Irene, additional, Llopis, Jaume, additional, Miró, José Maria, additional, and Quintana, Eduard, additional

Published
2020
Full Text
View/download PDF

47. Comportamiento de los scores de riesgo e impacto del uso de umbrales arbitrarios de inoperabilidad en la endocarditis valvular izquierda. Estudio prospectivo de 142 pacientes

Author

Fernández-Cisneros, Alejandro, primary, Llopis, Jaume, additional, Hernández-Meneses, Marta, additional, Sandoval, Elena, additional, Pereda, Daniel, additional, Castellà, Manuel, additional, Ambrosioni, Juan, additional, Ibáñez, Cristina, additional, Miró, José Maria, additional, and Quintana, Eduard, additional

Published
2020
Full Text
View/download PDF

48. Prevalencia, características clínicas y pronóstico de pacientes con endocarditis infecciosa e indicación quirúrgica que no son intervenidos: Estudio retrospectivo multicéntrico del área cataluña central (2009-2018)

Author

Calzado, Sonia, primary, Hernández-Meneses, Marta, additional, Llopis, Jaume, additional, Andrés, Marta, additional, Agustí, Carme, additional, Ortiz, María, additional, Tricas, Josep Maria, additional, Quintana, Eduard, additional, Gasch, Oriol, additional, and Miró, Jose Maria, additional

Published
2020
Full Text
View/download PDF

49. Características clínicas, evolutivas y pronóstico de la endocarditis infecciosa en diez centros de cataluña central: Estudio retrospectivo de 910 casos (2009-2018)

Author

Hernández-Meneses, Marta, primary, Isbert, Sonia Calzado, additional, Llopis, Jaume, additional, Palop, Lucía Boix, additional, Ríos, Javier Díez-De Los, additional, Cuquet, Jordi, additional, Cárdenas, Antoni, additional, Ambrosioni, Juan, additional, Gasch, Oriol, additional, and Miró, José María, additional

Published
2020
Full Text
View/download PDF

50. Reply

Author

Pericàs, Juan M., primary, Llopis, Jaume, additional, Ramos-Martínez, Antonio, additional, Muñoz, Patricia, additional, and Miró, José M., additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results