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1. The significance of metabolic alkalosis on acute decompensated heart failure: the ALCALOTIC study

Author

Trullàs, Joan Carles, Peláez, Ana Isabel, Blázquez, Julio, Sánchez-Biosca, Anna, López-Reborio, Manuel Lorenzo, Salamanca-Bautista, Prado, Fernández-Rodríguez, José María, Vázquez-Ronda, Miguel Ángel, Dávila-Ramos, Melitón Francisco, Mendoza-Ruiz-De-Zuazu, Humberto, Morales-Rull, José Luís, Olmedo-Llanes, Jesús, Llàcer, Pau, and Conde-Martel, Alicia

Published
2024
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3. Combining loop with thiazide diuretics in patients discharged home after a heart failure decompensation: Association with 30-day outcomes

Author

Fuentes, Marta, Davila, Aitor, del Amo, Sonia, Alonso, Héctor, Pérez-Llantada, Enrique, Martín-Sánchez, Francisco Javier, Miró, Òscar, Gil, Víctor, Escoda, Rosa, Sánchez, Carolina, Repullo, Daniel, Masso, Marta, Millán, Javier, Serrano, Leticia, Pavón, José, González, Nayra Cabrera, Rodríguez, Rafael Calvo, Reyes, Juan Antonio Vega, López-Grima, María Luisa, Valero, Amparo, Juan, María Ángeles, Aguirre, Alfons, Masó, Silvia Mínguez, Alonso, María Isabel, Mecina, Ana Belén, Tost, Josep, Ramón, Susana Sánchez, Rodríguez, Virginia Carbajosa, Piñera, Pascual, Nicolás, José Andrés Sánchez, Aragüés, Paula Lázaro, Garate, Raquel Torres, Rodríguez, Esther Álvarez, Arias, Pilar Paz, Alquézar-Arbé, Aitor, Herrera, Sergio, Carrete, Carlos José Romero, Jacob, Javier, Roset, Alex, Cabello, Irene, Haro, Antonio, Richard, Fernando, Fernández, Elisa, Diez, María Pilar López, Puente, Pablo Herrero, Álvarez, Joaquín Vázquez, García, Belén Prieto, Fernández, Alejandra Fernández, Ramos, Belén Álvarez, Miranda, Natalia Fernández, Llorens, Pere, Espinosa, Begoña, Jara, Gema, Felipe, Alba, Andueza, Juan Antonio, Romero, Rodolfo, López, Mariella Luengo, Domínguez, Gema, Ruíz, Martín, Arriaga, Beatriz Amores, Bergua, Beatriz Sierra, Mojarro, Enrique Martín, Jiménez, Lidia Cuevas, Bécquer, Lisette Travería, Burillo, Guillermo, García, Lluís Llauger, Urbano, Carmen Agüera, de los Ángeles, María, de la Torre, González, Jiménez, Carmen Esmeralda Romero, Ferrer, Ester Soy, Múñoz, María Adroher, Garrido, José Manuel, Lucas-Imbernón, Francisco Javier, Gaya, Rut, Bibiano, Carlos, Mir, María, Rodríguez, Beatriz, Martín, Monika Vicente, Adrada, Esther Rodríguez, Domingo, Eva, Carvajal, Marianela Guzmán, Fortuny, María José, García, Yelenis Gómez, de las Nieves Segura Coronill, Verónica, Esquivias, Marco Antonio, García, Rocío Moyano, Rodríguez, Pablo, Noceda, José, Blasco, Santiago Harris, Romero, Marta, Lorenzo, Miguel, Núñez, Gonzalo, de la Espriella, Rafael, Villar, Sandra, Santas, Enrique, Miñana, Gema, Bodí, Vicent, Sanchis, Juan, Núñez, Julio, Bautista, Prado Salamanca, Hueso, Rocío Ruiz, Domingo, Soraya, Núñez, Mª Victoria, Olmedo, Jesús, Vázquez, Carmen, López, Juan Bosco, Peinado, Alejandro, Montes, Juan Antonio, Díez-Manglano, Jesús, Rodés, Pablo Martínez, Garcés, Vanesa, Rubio, Jorge, Rodríguez, José M Fernández, Curto, Adrián Argüelles, Murphy, Orla Torrallardona, Manso, Meritxell Gavà, Martel, Alicia Conde, García, José Mª, González, Sonia, Dávila, Melitón F, Hernández, Rubén, Gudiño, Diego José, Mendoza, Humberto, Carrera, Margarita, Trullàs, Joan Carles, Epelde, Francisco, Biosca, Anna Sánchez, Becerra, Raquel, Gil, Mercè, Massi, Paulina Ivanova, Chivite, David, Formiga, Francesc, Núñez, Raquel, Pacho, Cristina, Contra, Anna, Ceresuela, Luis, Morales, José Luís, Pla, Xavi, López, Gabriel, Blázquez, Julio, Reboiro, Manuel Lorenzo López, Castro, José López, Asenjo, María, de Peralta, Paula, Llàcer, Pau, Manzano, Luis, Ortega, Raúl Antonio Ruiz, Vázquez, Miguel Ángel, Soler, Llanos, Mesado, Daniel, Casado, Jesús, Abad, Daniel, Ballesta, Ana Isabel Peláez, Rodríguez, Elena Morcillo, Lopez-Ayala, Pedro, Llauger, Lluís, Mollar, Anna, Garcés-Horna, Vanesa, Martínez-Nadal, Gemma, and Mueller, Christian

