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23 results on '"Llonga, Natalia"'

1. Dissecting the polygenic contribution of attention-deficit/hyperactivity disorder and autism spectrum disorder on school performance by their relationship with educational attainment

Author

Cabana-Domínguez, Judit, Bosch, Rosa, Soler Artigas, María, Alemany, Silvia, Llonga, Natalia, Vilar-Ribó, Laura, Carabí-Gassol, Pau, Arribas, Lorena, Macias-Chimborazo, Valeria, Español-Martín, Gemma, del Castillo, Clara, Martínez, Laura, Pagerols, Mireia, Pagespetit, Èlia, Prat, Raquel, Puigbó, Julia, Ramos-Quiroga, Josep Antoni, Casas, Miquel, and Ribasés, Marta

Published
2024
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3. Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders

Author

Koller, Dora, Mitjans, Marina, Kouakou, Manuela, Friligkou, Eleni, Cabrera-Mendoza, Brenda, Deak, Joseph D., Llonga, Natalia, Pathak, Gita A., Stiltner, Brendan, Løkhammer, Solveig, Levey, Daniel F., Zhou, Hang, Hatoum, Alexander S., Kember, Rachel L., Kranzler, Henry R., Stein, Murray B., Corominas, Roser, Demontis, Ditte, Artigas, María Soler, Ramos-Quiroga, Josep Antoni, Gelernter, Joel, Ribasés, Marta, Cormand, Bru, and Polimanti, Renato

Published
2024
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5. Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants

Author

Alemany, Silvia, Soler-Artigas, María, Cabana-Domínguez, Judit, Fakhreddine, Dana, Llonga, Natalia, Vilar-Ribó, Laura, Rodríguez-Urrutia, Amanda, Palacio, Judit, González-Castro, Ana María, Lobo, Beatriz, Alonso-Cotoner, Carmen, Simrén, Magnus, Santos, Javier, Ramos-Quiroga, Josep Antoni, and Ribasés, Marta

Published
2023
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7. Disentangling heterogeneity in Substance Use Disorders: Insights from Genome-Wide Polygenic Scores

Author

Vilar-Ribo, Laura, primary, Alemany, Silvia, additional, Cabana-Dominguez, Judit, additional, Llonga, Natalia, additional, Arribas, Lorena, additional, Grau-Lopez, Lara, additional, Daigre, Constanza, additional, Cormand, Bru, additional, Fernandez-Castillo, Noelia, additional, Ramos-Quiroga, Josep Antoni, additional, Soler Artigas, Maria, additional, and Ribases, Marta, additional

Published
2023
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8. F54. DISSECTING POLYGENIC RISK FOR NEURODEVELOPMENTAL DISORDERS BY EDUCATIONAL ATTAINMENT AND EXPLORING THEIR RELATIONSHIP WITH SCHOOL PERFORMANCE

Author

Ribasés, Marta, primary, Bosch, Rosa, additional, Alemany, Silvia, additional, Cabana-Domínguez, Judit, additional, Soler, María, additional, Llonga, Natalia, additional, Vilar, Laura, additional, Carabí, Pau, additional, Arribas, Lorena, additional, Español-Martín, Gemma, additional, Pagerols, Mireia, additional, Prat, Raquel, additional, Pagespetit, Elia, additional, Casas, Miquel, additional, and Ramos-Quiroga, Josep Antoni, additional

Published
2023
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9. F58. INDIVIDUAL AND COMBINED EFFECTS OF POLYGENIC AND ENVIRONMENTAL RISK SCORES ON ATTENTION DEFICIT AND HYPERACTIVITY DISORDER MEASURES AMONG SCHOOL CHILDREN

Author

Alemany, Silvia, primary, Soler-Artigas, María, additional, Cabana-Domínguez, Judit, additional, Bosch, Rosa, additional, Vilar-Ribó, Laura, additional, Llonga, Natalia, additional, Carabí, Pau, additional, Ramos-Quiroga, Josep-Antoni, additional, Pagerols, Mireia, additional, Prat, Raquel, additional, Pagespetit, Elia, additional, Puigbo, Julia, additional, Español-Martín, Gemma, additional, Casas, Miquel, additional, and Ribasés, Marta, additional

Published
2023
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10. T12. EXPLORING THE BEHAVIORAL AND EMOTIONAL MANIFESTATION OF POLYGENIC RISK FOR PSYCHIATRIC DISORDERS AMONG SCHOOL CHILDREN

Author

Alemany, Silvia, primary, Soler, María, additional, Cabana-Domínguez, Judit, additional, Bosch, Rosa, additional, Vilar-Ribó, Laura, additional, Llonga, Natalia, additional, Carabí, Pau, additional, Ramos-Quiroga, Josep-Antoni, additional, Pagerols, Mireia, additional, Prat, Raquel, additional, Pagespetit, Elia, additional, Puigbo, Julia, additional, Español-Martín, Gemma, additional, Casas, Miquel, additional, and Ribasés, Marta, additional

Published
2023
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11. Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hits

