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1,591 results on '"Livingston, A. E."'

1. Canadian Naval Tribute Project: Commander Roland Bourke VC, DSO, RCNVR

Author

Livingston, Sean E.

Subjects
Venture capital, Venture capital, History, Military and naval science
Abstract

In command of ML 276, Bourke follows two cruisers, HMS Brilliant and Sirius, on route to the port of Ostend. Unbeknownst to him, the ships have fallen prey to an [...]

Published
2024

2. Canadian Naval Tribute Project: Captain Adelaide Helen Grant Sinclair OC, OBE, WRCNS

Author

Livingston, Sean E.

Subjects
Canada. Royal Canadian Navy, Women executives -- Appreciation, History, Military and naval science, United Nations
Abstract

Provided Exceptional Leadership in organizing the Women's Royal Canadian Naval Service during the Second World War.' Sinclair was exactly the sort of person Canada needed for the job--ambitious, motivated, and [...]

Published
2023

4. Three institutional pathways to envision the future of the IPCC

Author

Asayama, Shinichiro, De Pryck, Kari, Beck, Silke, Cointe, Béatrice, Edwards, Paul N., Guillemot, Hélène, Gustafsson, Karin M., Hartz, Friederike, Hughes, Hannah, Lahn, Bård, Leclerc, Olivier, Lidskog, Rolf, Livingston, Jasmine E., Lorenzoni, Irene, MacDonald, Joanna Petrasek, Mahony, Martin, Miguel, Jean Carlos Hochsprung, Monteiro, Marko, O’Reilly, Jessica, Pearce, Warren, Petersen, Arthur, Siebenhüner, Bernd, Skodvin, Tora, Standring, Adam, Sundqvist, Göran, Taddei, Renzo, van Bavel, Bianca, Vardy, Mark, Yamineva, Yulia, and Hulme, Mike

Published
2023
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12. Combination of polymeric micelle formulation of TGFβ receptor inhibitors and paclitaxel produces consistent response across different mouse models of Triple‐negative breast cancer

Author

Vinod, Natasha, primary, Hwang, Duhyeong, additional, Fussell, Sloane Christian, additional, Owens, Tyler Cannon, additional, Tofade, Olaoluwa Christopher, additional, Benefield, Thad S., additional, Copling, Sage, additional, Ramsey, Jacob D., additional, Rädler, Patrick D., additional, Atkins, Hannah M., additional, Livingston, Eric E., additional, Ezzell, J. Ashley, additional, Sokolsky‐Papkov, Marina, additional, Yuan, Hong, additional, Perou, Charles M., additional, and Kabanov, Alexander V., additional

Published
2024
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17. Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor.

Author

Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, and Traynor, John R

Subjects
Humans, Methadone, Urea, Biotin, Loperamide, Thiophenes, Streptavidin, Receptors, Opioid, mu, Solutions, Ligands, Sensitivity and Specificity, Interferometry, Biosensing Techniques, Allosteric Regulation, Allosteric Site, Protein Binding, Small Molecule Libraries, Single-Domain Antibodies, GPCR, biochemistry, chemical biology, drug discovery, efficacy, ligand, molecular biophysics, mouse, opioid, structural biology, Receptors, Opioid, mu, Biochemistry and Cell Biology
Abstract

The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects. Here, we present a direct way to quantify the efficacy of ligands by measuring the binding of a R*-specific biosensor to purified receptor employing interferometry. As an example, we use the mu-opioid receptor (µ-OR), a prototypic class A GPCR, and its active state sensor, nanobody-39 (Nb39). We demonstrate that ligands vary in their ability to recruit Nb39 to µ-OR and describe methadone, loperamide, and PZM21 as ligands that support unique R* conformation(s) of µ-OR. We further show that positive allosteric modulators of µ-OR promote formation of R* in addition to enhancing promotion by orthosteric agonists. Finally, we demonstrate that the technique can be utilized with heterotrimeric G protein. The method is cell-free, signal transduction-independent and is generally applicable to GPCRs.

