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2. Beating Versus Arrested Heart Isolated Tricuspid Valve Surgery: Long-term Outcomes

Author

Russo, M, Di Mauro, M, Saitto, G, Lio, A, Berretta, P, Taramasso, M, Scrofani, R, Della Corte, A, Sponga, S, Greco, E, Saccocci, M, Calafiore, A, Bianchi, G, Leviner, D, Biondi, A, Della Ratta, E, Livi, U, Sharoni, E, Werner, P, De Vincentiis, C, Di Eusanio, M, Kocher, A, Antona, C, Miraldi, F, Troise, G, Solinas, M, Maisano, F, Laufer, G, Musumeci, F, Andreas, M, Russo M., Di Mauro M., Saitto G., Lio A., Berretta P., Taramasso M., Scrofani R., Della Corte A., Sponga S., Greco E., Saccocci M., Calafiore A., Bianchi G., Leviner D. B., Biondi A., Della Ratta E., Livi U., Sharoni E., Werner P., De Vincentiis C., Di Eusanio M., Kocher A., Antona C., Miraldi F., Troise G., Solinas M., Maisano F., Laufer G., Musumeci F., Andreas M., Russo, M, Di Mauro, M, Saitto, G, Lio, A, Berretta, P, Taramasso, M, Scrofani, R, Della Corte, A, Sponga, S, Greco, E, Saccocci, M, Calafiore, A, Bianchi, G, Leviner, D, Biondi, A, Della Ratta, E, Livi, U, Sharoni, E, Werner, P, De Vincentiis, C, Di Eusanio, M, Kocher, A, Antona, C, Miraldi, F, Troise, G, Solinas, M, Maisano, F, Laufer, G, Musumeci, F, Andreas, M, Russo M., Di Mauro M., Saitto G., Lio A., Berretta P., Taramasso M., Scrofani R., Della Corte A., Sponga S., Greco E., Saccocci M., Calafiore A., Bianchi G., Leviner D. B., Biondi A., Della Ratta E., Livi U., Sharoni E., Werner P., De Vincentiis C., Di Eusanio M., Kocher A., Antona C., Miraldi F., Troise G., Solinas M., Maisano F., Laufer G., Musumeci F., and Andreas M.

Abstract

Background: Isolated tricuspid valve (TV) surgery is a rare procedure generally considered at high risk for perioperative mortality and poor long-term outcomes. Surgical treatment can be performed with either an arrested heart (AH) or beating heart (BH) technique. The aim of this study was to compare the outcomes of isolated tricuspid surgery with 2 different approaches. Methods: The Surgical-Tricuspid Study is a multicenter international retrospective study enrolling adult patients who underwent isolated TV procedures (n = 406; age 56 ± 16 years; 56% female) at 13 international sites. The AH and BH strategies were performed in 253 and 153 patients, respectively. Propensity score-matched analysis was used to compare groups. Results: After matching, 129 pairs were obtained and analyzed. The 30-day mortality rate was 6.2% versus 5.0% in the AH and BH groups, respectively (P = .9). The rates of acute renal failure requiring replacement therapy (10% versus 3%; P = .02) and stroke (1.6% versus 0%; P = .08) were numerically higher in the AH group. The 6-year survival rate was 67% ± 6% versus 78% ± 5% in the AH and BH groups, respectively (P = .18), whereas freedom from cardiac death was 75% ± 5% versus 84% ± 4% (P = .21). The 6-year composite cardiac end point of cardiac death and reoperation rate was 60% ± 9% versus 86% ± 5% (P = .024) comparing AH-TV replacement and BH-TV repair groups. Conclusions: Isolated TV surgery performed with a BH strategy is a safe option and resulted in a trend of increased long-term survival and freedom from reoperation compared with the standard AH technique. Patients undergoing BH valve repair had the best long-term outcome.

Published
2022

7. OC09 CLINICAL AND HEMODYNAMIC OUTCOMES AFTER AORTIC VALVE REPLACEMENT WITH RAPID-DEPLOYMENT BIOPROSTHESES: RESULTS FROM AN ITALIAN NATIONAL REGISTRY

Author

D’Onofrio, A., Tessari, C., Filippini, C., Diena, M., Solinas, M., Alamanni, F., Massetti, M., Livi, U., Di Eusanio, M., Mignosa, C., Russo, C., Rinaldi, M., Di Bartolomeo, R., Luzi, G., Antona, C., De Paulis, R., Salvador, L., Maselli, D., Portoghese, M., Alfieri, O., De Filippo, C.M., Bortolotti, U., Musumeci, F., and Gerosa, G.

Published
2018
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8. OC21 EARLY OUTCOMES OF MINIMALLY INVASIVE AORTIC VALVE REPLACEMENT WITH RAPID DEPLOYMENT BIOPROSTHESES: INSIGHTS FROM AN ITALIAN NATIONAL REGISTRY.

Author

Tessari, C., D’Onofrio, A., Diena, M., Solinas, M., Alamanni, F., Massetti, M., Livi, U., Di Eusanio, M., Mignosa, C., Russo, C., Rinaldi, M., Di Bartolomeo, R., Luzi, G., Antona, C., De Paulis, R., Salvador, L., Maselli, D., Portoghese, M., Alfieri, O., De Filippo, C.M., Bortolotti, U., Musumeci, F., and Gerosa, G.

Published
2018
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9. OC69 SURGERY FOR BENTALL ENDOCARDITIS: SHORT AND LONG-TERM OUTCOME FROM A MULTI-CENTRE REGISTRY

Author

Sponga, S., Di Mauro, M., Pacini, D., Murara, G., Di Bartolomeo, R., Cappabianca, G., Beghi, C., Weltert, L., De Paulis, R., De Vincentiis, C., Biondi, A., Santini, F., Salsano, A., Salvador, L., Picichè, M., Mariscalco, G., Maselli, D., Rinaldi, M., Mancuso, S., Scrofani, R., Cagnoni, G., Antona, C., Dato, G.M.A., Centofani, P., De Bonis, M., Pozzoli, A., Cugola, D., Galletti, L., Villa, E., Dossena, Y., Troise, G., Barili, F., Paparella, D., Margari, V., Lorusso, R., Parolari, A., and Livi, U.

Published
2018
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10. OC71 SURGICAL TREATMENT FOR ISOLATED TRICUSPID VALVE INFECTIVE ENDOCARDITIS. 25-YEAR RESULTS

Author

Di Mauro, M., Dato, G. Actis, Barili, F., Corte, A. Della, Ratta, E. Della, Cugola, D., Galletti, L., Centofanti, P., Santini, F., Salsano, A., Rinaldi, M., Mancuso, S., Cappabianca, G., Beghi, C., De Vincentiis, C., Biondi, A., Livi, U., Sponga, S., Pacini, D., Murara, G., Di Bortalomeo, R., Scrofani, R., Cagnoni, G., Antona, C., Nicolini, F., Benassi, F., De Bonis, M., Pozzoli, A., Casali, G., Scrascia, G., Bortolotti, U., Falcetta, G., Musumeci, F., Gherli, R., Vizzardi, E., Salvador, L., Piccichè, M., Paparella, D., Margari, V., Troise, G., Villa, E., Dossena, Y., Lucarelli, C., Onorati, F., Faggian, G., Mariscalco, G., Maselli, D., Foschi, M., Parolari, A., and Lorusso, R.

Published
2018
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15. ECMO for COVID-19 patients in Europe and Israel

