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A ternary nanocomposite photoelectrode composed of CdS, PANI, and BiVO4 was successfully designed by combining cyclic voltammetry with electrochemical deposition and high-temperature calcination.

Establishing documented evidence that provides a high degree of assurance that a specific wet granulation process for manufacturing rosuvastatin calcium tablets 40 mg will consistently produce a product meeting its pre-determined specifications and quality attributes. It mainly involves the steps to be followed to evaluate and qualify the acceptability of the wet granulation manufacturing process of rosuvastatin calcium tablets 40 mg. The process is limited to the three batches manufactured of specific batch size with specified equipment and control parameters for rosuvastatin calcium tablets 40 mg. The results suggest providing documentary evidence that all the manufactured rosuvastatin calcium tablets were evaluated as per specifications. The steps involved such as Blend uniformity results between 90% and 110%, compression assay results between 90% and 110% were found within acceptable limits. Other tests related to compression such as hardness, thickness, disintegration, dissolution and for coatings such as weight gain, dissolution was found within acceptable limit. The design was chosen for fasting and fed study and showed bioequivalence with RLD (Codine®), with 90% CI values found to be between 80% and 125%.

The design and construction of a photoelectrochemical (PEC) sensor with excellent photoelectric properties and good photoelectrocatalysis activity is significant for the effective detection of analytes. In this paper, based on a two-step anodic oxidation method and successive ionic layer adsorption (SILAR) method, a TiO2 nanotube array (TNT) photoelectrochemical sensor modified with BiOBr nanosheets was constructed and applied for the detection of H2O2 for the first time. The photocurrent of the photoelectrochemical sensor increases with the increase of the H2O2 concentration under the irradiation of an 8 W UV lamp. Excellent linearity was obtained in the concentration range from 10 nM to 100 μM with a low detection limit of 5 nM (S/N = 3). This excellent photoelectrochemical performance is due to the formation of a p-n heterojunction between BiOBr and TiO2 nanotube arrays, which provides efficient separation of charge carriers and accelerates electron transport. Moreover, it is applied to detect H2O2 in milk samples and it showed a good recovery result ranging from 95.73% to 105.65%, which provides a promising new strategy for the detection of H2O2.

OBJECTIVE: Anthracosis is defined as deposition of black pigments in the bronchial mucosa or lung parenchyma. The aim of this study was to investigate the clinical features of patients with coexisting anthracosis and interstitial lung diseases (ILDs). METHODS: A total of 335 ILDs patients who underwent bronchoscopy at the affiliated hospital of Qingdao University were included in our study. We enrolled 71 patients who diagnosed with anthracosis by bronchoscopy. The clinical presentations, radiographic features, and bronchoscopic findings of the patients were reviewed. RESULTS: Compared with the non-anthracosis group, biomass exposure (48, 67.6% vs. 153, 53.9%, p=0.041), the median pressure of carbon dioxide before six-minute test (42.00 mmHg vs. 40.00 mmHg, P=0.001), the mean peak expiratory flow (115.21 ±23.55 %predicted vs. 104.20±26.17%pre-dicted, P=0.048), the mean level of triglyceride (1.79±1.27 mmol/L vs. 1.51 ±0.74 mmol/L, P=0.034) were significantly increased and the mean oxygen saturation after six-minute test (95.49 ±2.72% vs. 96.56 ±1.27%, P=0.028), the mean cardiac ejection fraction (61.22±2.07% vs.62.08±2.89%, P=0.019) were significantly decreased in the anthracosis group. However, we didn’t find significant difference between the two groups in lymph node calcification (p=0.620) and lymphadenectasis (p=0.440). CONCLUSIONS: Biomass smoke is a risk factor for anthracosis. Anthracosis produce a bad effect on the oxygenation, cardiac function and lipid metabolism in ILDs patients. The ILDs patients should decrease the exposure of biomass.