Published
2018

19. Climate change adaptation through an integrative lens in Aotearoa New Zealand.

Author

Lawrence, Judy, Wreford, Anita, Blackett, Paula, Hall, David, Woodward, Alistair, Awatere, Shaun, Livingston, Mary E., Macinnis-Ng, Cate, Walker, Susan, Fountain, Joanna, Costello, Mark John, Ausseil, Anne-Gaelle E., Watt, Michael S., Dean, Sam M., Cradock-Henry, Nicholas A., Zammit, Christian, and Milfont, Taciano L.

Subjects
CLIMATE change adaptation, GREENHOUSE gas mitigation, PHYSIOLOGICAL adaptation
Abstract

Climate change is being felt across all human and natural systems in Aotearoa New Zealand and is projected to worsen this decade as impacts compound and cascade through natural system and sectoral dependencies. The effectiveness of adaptation is constrained by how fast greenhouse gas emissions are reduced globally, the pace of change, the frequency and progression of impacts, and the capacity of our natural, societal and political systems to respond. We explore how these systems and sectors interact with existing and projected climate change stressors by categorising climate change impacts (Trends and Events) and consequential thresholds (Thresholds), and by grouping systems and sectors by types (Typologies). This approach has identified commonalities and differences between the typologies which are illustrated with examples. Critical constraints and opportunities for adaptation have been identified to guide sector adaptation decision-making and for ongoing adaptation progress and effectiveness monitoring. Constraints are found across all sectors, and opportunities exist to address them through modelling and projections, monitoring frameworks, decision tools and measures, governance coordination and integration of the Māori worldview of the relationship between humans and nature. However, limits to adaptation exist and will increase over time unless all sectors and all nations urgently reduce their emissions. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Structural insights into µ-opioid receptor activation

Author

Huang, Weijiao, Manglik, Aashish, Venkatakrishnan, AJ, Laeremans, Toon, Feinberg, Evan N, Sanborn, Adrian L, Kato, Hideaki E, Livingston, Kathryn E, Thorsen, Thor S, Kling, Ralf C, Granier, Sébastien, Gmeiner, Peter, Husbands, Stephen M, Traynor, John R, Weis, William I, Steyaert, Jan, Dror, Ron O, and Kobilka, Brian K

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Chemical Sciences, Pharmacology and Pharmaceutical Sciences, Biotechnology, Neurosciences, Generic health relevance, Allosteric Regulation, Animals, Binding Sites, Crystallography, X-Ray, Heterotrimeric GTP-Binding Proteins, Mice, Models, Molecular, Molecular Dynamics Simulation, Morphinans, Protein Stability, Protein Structure, Tertiary, Pyrroles, Receptor, Muscarinic M2, Receptors, Adrenergic, beta-2, Receptors, Opioid, mu, Single-Chain Antibodies, Structure-Activity Relationship, General Science & Technology
Abstract

Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for μOR activation, here we report a 2.1 Å X-ray crystal structure of the murine μOR bound to the morphinan agonist BU72 and a G protein mimetic camelid antibody fragment. The BU72-stabilized changes in the μOR binding pocket are subtle and differ from those observed for agonist-bound structures of the β2-adrenergic receptor (β2AR) and the M2 muscarinic receptor. Comparison with active β2AR reveals a common rearrangement in the packing of three conserved amino acids in the core of the μOR, and molecular dynamics simulations illustrate how the ligand-binding pocket is conformationally linked to this conserved triad. Additionally, an extensive polar network between the ligand-binding pocket and the cytoplasmic domains appears to play a similar role in signal propagation for all three G-protein-coupled receptors.

Published
2015

26. Optimizing Stakeholder AI: the Role of Educator.

Author

Livingston, Roland E. and Maes, Jeanne D.