Published
2024
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4. Consensus on the approach to hydrosaline overload in acute heart failure. SEMI/SEC/S.E.N. recommendations

Author

Llàcer, Pau, Romero, Gregorio, Trullàs, Joan Carles, de la Espriella, Rafael, Cobo, Marta, Quiroga, Borja, Casado, Jesús, Slon-Roblero, María F., Morales-Rull, José Luis, Morgado, José Ignacio, Ortiz, Alberto, Formiga, Francesc, Melendo-Viu, María, de Sequera, Patricia, Recio, Alejandro, Díez, Javier, Manzano, Luis, and Núñez, Julio

Published
2024
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5. Consenso sobre el abordaje de la sobrecarga hidrosalina en insuficiencia cardiaca aguda. Recomendaciones SEMI/SEC/S.E.N.

Author

Llàcer, Pau, Romero, Gregorio, Trullàs, Joan Carles, de la Espriella, Rafael, Cobo, Marta, Quiroga, Borja, Casado, Jesús, Slon-Roblero, María F., Morales-Rull, José Luis, Morgado, José Ignacio, Ortiz, Alberto, Formiga, Francesc, Melendo-Viu, María, de Sequera, Patricia, Recio, Alejandro, Díez, Javier, Manzano, Luis, and Núñez, Julio

Published
2024
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9. Prevalence and clinical profile of kidney disease in patients with chronic heart failure. Insights from the Spanish cardiorenal registry

Author

Cobo Marcos, Marta, de la Espriella, Rafael, Gayán Ordás, Jara, Llàcer, Pau, Pomares, Antonia, Fort, Aleix, Ponz de Antonio, Inés, Méndez, Ana, Blázquez-Bermejo, Zorba, Caravaca Pérez, Pedro, Rubio Gracia, Jorge, Recio-Mayoral, Alejandro, Zegrí, Isabel, García Pinilla, José Manuel, Montero Hernández, Esther, Castro, Almudena, Soler, María José, Górriz, José Luis, Bascompte Claret, Ramón, Fluvià-Brugués, Paula, Manzano, Luis, and Núñez, Julio

Published
2024
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10. Prevalencia y perfil clínico de la enfermedad renal en pacientes con insuficiencia cardiaca crónica. Datos del Registro cardiorrenal español

Author

Cobo Marcos, Marta, de la Espriella, Rafael, Gayán Ordás, Jara, Llàcer, Pau, Pomares, Antonia, Fort, Aleix, Ponz de Antonio, Inés, Méndez, Ana, Blázquez-Bermejo, Zorba, Caravaca Pérez, Pedro, Rubio Gracia, Jorge, Recio-Mayoral, Alejandro, Zegrí, Isabel, García Pinilla, José Manuel, Montero Hernández, Esther, Castro, Almudena, Soler, María José, Górriz, José Luis, Bascompte Claret, Ramón, Fluvià-Brugués, Paula, Manzano, Luis, and Núñez, Julio

Published
2024
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16. Optimal carbohydrate antigen 125 cutpoint for identifying low-risk patients after admission for acute heart failure

Author

Núñez, Julio, Bayés-Genís, Antoni, Revuelta-López, Elena, Miñana, Gema, Santas, Enrique, ter Maaten, Jozine M., de la Espriella, Rafael, Carratalá, Arturo, Lorenzo, Miguel, Palau, Patricia, Llàcer, Pau, Valle, Alfonso, Bodi, Vicent, Núñez, Eduardo, Lupón, Josep, Lang, Chim, Ng, Leong L., Metra, Marco, Sanchis, Juan, and Voors, Adriaan A.