The design and construction of a photoelectrochemical (PEC) sensor with excellent photoelectric properties and good photoelectrocatalysis activity is significant for the effective detection of analytes. In this paper, based on a two-step anodic oxidation method and successive ionic layer adsorption (SILAR) method, a TiO2 nanotube array (TNT) photoelectrochemical sensor modified with BiOBr nanosheets was constructed and applied for the detection of H2O2 for the first time. The photocurrent of the photoelectrochemical sensor increases with the increase of the H2O2 concentration under the irradiation of an 8 W UV lamp. Excellent linearity was obtained in the concentration range from 10 nM to 100 μM with a low detection limit of 5 nM (S/N = 3). This excellent photoelectrochemical performance is due to the formation of a p-n heterojunction between BiOBr and TiO2 nanotube arrays, which provides efficient separation of charge carriers and accelerates electron transport. Moreover, it is applied to detect H2O2 in milk samples and it showed a good recovery result ranging from 95.73% to 105.65%, which provides a promising new strategy for the detection of H2O2.

Ternary nanocomposite photoelectrodes composed of Ag nanoparticles, reduced graphene oxide (RGO), and TiO2 nanotube arrays (TNTs) were successfully designed and achieved by a combining technique of cyclic voltammetry and anodic oxidation. Herein, the obtained RGO/Ag-TNTs composites were employed for photoelectrochemical (PEC) monitoring platform of hydrogen peroxide (H2O2) for the first time. Compared to pure TNTs, Ag-TNTs, and RGO-TNTs, the ternary RGO/Ag-TNTs nanocomposites with appropriate loading amount of RGO and Ag show much higher PEC activity, which were contributed to the synergistic effect resulting from the effective incorporation of Ag nanoparticles and RGO onto the TNTs to accelerate the electron transfer, increase the charge carrier density and prolong the electron lifetime demonstrated by electrochemical impedance spectroscopy (EIS), Mott-Schottky (M-S) measurements and open circuit voltage decay (OCVD) measurement. Under the optimal experimental conditions, the as-prepared PEC sensors exhibited an extremely wide dynamic range from 10−7 nM to 10 mM, and in the range of 0.1–10 mM with higher sensitivity and a detection limit of 20 μM. Moreover, the PEC sensors displayed good reproducibility, long-term stability, and selectivity toward the determination of H2O2. These excellent results make the as-developed ternary RGO/Ag-TNTs nanocomposites a promising candidate in PEC detection H2O2.

Abnormal visual experience can affect the brain structure and function. Visual functional performances of high myopia (HM) individuals were observed to be abnormal in contrast to emmetropics, even with a corrected visual acuity. Attention deficits and brain morphological changes have been revealed in the HM, but it is unknown whether there are functional connectivity (FC) alterations. The current study combined the resting-state functional connectivity density (FCD) mapping and seed-based correlation analysis to investigate FC alterations in the brain of HM. In our results, the HM exhibited decreased short- and long-range FCD in the posterior cingulate cortex/precuneus and decreased long-range FCD in the inferior temporal gyrus, supramarginal gyrus and rostrolateral prefrontal cortex. Specially, long-range FCD in the rostrolateral prefrontal cortex showed a significant positive correlation with the uncorrected visual acuity in the HM. Moreover, the HM showed significantly decreased FC not only between the supramarginal gyrus and rostrolateral prefrontal cortex, but also between networks they belong to, the ventral attention and frontoparietal control networks. These results provide evidence for the FC changes in the HM and may help to understand the attention deficits in myopes.

Amblyopia is a neurological disorder of vision that follows abnormal binocular interaction or visual deprivation during early life. Previous studies have reported multiple functional or structural cortical alterations. Although white matter was also studied, it still cannot be clarified clearly which fasciculus was affected by amblyopia. In the present study, tract-based spatial statistics analysis was applied to diffusion tensor imaging (DTI) to investigate potential diffusion changes of neural tracts in anisometropic amblyopia. Fractional anisotropy (FA) value was calculated and compared between 20 amblyopic children and 18 healthy age-matched controls. In contrast to the controls, significant decreases in FA values were found in right optic radiation (OR), left inferior longitudinal fasciculus/inferior fronto-occipital fasciculus (ILF/IFO) and right superior longitudinal fasciculus (SLF) in the amblyopia. Furthermore, FA values of these identified tracts showed positive correlation with visual acuity. It can be inferred that abnormal visual input not only hinders OR from well developed, but also impairs fasciculi associated with dorsal and ventral visual pathways, which may be responsible for the amblyopic deficiency in object discrimination and stereopsis. Increased FA was detected in right posterior part of corpus callosum (CC) with a medium effect size, which may be due to compensation effect. DTI with subsequent measurement of FA is a useful tool for investigating neuronal tract involvement in amblyopia.