Subjects
STAKEHOLDERS, ARTIFICIAL intelligence in industry, READING comprehension, EMPLOYMENT, TECHNICAL education
Abstract

It is evident that artificial intelligence (AI) is here to stay. As more and more industries and professions are embracing it, executives are calling upon educational institutions to play a vital role in preparing workers across all organizational lines to navigate the oncoming tsunami of AI and utilize it effectively on their jobs. This paper presents a current overview of the AI landscape and discusses specific ways that educational institutions can support executives across a wide range of fields to help potential employees be productive from the outset of employment. It addresses the value of communication skills, including clear and concise writing, critical reading and thinking, and comprehensive interpersonal skills. A key role for educational institutions to play is to help professions and industries recognize and address the unintentional bias that seeps through when using AI. [ABSTRACT FROM AUTHOR]

Published
2024

27. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures

Author

Benjamin, Daniel K., Jr, Berezny, Katherine Y., Wolkowiez, P. Michael Cohen, Laughon, Matthew M., Paul, Ian M., Smith, Michael J., van den Anker, John, Wade, Kelly, Siegel, David, Taylor-Zapata, Perdita, Zajicek, Anne, Ren, Zhaoxia, Tsilou, Ekaterini, Pagan, Alice, Anand, Ravinder, Clemons, Traci, Simone, Gina, Howard, Lee, Weigel, Jaylene, Darden Saad, Nancy, Shakhnovich, Valentina, Smith, P. Brian, Guptill, Jeffrey T., James, Laura P., Collier, David N., Wu, Huali, Livingston, Chad E., Zhao, Jian, and Kearns, Gregory L.

Published
2018
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28. Climate change adaptation through an integrative lens in Aotearoa New Zealand

Author

Lawrence, Judy, primary, Wreford, Anita, additional, Blackett, Paula, additional, Hall, David, additional, Woodward, Alistair, additional, Awatere, Shaun, additional, Livingston, Mary E., additional, Macinnis-Ng, Cate, additional, Walker, Susan, additional, Fountain, Joanna, additional, Costello, Mark John, additional, Ausseil, Anne-Gaelle E., additional, Watt, Michael S., additional, Dean, Sam M., additional, Cradock-Henry, Nicholas A., additional, Zammit, Christian, additional, and Milfont, Taciano L., additional

Published
2023
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32. Association of Opioid Administration During General Anesthesia and Survival for Severely Injured Trauma Patients: A Preplanned Secondary Analysis of the PROPPR Study

Author

Levy, Dominique T., primary, Livingston, Colleen E., additional, Saroukhani, Sepideh, additional, Fox, Erin E., additional, Wade, Charles E., additional, Holcomb, John B., additional, Gumbert, Sam D., additional, Galvagno, Samuel M., additional, Kaslow, Olga Y., additional, Pittet, Jean-Francois, additional, and Pivalizza, Evan G., additional

Published
2023
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36. Author Correction: Structural insights into μ-opioid receptor activation

Author

Huang, Weijiao, Manglik, Aashish, Venkatakrishnan, A. J., Laeremans, Toon, Feinberg, Evan N., Sanborn, Adrian L., Kato, Hideaki E., Livingston, Kathryn E., Thorsen, Thor S., Kling, Ralf C., Granier, Sébastien, Gmeiner, Peter, Husbands, Stephen M., Traynor, John R., Weis, William I., Steyaert, Jan, Dror, Ron O., and Kobilka, Brian K.

Published
2020
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42. IRS Intermediate Sanctions: How They Will Impact Colleges and Universities.

Author

Cerny, Milton and Livingston, Catherine E.

Abstract

Colleges and universities are generally subject to new penalty excise taxes under the Internal Revenue Service (IRS) code on charitable and educational organizations. The law and proposed regulations are explained, with specific attention to how the rules apply to colleges and universities and how these institutions can best protect themselves from triggering liability for the taxes. (Author/MSE)

Published
1999

47. HMCS Oakville: baptism by fire, Part II

Author

Livingston, Sean E.

Subjects
Canada. Royal Canadian Navy -- Powers and duties, Corvettes (Warships) -- History, Canadian history -- Military aspects, History, Military and naval science
Abstract

HMCS Oakville fought in WWII's Battle of the Atlantic, and was one of the few Canadian corvettes to sink a U-boat The book Oakville's Flower sets the scene of naval [...]

Published
2015

48. HMCS Oakville: baptism by fire

Author

Livingston, Sean E.

Subjects
History, Military and naval science
Abstract

HMCS Oakville fought in WWII's Battle of the Atlantic, and was one of the few Canadian corvettes to sink a U-boat The book Oakville's Flower sets the scene of naval [...]

Published
2014

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