Published
2022
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17. Punto de corte óptimo del antígeno carbohidrato 125 para la identificación de pacientes con bajo riesgo tras un ingreso por insuficiencia cardiaca aguda

Author

Núñez, Julio, Bayés-Genís, Antoni, Revuelta-López, Elena, Miñana, Gema, Santas, Enrique, ter Maaten, Jozine M., de la Espriella, Rafael, Carratalá, Arturo, Lorenzo, Miguel, Palau, Patricia, Llàcer, Pau, Valle, Alfonso, Bodi, Vicent, Núñez, Eduardo, Lupón, Josep, Lang, Chim, Ng, Leong L., Metra, Marco, Sanchis, Juan, and Voors, Adriaan A.

Published
2022
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18. Prognostic Impact of Statins in Heart Failure with Preserved Ejection Fraction.

Author

Ortega-Hernández, Samanta, González-Sosa, Sonia, Conde-Martel, Alicia, Trullàs, Joan Carles, Llàcer, Pau, Pérez-Silvestre, José, Arévalo-Lorido, José Carlos, Casado, Jesús, Formiga, Francesc, Manzano, Luis, Lorenzo-Villalba, Noel, and Montero-Pérez-Barquero, Manuel

Subjects
HEART failure, VASCULAR diseases, ATRIAL fibrillation, HEART diseases, VENTRICULAR ejection fraction, STATINS (Cardiovascular agents)
Abstract

Background: Heart failure (HF) with preserved ejection fraction (pEF) has lacked effective treatments for reducing mortality. However, previous studies have found an association between statin use and decreased mortality in patients with HFpEF. The aim of this study was to analyse whether statin therapy is associated with a reduction in mortality in these patients and whether the effect differs according to the presence or absence of ischaemic heart disease (IHD). Methods: We analysed data from the National Registry of Heart Failure, a prospective study that included patients admitted for HF in Internal Medicine units nationwide. Patients with HFpEF were classified according to the use of statins, and the differences between the two groups were analysed. A multivariable analysis was performed using Cox regression to assess factors independently related to mortality. Results: A total of 2788 patients with HFpEF were included; 63% of them were women with a mean age of 80.1 (±7.8) years. The statin-treated group (40.2%) was younger, with better functional status, and had a more common diagnosis of vascular disease and lower frequency of atrial fibrillation. The most frequent aetiology of HF in both groups was the hypertensive one. Nevertheless, ischaemic HF was more common in those who received statins (24.8% vs. 9.6%; p < 0.001). Multivariable analysis showed lower mortality at the 1-year follow-up in statin-treated patients (OR: 0.74; 95%CI: 0.61–0.89; p = 0.002). This association was observed in patients without IHD (p < 0.001) but not in those with IHD (p = 0.11). Conclusions: Statins are associated with a decrease in total mortality in patients with HFpEF. This benefit occurs mainly in those without IHD. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Efficacy and safety of hypertonic saline therapy in ambulatory patients with heart failure: The SALT‐HF trial.

Author

Cobo Marcos, Marta, de la Espriella, Rafael, Comín‐Colet, Josep, Zegrí‐Reiriz, Isabel, Rubio Gracia, Jorge, Morales‐Rull, Jose Luis, Llàcer, Pau, Díez‐Villanueva, Pablo, Jiménez‐Marrero, Santiago, de Juan Bagudá, Javier, Ortiz Cortés, Carolina, Restrepo‐Córdoba, Maria Alejandra, Goirigolzarri‐Artaza, Josebe, García‐Pinilla, Jose Manuel, Barrios, Elvira, del Prado Díaz, Susana, Montero Hernández, Esther, Sanchez‐Marteles, Marta, and Núñez, Julio