Author

Lorusso, R, Combes, A, Coco, V, De Piero, M, Belohlavek, J, Delnoij, T, van der Horst, I, Miranda, D, van der Linden, M, van der Heijden, J, Scholten, E, van Belle-van Haren, N, Lagrand, W, de Jong, S, Candura, D, Maas, J, van den Berg, M, Malfertheiner, M, Dreier, E, Mueller, T, Boeken, U, Akhyari, P, Lichtenberg, A, Saeed, D, Thiele, H, Baumgaertel, M, Schmitto, J, Mariani, S, Thielmann, M, Brenner, T, Benk, C, Czerny, M, Kalbhenn, J, Maier, S, Schibilsky, D, Staudacher, D, Henn, P, Iuliu, T, Muellenbach, R, Reyher, C, Rolfes, C, Zacharowski, K, Lotz, G, Sonntagbauer, M, Kersten, A, Karagiannidis, C, Schafer, S, Fichte, J, Hopf, H, Samalavicius, R, Lorini, L, Ghitti, D, Grazioli, L, Loforte, A, Baiocchi, M, Checco, E, Pacini, D, Meani, P, Cappai, A, Russo, C, Bottiroli, M, Mondino, M, Ranucci, M, Fina, D, Ballotta, A, Scandroglio, A, Zangrillo, A, Pieri, M, Nardelli, P, Fominskiy, E, Landoni, G, Fanelli, V, Brazzi, L, Montrucchio, G, Sales, G, Simonetti, U, Urbino, R, Livigni, S, Degani, A, Raffa, G, Pilato, M, Martucci, G, Arcadipane, A, Chiarini, G, Latronico, N, Cattaneo, S, Puglia, C, Reina, G, Sponga, S, Livi, U, Foti, G, Giani, M, Rona, R, Avalli, L, Bombino, M, Costa, M, Carozza, R, Donati, A, Piciche, M, Favaro, A, Salvador, L, Danzi, V, Zanin, A, Condello, I, Fiore, F, Moscarelli, M, Nasso, G, Speziale, G, Sandrelli, L, Montalto, A, Musumeci, F, Circelli, A, Gamberini, E, Russo, E, Benni, M, Agnoletti, V, Rociola, R, Milano, A, Grasso, S, Civita, A, Murgolo, F, Pilato, E, Comentale, G, Montisci, A, Alessandri, F, Tosi, A, Pugliese, F, Carelli, S, Grieco, D, Antonelli, M, Ramoni, E, Di Nardo, M, Maisano, F, Bettex, D, Weber, A, Grunenfelder, J, Consiglio, J, Hansjoerg, J, Haenggi, M, Agus, G, Doeble, T, Zenklusen, U, Bechtold, X, Stockman, B, De Backer, D, Giglioli, S, Meyns, B, Vercaemst, L, Herman, G, Meersseman, P, Vandenbriele, C, Dauwe, D, Vlasselaers, D, Raes, M, Debeuckelaere, G, Rodrigus, I, Biston, P, Piagnerelli, M, Peperstraete, H, Germay, O, Vandewiele, K, Vandeweghe, D, Witters, I, Havrin, S, Bourgeois, M, Taccone, F, Nobile, L, Lheureux, O, Brasseur, A, Creteur, J, Defraigne, J, Misset, B, Courcelle, R, Timmermans, P, Lehaen, J, Frederik, B, Riera, J, Castro, M, Gallart, E, Martinez-Martinez, M, Argudo, E, Garcia-de-Acilu, M, de Pablo Sanchez, R, Ortiz, A, Cabanes, M, Higa, K, Cassina, A, Berbel, D, Sanchez-Salado, J, Arnau, B, de Gopegui, P, Ricart, P, Sandoval, E, Veganzones, J, Millan, P, de la Sota, P, Santa Teresa, P, Alcantara, S, Alvarez, J, Gonzalez, A, Lopez, M, Gordillo, A, Naranjo-Izurieta, J, Costa, R, Albacete Moreno, C, de Ayala, J, Blanco-Schweizer, P, Andres, N, Boado, V, Martinez, J, Casal, V, Garcia, E, Martin-Villen, L, Climent, J, Pinto, L, Leprince, P, Lebreton, G, Juvin, C, Schmidt, M, Pineton, M, Folliguet, T, Saiydoun, G, Gaudard, P, Colson, P, Obadia, J, Pozzi, M, Fellahi, J, Yonis, H, Richard, J, Parasido, A, Verhoye, J, Flecher, E, Ajrhourh, L, Nesseler, N, Mansour, A, Guinot, P, Zarka, J, Besserve, P, Makhoul, M, Bolotin, G, Kassif, Y, Soufleris, D, Schellongowski, P, Bonaros, N, Krapf, C, Ebert, K, Mair, P, Kothleutner, F, Kowalewsky, M, Christensen, S, Pedersen, F, Balik, M, Blaha, J, Lips, M, Otahal, M, Camporota, L, Daly, K, Agnew, N, Barker, J, Head, L, Garcia, M, Ledot, S, Aquino, V, Lewis, R, Worthy, J, Noor, H, Scott, I, O'Brien, S, Conrick-Martin, I, Carton, E, Gillon, S, Flemming, L, Broman, L, Grins, E, Ketskalo, M, Tsarenko, S, Popugaev, K, Minin, S, Kornilov, I, Skopets, A, Kornelyuk, R, Turchaninov, A, Gorjup, V, Shelukhin, D, Dsouki, Y, Sargin, M, Kaygin, M, Liana, S, Puss, S, Soerensen, G, Magnus, R, Kanetoft, M, Watson, P, Redfors, B, Krenner, N, Velia Antonini, M, Barrett, N, Belliato, M, Davidson, M, Finney, S, Fowles, J, Halbe, M, Hennig, F, Jones, T, Smith, J, Roeleveld, P, Swol, J, Lorusso R., Combes A., Coco V. L., De Piero M. E., Belohlavek J., Delnoij T., van der Horst I., Miranda D. R., van der Linden M., van der Heijden J. J., Scholten E., van Belle-van Haren N., Lagrand W., de Jong S., Candura D., Maas J., van den Berg M. J. G., Malfertheiner M., Dreier E., Mueller T., Boeken U., Akhyari P., Lichtenberg A., Saeed D., Thiele H., Baumgaertel M., Schmitto J. D., Mariani S., Thielmann M., Brenner T., Benk C., Czerny M., Kalbhenn J., Maier S., Schibilsky D., Staudacher D. L., Henn P., Iuliu T., Muellenbach R., Reyher C., Rolfes C., Zacharowski K., Lotz G., Sonntagbauer M., Kersten A., Karagiannidis C., Schafer S., Fichte J., Hopf H. -B., Samalavicius R., Lorini L., Ghitti D., Grazioli L., Loforte A., Baiocchi M., Checco E. D., Pacini D., Meani P., Cappai A., Russo C. F., Bottiroli M., Mondino M., Ranucci M., Fina D., Ballotta A., Scandroglio A. M., Zangrillo A., Pieri M., Nardelli P., Fominskiy E., Landoni G., Fanelli V., Brazzi L., Montrucchio G., Sales G., Simonetti U., Urbino R., Livigni S., Degani A., Raffa G., Pilato M., Martucci G., Arcadipane A., Chiarini G., Latronico N., Cattaneo S., Puglia C., Reina G., Sponga S., Livi U., Foti G., Giani M., Rona R., Avalli L., Bombino M., Costa M. C., Carozza R., Donati A., Piciche M., Favaro A., Salvador L., Danzi V., Zanin A., Condello I., Fiore F., Moscarelli M., Nasso G., Speziale G., Sandrelli L., Montalto A., Musumeci F., Circelli A., Gamberini E., Russo E., Benni M., Agnoletti V., Rociola R., Milano A. D., Grasso S., Civita A., Murgolo F., Pilato E., Comentale G., Montisci A., Alessandri F., Tosi A., Pugliese F., Carelli S., Grieco D. L., Antonelli M., Ramoni E., Di Nardo M., Maisano F., Bettex D., Weber A., Grunenfelder J., Consiglio J., Hansjoerg J., Haenggi M., Agus G., Doeble T., Zenklusen U., Bechtold X., Stockman B., De Backer D., Giglioli S., Meyns B., Vercaemst L., Herman G., Meersseman P., Vandenbriele C., Dauwe D., Vlasselaers D., Raes M., Debeuckelaere G., Rodrigus I., Biston P., Piagnerelli M., Peperstraete H., Germay O., Vandewiele K., Vandeweghe D., Witters I., Havrin S., Bourgeois M., Taccone F. S., Nobile L., Lheureux O., Brasseur A., Creteur J., Defraigne J. -O., Misset B., Courcelle R., Timmermans P. J., Lehaen J., Frederik B., Riera J., Castro M. A., Gallart E., Martinez-Martinez M., Argudo E., Garcia-de-Acilu M., de Pablo Sanchez R., Ortiz A. B., Cabanes M. -P. F., Higa K. O., Cassina A. M., Berbel D. O., Sanchez-Salado J. C., Arnau B. -L., de Gopegui P. R., Ricart P., Sandoval E., Veganzones J., Millan P., de la Sota P., Santa Teresa P., Alcantara S., Alvarez J. D., Gonzalez A. V., Lopez M., Gordillo A., Naranjo-Izurieta J., Costa R. G., Albacete Moreno C. L., de Ayala J. A., Blanco-Schweizer P., Andres N. H., Boado V., Martinez J. M. N., Casal V. G., Garcia E. F., Martin-Villen L., Climent J. C., Pinto L. F., Leprince P., Lebreton G., Juvin C., Schmidt M., Pineton M., Folliguet T., Saiydoun G., Gaudard P., Colson P., Obadia J. -F., Pozzi M., Fellahi J. L., Yonis H., Richard J. C., Parasido A., Verhoye J. -P., Flecher E., Ajrhourh L., Nesseler N., Mansour A., Guinot P. -G., Zarka J., Besserve P., Makhoul M., Bolotin G., Kassif Y., Soufleris D., Schellongowski P., Bonaros N., Krapf C., Ebert K., Mair P., Kothleutner F., Kowalewsky M., Christensen S., Pedersen F. M., Balik M., Blaha J., Lips M., Otahal M., Camporota L., Daly K., Agnew N., Barker J., Head L., Garcia M., Ledot S., Aquino V., Lewis R., Worthy J., Noor H., Scott I., O'Brien S., Conrick-Martin I., Carton E., Gillon S., Flemming L., Broman L. M., Grins E., Ketskalo M., Tsarenko S., Popugaev K., Minin S., Kornilov I., Skopets A., Kornelyuk R., Turchaninov A., Gorjup V., Shelukhin D., Dsouki Y. E., Sargin M., Kaygin M. A., Liana S., Puss S., Soerensen G., Magnus R., Kanetoft M., Watson P., Redfors B., Krenner N., Velia Antonini M., Barrett N. A., Belliato M., Davidson M., Finney S., Fowles J. -A., Halbe M., Hennig F., Jones T., Pinto L., Smith J., Roeleveld P., Swol