1. Probiotics and prebiotics to combat enteric infections and HIV in the developing world: a consensus report
- Author
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Pinaki Panigrahi, Andi Shane, Balakrishnan S. Ramakrishna, Maria Alejandra Diaz, Richard Guerrant, Livia Trois, Daniel Merenstein, Rober Kemperman, Marko Kerac, Remco Kort, Gregor Reid, Susanna Cunningham-Rundles, Ruben Hummelen, Marc Monachese, Nasia Safdar, Molecular Cell Physiology, AIMMS, Centraal Instituut voor Voedingsonderzoek TNO, and Public Health
- Subjects
Diarrhea ,Male ,Microbiology (medical) ,Resource disadvantaged ,medicine.medical_specialty ,medicine.medical_treatment ,Developing country ,HIV Infections ,Microbiology ,law.invention ,Probiotic ,SDG 17 - Partnerships for the Goals ,Life ,SDG 3 - Good Health and Well-being ,Acquired immunodeficiency syndrome (AIDS) ,law ,medicine ,Humans ,Oral rehydration therapy ,Child ,Preschool ,Intensive care medicine ,Nutrition Biology ,Developing Countries ,Congresses ,Randomized Controlled Trials as Topic ,business.industry ,Probiotics ,Gastroenterology ,Infant ,medicine.disease ,Biotechnology ,Clinical trial ,Roadmap ,MSB - Microbiology and Systems Biology ,Prebiotics ,Infectious Diseases ,Infectious disease (medical specialty) ,Child, Preschool ,HIV/AIDS ,Female ,EELS - Earth, Environmental and Life Sciences ,Bacterial vaginosis ,medicine.symptom ,business - Abstract
Infectious disease in the developing world continues to represent one of the greatest challenges facing humanity. Every year over a million children suffer and die from the sequela of enteric infections, and in 2008 was estimated almost 2.7 million (UNAIDS 2009 update) adults and children became infected with human immunodeficiency virus (HIV). While oral rehydration therapy for diarrhea and antiretrovirals (ARV) for HIV are critical, there is a place for adjunctive therapies to improve quality of life. The importance of the human microbiota in retaining health is now recognized, as is the concept of replenishing beneficial microbes through probiotic treatments. Studies have shown that probiotics can reduce the duration of diarrhea, improve gut barrier function, help prevent bacterial vaginosis (BV) and enhance immunity even in HIV-infected subjects. However, many issues remain before the extent of probiotic benefits can be verified, and their application to the developing world realized. This consensus report outlines the potential probiotic, and to a lesser extent prebiotic, applications in resource disadvantaged settings, and recommends steps that could bring tangible relief to millions of people. The challenges to both efficacy and effectiveness studies in these settings include a lack of infrastructure and funding for scientists, students and research projects in developing countries; making available clinically proven probiotic and prebiotic products at affordable prices; and undertaking appropriately designed clinical trials. We present a roadmap on how efficacy studies may be conducted in a resource disadvantaged setting among persons with chronic diarrhea and HIV. These examples and the translation of efficacy into effectiveness are described. © 2011 Landes Bioscience. Chemicals/CAS: glutamine, 56-85-9, 6899-04-3; retinol, 68-26-8, 82445-97-4; zinc, 14378-32-6, 7440-66-6
- Published
- 2011