Subjects
HYPERTONIC saline solutions, VENA cava inferior, HEART failure patients, INTRAVENOUS therapy, KIDNEY physiology
Abstract

Aims: Combination of hypertonic saline solution (HSS) with intravenous loop diuretics has been suggested to improve diuretic response in patients hospitalized for heart failure (HF). The efficacy and safety of this approach in the ambulatory setting remain unexplored. Methods and results: In this multicentre, double‐blind, randomized study, we allocated ambulatory patients with worsening heart failure (WHF) to a 1‐h infusion of intravenous furosemide (ivFurosemide)‐HSS versus ivFurosemide. The primary endpoint was the volume of diuresis at 3 h. Secondary endpoints included 3‐h natriuresis and weight variation, 7‐day congestion data, kidney function and electrolytes, and 30‐day clinical events. Overall, 167 participants (median age: 81 years, 30.5% female) were randomized across 13 sites between December 2020 and March 2023. There were no differences in 3‐h diuresis between treatments (ivFurosemide‐HSS: 1099 ml vs. ivFurosemide: 1103 ml, p = 0.963), 3‐h natriuresis (∆ +2.642 mEq/L, p = 0.559), or 3‐h weight (∆ +0.012 kg, p = 0.920). Patients in the ivFurosemide‐HSS arm experienced significant weight decrease at 7 days (Δ −0.586 kg, p = 0.048). There were no between‐treatment differences in clinical congestion score, biomarkers, inferior vena cava diameter, or the presence of lung ultrasound B‐lines. At 30 days, 26.5% of the patients in the ivFurosemide‐HSS group versus 33.3% in the ivFurosemide group experienced WHF (hazard ratio 0.76, p = 0.330). The incidence of death from any cause or HF hospitalization was 6% of patients in the ivFurosemide‐HSS group and 8.3% of patients in the ivFurosemide group (hazard ratio 0.69, p = 0.521). The incidence of worsening kidney function or metabolic derangements was not significantly different in the two arms. Conclusions: A single infusion of ivFurosemide‐HSS did not improve 3‐h diuresis or congestion parameters in patients with ambulatory WHF. This therapy showed an appropriate safety profile. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Recomendaciones para desarrollar Modelos Asistenciales de atención al paciente con Insuficiencia Cardiaca (Proyecto MAIC): Estudio Delphi

Author

Comín-Colet, Josep, Alcober, Laia, Calero-Molina, Esther, Cobo, Marta, Corbella, Xavier, Cruzado, Concepción, Pinilla, José Manuel García, Gijón-Conde, Teresa, González-Franco, Álvaro, Llácer, Pau, Méndez-Bailón, Manuel, Muñiz, Javier, Núñez, Julio, Saturnino, Maria Teresa San, Muñoz, Cristina, Ibarrola, Cristina, Comin-Colet, J., Calero-Molina, E., Corbella, X., Muñiz, J., San Saturnino, M., and Ibarrola, C.

Published
2022
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22. Factores clave para modelos de atención a la insuficiencia cardiaca. Una visión integradora y multidisciplinar

Author

Comín-Colet, Josep, Alcober, Laia, Calero-Molina, Esther, Cobo, Marta, Corbella, Xavier, Cruzado, Concepción, Gijón-Conde, Teresa, González-Franco, Álvaro, Ibarrola Guillén, Cristina, Llácer, Pau, Méndez-Bailón, Manuel, Muñiz, Javier, Núñez, Julio, San Saturnino, María Teresa, Matali, Arantxa, and García-Pinilla, José M.

Published
2022
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24. Congestion as a crucial factor determining albuminuria in in patients with cardiorenal disease

Author

Llàcer, Pau, primary, Marcos, Marta Cobo, additional, de la Espriella, Rafael, additional, Ordás, Jara Gayán, additional, Zegri, Isabel, additional, Fort, Aleix, additional, Chavarri, Adriana Rodríguez, additional, Méndez, Ana, additional, Blázquez, Zorba, additional, Pérez, Pedro Caravaca, additional, Gracia, Jorge Rubio, additional, Fernández, Cristina, additional, Recio-Mayoral, Alejandro, additional, Pomares, Antonia, additional, Pinilla, Jose Manuel García, additional, López-Ibor, Jorge Vazquez, additional, Castro, Almudena, additional, Soler, Maria Jose, additional, Górriz, Jose Luis, additional, Claret, Ramón Bascompte, additional, Fluvià, Paula, additional, Manzano, Luis, additional, and Núñez, Julio, additional