J., Lorusso, R, Combes, A, Coco, V, De Piero, M, Belohlavek, J, Delnoij, T, van der Horst, I, Miranda, D, van der Linden, M, van der Heijden, J, Scholten, E, van Belle-van Haren, N, Lagrand, W, de Jong, S, Candura, D, Maas, J, van den Berg, M, Malfertheiner, M, Dreier, E, Mueller, T, Boeken, U, Akhyari, P, Lichtenberg, A, Saeed, D, Thiele, H, Baumgaertel, M, Schmitto, J, Mariani, S, Thielmann, M, Brenner, T, Benk, C, Czerny, M, Kalbhenn, J, Maier, S, Schibilsky, D, Staudacher, D, Henn, P, Iuliu, T, Muellenbach, R, Reyher, C, Rolfes, C, Zacharowski, K, Lotz, G, Sonntagbauer, M, Kersten, A, Karagiannidis, C, Schafer, S, Fichte, J, Hopf, H, Samalavicius, R, Lorini, L, Ghitti, D, Grazioli, L, Loforte, A, Baiocchi, M, Checco, E, Pacini, D, Meani, P, Cappai, A, Russo, C, Bottiroli, M, Mondino, M, Ranucci, M, Fina, D, Ballotta, A, Scandroglio, A, Zangrillo, A, Pieri, M, Nardelli, P, Fominskiy, E, Landoni, G, Fanelli, V, Brazzi, L, Montrucchio, G, Sales, G, Simonetti, U, Urbino, R, Livigni, S, Degani, A, Raffa, G, Pilato, M, Martucci, G, Arcadipane, A, Chiarini, G, Latronico, N, Cattaneo, S, Puglia, C, Reina, G, Sponga, S, Livi, U, Foti, G, Giani, M, Rona, R, Avalli, L, Bombino, M, Costa, M, Carozza, R, Donati, A, Piciche, M, Favaro, A, Salvador, L, Danzi, V, Zanin, A, Condello, I, Fiore, F, Moscarelli, M, Nasso, G, Speziale, G, Sandrelli, L, Montalto, A, Musumeci, F, Circelli, A, Gamberini, E, Russo, E, Benni, M, Agnoletti, V, Rociola, R, Milano, A, Grasso, S, Civita, A, Murgolo, F, Pilato, E, Comentale, G, Montisci, A, Alessandri, F, Tosi, A, Pugliese, F, Carelli, S, Grieco, D, Antonelli, M, Ramoni, E, Di Nardo, M, Maisano, F, Bettex, D, Weber, A, Grunenfelder, J, Consiglio, J, Hansjoerg, J, Haenggi, M, Agus, G, Doeble, T, Zenklusen, U, Bechtold, X, Stockman, B, De Backer, D, Giglioli, S, Meyns, B, Vercaemst, L, Herman, G, Meersseman, P, Vandenbriele, C, Dauwe, D, Vlasselaers, D, Raes, M, Debeuckelaere, G, Rodrigus, I, Biston, P, Piagnerelli, M, Peperstraete, H, Germay, O, Vandewiele, K, Vandeweghe, D, Witters, I, Havrin, S, Bourgeois, M, Taccone, F, Nobile, L, Lheureux, O, Brasseur, A, Creteur, J, Defraigne, J, Misset, B, Courcelle, R, Timmermans, P, Lehaen, J, Frederik, B, Riera, J, Castro, M, Gallart, E, Martinez-Martinez, M, Argudo, E, Garcia-de-Acilu, M, de Pablo Sanchez, R, Ortiz, A, Cabanes, M, Higa, K, Cassina, A, Berbel, D, Sanchez-Salado, J, Arnau, B, de Gopegui, P, Ricart, P, Sandoval, E, Veganzones, J, Millan, P, de la Sota, P, Santa Teresa, P, Alcantara, S, Alvarez, J, Gonzalez, A, Lopez, M, Gordillo, A, Naranjo-Izurieta, J, Costa, R, Albacete Moreno, C, de Ayala, J, Blanco-Schweizer, P, Andres, N, Boado, V, Martinez, J, Casal, V, Garcia, E, Martin-Villen, L, Climent, J, Pinto, L, Leprince, P, Lebreton, G, Juvin, C, Schmidt, M, Pineton, M, Folliguet, T, Saiydoun, G, Gaudard, P, Colson, P, Obadia, J, Pozzi, M, Fellahi, J, Yonis, H, Richard, J, Parasido, A, Verhoye, J, Flecher, E, Ajrhourh, L, Nesseler, N, Mansour, A, Guinot, P, Zarka, J, Besserve, P, Makhoul, M, Bolotin, G, Kassif, Y, Soufleris, D, Schellongowski, P, Bonaros, N, Krapf, C, Ebert, K, Mair, P, Kothleutner, F, Kowalewsky, M, Christensen, S, Pedersen, F, Balik, M, Blaha, J, Lips, M, Otahal, M, Camporota, L, Daly, K, Agnew, N, Barker, J, Head, L, Garcia, M, Ledot, S, Aquino, V, Lewis, R, Worthy, J, Noor, H, Scott, I, O'Brien, S, Conrick-Martin, I, Carton, E, Gillon, S, Flemming, L, Broman, L, Grins, E, Ketskalo, M, Tsarenko, S, Popugaev, K, Minin, S, Kornilov, I, Skopets, A, Kornelyuk, R, Turchaninov, A, Gorjup, V, Shelukhin, D, Dsouki, Y, Sargin, M, Kaygin, M, Liana, S, Puss, S, Soerensen, G, Magnus, R, Kanetoft, M, Watson, P, Redfors, B, Krenner, N, Velia Antonini, M, Barrett, N, Belliato, M, Davidson, M, Finney, S, Fowles, J, Halbe, M, Hennig, F, Jones, T, Smith, J, Roeleveld, P, Swol, J, Lorusso R., Combes A., Coco V. L., De Piero M. E., Belohlavek J., Delnoij T., van der Horst I., Miranda D. R., van der Linden M., van der Heijden J. J., Scholten E., van Belle-van Haren N., Lagrand W., de Jong S., Candura D., Maas J., van den Berg M. J. G., Malfertheiner M., Dreier E., Mueller T., Boeken U., Akhyari P., Lichtenberg A., Saeed D., Thiele H., Baumgaertel M., Schmitto J. D., Mariani S., Thielmann M., Brenner T., Benk C., Czerny M., Kalbhenn J., Maier S., Schibilsky D., Staudacher D. L., Henn P., Iuliu T., Muellenbach R., Reyher C., Rolfes C., Zacharowski K., Lotz G., Sonntagbauer M., Kersten A., Karagiannidis C., Schafer S., Fichte J., Hopf H. -B., Samalavicius R., Lorini L., Ghitti D., Grazioli L., Loforte A., Baiocchi M., Checco E. D., Pacini D., Meani P., Cappai A., Russo C. F., Bottiroli M., Mondino M., Ranucci M., Fina D., Ballotta A., Scandroglio A. M., Zangrillo A., Pieri M., Nardelli P., Fominskiy E., Landoni G., Fanelli V., Brazzi L., Montrucchio G., Sales G., Simonetti U., Urbino R., Livigni S., Degani A., Raffa G., Pilato M., Martucci G., Arcadipane A., Chiarini G., Latronico N., Cattaneo S., Puglia C., Reina G., Sponga S., Livi U., Foti G., Giani M., Rona R., Avalli L., Bombino M., Costa M. C., Carozza R., Donati A., Piciche M., Favaro A., Salvador L., Danzi V., Zanin A., Condello I., Fiore F., Moscarelli M., Nasso G., Speziale G., Sandrelli L., Montalto A., Musumeci F., Circelli A., Gamberini E., Russo E., Benni M., Agnoletti V., Rociola R., Milano A. D., Grasso S., Civita A., Murgolo F., Pilato E., Comentale G., Montisci A., Alessandri F., Tosi A., Pugliese F., Carelli S., Grieco D. L., Antonelli M., Ramoni E., Di Nardo M., Maisano F., Bettex D., Weber A., Grunenfelder J., Consiglio J., Hansjoerg J., Haenggi M., Agus G., Doeble T., Zenklusen U., Bechtold X., Stockman B., De Backer D., Giglioli S., Meyns B., Vercaemst L., Herman G., Meersseman P., Vandenbriele C., Dauwe D., Vlasselaers D., Raes M., Debeuckelaere G., Rodrigus I., Biston P., Piagnerelli M., Peperstraete H., Germay O., Vandewiele K., Vandeweghe D., Witters I., Havrin S., Bourgeois M., Taccone F. S., Nobile L., Lheureux O., Brasseur A., Creteur J., Defraigne J. -O., Misset B., Courcelle R., Timmermans P. J., Lehaen J., Frederik B., Riera J., Castro M. A., Gallart E., Martinez-Martinez M., Argudo E., Garcia-de-Acilu M., de Pablo Sanchez R., Ortiz A. B., Cabanes M. -P. F., Higa K. O., Cassina A. M., Berbel D. O., Sanchez-Salado J. C., Arnau B. -L., de Gopegui P. R., Ricart P., Sandoval E., Veganzones J., Millan P., de la Sota P., Santa Teresa P., Alcantara S., Alvarez J. D., Gonzalez A. V., Lopez M., Gordillo A., Naranjo-Izurieta J., Costa R. G., Albacete Moreno C. L., de Ayala J. A., Blanco-Schweizer P., Andres N. H., Boado V., Martinez J. M. N., Casal V. G., Garcia E. F., Martin-Villen L., Climent J. C., Pinto L. F., Leprince P., Lebreton G., Juvin C., Schmidt M., Pineton M., Folliguet T., Saiydoun G., Gaudard P., Colson P., Obadia J. -F., Pozzi M., Fellahi J. L., Yonis H., Richard J. C., Parasido A., Verhoye J. -P., Flecher E., Ajrhourh L., Nesseler N., Mansour A., Guinot P. -G., Zarka J., Besserve P., Makhoul M., Bolotin G., Kassif Y., Soufleris D., Schellongowski P., Bonaros N., Krapf C., Ebert K., Mair P., Kothleutner F., Kowalewsky M., Christensen S., Pedersen F. M., Balik M., Blaha J., Lips M., Otahal M., Camporota L., Daly K., Agnew N., Barker J., Head L., Garcia M., Ledot S., Aquino V., Lewis R., Worthy J., Noor H., Scott I., O'Brien S., Conrick-Martin I., Carton E., Gillon S., Flemming L., Broman L. M., Grins E., Ketskalo M., Tsarenko S., Popugaev K., Minin S., Kornilov I., Skopets A., Kornelyuk R., Turchaninov A., Gorjup V., Shelukhin D., Dsouki Y. E., Sargin M., Kaygin M. A., Liana S., Puss S., Soerensen G., Magnus R., Kanetoft M., Watson P., Redfors B., Krenner N., Velia Antonini M., Barrett N. A., Belliato M., Davidson M., Finney S., Fowles J. -A., Halbe M., Hennig F., Jones T., Pinto L., Smith J., Roeleveld P., and Swol J.