Author

Alemany, Silvia, primary, Soler-Artigas, Maria, additional, Cabana-Dominguez, Judit, additional, Fakhreddine, Dana Salim, additional, Llonga, Natalia, additional, Vilar-Ribo, Laura, additional, Rodriguez-Urrutia, Amanda, additional, Palacio, Judit, additional, Gonzalez-Castro, Ana Maria, additional, Lobo, Beatriz, additional, Alonso-Cotoner, Carmen, additional, Simren, Magnus, additional, Santos, Javier, additional, Ramos-Quiroga, Josep Antoni, additional, and Ribases, Marta, additional

Published
2023
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13. F1.INTEGRATED ANALYSIS OF DNA METHYLATION AND GENE EXPRESSION IN ATTENTION-DEFICIT/ HYPERACTIVITY DISORDER

Author

Cabana-Domínguez, Judit, primary, Arribas, Lorena, additional, Alemany, Silvia, additional, Vilar-Ribó, Laura, additional, Llonga, Natalia, additional, Fadeuilhe, Christian, additional, Corrales, Montse, additional, Richarte, Vanessa, additional, Ramos-Quiroga, Josep Antoni, additional, Artigas, María Soler, additional, and Ribasés, Marta, additional

Published
2022
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19. TU4. COMPREHENSIVE ANALYSIS OF OMICS DATA IDENTIFIED ADHD RELEVANT GENE NETWORKS

Author

Cabana-Domínguez, Judit, primary, Artigas, María Soler, additional, Arribas, Lorena, additional, Vilar-Ribó, Laura, additional, Alemany, Silvia, additional, Llonga, Natalia, additional, Fadeuilhe, Christian, additional, Corrales, Montse, additional, Richarte, Vanessa, additional, Ramos-Quiroga, Josep Antoni, additional, and Ribases, Marta, additional

Published
2021
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21. Blattella germanica piRNAs in materno-zygotic transition

Author

Montañés, José Carlos, Llonga, Natalia, Bellés, Xavier, Bau, Josep, and Piulachs, Maria-Dolors

Subjects
endocrine system, urogenital system
Abstract

Poster presented at the Eight International Symposium on Molecular Insect Science, held 7-10th July 2019 in Barcelona (Spain)., The Piwi-interacting RNAs (piRNAs) are a small non-coding RNAs involved in the maintenance of genome stability. piRNAs were described as expressed exclusively in germinal cells, but their presence in somatic cells has been taking relevance in the last years. We have identified the Blattella germanica piRNAs from 24 small RNA libraries, corresponding to different developmental stages (Llonga et al 2018 DOI: 10.1002/jez.b.22815). Now we focus on the identification of piRNAs from a maternal origin and the characterization of the piRNAs involved in the transition to the zygotic stage. The role of such piRNAs in the protection of the embryo genome and the relationship with their putative target RNAs (transposable elements and mRNAs) are key to the understanding of the general functions of these regulatory elements but also their particularities in hemimetabolous insects. The 24 small RNA libraries were aligned against the genome with Bowtie and R Statistical Software was used for expression analysis. Finally, ovary and early embryonic piRNA expressions were validated by qRT-PCR. The analysis of B. germanica individual small RNA libraries, corresponding to ovaries from 7-day-old adult females (OvD7), non-fertilized eggs (NFE), the zygote (ED0), and the first day of embryogenesis (ED1), show that piRNAs in these stages agree with the current model of two piRNA biogenesis pathways. The most expressed piRNAs in each library of this transition have been analyzed in order to identify specific functions for each stage. By mapping the sequence to the genome, we have identified the origin of these piRNAs and also a number of potential mRNAs targets.

Published
2019

23. Diversity of piRNA expression patterns during the ontogeny of the German cockroach

Author

Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Generalitat de Catalunya, European Commission, Llonga, Natalia, Ylla, Guillem, Bau, Josep, Bellés, Xavier, Piulachs, Maria-Dolors, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia e Innovación (España), Generalitat de Catalunya, European Commission, Llonga, Natalia, Ylla, Guillem, Bau, Josep, Bellés, Xavier, and Piulachs, Maria-Dolors

Abstract

The Piwi-interacting RNA (piRNA) system is an evolutionarily conserved mechanism involved in the control of transposable elements and maintenance of genomic stability, especially in germ-line cells and in early embryo stages. However, relevant particularities, both in mechanism and function, exist across species among metazoans and even within the insect class. As a member of the scarcely studied hemimetabolan group, Blattella germanica can be a suitable reference model to study insect evolution. We present the results of a stringent process of identification and study of expressed piRNAs for B. germanica across 11 developmental stages, ranging from non-fertilized egg to nymphs and adult female. Our results confirm the dual origin of piRNA in this species, with a majority of them being generated from the primary pathway, and a smaller but highly expressed set of sequences participating in the secondary (“pingpong”) reamplification pathway. An intriguing partial complementarity in expression is observed between the piRNA of the two biogenesis pathways, with those generated in the secondary pathway being quite restricted to early embryo stages. In addition, many piRNAs are exclusively expressed in late embryo and nymphal stages. These observation point at piRNA functions beyond the role of transposon control in early embryogenesis. Our work supports the view of a more complex scenario, with different sets of piRNAs acting in different times and having a range of functions wider than previously thought.

Published
2018

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