Published
2024
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26. Early urinary sodium trajectory and risk of adverse outcomes in acute heart failure and renal dysfunction

Author

de la Espriella, Rafael, Núñez, Eduardo, Llàcer, Pau, García-Blas, Sergio, Ventura, Silvia, Núñez, José María, Sánchez, Ruth, Fácila, Lorenzo, Vaquer, Juana María, Bodí, Vicent, Santas, Enrique, Miñana, Gema, Mollar, Anna, Núñez, Gonzalo, Chorro, Francisco J., Górriz, José L., Sanchis, Juan, Bayés-Genis, Antoni, and Núñez, Julio

Published
2021
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27. Trayectoria precoz del sodio urinario y riesgo de eventos adversos en insuficiencia cardiaca aguda y disfunción renal

Author

de la Espriella, Rafael, Núñez, Eduardo, Llàcer, Pau, García-Blas, Sergio, Ventura, Silvia, Núñez, José María, Sánchez, Ruth, Fácila, Lorenzo, Vaquer, Juana María, Bodí, Vicent, Santas, Enrique, Miñana, Gema, Mollar, Anna, Núñez, Gonzalo, Chorro, Francisco J., Górriz, José L., Sanchis, Juan, Bayés-Genis, Antoni, and Núñez, Julio

Published
2021
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32. CA125-Guided Diuretic Treatment Versus Usual Care in Patients With Acute Heart Failure and Renal Dysfunction

Author

Núñez, Julio, Llàcer, Pau, García-Blas, Sergio, Bonanad, Clara, Ventura, Silvia, Núñez, José María, Sánchez, Ruth, Fácila, Lorenzo, de la Espriella, Rafael, Vaquer, Juana María, Cordero, Alberto, Roqué, Mercè, Chamorro, Carlos, Bodi, Vicent, Valero, Ernesto, Santas, Enrique, Moreno, María del Carmen, Miñana, Gema, Carratalá, Arturo, Rodríguez, Enrique, Mollar, Anna, Palau, Patricia, Bosch, María José, Bertomeu-González, Vicente, Lupón, Josep, Navarro, Jorge, Chorro, Francisco J., Górriz, Jose L., Sanchis, Juan, Voors, Adriaan A., and Bayés-Genís, Antoni

Published
2020
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35. De novo acute heart failure: Clinical features and one-year mortality in the Spanish nationwide Registry of Acute Heart Failure

Author

Anarte, L., Aramburu, O., Arévalo-Lorido, J.C., Carrascosa, S., Carrera, M., Cepeda, J.M., Cerqueiro, J.M., Conde-Martel, A., Dávila, M.F., Díez-Manglano, J., Epelde, F., Formiga, F., Franco, J., García-Escrivá, D., González Franco, A., Llàcer, P., López-Castellanos, G., Manzano, L., Montero-Pérez-Barquero, M., Muela, A., Pérez-Silvestre, J., Quesada, M.A., Roca, B., Ruíz-Ortega, R., Satué, J.A., Soler-Rangel, L., Trullàs, J.C., Franco, Jonathan, Formiga, Francesc, Corbella, Xavier, Conde-Martel, Alicia, Llácer, Pau, Álvarez Rocha, Pablo, Ormaechea Gorricho, Gabriela, Satué, José, Soler Rangel, Llanos, Manzano, Luis, and Montero-Pérez-Barquero, Manuel

Published
2019
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36. Insuficiencia cardiaca aguda de novo: características clínicas y mortalidad al año en el Registro Español de Insuficiencia Cardiaca Aguda

Author

Anarte, L., Aramburu, O., Arévalo-Lorido, J.C., Carrascosa, S., Carrera, M., Cepeda, J.M., Cerqueiro, J.M., Conde-Martel, A., Dávila, M.F., Díez-Manglano, J., Epelde, F., Formiga, F., Franco, J., García-Escrivá, D., González Franco, A., Llàcer, P., López-Castellanos, G., Manzano, L., Montero-Pérez-Barquero, M., Muela, A., Pérez-Silvestre, J., Quesada, M.A., Roca, B., Ruíz-Ortega, R., Satué, J.A., Soler-Rangel, L., Trullàs, J.C., Franco, Jonathan, Formiga, Francesc, Corbella, Xavier, Conde-Martel, Alicia, Llácer, Pau, Álvarez Rocha, Pablo, Ormaechea Gorricho, Gabriela, Satué, José, Soler Rangel, Llanos, Manzano, Luis, and Montero-Pérez-Barquero, Manuel

Published
2019
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38. Congestion as a crucial factor determining albuminuria in patients with cardiorenal disease.