Published
2021

16. COVID-19 in Heart Transplant Recipients: A Multicenter Analysis of the Northern Italian Outbreak

Author

Bottio, T, Bagozzi, L, Fiocco, A, Nadali, M, Caraffa, R, Bifulco, O, Ponzoni, M, Lombardi, C, Metra, M, Russo, C, Frigerio, M, Masciocco, G, Potena, L, Loforte, A, Pacini, D, Faggian, G, Onorati, F, Sponga, S, Livi, U, Iacovoni, A, Terzi, A, Senni, M, Rinaldi, M, Boffini, M, Marro, M, Jorgji, V, Carrozzini, M, Gerosa, G, Bottio T, Bagozzi L, Fiocco A, Nadali M, Caraffa R, Bifulco O, Ponzoni M, Lombardi CM, Metra M, Russo CF, Frigerio M, Masciocco G, Potena L, Loforte A, Pacini D, Faggian G, Onorati F, Sponga S, Livi U, Iacovoni A, Terzi A, Senni M, Rinaldi M, Boffini M, Marro M, Jorgji V, Carrozzini M, Gerosa G, Bottio, T, Bagozzi, L, Fiocco, A, Nadali, M, Caraffa, R, Bifulco, O, Ponzoni, M, Lombardi, C, Metra, M, Russo, C, Frigerio, M, Masciocco, G, Potena, L, Loforte, A, Pacini, D, Faggian, G, Onorati, F, Sponga, S, Livi, U, Iacovoni, A, Terzi, A, Senni, M, Rinaldi, M, Boffini, M, Marro, M, Jorgji, V, Carrozzini, M, Gerosa, G, Bottio T, Bagozzi L, Fiocco A, Nadali M, Caraffa R, Bifulco O, Ponzoni M, Lombardi CM, Metra M, Russo CF, Frigerio M, Masciocco G, Potena L, Loforte A, Pacini D, Faggian G, Onorati F, Sponga S, Livi U, Iacovoni A, Terzi A, Senni M, Rinaldi M, Boffini M, Marro M, Jorgji V, Carrozzini M, and Gerosa G

Abstract

Objectives: The aim of this study was to assess the clinical course and outcomes of all heart transplant recipients affected by coronavirus disease-2019 (COVID-19) who were followed at the leading heart transplant centers of Northern Italy. Background: The worldwide severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has created unprecedented challenges for public health, demanding exceptional efforts for the successful management and treatment of affected patients. Heart transplant patients represent a unique cohort of chronically immunosuppressed subjects in which SARS-CoV-2 may stimulate an unpredictable clinical course of infection. Methods: Since February 2020, we enrolled all 47 cases (79% male) in a first cohort of patients, with a mean age of 61.8 ± 14.5 years, who tested positive for SARS-CoV-2, out of 2,676 heart transplant recipients alive before the onset of the COVID-19 pandemic at 7 heart transplant centers in Northern Italy. Results: To date, 38 patients required hospitalization while 9 remained self-home quarantined and 14 died. Compared to the general population, prevalence (18 vs. 7 cases per 1,000) and related case fatality rate (29.7% vs. 15.4%) in heart transplant recipients were doubled. Univariable analysis showed older age (p = 0.002), diabetes mellitus (p = 0.040), extracardiac arteriopathy (p = 0.040), previous PCI (p = 0.040), CAV score (p = 0.039), lower GFR (p = 0.004), and higher NYHA functional classes (p = 0.023) were all significantly associated with in-hospital mortality. During the follow-up two patients died and a third patient has prolonged viral-shedding alternating positive and negative swabs. Since July 1st, 2020, we had 6 new patients who tested positive for SARS-CoV-2, 5 patients asymptomatic were self-quarantined, while 1 is still hospitalized for pneumonia. A standard therapy was maintained for all, except for the hospitalized patient. Conclusions: The prevalence and mortality of SARS-CoV-2 should spur cl

Published
2021

17. COVID-19 in Heart Transplant Recipients: A Multicenter Analysis of the Northern Italian Outbreak

Author

Bottio T, Bagozzi L, Fiocco A, Nadali M, Caraffa R, Bifulco O, Ponzoni M, Lombardi CM, Metra M, Russo CF, Frigerio M, Masciocco G, Potena L, Loforte A, Pacini D, Faggian G, Onorati F, Sponga S, Livi U, Iacovoni A, Terzi A, Senni M, Rinaldi M, Boffini M, Marro M, Jorgji V, Carrozzini M, Gerosa G, Bottio T., Bagozzi L., Fiocco A., Nadali M., Caraffa R., Bifulco O., Ponzoni M., Lombardi C.M., Metra M., Russo C.F., Frigerio M., Masciocco G., Potena L., Loforte A., Pacini D., Faggian G., Onorati F., Sponga S., Livi U., Iacovoni A., Terzi A., Senni M., Rinaldi M., Boffini M., Marro M., Jorgji V., Carrozzini M., Gerosa G., Bottio, T, Bagozzi, L, Fiocco, A, Nadali, M, Caraffa, R, Bifulco, O, Ponzoni, M, Lombardi, C, Metra, M, Russo, C, Frigerio, M, Masciocco, G, Potena, L, Loforte, A, Pacini, D, Faggian, G, Onorati, F, Sponga, S, Livi, U, Iacovoni, A, Terzi, A, Senni, M, Rinaldi, M, Boffini, M, Marro, M, Jorgji, V, Carrozzini, M, and Gerosa, G

Subjects
Male, COVID-19 and heart transplant recipient, TAPSE, Tricuspid annular plane systolic excursion, immunosuppressive therapy, COPD, Chronic obstructive pulmonary disease, BMI, Body mass index, Comorbidity, heart transplantation, Article, COVID-19 and heart transplant recipients, Follow-Up Studie, ECLS, Extracorporeal life support, SARS-CoV-2, Severe Acute Respiratory Syndrome-Coronavirus-2, Retrospective Studie, ICU, Intensive Care Unit, ARDS, Acute respiratory distress syndrome, Humans, COVID-19, Coronavirus Disease 19, sPAP, Systolic pulmonary artery pressure, PCI, Percutaneous coronary intervention, Hospital Mortality, NYHA, New York Heart Association, Pandemics, Aged, Retrospective Studies, RT-PCR, Reverse transcriptase-polymerase chain reaction, Heart Failure, Pandemic, SARS-CoV-2, ALT, Alanine aminotransferase, COVID-19, Female, Follow-Up Studies, Italy, Middle Aged, Heart Transplantation, Transplant Recipients, CAV, Cardiac allograft vasculopathy, GFR, Glomerular filtration rate, CRP, C-reactive Protein, WBC, White blood cells, LVEF, Left ventricular ejection fraction, PCT, Procalcitonin, iLVEDV, Indexed left ventricular end-diastolic volume, AST, Aspartate aminotransferase, Human
Abstract

Aims The aim of this study was to assess the clinical course and outcomes of all heart transplant recipients affected by COVID-19 who were followed at the leading heart transplant centers of Northern Italy. Method and Results Since February 2020, we enrolled all 47 cases (79% male) in a first cohort of patients, with a mean age of 61.8 ± 14.5 years, who tested positive for SARS-CoV-2, out of 2676 heart transplant recipients alive before the onset of the COVID-19 pandemic at 7 heart transplant centers in Northern Italy. To date, 38 patients required hospitalization while 9 remained self-home quarantined and 14 died. Compared to the general population, prevalence (18 vs 7 cases per 1000) and related case fatality rate (29.7 vs 15.4%) in heart transplant recipients were doubled. Univariable analysis showed older age (p=0.002), diabetes mellitus (p=0.040), extracardiac arteriopathy (p=0.040), previous PCI (p=0.040), CAV score (p=0.039), lower GFR (p=0.004), and higher NYHA classes (p=0.023) were all significantly associated with in-hospital mortality. During the follow-up two patients died and a third patient has prolonged viral-shedding alternating positive and negative swabs. Since 1st July 2020, we had 6 new patients who tested positive for SARS-CoV-2, 5 patients asymptomatic were self-quarantined, while 1 is still hospitalized for pneumonia. A standard therapy was maintained for all, except for the hospitalized patient. Conclusion The prevalence and mortality of SARS-CoV-2 should spur clinicians to immediately refer heart transplant recipients suspected as having SARS-CoV2 infection to centers specializing in the care of this vulnerable population., Graphical abstract

Published
2021

21. C15 DOES THE DISTANCE BETWEEN RESIDENCY AND IMPLANTING CENTER AFFECT THE OUTCOME OF PATIENTS SUPPORTED BY LEFT VENTRICULAR ASSIST DEVICE? A MULTICENTER ITALIAN STUDY ON RADIAL MECHANICALLY ASSISTED CIRCULATORY SUPPORT (MIRAMACS) ANALYSIS

Author

Lechiancole, A, primary, Loforte, A, additional, Trumello, C, additional, Scandroglio, M, additional, Gliozzi, G, additional, Comisso, M, additional, Iacovoni, A, additional, Terzi, A, additional, Maiani, M, additional, Musumeci, F, additional, De Bonis, M, additional, Pacini, D, additional, and Livi, U, additional

