Background: Pay-for-performance reimbursement models are becoming increasingly popular, but the implementation of a routine patient-reported outcome (PRO) collection system places additional burden on both the patient and the provider. The Patient-Reported Outcomes Measurement Information System (PROMIS) was developed in an effort to make PRO collection more practical and efficient, but providers may be reluctant to embrace a transition to a PROMIS-based clinical outcome registry., Hypothesis: PROMIS can be successfully incorporated into daily clinical practice, with an overall patient compliance rate of 80%., Study Design: Cross-sectional study; Level of evidence, 3., Methods: As part of routine practice, all patients presenting to a single surgeon's sports medicine clinic for an appointment were asked to complete a series of PROMIS computerized adaptive tests (CATs), including PROMIS Physical Function, Physical Function-Upper Extremity, Pain Interference, and Depression subscales. Overall compliance was calculated by dividing the number of survey sets completed by the number of eligible clinic visits. Compliance rates were further assessed by patient age, type of clinic visit, and location of injury. Costs associated with this system of routine PRO collection were categorized as start-up or maintenance costs., Results: From August 7, 2017, to December 8, 2017, there were 581 patients (1109 clinic encounters) who met inclusion criteria for the study. Of the 1109 clinic encounters, there was an overall compliance rate of 91.3% (1013/1109 visits during which the patient completed the entire PROMIS survey set). Overall, the full survey set consisted of a mean 15.3 questions and took a mean of 2.6 minutes to complete. Patients who were aged ≥62 years had a significantly lower compliance rate (81.8%; P < .0001) than each of the younger patient quartiles. When analyzing patients by the most common locations of injury (elbow, shoulder, hip, knee), the compliance rate for completing PROMIS was significantly higher for the hip than for the shoulder (95.1% vs 88.9%, respectively; P = .02). The cost of establishing a PROMIS-based registry using our project design and workflow was estimated at $2045, whereas the monthly maintenance cost was $1000., Conclusion: The routine electronic collection of PROMIS scores in the ambulatory orthopaedic clinic resulted in a compliance rate of over 90%, although older patients were generally less compliant than younger patients. Our system of data collection is practical and efficient in a high-volume orthopaedic clinic and places minimal financial burden on the provider., Competing Interests: One or more of the authors has declared the following potential conflict of interest or source of funding: E.C.M. receives publishing royalties from Springer, has received educational support from Pinnacle, and has received hospitality payments from Smith & Nephew and Stryker. N.N.V. receives royalties from Smith & Nephew and Vindico Medical Education (Orthopedics Hyperguide); is a paid consultant for Arthrex, Minivasive, Smith & Nephew, and OrthoSpace; has received educational support from Medacta; has stock/stock options in CyMedica, Minivasive, and Omeros; receives research support from Arthrex, Smith & Nephew, Athletico, ConMed Linvatec, Miomed, Mitek, Arthrosurface, DJ Orthopaedics, and Ossur; and has received hospitality payments from Smith & Nephew, Pacira Pharmaceuticals, Arthrex, and Medwest Associates. S.M. is a paid consultant for DePuy and Exactech and has received hospitality payments from DePuy Synthes, Zimmer Biomet, Exactech, Tornier, Conventus Orthopaedics, Exactech, and Arthrex. V.M. has received hospitality payments from Stryker, Pinnacle, and Smith & Nephew and has received educational support from Arthrex and Pinnacle. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.