Author

Llàcer, Pau, Marcos, Marta Cobo, de la Espriella, Rafael, Ordás, Jara Gayán, Zegri, Isabel, Fort, Aleix, Chavarri, Adriana Rodríguez, Méndez, Ana, Blázquez, Zorba, Pérez, Pedro Caravaca, Gracia, Jorge Rubio, Fernández, Cristina, Recio-Mayoral, Alejandro, Pomares, Antonia, Pinilla, Jose Manuel García, López-Ibor, Jorge Vazquez, Castro, Almudena, Soler, Maria Jose, Górriz, Jose Luis, and Claret, Ramón Bascompte

Subjects
*HEART failure, *ALBUMINURIA, *DIABETIC nephropathies, *CONGESTIVE heart failure, *SYSTOLIC blood pressure, *CHRONIC kidney failure, *VENTRICULAR ejection fraction
Abstract

Background Albuminuria could potentially emerge as a novel marker of congestion in acute heart failure. However, the current evidence linking albuminuria and congestion in patients with congestive heart failure (CHF) remains somewhat scarce. This study aimed to evaluate the prevalence of albuminuria in a cohort of patients with CHF, identify the independent factors associated with albuminuria and analyse the correlation with different congestion parameters. Methods This is a subanalysis of the Spanish Cardiorenal Registry, in which we enrolled 864 outpatients with heart failure and a value of urinary albumin:creatinine ratio (UACR) at the first visit. Results The median age was 74 years, 549 (63.5%) were male and 438 (50.7%) had a reduced left ventricular ejection fraction. A total of 350 patients (40.5%) had albuminuria. Among these patients, 386 (33.1%) had a UACR of 30–300 mg/g and 64 (7.4%) had a UACR >300 mg/g. In order of importance, the independent variables associated with higher UACR were estimated glomerular filtration rate determined by the Chronic Kidney Disease Epidemiology Collaboration equation (R 2 = 57.6%), systolic blood pressure (R 2 = 21.1%), previous furosemide equivalent dose (FED; R 2 = 7.5%), antigen carbohydrate 125 (CA125; R 2 = 6.1%), diabetes mellitus (R 2 = 5.6%) and oedema (R 2 = 1.9%). The combined influence of oedema, elevated CA125 levels and the FED accounted for 15.5% of the model's variability. Conclusions In patients with chronic stable heart failure, the prevalence of albuminuria is high. The risk factors of albuminuria in this population are chronic kidney disease and hypertension. Congestion parameters are also associated with increased albuminuria. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Loop diuretic down‐titration at discharge in patients hospitalized for acute heart failure.

Author

Croset, François, Llàcer, Pau, Núñez, Julio, Campos, Jorge, García, Marina, Pérez, Alberto, Fernández, Cristina, Fabregate, Martín, López, Genoveva, Tello, Susana, Fernández, José María, Ruiz, Raúl, and Manzano, Luis

Subjects
HEART failure, HOSPITAL admission & discharge, DIURETICS, PROPORTIONAL hazards models, HYPERVOLEMIA
Abstract