Published
2022
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25. Multicenter Italian Study on Radial Mechanically Assisted Circulatory Support (MIRAMACS): Ongoing Analyses

Author

Loforte, A., primary, Gliozzi, G., additional, Attisani, M., additional, Comisso, M., additional, Iacovoni, A., additional, Maiani, M., additional, Boschi, S., additional, Onorati, F., additional, Scandroglio, M., additional, Baronetto, A., additional, Terzi, A., additional, De Bonis, M., additional, Santini, F., additional, Faggian, G., additional, Livi, U., additional, Musumeci, F., additional, Rinaldi, M., additional, and Pacini, D., additional

Published
2022
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27. The Clinicopathologic Spectrum of Hypertrophic Cardiomyopathy. The Experience of the Italian Heart Transplant Program

Author

Baroldi, G., Rapezzi, C., De Maria, R., Angelini, E., Arbustini, E., Bonacina, E., Bosman, C., Catani, G., De Biase, L., Donegani, E., Fiocchi, A., Gagliardi, G., Gallo, P., Gavazzi, A., Gronda, E., Leone, O., Livi, U., Parma, A., Porcu, M., Pucci, A., Thiene, G., Viganò, M., Camerini, Fulvio, editor, Gavazzi, Antonello, editor, and De Maria, Renata, editor

Published
1998
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30. Surgical treatment of isolated tricuspid valve infective endocarditis: 25-year results from a multicenter registry

Author

Di Mauro, M, Foschi, M, Dato, G, Centofanti, P, Barili, F, Corte, A, Ratta, E, Cugola, D, Galletti, L, Santini, F, Salsano, A, Rinaldi, M, Mancuso, S, Cappabianca, G, Beghi, C, De Vincentiis, C, Biondi, A, Livi, U, Sponga, S, Pacini, D, Murana, G, Scrofani, R, Antona, C, Cagnoni, G, Nicolini, F, Benassi, F, De Bonis, M, Pozzoli, A, Casali, G, Scrascia, G, Falcetta, G, Bortolotti, U, Musumeci, F, Gherli, R, Vizzardi, E, Salvador, L, Piciche, M, Paparella, D, Margari, V, Troise, G, Villa, E, Dossena, Y, Lucarelli, C, Onorati, F, Faggian, G, Mariscalco, G, Maselli, D, Parolari, A, Lorusso, R, Di Mauro M., Foschi M., Dato G. M. A., Centofanti P., Barili F., Corte A. D., Ratta E. D., Cugola D., Galletti L., Santini F., Salsano A., Rinaldi M., Mancuso S., Cappabianca G., Beghi C., De Vincentiis C., Biondi A., Livi U., Sponga S., Pacini D., Murana G., Scrofani R., Antona C., Cagnoni G., Nicolini F., Benassi F., De Bonis M., Pozzoli A., Casali G., Scrascia G., Falcetta G., Bortolotti U., Musumeci F., Gherli R., Vizzardi E., Salvador L., Piciche M., Paparella D., Margari V., Troise G., Villa E., Dossena Y., Lucarelli C., Onorati F., Faggian G., Mariscalco G., Maselli D., Parolari A., Lorusso R., Di Mauro, M, Foschi, M, Dato, G, Centofanti, P, Barili, F, Corte, A, Ratta, E, Cugola, D, Galletti, L, Santini, F, Salsano, A, Rinaldi, M, Mancuso, S, Cappabianca, G, Beghi, C, De Vincentiis, C, Biondi, A, Livi, U, Sponga, S, Pacini, D, Murana, G, Scrofani, R, Antona, C, Cagnoni, G, Nicolini, F, Benassi, F, De Bonis, M, Pozzoli, A, Casali, G, Scrascia, G, Falcetta, G, Bortolotti, U, Musumeci, F, Gherli, R, Vizzardi, E, Salvador, L, Piciche, M, Paparella, D, Margari, V, Troise, G, Villa, E, Dossena, Y, Lucarelli, C, Onorati, F, Faggian, G, Mariscalco, G, Maselli, D, Parolari, A, Lorusso, R, Di Mauro M., Foschi M., Dato G. M. A., Centofanti P., Barili F., Corte A. D., Ratta E. D., Cugola D., Galletti L., Santini F., Salsano A., Rinaldi M., Mancuso S., Cappabianca G., Beghi C., De Vincentiis C., Biondi A., Livi U., Sponga S., Pacini D., Murana G., Scrofani R., Antona C., Cagnoni G., Nicolini F., Benassi F., De Bonis M., Pozzoli A., Casali G., Scrascia G., Falcetta G., Bortolotti U., Musumeci F., Gherli R., Vizzardi E., Salvador L., Piciche M., Paparella D., Margari V., Troise G., Villa E., Dossena Y., Lucarelli C., Onorati F., Faggian G., Mariscalco G., Maselli D., Parolari A., and Lorusso R.

Abstract

Background: To assess early and late mortality in patients with isolated acute tricuspid valve infective endocarditis (TVIE) using data from a multicenter registry. Methods: From 1983 to 2018, isolated acute TVIE was surgically treated in 157 (3.8%) patients [mean age 47 ± 16 years (range 15–86 years), 25% females]. Of these, 142 (90%) had native tricuspid regurgitation, 7 (5%) native tricuspid valve (TV) steno-regurgitation, and 8 (5%) prosthetic TVIE. Intravenous drug use (IVDU) was recorded in 38% of patients, infection involved cardiac implantable electronic device leads in 21%, and vascular catheters for dialysis in 1%; in the remaining cases, the cause was unknown. The primary endpoint was in-hospital outcome, long-term freedom from recurrence and overall survival. Results: Overall, 77 (49%) patients underwent TV repair, 72 (46%) TV replacement, and 8 (5%) prosthetic TV replacement. Early mortality was 11% (n = 17). Expected early mortality according to EndoSCORE was 12%, with age (odds ratio 1.06) and redo (odds ratio 6.64) as risk factors. Late deaths occurred in 31 patients and TVIE recurrences in 4. Survival rates at 10, 20, and 25 years were 66%, 60%, and 44%, respectively. Risk factors were age [hazard ratio (HR) 1.06], mycotic TVIE (HR 4.2), IVDU (HR 4.90), infected prosthesis replacement (HR 4.4), and presence of cardiac implantable electronic device leads (HR 3.0). No significant difference was found in valve repair vs. replacement and in IVDUs vs. non-IVDUs. Conclusions: Patients with isolated acute TVIE undergoing surgical treatment show acceptable early and late outcomes. TVIE recurrence was low, and repair of the affected valve does not seem to confer any advantage either at early or long term up to 25 years.

Published
2019

31. Factors Influencing Access to Transplant, Waitlist Mortality, and Post-Transplant Survival in the Italian National Heart Transplant Database

Author

Frigerio, M, Varrenti, M, Santolamazza, C, Bernasconi, D, Costa, A, Oliveti, A, Puoti, F, Bottio, T, Gerosa, G, Russo, C, Giannattasio, C, Tursi, V, Livi, U, Maiello, C, Amarelli, C, Potena, L, Martin Suarez, S, Boffini, M, Pace Napoleone, C, Clemenza, F, Musumeci, F, Maccherini, M, Faggian, G, Pellegrini, C, Terzi, A, Tramontin, C, De Angelis, D, Milano, A, Valsecchi, M, Frigerio, M., Varrenti, M., Santolamazza, C., Bernasconi, D. P., Costa, A. Nanni, Oliveti, A., Puoti, F., Bottio, T., Gerosa, G., Russo, C. F., Giannattasio, C., Tursi, V., Livi, U., Maiello, C., Amarelli, C., Potena, L., Martin Suarez, S., Boffini, M., Pace Napoleone, C., Clemenza, F., Musumeci, F., Maccherini, M., Faggian, G., Pellegrini, C., Terzi, A., Tramontin, C., De Angelis, D., Milano, A. D., Valsecchi, M., Frigerio, M, Varrenti, M, Santolamazza, C, Bernasconi, D, Costa, A, Oliveti, A, Puoti, F, Bottio, T, Gerosa, G, Russo, C, Giannattasio, C, Tursi, V, Livi, U, Maiello, C, Amarelli, C, Potena, L, Martin Suarez, S, Boffini, M, Pace Napoleone, C, Clemenza, F, Musumeci, F, Maccherini, M, Faggian, G, Pellegrini, C, Terzi, A, Tramontin, C, De Angelis, D, Milano, A, Valsecchi, M, Frigerio, M., Varrenti, M., Santolamazza, C., Bernasconi, D. P., Costa, A. Nanni, Oliveti, A., Puoti, F., Bottio, T., Gerosa, G., Russo, C. F., Giannattasio, C., Tursi, V., Livi, U., Maiello, C., Amarelli, C., Potena, L., Martin Suarez, S., Boffini, M., Pace Napoleone, C., Clemenza, F., Musumeci, F., Maccherini, M., Faggian, G., Pellegrini, C., Terzi, A., Tramontin, C., De Angelis, D., Milano, A. D., and Valsecchi, M.

