Search

Your search keyword '"Lleres, David"' showing total 15 results
Start Over Author "Lleres, David"
15 results on '"Lleres, David"'

4. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington’s disease patients

Author

Quinti, Luisa, Naidu, Sharadha Dayalan, Träger, Ulrike, Chen, Xiqun, Kegel-Gleason, Kimberly, Llères, David, Connolly, Colúm, Chopra, Vanita, Low, Cho, Moniot, Sébastien, Sapp, Ellen, Tousley, Adelaide R., Vodicka, Petr, Van Kanegan, Michael J., Kaltenbach, Linda S., Crawford, Lisa A., Fuszard, Matthew, Higgins, Maureen, Miller, James R. C., Farmer, Ruth E., Potluri, Vijay, Samajdar, Susanta, Meisel, Lisa, Zhang, Ningzhe, Snyder, Andrew, Stein, Ross, Hersch, Steven M., Ellerby, Lisa M., Weerapana, Eranthie, Schwarzschild, Michael A., Steegborn, Clemens, Leavitt, Blair R., Degterev, Alexei, Tabrizi, Sarah J., Lo, Donald C., DiFiglia, Marian, Thompson, Leslie M., Dinkova-Kostova, Albena T., and Kazantsev, Aleksey G.

Published
2017

11. Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells

Author

Leung, Anthony Kar Lun, Gerlich, Daniel, Miller, Gail, Lyon, Carol, Lam, Yun Wah, Lleres, David, Daigle, Nathalie, Zomerdijk, Joost, Ellenberg, Jan, and Lamond, Angus I.

Subjects
Cytology -- Research, Mitosis, Cells, Biological sciences
Abstract

One of the great mysteries of the nucleolus surrounds its disappearance during mitosis and subsequent reassembly at late mitosis. Here, the relative dynamics of nucleolar disassembly and reformation were dissected using quantitative 4D microscopy with fluorescent protein-tagged proteins in human stable cell lines. The data provide a novel insight into the fates of the three distinct nucleolar subcompartments and their associated protein machineries in a single dividing cell. Before the onset of nuclear envelope (NE) breakdown, nucleolar disassembly started with the loss of RNA polymerase I subunits from the fibrillar centers. Dissociation of proteins from the other subcompartments occurred with faster kinetics but commenced later, coincident with the process of NE breakdown. The reformation pathway also follows a reproducible and defined temporal sequence but the order of reassembly is shown not to be dictated by the order in which individual nucleolar components reaccumulate within the nucleus after mitosis.

Published
2004

13. A histone H4K20 methylation-mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

Author

Shoaib, Muhammad, primary, Walter, David, additional, Gillespie, Peter J., additional, Izard, Fanny, additional, Fahrenkrog, Birthe, additional, Lleres, David, additional, Lerdrup, Mads, additional, Johansen, Jens Vilstrup, additional, Hansen, Klaus, additional, Julien, Eric, additional, Blow, J. Julian, additional, and Sørensen, Claus S., additional

Published
2018
Full Text
View/download PDF

15. Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells.

Author

Anthony Kar Lun Leung, Gerlich, Daniel, Miller, Gail, Lyon, Carol, Yun Wah Lam, Lleres, David, Daigle, Nathalie, Zomerdijk, Joost, Ellenberg, Jan, and Lamond, Angus I.

Subjects
*MITOSIS, *CELL division, *NUCLEOLUS, *CELL lines, *RNA polymerases, *FLUORESCENT polymers, *CYTOFLUOROMETRY
Abstract

One of the great mysteries of the nucleolus surrounds its disappearance during mitosis and subsequent reassembly at late mitosis. Here, the relative dynamics of nucleolar disassembly and reformation were dissected using quantitative 4D microscopy with fluorescent protein-tagged proteins in human stable cell lines. The data provide a novel insight into the fates of the three distinct nucleolar subcompartments and their associated protein machineries in a single dividing cell. Before the onset of nuclear envelope (NE) breakdown, nucleolar disassembly started with the loss of RNA polymerase 1 subunits from the fibrillar centers. Dissociation of proteins from the other subcompartments occurred with faster kinetics but commenced later, coincident with the process of NE breakdown. The reformation pathway also follows a reproducible and defined temporal sequence but the order of reassembly is shown not to be dictated by the order in which individual nucleolar components reaccumulate within the nucleus after mitosis. [ABSTRACT FROM AUTHOR]

Published
2004
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results