Aims: The current literature provides limited guidance on the best diuretic strategy post‐hospitalization for acute heart failure (AHF). It is postulated that the efficacy and safety of the outpatient diuretic regimen may be significantly influenced by the degree of fluid overload (FO) encountered during hospitalization. We hypothesize that in patients with more pronounced FO, reducing their regular oral diuretic dosage might be associated with an elevated risk of unfavourable clinical outcomes. Methods and results: It was a retrospective observational study of 410 patients hospitalized for AHF in which the dose of furosemide at admission and discharge was collected. Patients were categorized across diuretic dose status into two groups: (i) the down‐titration group and (ii) the stable/up‐titration group. FO status was evaluated by a clinical congestion score and circulating biomarkers. The endpoint of interest was the composite of time to all‐cause death and/or heart failure readmission. A multivariable Cox proportional hazard regression model was constructed to analyse the endpoints. The median age was 86 (78–92) years, 256 (62%) were women, and 80% had heart failure with preserved ejection fraction. After multivariate adjustment, the down‐titration furosemide equivalent dose remained not associated with the risk of the combined endpoint in the whole sample (hazard ratio 1.34, 95% confidence interval 0.86–2.06, P = 0.184). The risk of the combination of death and/or worsening heart failure associated with the diuretic strategy at discharge was significantly influenced by FO status, including clinical congestion scores and circulating proxies of FO like BNP and cancer antigen 125. Conclusions: In patients hospitalized for AHF, furosemide down‐titration does not imply an increased risk of mortality and/or heart failure readmission. However, FO status modifies the effect of down‐titration on the outcome. In patients with severe congestion or residual congestion at discharge, down‐titration was associated with an increased risk of mortality and/or heart failure readmission. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Improvement in left atrial strain following ferric carboxymaltose in heart failure: an analysis of the Myocardial‐IRON trial.

Author

Santas, Enrique, del Canto, Irene, Cardells, Ingrid, Miñana, Gema, Llàcer, Pau, Almenar, Luis, Fácila, Lorenzo, Maceira, Alicia M., Sanchis, Juan, and Núñez, Julio

Subjects
LEFT heart atrium, FAILURE analysis, HEART failure, VENTRICULAR ejection fraction, IRON deficiency
Abstract

Aims: Iron deficiency (ID) is associated with an impaired cardiac function and remodelling in heart failure (HF). Treatment with ferric carboxymaltose (FCM) has been showed recently to improve biventricular systolic function and ventricular strain parameters in patients with HF with reduced ejection fraction and ID, but there is no evidence on the benefit of FCM on the left atrium (LA). In this study, we aimed to evaluate the effect of FCM on LA longitudinal strain (LA‐LS). Methods and results: This is a post hoc subanalysis of a double‐blind, placebo‐controlled, randomized clinical trial that enrolled 53 ambulatory patients with HF, left ventricular ejection fraction (LVEF) < 50%, and ID [Myocardial‐IRON trial (NCT03398681)], treated with FCM or placebo. Cardiac magnetic resonance‐featured tracking (CMR‐FT) strain changes were evaluated before and 7 and 30 days after randomization using linear mixed regression analysis. The median age of the sample was 68 years (interquartile range: 64–76), and 20 (69%) were men. Mean ± standard deviation of LVEF was 39 ± 11%, and most (97%) were in stable New York Heart Association class II. At baseline, mean LA‐LS was −8.9 ± 3.5%. At 30 days, and compared with placebo, LA‐LS significantly improved in those allocated to FCM treatment arm (LA‐LS = −12.0 ± 0.5 and −8.5 ± 0.6, respectively; − ∆ 3.55%, P < 0.001). Conclusions: In patients with stable HF, LVEF < 50%, and ID, treatment with FCM was associated with short‐term improvements in LA‐LS assessed by CMR‐FT. Future works should assess the potential benefit of iron repletion on LA function. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Prognosis of acute heart failure in patients followed up in nursing homes in Spain: Results from the RICA registry

Author

Méndez-Bailon, Manuel, primary, Lorenzo-Villalba, Noel, additional, Epelde-Gonzálo, Francisco, additional, Llàcer, Pau, additional, Conde-Martel, Alicia, additional, Manzano-Espinosa, Luis, additional, Arévalo-Lorido, José Carlos, additional, Trullás, Joan Carles, additional, Casado-Cerrada, Jesús, additional, and Montero-Pérez-Barquero, Manuel, additional

Published
2023
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45. Prevalencia y perfil clínico de la enfermedad renal en pacientes con insuficiencia cardiaca crónica. Datos del Registro cardiorrenal español