Published
2019

32. Validation of the patient assessment of chronic illness care (PACIC) short form scale in heart transplant recipients: the international cross-sectional bright study

Author

Iglesias, K, De Geest, S, Berben, L, Dobbels, F, Denhaerynk, K, Russell, Lc, Helmy, R, Peytremann-Bridevaux, I, Crespo-Leiro, Mg, DE SIMONE, Paolo, Groenewoud, A, Kugler, C, Ohler, L, Van Cleemput, J, Poncelet, Aj, Sebbag, L, Michel, M, Bernard, A, Doesch, A, Livi, U, Manfredini, V, Brossa-Loidi, V, Segovia-Cubero, J, Almenar-Bonet, L, Segura Saint-Gerons, C, Mohacsi, P, Horvath, E, Riotto, C, Parry, G, Firouzi, A, Kozuszko, S, Haddad, H, Kaan, A, Fisher, G, Miller, T, Flattery, M, Ludrosky, K, Coleman, B, Trammell, J, St Clair, K, Kao, A, Molina, M, Ryan Canales, K, Scalso de Almeida, S, Cotait Ayoub, A, Barone, F, Harkess, M, Maddicks-Law, J, BRIGHT study team, Crespo-Leiro, M.G., De Simone, P., Groenewoud, A., Kugler, C., Ohler, L., Van Cleemput, J., Poncelet, A.J., Sebbag, L., Michel, M., Bernard, A., Doesch, A., Livi, U., Manfredini, V., Brossa-Loidi, V., Segovia-Cubero, J., Almenar-Bonet, L., Segura Saint-Gerons, C., Mohacsi, P., Horvath, E., Riotto, C., Parry, G., Firouzi, A., Kozuszko, S., Haddad, H., Kaan, A., Fisher, G., Miller, T., Flattery, M., Ludrosky, K., Coleman, B., Trammell, J., St Clair, K., Kao, A., Molina, M., Ryan Canales, K., Scalso de Almeida, S., Cotait Ayoub, A., Barone, F., Harkess, M., and Maddicks-Law, J.

Subjects
Adult, Male, Canada, medicine.medical_specialty, Cross-sectional study, Transplant team, Multi-center trial, Chronic care model, Heart transplantation, Language, PACIC short form, Aged, Australia, Chronic Disease, Cross-Sectional Studies, Factor Analysis, Statistical, Female, Humans, Middle Aged, Reproducibility of Results, United Kingdom, United States, Heart Transplantation, Surveys and Questionnaires, Health informatics, Health administration, 03 medical and health sciences, 0302 clinical medicine, Chronic Disease/therapy, medicine, 030212 general & internal medicine, Chronic care, business.industry, lcsh:Public aspects of medicine, 030503 health policy & services, Health Policy, Nursing research, Public health, lcsh:RA1-1270, Statistical, Transplantation, Family medicine, Scale (social sciences), 0305 other medical science, business, Factor Analysis, Research Article
Abstract

Background Transplant recipients are chronically ill patients, who require lifelong follow-up to manage co-morbidities and prevent graft loss. This necessitates a system of care that is congruent with the Chronic Care Model. The eleven-item self-report Patient Assessment of Chronic Illness Care (PACIC) scale assesses whether chronic care is congruent with the Chronic Care Model, yet its validity for heart transplant patients has not been tested. Methods We tested the validity of the English version of the PACIC, and compared the similarity of the internal structure of the PACIC across English-speaking countries (USA, Canada, Australia and United Kingdom) and across six languages (French, German, Dutch, Spanish, Italian and Portuguese). This was done using data from the cross-sectional international BRIGHT study that included 1378 heart transplant patients from eleven countries across 4 continents. To test the validity of the instrument, confirmatory factor analyses to check the expected unidimensional internal structure, and relations to other variables, were performed. Results Main analyses confirmed the validity of the English PACIC version for heart transplant patients. Exploratory analyses across English-speaking countries and languages also confirmed the single factorial dimension, except in Italian and Spanish. Conclusion This scale could help healthcare providers monitor level of chronic illness management and improve transplantation care. Trial registration Clinicaltrials.gov ID: NCT01608477, first patient enrolled in March 2012, registered retrospectively: May 30, 2012.

Published
2020

35. Clinical outcomes after implantation of a sutureless aortic bioprosthesis with concomitant mitral valve surgery: the SURE-AVR registry

Author

Baghai, M., Glauber, M., Fontaine, R., Castillo, J.C., Walker, A.H., Livi, U., Montiel, José, Royse, A., Bisleri, G., Pacini, D., Argano, V., Roumy, A., Asimakopoulos, G., Solinas, M., and Padró Fernández, José María

Subjects
Aortic valve, Male, medicine.medical_treatment, Aortic valve stenosis, 030204 cardiovascular system & hematology, 0302 clinical medicine, Aortic valve replacement, Anesthesiology, 80 and over, RD78.3-87.3, Prospective Studies, Registries, Aged, 80 and over, Heart Valve Prosthesis Implantation, General Medicine, Cardiac surgery, medicine.anatomical_structure, Treatment Outcome, Cardiothoracic surgery, Valvular disease, Aged, Aortic Valve, Aortic Valve Stenosis, Female, Humans, Mitral Valve, Operative Time, Prosthesis Design, Reoperation, Bioprosthesis, Heart Valve Prosthesis, Aortic pressure, Cardiology and Cardiovascular Medicine, Research Article, Pulmonary and Respiratory Medicine, medicine.medical_specialty, RD1-811, 03 medical and health sciences, medicine, Mitral valve repair, business.industry, medicine.disease, Surgery, 030228 respiratory system, Implant, business
Abstract

Background Early treatment of aortic valve stenosis is recommended in eligible symptomatic patients with severe aortic valve stenosis who would otherwise have a poor prognosis. The sutureless aortic valve bioprosthesis offers an alternative to standard aortic valve replacement with a sutured valve, but limited data are available in patients who have undergone multiple valve procedures involving the new, sutureless technology. We sought to investigate outcomes in high operative risk patients with previous or concomitant valve surgery who were implanted with a sutureless valve. Methods SURE-AVR is an ongoing, prospective, multinational registry of patients undergoing aortic valve replacement. In-hospital and post-discharge outcomes up to 5 years were collected. Results The study population comprised 78 patients (mean ± SD: age 73.6 ± 7.6 years, logistic EuroSCORE 18.0 ± 17.5) enrolled at 13 sites who presented for concomitant or previous mitral valve repair (n = 45) or replacement (n = 33), with or without additional concomitant procedures, and were implanted with a sutureless valve. Mean ± SD overall aortic cross-clamp time was 109 ± 41 min and cardiopulmonary bypass time was 152 ± 49 min. Mean ± SD aortic pressure gradients decreased from 37.6 ± 17.7 mmHg preoperatively to 13.0 ± 5.7 mmHg at hospital discharge, and peak aortic pressure gradient from 61.5 ± 28.7 to 23.4 ± 10.6 mmHg. Early events included 1 death, 1 transient ischaemic attack, and 1 bleed (all 1.3%); a permanent pacemaker implantation was required in 6 patients (7.7%), and 2 reoperations (not valve related) (2.6%) took place. Over a median follow-up of 55.5 months (Q1 13.4, Q3 68.6), 12 patients died (6 cardiovascular and 6 non-cardiovascular, both 2.1% per patient-year). Five-year survival was 81.3%. Late paravalvular leak occurred in 2 patients (0.7% per patient-year) and permanent pacemaker implantation was required in 3 patients (0.1% per patient-year). There was no apparent rise in mean or peak aortic pressure gradient over the study. Conclusions These results suggest that the sutureless implant is a technically feasible procedure during mitral surgery and is associated with good clinical outcomes.

Published
2021

36. Correction to: European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria (Journal of Cardiothoracic Surgery, (2021), 16, 1, (171), 10.1186/s13019-021-01536-5)

Author

Biancari, F., Mariscalco, G., Yusuff, H., Tsang, G., Luthra, S., Onorati, F., Francica, A., Rossetti, C., Perrotti, A., Chocron, S., Fiore, A., Folliguet, T., Pettinari, M., Dell'Aquila, A. M., Demal, T., Conradi, L., Detter, C., Pol, M., Ivak, P., Schlosser, F., Forlani, S., Chetty, G., Harky, A., Kuduvalli, M., Field, M., Vendramin, I., Livi, U., Rinaldi, M., Ferrante, L., Etz, C., Noack, T., Mastrobuoni, S., De Kerchove, L., Jormalainen, M., Laga, S., Meuris, B., Schepens, M., Dean, Z. E., Vento, A., Raivio, P., Borger, M., and Juvonen, T.

Published
2021

37. Clinical outcomes after implantation of a sutureless aortic bioprosthesis with concomitant mitral valve surgery: the SURE-AVR registry

Author

Baghai, M, Glauber, M, Fontaine, R, Castillo, JC, Walker, AH, Livi, U, Montiel, J, Royse, A, Bisleri, G, Pacini, D, Argano, V, Roumy, A, Asimakopoulos, G, Solinas, M, Baghai, M, Glauber, M, Fontaine, R, Castillo, JC, Walker, AH, Livi, U, Montiel, J, Royse, A, Bisleri, G, Pacini, D, Argano, V, Roumy, A, Asimakopoulos, G, and Solinas, M

Abstract

BACKGROUND: Early treatment of aortic valve stenosis is recommended in eligible symptomatic patients with severe aortic valve stenosis who would otherwise have a poor prognosis. The sutureless aortic valve bioprosthesis offers an alternative to standard aortic valve replacement with a sutured valve, but limited data are available in patients who have undergone multiple valve procedures involving the new, sutureless technology. We sought to investigate outcomes in high operative risk patients with previous or concomitant valve surgery who were implanted with a sutureless valve. METHODS: SURE-AVR is an ongoing, prospective, multinational registry of patients undergoing aortic valve replacement. In-hospital and post-discharge outcomes up to 5 years were collected. RESULTS: The study population comprised 78 patients (mean ± SD: age 73.6 ± 7.6 years, logistic EuroSCORE 18.0 ± 17.5) enrolled at 13 sites who presented for concomitant or previous mitral valve repair (n = 45) or replacement (n = 33), with or without additional concomitant procedures, and were implanted with a sutureless valve. Mean ± SD overall aortic cross-clamp time was 109 ± 41 min and cardiopulmonary bypass time was 152 ± 49 min. Mean ± SD aortic pressure gradients decreased from 37.6 ± 17.7 mmHg preoperatively to 13.0 ± 5.7 mmHg at hospital discharge, and peak aortic pressure gradient from 61.5 ± 28.7 to 23.4 ± 10.6 mmHg. Early events included 1 death, 1 transient ischaemic attack, and 1 bleed (all 1.3%); a permanent pacemaker implantation was required in 6 patients (7.7%), and 2 reoperations (not valve related) (2.6%) took place. Over a median follow-up of 55.5 months (Q1 13.4, Q3 68.6), 12 patients died (6 cardiovascular and 6 non-cardiovascular, both 2.1% per patient-year). Five-year survival was 81.3%. Late paravalvular leak occurred in 2 patients (0.7% per patient-year) and permanent pacemaker implantation was required in 3 patients (0.1% per patient-year). There was no apparent rise in mean or pea

Published
2021

38. European registry of type A aortic dissection (ERTAAD):rationale, design and definition criteria

Author

Biancari, F. (Fausto), Mariscalco, G. (Giovanni), Yusuff, H. (Hakeem), Tsang, G. (Geoffrey), Luthra, S. (Suvitesh), Onorati, F. (Francesco), Francica, A. (Alessandra), Rossetti, C. (Cecilia), Perrotti, A. (Andrea), Chocron, S. (Sidney), Fiore, A. (Antonio), Folliguet, T. (Thierry), Pettinari, M. (Matteo), Dell’Aquila, A. M. (Angelo M.), Demal, T. (Till), Conradiv, L. (Lenard), Detter, C. (Christian), Pol, M. (Marek), Ivak, P. (Peter), Schlosser, F. (Filip), Forlani, S. (Stefano), Chetty, G. (Govind), Harky, A. (Amer), Kuduvalli, M. (Manoj), Field, M. (Mark), Vendramin, I. (Igor), Livi, U. (Ugolino), Rinaldi, M. (Mauro), Ferrante, L. (Luisa), Etz, C. (Christian), Noack, T. (Thilo), Mastrobuoni, S. (Stefano), De Kerchove, L. (Laurent), Jormalainen, M. (Mikko), Laga, S. (Steven), Meuris, B. (Bart), Schepens, M. (Marc), El Dean, Z. (Zein), Vento, A. (Antti), Raivio, P. (Peter), Borger, M. (Michael), Juvonen, T. (Tatu), Biancari, F. (Fausto), Mariscalco, G. (Giovanni), Yusuff, H. (Hakeem), Tsang, G. (Geoffrey), Luthra, S. (Suvitesh), Onorati, F. (Francesco), Francica, A. (Alessandra), Rossetti, C. (Cecilia), Perrotti, A. (Andrea), Chocron, S. (Sidney), Fiore, A. (Antonio), Folliguet, T. (Thierry), Pettinari, M. (Matteo), Dell’Aquila, A. M. (Angelo M.), Demal, T. (Till), Conradiv, L. (Lenard), Detter, C. (Christian), Pol, M. (Marek), Ivak, P. (Peter), Schlosser, F. (Filip), Forlani, S. (Stefano), Chetty, G. (Govind), Harky, A. (Amer), Kuduvalli, M. (Manoj), Field, M. (Mark), Vendramin, I. (Igor), Livi, U. (Ugolino), Rinaldi, M. (Mauro), Ferrante, L. (Luisa), Etz, C. (Christian), Noack, T. (Thilo), Mastrobuoni, S. (Stefano), De Kerchove, L. (Laurent), Jormalainen, M. (Mikko), Laga, S. (Steven), Meuris, B. (Bart), Schepens, M. (Marc), El Dean, Z. (Zein), Vento, A. (Antti), Raivio, P. (Peter), Borger, M. (Michael), and Juvonen, T. (Tatu)

Abstract

Background: Acute Stanford type A aortic dissection (TAAD) is a life-threatening condition. Surgery is usually performed as a salvage procedure and is associated with significant postoperative early mortality and morbidity. Understanding the patient’s conditions and treatment strategies which are associated with these adverse events is essential for an appropriate management of acute TAAD. Methods: Nineteen centers of cardiac surgery from seven European countries have collaborated to create a multicentre observational registry (ERTAAD), which will enroll consecutive patients who underwent surgery for acute TAAD from January 2005 to March 2021. Analysis of the impact of patient’s comorbidities, conditions at referral, surgical strategies and perioperative treatment on the early and late adverse events will be performed. The investigators have developed a classification of the urgency of the procedure based on the severity of preoperative hemodynamic conditions and malperfusion secondary to acute TAAD. The primary clinical outcomes will be in-hospital mortality, late mortality and reoperations on the aorta. Secondary outcomes will be stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit. Discussion: The analysis of this multicentre registry will allow conclusive results on the prognostic importance of critical preoperative conditions and the value of different treatment strategies to reduce the risk of early adverse events after surgery for acute TAAD. This registry is expected to provide insights into the long-term durability of different strategies of surgical repair for TAAD. Trial registration: ClinicalTrials.gov Identifier: NCT04831073.

Published
2021

39. Cardiac surgery practice during the COVID-19 outbreak: A multicentre national survey

Author

Rubino, A. S., De Santo, L. S., Pisano, Adelaide, Mauro, M. D., Benussi, S., Borghetti, V., Castiglioni, A., Chiariello, L., Colli, A., De Bellis, Andrea, De Filippo, C. M., De Paulis, R., Di Benedetto, G., Di Eusanio, M., Faggian, G., Fiorani, B., Fratto, P. A., Giuffrida, A. G., Glauber, M., Iannelli, G., Iesu, S., Livi, U., Martinelli, G., Massetti, Massimo, Mastroroberto, P., Menicanti, L., Minniti, G., Miraldi, F., Montesi, G., Musumeci, F., Nicolini, Francesco, Napoleone, C. P., Panisi, P., Pappalardo, A., Patane`, F., Ragni, T., Rinaldi, M., Tribastone, S., Triggiani, M., Tritto, F. P., Zebele, C., Parolari, A., Gerosa, G., De Feo, M., Antonino, S. R., Luca Salvatore, D. S., Antonio, P., Michele, D. M., Stefano, B., Valentino, B., Alessandro, C., Luigi, C., Andrea, C., Antonio, D. B., Carlo Maria, D. F., Ruggero, D. P., Giuseppe, D. B., Marco, D. E., Giuseppe, F., Brenno, F., Pasquale, A. F., Angelo Giuseppe, G., Mattia, Giuseppe, Gabriele, I., Severino, Iolanda, Ugolino, L., Gianluca, M., Massimo, M., Pasquale, M., Lorenzo, M., Giuseppe, M., Fabio, M., Gianfranco, M., Francesco, M., Francesco, N., Carlo Pace, N., Paolo, P., Aniello, P., Francesco, P., Temistocle, R., Mauro, R., Salvatore, T., Michele, T., Francesco Paolo, T., Carlo, Z., Alessandro, P., Gino, G., Marisa, D. F., Pisano A., De Bellis A., Massetti M. (ORCID:0000-0002-7100-8478), Nicolini F., Mattia G., Severino I., Rubino, A. S., De Santo, L. S., Pisano, Adelaide, Mauro, M. D., Benussi, S., Borghetti, V., Castiglioni, A., Chiariello, L., Colli, A., De Bellis, Andrea, De Filippo, C. M., De Paulis, R., Di Benedetto, G., Di Eusanio, M., Faggian, G., Fiorani, B., Fratto, P. A., Giuffrida, A. G., Glauber, M., Iannelli, G., Iesu, S., Livi, U., Martinelli, G., Massetti, Massimo, Mastroroberto, P., Menicanti, L., Minniti, G., Miraldi, F., Montesi, G., Musumeci, F., Nicolini, Francesco, Napoleone, C. P., Panisi, P., Pappalardo, A., Patane`, F., Ragni, T., Rinaldi, M., Tribastone, S., Triggiani, M., Tritto, F. P., Zebele, C., Parolari, A., Gerosa, G., De Feo, M., Antonino, S. R., Luca Salvatore, D. S., Antonio, P., Michele, D. M., Stefano, B., Valentino, B., Alessandro, C., Luigi, C., Andrea, C., Antonio, D. B., Carlo Maria, D. F., Ruggero, D. P., Giuseppe, D. B., Marco, D. E., Giuseppe, F., Brenno, F., Pasquale, A. F., Angelo Giuseppe, G., Mattia, Giuseppe, Gabriele, I., Severino, Iolanda, Ugolino, L., Gianluca, M., Massimo, M., Pasquale, M., Lorenzo, M., Giuseppe, M., Fabio, M., Gianfranco, M., Francesco, M., Francesco, N., Carlo Pace, N., Paolo, P., Aniello, P., Francesco, P., Temistocle, R., Mauro, R., Salvatore, T., Michele, T., Francesco Paolo, T., Carlo, Z., Alessandro, P., Gino, G., Marisa, D. F., Pisano A., De Bellis A., Massetti M. (ORCID:0000-0002-7100-8478), Nicolini F., Mattia G., and Severino I.