Author

Marcos, Marta Cobo, primary, Espriella, Rafael de la, additional, Ordás, Jara Gayán, additional, Llàcer, Pau, additional, Pomares, Antonia, additional, Fort, Aleix, additional, Ponz de Antonio, Inés, additional, Méndez, Ana, additional, Blázquez-Bermejo, Zorba, additional, Pérez, Pedro Caravaca, additional, Gracia, Jorge Rubio, additional, Recio-Mayoral, Alejandro, additional, Zegrí, Isabel, additional, Manuel García Pinilla, José, additional, Hernández, Esther Montero, additional, Castro, Almudena, additional, Soler, María José, additional, Luis Górriz, José, additional, Claret, Ramón Bascompte, additional, Fluvià-Brugués, Paula, additional, Manzano, Luis, additional, and Núñez, Julio, additional

Published
2023
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46. Diuretic Strategies in Acute Heart Failure and Renal Dysfunction: Conventional vs Carbohydrate Antigen 125-guided Strategy. Clinical Trial Design

Author

García-Blas, Sergio, Bonanad, Clara, Llàcer, Pau, Ventura, Silvia, Núñez, José María, Sánchez, Ruth, Chamorro, Carlos, Fácila, Lorenzo, de la Espriella, Rafael, Vaquer, Juana María, Cordero, Alberto, Roqué, Mercè, Ortiz, Víctor, Racugno, Paolo, Bodí, Vicent, Valero, Ernesto, Santas, Enrique, Moreno, María del Carmen, Miñana, Gema, Carratalá, Arturo, Bondanza, Lourdes, Payá, Ana, Cardells, Ingrid, Heredia, Raquel, Pellicer, Mauricio, Valls, Guillermo, Palau, Patricia, Bosch, María José, Raso, Rafael, Sánchez, Andrés, Bertomeu-González, Vicente, Bertomeu-Martínez, Vicente, Montagud-Balaguer, Vicente, Albiach-Montañana, Cristina, Pendás-Meneau, Jezabel, Marcaida, Goitzane, Cervantes-García, Sonia, San Antonio, Rodolfo, de Mingo, Elisabet, Chorro, Francisco J., Sanchis, Juan, and Núñez, Julio

Published
2017
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47. Estrategias diuréticas en insuficiencia cardiaca aguda con disfunción renal: terapia convencional frente a guiada por el antígeno carbohidrato 125. Diseño de ensayo clínico

Author

García-Blas, Sergio, Bonanad, Clara, Llàcer, Pau, Ventura, Silvia, Núñez, José María, Sánchez, Ruth, Chamorro, Carlos, Fácila, Lorenzo, de la Espriella, Rafael, Vaquer, Juana María, Cordero, Alberto, Roqué, Mercè, Ortiz, Víctor, Racugno, Paolo, Bodí, Vicent, Valero, Ernesto, Santas, Enrique, Moreno, María del Carmen, Miñana, Gema, Carratalá, Arturo, Bondanza, Lourdes, Payá, Ana, Cardells, Ingrid, Heredia, Raquel, Pellicer, Mauricio, Valls, Guillermo, Palau, Patricia, Bosch, María José, Raso, Rafael, Sánchez, Andrés, Bertomeu-González, Vicente, Bertomeu-Martínez, Vicente, Montagud-Balaguer, Vicente, Albiach-Montañana, Cristina, Pendás-Meneau, Jezabel, Marcaida, Goitzane, Cervantes-García, Sonia, San Antonio, Rodolfo, de Mingo, Elisabet, Chorro, Francisco J., Sanchis, Juan, and Núñez, Julio

Published
2017
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49. Prognostic significance of plasma chloride in elderly patients hospitalized for acute heart failure

Author

Llàcer, Pau, primary, Croset, François, additional, Núñez, Julio, additional, Campos, Jorge, additional, Fernández, Cristina, additional, Fabregate, Martín, additional, Del Hoyo, Beatriz, additional, Ruiz, Raúl, additional, López, Genoveva, additional, Tello, Susana, additional, Lorenzo, Ana, additional, Fernández, José María, additional, and Manzano, Luis, additional

Published
2023
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50. Usefulness of urinary potassium to creatinine ratio to predict diuretic response in patients with acute heart failure and preserved ejection fraction

Author

Llàcer, Pau, primary, Núñez, Julio, additional, Croset, François, additional, García, Marina, additional, Fabregate, Martín, additional, Ruiz, Raúl, additional, López, Genoveva, additional, Fernández, Cristina, additional, Del Hoyo, Beatriz, additional, Campos, Jorge, additional, Gomis, Antonio, additional, and Manzano, Luis, additional

Published
2023
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