Abstract

OBJECTIVES: Healthcare systems worldwide have been overburdened by the coronavirus disease 2019 (COVID-19) outbreak. Accordingly, hospitals had to implement strategies to profoundly reshape both non-COVID-19 medical care and surgical activities. Knowledge about the impact of the COVID-19 pandemic on cardiac surgery practice is pivotal. The goal of the present study was to describe the changes in cardiac surgery practices during the health emergency at the national level. METHODS: A 26-question web-enabled survey including all adult cardiac surgery units in Italy was conducted to assess how their clinical practice changed during the national lockdown. Data were compared to data from the corresponding period in 2019. RESULTS: All but 2 centres (94.9%) adopted specific protocols to screen patients and personnel. A significant reduction in the number of dedicated cardiac intensive care unit beds (-35.4%) and operating rooms (-29.2%), along with healthcare personnel reallocation to COVID departments (nurses-15.4%, anaesthesiologists-7.7%), was noted. Overall adult cardiac surgery volumes were dramatically reduced (1734 procedures vs 3447; P 0.001), with a significant drop in elective procedures [580 (33.4%) vs 2420 (70.2%)]. CONCLUSIONS: This national survey found major changes in cardiac surgery practice as a response to the COVID-19 pandemic. This experience should lead to the development of permanent systems-based plans to face possible future pandemics. These data may effectively help policy decision-making in prioritizing healthcare resource reallocation during the ongoing pandemic and once the healthcare emergency is over. © 2021 The Author(s). Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Published
2021

41. Multicenter Italian Study on Radial Mechanically Assisted Circulatory Support (MIRAMACS): Preliminary Results

Author

Loforte, A., primary, Gliozzi, G., additional, Attisani, M., additional, Montalto, A., additional, Iacovoni, A., additional, Onorati, F., additional, Maiani, M., additional, Scandroglio, M., additional, Terzi, A., additional, De Bonis, M., additional, Faggian, G., additional, Livi, U., additional, Musumeci, F., additional, Rinaldi, M., additional, and Pacini, D., additional

Published
2021
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42. Extracorporeal Membrane Oxygenation for Early Graft Dysfunction Following Heart Transplantation: A Systematic Review and Meta-Analysis

Author

Aleksova, N., primary, Buchan, T.A., additional, Foroutan, F., additional, Zhu, A., additional, Noly, P., additional, Carrier, M., additional, Marasco, S.F., additional, Pozzi, M., additional, Lehmann, S., additional, Jawad, K., additional, Defontaine, A., additional, Baron, O., additional, Loforte, A., additional, Checco, E. Dal, additional, Absi, D.O., additional, Kawabori, M., additional, Mastroianni, M.A., additional, Simonenko, M., additional, Marichev, A., additional, Sponga, S., additional, Livi, U., additional, Orchanian-Cheff, A., additional, Ross, H.J., additional, Guyatt, G., additional, Billia, F., additional, and Alba, A.C., additional

Published
2021
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44. Corrigendum to “A predictive model for early mortality after surgical treatment of heart valve or prosthesis infective endocarditis. The EndoSCORE”. [Int. J. Cardiol. 241 (Aug 15 2017) 97–102](S0167527317309877)(10.1016/j.ijcard.2017.03.148)

Author

Di Mauro M., Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sponga, S, Pacini, D, Di Bartolomeo, R, Demartino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro M., Dato G. M. A., Barili F., Gelsomino S., Sante P., Corte A. D., Carrozza A., Ratta E. D., Cugola D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., Botta L., Russo C., Mancuso S., Rinaldi M., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., Tarzia V., Gerosa G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Rosato F., Grasso E., Livi U., Sponga S., Pacini D., Di Bartolomeo R., DeMartino A., Bortolotti U., Onorati F., Faggian G., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Piciche M., Musumeci F., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Foschi M., Parolari A., Nappi G., Di Mauro M., Di Mauro, M, Dato, G, Barili, F, Gelsomino, S, Sante, P, Corte, A, Carrozza, A, Ratta, E, Cugola, D, Galletti, L, Devotini, R, Casabona, R, Santini, F, Salsano, A, Scrofani, R, Antona, C, Botta, L, Russo, C, Mancuso, S, Rinaldi, M, De Vincentiis, C, Biondi, A, Beghi, C, Cappabianca, G, Tarzia, V, Gerosa, G, De Bonis, M, Pozzoli, A, Nicolini, F, Benassi, F, Rosato, F, Grasso, E, Livi, U, Sponga, S, Pacini, D, Di Bartolomeo, R, Demartino, A, Bortolotti, U, Onorati, F, Faggian, G, Lorusso, R, Vizzardi, E, Di Giammarco, G, Marinelli, D, Villa, E, Troise, G, Piciche, M, Musumeci, F, Paparella, D, Margari, V, Tritto, F, Damiani, G, Scrascia, G, Zaccaria, S, Renzulli, A, Serraino, G, Mariscalco, G, Maselli, D, Foschi, M, Parolari, A, Nappi, G, Di Mauro M., Dato G. M. A., Barili F., Gelsomino S., Sante P., Corte A. D., Carrozza A., Ratta E. D., Cugola D., Galletti L., Devotini R., Casabona R., Santini F., Salsano A., Scrofani R., Antona C., Botta L., Russo C., Mancuso S., Rinaldi M., De Vincentiis C., Biondi A., Beghi C., Cappabianca G., Tarzia V., Gerosa G., De Bonis M., Pozzoli A., Nicolini F., Benassi F., Rosato F., Grasso E., Livi U., Sponga S., Pacini D., Di Bartolomeo R., DeMartino A., Bortolotti U., Onorati F., Faggian G., Lorusso R., Vizzardi E., Di Giammarco G., Marinelli D., Villa E., Troise G., Piciche M., Musumeci F., Paparella D., Margari V., Tritto F., Damiani G., Scrascia G., Zaccaria S., Renzulli A., Serraino G., Mariscalco G., Maselli D., Foschi M., Parolari A., and Nappi G.

Abstract

The authors regret that the first name and last name of the author Sandro Sponga was published incorrectly in the original version and this has now been corrected.

Published
2018

45. Prevalence and Correlates of Cost-Related Medication Nonadherence to Immunosuppressive Drugs After Heart Transplantation: The International Multicenter Cross-sectional Bright Study

Author

Schonfeld, S., Denhaerynck, K., Berben, L., Dobbels, F., Russell, C. L., Crespo-Leiro, M. G., De Geest, S., Collaborations, Livi, U., and All, Et

Subjects
Adult, Male, Adolescent, medicine.medical_treatment, MEDLINE, Ethnic group, 030204 cardiovascular system & hematology, Heart transplantation, Logistic regression, heart transplantation, Drug Costs, Health Services Accessibility, Medication Adherence, healthcare costs, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Risk Factors, Health care, Odds Ratio, Prevalence, Health belief model, Medicine, Humans, 030212 general & internal medicine, Medication adherence, Aged, Advanced and Specialized Nursing, Aged, 80 and over, Heart Failure, business.industry, Odds ratio, Middle Aged, Healthcare costs, multilevel correlates, Confidence interval, Multilevel correlates, Cross-Sectional Studies, Logistic Models, ARTICLES: Heart Failure, Female, Self Report, Cardiology and Cardiovascular Medicine, business, Immunosuppressive Agents, Demography
Abstract

BACKGROUND: Cost-related medication nonadherence (CRMNA) refers to not taking medications as prescribed because of difficulties paying for them. OBJECTIVES: The aims of this study were (1) to assess the prevalence of CRMNA to immunosuppressants in heart transplant recipients internationally and (2) to determine multilevel correlates (patient, center, and healthcare system levels) of CRMNA. METHODS: Using data from the cross-sectional international BRIGHT study, applying multistaged sampling, CRMNA was assessed via 3 self-report items in 1365 patients from 36 heart transplant centers in 11 countries. Cost-related medication nonadherence was defined as any positive answer on any of the 3 items. Healthcare system-level (ie, insurance coverage, out-of-pocket expenditures) and patient-level (ie, intention, perceived financial burden, cost as a barrier, a health belief regarding medication benefits, cost-related self-efficacy, and demographic factors) CRMNA correlates were assessed. Correlates were examined using mixed logistic regression analysis. RESULTS: Across all study countries, CRMNA had an average prevalence of 2.6% (range, 0% [Switzerland/Brazil] to 9.8% [Australia]) and was positively related to being single (odds ratio, 2.29; 95% confidence interval, 1.17-4.47), perceived financial burden (odds ratio, 2.15; 95% confidence interval, 1.55-2.99), and cost as a barrier (odds ratio, 2.60; 95% confidence interval, 1.66-4.07). Four protective factors were identified: white ethnicity (odds ratio, 0.37; 95% confidence interval, 0.19-0.74), intention to adhere (odds ratio, 0.44; 95% confidence interval, 0.31-0.63), self-efficacy (odds ratio, 0.54; 95% confidence interval, 0.43-0.67), and belief about medication benefit (odds ratio, 0.70; 95% confidence interval, 0.57-0.87). Regarding variability, 81.3% was explained at the patient level; 13.8%, at the center level; and 4.8%, at the country level. CONCLUSION: In heart transplant recipients, the CRMNA prevalence varies across countries but is lower than in other chronically ill populations. Identified patient-level correlates are novel (ie, intention to adhere, cost-related barriers, and cost-related self-efficacy) and indicate patient-perceived medication cost burden. ispartof: Journal Of Cardiovascular Nursing vol:35 issue:6 pages:519-529 ispartof: location:United States status: published

Published
2020

49. Coronary Artery Disease of the Donor Graft: Any Impact on Survival and Cardiac Allograft Vasculopathy after Heart Transplantation?

Author

Lechiancole, A., primary, Sponga, S., additional, Vendramin, I., additional, Ferrara, V., additional, Maiani, M., additional, Spagna, E., additional, Guzzi, G., additional, Nalli, C., additional, Meneguzzi, M., additional, Nora, C. Di, additional, Piani, D., additional, Benedetti, G., additional, Tursi, V., additional, Zanuttini, D., additional, and Livi, U., additional

Published
2020
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